Ross Vlahos

Ambulatory Oxygen in Fibrotic Interstitial Lung Disease: A Pilot, Randomized, Triple-Blinded, Sham-Controlled Trial.

Yet H Khor, Anne E Holland, Nicole SL Goh, Belinda R Miller, Ross Vlahos, Steven Bozinovski, Aroub Lahham, Ian Glaspole, Christine F McDonald

Journal article  |  2020  |  Chest

BACKGROUND: Despite a lack of evidence, ambulatory oxygen therapy is frequently prescribed for patients with interstitial lung dis..

Excessive Reactive Oxygen Species Inhibit IL-17A( ) gamma delta T Cells and Innate Cellular Responses to Bacterial Lung Infection

Desiree Anthony, Angelica Papanicolaou, Hao Wang, Huei Jiunn Seow, Eunice E To, Selcuk Yatmaz, Gary P Anderson, Odilia Wijburg, Stavros Selemidis, Ross Vlahos, Steven Bozinovski

Journal article  |  2019  |  Antioxidants & Redox Signaling

CSF3R/CD114 mediates infection-dependent transition to severe asthma

Hao Wang, Meaghan FitzPatrick, Nicholas J Wilson, Desiree Anthony, Patrick C Reading, Catherine Satzke, Eileen M Dunne, Paul V Licciardi, Huei Jiunn Seow, Kristy Nichol, Ian M Adcock, Kian Fan Chung, Gary P Anderson, Ross Vlahos, Peter Wark, Steven Bozinovski

Journal article  |  2019  |  Journal of Allergy and Clinical Immunology

Increased hypothalamic microglial activation after viral-induced pneumococcal lung infection is associated with excess serum amyloid A production.

Hao Wang, Melissa Blackall, Luba Sominsky, Sarah J Spencer, Ross Vlahos, Melissa Churchill, Steven Bozinovski

Journal article  |  2018  |  Journal of Neuroinflammation

BACKGROUND: It is well established that lung pathology and inflammation are more severe during respiratory infections complicated ..

E-Cigarettes: Inducing Inflammation that Spans Generations.

Ross Vlahos

Journal article  |  2018  |  American Journal of Respiratory Cell and Molecular Biology

ANTI G-CSFR ANTIBODY TREATMENT SUPPRESSES NEUTROPHILIC AND TYPE-2 LUNG INFLAMMATION IN AN ALLERGIC ASTHMA MODEL WORSENED BY NEONATAL CO-INFECTION

H Wang, M Fitzpatrick, D Anthony, P Reading, N Wilson, C Satzke, E Dunne, P Licciardi, G Anderson, R Vlahos, S Bozinovski

Conference Proceedings  |  2018  |  RESPIROLOGY

Protocols to Evaluate Cigarette Smoke-Induced Lung Inflammation and Pathology in Mice.

Ross Vlahos, Steven Bozinovski

Book Chapter  |  2018  |  Methods in Molecular Biology

Cigarette smoking is a major cause of chronic obstructive pulmonary disease (COPD). Inhalation of cigarette smoke causes inflammat..

Tumour-associated neutrophils and loss of epithelial PTEN can promote corticosteroid-insensitive MMP-9 expression in the chronically inflamed lung microenvironment

Amanda Vannitamby, Huei Jiunn Seow, Gary Anderson, Ross Vlahos, Michelle Thompson, Daniel Steinfort, Louis B Irving, Steven Bozinovski

Journal article  |  2017  |  Thorax

Evaluation of right heart function in a rat model using modified echocardiographic views

Ivan Bernardo, James Wong, Mary E Wlodek, Ross Vlahos, Paul Soeding

Journal article  |  2017  |  PLOS ONE

Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema

Saleela M Ruwanpura, Louise McLeod, Lovisa F Dousha, Huei J Seow, Sultan Alhayyani, Michelle D Tate, Virginie Deswaerte, Gavin D Brooks, Steven Bozinovski, Martin MacDonald, Christoph Garbers, Paul T King, Philip G Bardin, Ross Vlahos, Stefan Rose-John, Gary P Anderson, Brendan J Jenkins

Journal article  |  2016  |  American Journal of Respiratory and Critical Care Medicine

Emerging therapies for the treatment of skeletal muscle wasting in chronic obstructive pulmonary disease

Samantha L Passey, Michelle J Hansen, Steven Bozinovski, Christine F McDonald, Anne E Holland, Ross Vlahos

Journal article  |  2016  |  Pharmacology & Therapeutics

COPD and stroke: are systemic inflammation and oxidative stress the missing links?

