Nicholas Williamson

The developmental phosphoproteome of Haemonchus contortus.

Tao Wang, Guangxu Ma, Ching-Seng Ang, Pasi K Korhonen, Andreas J Stroehlein, Neil D Young, Andreas Hofmann, Bill CH Chang, Nicholas A Williamson, Robin B Gasser

Journal article  |  2020  |  Journal of Proteomics

Protein phosphorylation plays essential roles in many cellular processes. Despite recent progress in the genomics, transcriptomics..

Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury

Prue M Pereira-Fantini, Boyuan Pang, Sean G Byars, Regina B Oakley, Elizabeth J Perkins, Peter A Dargaville, Peter G Davis, Shuai Nie, Nicholas A Williamson, Vera Ignjatovic, David G Tingay

Journal article  |  2019  |  American Journal of Respiratory Cell and Molecular Biology

The development of regional lung injury in the preterm lung is not well understood. This study aimed to characterize time-dependen..

IgE-reactive proteins defined by 88 fish-allergic children, predicting the allergenicity of 66 Asia-Pacific fish species

T Ruethers, AC Taki, R Nugraha, S Karnaneedi, TT Cao, D Dai, T Shanmuganathan, M Leeming, S Nie, NA Williamson, SS Mehr, DE Campbell, AL Lopata

Conference Proceedings  |  2019  |  ALLERGY

High throughput LC-MS/MS-based proteomic analysis of excretory-secretory products from short-term in vitro culture of Haemonchus contortus

Tao Wang, Guangxu Ma, Ching-Seng Ang, Pasi K Korhonen, Anson Koehler, Neil D Young, Shuai Nie, Nicholas A Williamson, Robin B Gasser

Journal article  |  2019  |  Journal of Proteomics

Parasitic nematodes of humans, animals and plants have a major, adverse impact on global health and agricultural production worldw..

Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism

Guangxu Ma, Tao Wang, Pasi K Korhonen, Neil D Young, Shuai Nie, Ching-Seng Ang, Nicholas A Williamson, Gavin E Reid, Robin B Gasser

Journal article  |  2019  |  PLOS Pathogens

Here, we discovered an endogenous dafachronic acid (DA) in the socioeconomically important parasitic nematode Haemonchus contortus..

Quantitative proteomic analyses of dynamic signalling events associated with neuronal death in excitotoxicity

MA Hoque, Nicholas A Williamson, C-S Ang, JS Oakhill, H-C Cheng

Conference Proceedings  |  2019  |  JOURNAL OF NEUROCHEMISTRY

Variability of allergens in commercial fish extracts for skin prick testing

Thimo Ruethers, Aya C Taki, Roni Nugraha, T Cao Truc, Martina Koeberl, Sandip D Kannath, Nicholas A Williamson, Sean O'Callaghan, Shuai Nie, Sam S Mehr, Dianne E Cannpbell, Andreas L Lopata

Journal article  |  2019  |  Allergy

BACKGROUND: Commercial allergen extracts for allergy skin prick testing (SPT) are widely used for diagnosing fish allergy. However..

Developmental lipidome and proteome of Haemonchus contortus reflect unique adaptations in the transition to parasitism

S Nie, Tao Wang, Guangxu Ma, Ching-Seng Ang, Pasi Korhonen, Rong Xu, Anson Koehler, Richard SIMPSON, David GREENING, Gavin Reid, Nicholas Williamson, Robin Gasser

Conference Proceedings  |  2019

There has been a dearth of lipidomic and proteomic data sets to underpin fundamental investigations of parasites and parasitism at..

Somatic proteome of Haemonchus contortus

Tao Wang, Guangxu Ma, Ching-Seng Ang, Pasi K Korhonen, Rong Xu, Shuai Nie, Anson V Koehler, Richard J Simpson, David W Greening, Gavin E Reid, Nicholas A Williamson, Robin B Gasser

Journal article  |  2019  |  International Journal for Parasitology

Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

Ashfaqul Hoque, Nicholas A Williamson, S Sadia Ameen, Giuseppe D Ciccotosto, M Iqbal Hossain, Jonathan S Oakhill, Dominic CH Ng, Ching-Seng Ang, Heung-Chin Cheng

Journal article  |  2019  |  Cell Death & Disease

Intersectin-1 interacts with the golgin GCC88 to couple the actin network and Golgi architecture

