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Prof

Ashley Bush

Professor
Florey Department Of Neuroscience And Mental Health
therapeutics
iron
oxidative stress
metals
Copper
diagnostics
science & technology
life sciences & biomedicine
humans
Ashley Bush's Profile Picture
Prof

Ashley Bush

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Motor Neurone Disease
Ashley Bush's Profile Picture
Prof

Ashley Bush

 

Ashley Bush (MBBS, DPM, FRANZCP, PhD, FAAHMS, FAPA), NHMRC Senior Principal Research Fellow is the Director of the Melbourne Dementia Research Centre and Head of the Oxidation Biology Unit at The Florey Institute of Neuroscience & Mental Health, University of Melbourne. He has made outstanding contributions to the neuroscience field, most notably his discovery of the importance of metals and oxidative stress in neurological disease.

The impact of his work has moved the field of neurodegeneration towards an appreciation for an underlying disturbance in brain metal homeostasis, and has provided insights into the pathogenesis of Alzheimer’s disease (AD) as well as other brain diseases including amyotrophic lateral sclerosis, Parkinson’s and Huntington’s diseases. His leadership has led to the development of new predictive tests for AD and innovative, potentially disease-modifying strategies based on his research. He is Chief Scientific Officer for the Cooperative Research Centre for Mental Health (Parkville) and Co-Director of Biomarker Development for The Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL). He is Professor of Neuroscience and Psychiatry at the University of Melbourne, and holds courtesy staff appointments in Psychiatry and Radiology at Massachusetts General Hospital, USA. He is Founding Scientist of Prana Biotechnology Ltd, Cogstate Ltd, and Chief Scientific Officer for Collaborative Medicinal Development P/L. As a recognised expert in his field, Prof Bush has published 455+ publications (>43,600 citations) and 28 patents, is ad hoc reviewer of 52 journals, and has delivered over 320 invited lectures (including 211 international and 26 Plenary). Prof Bush is one of the most highly cited neuroscientists in Australia, is rated in the top 1% of neuroscience researchers worldwide for high impact citations (2014-2016, 2018, 2019), and classed as one of the World's Most Influential Scientific Minds (Thomson Reuters & Clarivate Analytics).

Projects

Displaying the 33 most recent projects by Ashley Bush.

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Centre Of Research Excellence In Neuroimaging

2020 - 2025
Active
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Emerging Strategies To Relieve Proteotoxicity In Neurodegenerative Disorders: Focus On Insulin/Igf Signaling And The Metalloregulation Of Protein Degradation

2019 - 2019
Completed
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Molecular Study Of Copper-Promoted Ubiquitination

This project aims to study copper-promoted ubiquitination, a novel discovery that a conserved copper binding site in conjugating enzyme UBE2..

2019 - 2021
Active
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Iron, Ferroptosis And The Biology Of Ageing

This project aims to determine how and when regulation of iron is lost. Failing iron metabolism during life may dictate the rate of ageing b..

2018 - 2021
Active
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Drug-Specific Biomarkers To Facilitate Clinical Translation Of Cuii(Atsm) As A Potential Therapeutic For Mnd.

2016 - 2017
Completed
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Drug-Specific Biomarkers To Facilitate Clinical Translation Of Cuii(Atsm) As A Potential Therapeutic For Mnd.

2016 - 2017
Completed
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The Role Of Copper In The Early Ubiquitination Pathway

This project aims to explore the role of copper in ageing and protein turnover. The removal of damaged or excess proteins is achieved by ubi..

2016 - 2019
Completed
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Brain Iron Imaging For Alzheimer’S Disease (Aibl-Adiron Study)

Iron accumulation in the brain is linked to Alzheimer's disease. New Magnetic Resonance Imaging scans allow us to painlessly image the brain..

2016 - 2020
Active
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Zndtsm For Huntington'S Disease

Huntington’s disease is a devastating neurological disorder, with no drugs currently available to cure or treat the underlying cause. Our re..

2016 - 2016
Completed
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7t Healthy Ageing Study

2015 - 2017
Completed
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The Effects Of Zinc On The Stability Of Apoliprotein E (Apoe) Isoforms In Alzheimer'S Disease

2015 - 2015
Completed
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Iron Accumulation In C.Elegans: A Model Of Ageing

This project will investigate the role of biological metals in the process of ageing, the causes of which remain unresolved. The practical o..

2013 - 2016
Completed
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Platelet Tau As A Peripheral Blood Biomarker For Alzheimer'S Disease

2013 - 2014
Completed
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Iron Export Protein Failure In Parkinsonism And Dementia

We recently discovered a novel relationship between the Alzheimer’s amyloid precursor protein (APP) and tau, and that both proteins play a r..

2013 - 2016
Completed
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Diseases Of The Ageing Brain

The Neurodegeneration Program is discovering the basic pathways that cause Alzheimer’s disease and related diseases of the aging brain; from..

2012 - 2015
Completed
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Translational Therapeutics And Diagnostics For Alzheimer'S Disease

nan

2011 - 2015
Completed
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Diseases Of The Ageing Brain

The Neurodegeneration Program is discovering the basic pathways that cause Alzheimer’s disease and related diseases of the aging brain; from..

2011 - 2015
Completed
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Diseases Of The Ageing Brain

The Neurodegeneration Program is discovering the basic pathways that cause Alzheimer’s disease and related diseases of the aging brain; from..

2011 - 2015
Completed
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Diseases Of The Ageing Brain

The Neurodegeneration Program is discovering the basic pathways that cause Alzheimer’s disease and related diseases of the aging brain; from..

2011 - 2015
Completed
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Diseases Of The Ageing Brain

The Neurodegeneration Program is discovering the basic pathways that cause Alzheimer’s disease and related diseases of the aging brain; from..

2011 - 2015
Completed
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Diseases Of The Ageing Brain

The Neurodegeneration Program is discovering the basic pathways that cause Alzheimer’s disease and related diseases of the aging brain; from..

2011 - 2015
Completed
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Diseases Of The Ageing Brain

The Neurodegeneration Program is discovering the basic pathways that cause Alzheimer’s disease and related diseases of the aging brain; from..

2011 - 2015
Completed
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Neural Copper Homeostasis: The Role Of The Alzheimer Amyloid-Beta Precursor Protein

Alzheimer's disease (AD) is creating a growing burden upon Australian medical resources. Copper plays an important role in the development o..

2009 - 2011
Completed
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Amyloid Precursor Protein Aids Iron Efflux From Neurons

Our group has discovered a novel role of amyloid precursor protein (APP) in cellular iron balance. The smallest form of APP, prevalently fou..

2009 - 2012
Completed
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The Drug Aprotinin May Regulate Iron In Blood And Cardiovascular Tissue

2009 - 2010
Completed
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Application Of Copper-64 In Studies Of The Role Of Copper In Alzheimer'S Disease

2009 - 2009
Completed
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Investigating Protein/Protein Interactions

To establish and maintain a prominent position in scientific research, Australian scientists must have access to state of the art technology..

2008 - 2009
Completed
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Novel Therapies For Alzheimer'S Disease Based On A-Beta - Metal Interactions

The genetic data clearly show that the amyloid protein (A-beta) is central to the brain damage which occurs in Alzheimer's disease (AD). How..

2001 - 2005
Completed
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The Role Of Amyloid Protein Precursor In Mammalian Copper Transport

The knowledge gained from this investigation will help us to develop new medicines for the treatment of debilitating and ever more prevalent..

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Application Of Copper-64 To Studies On Alzheimer'S Disease And Characterisation Of Novel Genes And Proteins Involved In Copper Homeostasis

Completed
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Neurodegenerative Diseases Of The Aging Brain: Diagnosis & Therapy Based On The Study Of Aggreagated Protein Depositions

nan

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2 Vertical Freezers, -20; 365day Timeclock & Bypass Switch; Criterion Cell/Plate Blotter System, Cells, Tray

nan

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Neurodegenerative Diseases Of The Aging Brain: Diagnosis & Therapy Based On The Study Of Aggreagated Protein Depositions

nan

33

Projects

Project Types

29

Research Grant

3

Research Contracts

1

Internal Research Grant

Scholarly Works

Displaying the 554 most recent scholarly works by Ashley Bush.

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Cerebrospinal fluid ceruloplasmin levels predict cognitive decline and brain atrophy in people with underlying β-amyloid pathology.

Ibrahima Diouf, Ashley I Bush, Scott Ayton, undefined Alzheimer's disease Neuroimaging Initiative

Journal article  |  2020  |  Neurobiology of Disease

OBJECTIVES: The mechanisms leading to neurodegeneration in Alzheimer's disease (AD) may involve oxidative stress and neuroinflamma..

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Preferential Neurodegeneration in the Dentate Gyrus by Amyloid beta(1-42)-Induced Intracellular Zn(2 )Dysregulation and Its Defense Strategy

Haruna Tamano, Mako Takiguchi, Yukino Tanaka, Taku Murakami, Paul A Adlard, Ashley I Bush, Atsushi Takeda

Journal article  |  2020  |  Molecular Neurobiology

On the basis of the evidence that rapid intracellular Zn2+ dysregulation by amyloid β1-42 (Aβ1-42) in the normal hippocampus trans..

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Regional iron distribution and soluble ferroprotein profiles in the healthy human brain

Erin J McAllum, Dominic J Hare, Irene Volitakis, Catriona A McLean, Ashley I Bush, David I Finkelstein, Blaine R Roberts

Journal article  |  2020  |  Progress in Neurobiology

Iron is essential for brain development and health where its redox properties are used for a number of neurological processes. How..

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Iron chelation by deferiprone does not rescue the Niemann-Pick Disease Type C1 mouse model

Ya Hui Hung, Amit Lotan, Shlomo Yeshurun, Anna Schroeder, Ashley I Bush

Journal article  |  2020  |  BioMetals

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The ubiquitin proteasome system and schizophrenia.

Sandra Luza, Carlos M Opazo, Chad A Bousman, Christos Pantelis, Ashley I Bush, Ian P Everall

Journal article  |  2020  |  The Lancet Psychiatry

The ubiquitin-proteasome system is a master regulator of neural development and the maintenance of brain structure and function. I..

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Zinc Transporter-3 Knockout Mice Demonstrate Age-Dependent Alterations in the Metalloproteome

Sara M Hancock, Stuart D Portbury, Adam P Gunn, Blaine R Roberts, Ashley I Bush, Paul A Adlard

Journal article  |  2020  |  International Journal of Molecular Sciences

Metals are critical cellular elements that are involved in a variety of cellular processes, with recent literature demonstrating t..

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Cu-II(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease

Adam Southon, Kathryn Szostak, Karla M Acevedo, Krista A Dent, Irene Volitakis, Abdel A Belaidi, Kevin J Barnham, Peter J Crouch, Scott Ayton, Paul S Donnelly, Ashley Bush

Journal article  |  2020  |  British Journal of Pharmacology

BACKGROUND AND PURPOSE: Diacetyl-bis(4-methyl-3-thiosemicarbazonato)copperII (CuII (atsm)) ameliorates neurodegeneration and delay..

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Cerebrospinal fluid neurofilament light concentration predicts brain atrophy and cognition in Alzheimer's disease.

Kunal Dhiman, Veer Bala Gupta, Victor L Villemagne, Dhamidhu Eratne, Petra L Graham, Christopher Fowler, Pierrick Bourgeat, Qiao-Xin Li, Steven Collins, Ashley I Bush, Christopher C Rowe, Colin L Masters, David Ames, Eugene Hone, Kaj Blennow, Henrik Zetterberg, Ralph N Martins

Journal article  |  2020  |  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

Introduction: This study assessed the utility of cerebrospinal fluid (CSF) neurofilament light (NfL) in Alzheimer's disease (AD) d..

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Brain Zinc Deficiency Exacerbates Cognitive Decline in the R6/1 Model of Huntington's Disease.

Scott Ayton, Peng Lei, Ambili T Appukuttan, Thibault Renoir, Simote Foliaki, Feng Chen, Paul A Adlard, Anthony J Hannan, Ashley I Bush

Journal article  |  2020  |  Neurotherapeutics

There is currently no disease-modifying treatment for Huntington's disease (HD), which is characterized by chorea motor impairment..

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Axonal dispatch of iron in neuronal signaling

Peng Lei, Scott Ayton, Ashley I Bush

Journal article  |  2019  |  Nature Chemical Biology

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Late Life Iron Accumulation, Cell Death and Frailty

Nicole Jenkins, Simon James, Ashley Bush, Gawain McColl

Conference Proceedings  |  2019  |  Free Radical Biology and Medicine

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Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity (vol 56, pg 5471, 2019)

Kathryn Cimdins, Hayley S Waugh, Vicki Chrysostomou, M Isabel G Lopez Sanchez, Vanessa A Johanssen, Mark J Cook, Jonathan G Crowston, Andrew F Hill, James A Duce, Ashley I Bush, Ian A Trounce

Journal article  |  2019  |  Molecular Neurobiology

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Treating Alzheimer's disease by targeting iron

Sara Nikseresht, Ashley Bush, Scott Ayton

Journal article  |  2019  |  British Journal of Pharmacology

No disease modifying drugs have been approved for Alzheimer's disease despite recent major investments by industry and governments..

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Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity

Kathryn Cimdins, Hayley S Waugh, Vicki Chrysostomou, M Isabel G Lopez Sanchez, Vanessa A Johannsen, Mark J Cook, Jonathan G Crowston, Andrew F Hill, James A Duce, Ashley I Bush, Ian A Trounce

Journal article  |  2019  |  Molecular Neurobiology

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Decreasing iron neurotoxicity in pantothenate kinase-associated neurodegeneration

Scott Ayton, Ashley I Bush

Journal article  |  2019  |  The Lancet Neurology

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The Effects of Clioquinol on P-glycoprotein Expression and Biometal Distribution in the Mouse Brain Microvasculature

Mitchell P McInerney, Yijun Pan, Irene Volitakis, Ashley I Bush, Jennifer L Short, Joseph A Nicolazzo

Journal article  |  2019  |  Journal of Pharmaceutical Sciences

Previous studies have demonstrated that the ionophore clioquinol (CQ), in conjunction with the biometals copper and zinc, increase..

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L-3,4-dihydroxyphenylalanine (L-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease

Jessica L Billings, Sarah L Gordon, Tristan Rawling, Philip A Doble, Ashley I Bush, Paul A Adlard, David I Finkelstein, Dominic J Hare

Journal article  |  2019  |  Journal of Neurochemistry

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Amyloid beta(1-42)-Induced Rapid Zn2 Influx into Dentate Granule Cells Attenuates Maintained LTP Followed by Retrograde Amnesia

Haruna Tamano, Hiroki Suzuki, Taku Murakami, Hiroaki Fujii, Paul A Adlard, Ashley I Bush, Atsushi Takeda

Journal article  |  2019  |  Molecular Neurobiology

On the basis of the evidence that amyloid β1-42 (Aβ1-42)-induced Zn2+ influx affects memory acquisition via attenuated long-term p..

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Extracellular Zn2 -independently attenuated LTP by human amyloid beta(1-40) and rat amyloid beta(1-42)

Haruna Tamano, Mako Takiguchi, Ryota Shimaya, Paul A Adlard, Ashley I Bush, Atsushi Takeda

Journal article  |  2019  |  Biochemical and Biophysical Research Communications

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Cellular Senescence and Iron Dyshomeostasis in Alzheimer's Disease

Shashank Masaldan, Abdel Ali Belaidi, Scott Ayton, Ashley Bush

Journal article  |  2019  |  Pharmaceuticals

Iron dyshomeostasis is a feature of Alzheimer's disease (AD). The impact of iron on AD is attributed to its interactions with the ..

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Redox Modulating Factors Affect Longevity Regulation in Rotifers

Lilla Macsai, Zita Olah, Ashley I Bush, Bence Galik, Rita Onody, Janos Kalman, Zsolt Datki

Journal article  |  2019  |  The Journals of Gerontology: Series A

Rotifers are microinvertebrate models to study the phylogenetically based mechanisms of aging. Our study aimed to develop a physio..

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Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia

Hannah Meiklejohn, Md Shaki Mostaid, Sandra Luza, Serafino G Mancuso, Dali Kang, Sonny Atherton, Debora A Rothmond, Cynthia Shannon Weickert, Carlos M Opazo, Christos Pantelis, Ashley I Bush, Ian P Everall, Chad A Bousman

Journal article  |  2019  |  Journal of Psychiatric Research

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Difference in ability for extracellular Zn2 influx between human and rat amyloid beta(1-42) and its significance

Haruna Tamano, Hiroki Suzuki, Shuhei Kobuchi, Paul A Adlard, Ashley I Bush, Atsushi Takeda

Journal article  |  2019  |  NeuroToxicology

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Mice overexpressing hepcidin suggest ferroportin does not play a major role in Mn homeostasis

Lian Jin, David M Frazer, Yan Lu, Sarah J Wilkins, Scott Ayton, Ashley Bush, Gregory J Anderson

Journal article  |  2019  |  Metallomics

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In vivo synaptic activity-independent co-uptakes of amyloid beta(1-42) and Zn2 into dentate granule cells in the normal brain

Haruna Tamano, Naoya Oneta, Aoi Shioya, Paul A Adlard, Ashley Bush, Atsushi Takeda

Journal article  |  2019  |  Scientific Reports

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Parkinson's disease prevalence and the association with rurality and agricultural determinants

Darshini Ayton, Scott Ayton, Anna L Barker, Ashley I Bush, Narelle Warren

Journal article  |  2019  |  Parkinsonism & Related Disorders

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Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying beta-amyloid pathology

Ibrahima Diouf, Amir Fazlollahi, Ashley I Bush, Scott Ayton

Journal article  |  2019  |  Neurobiology of Disease

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Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration

Shashank Masaldan, Ashley I Bush, David Devos, Anne Sophie Rolland, Caroline Moreau

Journal article  |  2019  |  Free Radical Biology and Medicine

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Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia

Chad A Bousman, Sandra Luza, Serafino G Mancuso, Dali Kang, Carlos M Opazo, Md Shaki Mostaid, Vanessa Cropley, Patrick McGorry, Cynthia Shannon Weickert, Christos Pantelis, Ashley I Bush, Ian P Everall

Journal article  |  2019  |  Scientific Reports

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Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology.

Scott Ayton, Yamin Wang, Ibrahima Diouf, Julie A Schneider, John Brockman, Martha Clare Morris, Ashley I Bush

Journal article  |  2019  |  Molecular Psychiatry

Cortical iron has been shown to be elevated in Alzheimer's disease (AD), but the impact of the directly measured iron on the clini..

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A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer's disease

Nicholas J Ashton, Alejo J Nevado-Holgado, Imelda S Barber, Steven Lynham, Veer Gupta, Pratishtha Chatterjee, Kathryn Goozee, Eugene Hone, Steve Pedrini, Kaj Blennow, Michael Scholl, Henrik Zetterber, Kathryn A Ellis, Ashley Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Dag Aarsland, John Powell, et al.

Journal article  |  2019  |  Science Advances

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Molecular Mechanisms of Glutaredoxin Enzymes: Versatile Hubs for Thiol-Disulfide Exchange between Protein Thiols and Glutathione

Zhiguang Xiao, Sharon La Fontaine, Ashley I Bush, Anthony G Wedd

Journal article  |  2019  |  Journal of Molecular Biology

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The Down Syndrome-Associated Protein, Regulator of Calcineurin-1, is Altered in Alzheimer's Disease and Dementia with Lewy Bodies

N Malakooti, C FOWLER, I Volitakis, CA McLean, RC Kim, Ashley Bush, A REMBACH, MA PRITCHARD, DI Finkelstein, PA Adlard

Journal article  |  2019  |  Journal of Alzheimer's disease & Parkinsonism

There is a known relationship between Alzheimer's disease (AD) and Down syndrome (DS), with the latter typically developing AD-lik..

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Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer's Disease

Barbara R Cardoso, Blaine R Roberts, Charles B Malpas, Lucy Vivash, Sila Genc, Michael M Saling, Patricia Desmond, Christopher Steward, Rodney J Hicks, Jason Callahan, Amy Brodtmann, Steven Collins, Stephen Macfarlane, Niall M Corcoran, Christopher M Hovens, Dennis Velakoulis, Terence J O'Brien, Dominic J Hare, Ashley I Bush

Journal article  |  2019  |  Neurotherapeutics

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Redox active metals in neurodegenerative diseases

Karla Acevedo, Shashank Masaldan, Carlos M Opazo, Ashley I Bush

Journal article  |  2019  |  JBIC Journal of Biological Inorganic Chemistry

Copper (Cu) and iron (Fe) are redox active metals essential for the regulation of cellular pathways that are fundamental for brain..

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Zn-DTSM, A Zinc Ionophore with Therapeutic Potential for Acrodermatitis Enteropathica?