Victoria Austin, Peter J Crack, Steven Bozinovski, Alyson A Miller, Ross Vlahos

Journal article  |  2016  |  Clinical Science

Influenza A virus infection and cigarette smoke impair bronchodilator responsiveness to beta-adrenoceptor agonists in mouse lung

Chantal Donovan, Huei Jiunn Seow, Jane E Bourke, Ross Vlahos

Journal article  |  2016  |  Clinical Science

Targeting the IL-33/IL-13 Axis for Respiratory Viral Infections

Chantal Donovan, Jane E Bourke, Ross Vlahos

Journal article  |  2016  |  Trends in Pharmacological Sciences

Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice

LC Oostwoud, P Gunasinghe, HJ Seow, JM Ye, S Selemidis, S Bozinovski, R Vlahos

Journal article  |  2016  |  Scientific Reports

COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link

Steven Bozinovski, Ross Vlahos, Desiree Anthony, Jonathan McQualter, Gary Anderson, Louis Irving, Daniel Steinfort

Journal article  |  2016  |  British Journal of Pharmacology

Serum Amyloid A Induces Toll-Like Receptor 2-Dependent Inflammatory Cytokine Expression and Atrophy in C2C12 Skeletal Muscle Myotubes

Samantha L Passey, Steven Bozinovski, Ross Vlahos, Gary P Anderson, Michelle J Hansen

Journal article  |  2016  |  PLOS ONE

Do anti-viral neutrophil responses exacerbate lung inflammation in asthma?

Ross Vlahos, Steven Bozinovski

Journal article  |  2016  |  Respirology

Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette-smoke-induced lung inflammation in mice

Steven Bozinovski, Huei Jiunn Seow, Sheau Pyng Jamie Chan, Desiree Anthony, Jonathan McQualter, Michelle Hansen, Brendan J Jenkins, Gary P Anderson, Ross Vlahos

Journal article  |  2015  |  Clinical Science

Targeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities

Ivan Bernardo, Steven Bozinovski, Ross Vlahos

Journal article  |  2015  |  Pharmacology & Therapeutics

Alteration of Airway Reactivity and Reduction of Ryanodine Receptor Expression by Cigarette Smoke in Mice

Chantal Donovan, Huei Jiunn Seow, Simon G Royce, Jane E Bourke, Ross Vlahos

Journal article  |  2015  |  American Journal of Respiratory Cell and Molecular Biology

Preclinical murine models of Chronic Obstructive Pulmonary Disease

Ross Vlahos, Steven Bozinovski

Journal article  |  2015  |  European Journal of Pharmacology

Specific Contributions of CSF-1 and GM-CSF to the Dynamics of the Mononuclear Phagocyte System

Cynthia Louis, Andrew D Cook, Derek Lacey, Andrew J Fleetwood, Ross Vlahos, Gary P Anderson, John A Hamilton

Journal article  |  2015  |  The Journal of Immunology

Multifaceted Role for 1L-17A in the Pathogenesis of Chronic Obstructive Pulmonary Disease

Steven Bozinovski, Ross Vlahos

Journal article  |  2015  |  American Journal of Respiratory and Critical Care Medicine

Lipopolysaccharide Does Not Alter Small Airway Reactivity in Mouse Lung Slices

Chantal Donovan, Simon G Royce, Ross Vlahos, Jane E Bourke

Journal article  |  2015  |  PLOS ONE

HSP90 Inhibition Suppresses Lipopolysaccharide-Induced Lung Inflammation In Vivo

Andrew Lilja, Clare E Weeden, Kate McArthur, Nguyen Thao, Alastair Donald, Zi Xin Wong, Lovisa Dousha, Steve Bozinovski, Ross Vlahos, Christopher J Burns, Marie-Liesse Asselin-Labat, Gary P Anderson

Journal article  |  2015  |  PLOS ONE

NADPH Oxidases as Novel Pharmacologic Targets against Influenza A Virus Infection

Ross Vlahos, Stavros Selemidis

Journal article  |  2014  |  Molecular Pharmacology

IL-17A and Serum Amyloid A Are Elevated in a Cigarette Smoke Cessation Model Associated with the Persistence of Pigmented Macrophages, Neutrophils and Activated NK Cells

