Mark Jenkins

32Do the risks of Lynch syndrome-related cancers depend on the parent-of-origin of the mutation?

Shimelis Gemechu, Christine M van Vliet, Aung Ko Win, Jane C Figueiredo, Loic Le Marchand, Steven Gallinger, Polly A Newcomb, John L Hopper, Noralane M Lindor, Mark A Jenkins, James G Dowty

Journal article  |  2021  |  International Journal of Epidemiology

Abstract Background Individuals who carry pathogenic mutations in DNA mismatch..

Informed choice and attitudes regarding a genomic test to predict risk of colorectal cancer in general practice.

Sibel Saya, Jennifer G McIntosh, Ingrid M Winship, Shakira Milton, Mark Clendenning, Mary Kyriakides, Jasmeen Oberoi, Daniel D Buchanan, Mark A Jenkins, Jon D Emery

Journal article  |  2021  |  Patient Educ Couns

OBJECTIVE: A genomic test to predict personal risk of colorectal cancer (CRC) that targets screening and could be feasibly impleme..

Association Between Smoking and Molecular Subtypes of Colorectal Cancer.

Xiaoliang Wang, Efrat Amitay, Tabitha A Harrison, Barbara L Banbury, Sonja I Berndt, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Yin Cao, Andrew T Chan, Jenny Chang-Claude, Steven J Gallinger, Marios Giannakis, Graham G Giles, Marc J Gunter, John L Hopper, Mark A Jenkins, Yi Lin, Victor Moreno, Reiko Nishihara, et al.

Journal article  |  2021  |  JNCI Cancer Spectr

Background: Smoking is associated with colorectal cancer (CRC) risk. Previous studies suggested this association may be restricted..

Tetranucleotide and Low Microsatellite Instability Are Inversely Associated with the CpG Island Methylator Phenotype in Colorectal Cancer

Sabine Meessen, Nicola Currey, Zeenat Jahan, Hannah W Parker, Mark A Jenkins, Daniel D Buchanan, John L Hopper, Eva Segelov, Jane E Dahlstrom, Maija RJ Kohonen-Corish

Journal article  |  2021  |  CANCERS

MSH3 gene or protein deficiency or loss-of-function in colorectal cancer can cause a DNA mismatch repair defect known as "elevated..

Abstract 816: Genetic variants associated with C-reactive protein and colorectal cancer survival: Sex- and lifestyle factors- specific associations

Yuhan Huang, Xinwei Hua, Julia D Labadie, Tabitha A Harrison, James Dai, Sara Lindstrom, Yi Lin, Sonja I Berndt, Daniel D Buchanan, Peter T Campbell, Graham Casey, Steven J Gallinger, Marc J Gunter, Michael Hoffmeister, Mark A Jenkins, Lori C Sakoda, Robert E Schoen, Brenda Diergaarde, Martha L Slattery, Emily White, et al.

Conference Proceedings  |  2021  |  Epidemiology

Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study

Mark A Jenkins

Journal article  |  2021  |  LANCET ONCOLOGY

BACKGROUND: Existing clinical practice guidelines for carriers of pathogenic variants of DNA mismatch repair genes (Lynch syndrome..

Genetically Predicted Circulating C-Reactive Protein Concentration and Colorectal Cancer Survival: A Mendelian Randomization Consortium Study

Xinwei Hua, James Y Dai, Sara Lindstrom, Tabitha A Harrison, Yi Lin, Steven R Alberts, Elizabeth Alwers, Sonja Berndt, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Graham Casey, Jenny Chang-Claude, Steven Gallinger, Graham G Giles, Richard M Goldberg, Marc J Gunter, Michael Hoffmeister, Mark A Jenkins, Amit D Joshi, et al.

Journal article  |  2021  |  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

BACKGROUND: A positive association between circulating C-reactive protein (CRP) and colorectal cancer survival was reported in obs..

Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer

Alexi N Archambault, Yi Lin, Jihyoun Jeon, Tabitha A Harrison, D Timothy Bishop, Hermann Brenner, Graham Casey, Andrew T Chan, Jenny Chang-Claude, Jane C Figueiredo, Steven Gallinger, Stephen B Gruber, Marc J Gunter, Michael Hoffmeister, Mark A Jenkins, Temitope O Keku, Loic Le Marchand, Li Li, Victor Moreno, Polly A Newcomb, et al.

Journal article  |  2021  |  JNCI CANCER SPECTRUM

Background: Incidence of early-onset (younger than 50 years of age) colorectal cancer (CRC) is increasing in many countries. Thus,..

Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study.

Konstantinos K Tsilidis, Nikos Papadimitriou, Niki Dimou, Dipender Gill, Sarah J Lewis, Richard M Martin, Neil Murphy, Georgios Markozannes, Verena Zuber, Amanda J Cross, Kimberley Burrows, David S Lopez, Timothy J Key, Ruth C Travis, Aurora Perez-Cornago, David J Hunter, Fränzel JB van Duijnhoven, Demetrius Albanes, Volker Arndt, Sonja I Berndt, et al.

Journal article  |  2021  |  American Journal of Clinical Nutrition

BACKGROUND: The literature on associations of circulating concentrations of minerals and vitamins with risk of colorectal cancer i..

Uptake of hysterectomy and bilateral salpingooophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

Toni T Seppala, Mev Dominguez-Valentin, Emma J Crosbie, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capella, Huw Thomas, Eivind Hovig, Maartje Nielsen, Rolf H Sijmons, Lucio Bertario, Bernardo Bonanni, Maria G Tibiletti, Giulia M Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann, et al.

Journal article  |  2021  |  EUROPEAN JOURNAL OF CANCER

PURPOSE: This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecologi..