Mark Jenkins

Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects.

Xingyi Guo, Weiqiang Lin, Wanqing Wen, Jeroen Huyghe, Stephanie Bien, Qiuyin Cai, Tabitha Harrison, Zhishan Chen, Conghui Qu, Jiandong Bao, Jirong Long, Yuan Yuan, Fangqin Wang, Mengqiu Bai, Goncalo R Abecasis, Demetrius Albanes, Sonja I Berndt, Stéphane Bézieau, D Timothy Bishop, Hermann Brenner, et al.

Journal article  |  2020  |  Gastroenterology

BACKGROUND AND AIMS: Susceptibility genes and the underlying mechanisms for the majority of risk loci identified by genome-wide as..

The Impact of a Comprehensive Risk Prediction Model for Colorectal Cancer on a Population Screening Program.

Sibel Saya, Jon D Emery, James G Dowty, Jennifer G McIntosh, Ingrid M Winship, Mark A Jenkins

Journal article  |  2020  |  JNCI Cancer Spectrum

Background: In many countries, population colorectal cancer (CRC) screening is based on age and family history, though more precis..

A Genomic Test for Colorectal Cancer Risk: Is This Acceptable and Feasible in Primary Care?

Sibel Saya, Jennifer G McIntosh, Ingrid M Winship, Mark Clendenning, Shakira Milton, Jasmeen Oberoi, James G Dowty, Daniel D Buchanan, Mark A Jenkins, Jon D Emery

Journal article  |  2020  |  Public Health Genomics

INTRODUCTION: Genomic tests can predict risk and tailor screening recommendations for colorectal cancer (CRC). Primary care could ..

Exploratory Genome-Wide Interaction Analysis of Nonsteroidal Anti-inflammatory Drugs and Predicted Gene Expression on Colorectal Cancer Risk

Xiaoliang Wang, Yu-Ru Su, Paneen S Petersen, Stephanie Bien, Stephanie L Schmit, David A Drew, Demetrius Albanes, Sonja Berndt, Hermann Brenner, Peter T Campbell, Graham Casey, Jenny Cheng-Claude, Steven Gallinger, Stephen B Gruber, Robert W Haile, Tabitha A Harrison, Michael Hoffmeister, Eric J Jacobs, Mark A Jenkins, Amit D Joshi, et al.

Journal article  |  2020  |  Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: Regular use of nonsteroidal anti-inflammatory drugs (NSAID) is associated with lower risk of colorectal cancer. Genome..

Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.

Mev Dominguez-Valentin, Julian R Sampson, Toni T Seppälä, Sanne W Ten Broeke, John-Paul Plazzer, Sigve Nakken, Christoph Engel, Stefan Aretz, Mark A Jenkins, Lone Sunde, Inge Bernstein, Gabriel Capella, Francesc Balaguer, Huw Thomas, D Gareth Evans, John Burn, Marc Greenblatt, Eivind Hovig, Wouter H de Vos Tot Nederveen Cappel, Rolf H Sijmons, et al.

Artefact  |  2020  |  Genetics in Medicine

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Postmenopausal Hormone Therapy and Colorectal Cancer Risk by Molecularly Defined Subtypes and Tumor Location.

Julia D Labadie, Tabitha A Harrison, Barbara Banbury, Efrat L Amtay, Sonja Bernd, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Yin Cao, Andrew T Chan, Jenny Chang-Claude, Dallas English, Jane C Figueiredo, Steven J Gallinger, Graham G Giles, Marc J Gunter, Michael Hoffmeister, Li Hsu, Mark A Jenkins, Yi Lin, et al.

Journal article  |  2020  |  JNCI Cancer Spectrum

Background: Postmenopausal hormone therapy (HT) is associated with a decreased colorectal cancer (CRC) risk. As CRC is a heterogen..

A general framework for functionally informed set-based analysis: Application to a large-scale colorectal cancer study

Xinyuan Dong, Yu-Ru Su, Richard Barfield, Stephanie A Bien, Qianchuan He, Tabitha A Harrison, Jeroen R Huyghe, Temitope O Keku, Noralane M Lindor, Clemens Schafmayer, Andrew T Chan, Stephen B Gruber, Mark A Jenkins, Charles Kooperberg, Ulrike Peters, Li Hsu

Journal article  |  2020  |  PLoS Genetics

Genome-wide association studies (GWAS) have successfully identified tens of thousands of genetic variants associated with various ..

Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival

Syed H Zaidi, Tabitha A Harrison, Amanda Phipps, Robert Steinfelder, Quang M Trinh, Conghui Qu, Barbara L Banbury, Peter Georgeson, Catherine S Grasso, Marios Giannakis, Jeremy B Adams, Elizabeth Alwers, Efrat L Amitay, Richard T Barfield, Sonja Berndt, Ivan Borozan, Hermann Brenner, Stefanie Brezina, Daniel D Buchanan, Yin Cao, et al.

Journal article  |  2020  |  Nature Communications

Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted seque..

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

Yan Dora Zhang, Amber N Hurson, Haoyu Zhang, Parichoy Pal Choudhury, Douglas F Easton, Roger L Milne, Jacques Simard, Per Hall, Kyriaki Michailidou, Joe Dennis, Marjanka K Schmidt, Jenny Chang-Claude, Puya Gharahkhani, David Whiteman, Peter T Campbell, Michael Hoffmeister, Mark Jenkins, Ulrike Peters, Li Hsu, Stephen B Gruber, et al.

Journal article  |  2020  |  Nature Communications

Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the i..

The Melanoma Genomics Managing Your Risk Study randomised controlled trial: statistical analysis plan.

Serigne N Lo, Amelia K Smit, David Espinoza, Anne E Cust, undefined Managing Your Risk Study Group

Journal article  |  2020  |  Trials

BACKGROUND: The Melanoma Genomics Managing Your Risk Study is a randomised controlled trial that aims to evaluate the efficacy of ..