Lisa Bray, Irene Volitakis, Scott Ayton, Ashley I Bush, Paul A Adlard

Journal article  |  2019  |  Nutrients

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UBIQUITINATED PROTEINS ARE ELEVATED IN THE BLOOD AND BRAIN OF INDIVIDUALS WITH SCHIZOPHRENIA

Chad Bousman, Sandra Luza, Serafino Mancuso, Dali Kang, Md Shaki Mostaid, Vanessa Cropley, Cynthia Shannon Weickert, Carlos Opazo, Christos Pantelis, Ashley Bush, Ian Paul Everall

Conference Proceedings  |  2019  |  European Neuropsychopharmacology

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Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression

Bruna Panizzutti, Chiara Bortolasci, Kyoko Hasebe, Srisaiyini Kidnapillai, Laura Gray, Ken Walder, Michael Berk, Mohammadreza Mohebbi, Seetal Dodd, Clarissa Gama, Pedro V Magalhaes, Susan M Cotton, Flavio Kapczinski, Ashley I Bush, Gin S Malhi, Olivia M Dean

Journal article  |  2018  |  Acta Neuropsychiatrica

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Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin

Vivek Venkataramani, Thorsten R Doeppner, Desiree Willkommen, Catherine M Cahill, Yongjuan Xin, Guilin Ye, Yanyan Liu, Adam Southon, Allegra Aron, Ho Yu Au-Yeung, Xudong Huang, Debomoy K Lahiri, Fudi Wang, Ashley I Bush, Gerald G Wulf, Philipp Stroebel, Bernhard Michalke, Jack T Rogers

Journal article  |  2018  |  Journal of Neurochemistry

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Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

Denzil Furtado, Mattias Bjornmalm, Scott Ayton, Ashley I Bush, Kristian Kempe, Frank Caruso

Journal article  |  2018  |  Advanced Materials

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Adrenergic beta receptor activation in the basolateral amygdala, which is intracellular Zn2 -dependent, rescues amyloid beta(1-42)-induced attenuation of dentate gyrus LTP

Haruna Tamano, Mitsuyasu Kubota, Yuki Fujise, Ryota Shimaya, Ryusei Itoh, Miki Suzuki, Paul A Adlard, Ashley Bush, Atsushi Takeda

Journal article  |  2018  |  Neurochemistry International

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Association of metals with the risk and clinical characteristics of Parkinson's disease

Mi-Jung Kim, Shin-Bi Oh, Juyeon Kim, Kiju Kim, Ho-Sung Ryu, Min Sun Kim, Scott Ayton, Ashley I Bush, Joo-Yong Lee, Sun Ju Chung

Journal article  |  2018  |  Parkinsonism & Related Disorders

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Novel Defense by Metallothionein Induction Against Cognitive Decline: From Amyloid beta(1-42)-Induced Excess Zn2 to Functional Zn2 Deficiency

Atsushi Takeda, Haruna Tamano, Wakana Hashimoto, Shuhei Kobuchi, Hiroki Suzuki, Taku Murakami, Munekazu Tempaku, Yuta Koike, Paul A Adlard, Ashley I Bush

Journal article  |  2018  |  Molecular Neurobiology

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Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

Abdel A Belaidi, Adam P Gunn, Bruce X Wong, Scott Ayton, Ambili T Appukuttan, Blaine R Roberts, James A Duce, Ashley I Bush

Journal article  |  2018  |  Neurotherapeutics

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Targeting metals rescues the phenotype in an animal model of tauopathy

Amelia Sedjahtera, Lydia Gunawan, Lisa Bray, Lin Wai Hung, Jack Parsons, Nobuyuki Okamura, Victor L Villemagne, Kazuhiko Yanai, Xiang M Liu, Jacky Chan, Ashley I Bush, David I Finkelstein, Kevin J Barnham, Robert A Cherny, Paul A Adlard

Journal article  |  2018  |  Metallomics

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Elevated plasma ferritin in elderly individuals with high neocortical amyloid-beta load

K Goozee, P Chatterjee, I James, K Shen, HR Sohrabi, PR Asih, P Dave, C ManYan, K Taddei, SJ Ayton, ML Garg, JB Kwok, A Bush, R Chung, JS Magnussen, RN Martins

Journal article  |  2018  |  Molecular Psychiatry

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Generation and characterization of human induced pluripotent stem cell lines from a familial Alzheimer's disease PSEN1 A246E patient and a non-demented family member bearing wild-type PSEN1

Sonia Sanz Munoz, Rachelle Balez, Mauricio E Castro Cabral-da-Silva, Tracey Berg, Martin Engel, Monique Bax, Dzung Do-Ha, Claire H Stevens, Mark Greenough, Ashley Bush, Lezanne Ooi

Journal article  |  2018  |  Stem Cell Research

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Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease

Leah C Beauchamp, Jacky Chan, Lin W Hung, Benjamin S Padman, Laura J Vella, Xiang M Liu, Bradley Coleman, Ashley I Bush, Michael Lazarou, Andrew F Hill, Laura Jacobson, Kevin J Barnham

Journal article  |  2018  |  Acta Neuropathologica Communications

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Iron and ferroptosis in the pathogenesis of Alzheimer's disease

Scott Ayton, Ashley I Bush

Conference Proceedings  |  2018  |  Free Radical Biology and Medicine

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Evidence that iron accelerates Alzheimer's pathology: a CSF biomarker study

Scott Ayton, Ibrahima Diouf, Ashley Ian Bush

Journal article  |  2018  |  Journal of Neurology, Neurosurgery & Psychiatry

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Ionophore and Biometal Modulation of P-glycoprotein Expression and Function in Human Brain Microvascular Endothelial Cells

Mitchell P McInerney, Irene Volitakis, Ashley I Bush, William A Banks, Jennifer L Short, Joseph A Nicolazzo

Journal article  |  2018  |  Pharmaceutical Research

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Iron as a therapeutic target for Parkinson's disease

Caroline Moreau, James A Duce, Olivier Rascol, Jean-Christophe Devedjian, Daniela Berg, David Dexter, Z Ioav Cabantchik, Ashley I Bush, David Devos

Journal article  |  2018  |  Movement Disorders

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Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

Shashank Masaldan, Sharnel AS Clatworthy, Cristina Gamell, Peter M Meggyesy, Antonia-Tonia Rigopoulos, Sue Haupt, Ygal Haupt, Delphine Denoyer, Paul A Adlard, Ashley I Bush, Michael A Cater

Journal article  |  2018  |  Redox Biology

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FACULTY OF CHILD AND ADOLESCENT PSYCHIATRY GLOBAL MENTAL HEALTH INITIATIVES: PARTNERSHIPS IN THE ASIA-PACIFIC REGION

P Robertson, A Bush, N Kowalenko, E Hunter

Conference Proceedings  |  2018  |  AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

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Cognitive gene risk profile for the prediction of cognitive decline in presymptomatic Alzheimer’s disease

Tenielle Porter, Victor L Villemagne, Greg Savage, Lidija Milicic, Yen Ying Lim, Paul Maruff, Colin L Masters, David Ames, Ashley I Bush, Ralph N Martins, Stephanie Rainey-Smith, Christopher C Rowe, Kevin Taddei, David Groth, Giuseppe Verdile, Samantha C Burnham, Simon M Laws

Journal article  |  2018  |  Personalized Medicine in Psychiatry

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Glutaredoxins employ parallel monothiol-dithiol mechanisms to catalyze thiol-disulfide exchanges with protein disulfides

Ashwinie A Ukuwela, Ashley I Bush, Anthony G Wedd, Zhiguang Xiao

Journal article  |  2018  |  Chemical Science

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KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE epsilon 4-positive cognitively normal adults with high A beta-amyloid burden

Tenielle Porter, Samantha C Burnham, Vincent Dore, Greg Savage, Pierrick Bourgeat, Kimberly Begemann, Lidija Milicic, David Ames, Ashley I Bush, Paul Maruff, Colin L Masters, Christopher C Rowe, Stephanie Rainey-Smith, Ralph N Martins, David Groth, Giuseppe Verdile, Victor L Villemagne, Simon M Laws

Journal article  |  2018  |  Scientific Reports

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What can predict and prevent the long-term use of benzodiazepines?

Takeo Hata, Tetsufumi Kanazawa, Takeshi Hamada, Masami Nishihara, Ashley Ian Bush, Hiroshi Yoned, Miki Nakajima, Takahiro Katsumata

Journal article  |  2018  |  Journal of Psychiatric Research

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A Framework to Objectively Identify Reference Regions for Normalizing Quantitative Imaging

Amir Fazlollahi, Scott Ayton, Pierrick Bourgeat, Ibrahima Diouf, Parnesh Raniga, Jurgen Fripp, James Doecke, David Ames, Colin L Masters, Christopher C Rowe, Victor L Villemagne, Ashley I Bush, Olivier Salvado

Conference Proceedings  |  2018  |  Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

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Alzheimer's Disease: A Journey (f)rom Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies

Ralph N Martins, Victor Villemagnen, Hamid R Sohrabi, Pratishtha Chatterjee, Tejal M Shah, Giuseppe Verdile, Paul Fraser, Kevin Taddei, Veer B Gupta, Stephanie R Rainey-Smith, Eugene Hone, Steve Pedrini, Wei Ling Lim, Ian Martins, Shaun Frost, Sunil Gupta, Sid O'Bryant, Alan Rembach, David Ames, Kathryn Ellis, et al.

Journal article  |  2018  |  Journal of Alzheimer's Disease

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Iron and Alzheimer's Disease: An Update on Emerging Mechanisms

Darius JR Lane, Scott Ayton, Ashley I Bush

Journal article  |  2018  |  Journal of Alzheimer's Disease

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Concordance Between Cerebrospinal Fluid Biomarkers with Alzheimer's Disease Pathology Between Three Independent Assay Platforms

James D Doecke, Alan Rembach, Victor L Villemagne, Shiji Varghese, Stephanie Rainey-Smith, Shannon Sarros, Lisbeth A Evered, Christopher J Fowler, Kelly K Pertile, Rebecca L Rumble, Brett Trounson, Kevin Taddei, Simon M Laws, S Lance Macaulay, Ashley I Bush, Kathryn A Ellis, Ralph Martins, David Ames, Brendan Silbert, Hugo Vanderstichele, et al.

Journal article  |  2018  |  Journal of Alzheimer's Disease

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Metals and Alzheimer's Disease: How Far Have We Come in the Clinic?

Paul A Adlard, Ashley I Bush

Journal article  |  2018  |  Journal of Alzheimer's Disease

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Iron and Alzheimer's Disease: An Update on Emerging Mechanisms

Darius JR Lane, Scott Ayton, Ashley I Bush

Book Chapter  |  2018  |  Advances in Alzheimer's Disease

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S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency

Avadh Kumar, Borislav Dejanovic, Florian Hetsch, Marcus Semtner, Debora Fusca, Sita Arjune, Jose Angel Santamaria-Araujo, Aline Winkelmann, Scott Ayton, Ashley I Bush, Peter Kloppenburg, Jochen C Meier, Guenter Schwarz, Abdel Ali Belaidi

Journal article  |  2017  |  Journal of Clinical Investigation

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Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymes

Ashwinie A Ukuwela, Ashley I Bush, Anthony G Wedd, Zhiguang Xiao

Journal article  |  2017  |  Biochemical Journal

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Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

Q-Z Tuo, P Lei, KA Jackman, X-I Li, H Xiong, X-L Li, Z-Y Liuyang, L Roisman, S-T Zhang, S Ayton, Q Wang, PJ Crouch, K Ganio, X-C Wang, L Pei, PA Adlard, Y-M Lu, R Cappai, J-Z Wang, R Liu, et al.

Journal article  |  2017  |  Molecular Psychiatry

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A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of beta-amyloid load in an AD cohort

Steve Pedrini, Veer B Gupta, Eugene Hone, James Doecke, Sid O'Bryant, Ian James, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Ralph N Martins

Journal article  |  2017  |  Scientific Reports

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Nanoscale Imaging Reveals Big Role for Iron in Alzheimer's Disease

Scott Ayton, Simon A James, Ashley I Bush

Journal article  |  2017  |  Cell Chemical Biology

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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R Stockwell, Jose Pedro Friedmann Angeli, Hulya Bayir, Ashley I Bush, Marcus Conrad, Scott J Dixon, Simone Fulda, Sergio Gascon, Stavroula K Hatzios, Valerian E Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C Pagnussat, Jason Park, Qitao Ran, Craig S Rosenfeld, et al.

Journal article  |  2017  |  Cell

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Novel in vivo experimental viability assays with high sensitivity and throughput capacity using a bdelloid rotifer

Zita Olah, Ashley I Bush, David Aleksza, Bence Galik, Eszter Ivitz, Lilla Macsai, Zoltan Janka, Zoltan Karman, Janos Kalman, Zsolt Datki

Journal article  |  2017  |  Ecotoxicology and Environmental Safety

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Clinical Quantitative Susceptibility Mapping (QSM): Biometal Imaging and Its Emerging Roles in Patient Care

Yi Wang, Pascal Spincemaille, Zhe Liu, Alexey Dimov, Kofi Deh, Jianqi Li, Yan Zhang, Yihao Yao, Kelly M Gillen, Alan H Wilman, Ajay Gupta, Apostolos John Tsiouris, Ilhami Kovanlikaya, Gloria Chia-Yi Chiang, Jonathan W Weinsaft, Lawrence Tanenbaum, Weiwei Chen, Wenzhen Zhu, Shixin Chang, Min Lou, et al.

Journal article  |  2017  |  Journal of Magnetic Resonance Imaging

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Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice

Shijie Liu, Yu Shen, Sandy R Shultz, Nguyen Anne, Christopher Hovens, Paul A Adlard, Ashley I Bush, Jianxiong Chan, Patrick Kwan, Terence J O'Brien, Nigel C Jones

Journal article  |  2017  |  Epilepsia

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Amyloidogenic processing of beta-amyloid precursor protein promotes ferroptosis: implications for Alzheimer's disease

J Duce, B Wong, A Tsatsanis, A Gunn, L Lam, S Ayton, D Devos, A Bush

Conference Proceedings  |  2017  |  JOURNAL OF NEUROCHEMISTRY

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URATE OFFSETS MANGANESE-INDUCED IRON DYSHOMEOSTASIS AND NEURONAL DEGENERATION

Rachit Bakshi, Vivek Venkataramani, Sanghamitra Bandyopadhyay, Yadong Huang, Yanyan Liu, Xudong Huang, Ashley Bush, Catherine Cahill, Debomoy Lahiri, Hong Jiang, Fudi Wang, Ann Smith, Jack Rogers

Conference Proceedings  |  2017  |  AMERICAN JOURNAL OF HEMATOLOGY

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The role of copper in ubiquitin-dependent protein degradation in Alzheimer's disease

M Greenough, C Opazo, A Bush

Conference Proceedings  |  2017  |  JOURNAL OF NEUROCHEMISTRY

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Cerebral quantitative susceptibility mapping predicts amyloid-beta-related cognitive decline

Scott Ayton, Amir Fazlollahi, Pierrick Bourgeat, Parnesh Raniga, Amanda Ng, Yen Ying Lim, Ibrahima Diouf, Shawna Farquharson, Jurgen Fripp, David Ames, James Doecke, Patricia Desmond, Roger Ordidge, Colin L Masters, Christopher C Rowe, Paul Maruff, Victor L Villemagne, Olivier Salvado, Ashley I Bush

Journal article  |  2017  |  Brain

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Extracellular Zn2 Is Essential for Amyloid beta(1-42)-Induced Cognitive Decline in the Normal Brain and Its Rescue

Atsushi Takeda, Haruna Tamano, Munekazu Tempaku, Miku Sasaki, Chihiro Uematsu, Shoko Sato, Hiroaki Kanazawa, Zsolt L Datki, Paul A Adlard, Ashley I Bush

Journal article  |  2017  |  The Journal of Neuroscience

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The APOE epsilon 4 Allele Is Associated with Lower Selenium Levels in the Brain: Implications for Alzheimer's Disease

Barbara R Cardoso, Dominic J Hare, Monica Lind, Catriona A McLean, Irene Volitakis, Simon M Laws, Colin L Masters, Ashley I Bush, Blaine R Roberts

Journal article  |  2017  |  ACS Chemical Neuroscience

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The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

David I Finkelstein, Jessica L Billings, Paul A Adlard, Scott Ayton, Amelia Sedjahtera, Colin L Masters, Simon Wilkins, David M Shackleford, Susan A Charman, Wojciech Bal, Izabela A Zawisza, Ewa Kurowska, Andrew L Gundlach, Sheri Ma, Ashley I Bush, Dominic J Hare, Philip A Doble, Simon Crawford, Elisabeth CL Gautier, Jack Parsons, et al.

Journal article  |  2017  |  Acta Neuropathologica Communications

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Tat-haFGF(14-154) Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1 alpha/XBP1 Pathway

Tian Meng, Qin Cao, Peng Lei, Ashley I Bush, Qi Xiang, Zhijian Su, Xiang He, Jack T Rogers, Ing-Ming Chiu, Qihao Zhang, Yadong Huang

Journal article  |  2017  |  Molecular Therapy - Nucleic Acids

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Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry

Soumya Mukherjee, Eugene A Kapp, Amber Lothian, Anne M Roberts, Yury V Vasil'ev, Berin A Boughton, Kevin J Barnham, W Mei Kok, Craig A Hutton, Colin L Masters, Ashley I Bush, Joseph S Beckmann, Somdatta Ghosh Dey, Blaine R Roberts

Journal article  |  2017  |  Analytical Chemistry

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Biometals in neurodegenerative diseases: mechanisms and therapeutics

AR White, M Aschner, LG Costa, AI Bush

Book  |  2017

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Preface

AR White, M Aschner, LG Costa, AI Bush

Book  |  2017

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Editorial: The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation

Marialessandra Contino, Elena Capparelli, Nicola A Colabufo, Ashley I Bush

Journal article  |  2017  |  Frontiers in Neuroscience

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Whole-brain metallomic analysis of the common marmoset (Callithrix jacchus)

B Knauer, P Majka, KJ Watkins, AWR Taylor, D Malamanova, B Paul, Hsin-Hao Yu, AI Bush, DJ Hare, DH Reser

Journal article  |  2017  |  Metallomics

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Cognitive effects of adjunctive N-acetyl cysteine in psychosis

M Rapado-Castro, S Dodd, AI Bush, GS Malhi, DR Skvarc, ZX On, M Berk, OM Dean

Journal article  |  2017  |  Psychological Medicine

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The Copper bis(thiosemicarbazone) Complex Cu-II(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu

Mikko T Huuskonen, Qing-zhang Tuo, Sanna Loppi, Hiramani Dhungana, Paula Korhonen, Lachlan E McInnes, Paul S Donnelly, Alexandra Grubman, Sara Wojciechowski, Katarina Lejavova, Yuriy Pomeshchik, Laura Periviita, Lotta Kosonen, Martina Giordano, Frederick R Walker, Rong Liu, Ashley I Bush, Jari Koistinaho, Tarja Malm, Anthony R White, et al.

Journal article  |  2017  |  Neurotherapeutics

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Oxidation of Iron under Physiologically Relevant Conditions in Biological Fluids from Healthy and Alzheimer's Disease Subjects

Linh Q Lam, Bruce X Wong, Tony Frugier, Qao-Xin Li, Steven J Collins, Ashley I Bush, Peter J Crack, James A Duce

Journal article  |  2017  |  ACS Chemical Neuroscience

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Glutathione peroxidase 4: a new player in neurodegeneration?

BR Cardoso, DJ Hare, AI Bush, BR Roberts

Journal article  |  2017  |  Molecular Psychiatry

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Ferroptosis and cell death mechanisms in Parkinson's disease

Stephanie J Guiney, Paul A Adlard, Ashley I Bush, David I Finkelstein, Scott Ayton

Journal article  |  2017  |  Neurochemistry International

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Lithium suppression of tau induces brain iron accumulation and neurodegeneration

P Lei, S Ayton, AT Appukuttan, S Moon, JA Duce, I Volitakis, R Cherny, SJ Wood, M Greenough, G Berger, C Pantelis, P McGorry, A Yung, DI Finkelstein, AI Bush

Journal article  |  2017  |  Molecular Psychiatry

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Altered levels of blood proteins in Alzheimer's disease longitudinal study: Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort.

Veer Bala Gupta, Eugene Hone, Steve Pedrini, James Doecke, Sid O'Bryant, Ian James, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Ralph N Martins, undefined AIBL Research Group

Journal article  |  2017  |  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

INTRODUCTION: A blood-based biomarker panel to identify individuals with preclinical Alzheimer's disease (AD) would be an inexpens..

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Metalloregulation of Protein Clearance: New Therapeutic Avenues for Neurodegenerative Diseases

Alejandra Ramirez Munoz, Mark A Greenough, Ashley I Bush, Carlos M Opazo

Book Chapter  |  2017

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No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease

Michelle K Lupton, Beben Benyamin, Petroula Proitsi, Dale R Nyholt, Manuel A Ferreira, Grant W Montgomery, Andrew C Heath, Pamela A Madden, Sarah E Medland, Scott D Gordon, Simon Lovestone, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, John F Powell, Ashley I Bush, Margaret J Wright, Nicholas G Martin, et al.