Michelle J Hansen, Sheau Pyng J Chan, Shenna Y Langenbach, Lovisa F Dousha, Jessica E Jones, Selcuk Yatmaz, Huei Jiunn Seow, Ross Vlahos, Gary P Anderson, Steven Bozinovski

Journal article  |  2014  |  PLoS ONE

Targeting pro-resolution pathways to combat chronic inflammation in COPD

Steven Bozinovski, Desiree Anthony, Ross Vlahos

Journal article  |  2014  |  Journal of Thoracic Disease

Therapeutic potential of Panax ginseng and ginsenosides in the treatment of chronic obstructive pulmonary disease

JL Shergis, YM Di, AL Zhang, R Vlahos, R Helliwell, JM Ye, CC Xue

Journal article  |  2014  |  Complementary Therapies in Medicine

Role of alveolar macrophages in chronic obstructive pulmonary disease

Ross Vlahos, Steven Bozinovski

Journal article  |  2014  |  Frontiers in Immunology

SAA drives proinflammatory heterotypic macrophage differentiation in the lung via CSF-1R-dependent signaling

Desiree Anthony, Jonathan L McQualter, Maria Bishara, Ee X Lim, Selcuk Yatmaz, Huei Jiunn Seow, Michelle Hansen, Michelle Thompson, John A Hamilton, Louis B Irving, Bruce D Levy, Ross Vlahos, Gary P Anderson, Steven Bozinovski

Journal article  |  2014  |  The FASEB Journal

Influenza A virus and TLR7 activation potentiate NOX2 oxidase-dependent ROS production in macrophages

EE To, BRS Broughton, KS Hendricks, R Vlahos, S Selemidis

Journal article  |  2014  |  Free Radical Research

IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice

Saleela M Ruwanpura, Louise McLeod, Gavin D Brooks, Steven Bozinovski, Ross Vlahos, Anthony Longano, Philip G Bardin, Gary P Anderson, Brendan J Jenkins

Journal article  |  2014  |  Respirology

Recent advances in pre-clinical mouse models of COPD

Ross Vlahos, Steven Bozinovski

Journal article  |  2014  |  Clinical Science

Treating neutrophilic inflammation in COPD by targeting ALX/FPR2 resolution pathways

Steven Bozinovski, Desiree Anthony, Gary P Anderson, Louis B Irving, Bruce D Levy, Ross Vlahos

Journal article  |  2013  |  Pharmacology and Therapeutics

The Lung Inflammation and Skeletal Muscle Wasting Induced by Subchronic Cigarette Smoke Exposure Are Not Altered by a High-Fat Diet in Mice

Michelle J Hansen, Hui Chen, Jessica E Jones, Shenna Y Langenbach, Ross Vlahos, Rosa C Gualano, Margaret J Morris, Gary P Anderson

Journal article  |  2013  |  PLoS One

Non-Essential Role for TLR2 and Its Signaling Adaptor Mal/TIRAP in Preserving Normal Lung Architecture in Mice

Saleela M Ruwanpura, Louise McLeod, Andrew R Lilja, Gavin Brooks, Lovisa F Dousha, Huei J Seow, Steven Bozinovski, Ross Vlahos, Paul J Hertzog, Gary P Anderson, Brendan J Jenkins

Journal article  |  2013  |  PLoS One

Serum Amyloid A Promotes Lung Neutrophilia by Increasing IL-17A Levels in the Mucosa and gamma delta T Cells

Desiree Anthony, Huei Jiunn Seow, Mohib Uddin, Michelle Thompson, Lovisa Dousha, Ross Vlahos, Louis B Irving, Bruce D Levy, Gary P Anderson, Steven Bozinovski

Journal article  |  2013  |  American Journal of Respiratory and Critical Care Medicine

Glutathione peroxidase-1 as a novel therapeutic target for COPD

Ross Vlahos, Steven Bozinovski

Journal article  |  2013  |  Redox Report

Nox1 Oxidase Suppresses Influenza A Virus-Induced Lung Inflammation and Oxidative Stress

Stavros Selemidis, Huei Jiunn Seow, Brad RS Broughton, Antony Vinh, Steven Bozinovski, Christopher G Sobey, Grant R Drummond, Ross Vlahos

Journal article  |  2013  |  PLoS One

Glutathione Peroxidase-1 Reduces Influenza A Virus-Induced Lung Inflammation

Selcuk Yatmaz, Huei Jiunn Seow, Rosa C Gualano, Zi Xin Wong, John Stambas, Stavros Selemidis, Peter J Crack, Steven Bozinovski, Gary P Anderson, Ross Vlahos