Christian Makhoul, Prajakta Gosavi, Regina Duffield, Bronwen Delbridge, Nicholas A Williamson, Paul A Gleeson

Journal article  |  2019  |  Molecular Biology of the Cell

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells

Sunyuan Zhang, Nicholas A Williamson, Marie A Bogoyevitch

Journal article  |  2018  |  Scientific Data

The developmental lipidome of Haemonchus contortus

Tao Wang, Shuai Nie, Guangxu Ma, Pasi K Korhonen, Anson V Koehler, Ching-Seng Ang, Gavin E Reid, Nicholas A Williamson, Robin B Gasser

Journal article  |  2018  |  International Journal for Parasitology

The risk of shark meat consumption for fish allergy patients and the implication of parvalbumin cross-reactivity

AC Taki, T Ruethers, R Nugraha, NA Williamson, J Stephen, SS Mehr, PA Ramsland, DE Campbell, AL Lopata

Conference Proceedings  |  2018  |  ALLERGY

Molecular alterations during larval development of Haemonchus contortus in vitro are under tight post-transcriptional control

Guangxu Ma, Tao Wang, Pasi K Korhonen, Ching-Seng Ang, Nicholas A Williamson, Neil D Young, Andreas J Stroehlein, Ross S Hall, Anson V Koehler, Andreas Hofmann, Robin B Gasser

Journal article  |  2018  |  International Journal for Parasitology

Operational Experience of an Open-Access, Subscription-Based Mass Spectrometry and Proteomics Facility

Nicholas A Williamson

Journal article  |  2018  |  Journal of The American Society for Mass Spectrometry

Biologically active constituents of the secretome of human W8B2( ) cardiac stem cells

Shuai Nie, Xin Wang, Priyadharshini Sivakumaran, Mark MW Chong, Xin Liu, Tara Karnezis, Nadeeka Bandara, Kaloyan Takov, Cameron J Nowell, Stephen Wilcox, Mitch Shambrook, Andrew F Hill, Nicole C Harris, Andrew E Newcomb, Padraig Strappe, Ramin Shayan, Damian Hernandez, Jordan Clarke, Eric Hanssen, Sean M Davidson, et al.

Journal article  |  2018  |  Scientific Reports

Biologically active composition of human W8B2( ) cardiac stem cell secretome

P Sivakumaran, S Nie, X Wang, T Karnezis, N Bandara, C Nowell, S Wilcox, AF Hill, M Shambrook, NC Harris, AE Newcomb, P Strappe, R Shayan, D Hernandez, J Clarke, GJ Dusting, K Takov, S Davidson, E Hanssen, A Pebay, et al.

Conference Proceedings  |  2017  |  HUMAN GENE THERAPY

The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD)

Nichollas E Scott, Cristina Giogha, Georgina L Pollock, Catherine L Kennedy, Andrew I Webb, Nicholas A Williamson, Jaclyn S Pearson, Elizabeth L Hartland

Journal article  |  2017  |  Journal of Biological Chemistry

Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development

Molly Parkyn Schneider, Boyin Liu, Philipp Glock, Annika Suttie, Emma McHugh, Dean Andrew, Steven Batinovic, Nicholas Williamson, Eric Hanssen, Paul McMillan, Marion Hliscs, Leann Tilley, Matthew WA Dixon

Journal article  |  2017  |  PLOS Pathogens

A proteomic characterization shows differences in the milk fat globule membrane of buffalo and bovine milk

Hanh TH Nguyen, Lydia Ong, Ashfaqul Hoque, Sandra E Kentish, Nicholas Williamson, Ching-Seng Ang, Sally L Gras

Journal article  |  2017  |  Food Bioscience

Skin prick test preparations for seafood allergy: a molecular and immunological assessment

T Ruethers, AC Taki, R Nugraha, SD Kamath, EB Johnston, NA Williamson, C Ang, R O'Hehir, S Mehr, DE Campbell, AL Lopata

Conference Proceedings  |  2017  |  ALLERGY

A rigorous method to enrich for exosomes from brain tissue

Laura J Vella, Benjamin J Scicluna, Lesley Cheng, Emma G Bawden, Colin L Masters, Ching-Seng Ang, Nicholas Willamson, Catriona McLean, Kevin J Barnham, Andrew F Hill