Journal article  |  2017  |  Journal of Alzheimer's Disease

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Amyloid Precursor Protein Haploinsufficiency Preferentially Mediates Brain Iron Accumulation in Mice Transgenic for The Huntington's Disease Mutation

Kiersten Berggren, Sonal Agrawal, Julia A Fox, Justin Hildenbrand, Ryan Nelson, Ashley I Bush, Jonathan H Fox

Journal article  |  2017  |  Journal of Huntington's Disease

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The Role of Selenium in Neurodegenerative Diseases

Barbara R Cardoso, Dominic J Hare, Ashley I Bush

Book Chapter  |  2017

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Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer's Disease Patients: A Report from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL)

Barbara R Cardoso, Dominic J Hare, Ashley I Bush, Qiao-Xin Li, Christopher J Fowler, Colin L Masters, Ralph N Martins, Katherine Ganio, Amber Lothian, Soumya Mukherjee, Eugene A Kapp, Blaine R Roberts

Journal article  |  2017  |  Journal of Alzheimer's Disease

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Association of Cerebrospinal Fluid Ferritin Level With Preclinical Cognitive Decline in APOE-epsilon 4 Carriers

Scott Ayton, Noel G Faux, Ashley I Bush

Journal article  |  2017  |  JAMA Neurology

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Evidence of a Cardiovascular Function for Microtubule-Associated Protein Tau

Ashenafi H Betrie, Scott Ayton, Ashley I Bush, James A Angus, Peng Lei, Christine E Wright

Journal article  |  2017  |  Journal of Alzheimer's Disease

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Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS)

Dominic J Hare, Kai Kysenius, Bence Paul, Beate Knauer, Robert W Hutchinson, Ciaran O'Connor, Fred Fryer, Tom P Hennessey, Ashley I Bush, Peter J Crouch, Philip A Doble

Journal article  |  2017  |  Journal of Visualized Experiments

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Targeting Transition Metals for Neuroprotection in Alzheimer's Disease

S Ayton, AA Belaidi, P Lei, AI Bush

Book Chapter  |  2017

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Rubidium and potassium levels are altered in Alzheimer's disease brain and blood but not in cerebrospinal fluid

Blaine R Roberts, James D Doecke, Alan Rembach, L Fernanda Yevenes, Christopher J Fowler, Catriona A McLean, Monica Lind, Irene Volitakis, Colin L Masters, Ashley I Bush, Dominic J Hare

Journal article  |  2016  |  Acta Neuropathologica Communications

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The Complex Role of Apolipoprotein E in Alzheimer's Disease: an Overview and Update

Laura Mahoney-Sanchez, Abdel Ali Belaidi, Ashley I Bush, Scott Ayton

Journal article  |  2016  |  Journal of Molecular Neuroscience

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Delivery of Fluorescent Nanoparticles to the Brain

Olga Shimoni, Bingyang Shi, Paul A Adlard, Ashley I Bush

Journal article  |  2016  |  Journal of Molecular Neuroscience

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Dementia Research Australia: the Australian Dementia Research Development Fellowship Program

Ashley I Bush, George Fink, Peng Lei

Journal article  |  2016  |  Journal of Molecular Neuroscience

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Context matters: communicating the need for biomarkers for mental illnesses to the general public

Melanie Carew, Brian Dean, Ashley I Bush, Ian Cooke

Journal article  |  2016  |  Australasian Psychiatry

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Amyloid beta attenuates metabotropic zinc sensing receptor, mZnR/GPR39, dependent Ca2 , ERK1/2 and Clusterin signaling in neurons

Chen Abramovitch-Dahan, Hila Asraf, Milos Bogdanovic, Israel Sekler, Ashley I Bush, Michal Hershfinkel

Journal article  |  2016  |  Journal of Neurochemistry

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Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

Abdel A Belaidi, Ashley I Bush

Journal article  |  2016  |  Journal of Neurochemistry

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Predicting Alzheimer disease from a blood-based biomarker profile: A 54-month follow-up

Samantha C Burnham, Christopher C Rowe, David Baker, Ashley I Bush, James D Doecke, Noel G Faux, Simon M Laws, Ralph N Martins, Paul Maruff, S Lance Macaulay, Stephanie Rainey-Smith, Greg Savage, David Ames, Colin L Masters, William Wilson, Victor L Villemagne

Journal article  |  2016  |  Neurology

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Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex

Dominic J Hare, Erika P Raven, Blaine R Roberts, Mirjana Bogeski, Stuart D Portbury, Catriona A McLean, Colin L Masters, James R Connor, Ashley I Bush, Peter J Crouch, Philip A Doble

Journal article  |  2016  |  NeuroImage

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Involvement of hippocampal excitability in amyloid beta-induced behavioral and psychological symptoms of dementia

Haruna Tamano, Kazuki Ide, Paul Anthony Adlard, Ashley Ian Bush, Atsushi Takeda

Journal article  |  2016  |  The Journal of Toxicological Sciences

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Neurological Dysfunction in Early Maturity of a Model for Niemann-Pick C1 Carrier Status

Ya Hui Hung, Mark Walterfang, Leonid Churilov, Lisa Bray, Laura H Jacobson, Kevin J Barnham, Nigel C Jones, Terence J O'Brien, Dennis Velakoulis, Ashley I Bush

Journal article  |  2016  |  Neurotherapeutics

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Upregulation of zinc transporter, solute carrier family 39, member 12, in the cortex of subjects with schizophrenia

M Udawela, B Dean, M Greenough, T Money, MS Seo, A Bush, E Scarr

Conference Proceedings  |  2016  |  INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

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phi XANES: In vivo imaging of metal-protein coordination environments (vol 6, 20350, 2016)

Simon A James, Dominic J Hare, Nicole L Jenkins, Martin D de Jonge, Ashley I Bush, Gawain McColl

Journal article  |  2016  |  Scientific Reports

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Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia

Elizabeth Scarr, Madhara Udawela, Mark A Greenough, Jaclyn Neo, Myoung Suk Seo, Tammie T Money, Aradhana Upadhyay, Ashley I Bush, Ian P Everall, Elizabeth A Thomas, Brian Dean

Journal article  |  2016  |  npj Schizophrenia

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MANGANESE NEUROTOXICITY DERIVES IN PART FROM PERTURBED FE/IRE/IRP REGULATION IN RATS AND MODELS OF HUMAN NEURONS

Vivek Venkataramani, Yanyan Liu, Catherine Cahill, Katharina Fernsebner, Bernhard Michalke, Hong Jiang, Scott Ayton, Ashley Bush, Xudong Huang, Jack Rogers

Conference Proceedings  |  2016  |  AMERICAN JOURNAL OF HEMATOLOGY

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Effects of Neonatal Iron Feeding and Chronic Clioquinol Administration on the Parkinsonian Human A53T Transgenic Mouse

Jessica L Billings, Dominic J Hare, Milawaty Nurjono, Irene Volitakis, Robert A Cherny, Ashley I Bush, Paul A Adlard, David I Finkelstein

Journal article  |  2016  |  ACS Chemical Neuroscience

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phi XANES: In vivo imaging of metal-protein coordination environments

Simon A James, Dominic J Hare, Nicole L Jenkins, Martin D de Jonge, Ashley I Bush, Gawain McColl

Journal article  |  2016  |  Scientific Reports

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Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice

DI Finkelstein, DJ Hare, JL Billings, A Sedjahtera, M Nurjono, E Arthofer, S George, JG Culvenor, AI Bush, PA Adlard

Journal article  |  2016  |  ACS Chemical Neuroscience

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Overexpression of Metallothionein-1 Modulates the Phenotype of the Tg2576 Mouse Model of Alzheimer's Disease

Yasmina Manso, Gemma Comes, Juan C Lopez-Ramos, Monica Belfiore, Amalia Molinero, Mercedes Giralt, Javier Carrasco, Paul A Adlard, Ashley I Bush, Jose Maria Delgado-Garcia, Juan Hidalgo

Journal article  |  2016  |  Journal of Alzheimer's Disease

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Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging.

Veer Bala Gupta, James D Doecke, Eugene Hone, Steve Pedrini, Simon M Laws, Madhav Thambisetty, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Stuart Lance Macaulay, Alan Rembach, Stephanie R Rainey-Smith, Ralph N Martins, undefined AIBL Research Group

Journal article  |  2016  |  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

INTRODUCTION: For early detection of Alzheimer's disease (AD), the field needs biomarkers that can be used to detect disease statu..

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Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice

David I Finkelstein, Dominic J Hare, Jessica L Billings, Amelia Sedjahtera, Milawaty Nurjono, Elisa Arthofer, Sonia George, Janetta G Culvenor, Ashley I Bush, Paul A Adlard

Journal article  |  2016  |  ACS chemical neuroscience

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Human Basic Fibroblast Growth Factor Inhibits Tau Phosphorylation via the PI3K/Akt-GSK3 beta Signaling Pathway in a 6-Hydroxydopamine-Induced Model of Parkinson's Disease

Peng-hui Yang, Jian-xiu Zhu, Ya-dong Huang, Xian-ying Zhang, Peng Lei, Ashley I Bush, Qi Xiang, Zhi-jian Su, Qi-hao Zhang

Journal article  |  2016  |  Neurodegenerative Diseases

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Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing

Dominic J Hare, Noel G Faux, Blaine R Roberts, Irene Volitakis, Ralph N Martins, Ashley I Bush

Journal article  |  2016  |  Metallomics

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Metallo-pathways to Alzheimer's disease: lessons from genetic disorders of copper trafficking

MA Greenough, A Ramirez Munoz, AI Bush, CM Opazo

Journal article  |  2016  |  Metallomics

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High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans

Dominic J Hare, Michael WM Jones, Verena C Wimmer, Nicole L Jenkins, Martin D de Jonge, Ashley I Bush, Gawain McColl

Journal article  |  2016  |  Metallomics

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Iron Regulates Apolipoprotein E Expression and Secretion in Neurons and Astrocytes

He Xu, Victoria M Perreau, Krista A Dent, Ashley I Bush, David I Finkelstein, Paul A Adlard

Journal article  |  2016  |  Journal of Alzheimer's Disease

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Bis(thiosemicarbazone) Metal Complexes as Therapeutics for Neurodegenerative Diseases

S Mckenzie-Nickson, AI Bush, KJ Barnham

Journal article  |  2016  |  Current Topics in Medicinal Chemistry

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Amyloid-Beta Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization and Calcium-Influx in Neurons

A BUSH, AP Gunn, BX Wong, T Johanssen, JC Griffith, CL Masters, KJ Barnham, JA Duce, RA Cherny

Journal article  |  2016  |  Journal of Biological Chemistry

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Transferrin protects against Parkinsonian neurotoxicity and is deficient in Parkinson's substantia nigra

Scott Ayton, Peng Lei, Catriona Mclean, Ashley Bush, David Finkelstein

Journal article  |  2016  |  Signal Transduction and Targeted Therapy

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Benefits of adjunctive N-acetylcysteine in a sub-group of clozapine-treated individuals diagnosed with schizophrenia

Olivia M Dean, Serafino G Mancuso, Ashley I Bush, David Copolov, Kim Q Do, Michel Cuenod, Philippe Conus, Susan L Rossell, David J Castle, Michael Berk

Journal article  |  2015  |  Psychiatry Research

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Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of beta-Amyloid Toxicity and Are Mediated by Tau

Xuling Li, Peng Lei, Qingzhang Tuo, Scott Ayton, Qiao-Xin Li, Steve Moon, Irene Volitakis, Rong Liu, Colin L Masters, David I Finkelstein, Ashley I Bush

Journal article  |  2015  |  Neurotherapeutics

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Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way

He Xu, Veer B Gupta, Ian J Martins, Ralph N Martins, Christopher J Fowler, Ashley I Bush, David I Finkelstein, Paul A Adlard

Journal article  |  2015  |  Neurobiology of Disease

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Is early-life iron exposure critical in neurodegeneration?

Dominic J Hare, Manish Arora, Nicole L Jenkins, David I Finkelstein, Philip A Doble, Ashley I Bush

Journal article  |  2015  |  Nature Reviews Neurology

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Novel Fluorinated 8-Hydroxyquinoline Based Metal Ionophores for Exploring the Metal Hypothesis of Alzheimer's Disease

Steven H Liang, Adam G Southon, Benjamin H Fraser, Anwen M Krause-Heuer, Bo Zhang, Timothy M Shoup, Rebecca Lewis, Irene Volitakis, Yifeng Han, Ivan Greguric, Ashley I Bush, Neil Vasdev

Journal article  |  2015  |  ACS Medicinal Chemistry Letters

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Metal chaperones prevent zinc-mediated cognitive decline

Paul A Adlard, Jacqui Parncutt, Varsha Lal, Simon James, Dominic Hare, Philip Doble, David I Finkelstein, Ashley I Bush

Journal article  |  2015  |  Neurobiology of Disease

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Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

Peng Lei, Scott Ayton, Ambili Thoppuvalappil Appukuttan, Irene Volitakis, Paul A Adlard, David I Finkelstein, Ashley I Bush

Journal article  |  2015  |  Neurobiology of Disease

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Selenium as a potential biomarker for Alzheimer's disease

B Cardoso, B Roberts, A Bush, D Hare

Conference Proceedings  |  2015  |  JOURNAL OF NEUROCHEMISTRY

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Characterizing how post translational modifications can alter the serine protease inhibition of the KPI domain in app

B Wong, A Bush, J Duce

Conference Proceedings  |  2015  |  JOURNAL OF NEUROCHEMISTRY

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The sex-specific role of biometals in the risk of Parkinson's disease

MJ Kim, JY Lee, J Kim, K Kim, HS Ryu, AI Bush, SJ Chung

Conference Proceedings  |  2015  |  MOVEMENT DISORDERS

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Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

Scott Ayton, Noel G Faux, Ashley I Bush

Journal article  |  2015  |  Nature Communications

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Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington's disease

Kiersten L Berggren, Jianfang Chen, Julia Fox, Jonathan Miller, Lindsay Dodds, Bryan Dugas, Liset Vargas, Amber Lothian, Erin McAllum, Irene Volitakis, Blaine Roberts, Ashley I Bush, Jonathan H Fox

Journal article  |  2015  |  Redox Biology

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Towards stage specific treatments: Effects of duration of illness on therapeutic response to adjunctive treatment with N-acetyl cysteine in schizophrenia

Marta Rapado-Castro, Michael Berk, Kamalesh Venugopal, Ashley I Bush, Seetal Dodd, Olivia M Dean

Journal article  |  2015  |  PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

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Decreased Plasma Iron in Alzheimer's Disease Is Due to Transferrin Desatu ration

Dominic J Hare, James D Doecke, Noel G Faux, Alan Rembach, Irene Volitakis, Christopher J Fowler, Rudolf Grimm, Philip A Doble, Robert A Cherny, Colin L Masters, Ashley I Bush, Blame R Roberts

Journal article  |  2015  |  ACS Chemical Neuroscience

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Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of beta-Amyloid Precursor Protein

Scott Ayton, Peng Lei, Dominic J Hare, James A Duce, Jessica L George, Paul A Adlard, Catriona McLean, Jack T Rogers, Robert A Cherny, David I Finkelstein, Ashley I Bush

Journal article  |  2015  |  Journal of Neuroscience

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Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort

Veer B Gupta, Andrea C Wilson, Samantha Burnham, Eugene Hone, Steve Pedrini, Simon M Laws, Wei Ling Florence Lim, Alan Rembach, Stephanie Rainey-Smith, David Ames, Lynne Cobiac, S Lance Macaulay, Colin L Masters, Christopher C Rowe, Ashley I Bush, Ralph N Martins

Journal article  |  2015  |  Alzheimer's Research & Therapy

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Selenium, selenoproteins and neurodegenerative diseases

Barbara Rita Cardoso, Blaine R Roberts, Ashley I Bush, Dominic J Hare

Journal article  |  2015  |  Metallomics

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Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans

Simon A James, Blaine R Roberts, Dominic J Hare, Martin D de Jonge, Ian E Birchall, Nicole L Jenkins, Robert A Cherny, Ashley I Bush, Gawain McColl

Journal article  |  2015  |  Chemical Science

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Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging (vol 6, pg 5383, 2015)

Bence Paul, Dominic J Hare, David P Bishop, Chad Paton, Tran Nguyen Van, Nerida Cole, Megan M Niedzwiecki, Erica Andreozzi, Angela Vais, Jessica L Billings, Lisa Bray, Ashley I Bush, Gawain McColl, Blaine R Roberts, Paul A Adlard, David I Finkelstein, John Hellstrom, Janet M Hergt, Jon D Woodhead, Philip A Doble

Journal article  |  2015  |  Chemical Science

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High Order W02-Reactive Stable Oligomers of Amyloid-beta are Produced in vivo and in vitro via Dialysis and Filtration of Synthetic Amyloid-beta Monomer

Elysia Robb, Keyla Perez, Lin W Hung, Colin L Masters, Kevin J Barnham, Robert A Cherny, Ashley I Bush, Paul A Adlard, David I Finkelstein

Journal article  |  2015  |  Journal of Alzheimer's Disease

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Biometals and Their Therapeutic Implications in Alzheimer's Disease

Scott Ayton, Peng Lei, Ashley I Bush

Journal article  |  2015  |  Neurotherapeutics

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A mouse model of Alzheimer's disease displays increased susceptibility to kindling and seizure-associated death

AI BUSH, J Chan, NC Jones, TJ O'Brien, P Kwan

Journal article  |  2015  |  Epilepsia

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Traumatic brain injury induces elevation of Co in the human brain

Blaine R Roberts, Dominic J Hare, Catriona A McLean, Alison Conquest, Monica Lind, Qiao-Xin Li, Ashley I Bush, Colin L Masters, Maria-Christina Morganti-Kossmann, Tony Frugier

Journal article  |  2015  |  Metallomics

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Amyloid beta-Mediated Zn2 Influx into Dentate Granule Cells Transiently Induces a Short-Term Cognitive Deficit

Atsushi Takeda, Masatoshi Nakamura, Hiroaki Fujii, Chihiro Uematsu, Tatsuya Minamino, Paul A Adlard, Ashley I Bush, Haruna Tamano

Journal article  |  2014  |  PLoS ONE

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Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons

Patricio A Castro, Alejandra Ramirez, Fernando J Sepulveda, Christian Peters, Humberto Fierro, Javier Waldron, Sandra Luza, Jorge Fuentealba, Francisco J Munoz, Giancarlo V De Ferrari, Ashley I Bush, Luis G Aguayo, Carlos M Opazo

Journal article  |  2014  |  Frontiers in Aging Neuroscience

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beta-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

Bruce X Wong, Andrew Tsatsanis, Linh Q Lim, Paul A Adlard, Ashley I Bush, James A Duce

Journal article  |  2014  |  PLoS ONE

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A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe2 under physiologically relevant conditions

Bruce X Wong, Scott Ayton, Linh Q Lam, Peng Lei, Paul A Adlard, Ashley I Bush, James A Duce

Journal article  |  2014  |  Biochimica et Biophysica Acta (BBA) - General Subjects

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An anemia of Alzheimer's disease

NG Faux, A Rembach, J Wiley, KA Ellis, D Ames, CJ Fowler, RN Martins, KK Pertile, RL Rumble, B Trounson, CL Masters, AI Bush

Journal article  |  2014  |  Molecular Psychiatry

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Altered selenium status in Huntington's disease: Neuroprotection by selenite in the N171-82Q mouse model

Zhen Lu, Eileen Marks, Jianfang Chen, Jenna Moline, Lorraine Barrows, Merl Raisbeck, Irene Volitakis, Robert A Cherny, Vanita Chopra, Ashley I Bush, Steven Hersch, Jonathan H Fox

Journal article  |  2014  |  Neurobiology of Disease

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Influence of BDNF Val66Met on the relationship between physical activity and brain volume

Belinda M Brown, Pierrick Bourgeat, Jeremiah J Peiffer, Samantha Burnham, Simon M Laws, Stephanie R Rainey-Smith, David Bartres-Faz, Victor L Villemagne, Kevin Taddei, Alan Rembach, Ashley Bush, Kathryn A Ellis, S Lance Macaulay, Christopher C Rowe, David Ames, Colin L Masters, Paul Maruff, Ralph N Martins

Journal article  |  2014  |  Neurology

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The clinical implications of impaired zinc signaling in the brain

SM Hancock, AI Bush, PA Adlard

Book Chapter  |  2014

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Dietary and lifestyle guidelines for the prevention of Alzheimer's disease

Neal D Barnard, Ashley I Bush, Antonia Ceccarelli, James Cooper, Celeste A de Jager, Kirk I Erickson, Gary Fraser, Shelli Kesler, Susan M Levin, Brendan Lucey, Martha Clare Morris, Rosanna Squitti

Journal article  |  2014  |  Neurobiology of Aging

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An increased neutrophil-lymphocyte ratio in Alzheimer's disease is a function of age and is weakly correlated with neocortical amyloid accumulation

Alan Rembach, Andrew D Watt, William J Wilson, Stephanie Rainey-Smith, Kathryn A Ellis, Christopher C Rowe, Victor L Villemagne, S Lance Macaulay, Ashley I Bush, Ralph N Martins, David Ames, Colin L Masters, James D Doecke

Journal article  |  2014  |  Journal of Neuroimmunology

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Motor and cognitive deficits in aged tau knockout mice in two background strains

Peng Lei, Scott Ayton, Steve Moon, Qihao Zhang, Irene Volitakis, David I Finkelstein, Ashley I Bush

Journal article  |  2014  |  Molecular Neurodegeneration

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beta-amyloid in biological samples: not all A beta detection methods are created equal

Paul A Adlard, Qiao-Xin Li, Catriona McLean, Colin L Masters, Ashley I Bush, Michelle Fodero-Tavoletti, Victor Villemagne, Kevin J Barnham

Journal article  |  2014  |  Frontiers in Aging Neuroscience

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Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease

Scott Ayton, Peng Lei, Paul A Adlard, Irene Volitakis, Robert A Cherny, Ashley I Bush, David I Finkelstein

Journal article  |  2014  |  Molecular Neurodegeneration

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Copper: from neurotransmission to neuroproteostasis

Carlos M Opazo, Marka A Greenough, Ashley I Bush

Journal article  |  2014  |  Frontiers in Aging Neuroscience

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Oral Treatment with Cu-II(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Blaine R Roberts, Nastasia KH Lim, Erin J McAllum, Paul S Donnelly, Dominic J Hare, Philip A Doble, Bradley J Turner, Katherine A Price, Sin Chun Lim, Brett M Paterson, James L Hickey, Timothy W Rhoads, Jared R Williams, Katja M Kanninen, Lin W Hung, Jeffrey R Liddell, Alexandra Grubman, Jean-Francois Monty, Roxana M Llanos, David R Kramer, et al.

Journal article  |  2014  |  Journal of Neuroscience

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The Efficacy of Adjunctive N-Acetylcysteine in Major Depressive Disorder: A Double-Blind, Randomized, Placebo-Controlled Trial

Michael Berk, Olivia M Dean, Sue M Cotton, Susan Jeavons, Michelle Tanious, Kristy Kohlmann, Karen Hewitt, Kirsteen Moss, Christine Allwang, Ian Schapkaitz, Jenny Robbins, Heidi Cobb, Felicity Ng, Seetal Dodd, Ashley I Bush, Gin S Malhi

Journal article  |  2014  |  Journal of Clinical Psychiatry

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RESPONSE TO COMMENT ON MOORE ET AL. Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin. Diabetes Care 2013;36:2981-2987

Eileen M Moore, Alastair G Mander, David Ames, Mark A Kotowicz, Ross P Carne, Henry Brodaty, Michael Woodward, Kathryn A Ellis, Ashley I Bush, Noel G Faux, David A Watters

Journal article  |  2014  |  Diabetes Care

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Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology

Bruce X Wong, Ya Hui Hung, Ashley I Bush, James A Duce

Journal article  |  2014  |  Frontiers in Aging Neuroscience

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Therapeutic protein supplementation corrects iron export fatigue in Parkinson's disease

S Ayton, P Lei, DI Finkelstein, AI Bush

Conference Proceedings  |  2014  |  MOVEMENT DISORDERS

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Phosphorylation of Amyloid Precursor Protein at Threonine 668 Is Essential for Its Copper-responsive Trafficking in SH-SY5Y Neuroblastoma Cells

Karla M Acevedo, Carlos M Opazo, David Norrish, Leesa M Challis, Qiao-Xin Li, Anthony R White, Ashley I Bush, James Camakaris

Journal article  |  2014  |  Journal of Biological Chemistry

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A novel approach to rapidly prevent age-related cognitive decline

Paul A Adlard, Amelia Sedjahtera, Lydia Gunawan, Lisa Bray, Dominic Hare, Jessica Lear, Philip Doble, Ashley I Bush, David I Finkelstein, Robert A Cherny

Journal article  |  2014  |  Aging Cell

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Ceruloplasmin and beta-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron

Scott Ayton, Moses Zhang, Blaine R Roberts, Linh Q Lam, Monica Lind, Catriona McLean, Ashley I Bush, Tony Frugier, Peter J Crack, James A Duce

Journal article  |  2014  |  Free Radical Biology and Medicine

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EFFECTS OF DURATION OF ILLNESS ON THERAPEUTIC RESPONSE TO ADJUNCTIVE TREATMENT WITH N-ACETYL CYSTEINE IN SCHIZOPHRENIA

Marta Rapado-Castro, Michael Berk, Kamalesh Venugopal, Ashley Ian Bush, Seetal Dood, Olivia M Dean

Conference Proceedings  |  2014  |  SCHIZOPHRENIA RESEARCH

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Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL)

Kathryn A Ellis, Cassandra Szoeke, Ashley I Bush, David Darby, Petra L Graham, Nicola T Lautenschlager, S Lance Macaulay, Ralph N Martins, Paul Maruff, Colin L Masters, Simon J McBride, Kerryn E Pike, Stephanie R Rainey-Smith, Alan Rembach, Joanne Robertson, Christopher C Rowe, Greg Savage, Victor L Villemagne, Michael Woodward, William Wilson, et al.

