Ashley Bush (MBBS, DPM, FRANZCP, PhD, FAAHMS, FAPA), NHMRC Senior Principal Research Fellow is the Director of the Melbourne Dementia Research Centre and Head of the Oxidation Biology Unit at The Florey Institute of Neuroscience & Mental Health, University of Melbourne. He has made outstanding contributions to the neuroscience field, most notably his discovery of the importance of metals and oxidative stress in neurological disease.
The impact of his work has moved the field of neurodegeneration towards an appreciation for an underlying disturbance in brain metal homeostasis, and has provided insights into the pathogenesis of Alzheimer’s disease (AD) as well as other brain diseases including amyotrophic lateral sclerosis, Parkinson’s and Huntington’s diseases. His leadership has led to the development of new predictive tests for AD and innovative, potentially disease-modifying strategies based on his research. He is Chief Scientific Officer for the Cooperative Research Centre for Mental Health (Parkville) and Co-Director of Biomarker Development for The Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL). He is Professor of Neuroscience and Psychiatry at the University of Melbourne, and holds courtesy staff appointments in Psychiatry and Radiology at Massachusetts General Hospital, USA. He is Founding Scientist of Prana Biotechnology Ltd, Cogstate Ltd, and Chief Scientific Officer for Collaborative Medicinal Development P/L. As a recognised expert in his field, Prof Bush has published 455+ publications (>43,600 citations) and 28 patents, is ad hoc reviewer of 52 journals, and has delivered over 320 invited lectures (including 211 international and 26 Plenary). Prof Bush is one of the most highly cited neuroscientists in Australia, is rated in the top 1% of neuroscience researchers worldwide for high impact citations (2014-2016, 2018, 2019), and classed as one of the World's Most Influential Scientific Minds (Thomson Reuters & Clarivate Analytics).
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FEATURED Journal article
Preferential Neurodegeneration in the Dentate Gyrus by Amyloid β1-42-Induced Intracellular Zn2 Dysregulation and Its Defense Strategy.
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Projects
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Project Types
29
Research Grant
3
Research Contracts
1
Internal Research Grant
Scholarly Works
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Honours, Awards and Fellowships
World's Most Influential Scientific Minds
World's Most Influential Scientific Minds
World's Most Influential Scientific Minds
Victoria Prize for Science & Innovation
Schering-Plough Senior Research Award
Award in Neurology
Federation Fellowship
Zenith Fellowship
Potamkin Prize
Senator Mark A. Hatfield Award for Clinical Research in Alzheimer's Disease
Paul Beeson Physician Faculty Scholar in Aging
Ellison Scholarship
Organon Award for Psychiatric Research
Scholars Award