Ashley Bush

Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia-reperfusion damage

Francesca M Alves, Kai Kysenius, Marissa K Caldow, Justin P Hardee, Peter J Crouch, Scott Ayton, Ashley I Bush, Gordon S Lynch, Rene Koopman

Journal article  |  2021  |  Journal of Cachexia Sarcopenia and Muscle

BACKGROUND: Oxidative stress is implicated in the insidious loss of muscle mass and strength that occurs with age. However, few st..

Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE epsilon 4, sex and age

Scott Ayton, Shorena Janelidze, Blaine Roberts, Sebastian Palmqvist, Pawel Kalinowski, Ibrahima Diouf, Abdel A Belaidi, Erik Stomrud, Ashley Bush, Oskar Hansson

Journal article  |  2021  |  Progress in Neurobiology

It is unknown how neuroinflammation may feature in the etiology of Alzheimer's disease (AD). We profiled acute phase response (APR..

Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases

Parsa Ravanfar, Samantha M Loi, Warda T Syeda, Tamsyn E Van Rheenen, Ashley I Bush, Patricia Desmond, Vanessa L Cropley, Darius JR Lane, Carlos M Opazo, Bradford A Moffat, Dennis Velakoulis, Christos Pantelis

Journal article  |  2021  |  Frontiers in Neuroscience

Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In the past decade, development of the new m..

Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease.

James M Roe, Didac Vidal-Piñeiro, Øystein Sørensen, Andreas M Brandmaier, Sandra Düzel, Hector A Gonzalez, Rogier A Kievit, Ethan Knights, Simone Kühn, Ulman Lindenberger, Athanasia M Mowinckel, Lars Nyberg, Denise C Park, Sara Pudas, Melissa M Rundle, Kristine B Walhovd, Anders M Fjell, René Westerhausen, undefined Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing

Journal article  |  2021  |  Nature Communications

Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an orga..

Regional brain iron associated with deterioration in Alzheimer's disease: A large cohort study and theoretical significance.

Scott Ayton, Stuart Portbury, Pawel Kalinowski, Puja Agarwal, Ibrahima Diouf, Julie A Schneider, Martha Clare Morris, Ashley I Bush

Journal article  |  2021  |  Alzheimer's & Dementia

OBJECTIVE: This paper is a proposal for an update of the iron hypothesis of Alzheimer's disease (AD), based on large-scale emergin..

beta-amyloid: The known unknowns

Scott Ayton, Ashley Bush

Journal article  |  2021  |  Ageing Research Reviews

Alzheimer's disease (AD) stands out as a major disease without any form of preventative or disease modifying therapy. This is not ..

Fibrillar alpha-synuclein toxicity depends on functional lysosomes

Stephanie J Guiney, Paul A Adlard, Peng Lei, Celeste H Mawal, Ashley Bush, David Finkelstein, Scott Ayton

Journal article  |  2020  |  Journal of Biological Chemistry

Neurodegeneration in Parkinson's disease (PD) can be recapitulated in animals by administration of α-synuclein pre-formed fibrils ..

Acute phase markers in CSF reveal inflammatory changes in Alzheimer’s disease that are impacted by APOE ε4, sex and age but not pathology

Scott Ayton, Shorena Janelidze, Blaine R Roberts, Sebastian Palmqvist, Pawel Kalinowski, Ibrahima Diouf, Abdel Ali Belaidi, Erik Stomrud, Ashley I Bush, Oskar Hansson

Journal article  |  2020  |  Alzheimer's & Dementia

Identification of concordant plasma lipid signatures in Alzheimer’s disease: Validation between two independent studies of Alzheimer’s disease

Kevin Huynh, Wei Ling Florence Lim, Corey Giles, Kaushala S Jayawardana, Agus Salim, Natalie A Mellett, Alexander Smith, Gavriel Olshansky, Brian G Drew, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor LL Villemagne, David Ames, Colin L Masters, Matthias Arnold, Kwangsik Nho, Andrew J Saykin, et al.

Journal article  |  2020  |  Alzheimer's & Dementia

Deferiprone to delay dementia (the 3D trial)

Scott Ayton, Michael Woodward, Kathryn A Ellis, Yen Ying Lim, Paul T Maruff, Patricia M Desmond, Olivier Salvado, Amir Fazlollahi, Christopher C Rowe, Leonid Churilov, Ashley I Bush

Journal article  |  2020  |  Alzheimer's & Dementia