Journal article  |  2014  |  International Psychogeriatrics

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A blood-based predictor for neocortical A beta burden in Alzheimer's disease: results from the AIBL study

SC Burnham, NG Faux, W Wilson, SM Laws, D Ames, J Bedo, Ai Bush, JD Doecke, KA Ellis, R Head, G Jones, H Kiiveri, RN Martins, A Rembach, CC Rowe, O Salvado, SL Macaulay, CL Masters, VL Villemagne

Journal article  |  2014  |  Molecular Psychiatry

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Alzheimer's disease and Parkinson's disease: archetypal disorders of brain metal homeostasis

AI Bush

Conference Proceedings  |  2014  |  JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

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The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue

Dominic J Hare, Jessica L George, Lisa Bray, Irene Volitakis, Angela Vais, Timothy M Ryan, Robert A Cherny, Ashley I Bush, Colin L Masters, Paul A Adlard, Philip A Doble, David I Finkelstein

Journal article  |  2014  |  Journal of Analytical Atomic Spectrometry

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Effect of BDNF Val66Met on Memory Decline and Hippocampal Atrophy in Prodromal Alzheimer's Disease: A Preliminary Study

Yen Ying Lim, Victor L Villemagne, Simon M Laws, David Ames, Robert H Pietrzak, Kathryn A Ellis, Karra Harrington, Pierrick Bourgeat, Ashley I Bush, Ralph N Martins, Colin L Masters, Christopher C Rowe, Paul Maruff

Journal article  |  2014  |  PLoS One

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Among Vitamin B12 Deficient Older People, High Folate Levels are Associated with Worse Cognitive Function: Combined Data from Three Cohorts

Eileen M Moore, David Ames, Alastair G Mander, Ross P Carne, Henry Brodaty, Michael C Woodward, Karyn Boundy, Kathryn A Ellis, Ashley I Bush, Noel G Faux, Ralph N Martins, Colin L Masters, Christopher C Rowe, Cassandra Szoeke, David A Watters

Journal article  |  2014  |  Journal of Alzheimer's Disease

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Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid beta

Mingfeng Yu, Timothy M Ryan, Samantha Ellis, Ashley I Bush, James A Triccas, Peter J Rutledge, Matthew H Todd

Journal article  |  2014  |  Metallomics

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Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease

Alan Rembach, Noel G Faux, Andrew D Watt, Kelly K Pertile, Rebecca L Rumble, Brett O Trounson, Christopher J Fowler, Blaine R Roberts, Keyla A Perez, Qiao-Xin Li, Simon M Laws, Kevin Taddei, Stephanie Rainey-Smith, Joanne S Robertson, Manu Vandijck, Hugo Vanderstichele, Kevin J Barnham, Kathryn A Ellis, Cassandra Szoeke, Lance Macaulay, et al.

Journal article  |  2014  |  Alzheimers Dement

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A review of β-amyloid neuroimaging in Alzheimer's disease

PA Adlard, BA Tran, DI Finkelstein, PM Desmond, LA Johnston, AI Bush, GF Egan

Journal article  |  2014  |  Frontiers in Neuroscience

Alzheimer's disease (AD) is the most common cause of dementia worldwide. As advancing age is the greatest risk factor for developi..

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Altered transition metal homeostasis in Niemann-Pick disease, type C1

Ya Hui Hung, Noel G Faux, David W Killilea, Nicole Yanjanin, Sally Firnkes, Irene Volitakis, George Ganio, Mark Walterfang, Caroline Hastings, Forbes D Porter, Daniel S Ory, Ashley I Bush

Journal article  |  2014  |  Metallomics: integrated biometal science

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An iron-dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta

Dominic J Hare, Peng Lei, Scott Ayton, Blaine R Roberts, Rudolf Grimm, Jessica L George, David P Bishop, Alison D Beavis, Sarah J Donovan, Gawain McColl, Irene Volitakis, Colin L Masters, Paul A Adlard, Robert A Cherny, Ashley I Bush, David I Finkelstein, Philip A Doble

Journal article  |  2014  |  Chemical Science

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Associations between gonadotropins, testosterone and beta amyloid in men at risk of Alzheimer's disease

G Verdile, SM Laws, D Henley, D Ames, AI Bush, KA Ellis, NG Faux, VB Gupta, Q-X Li, CL Masters, KE Pike, CC Rowe, C Szoeke, K Taddei, VL Villemagne, RN Martins

Journal article  |  2014  |  Molecular Psychiatry

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Meta-Analysis of Serum Non-Ceruloplasmin Copper in Alzheimer's Disease

Rosanna Squitti, Ilaria Simonelli, Mariacarla Ventriglia, Mariacristina Siotto, Patrizio Pasqualetti, Alan Rembach, James Doecke, Ashley I Bush

Journal article  |  2014  |  Journal of Alzheimer's Disease

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Biological metals and metal-targeting compounds in major neurodegenerative diseases

Kevin J Barnham, Ashley I Bush

Journal article  |  2014  |  Chem. Soc. Rev.

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Decreased serum zinc is an effect of ageing and not Alzheimer's disease

Alan Rembach, Dominic J Hare, James D Doecke, Samantha C Burnham, Irene Volitakis, Christopher J Fowler, Robert A Cherny, Catriona McLean, Rudolf Grimm, Ralph Martins, David Ames, Colin L Masters, Ashley I Bush, Blaine R Roberts

Journal article  |  2014  |  Metallomics: integrated biometal science

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Plasma Amyloid-beta Levels are Significantly Associated with a Transition Toward Alzheimer's Disease as Measured by Cognitive Decline and Change in Neocortical Amyloid Burden

Alan Rembach, Andrew D Watt, William J Wilson, Victor L Villemagne, Samantha C Burnham, Kathryn A Ellis, Paul Maruff, David Ames, Christopher C Rowe, S Lance Macaulay, Ashley I Bush, Ralph N Martins, Colin L Masters, James D Doecke

Journal article  |  2014  |  Journal of Alzheimer's Disease

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Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue

Giuseppe D Ciccotosto, Simon A James, Matteo Altissimo, David Paterson, Stefan Vogt, Barry Lai, Martin D de Jonge, Daryl L Howard, Ashley I Bush, Roberto Cappai

Journal article  |  2014  |  Metallomics

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Clinical utility of the cogstate brief battery in identifying cognitive impairment in mild cognitive impairment and Alzheimer's disease.

P Maruff, YY Lim, D Darby, KA Ellis, RH Pietrzak, PJ Snyder, AI Bush, C Szoeke, A Schembri, D Ames, CL Masters

Journal article  |  2013  |  BMC Psychology

Background: Previous studies have demonstrated the utility and sensitivity of the CogState Brief Battery (CBB) in detecting cognit..

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Metallostasis in Alzheimer's disease and Parkinson's disease

A Bush

Conference Proceedings  |  2013  |  JOURNAL OF MOLECULAR NEUROSCIENCE

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Metallostasis in Alzheimer's disease and Parkinson's disease

A Bush

Conference Proceedings  |  2013  |  JOURNAL OF MOLECULAR NEUROSCIENCE

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BDNF Val66Met, A beta amyloid, and cognitive decline in preclinical Alzheimer's disease

Yen Ying Lim, Victor L Villemagne, Simon M Laws, David Ames, Robert H Pietrzak, Kathryn A Ellis, Karra D Harrington, Pierrick Bourgeat, Olivier Salvado, David Darby, Peter J Snyder, Ashley I Bush, Ralph N Martins, Colin L Masters, Christopher C Rowe, Pradeep J Nathan, Paul Maruff

Journal article  |  2013  |  Neurobiology of Aging

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Iron Accumulates in Huntington's Disease Neurons: Protection by Deferoxamine

Jianfang Chen, Eileen Marks, Barry Lai, Zhaojie Zhang, James A Duce, Linh Q Lam, Irene Volitakis, Ashley I Bush, Steven Hersch, Jonathan H Fox

Journal article  |  2013  |  PLoS ONE

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N-Acetyl cysteine as a potential tobacco use cessation agent in bipolar disorder and schizophrenia

M Rapado-Castro, S Dodd, O Dean, ZX On, AI Bush, M Berk

Conference Proceedings  |  2013  |  European Neuropsychopharmacology

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Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin

Eileen M Moore, Alastair G Mander, David Ames, Mark A Kotowicz, Ross P Carne, Henry Brodaty, Michael Woodward, Karyn Boundy, Kathryn A Ellis, Ashley I Bush, Noel G Faux, Ralph Martins, Cassandra Szoeke, Christopher Rowe, David A Watters

Journal article  |  2013  |  Diabetes Care

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Metallostasis in Alzheimer's disease

Scott Ayton, Peng Lei, Ashley I Bush

Journal article  |  2013  |  Free Radical Biology and Medicine

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Clioquinol Synergistically Augments Rescue by Zinc Supplementation in a Mouse Model of Acrodermatitis Enteropathica

Jim Geiser, Robert C De Lisle, David Finkelstein, Paul A Adlard, Ashley I Bush, Glen K Andrews

Journal article  |  2013  |  PLoS One

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Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing.

BM Brown, JJ Peiffer, K Taddei, JK Lui, SM Laws, VB Gupta, T Taddei, VK Ward, MA Rodrigues, S Burnham, SR Rainey-Smith, VL Villemagne, A Bush, KA Ellis, CL Masters, D Ames, SL Macaulay, C Szoeke, CC Rowe, RN Martins

Journal article  |  2013  |  Molecular Psychiatry

Previous studies suggest physical activity improves cognition and lowers Alzheimer's disease (AD) risk. However, key AD pathogenic..

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Physical activity and amyloid-beta plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing

BM Brown, JJ Peiffer, K Taddei, JK Lui, SM Laws, VB Gupta, T Taddei, VK Ward, MA Rodrigues, S Burnham, SR Rainey-Smith, VL Villemagne, A Bush, KA Ellis, CL Masters, D Ames, SL Macaulay, C Szoeke, CC Rowe, RN Martins

Journal article  |  2013  |  Molecular Psychiatry

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A delicate balance: Iron metabolism and diseases of the brain

Dominic Hare, Scott Ayton, Ashley Bush, Peng Lei

Journal article  |  2013  |  Frontiers in Aging Neuroscience

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Increasing Intracellular Bioavailable Copper Selectively Targets Prostate Cancer Cells

Michael A Cater, Helen B Pearson, Kamil Wolyniec, Paul Klaver, Maree Bilandzic, Brett M Paterson, Ashley I Bush, Patrick O Humbert, Sharon La Fontaine, Paul S Donnelly, Ygal Haupt

Journal article  |  2013  |  ACS Chemical Biology

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Deserves a hearing? A case report of remitting tinnitus with N-acetyl cysteine

OM Dean, S Jeavons, GS Malhi, SM Cotton, M Tanious, K Kohlmann, K Hewitt, K Moss, C Allwang, I Schapkaitz, J Robbins, S Dodd, A Bush, M Berk

Journal article  |  2013  |  African Journal of Psychiatry

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A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania

Pedro Vieira da Silva Magalhaes, Olivia M Dean, Ashley I Bush, David L Copolov, Gin S Malhi, Kristy Kohlmann, Susan Jeavons, Ian Schapkaitz, Murray Anderson-Hunt, Michael Berk

Journal article  |  2013  |  Australian & New Zealand Journal of Psychiatry

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PBT434, a novel 8-hydroxyquinazolinone, preserves nigro-striatal circuitry, improves motor performance and inhibits alpha synuclein accumulation in animal models of Parkinson's disease by modulation of iron homeostasis

DI Finkelstein, JL George, PA Adlard, CL Masters, DJ Hare, PA Doble, E Gautier, J Parsons, G Kok, P Huggins, KJ Barnham, AI Bush, RA Cherny

Conference Proceedings  |  2013  |  MOVEMENT DISORDERS

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Three-Month Stability of the CogState Brief Battery in Healthy Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease: Results from the Australian Imaging, Biomarkers, and Lifestyle-Rate of Change Substudy (AIBL-ROCS)

Yen Ying Lim, Judith Jaeger, Karra Harrington, Tim Ashwood, Kathryn A Ellis, Albrecht Stoeffler, Cassandra Szoeke, Rebecca Lachovitzki, Ralph N Martins, Victor L Villemagne, Ashley Bush, Colin L Masters, Christopher C Rowe, David Ames, David Darby, Paul Maruff

Journal article  |  2013  |  Archives of Clinical Neuropsychology

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The effect of dopamine on MPTP-induced rotarod disability

Scott Ayton, Jessica L George, Paul A Adlard, Ashley I Bush, Robert A Cherny, David I Finkelstein

Journal article  |  2013  |  Neuroscience Letters

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Presenilin Promotes Dietary Copper Uptake

Adam Southon, Mark A Greenough, George Ganio, Ashley I Bush, Richard Burke, James Camakaris

Journal article  |  2013  |  PLoS One

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A NOVEL RELATIONSHIP BETWEEN beta-AMYLOID PROTEIN PRECURSOR AND TAU IN ALZHEIMER'S DISEASE RELATED IRON DISRUPTION

James Duce, Peng Lei, Andrew Tsatsanis, Bruce Wong, Linh Lam, Scott Ayton, Jack Rogers, David Finkelstein, Ashley Bush

Conference Proceedings  |  2013  |  AMERICAN JOURNAL OF HEMATOLOGY

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Trafficking of metal ions by proteins implicated in Alzheimer's and Parkinson's diseases

AI Bush

Conference Proceedings  |  2013  |  JOURNAL OF NEUROCHEMISTRY

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Cognitive Consequences of High A beta Amyloid in Mild Cognitive Impairment and Healthy Older Adults: Implications for Early Detection of Alzheimer's Disease

Yen Ying Lim, Kathryn A Ellis, Karra Harrington, Adrian Kamer, Robert H Pietrzak, Ashley I Bush, David Darby, Ralph N Martins, Colin L Masters, Christopher C Rowe, Greg Savage, Cassandra Szoeke, Victor L Villemagne, David Ames, Paul Maruff

Journal article  |  2013  |  Neuropsychology

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Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

Scott Ayton, Peng Lei, James A Duce, Bruce XW Wong, Amelia Sedjahtera, Paul A Adlard, Ashley I Bush, David I Finkelstein

Journal article  |  2013  |  Annals of Neurology

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Metal dyshomeostasis and oxidative stress in Alzheimer's disease

Mark A Greenough, James Camakaris, Ashley I Bush

Journal article  |  2013  |  Neurochemistry International

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Amine oxidase activity of beta-amyloid precursor protein modulates systemic and local catecholamine levels

JA Duce, S Ayton, AA Miller, A Tsatsanis, LQ Lam, L Leone, JE Corbin, H Butzkueven, TJ Kilpatrick, JT Rogers, KJ Barnham, DI Finkelstein, AI Bush

Journal article  |  2013  |  Molecular Psychiatry

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Cognitive Decline in Adults with Amnestic Mild Cognitive Impairment and High Amyloid-beta: Prodromal Alzheimer's Disease?

Yen Ying Lim, Kathryn A Ellis, Karra Harrington, Robert H Pietrzak, Joanne Gale, David Ames, Ashley I Bush, David Darby, Ralph N Martins, Colin L Masters, Christopher C Rowe, Greg Savage, Cassandra Szoeke, Victor L Villemagne, Paul Maruff

Journal article  |  2013  |  Journal of Alzheimer's Disease

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Direct in vivo imaging of essential bioinorganics in Caenorhabditis elegans

Simon A James, Martin D de Jonge, Daryl L Howard, Ashley I Bush, David Paterson, Gawain McColl

Journal article  |  2013  |  Metallomics: integrated biometal science

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Decline in Cognitive Function over 18 Months in Healthy Older Adults with High Amyloid-beta

Kathryn A Ellis, Yen Ying Lim, Karra Harrington, David Ames, Ashley I Bush, David Darby, Ralph N Martins, Colin L Masters, Christopher C Rowe, Greg Savage, Cassandra Szoeke, Victor L Villemagne, Paul Maruff

Journal article  |  2013  |  Journal of Alzheimer's Disease

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Links between copper and cholesterol in Alzheimer's disease

Ya Hui Hung, Ashley I Bush, Sharon La Fontaine

Journal article  |  2013  |  Frontiers in Physiology

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Zinc in Alzheimer's and Parkinson's Diseases

S AYTON, DI Finkelstein, RA Cherny, AI Bush, PA Adlard

Book Chapter  |  2013

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Copper in brain and neurodegeneration

JR Liddell, AI Bush, AR White

Book Chapter  |  2013

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Longitudinal Analysis of Serum Copper and Ceruloplasmin in Alzheimer's Disease

Alan Rembach, James D Doecke, Blaine R Roberts, Andrew D Watt, Noel G Faux, Irene Volitakis, Kelly K Pertile, Rebecca L Rumble, Brett O Trounson, Christopher J Fowler, William Wilson, Kathryn A Ellis, Ralph N Martins, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Ashley I Bush

Journal article  |  2013  |  Journal of Alzheimer's Disease

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The Metal Theory of Alzheimer's Disease

Ashley I Bush

Journal article  |  2013  |  Journal of Alzheimer's Disease

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Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry

Dominic J Hare, Alexandra Grubman, Timothy M Ryan, Amber Lothian, Jeffrey R Liddell, Rudolf Grimm, Toshiaki Matsuda, Philip A Doble, Robert A Cherny, Ashley I Bush, Anthony R White, Colin L Masters, Blaine R Roberts

Journal article  |  2013  |  Metallomics: integrated biometal science

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The Metal Theory of Alzheimer's Disease

Ashley I Bush

Journal article  |  2013  |  Journal of Alzheimer's Disease

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Decreased copper in Alzheimer's disease brain is predominantly in the soluble extractable fraction.

Alan Rembach, Dominic J Hare, Monica Lind, Christopher J Fowler, Robert A Cherny, Catriona McLean, Ashley I Bush, Colin L Masters, Blaine R Roberts

Journal article  |  2013  |  International Journal of Alzheimer's Disease

Alzheimer's disease (AD) is the leading cause of dementia and represents a significant burden on the global economy and society. T..

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Rapid Decline in Episodic Memory in Healthy Older Adults with High Amyloid-beta

Yen Ying Lim, Robert H Pietrzak, Kathryn A Ellis, Judith Jaeger, Karra Harrington, Tim Ashwood, Cassandra Szoeke, Ralph N Martins, Ashley I Bush, Colin L Masters, Christopher C Rowe, Victor L Villemagne, David Ames, David Darby, Paul Maruff

Journal article  |  2013  |  Journal of Alzheimer's Disease

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Copper status in Alzheimer's disease and other neurodegenerative disorders 2013.

Rosanna Squitti, Tjaard Hoogenraad, George Brewer, Ashley I Bush, Renato Polimanti

Journal article  |  2013  |  International Journal of Alzheimer's Disease

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The Role of the Plasma Membrane Redox System in the Pathogenesis of Alzheimer's Disease

Sara M Hancock, David I Finkelstein, Ashley I Bush, Paul A Adlard

Book Chapter  |  2013

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Utility of an improved model of amyloid-beta (A beta(1-42)) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease

Gawain McColl, Blaine R Roberts, Tara L Pukala, Vijaya B Kenche, Christine M Roberts, Christopher D Link, Timothy M Ryan, Colin L Masters, Kevin J Barnham, Ashley I Bush, Robert A Cherny

Journal article  |  2012  |  Molecular Neurodegeneration

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Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease

Yasmina Manso, Javier Carrasco, Gemma Comes, Paul A Adlard, Ashley I Bush, Juan Hidalgo

Journal article  |  2012  |  Cellular and Molecular Life Sciences

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Characterization of the role of metallothionein-3 in an animal model of Alzheimer's disease

Yasmina Manso, Javier Carrasco, Gemma Comes, Gabriele Meloni, Paul A Adlard, Ashley I Bush, Milan Vasak, Juan Hidalgo

Journal article  |  2012  |  Cellular and Molecular Life Sciences

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Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease

James D Doecke, Simon M Laws, Noel G Faux, William Wilson, Samantha C Burnham, Chiou-Peng Lam, Alinda Mondal, Justin Bedo, Ashley I Bush, Belinda Brown, Karl De Ruyck, Kathryn A Ellis, Christopher Fowler, Veer B Gupta, Richard Head, S Lance Macaulay, Kelly Pertile, Christopher C Rowe, Alan Rembach, Mark Rodrigues, et al.

