Mark Jenkins

Germline and Tumor Sequencing as a Diagnostic Tool To Resolve Suspected Lynch Syndrome.

Bernard J Pope, Mark Clendenning, Christophe Rosty, Khalid Mahmood, Peter Georgeson, Jihoon E Joo, Romy Walker, Ryan A Hutchinson, Harindra Jayasekara, Sharelle Joseland, Julia Como, Susan Preston, Amanda B Spurdle, Finlay A Macrae, Aung K Win, John L Hopper, Mark A Jenkins, Ingrid M Winship, Daniel D Buchanan

Journal article  |  2021  |  Journal of Molecular Diagnostics

Patients in whom mismatch repair (MMR)-deficient cancer develops in the absence of pathogenic variants of germline MMR genes or so..

Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects.

Xingyi Guo, Weiqiang Lin, Wanqing Wen, Jeroen Huyghe, Stephanie Bien, Qiuyin Cai, Tabitha Harrison, Zhishan Chen, Conghui Qu, Jiandong Bao, Jirong Long, Yuan Yuan, Fangqin Wang, Mengqiu Bai, Goncalo R Abecasis, Demetrius Albanes, Sonja I Berndt, Stéphane Bézieau, D Timothy Bishop, Hermann Brenner, et al.

Journal article  |  2021  |  Gastroenterology

BACKGROUND AND AIMS: Susceptibility genes and the underlying mechanisms for the majority of risk loci identified by genome-wide as..

An inverse stage-shift model to estimate the excess mortality and health economic impact of delayed access to cancer services due to the COVID-19 pandemic

Koen Degeling, Nancy N Baxter, Jon Emery, Mark A Jenkins, Fanny Franchini, Peter Gibbs, G Bruce Mann, Grant McArthur, Benjamin J Solomon, Maarten J IJzerman

Journal article  |  2021  |  Asia-Pacific Journal of Clinical Oncology

AIM: Decreased cancer incidence and reported changes to clinical management indicate that the COVID-19 pandemic has delayed cancer..

Association of Body Mass Index With Colorectal Cancer Risk by Genome-Wide Variants

Peter T Campbell, Yi Lin, Stephanie A Bien, Jane C Figueiredo, Tabitha A Harrison, Mark A Guinter, Sonja Berndt, Hermann Brenner, Andrew T Chan, Jenny Chang-Claude, Steven J Gallinger, Susan M Gapstur, Graham G Giles, Edward Giovannucci, Stephen B Gruber, Marc Gunter, Michael Hoffmeister, Eric J Jacobs, Mark A Jenkins, Loic Le Marchand, et al.

Journal article  |  2021  |  Journal of the National Cancer Institute

BACKGROUND: Body mass index (BMI) is a complex phenotype that may interact with genetic variants to influence colorectal cancer ri..

Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

Mev Dominguez-Valentin, Emma J Crosbie, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capella, Huw Thomas, Sigve Nakken, Eivind Hovig, Maartje Nielsen, Rolf H Sijmons, Lucio Bertario, Bernardo Bonanni, Maria Grazia Tibiletti, Giulia Martina Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann, et al.

Journal article  |  2020  |  Genetics in Medicine

PURPOSE: To determine impact of risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) on gynecological cancer incid..

Monoallelic NTHL1 Loss-of-Function Variants and Risk of Polyposis and Colorectal Cancer

Fadwa A Elsayed, Judith E Grolleman, Abiramy Ragunathan, Daniel D Buchanan, Tom van Wezel, Richarda M de Voer

Journal article  |  2020  |  Gastroenterology

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Iris Kramer, Maartje J Hooning, Nasim Mavaddat, Michael Hauptmann, Renske Keeman, Ewout W Steyerberg, Daniele Giardiello, Antonis C Antoniou, Paul DP Pharoah, Sander Canisius, Zumuruda Abu-Ful, Irene L Andrulis, Hoda Anton-Culver, Kristan J Aronson, Annelie Augustinsson, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, et al.

Journal article  |  2020  |  American Journal of Human Genetics

Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing ..

Postmenopausal Hormone Therapy and Colorectal Cancer Risk by Molecularly Defined Subtypes and Tumor Location

Julia D Labadie, Tabitha A Harrison, Barbara Banbury, Efrat L Amtay, Sonja Bernd, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Yin Cao, Andrew T Chan, Jenny Chang-Claude, Dallas English, Jane C Figueiredo, Steven J Gallinger, Graham G Giles, Marc J Gunter, Michael Hoffmeister, Li Hsu, Mark A Jenkins, Yi Lin, et al.

Journal article  |  2020  |  JNCI Cancer Spectrum

Background: Postmenopausal hormone therapy (HT) is associated with a decreased colorectal cancer (CRC) risk. As CRC is a heterogen..

The Impact of a Comprehensive Risk Prediction Model for Colorectal Cancer on a Population Screening Program

Sibel Saya, Jon D Emery, James G Dowty, Jennifer G McIntosh, Ingrid M Winship, Mark A Jenkins

Journal article  |  2020  |  JNCI Cancer Spectrum

Background: In many countries, population colorectal cancer (CRC) screening is based on age and family history, though more precis..

A Genomic Test for Colorectal Cancer Risk: Is This Acceptable and Feasible in Primary Care?

Sibel Saya, Jennifer G McIntosh, Ingrid M Winship, Mark Clendenning, Shakira Milton, Jasmeen Oberoi, James G Dowty, Daniel D Buchanan, Mark A Jenkins, Jon D Emery

Journal article  |  2020  |  Public Health Genomics

INTRODUCTION: Genomic tests can predict risk and tailor screening recommendations for colorectal cancer (CRC). Primary care could ..