Mark Jenkins

Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort.

Yu-Ru Su, Lori C Sakoda, Jihyoun Jeon, Minta Thomas, Yi Lin, Jennifer L Schneider, Natalia Udaltsova, Jeffrey K Lee, Iris Lansdorp-Vogelaar, Elisabeth FP Peterse, Ann G Zauber, Jiayin Zheng, Yingye Zheng, Elizabeth Hauser, John A Baron, Elizabeth L Barry, D Timothy Bishop, Hermann Brenner, Daniel D Buchanan, Andrea Burnett-Hartman, et al.

Journal article  |  2023  |  Cancer Epidemiol Biomarkers Prev

BACKGROUND: Polygenic risk scores (PRS) which summarize individuals' genetic risk profile may enhance targeted colorectal cancer s..

Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response.

Robert Carreras-Torres, Andre E Kim, Yi Lin, Virginia Díez-Obrero, Stephanie A Bien, Conghui Qu, Jun Wang, Niki Dimou, Elom K Aglago, Demetrius Albanes, Volker Arndt, James W Baurley, Sonja I Berndt, Stéphane Bézieau, D Timothy Bishop, Emmanouil Bouras, Hermann Brenner, Arif Budiarto, Peter T Campbell, Graham Casey, et al.

Journal article  |  2023  |  Cancer Epidemiol Biomarkers Prev

BACKGROUND: Tobacco smoking is an established risk factor for colorectal cancer. However, genetically defined population subgroups..

Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases.

Tomotaka Ugai, Naohiko Akimoto, Koichiro Haruki, Tabitha A Harrison, Yin Cao, Conghui Qu, Andrew T Chan, Peter T Campbell, Sonja I Berndt, Daniel D Buchanan, Amanda J Cross, Brenda Diergaarde, Steven J Gallinger, Marc J Gunter, Sophia Harlid, Akihisa Hidaka, Michael Hoffmeister, Hermann Brenner, Jenny Chang-Claude, Li Hsu, et al.

Journal article  |  2023  |  J Gastroenterol

BACKGROUND: The pathogenic effect of colorectal tumor molecular features may be influenced by several factors, including those rel..

Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.

Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Schmit, Virginia Díez-Obrero, Li Hsu, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Briggs, Victoria Svinti, Kevin Donnelly, Susan Farrington, James Blackmur, Peter Vaughan-Shaw, Xiao-Ou Shu, Jirong Long, Qiuyin Cai, et al.

Journal article  |  2023  |  Nat Genet

In the version of this article initially published, the author affiliations incorrectly listed “Candiolo Cancer Institute FPO-IRCC..

Body mass index and molecular subtypes of colorectal cancer.

Neil Murphy, Christina C Newton, Mingyang Song, Nikos Papadimitriou, Michael Hoffmeister, Amanda I Phipps, Tabitha A Harrison, Polly A Newcomb, Elom K Aglago, Sonja I Berndt, Hermann Brenner, Daniel D Buchanan, Yin Cao, Andrew T Chan, Xuechen Chen, Iona Cheng, Jenny Chang-Claude, Niki Dimou, David Drew, Alton B Farris, et al.

Journal article  |  2023  |  J Natl Cancer Inst

BACKGROUND: Obesity is an established risk factor for colorectal cancer (CRC), but the evidence for the association is inconsisten..

Evaluating Multiple Next-Generation Sequencing-Derived Tumor Features to Accurately Predict DNA Mismatch Repair Status.

Romy Walker, Peter Georgeson, Khalid Mahmood, Jihoon E Joo, Enes Makalic, Mark Clendenning, Julia Como, Susan Preston, Sharelle Joseland, Bernard J Pope, Ryan A Hutchinson, Kais Kasem, Michael D Walsh, Finlay A Macrae, Aung K Win, John L Hopper, Dmitri Mouradov, Peter Gibbs, Oliver M Sieber, Dylan E O'Sullivan, et al.

Journal article  |  2023  |  J Mol Diagn

Identifying tumor DNA mismatch repair deficiency (dMMR) is important for precision medicine. Tumor features, individually and in c..

The CRISP Trial: RCT of a decision support tool for risk-stratified colorectal cancer screening

Jon Emery, Mark A Jenkins, Sibel Saya, Patty Chondros, Jasmeen Oberoi, Shakira Milton, Kitty Novy, Emily Habgood, Napin Karnchanachari, Marie Pirotta, Lyndal Trevena, Adrian Bickerstaffe, Richard de Abreu Lourenco, Crothers Anna, Driss Ait Ouakrim, Louisa Flander, James G Dowty, Fiona M Walter, Malcolm Clark, Sally Doncovio, et al.

Journal article  |  2023  |  British Journal of General Practice

Background: A risk-stratified approach to colorectal cancer (CRC) screening could result in more acceptable balance of benefits an..

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.

Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Schmit, Virginia Díez-Obrero, Li Hsu, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Briggs, Victoria Svinti, Kevin Donnelly, Susan Farrington, James Blackmur, Peter Vaughan-Shaw, Xiao-Ou Shu, Jirong Long, Qiuyin Cai, et al.

Journal article  |  2023  |  Nat Genet

Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 1..

Molecular Characteristics of Early-onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison to Later-onset Cases: Molecular Characteristics and Early-onset Colorectal Tumor Subsites.

Tomotaka Ugai, Koichiro Haruki, Tabitha A Harrison, Yin Cao, Conghui Qu, Andrew T Chan, Peter T Campbell, Naohiko Akimoto, Sonja Berndt, Hermann Brenner, Daniel D Buchanan, Jenny Chang-Claude, Kenji Fujiyoshi, Steven J Gallinger, Marc J Gunter, Akihisa Hidaka, Michael Hoffmeister, Li Hsu, Mark A Jenkins, Roger L Milne, et al.

Journal article  |  2022  |  Am J Gastroenterol

OBJECTIVES: Early-onset colorectal cancer diagnosed before age 50 has been increasing. Likely reflecting the pathogenic role of th..

Abstract A010: Molecular characteristics and prognosis of early-onset colorectal cancer according to detailed anatomical locations: Comparison to later-onset cases

Tomotaka Ugai, Yin Cao, Koichiro Haruki, Tabitha A Harrison, Daniel D Buchanan, Peter T Campbell, Andrew T Chan, Steven Gallinger, Marc J Gunter, Michael Hoffmeister, Mark A Jenkins, Roger L Milne, Polly A Newcomb, Rish K Pai, Andrew J Pellatt, Robert E Schoen, Bethany Van Guelpen, Michael O Woods, Amanda I Phipps, Ulrike Peters, et al.

Journal article  |  2022  |  Cancer Research

Abstract Background: Evidence suggests that, compared to later-onset colorectal cancer (CRC), early-onset CRC (diag..