Journal article  |  2012  |  Archives of Neurology

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Effects of N-acetyl cysteine on cognitive function in bipolar disorder

Olivia M Dean, Ashley I Bush, David L Copolov, Kristy Kohlmann, Susan Jeavons, Ian Schapkaitz, Murray Anderson-Hunt, Michael Berk

Journal article  |  2012  |  Psychiatry and Clinical Neurosciences

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Maintenance N-acetyl cysteine treatment for bipolar disorder: A double-blind randomized placebo controlled trial

Michael Berk, Olivia M Dean, Sue M Cotton, Clarissa S Gama, Flavio Kapczinski, Brisa Fernandes, Kristy Kohlmann, Susan Jeavons, Karen Hewitt, Kirsteen Moss, Christine Allwang, Ian Schapkaitz, Heidi Cobb, Ashley I Bush, Seetal Dodd, Gin S Malhi

Journal article  |  2012  |  BMC Medicine

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Alterations in Brain Transition Metals in Huntington Disease An Evolving and Intricate Story

H Diana Rosas, Y Iris Chen, Gheorghe Doros, David H Salat, Nan-kuei Chen, Ken K Kwong, Ashley Bush, Jonathan Fox, Steven M Hersch

Journal article  |  2012  |  Archives of Neurology

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Translating the Rosetta Stone of N-Acetylcysteine

Olivia M Dean, Ashley I Bush, Michael Berk

Journal article  |  2012  |  Biological Psychiatry

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P2X7 Receptor-mediated Scavenger Activity of Mononuclear Phagocytes toward Non-opsonized Particles and Apoptotic Cells Is Inhibited by Serum Glycoproteins but Remains Active in Cerebrospinal Fluid

Ben J Gu, James A Duce, Valentina A Valova, Bruce Wong, Ashley I Bush, Steven Petrou, James S Wiley

Journal article  |  2012  |  Journal of Biological Chemistry

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Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues

Hongyun Li, Genevieve Evin, Andrew F Hill, Ya Hui Hung, Ashley I Bush, Brett Garner

Journal article  |  2012  |  Clinical Science

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Systemic illness moderates the impact of N-acetyl cysteine in bipolar disorder

PV Magalhaes, OM Dean, AI Bush, DL Copolov, D Weisinger, GS Malhi, K Kohlmann, S Jeavons, I Schapkaitz, M Anderson-Hunt, M Berk

Journal article  |  2012  |  Progress in Neuro-Psychopharmacology and Biological Psychiatry

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The hypoxia imaging agent Cu-II(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

Lin W Hung, Victor L Villemagne, Lesley Cheng, Nicki A Sherratt, Scott Ayton, Anthony R White, Peter J Crouch, SinChun Lim, Su Ling Leong, Simon Wilkins, Jessica George, Blaine R Roberts, Chi LL Pham, Xiang Liu, Francis CK Chiu, David M Shackleford, Andrew K Powell, Colin L Masters, Ashley I Bush, Graeme O'Keefe, et al.

Journal article  |  2012  |  Journal of Experimental Medicine

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Metal chaperones: a holistic approach to the treatment of Alzheimer's disease.

Paul Anthony Adlard, Ashley Ian Bush

Journal article  |  2012  |  Frontiers in Psychiatry

As evidence for the role of metal ion dysregulation in the pathogenesis of multiple CNS disorders grows, it has become important t..

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Caenorhabditis elegans Maintains Highly Compartmentalized Cellular Distribution of Metals and Steep Concentration Gradients of Manganese

Gawain McColl, Simon A James, Sheridan Mayo, Daryl L Howard, Christopher G Ryan, Robin Kirkham, Gareth F Moorhead, David Paterson, Martin D de Jonge, Ashley I Bush

Journal article  |  2012  |  PLoS One

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Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

Peng Lei, Scott Ayton, David I Finkelstein, Loredana Spoerri, Giuseppe D Ciccotosto, David K Wright, Bruce XW Wong, Paul A Adlard, Robert A Cherny, Linh Q Lam, Blaine R Roberts, Irene Volitakis, Gary F Egan, Catriona A McLean, Roberto Cappai, James A Duce, Ashley I Bush

Journal article  |  2012  |  Nature Medicine

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Predictors of rapid cognitive decline in Alzheimer's disease: results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing

Alessandro Sona, Ping Zhang, David Ames, Ashley I Bush, Nicola T Lautenschlager, Ralph N Martins, Colin L Masters, Christopher C Rowe, Cassandra Szoeke, Kevin Taddei, Kathryn A Ellis

Journal article  |  2012  |  International Psychogeriatrics

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Identification of Biomarkers During Investigational Therapy for Niemann-Pick Type C Disease

David Killilea, Jung Suh, Niklas Mattson, Henrik Zetterberg, Erik Portelius, Kaj Blennow, Ya Hui Hung, Ashley Bush, Caroline Hastings

Conference Proceedings  |  2012  |  Molecular Genetics and Metabolism

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Elevated labile Cu is associated with oxidative pathology in Alzheimer disease

Simon A James, Irene Volitakis, Paul A Adlard, James A Duce, Colin L Masters, Robert A Cherny, Ashley I Bush

Journal article  |  2012  |  Free Radical Biology and Medicine

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Rapid Generation of Dityrosine Cross-linked A beta Oligomers via Cu-Redox Cycling

Adam P Gunn, Blaine R Roberts, Ashley I Bush

Journal article  |  2012  |  Methods in Molecular Biology

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Copper and Alzheimer disease: The good, the bad and the ugly

YH Hung, AI Bush, RA Cherny

Book Chapter  |  2012

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The role of metallobiology and amyloid-ss peptides in Alzheimer's disease

Blaine R Roberts, Timothy M Ryan, Ashley I Bush, Colin L Masters, James A Duce

Journal article  |  2012  |  Journal of Neurochemistry

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Metal chaperones: a holistic approach to the treatment of Alzheimer's disease

PA Adlard, AI Bush

Journal article  |  2012  |  Frontiers in Psychiatry

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PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease.

Robert A Cherny, Scott Ayton, David I Finkelstein, Ashley I Bush, Gawain McColl, Stephen M Massa

Journal article  |  2012  |  Journal of Huntington's Disease

BACKGROUND: There is evidence that interaction with biologically important metals, particularly copper and iron, contributes to th..

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The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: An open label trial

Michael Berk, Olivia Dean, Sue M Cotton, Clarissa S Gama, Flavio Kapczinski, Brisa S Fernandes, Kristy Kohlmann, Susan Jeavons, Karen Hewitt, Christine Allwang, Heidi Cobb, Ashley I Bush, Ian Schapkaitz, Seetal Dodd, Gin S Malhi

Journal article  |  2011  |  Journal of Affective Disorders

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N-acetylcysteine for major depressive episodes in bipolar disorder

Pedro V Magalhaes, Olivia M Dean, Ashley I Bush, David L Copolov, Gin S Malhi, Kristy Kohlmann, Susan Jeavons, Ian Schapkaitz, Murray Anderson-Hunt, Michael Berk

Journal article  |  2011  |  Revista Brasileira de Psiquiatria

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Who's left? Symptoms of schizophrenia that predict clinical trial dropout

Jason Thompson, Michael Berk, Olivia Dean, Kristy Kohlmann, Sue Jeavons, Ashley Bush, David Copolov

Journal article  |  2011  |  Human Psychopharmacology - Clinical and Experimental

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The Neurophysiology and Pathology of Brain Zinc

Stefano L Sensi, Pierre Paoletti, Jae-Young Koh, Elias Aizenman, Ashley I Bush, Michal Hershfinkel

Journal article  |  2011  |  Journal of Neuroscience

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The Alzheimer's therapeutic PBT2 promotes amyloid-beta degradation and GSK3 phosphorylation via a metal chaperone activity

Peter J Crouch, Maria S Savva, Lin W Hung, Paul S Donnelly, Alexandra I Mot, Sarah J Parker, Mark A Greenough, Irene Volitakis, Paul A Adlard, Robert A Cherny, Colin L Masters, Ashley I Bush, Kevin J Barnham, Anthony R White

Journal article  |  2011  |  Journal of Neurochemistry

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Role of amyloid-β-metal interactions in Alzheimers disease

JA Duce, AI Bush, PA Adlard

Journal article  |  2011  |  Future Neurology

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N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and D-amphetamine-treated rats: Relevance to schizophrenia and bipolar disorder

Olivia M Dean, Maarten van den Buuse, Michael Berk, David L Copolov, Christine Mavros, Ashley I Bush

Journal article  |  2011  |  Neuroscience Letters

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Qualitative Methods in Early-Phase Drug Trials: Broadening the Scope of Data and Methods From an RCT of N-Acetylcysteine in Schizophrenia

Michael Berk, Ahmed Munib, Olivia Dean, Gin S Malhi, Kristy Kohlmann, Ian Schapkaitz, Sue Jeavons, Fiona Katz, Murray Anderson-Hunt, Philippe Conus, Barbara Hanna, Renee Otmar, Felicity Ng, David L Copolov, Ashley I Bush

Journal article  |  2011  |  Journal of Clinical Psychiatry

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N acetyl cysteine for major depressive episodes in bipolar disorder

PV Magalhaes, OM Dean, AI Bush, DL Copolov, D Weisinger, GS Malhi, K Kohlmann, S Jeavons, I Schapkaitz, M Anderson-Hunt, M Berk

Conference Proceedings  |  2011  |  BIPOLAR DISORDERS

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N-acetyl cysteine (NAC) as an adjunctive therapy for bipolar depression

O Dean, M Berk, SM Cotton, AI Bush, CS Gama, F Kapczinski, B Fernandez, K Kohlmann, S Jeavons, K Hewitt, K Moss, C Allwang, S Dodd, H Cobb, I Schapkaitz, GS Malhi

Conference Proceedings  |  2011  |  BIPOLAR DISORDERS

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Cysteine Oxidation within N-terminal Mutant Huntingtin Promotes Oligomerization and Delays Clearance of Soluble Protein

Jonathan H Fox, Teal Connor, Megan Stiles, Jibrin Kama, Zhen Lu, Kathryn Dorsey, Gregory Liebermann, Ellen Sapp, Robert A Cherny, Mary Banks, Irene Volitakis, Marian DiFiglia, Oksana Berezovska, Ashley I Bush, Steven M Hersch

Journal article  |  2011  |  Journal of Biological Chemistry

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Dimensions of improvement in a clinical trial of N-acetyl cysteine for bipolar disorder

Pedro V Magalhaes, Olivia M Dean, Ashley I Bush, David L Copolov, Gin S Malhi, Kristy Kohlmann, Susan Jeavons, Ian Schapkaitz, Murray Anderson-Hunt, Michael Berk

Journal article  |  2011  |  Acta Neuropsychiatrica

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Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity

Mark A Greenough, Irene Volitakis, Qiao-Xin Li, Katrina Laughton, Genevieve Evin, Michael Ho, Andrew H Dalziel, James Camakaris, Ashley I Bush

Journal article  |  2011  |  Journal of Biological Chemistry

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Copper Promotes the Trafficking of the Amyloid Precursor Protein

Karla M Acevedo, Ya Hui Hung, Andrew H Dalziel, Qiao-Xin Li, Katrina Laughton, Krutika Wikhe, Alan Rembach, Blaine Roberts, Colin L Masters, Ashley I Bush, James Camakaris

Journal article  |  2011  |  Journal of Biological Chemistry

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Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

Paul A Adlard, Laura Bica, Anthony R White, Milawaty Nurjono, Gulay Filiz, Peter J Crouch, Paul S Donnelly, Roberto Cappai, David I Finkelstein, Ashley I Bush

Journal article  |  2011  |  PLoS One

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N-acetyl cysteine add-on treatment for bipolar II disorder: a subgroup analysis of a randomized placebo-controlled trial

PV Magalhaes, OM Dean, AI Bush, DL Copolov, GS Malhi, K Kohlmann, S Jeavons, I Schapkaitz, M Anderson-Hunt, M Berk

Journal article  |  2011  |  Journal of Affective Disorders

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Plasma apolipoprotein E and Alzheimer disease risk The AIBL study of aging

VB Gupta, SM Laws, VL Villemagne, D Ames, AI Bush, KA Ellis, JK Lui, C Masters, CC Rowe, C Szoeke, K Taddei, RN Martins

Journal article  |  2011  |  Neurology

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The plasma membrane redox system in Alzheimer's disease

PA Adlard, AI Bush

Journal article  |  2011  |  Experimental Neurology

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Biological Metals: Metallostasis and Alzheimer's Disease

A Rembach, JA Duce, LA O'Sullivan, RE Tanzi, AI Bush

Book Chapter  |  2011  |  RSC Drug Discovery Series

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A copper binding site within the pathological conformer epitope of mutant SOD1

Ashley I Bush

Journal article  |  2011  |  Frontiers in Neuroscience

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Zinc and Alzheimer's Disease

Paul A Adlard, Ashley I Bush

Book Chapter  |  2011  |  Biomedical and Health Research- Commission of the European Communities then IOS Press

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Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study

Noel G Faux, Kathryn A Ellis, Lorine Porter, Chris J Fowler, Simon M Laws, Ralph N Martins, Kelly K Pertile, Alan Rembach, Chris C Rowe, Rebecca L Rumble, Cassandra Szoeke, Kevin Taddei, Tania Taddei, Brett O Trounson, Victor L Villemagne, Vanessa Ward, David Ames, Colin L Masters, Ashley I Bush

Journal article  |  2011  |  Journal of Alzheimer's Disease

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Effects of Anticholinergic Drugs on Cognitive Function in Older Australians: Results from the AIBL Study

Gobhathai Sittironnarit, David Ames, Ashley I Bush, Noel Faux, Leon Flicker, Jonathan Foster, Sarah Hilmer, Nicola T Lautenschlager, Paul Maruff, Colin L Masters, Ralph N Martins, Christopher Rowe, Cassandra Szoeke, Kathryn A Ellis

Journal article  |  2011  |  Dementia and Geriatric Cognitive Disorders

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GSK-3 in Neurodegenerative Diseases.

Peng Lei, Scott Ayton, Ashley I Bush, Paul A Adlard

Journal article  |  2011  |  International Journal of Alzheimer's Disease

Glycogen synthase kinase-3 (GSK-3) regulates multiple cellular processes, and its dysregulation is implicated in the pathogenesis ..

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Disturbed copper bioavailability in Alzheimer's disease.

Daniela Kaden, Ashley I Bush, Ruth Danzeisen, Thomas A Bayer, Gerd Multhaup

Journal article  |  2011  |  International Journal of Alzheimer's Disease

Recent data from in vitro, animal, and human studies have shed new light on the positive roles of copper in many aspects of AD. Co..

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Copper modulation as a therapy for Alzheimer's disease?

Yasmina Manso, Gemma Comes, Juan Hidalgo, Ashley I Bush, Paul A Adlard

Journal article  |  2011  |  International Journal of Alzheimer's Disease

The role of metals in the pathophysiology of Alzheimer's disease (AD) has gained considerable support in recent years, with both i..

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Syntaxin 5 Is Required for Copper Homeostasis in Drosophila and Mammals

Melanie Norgate, Adam Southon, Mark Greenough, Michael Cater, Ashley Farlow, Philip Batterham, Ashley I Bush, V Nathan Subramaniam, Richard Burke, James Camakaris

Journal article  |  2010  |  PLoS One

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Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats

Kwok Ho Christopher Choy, Olivia Dean, Michael Berk, Ashley I Bush, Maarten van den Buuse

Journal article  |  2010  |  European Journal of Pharmacology

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Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain

Joo-Yong Lee, Eunsil Cho, Tae-Youn Kim, Dong-Kyu Kim, Richard D Palmiter, Irene Volitakis, Jong S Kim, Ashley I Bush, Jae-Young Koh

Journal article  |  2010  |  BioMetals

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Interaction of glutathione depletion and psychotropic drug treatment in prepulse inhibition in rats and mice

Olivia Dean, Ashley I Bush, Michael Berk, David L Copolov, Maarten van den Buuse

Journal article  |  2010  |  Pharmacology, Biochemistry and Behavior

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Tau protein: Relevance to Parkinson's disease

Peng Lei, Scott Ayton, David I Finkelstein, Paul A Adlard, Colin L Masters, Ashley I Bush

Journal article  |  2010  |  International Journal of Biochemistry and Cell Biology

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Iron-Export Ferroxidase Activity of beta-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

James A Duce, Andrew Tsatsanis, Michael A Cater, Simon A James, Elysia Robb, Krutika Wikhe, Su Ling Leong, Keyla Perez, Timothy Johanssen, Mark A Greenough, Hyun-Hee Cho, Denise Galatis, Robert D Moir, Colin L Masters, Catriona McLean, Rudolph E Tanzi, Roberto Cappai, Kevin J Barnham, Giuseppe D Ciccotosto, Jack T Rogers, et al.

Journal article  |  2010  |  Cell

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Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans

Gawain McColl, Aric N Rogers, Silvestre Alavez, Alan E Hubbard, Simon Melov, Christopher D Link, Ashley I Bush, Pankaj Kapahi, Gordon J Lithgow

Journal article  |  2010  |  Cell Metabolism

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Altered microglial copper homeostasis in a mouse model of Alzheimer's disease

Zhiqiang Zheng, Carine White, Jaekwon Lee, Troy S Peterson, Ashley I Bush, Grace Y Sun, Gary A Weisman, Michael J Petris

Journal article  |  2010  |  Journal of Neurochemistry

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Biological metals and Alzheimer's disease: Implications for therapeutics and diagnostics

James A Duce, Ashley I Bush

Journal article  |  2010  |  Progress in Neurobiology

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Role of Metals in Alzheimer Disease

BR Roberts, AI Bush

Journal article  |  2010

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Generation of soluble oligomeric beta-amyloid species via copper catalyzed oxidation with implications for Alzheimer's disease: A DFT study

Fredrik Haeffner, Kevin J Barnham, Ashley I Bush, Tore Brinck

Journal article  |  2010  |  Journal of Molecular Modeling

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A domain level interaction network of amyloid precursor protein and A beta of Alzheimer's disease

Victoria M Perreau, Sandra Orchard, Paul A Adlard, Shayne A Bellingham, Roberto Cappai, Giuseppe D Ciccotosto, Tiffany F Cowie, Peter J Crouch, James A Duce, Genevieve Evin, Noel G Faux, Andrew F Hill, Ya Hui Hung, Simon A James, Qiao-Xin Li, Su San Mok, Deborah J Tew, Anthony R White, Ashley I Bush, Henning Hermjakob, et al.

Journal article  |  2010  |  Proteomics

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Behavioural phenotype of APPC100.V717F transgenic mice over-expressing a mutant A beta-bearing fragment is associated with reduced NMDA receptor density

Wah Chin Boon, Maarten van den Buuse, Nico Wegener, Sally Martin, Hui Kheng Chua, Ashley I Bush, Colin L Masters, Paul A Adlard, Qiao-Xin Li

Journal article  |  2010  |  Behavioural Brain Research

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Monomerized Cu,Zn-superoxide dismutase induces oxidative stress through aberrant Cu binding

Hitoshi Kishigami, Seiichi Nagano, Ashley I Bush, Saburo Sakoda

Journal article  |  2010  |  Free Radical Biology and Medicine

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Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

Paul A Adlard, Jacqui M Parncutt, David I Finkelstein, Ashley I Bush

Journal article  |  2010  |  Journal of Neuroscience

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Serum zinc is decreased in Alzheimer's disease and serum arsenic correlates positively with cognitive ability

Larry Baum, Iris Hiu Shuen Chan, Stanley Kwok-Kuen Cheung, William B Goggins, Vincent Mok, Linda Lam, Vivian Leung, Elsie Hui, Chelsia Ng, Jean Woo, Helen Fung Kum Chiu, Benny Chung-Ying Zee, William Cheng, Ming-Houng Chan, Samuel Szeto, Victor Lui, Joshua Tsoh, Ashley I Bush, Christopher Wai Kei Lam, Timothy Kwok

Journal article  |  2010  |  Biometals

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Calcium is not all

Ashley I Bush

Journal article  |  2010  |  Neuron

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Glutathione and redox biology in Bipolar Disorder; from pathophysiology to novel treatments

M Berk, O Dean, K Hewitt, A Bush, F Kapczinski, S Jeavons, C Gama, G Malhi, D Copolov, H Cobb, B Fernandes

Conference Proceedings  |  2010  |  INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

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Plasma Amyloid-beta as a Biomarker in Alzheimer's Disease: The AIBL Study of Aging

James K Lui, Simon M Laws, Qiao-Xin Li, Victor L Villemagne, David Ames, Belinda Brown, Ashley I Bush, Karl De Ruyck, Jasmin Dromey, Kathryn A Ellis, Noel G Faux, Jonathan Foster, Christopher Fowler, Veer Gupta, Peter Hudson, Katrina Laughton, Colin L Masters, Kelly Pertile, Alan Rembach, Mira Rimajova, et al.