Journal article  |  2013  |  American Journal of Respiratory Cell and Molecular Biology

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

Robert JJ O'Donoghue, Darryl A Knight, Carl D Richards, Cecilia M Prele, Hui Ling Lau, Andrew G Jarnicki, Jessica Jones, Steven Bozinovski, Ross Vlahos, Stefan Thiem, Brent S McKenzie, Bo Wang, Philip Stumbles, Geoffrey J Laurent, Robin J McAnulty, Stefan Rose-John, Hong Jian Zhu, Gary P Anderson, Matthias R Ernst, Steven E Mutsaers

Journal article  |  2012  |  EMBO Molecular Medicine

Distinct Macrophage Subpopulations Characterize Acute Infection and Chronic Inflammatory Lung Disease

Mubing Duan, Waichu C Li, Ross Vlahos, Mhairi J Maxwell, Gary P Anderson, Margaret L Hibbs

Journal article  |  2012  |  Journal of Immunology

INHIBITION OF NOX1 OXIDASE EXACERBATES INFLUENZA A VIRUS-INDUCED LUNG INFLAMMATION.

Stavros Selemidis, Huei Juinn Seow, Brad Broughton, Steven Bozinovski, Antony Vinh, John Stambas, Christopher Sobey, Grant Drummond, Ross Vlahos

Conference Proceedings  |  2012  |  The FASEB JOURNAL

Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation

Jason C Lenzo, Amanda L Turner, Andrew D Cook, Ross Vlahos, Gary P Anderson, Eric C Reynolds, John A Hamilton

Journal article  |  2012  |  Immunology and Cell Biology

Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice

Saleela M Ruwanpura, Louise McLeod, Alistair Miller, Jessica Jones, Ross Vlahos, Georg Ramm, Anthony Longano, Philip G Bardin, Steven Bozinovski, Gary P Anderson, Brendan J Jenkins

Journal article  |  2012  |  American Journal of Physiology - Lung Cellular and Molecular Physiology

Glucocorticosteroids Differentially Regulate MMP-9 and Neutrophil Elastase in COPD

Ross Vlahos, Peter AB Wark, Gary P Anderson, Steven Bozinovski

Journal article  |  2012  |  PLoS One

Glutathione Peroxidase-1 Primes Pro-Inflammatory Cytokine Production after LPS Challenge In Vivo

Steven Bozinovski, Huei Jiunn Seow, Peter J Crack, Gary P Anderson, Ross Vlahos

Journal article  |  2012  |  PLoS One

Serum amyloid A opposes lipoxin A(4) to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease

Steven Bozinovski, Mohib Uddin, Ross Vlahos, Michelle Thompson, Jonathan L McQualter, Anne-Sophie Merritt, Peter AB Wark, Anastasia Hutchinson, Louis B Irving, Bruce D Levy, Gary P Anderson

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

Serum amyloid A opposes lipoxin A4 to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease

S Bozinovski, undefined Uddin, RV Vlahos, undefined Thompson, JL Mcqualter, undefined Merritt, B Wark, undefined Hutchinson, LB Irving, GP Anderson

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy

Ross Vlahos, John Stambas, Stavros Selemidis

Journal article  |  2012  |  Trends in Pharmacological Sciences

Interleukin-6 Promotes Pulmonary Emphysema Associated with Apoptosis in Mice

Saleela M Ruwanpura, Louise McLeod, Alistair Miller, Jessica Jones, Steven Bozinovski, Ross Vlahos, Matthias Ernst, Jane Armes, Philip G Bardin, Gary P Anderson, Brendan J Jenkins

Journal article  |  2011  |  American Journal of Respiratory Cell and Molecular Biology

Carbonylation Caused by Cigarette Smoke Extract Is Associated with Defective Macrophage Immunity

Steven Bozinovski, Ross Vlahos, Yilin Zhang, Lin Chin Lah, Huei Jiunn Seow, Ashley Mansell, Gary P Anderson

Journal article  |  2011  |  American Journal of Respiratory Cell and Molecular Biology

Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation

Ross Vlahos, John Stambas, Steven Bozinovski, Brad RS Broughton, Grant R Drummond, Stavros Selemidis

Journal article  |  2011  |  PLoS Pathogens

Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice

Chi Duong, Huei Jiunn Seow, Steven Bozinovski, Peter J Crack, Gary P Anderson, Ross Vlahos