Journal article  |  2010  |  Journal of Alzheimer's Disease

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PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

Noel G Faux, Craig W Ritchie, Adam Gunn, Alan Rembach, Andrew Tsatsanis, Justin Bedo, John Harrison, Lars Lannfelt, Kaj Blennow, Henrik Zetterberg, Martin Ingelsson, Colin L Masters, Rudolph E Tanzi, Jeffrey L Cummings, Caroline M Herd, Ashley I Bush

Journal article  |  2010  |  Journal of Alzheimer's Disease

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Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain

Dominic J Hare, Jessica L George, Rudolph Grimm, Simon Wilkins, Paul A Adlard, Robert A Cherny, Ashley I Bush, David I Finkelstein, Philip Doble

Journal article  |  2010  |  Metallomics: integrated biometal science

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Copper in the brain and Alzheimer's disease

Ya Hui Hung, Ashley I Bush, Robert Alan Cherny

Journal article  |  2010  |  Journal of Biological Inorganic Chemistry

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Effects of N-acetylcysteine on substance use in bipolar disorder: A randomised placebo-controlled clinical trial

Michelle Bernardo, Seetal Dodd, Clarissa S Gama, David L Copolov, Olivia Dean, Kristy Kohlmann, Susan Jeavons, Ian Schapkaitz, Murray Anderson-Hunt, Ashley I Bush, Michael Berk

Journal article  |  2009  |  Acta Neuropsychiatrica

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Zinc in the physiology and pathology of the CNS

Stefano L Sensi, Pierre Paoletti, Ashley I Bush, Israel Sekler

Journal article  |  2009  |  Nature Reviews Neuroscience

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Biomarkers for Alzheimer's disease from large cohort studies

A Milner, KA Ellis, AI Bush, CL Masters, D De Fazio, J Foster, P Hudson, NT Lautenschlager, N Lenzo, RN Martins, K Pike, CC Rowe, G Savage, C Szoeke, K Taddei, VL Villemagne, M Woodward, D Darby, D Ames

Conference Proceedings  |  2009  |  Journal of the Neurological Sciences

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Effects of N-acetylcysteine on substance use in bipolar disorder: a randomised placebo-controlled clinical trial

Michelle Bernardo, Seetal Dodd, Clarissa S Gama, David L Copolov, Olivia Dean, Kristy Kohlmann, Susan Jeavons, Ian Schapkaitz, Murray Anderson-Hunt, Ashley I Bush, Michael Berk

Journal article  |  2009  |  Acta Neuropsychiatrica

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THE ROLE OF COPPER AND ZINC IN REGULATING THE PROCESSING AND TRAFFICKING OF THE AMYLOID PRECURSOR PROTEIN

KM Acevedo, AH Dalziel, QX Li, K Laughton, YH Hung, K Wikhe, CL Masters, A Bush, J Camakaris

Conference Proceedings  |  2009  |  JOURNAL OF NEUROCHEMISTRY

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MODULATING COPPER BIO-AVAILABILITY TO TREAT NEURODEGENERATIVE DISEASES

PJ Crouch, LW Hung, CP Soon, PA Adlard, A Bush, CL Masters, QX Li, PS Donnelly, KJ Barnham, AR White

Conference Proceedings  |  2009  |  JOURNAL OF NEUROCHEMISTRY

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The Caenorhabditis elegans A beta(1-42) Model of Alzheimer Disease Predominantly Expresses A beta(3-42)

Gawain Mccoll, Blaine R Roberts, Adam P Gunn, Keyla A Perez, Deborah J Tew, Colin L Masters, Kevin J Barnham, Robert A Cherny, Ashley I Bush

Journal article  |  2009  |  Biological Chemistry

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Paradoxical Condensation of Copper with Elevated beta-Amyloid in Lipid Rafts under Cellular Copper Deficiency Conditions IMPLICATIONS FOR ALZHEIMER DISEASE

Ya Hui Hung, Elysia L Robb, Irene Volitakis, Michael Ho, Genevieve Evin, Qiao-Xin Li, Janetta G Culvenor, Colin L Masters, Robert A Cherny, Ashley I Bush

Journal article  |  2009  |  Journal of Biological Chemistry

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The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease

Kathryn A Ellis, Ashley I Bush, David Darby, Daniela De Fazio, Jonathan Foster, Peter Hudson, Nicola I Lautenschlager, Nat Lenzo, Ralph N Martins, Paul Maruff, Colin Masters, Andrew Milner, Kerryn Pike, Christopher Rowe, Greg Savage, Cassandra Szoeke, Kevin Taddei, Victor Villemagne, Michael Woodward, David Ames

Journal article  |  2009  |  International Psychogeriatrics

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A Role for Glutathione in the Pathophysiology of Bipolar Disorder and Schizophrenia? Animal Models and Relevance to Clinical Practice

OM Dean, M van den Buuse, AI Bush, DL Copolov, F Ng, S Dodd, M Berk

Journal article  |  2009  |  Current Medicinal Chemistry

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Zinc and copper modulate Alzheimer A beta levels in human cerebrospinal fluid

Dorothea Strozyk, Lenore J Launer, Paul A Adlard, Robert A Cherny, Andrew Tsatsanis, Irene Volitakis, Kai Blennow, Helen Petrovitch, Lon R White, Ashley I Bush

Journal article  |  2009  |  Neurobiology of Aging

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Chronic Exposure to High Levels of Zinc or Copper has Little Effect on Brain Metal Homeostasis or A beta Accumulation in Transgenic APP-C100 Mice

Christa J Maynard, Roberto Cappai, Irene Volitakis, Katrina M Laughton, Colin L Masters, Ashley I Bush, Qiao-Xin Li

Journal article  |  2009  |  Cellular & Molecular Neurobiology

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SLC30A3 Responds to Glucose- and Zinc Variations in beta-Cells and Is Critical for Insulin Production and In Vivo Glucose-Metabolism During beta-Cell Stress

Kamille Smidt, Niels Jessen, Andreas Bronden Petersen, Agnete Larsen, Nils Magnusson, Johanne Bruun Jeppesen, Meredin Stoltenberg, Janetta G Culvenor, Andrew Tsatsanis, Birgitte Brock, Ole Schmitz, Lise Wogensen, Ashley I Bush, Jorgen Rungby

Journal article  |  2009  |  PLoS One

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Copper transport into the secretory pathway is regulated by oxygen in macrophages

Carine White, Taiho Kambe, Yan G Fulcher, Sherri W Sachdev, Ashley I Bush, Kevin Fritsche, Jaekwon Lee, Thomas P Quinn, Michael J Petris

Journal article  |  2009  |  Journal of Cell Science

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beta-AMYLOID AS A MOLECULAR THERAPEUTIC TARGET IN ALZHEIMER'S DISEASE

Paul A Adlard, Simon A James, Ashley I Bush, Colin L Masters

Journal article  |  2009  |  Drugs of today (Barcelona, Spain : 1998)

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Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme

Giuseppe Grasso, Ashley I Bush, Roberta D'Agata, Enrico Rizzarelli, Giuseppe Spoto

Journal article  |  2009  |  European Biophysics Journal

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Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice

Olivia Dean, Ashley I Bush, Michael Berk, David L Copolov, Maarten van den Buuse

Journal article  |  2009  |  Behavioural Brain Research

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Targeting the Progression of Parkinson's Disease

JL George, S Mok, D Moses, S Wilkins, AI Bush, RA Cherny, DI Finkelstein

Journal article  |  2009  |  Current Neuropharmacology

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Increasing Cu bioavailability inhibits A beta oligomers and tau phosphorylation

Peter J Crouch, Lin Wai Hung, Paul A Adlard, Mikhalina Cortes, Varsha Lal, Gulay Filiz, Keyla A Perez, Milawaty Nurjono, Aphrodite Caragounis, Tai Du, Katrina Laughton, Irene Volitakis, Ashley I Bush, Qiao-Xin Li, Colin L Masters, Roberto Cappai, Robert A Cherny, Paul S Donnelly, Anthony R White, Kevin J Barnham

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

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Intracellular amyloid formation in muscle cells of A beta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

Alicia N Minniti, Daniela L Rebolledo, Paula M Grez, Ricardo Fadic, Rebeca Aldunate, Irene Volitakis, Robert A Cherny, Carlos Opazo, Colin Masters, Ashley I Bush, Nibaldo C Inestrosa

Journal article  |  2009  |  Molecular Neurodegeneration

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Quantitative elemental bio-imaging of Mn, Fe, Cu and Zn in 6-hydroxydopamine induced Parkinsonism mouse models

Dominic Hare, Brian Reedy, Rudolf Grimm, Simon Wilkins, Irene Volitakis, Jessica L George, Robert A Cherny, Ashley I Bush, David I Finkelstein, Philip Doble

Journal article  |  2009  |  Metallomics: integrated biometal science

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Therapeutics of Alzheimer’s disease based on metal bioavailability

SS Mok, AI Bush

Book Chapter  |  2009

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ß-amyloid as a molecular therapeutic target in Alzheimer's disease

P ADLARD, S JAMES, A BUSH, C MASTERS

Journal article  |  2009  |  Drugs of Today

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Clioquinol Protects Against Cell Death in Parkinson's Disease Models In Vivo and In Vitro

Simon Wilkins, Colin L Masters, Ashley I Bush, Robert A Cherny, David I Finkelstein

Conference Proceedings  |  2009  |  BASAL GANGLIA IX

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Pharmacotherapeutic targets in Alzheimer's disease

Yif'at Biran, Colin L Masters, Kevin J Barnham, Ashley I Bush, Paul A Adlard

Journal article  |  2009  |  Journal of Cellular and Molecular Medicine

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Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease

Jack T Rogers, Ashley I Bush, Hyan-Hee Cho, Deborah H Smith, Andrew M Thomson, Avi L Friedlich, Deboni K Lahiri, Peter J Leedman, Xudong Huang, Catherine M Cahill

Journal article  |  2008  |  Biochemical Society Transactions

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Sequestration of Copper from beta-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents

Wei-hui Wu, Peng Lei, Qian Liu, Jia Hu, Adam P Gunn, Mei-sha Chen, Yan-fang Rui, Xiao-yang Su, Zuo-ping Xie, Yu-Fen Zhao, Ashley I Bush, Yan-mei Li

Journal article  |  2008  |  Journal of Biological Chemistry

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N-acetyl cysteine for depressive symptoms in bipolar disorder - A double-blind randomized placebo-controlled trial

Michael Berk, David L Copolov, Olivia Dean, Kristy Lu, Sue Jeavons, Ian Schapkaitz, Murray Anderson-Hunt, Ashley I Bush

Journal article  |  2008  |  Biological Psychiatry

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Safety, efficacy, and biomarker findings of PBT2 in targeting A beta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

Lars Lannfelt, Kaj Blennow, Henrik Zetterberg, Stellan Batsman, David Ames, John Hrrison, Colin L Masters, Steve Targum, Ashley I Bush, Ross Murdoch, Janet Wilson, Craig W Ritchie

Journal article  |  2008  |  Lancet Neurology

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Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Felicity Ng, Michael Berk, Olivia Dean, Ashley I Bush

Journal article  |  2008  |  International Journal of Neuropsychopharmacology

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N-acetyl cysteine as a glutathione precursor for schizophrenia - A double-blind, randomized, placebo-controlled trial

Michael Berk, David Copolov, Olivia Dean, Kristy Lu, Sue Jeavons, Ian Schapkaitz, Murray Anderson-Hunt, Fiona Judd, Fiona Katz, Paul Katz, Sean Ording-Jespersen, John Little, Philippe Conus, Michel Cuenod, Kim Q Do, Ashley I Bush

Journal article  |  2008  |  Biological Psychiatry

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Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients

Suzie Lavoie, Micah M Murray, Patricia Deppen, Maria G Knyazeva, Michael Berk, Olivier Boulat, Pierre Bovet, Ashley I Bush, Philippe Conus, David Copolov, Eleonora Fornari, Reto Meuli, Alessandra Solida, Pascal Vianin, Michel Cuenod, Thierry Buclin, Kim Q Do

Journal article  |  2008  |  Neuropsychopharmacology

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial A beta

Paul A Adlard, Robert A Cherny, David I Finkelstein, Elisabeth Gautier, Elysia Robb, Mikhalina Cortes, Irene Volitakis, Xiang Liu, Jeffrey P Smith, Keyla Perez, Katrina Laughton, Qiao-Xin Li, Susan A Charman, Joseph A Nicolazzo, Simon Wilkins, Karolina Deleva, Toni Lynch, Gaik Kok, Craig W Ritchie, Rudolph E Tanzi, et al.

Journal article  |  2008  |  Neuron

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Therapeutics for Alzheimer's disease based on the Metal Hypothesis

Ashley I Bush, Rudolph E Tanzi

Journal article  |  2008  |  Neurotherapeutics

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Glutathione: a novel treatment target in psychiatry

Michael Berk, Felicity Ng, Olivia Dean, Seetal Dodd, Ashley I Bush

Journal article  |  2008  |  Trends in Pharmacological Sciences

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Intracellular copper deficiency increases amyloid-ss secretion by diverse mechanisms

Michael A Cater, Kelly T McInnes, Qiao-Xin Li, Irene Volitakis, Sharon La Fontaine, Julian FB Mercer, Ashley I Bush

Journal article  |  2008  |  Biochemical Journal

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Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease

Kevin J Barnham, Vijaya B Kenche, Giuseppe D Ciccotosto, David P Smith, Deborah J Tew, Xiang Liu, Keyla Perez, Greg A Cranston, Timothy J Johanssen, Irene Volitakis, Ashley I Bush, Colin L Masters, Anthony R White, Jeffrey P Smith, Robert A Cherny, Roberto Cappai

Journal article  |  2008  |  Proceedings of the National Academy of Sciences of the United States of America

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Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays

Tai Du, Sharon L La Fontaine, Michael Abdo, Shayne A Bellingham, Mark Greenough, Irene Volitakis, Robert A Cherny, Ashley I Bush, Peter J Hudson, James Camakaris, Julian F Mercer, Peter J Crouch, Colin L Masters, Victoria M Perreau, Anthony R White

Journal article  |  2008  |  Proteomics - Clinical Applications

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INOR 408-Zinc and copper in Alzheimer's disease

Ashley I Bush

Conference Proceedings  |  2008  |  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

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Metals in Alzheimer's and Parkinson's diseases

Kevin J Barnham, Ashley I Bush

Journal article  |  2008  |  Current Opinion in Chemical Biology

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Twenty years of metallo-neurobiology: where to now?

Ashley I Bush, Cyril C Curtain

Journal article  |  2008  |  European Biophysics Journal

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Insights into Zn2 homeostasis in neurons from experimental and modeling studies

Robert A Colvin, Ashley I Bush, Irene Volitakis, Charles P Fontaine, Dustin Thomas, Kazuya Kikuchi, William R Holmes

Journal article  |  2008  |  American Journal of Physiology - Cell Physiology

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Sensitive, selective, and irreversible inhibition of cyclooxygenase-2 activity by copper

Seiichi Nagano, Ashley I Bush

Journal article  |  2008  |  ChemMedChem

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Metal Complexing Agents for the Treatment of Alzheimer's Disease

Anthony R White, Ashley I Bush

Book Chapter  |  2008  |  Topics in Medicinal Chemistry

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Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease

Peter J Crouch, Susan-Marie E Harding, Anthony R White, James Camakaris, Ashley I Bush, Colin L Masters

Journal article  |  2008  |  International Journal of Biochemistry and Cell Biology

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Drug Development Based on the Metals Hypothesis of Alzheimer's Disease

Ashley I Bush

Journal article  |  2008  |  Journal of Alzheimer's Disease

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Metals, Amyloid and Oxidative Stress in Alzheimer's Disease

AI Bush, SS Mok

Conference Proceedings  |  2008  |  PROCEEDINGS OF THE XIV BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL

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Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency

M Stoltenberg, AI Bush, G Bach, K Smidt, A Larsen, J Rungby, S Lund, P Doering, G Danscher

Journal article  |  2007  |  Neuroscience

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Metal ions and Alzheimer's disease

PA Adlard, AI Bush

Book Chapter  |  2007

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Aβ structure and aggregation

C Glabe, AI Bush

Book Chapter  |  2007

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Glutathione depletion in animal models of psychiatric disorders

Olivia M Dean, Ashley I Bush, Maarten van den Buuse, David L Copolov, Michael Berk

Conference Proceedings  |  2007  |  BIPOLAR DISORDERS

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Mitochondria in aging and Alzheimer's disease

PJ Crouch, K Cimdins, JA Duce, AI Bush, IA Trounce

Journal article  |  2007  |  Rejuvenation Research

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The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease

Peter J Crouch, Anthony R White, Ashley I Bush

Journal article  |  2007  |  FEBS Journal

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Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau

Simon Melov, Paul A Adlard, Karl Morten, Felicity Johnson, Tamara R Golden, Doug Hinerfeld, Birgit Schilling, Christine Mavros, Colin L Masters, Irene Volitakis, Qiao-Xin Li, Katrina Laughton, Alan Hubbard, Robert A Cherny, Brad Gibson, Ashley I Bush

Journal article  |  2007  |  PLoS One

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Antioxidant treatment of the glutathione deficiency in bipolar disorder with n-acetyl cysteine: a double blind randomized placebo controlled trial

M Berk, DL Copolov, O Dean, K Lu, S Jeavons, I Schapkaitz, MA Hunt, AI Bush

Conference Proceedings  |  2007  |  BIPOLAR DISORDERS

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Metallothionein-I overexpression rescues partly the phenotype of the APP2576 mouse model of Alzheimer disease

J Hidalgo, M Giralt, J Carrasco, J Manso, S Florit, A Quintana, A Molinero, M Penkowa, JC Lopez, JM Delgado, PA Adlard, AI Bush

Conference Proceedings  |  2007  |  JOURNAL OF NEUROCHEMISTRY

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Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis

Shohei Watanabe, Seiichi Nagano, James Duce, Mahmoud Kiaei, Qiao-Xin Li, Stephanie M Tucker, Ashutosh Tiwari, Robert H Brown, M Flint Beal, Lawrence J Hayward, Valeria C Culotta, Satoshi Yoshihara, Saburo Sakoda, Ashley I Bush

Journal article  |  2007  |  Free Radical Biology and Medicine

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Mechanisms of Copper Ion Mediated Huntington's Disease Progression

Jonathan H Fox, Jibrin A Kama, Gregory Lieberman, Raman Chopra, Kate Dorsey, Vanita Chopra, Irene Volitakis, Robert A Cherny, Ashley I Bush, Steven Hersch

Journal article  |  2007  |  PLoS One

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Metals, oxidative stress, and brain biology

D FINKELSTEIN, T LYNCH, S WILKINS, R CHERNY, A BUSH

Book Chapter  |  2007

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Metals, Oxidative Stress, and Brain Biology

DI Finkelstein, T Lynch, S Wilkins, RA Cherny, AI Bush

Book Chapter  |  2007

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Alzheimer disease beta-amyloid activity mimics cholesterol oxidase (vol 116, pg 2828, 2006)

Luigi Puglielli, Avi L Friedlich, Kenneth DR Setchell, Seiichi Nagano, Carlos Opazo, Robert A Cherny, Kevin J Barnham, John D Wade, Simon Melov, Dora M Kovacs, Ashley I Bush

Journal article  |  2006  |  Journal of Clinical Investigation

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Therapeutic treatments for Alzheimer's disease based on metal bioavailability

Peter J Crouch, Kevin J Barnham, Ashley I Bush, Anthony R White

Journal article  |  2006  |  Drug News & Perspectives

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The role of metal ions in neurology. An introduction

D Strozyk, AI Bush

Book Chapter  |  2006

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Neurodegenerative diseases and metal ions. A concluding overview

D Strozyk, AI Bush

Book Chapter  |  2006

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Elevated cortical zinc in Alzheimer disease

D Religa, D Strozyk, RA Cherny, I Volitakis, V Haroutunian, B Winblad, J Naslund, AI Bush

Journal article  |  2006  |  Neurology

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RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine.

Stephanie Tucker, Michelle Ahl, Hyun-Hee Cho, Sanghamitra Bandyopadhyay, Gregory D Cuny, Ashley I Bush, Lee E Goldstein, David Westaway, Xudong Huang, Jack T Rogers

Journal article  |  2006  |  Current Alzheimer Research

Lead compounds directed to the 5' leader of the Amyloid Precursor Protein transcript (i.e., paroxetine (SSRI), N-acetyl cysteine (..

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Clioquinol induces metal-dependent degradation of the Alzheimer's disease amyloid beta peptide by up-regulation of matrix metalloproteases

AR White, T Du, KM Laughton, I Volitakis, RA Sharples, DE Hoke, RMD Holsinger, G Evin, RA Cherny, AF Hill, KJ Barnham, QX Li, A Bush, CL Masters

Conference Proceedings  |  2006  |  JOURNAL OF NEUROCHEMISTRY

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Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

Anthony R White, Tai Du, Katrina M Laughton, Irene Volitakis, Robyn A Sharples, Michel E Xilinas, David E Hoke, RM Damian Holsinger, Genevieve Evin, Robert A Cherny, Andrew F Hill, Kevin J Barnham, Qiao-Xin Li, Ashley I Bush, Colin L Masters

Journal article  |  2006  |  Journal of Biological Chemistry

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Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge

David P Smith, Danielle G Smith, Cyril C Curtain, John F Boas, John R Pilbrow, Giuseppe D Ciccotosto, Tong-Lay Lau, Deborah J Tew, Keyla Perez, John D Wade, Ashley I Bush, Simon C Drew, Frances Separovic, Colin L Masters, Roberto Cappai, Kevin J Barnham

Journal article  |  2006  |  Journal of Biological Chemistry

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Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: Implications for Alzheimer beta-amyloid pathology

Christa J Maynard, Roberto Cappai, Irene Volitakis, Robert A Cherny, Colin L Masters, Qiao-Xin Li, Ashley I Bush

Journal article  |  2006  |  Journal of Inorganic Biochemistry

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Metal homeostasis in Alzheimer's disease

Anthony R White, Kevin J Barnham, Ashley I Bush

Journal article  |  2006  |  Expert Review of Neurotherapeutics

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Metal homeostasis in Alzheimer's disease.

Anthony R White, Kevin J Barnham, Ashley I Bush

Journal article  |  2006  |  Expert Review of Neurotherapeutics

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by neuronal dysfunction and the formation of am..

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Elevated cortical zinc in Alzheimer's disease

D Strozyk, D Religa, R Cherny, I Volitakis, V Haroutunian, B Winblad, J Naslund, AI Bush

Conference Proceedings  |  2006  |  NEUROLOGY

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Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn2 complexes in Alzheimer's disease

C Opazo, S Luza, VL Villemagne, I Volitakis, C Rowe, KJ Barnham, D Strozyk, CL Masters, RA Cherny, AI Bush

Journal article  |  2006  |  Aging Cell

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Free radicals, metal ions and Abeta aggregation and neurotoxicity

K BARNHAM, A BUSH

Book Chapter  |  2006

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Metals and Alzheimer's disease

PA Adlard, AI Bush

Journal article  |  2006  |  Journal of Alzheimer's Disease

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Hypoxia-inducible factor prolyl 4-hydroxylase inhibition - A target for neuroprotection in the central nervous system

A Siddiq, IA Ayoub, JC Chavez, L Aminova, S Shah, JC LaManna, SM Patton, JR Connor, RA Cherny, I Volitakis, AI Bush, I Langsetmo, T Seeley, V Gunzler, RR Ratan

Journal article  |  2005  |  Journal of Biological Chemistry

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Model studies of cholesterol and ascorbate oxidation by copper complexes: Relevance to Alzheimer's disease beta-amyloid metallochemistry

F Haeffner, DG Smith, KJ Barnham, AI Bush

Journal article  |  2005  |  Journal of Inorganic Biochemistry

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Alzheimer research forum live discussion: Role and control of metal-mediated fibril toxicity

D Allsop, A Bush, F Haeffner, T Fagan, M Smith, D Walsh, A Boom, D Dickstein, R Karlnoski, A McCaddon

Journal article  |  2005  |  Journal of Alzheimer's Disease

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Alzheimer disease beta-amyloid activity mimics cholesterol oxidase

L Puglielli, AL Friedlich, KDR Setchell, S Nagano, C Opazo, RA Cherny, KJ Barnham, JD Wade, S Melov, DM Kovacs, AI Bush

Journal article  |  2005  |  Journal of Clinical Investigation

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Metals and amyloid-beta in Alzheimer's disease

CJ Maynard, AI Bush, CL Masters, R Cappai, QX Li

Journal article  |  2005  |  International Journal of Experimental Pathology

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Methionine regulates copper/hydrogen peroxide oxidation products of A beta

FE Ali, F Separovic, CJ Barrow, RA Cherny, F Fraser, AI Bush, CL Masters, KJ Barnham

Journal article  |  2005  |  Journal of Peptide Science

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The neurobiology of zinc in health and disease

CJ Frederickson, JY Koh, AI Bush

Journal article  |  2005  |  Nature Reviews Neuroscience

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Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutaselike structures and inhibition of neurotoxicity

AK Tickler, DG Smith, GD Ciccotosto, DJ Tew, CC Curtain, D Carrington, CL Masters, AI Bush, RA Cherny, R Cappai, JD Wade, KJ Barnham

Journal article  |  2005  |  Journal of Biological Chemistry

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Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region.

Stephanie Tucker, Michelle Ahl, Ashley Bush, David Westaway, Xudong Huang, Jack T Rogers

Journal article  |  2005  |  Current Alzheimer Research

A pilot study was conducted employing a well known mouse model for Alzheimer's disease to evaluate the anti-amyloid efficacy of th..

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A beta 42 inversely correlated with copper and zinc in cerebrospinal fluid

D Strozyk, AI Bush, RA Cherny, LR White, I Volitakis, LJ Launer

Conference Proceedings  |  2005  |  NEUROLOGY

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Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment

S Melov, N Wolf, D Strozyk, SR Doctrow, AI Bush

Journal article  |  2005  |  Free Radical Biology and Medicine

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Methionine sulfoxide reductase system: Possible roles in protection against neurodegenerative diseases

J Moskovitz, AI Bush

Book Chapter  |  2005

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Modulation of intracellular amyloid-beta-peptide aggregation by copper in Caenorhabditis elegans

A Minniti, P Grez, C Opazo, I Volitakis, R Cherny, C Masters, A Bush, N Inestrosa

Conference Proceedings  |  2005  |  New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2005

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Copper and zinc in Alzheimer's disease and amyotrophic lateral sclerosis

AL Friedlich, AI Bush

Book Chapter  |  2005

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Amyloid-beta metal interaction and metal chelation.

Math P Cuajungco, Christopher J Frederickson, Ashley I Bush

Book Chapter  |  2005  |  Subcellular Biochemistry

Alzheimer's disease (AD) is associated with the abnormal aggregation of amyloid-beta (Abeta) protein. Abeta and its precursor prot..

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Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's A beta peptides

XD Huang, CS Atwood, RD Moir, MA Hartshorn, RE Tanzi, AI Bush

Journal article  |  2004  |  Journal of Inorganic Biochemistry

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Metal-protein attenuating compounds and Alzheimer"s disease

CW Ritchie, AI Bush, CL Masters

Journal article  |  2004  |  Expert Opinion on Investigational Drugs

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Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis

A Dedeoglu, K Cormier, S Payton, KA Tseitlin, JN Kremsky, L Lai, XH Li, RD Moir, RE Tanzi, AI Bush, NW Kowall, JT Rogers, XD Huang

Conference Proceedings  |  2004  |  Experimental Gerontology

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Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution

GD Ciccotosto, D Tew, CC Curtain, D Smith, D Carrington, CL Masters, AI Bush, RA Cherny, R Cappai, KJ Barnham

Journal article  |  2004  |  Journal of Biological Chemistry

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Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis

M Kiaei, AI Bush, BM Morrison, JH Morrison, RA Cherny, I Volitakis, MF Beal, JW Gordon

Journal article  |  2004  |  Journal of Neuroscience

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The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2 neurotoxicity in vivo

WF Cerpa, MI Barria, MA Chacon, M Suazo, M Gonzalez, C Opazo, AI Bush, NC Inestrosa

Journal article  |  2004  |  FASEB Journal

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Mutagenesis-toxicity studies of the amyloid beta peptide of Alzheimer's disease

GD Ciccotosto, CC Curtain, D Tew, D Carrington, CL Masters, RA Cherny, AI Bush, R Cappai, KJ Barnham

Conference Proceedings  |  2004  |  Neurobiology of Aging

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Alzheimer's disease drug discovery targeted to the APP MRNA 5 ' untranslated region, a validated target

JT Rogers, S Payton, NH Greig, R Jensen, G Cuny, DK Lahiri, LJ Morse, RE Tanzi, D Westaway, A Bush, S Gullans, S Sarang, XD Huang

Conference Proceedings  |  2004  |  Neurobiology of Aging

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The mechanism by which A beta produces hydrogen peroxide and its role in neurotoxicity

KJ Barnham, F Haeffner, GD Ciccotosto, CC Curtain, D Tew, CL Masters, RA Chemy, R Cappai, AI Bush

Conference Proceedings  |  2004  |  Neurobiology of Aging

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Copper and zinc in Alzheimer's disease: From bench to clinic

AI Bush

Conference Proceedings  |  2004  |  Neurobiology of Aging

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Clioquinol targets metallated abeta in human Alzheimer's and Tg2576 mouse brains

CR Opazo, S Luza, I Volitakis, CL Masters, AI Bush, R Chemy

Conference Proceedings  |  2004  |  Neurobiology of Aging

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(A beta) in human lens & aqueous humor: Further characterization of a novel AD biomarker

LE Goldstein, DM Hartley, RD Moir, EA Blakely, PI Chang, MA Marcus, M Martin-Rehrmann, G Ko, MH Ericsson, XD Huang, RE Tanzi, AI Bush, LT Chylack

Conference Proceedings  |  2004  |  Neurobiology of Aging

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Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

KJ Barnham, F Haeffner, GD Ciccotosto, CC Curtain, D Tew, C Mavros, K Beyreuther, D Carrington, CL Masters, RA Cherny, R Cappai, AI Bush

Journal article  |  2004  |  FASEB Journal

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N-acetyl-cysteine treatment inhibits depletion of brain glutathione levels in rats: Implications for Schizophrenia

O Dean, M van den Buuse, D Copolov, M Berk, A Bush

Conference Proceedings  |  2004  |  INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

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Alzheimer's amyloid beta-peptide (1-42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide

DA Butterfield, AI Bush

Journal article  |  2004  |  Neurobiology of Aging

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Serum copper - A biomarker for Alzheimer disease?

AI Bush, D Strozyk

Journal article  |  2004  |  Archives of Neurology

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Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (A beta) and generates A beta-COX-2 hetero-oligomers that are increased in Alzheimer's disease

S Nagano, XD Huang, RD Moir, SM Payton, RE Tanzi, AI Bush

Journal article  |  2004  |  Journal of Biological Chemistry

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Iron inhibits neurotoxicity induced by trace copper and biological reductants

AR White, KJ Barnham, X Huang, I Voltakis, K Beyreuther, CL Masters, RA Cherny, AI Bush, R Cappai

Journal article  |  2004  |  Journal of Biological Inorganic Chemistry

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Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid beta-peptide by NMR

SG Yao, RA Cherny, AI Bush, CL Masters, KJ Barnham

Journal article  |  2004  |  Journal of Peptide Science

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Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease

AL Friedlich, JY Lee, T van Groen, RA Cherny, I Volitakis, TB Cole, RD Palmiter, JY Koh, AI Bush

Journal article  |  2004  |  Journal of Neuroscience

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Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain

JY Lee, JH Kim, SH Hong, JY Lee, RA Cherny, AI Bush, RD Palmiter, JY Koh

Journal article  |  2004  |  Journal of Biological Chemistry

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Neurodegenerative diseases and oxidative stress

KJ Barnham, CL Masters, AI Bush

Journal article  |  2004  |  Nature Reviews Drug Discovery

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Redox-mediated A beta neurotoxicity

KJ Barnham, R Cappai, RA Cherny, AI Bush, CL Masters

Conference Proceedings  |  2004  |  JOURNAL OF NEUROCHEMISTRY

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Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta

CS Atwood, G Perry, H Zeng, Y Kato, WD Jones, KQ Ling, XD Huang, RD Moir, DD Wang, LM Sayre, MA Smith, SG Chen, AI Bush

Journal article  |  2004  |  Biochemistry

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Redox-active metals, oxidative stress, and Alzheimer's disease pathology

XD Huang, RD Moir, RE Tanzi, AI Bush, JT Rogers

Journal article  |  2004  |  Annals of The New York Academy of Sciences

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Metal-Protein Attenuating Compounds (MPACs) for the Treatment of Alzheimers Disease

Kevin Barnham, Robert Cherny, Roberto Cappai, Simon Melov, Colin Masters, Ashley Bush

Journal article  |  2004  |  Drug Design Reviews Online

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The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5 '-untranslated region

A Venti, T Giordano, P Eder, AI Bush, DK Lahiri, NH Greig, JT Rogers

Conference Proceedings  |  2004  |  Annals of the New York Academy of Sciences

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Cholesterol oxidase activity mediates neurotoxicity of the Alzheimer beta-amyloid cuproprotein

AI Bush, L Puglielli, S Nagano, DM Kovacs

Conference Proceedings  |  2003  |  JOURNAL OF NEUROCHEMISTRY

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting A beta amyloid deposition and toxicity in Alzheimer disease - A pilot phase 2 clinical trial

CW Ritchie, AI Bush, A Mackinnon, S Macfarlane, M Mastwyk, L MacGregor, L Kiers, R Cherny, QX Li, A Tammer, D Carrington, C Mavros, I Volitakis, M Xilinas, D Ames, S Davis, I Volitakis, M Xilinas, D Ames, S Davis, et al.

Journal article  |  2003  |  Archives of Neurology

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Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

KJ Barnham, GD Ciccotosto, AK Tickler, FE Ali, DG Smith, NA Williamson, YH Lam, D Carrington, D Tew, G Kocak, I Volitakis, F Separovic, CJ Barrow, JD Wade, CL Masters, RA Cherny, CC Curtain, AI Bush, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

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Copper, beta-amyloid, and Alzheimer's disease: Tapping a sensitive connection

AI Bush, CL Masters, RE Tanzi

Journal article  |  2003  |  Proceedings of the National Academy of Sciences of the United States of America

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Medicinal metallochemistry of Alzheimer's disease.

AI Bush

Conference Proceedings  |  2003  |  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

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Current status of metals as therapeutic targets in Alzheimer's disease

AE Finefrock, AI Bush, PM Doraiswamy

Journal article  |  2003  |  Journal of the American Geriatrics Society

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Beta-amyloid cuproprotein: A therapeutic target for Alzheimer's disease

AI Bush

Conference Proceedings  |  2003  |  Journal of Inorganic Biochemistry

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Copper, zinc, and the metallobiology of Alzheimer disease

AI Bush

Journal article  |  2003  |  Alzheimer Disease and Associated Disorders

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Expression and further characterization of Alzheimer's disease beta-amyloid (Abeta) in human aqueous humor and lens

LE Goldstein, R Moir, R Cherny, R Pineda, E Blakely, P Chang, K Bjornstad, R Tanzi, A Bush, LT Chylack

Conference Proceedings  |  2003  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

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Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease

LE Goldstein, JA Muffat, RA Cherny, RD Moir, MH Ericsson, XD Huang, C Mavros, JA Coccia, KY Faget, KA Fitch, CL Masters, RE Tanzi, LT Chylack, AI Bush

Journal article  |  2003  |  The Lancet

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The metallobiology of Alzheimer's disease

AI Bush

Journal article  |  2003  |  Trends in Neurosciences

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Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: A novel therapy for Parkinson's disease

D Kaur, F Yantiri, S Rajagopalan, J Kumar, JO Mo, R Boonplueang, V Viswanath, R Jacobs, L Yang, MF Beal, D DiMonte, I Volitaskis, L Ellerby, RA Cherny, AI Bush, JK Andersen

Journal article  |  2003  |  Neuron

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The Medicinal Metallochemistry of Alzheimers Disease

Robert Cherny, Colin Masters, Ashley Bush

Journal article  |  2003  |  Current Medicinal Chemistry - Immunology, Endocrine and Metabolic Agents

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Losing my mind - An intimate look at life with Alzheimer's

AI Bush

Journal article  |  2003  |  Science

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Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid

CC Curtain, FE Ali, DG Smith, AI Bush, CL Masters, KJ Barnham

Journal article  |  2003  |  Journal of Biological Chemistry

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To write a book, to plant a tree...

AI BUSH

Journal article  |  2003  |  Science

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Methionine oxidation: Implications for the mechanism of toxicity of the beta-amyloid peptide from Alzheimer's disease

GD Ciccotosto, KJ Barnham, RA Cherny, CL Masters, AI Bush, CC Curtain, R Cappai, D Tew

Journal article  |  2003  |  Letters in Peptide Science

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Aβ metallobiology and the development of novel metal-compounds (MPACs) for Alzheimer's disease

CC CURTAIN, KJ BARNHAM, AI BUSH

Journal article  |  2003  |  Current Medicinal Chemistry - Immunology, Endocrine and Metabolic Agents

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Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.

G EVIN, undefined Sernee, K BARNHAM, undefined Holsinger, J CULVENOR, D HOKE, Q LI, undefined Smith, C MAYNARD, N WILLIAMSON, G CICCOTOSTO, S MOK, I VOLITAKIS, G KOCAK, undefined Carrington, undefined Opazo, AK TICKLER, undefined Huang, undefined Beyreuther, R CAPPAI, et al.

Book Chapter  |  2003

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Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

CJ Maynard, R Cappai, I Volitakis, RA Cherny, AR White, K Beyreuther, CL Masters, AI Bush, QX Li

Journal article  |  2002  |  Journal of Biological Chemistry

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An iron-responsive element type II in the 5 '-untranslated region of the Alzheimer's amyloid precursor protein transcript

JT Rogers, JD Randall, CM Cahill, PS Eder, XD Huang, H Gunshin, L Leiter, J McPhee, SS Sarang, T Utsuki, NH Greig, DK Lahiri, RE Tanzi, AI Bush, T Giordano, SR Gullans

Journal article  |  2002  |  Journal of Biological Chemistry

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Metal complexing agents as therapies for Alzheimer's disease

AI Bush

Journal article  |  2002  |  Neurobiology of Aging

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"Emerging Alzheimer's disease therapies: focusing on the future"

JQ Trojanowski

Conference Proceedings  |  2002  |  Neurobiology of Aging

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid - Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H2O2

C Opazo, XD Huang, RA Cherny, RD Moir, AE Roher, AR White, R Cappai, CL Masters, RE Tanzi, NC Inestrosa, AI Bush

Journal article  |  2002  |  Journal of Biological Chemistry

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Is ALS caused by an altered oxidative activity of mutant superoxide dismutase? [1] (multiple letters)

AI Bush, PC Wong

Journal article  |  2002  |  Nature Neuroscience

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Is ALS caused by an altered oxidative activity of mutant superoxide dismutase?

AI Bush

Journal article  |  2002  |  Nature Neuroscience

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Alzheimer's disease drug discovery targeted to the APP mRNA 5 ' untranslated region

JT Rogers, JD Randall, PS Eder, XD Huang, AI Bush, RE Tanzi, A Venti, SM Payton, T Giordano, S Nagano, CM Cahill, R Moir, DK Lahiri, N Greig, SS Sarang, SR Gullans

Journal article  |  2002  |  Journal of Molecular Neuroscience

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Oxidative stress, mitochondria-dependent cell death and A beta amyloidosis

XD Huang, ZH Qiu, J Rogers, A Bush, R Tanzi, G Tesco, W Rebeck

Conference Proceedings  |  2002  |  NEUROBIOLOGY OF AGING

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Overexpression of the beta-amyloid protein regulates metal levels in transgenic mouse brain

C Maynard, R Cappai, A White, C Masters, I Volitakis, R Cherny, K Beyreuther, A Bush

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

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Serial evaluation of asymptomatic mild cognitive impairment (MCI) using computerised testing

D Darby, P Maruff, A Collie, A Bush

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

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Beta-amyloid in the lens: A novel AD biomarker?

L Goldstein, J Muffat, R Moir, J Goto, A Saunders, A Friedlich, XD Huang, J Coccia, K Faget, R Tanzi, A Bush, R Cherny, M Ericsson, I Delalle, K Newell, ET Hedley-Whyte, L Chylack

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

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Clioquinol inhibits the copper-catalysed generation of H2O2 by A-beta

R Cherny, D Carrington, CL Masters, C Opazo, AI Bush

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

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Factors regulating the interactions between amyloid-beta and membrane lipids

K Barnham, D Smith, D Carrington, G Kocak, I Volitakis, R Cherny, R Cappai, C Masters, A Bush, C Curtain, F Ali, C Barrow, A Tickler, J Wade

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

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Iron oxidation and neuroprotection by secreted amyloid precursor protein

J Rogers, J Goto, XD Huang, A Venti, R Moir, R Tanzi, A Bush

Conference Proceedings  |  2002  |  NEUROBIOLOGY OF AGING

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Clioquinol, inhibits copper-catalysed H2O2 production by A-beta

R Cherny, D Carrington, C Masters, XD Huang, A Bush

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

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The galvanization of beta-amyloid in Alzheimer's disease

AI Bush, RE Tanzi

Journal article  |  2002  |  Proceedings of the National Academy of Sciences of the United States of America

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Beta-amyloid promotes lens protein aggregation and is associated with supranuclear lens opacification

LE Goldstein, JA Muffat, RA Cherny, JA Coccia, I Delalle, MH Ericsson, RD Moir, RE Tanzi, AI Bush, LT Chylack

Conference Proceedings  |  2002  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

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Response: ‘…and C is for Clioquinol’ – the AβCs of Alzheimer's disease

Ashley Bush

Journal article  |  2002  |  Trends in Neurosciences

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'...and C is for clioquinol' - the A beta Cs of Alzheimer's disease - Response

A Bush

Journal article  |  2002  |  TRENDS IN NEUROSCIENCES

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Brain zinc: physiology and pathophysiology

AI BUSH, CJ FREDERICKSON

Journal article  |  2002  |  Biometals

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Copper, zinc and Alzheimer's disease

AL FRIEDLICH, S NAGANO, AI BUSH

Book Chapter  |  2002

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Computerised cognitive assessment of concussed Australian Rules footballers

M Makdissi, A Collie, P Maruff, DG Darby, A Bush, P McCrory, K Bennell

Journal article  |  2001  |  British Journal of Sports Medicine

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Synaptically released zinc: Physiological functions and pathological effects

CJ Frederickson, AI Bush

Journal article  |  2001  |  Biometals

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Abnormal catalytic redox activity of A beta in Alzheimer's disease, and SOD in ALS

AI Bush

Journal article  |  2001  |  JOURNAL OF NEUROCHEMISTRY

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Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126

MF Jobling, XD Huang, LR Stewart, KJ Barnham, C Curtain, I Volitakis, M Perugini, AR White, RA Cherny, CL Masters, CJ Barrow, SJ Collins, AI Bush, R Cappai

Journal article  |  2001  |  Biochemistry

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Therapeutic targets in the biology of Alzheimer's disease

AI Bush

Journal article  |  2001  |  Current Opinion in Psychiatry

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Clioquinol's return: Cautions from Japan

T Tabira

Journal article  |  2001  |  Science

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Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

CC Curtain, F Ali, I Volitakis, RA Cherny, RS Norton, K Beyreuther, CJ Barrow, CL Masters, AI Bush, KJ Barnham

Journal article  |  2001  |  Journal of Biological Chemistry

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice

RA Cherny, CS Atwood, ME Xilinas, DN Gray, WD Jones, CA McLean, KJ Barnham, I Volitakis, FW Fraser, YS Kim, XD Huang, LE Goldstein, RD Moir, JT Lim, K Beyreuther, H Zheng, RE Tanzi, CL Masters, AI Bush

Journal article  |  2001  |  Neuron

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A beta peptides in human and amyloid-bearing transgenic mouse lens: Implications for Alzheimer's disease and cataracts.

L Goldstein, J Muffat, R Cherny, K Faget, J Coccia, F Fraser, C Masters, R Tanzi, L Chylack, A Bush

Journal article  |  2001  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

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Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways

AR White, XD Huang, MF Jobling, CJ Barrow, K Beyreuther, CL Masters, AI Bush, R Cappai

Journal article  |  2001  |  Journal of Neurochemistry

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Redox-active iron mediates amyloid-beta toxicity

CA Rottkamp, AK Raina, XW Zhu, E Gaier, AI Bush, CS Atwood, M Chevion, G Perry, MA Smith

Journal article  |  2001  |  Free Radical Biology and Medicine

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Parallels between the redox properties and toxicity of A beta in Alzheimer's disease and mutant Cu/Zn-SOD in familial amyotrophic lateral sclerosis

AI Bush

Book Chapter  |  2001

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Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts.

AI Bush, LE Goldstein

Journal article  |  2001  |  Novartis Foundation Symposium

Abnormalities of protein aggregation and deposition may play an important role in the pathophysiology of a diverse set of chronica..

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Clinoquinol's return: cautions from Japan

AI BUSH, CL MASTERS

Journal article  |  2001  |  Science

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Neuroinflammatory responses in the Alzheimer's disease brain promote the oxidative post-translational modification of amyloid deposits

CS Atwood, XD Huang, RD Moir, MA Smith, RE Tanzi, AE Roher, AI Bush, G Perry

Book Chapter  |  2001

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Characterization of copper interactions with Alzheimer amyloid beta peptides: Identification of an attomolar-affinity copper binding site on amyloid beta 1-42

CS Atwood, RC Scarpa, XD Huang, RD Moir, WD Jones, DP Fairlie, RE Tanzi, AI Bush

Journal article  |  2000  |  Journal of Neurochemistry

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The pools of soluble and insoluble A beta amyloid in Alzheimer's disease and normal ageing.