Journal article  |  2010  |  American Journal of Physiology - Lung Cellular and Molecular Physiology

Neutralizing Granulocyte/Macrophage Colony-Stimulating Factor Inhibits Cigarette Smoke-induced Lung Inflammation

Ross Vlahos, Steven Bozinovski, Sheau Pyng Jamie Chan, Stefan Ivanov, Anders Linden, John A Hamilton, Gary P Anderson

Journal article  |  2010  |  American Journal of Respiratory and Critical Care Medicine

Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement

Andrew D Cook, Christine M De Nardo, Emma L Braine, Amanda L Turner, Ross Vlahos, Kerrie J Way, S Kaye Beckman, Jason C Lenzo, John A Hamilton

Journal article  |  2010  |  Arthritis Research & Therapy

IL-17-producing T lymphocytes in lung tissue and in the bronchoalveolar space after exposure to endotoxin from Escherichia coli in vivo - effects of anti-inflammatory pharmacotherapy

Olof Prause, Apostolos Bossios, Elin Silverpil, Stefan Ivanov, Steven Bozinovski, Ross Vlahos, Margareta Sjostrand, Gary P Anderson, Anders Linden

Journal article  |  2009  |  Pulmonary Pharmacology and Therapeutics

Long-term cigarette smoke exposure increases uncoupling protein expression but reduces energy intake

Hui Chen, Michelle J Hansen, Jessica E Jones, Ross Vlahos, Gary P Anderson, Margaret J Morris

Journal article  |  2008  |  Brain Research

Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice

Rosa C Gualano, Michelle J Hansen, Ross Vlahos, Jessica E Jones, Ruth A Park-Jones, Georgia Deliyannis, Stephen J Turner, Karen A Duca, Gary P Anderson

Journal article  |  2008  |  Respiratory Research

Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice.

Rosa C Gualano, Michelle J Hansen, Ross Vlahos, Jessica E Jones, Ruth A Park-Jones, Georgia Deliyannis, Stephen J Turner, Karen A Duca, Gary P Anderson

Journal article  |  2008  |  Respiratory Research

BACKGROUND: Cigarette smoke has both pro-inflammatory and immunosuppressive effects. Both active and passive cigarette smoke expos..

Serum amyloid A is a biomarker of acute exacerbations of chronic obstructive pulmonary disease

Steven Bozinovski, Anastasia Hutchinson, Michelle Thompson, Lochlan MacGregor, James Black, Eleni Giannakis, Anne-Sophie Karlsson, Roger Silvestrini, David Smallwood, Ross Vlahos, Louis B Irving, Gary P Anderson

Journal article  |  2008  |  American Journal of Respiratory and Critical Care Medicine

Detrimental metabolic effects of combining long-term cigarette smoke exposure and high-fat diet in mice

Hui Chen, Michelle J Hansen, Jessica E Jones, Ross Vlahos, Gary P Anderson, Margaret J Morris

Journal article  |  2007  |  American Journal of Physiology - Endocrinology and Metabolism

A community-based, time-matched, case-control study of respiratory viruses and exacerbations of COPD

Anastasia F Hutchinson, Anil K Ghimire, Michelle A Thompson, Jim F Black, Caroline A Brand, Adrian J Lowe, David M Smallwood, Ross Vlahos, Steven Bozinovski, Graham V Brown, Gary P Anderson, Louis B Irving

Journal article  |  2007  |  Respiratory Medicine

Functional relevance of the IL-23-IL-17 axis in lungs in vivo

Stefan Ivanov, Steven Bozinovski, Apostolos Bossios, Hadi Valadi, Ross Vlahos, Carina Malmhall, Margareta Sjostrand, Jay K Kolls, Gary P Anderson, Anders Linden

Journal article  |  2007  |  American Journal of Respiratory Cell and Molecular Biology

Regulation of hypothalamic NPY by diet and smoking

Hui Chen, Michelle J Hansen, Jessica E Jones, Ross Vlahos, Steve Bozinovski, Gary P Anderson, Margaret J Morris

Journal article  |  2007  |  Peptides

Therapeutic potential of treating chronic obstructive pulmonary disease (COPD) by neutralising granulocyte macrophage-colony stimulating factor (GM-CSF)