C McLean, RA Cherny, F Fraser, K Beyreuther, A Bush

Conference Proceedings  |  2000  |  BRAIN PATHOLOGY

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N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis

OA Andreassen, A Dedeoglu, P Klivenyi, MF Beal, AI Bush

Journal article  |  2000  |  NeuroReport

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Oxidative processes in Alzheimer's disease: the role of A beta-metal interactions

T Lynch, RA Cherny, AI Bush

Journal article  |  2000  |  Experimental Gerontology

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Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of A beta by zinc

MP Cuajungco, LE Goldstein, A Nunomura, MA Smith, JT Lim, CS Atwood, XD Huang, YW Farrag, G Perry, AI Bush

Journal article  |  2000  |  Journal of Biological Chemistry

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3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction

LE Goldstein, MC Leopold, XD Huang, CS Atwood, AJ Saunders, M Hartshorn, JT Lim, KY Faget, JA Muffat, RC Scarpa, LT Chylack, EF Bowden, RE Tanzi, AI Bush

Journal article  |  2000  |  Biochemistry

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Chelation and intercalation: Complementary properties in a compound for the treatment of Alzheimer's disease

RA Cherny, KJ Barnham, T Lynch, I Volitakis, QX Li, CA McLean, G Multhaup, K Beyreuher, RE Tanzi, CL Masters, AI Bush

Journal article  |  2000  |  Journal of Structural Biology

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Copper catalyzed oxidation of alzheimer A beta

CS Atwood, XD Huang, A Khatri, RC Scarpa, YS Kim, RD Moir, RE Tanzi, AE Roher, AI Bush

Journal article  |  2000  |  Cellular and molecular biology (Noisy-le-Grand, France)

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Could Abeta and AbetaPP be Antioxidants?

Ashley I Bush, Craig S Atwood, Lee E Goldstein, Xudong Huang, Jack Rogers

Journal article  |  2000  |  Journal of Alzheimer's Disease

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Alzheimer's disease, beta-amyloid protein and zinc.

X Huang, MP Cuajungco, CS Atwood, RD Moir, RE Tanzi, AI Bush

Conference Proceedings  |  2000  |  The Journal of Nutrition

Alzheimer's disease (AD) is characterized by amyloid deposits within the neocortical parenchyma and the cerebrovasculature. The ma..

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Alzheimer's disease, beta-amyloid protein and zinc

XD Huang, MP Cuajungco, CS Atwood, RD Moir, RE Tanzi, AI Bush

Conference Proceedings  |  2000  |  JOURNAL OF NUTRITION

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Metals and neuroscience

AI Bush

Journal article  |  2000  |  Current Opinion in Chemical Biology

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Lens epithelium-derived growth factor (LEDGF) in the retina and brain.

LE Goldstein, E Kubo, DP Singh, AI Bush, LT Chylack, T Shinohara

Conference Proceedings  |  2000  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

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Metal chelation as a potential therapy for Alzheimer's disease

MP Cuajungco, KY Faget, XD Huang, RE Tanzi, AI Bush

Conference Proceedings  |  2000  |  Annals of the New York Academy of Sciences

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Cu(II) potentiation of Alzheimer A beta neurotoxicity - Correlation with cell-free hydrogen peroxide production and metal reduction

XD Huang, MP Cuajungco, CS Atwood, MA Hartshorn, JDA Tyndall, GR Hanson, KC Stokes, M Leopold, G Multhaup, LE Goldstein, RC Scarpa, AJ Saunders, J Lim, RD Moir, C Glabe, EF Bowden, CL Masters, DP Fairlie, RE Tanzi, AI Bush

Journal article  |  1999  |  Journal of Biological Chemistry

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Soluble pool of A beta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

CA McLean, RA Cherny, FW Fraser, SJ Fuller, MJ Smith, K Beyreuther, AI Bush, CL Masters

Journal article  |  1999  |  Annals of Neurology

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Elevated serum concentrations of fibroblast factor (FGF) in patients with multiple myeloma (MM).

AZ Zhu, M Fleischer, A Bush, B Childs, R Pearse, R Weider, J Michaeli

Conference Proceedings  |  1999  |  BLOOD

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The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures

AR White, G Multhaup, F Maher, S Bellingham, J Camakaris, H Zheng, AI Bush, K Beyreuther, CL Masters, R Cappai

Journal article  |  1999  |  The Journal of Neuroscience

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Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

AR White, R Reyes, JFB Mercer, J Camakaris, H Zheng, AI Bush, G Multhaup, K Beyreuther, CL Masters, R Cappai

Journal article  |  1999  |  Brain Research

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Aqueous dissolution of Alzheimer's disease A beta amyloid deposits by biometal depletion

RA Cherny, JT Legg, CA McLean, DP Fairlie, XD Huang, CS Atwood, K Beyreuther, RE Tanzi, CL Masters, AI Bush

Journal article  |  1999  |  Journal of Biological Chemistry

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Mounting evidence for the involvement of zinc and copper in Alzheimer's disease

RD Moir, CS Atwood, X Huang, RE Tanzi, AI Bush

Journal article  |  1999  |  European Journal of Clinical Investigation

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The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction

X Huang, CS Atwood, MA Hartshorn, G Multhaup, LE Goldstein, RC Scarpa, MP Cuajungco, DN Gray, J Lim, RD Moir, RE Tanzi, AI Bush

Journal article  |  1999  |  Biochemistry

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The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction

XD Huang, CS Atwood, MA Hartshorn, G Multhaup, LE Goldstein, RC Scarpa, MP Cuajungco, DN Gray, J Lim, RD Moir, RE Tanzi, AI Bush

Journal article  |  1999  |  Biochemistry

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Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice

QX Li, C Maynard, R Cappai, CA McLean, RA Cherny, T Lynch, JG Culvenor, J Trevaskis, JE Tanner, KA Bailey, C Czech, AI Bush, K Beyreuther, CL Masters

Journal article  |  1999  |  Journal of Neurochemistry

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The possible origin of free radicals from amyloid beta peptides in Alzheimer's disease

AI Bush, XD Huang, DP Fairlie

Journal article  |  1999  |  Neurobiology of Aging

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Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione

AR White, AI Bush, K Beyreuther, CL Masters, R Cappai

Journal article  |  1999  |  Journal of Neurochemistry

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Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations

RD Moir, CS Atwood, DM Romano, MH Laurans, XD Huang, AI Bush, JD Smith, RE Tanzi

Journal article  |  1999  |  Biochemistry

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The tryptophan metabolites 3-hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin polymerization by metal ion reduction

L Goldstein, M Leopold, X Huang, E Bowden, R Tanzi, A Bush

Conference Proceedings  |  1999  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

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Anti-apoptotic action of Alzheimer A beta

CW Chan, A Dharmarajan, CS Atwood, XD Huang, RE Tanzi, AI Bush, RN Martins

Journal article  |  1999  |  Alzheimer's Reports

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Zinc and Alzheimer's Disease: An Update.

MP Cuajungco, GJ Lees, RR Kydd, RE Tanzi, AI Bush

Journal article  |  1999  |  Nutritional Neuroscience

Zinc is an essential metal in human nutrition. A growing number of observations have implicated zinc in the pathophysiology of Alz..

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Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease

CS Atwood, XD Huang, RD Moir, RE Tanzi, AI Bush

Journal article  |  1999  |  Metal ions in biological systems

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Metal-catalyzed redox activity of A beta - The major source of amyloid-associated oxidative stress in Alzheimer's disease

XD Huang, CS Atwood, LE Goldstein, MA Hartshorn, AJ Saunders, RD Moir, RE Tanzi, AI Bush

Conference Proceedings  |  1999  |  ALZHEIMER'S DISEASE AND RELATED DISORDERS

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Potential therapeutic targets for Alzheimer's disease

C McKeon-O'Malley, AJ Saunders, AI Bush, RE Tanzi

Journal article  |  1998  |  Emerging Therapeutic Targets

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beta-amyloid augments platelet aggregation: reduced activity of familial angiopathy-associated mutants

B Wolozin, S Maheshwari, C Jones, R Dukoff, W Wallace, M Racchi, S Nagula, NR Shulman, T Sunderland, A Bush

Journal article  |  1998  |  Molecular Psychiatry

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Alzheimer disease-related abnormalities of amyloid beta precursor protein isoforms in the platelet - The brain's delegate in the periphery?

AI Bush, RE Tanzi

Journal article  |  1998  |  Archives of Neurology

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Dramatic aggregation of Alzheimer A beta by Cu(II) is induced by conditions representing physiological acidosis

CS Atwood, RD Moir, XD Huang, RC Scarpa, NME Bacarra, DM Romano, MK Hartshorn, RE Tanzi, AI Bush

Journal article  |  1998  |  Journal of Biological Chemistry

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Relative increase in Alzheimer's disease of soluble forms of cerebral A beta amyloid protein precursor containing the Kunitz protease inhibitory domain

RD Moir, T Lynch, AI Bush, S Whyte, A Henry, S Portbury, G Multhaup, DH Small, RE Tanzi, K Beyreuther, CL Masters

Journal article  |  1998  |  Journal of Biological Chemistry

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Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity

C Hock, S Golombowski, F Muller-Spahn, W Naser, K Beyreuther, U Monning, D Schenk, C Vigo-Pelfrey, AM Bush, R Moir, RE Tanzi, JH Growdon, RM Nitsch

Journal article  |  1998  |  European Neurology

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Zinc-induced Alzheimer's A beta 1-40 aggregation is mediated by conformational factors

XD Huang, CS Atwood, RD Moir, MA Hartshorn, JP Vonsattel, RE Tanzi, AI Bush

Journal article  |  1997  |  Journal of Biological Chemistry

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Metallothioneins in brain - The role in physiology and pathology

M Aschner, MG Cherian, CD Klaassen, RD Palmiter, JC Erickson, AI Bush

Journal article  |  1997  |  Toxicology and Applied Pharmacology

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The metabolism of the amyloid precursor protein of Alzheimer's disease and dietary zinc

S Whyte, L Jones, EJ Coulson, RD Moir, AI Bush, K Beyreuther, CL Masters

Conference Proceedings  |  1997  |  ALZHEIMER'S DISEASE: BIOLOGY, DIAGNOSIS AND THERAPEUTICS

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Neurochemical environments that precipitate A beta

CS Atwood, XD Huang, RD Moir, RE Tanzi, AI Bush

Conference Proceedings  |  1997  |  ALZHEIMER'S DISEASE: BIOLOGY, DIAGNOSIS AND THERAPEUTICS

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LDL RECEPTOR-RELATED PROTEIN (LRP) BINDS SECRETED BETA-AMYLOID PRECURSOR PROTEIN AND MEDIATES ITS DEGRADATION

MZ KOUNNAS, RD MOIR, GW REBECK, AI BUSH, WS ARGRAVES, RE TANZI, BT HYMAN, DK STRICKLAND

Conference Proceedings  |  1995  |  MOLECULAR BIOLOGY OF THE CELL

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LDL RECEPTOR-RELATED PROTEIN, A MULTIFUNCTIONAL APOE RECEPTOR, BINDS SECRETED BETA-AMYLOID PRECURSOR PROTEIN AND MEDIATES ITS DEGRADATION

MZ KOUNNAS, RD MOIR, GW REBECK, AI BUSH, WS ARGRAVES, RE TANZI, BT HYMAN, DK STRICKLAND

Journal article  |  1995  |  Cell

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ZINC AND MACULAR DEGENERATION

J HARTSTEIN, U PACE, ME HARTSTEIN, RE TANZI, AI BUSH

Journal article  |  1995  |  ANNALS OF OPHTHALMOLOGY & GLAUCOMA

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ZINC AND ALZHEIMERS-DISEASE - RESPONSE

AI BUSH, RD MOIR, KM ROSENKRANZ, RE TANZI

Journal article  |  1995  |  Science

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The role of zinc in the cerebral deposition of A beta amyloid in Alzheimer's disease

AI BUSH, RE TANZI

Conference Proceedings  |  1995  |  RESEARCH ADVANCES IN ALZHEIMER'S DISEASE AND RELATED DISORDERS

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HEAVY-METALS, GENES, AND NEURODEGENERATIVE DISORDERS - WILSONS-DISEASE AND ALZHEIMERS-DISEASE

RE TANZI, W WASCO, RD MOIR, AI BUSH

Conference Proceedings  |  1995  |  JOURNAL OF NEUROCHEMISTRY

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Zinc and Alzheimer's disease [8]

AI Bush, RD Moir, KM Rosenkranz, RE Tanzi

Journal article  |  1995  |  Science

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THE ROLE OF CEREBRAL ZINC-METABOLISM IN ALZHEIMERS-DISEASE A-BETA-AMYLOIDOSIS

AI BUSH, RD MOR, K ROSENKRANZ, L RODES, RE TANZI

Conference Proceedings  |  1995  |  JOURNAL OF NEUROCHEMISTRY

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INTERACTION BETWEEN THE ZINC(II) AND THE HEPARIN-BINDING SITE OF THE ALZHEIMERS-DISEASE BETA-A4 AMYLOID PRECURSOR PROTEIN (APP)

G MULTHAUP, AI BUSH, P POLLWEIN, CL MASTERS

Journal article  |  1994  |  FEBS Letters

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THE AMYLOID BETA-PROTEIN PRECURSOR AND ITS MAMMALIAN HOMOLOGS - EVIDENCE FOR A ZINC-MODULATED HEPARIN-BINDING SUPERFAMILY

AI BUSH, WH PETTINGELL, M DEPARADIS, RE TANZI, W WASCO

Journal article  |  1994  |  Journal of Biological Chemistry

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RAPID INDUCTION OF ALZHEIMER A-BETA AMYLOID FORMATION BY ZINC

AI BUSH, WH PETTINGELL, G MULTHAUP, MD PARADIS, JP VONSATTEL, JF GUSELLA, K BEYREUTHER, CL MASTERS, RE TANZI

Journal article  |  1994  |  Science

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MEMBRANE-ASSOCIATED FORMS OF THE BETA-A4 AMYLOID PROTEIN-PRECURSOR OF ALZHEIMERS-DISEASE IN HUMAN PLATELET AND BRAIN - SURFACE EXPRESSION ON THE ACTIVATED HUMAN PLATELET

QX LI, MC BERNDT, AI BUSH, B RUMBLE, I MACKENZIE, A FRIEDHUBER, K BEYREUTHER, CL MASTERS

Journal article  |  1994  |  Blood

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MODULATION OF A-BETA ADHESIVENESS AND SECRETASE SITE CLEAVAGE BY ZINC

AI BUSH, WH PETTINGELL, MD PARADIS, RE TANZI

Journal article  |  1994  |  Journal of Biological Chemistry

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GENETIC-STUDIES OF ALZHEIMERS-DISEASE - LESSONS LEARNED AND FUTURE IMPERATIVES

RE TANZI, AI BUSH, W WASCO

Journal article  |  1994  |  Neurobiology of Aging

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THE ROLE OF ZINC IN A-BETA AMYLOIDOSIS

AI BUSH, WH PETTINGELL, MD PARADIS, RE TANZI

Conference Proceedings  |  1994  |  NEUROBIOLOGY OF AGING

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THE WILSON DISEASE GENE IS A COPPER TRANSPORTING ATPASE WITH HOMOLOGY TO THE MENKES DISEASE GENE

RE TANZI, K PETRUKHIN, I CHERNOV, JL PELLEQUER, W WASCO, B ROSS, DM ROMANO, E PARANO, L PAVONE, LM BRZUSTOWICZ, M DEVOTO, J PEPPERCORN, AI BUSH, I STERNLIEB, M PIRASTU, JF GUSELLA, O EVGRAFOV, GK PENCHASZADEH, B HONIG, IS EDELMAN, et al.

Journal article  |  1993  |  Nature Genetics

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A NOVEL ZINC(II) BINDING-SITE MODULATES THE FUNCTION OF THE BETA-A4 AMYLOID PROTEIN-PRECURSOR OF ALZHEIMERS-DISEASE

AI BUSH, G MULTHAUP, RD MOIR, TG WILLIAMSON, DH SMALL, B RUMBLE, P POLLWEIN, K BEYREUTHER, CL MASTERS

Journal article  |  1993  |  Journal of Biological Chemistry

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GENETIC-HETEROGENEITY OF GENE DEFECTS RESPONSIBLE FOR FAMILIAL ALZHEIMER-DISEASE

R TANZI, S GASTON, A BUSH, D ROMANO, W PETTINGELL, J PEPPERCORN, M PARADIS, S GURUBHAGAVATULA, B JENKINS, W WASCO

Journal article  |  1993  |  Genetica

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THE BETA-A4 AMYLOID PROTEIN-PRECURSOR IN HUMAN CIRCULATION

AI BUSH, K BEYREUTHER, CL MASTERS

Conference Proceedings  |  1993  |  Annals of the New York Academy of Sciences

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HUMAN BRAIN-BETA-A4 AMYLOID PROTEIN-PRECURSOR OF ALZHEIMERS-DISEASE - PURIFICATION AND PARTIAL CHARACTERIZATION

RD MOIR, RN MARTINS, AI BUSH, DH SMALL, EA MILWARD, BA RUMBLE, G MULTHAUP, K BEYREUTHER, CL MASTERS

Journal article  |  1992  |  Journal of Neurochemistry

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Specific binding of the alzheimer βA4 amyloid precursor to collagen, laminin, and heparin

G Multhaup, AI Bush, P Pollwein, CL Masters, K Beyreuther

Journal article  |  1992  |  Journal of Protein Chemistry

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AN ABNORMALITY OF PLASMA AMYLOID PROTEIN-PRECURSOR IN ALZHEIMERS-DISEASE

AI BUSH, S WHYTE, LD THOMAS, TG WILLIAMSON, CJ VANTIGGELEN, J CURRIE, DH SMALL, RD MOIR, QX LI, B RUMBLE, U MONNING, K BEYREUTHER, CL MASTERS

Journal article  |  1992  |  Annals of Neurology

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BETA-A4 AMYLOID PROTEIN AND ITS PRECURSOR IN ALZHEIMERS-DISEASE

AI BUSH, K BEYREUTHER, CL MASTERS

Journal article  |  1992  |  Pharmacology & Therapeutics

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MECHANISMS OF AMYLOID DEPOSITION IN ALZHEIMERS-DISEASE

K BEYREUTHER, AI BUSH, T DYRKS, C HILBICH, G KONIG, U MONNING, G MULTHAUP, R PRIOR, B RUMBLE, W SCHUBERT, DH SMALL, A WEIDEMANN, CL MASTERS

Conference Proceedings  |  1991  |  Annals of the New York Academy of Sciences

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A PROTEASE ACTIVITY ASSOCIATED WITH ACETYLCHOLINESTERASE RELEASES THE MEMBRANE-BOUND FORM OF THE AMYLOID PROTEIN-PRECURSOR OF ALZHEIMERS-DISEASE

DH SMALL, RD MOIR, SJ FULLER, S MICHAELSON, AI BUSH, QX LI, E MILWARD, C HILBICH, A WEIDEMANN, K BEYREUTHER, CL MASTERS

Journal article  |  1991  |  Biochemistry

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MECHANISMS OF AMYLOID DEPOSITION IN ALZHEIMERS-DISEASE

K BEYREUTHER, AI BUSH, T DYRKS, C HILBICH, G KONIG, U MONNING, G MULTHAUP, R PRIOR, B RUMBLE, W SCHUBERT, DH SMALL, A WEIDEMANN, CL MASTERS

Conference Proceedings  |  1991  |  AGING AND ALZHEIMERS DISEASE

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CIRCULATING FORMS OF AMYLOID PRECURSOR PROTEIN OF ALZHEIMERS-DISEASE

AI BUSH, K BEYREUTHER, CL MASTERS

Conference Proceedings  |  1991  |  ALZHEIMERS DISEASE : BASIC MECHANISMS, DIAGNOSIS AND THERAPEUTIC STRATEGIES

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THE AMYLOID PRECURSOR PROTEIN OF ALZHEIMERS-DISEASE IS RELEASED BY HUMAN PLATELETS

AI BUSH, RN MARTINS, B RUMBLE, R MOIR, S FULLER, E MILWARD, J CURRIE, D AMES, A WEIDEMANN, P FISCHER, G MULTHAUP, K BEYREUTHER, CL MASTERS

Journal article  |  1990  |  Journal of Biological Chemistry

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HYPOTHALAMIC ATRIAL-NATRIURETIC-PEPTIDE SECRETION PLASTICITY - DIFFERENTIAL MODULATION OF ALPHA-ADRENOCEPTOR AND BETA-ADRENOCEPTOR

AI BUSH, WQ HUANG, DL COPOLOV, ATW LIM

Journal article  |  1990  |  Neuroendocrinology

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MEASUREMENT OF CYTOPLASMIC FREE CALCIUM IN SINGLE MOTILE CELLS

FR MAXFIELD, A BUSH, P MARKS, ML SHELANSKI

Conference Proceedings  |  1989  |  BIOCHEMICAL APPROACHES TO CELLULAR CALCIUM

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PROTEIN QUALITY OF COTTONSEED FLOUR

ML HARDEN, A BUSH, MW LAMB, SP YANG

Conference Proceedings  |  1971  |  FEDERATION PROCEEDINGS

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PARTICULATE MATTER IN MUNICIPAL INCINERATOR STACK DISCHARGES

H FROULA, A BUSH, R BYLOFF

Conference Proceedings  |  1951  |  ANALYTICAL CHEMISTRY

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Systematic review protocol: Quantitative susceptibility mapping of brain iron accumulation in neurodegenerative diseases.

Parsa Ravanfar, Samantha Loi, Tamsyn Van Rheenen, Ashley Bush, Patricia Desmond, Vanessa Cropley, Bradford Moffat, Dennis Velakoulis, Christos Pantelis

Journal article

Iron has been found to play an important role in neurodegeneration. Quantitative susceptibility mapping (QSM) is a relatively new,..

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Correction: Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine

Jianfang Chen, Eileen Marks, Barry Lai, Zhaojie Zhang, James A Duce, Linh Q Lam, Irene Volitakis, Ashley I Bush, Steven Hersch, Jonathan H Fox

Journal article  |  PLoS ONE

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Scholarly Works

Keyword Analysis

Neurosciences
Clinical Health (organs, Diseases and Abnormal Conditions)
Clinical Sciences
Public Health
Expanding Knowledge
Biochemistry and Cell Biology
Clinical (organs, Diseases and Abnormal Conditions)
Public Health (excl. Specific Population Health)
Other Medical and Health Sciences
Cognitive Sciences

News

Displaying the most recent news article by Ashley Bush.

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‘Rusty’ brains linked to Alzheimer’s

Ashley Bush, Scott Ayton

July 24, 2017

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Honours, Awards and Fellowships

2019

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