R Vlahos, S Bozinovski, JA Hamilton, GP Anderson

Journal article  |  2006  |  Pharmacology and Therapeutics

Cigarette smoke exposure reprograms the hypothalamic neuropeptide Y axis to promote weight loss

Hui Chen, Michelle J Hansen, Jessica E Jones, Ross Vlahos, Steve Bozinovski, Gary P Anderson, Margaret J Morris

Journal article  |  2006  |  American Journal of Respiratory and Critical Care Medicine

Differential protease, innate immunity, and NF-kappa B induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice

R Vlahos, S Bozinovski, JE Jones, J Powell, J Gras, A Lilja, MJ Hansen, RC Gualano, L Irving, GP Anderson

Journal article  |  2006  |  American Journal of Physiology - Lung Cellular and Molecular Physiology

The effect of tissue type-plasminogen activator deletion and associated fibrin (ogen) deposition on macrophage localization in peritoneal inflammation

AD Cook, R Vlahos, CM Massa, EL Braine, JC Lenzo, AL Turner, KJ Way, JA Hamilton

Journal article  |  2006  |  Thrombosis and Haemostasis

Modelling COPD in mice

R Vlahos, S Bozinovski, RC Gualano, M Ernst, GP Anderson

Journal article  |  2006  |  Pulmonary Pharmacology and Therapeutics

Therapeutic prospects to treat skeletal muscle wasting in COPD (chronic obstructive lung disease)

MJ Hansen, RC Gualano, S Bozinovski, R Vlahos, GP Anderson

Journal article  |  2006  |  Pharmacology and Therapeutics

What is the contribution of respiratory viruses and lung proteases to airway remodelling in asthma and chronic obstructive pulmonary disease?

RC Gualano, R Vlahos, GP Anderson

Journal article  |  2006  |  Pulmonary Pharmacology and Therapeutics

Akt in the pathogenesis of COPD.

Steven Bozinovski, Ross Vlahos, Michelle Hansen, Ken Liu, Gary P Anderson

Journal article  |  2006  |  The International Journal of Chronic Obstructive Pulmonary Disease

In this review we consider the therapeutic potential of targeting Akt for the treatment of COPD. Akt is a serine/threonine protein..

Effect of short-term cigarette smoke exposure on body weight, appetite and brain neuropeptide Y in mice

H Chen, R Vlahos, S Bozinovski, J Jones, GP Anderson, MJ Morris

Journal article  |  2005  |  Neuropsychopharmacology

S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo

S Bozinovski, M Cross, R Vlahos, JE Jones, K Hsuu, PA Tessier, EC Reynolds, DA Hume, JA Hamilton, CL Geczy, GP Anderson

Journal article  |  2005  |  Journal of Proteome Research

Contribution of the p38(MAPK) signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen-specific

DJ Fernandes, CE Ravenhall, T Harris, T Tran, R Vlahos, AG Stewart

Journal article  |  2004  |  British Journal of Pharmacology

Cromakalim inhibits transmitter acetylcholine release in rat trachea by an action on epithelial cells and a diffusible factor

R Vlahos, ME Fabiani, DF Story

Journal article  |  2003  |  Naunyn-Schmiedeberg's Archives of Pharmacology

Differential inhibition of thrombin- and EGF-stimulated human cultured airway smooth muscle proliferation by glucocorticoids

R Vlahos, KS Lee, E Guida, DJ Fernandes, JW Wilson, AG Stewart

Journal article  |  2003  |  Pulmonary Pharmacology and Therapeutics

Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NF kappa B and AP-1 in vivo

S Bozinovski, JE Jones, R Vlahos, JA Hamilton, GP Anderson

Journal article  |  2002  |  Journal of Biological Chemistry

Antigen-induced airway inflammation in the Brown Norway rat results in airway smooth muscle hyperplasia

KF Xu, R Vlahos, A Messina, TL Bamford, JF Bertram, AG Stewart

Journal article  |  2002  |  Journal of Applied Physiology

2-methoxyestradiol and analogs as novel antiproliferative agents: Analysis of three-dimensional quantitative structure-activity relationships for DNA synthesis inhibition and estrogen receptor binding

RA Hughes, T Harris, E Altmann, D McAllister, R Vlahos, A Robertson, M Cushman, ZQ Wang, AG Stewart

Journal article  |  2002  |  Molecular Pharmacology

Oestradiol Metabolites. Effects on Airway Remodelling

A STEWART, R VLAHOS, DJ FERNANDES, RA HUGHES

Book Chapter  |  2001