Journal article  |  2017  |  Journal of Extracellular Vesicles

Interferon-gamma as a potential biomarker for the inflammation associated with dry eye disease

L DOWNIE, W Zeng, E Mifsud, C Wong, N Williamson, C Ang, A Vingrys, D Jackson

Conference Proceedings  |  2016  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Tear Interferon-Gamma as a Biomarker for Evaporative Dry Eye Disease

David Charles Jackson, Weiguang Zeng, Chinn Yi Wong, Edin Jessica Mifsud, Nicholas Andrew Williamson, Ching-Seng Ang, Algis Jonas Vingrys, Laura Elizabeth Downie

Journal article  |  2016  |  Investigative Opthalmology & Visual Science

Interferon-gamma as a potential biomarker for the inflammation associated with dry eye disease

Laura Elizabeth Downie, Weiguang Zeng, Edin Mifsud, Chinn Yi Wong, Nicholas Williamson, Ching-Seng Ang, Algis J Vingrys, David Jackson

Conference Proceedings  |  2016  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Changes in the Cytoplasmic Composition of Amino Acids and Proteins Observed in Staphylococcus aureus during Growth under Variable Growth Conditions Representative of the Human Wound Site

Mousa M Alreshidi, R Hugh Dunstan, Johan Gottfries, Margaret M Macdonald, Marcus J Crompton, Ching-Seng Ang, Nicholas A Williamson, Tim K Roberts

Journal article  |  2016  |  PLOS ONE

A beacon of hope in stroke therapy Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies

Ashfaqul Hoque, M Iqbal Hossain, S Sadia Ameen, Ching-Seng Ang, Nicholas Williamson, Dominic CH Ng, Anderly C Chueh, Carli Roulston, Heung-Chin Cheng

Journal article  |  2016  |  Pharmacology & Therapeutics

Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation

Nicholas R Lim, Yvonne YC Yeap, Ching-Seng Ang, Nicholas A Williamson, Marie A Bogoyevitch, Leonie M Quinn, Dominic CH Ng

Journal article  |  2016  |  Cell Cycle

T-cell antigen formed from distinct metabolic pathways

Jeffrey Mak, Alexandra Corbett, Sidonia Eckle, Richard Birkinshaw, Ligong Liu, Onisha Patel, Jennifer Mahony, Zhenjun Chen, Rangsima Reantragoon, Bronwyn Meehan, Hanwei Cao, Nicholas Williamson, Richard Strugnell, Douwe Van Sinderen, David Fairlie, Lars Kjer-Nielsen, Jamie Rossjohn, James McCluskey

Conference Proceedings  |  2015  |  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

FunRich: An open access standalone functional enrichment and interaction network analysis tool

Mohashin Pathan, Shivakumar Keerthikumar, Ching-Seng Ang, Lahiru Gangoda, Camelia YJ Quek, Nicholas A Williamson, Dmitri Mouradov, Oliver M Sieber, Richard J Simpson, Agus Salim, Antony Bacic, Andrew F Hill, David A Stroud, Michael T Ryan, Johnson I Agbinya, John M Mariadason, Antony W Burgess, Suresh Mathivanan

Journal article  |  2015  |  PROTEOMICS

Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules

Nicholas R Lim, Yvonne YC Yeap, Teresa T Zhao, Yan Y Yip, Shu C Wong, Dan Xu, Ching-Seng Ang, Nicholas A Williamson, Zhiheng Xu, Marie A Bogoyevitch, Dominic CH Ng

Journal article  |  2015  |  Journal of Cell Science

Pancreatic Beta Cells Are Highly Susceptible to Oxidative and ER Stresses during the Development of Diabetes

Dhana G Gorasia, Nadine L Dudek, Paul D Veith, Renu Shankar, Helena Safavi-Hemami, Nicholas A Williamson, Eric C Reynolds, Michael J Hubbard, Anthony W Purcell

Journal article  |  2015  |  Journal of Proteome Research

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases. (vol 281, pg 32988, 2006)

Yuh-Ping Chong, Andrew S Chan, Khai-Chew Chan, Nicholas A Williamson, Edwina C Lerner, Thomas E Smithgall, Jeffrey D Bjorge, Donald J Fujita, Anthony W Purcell, Glen Scholz, Terrence D Mulhern, Heung-Chin Cheng

Journal article  |  2015  |  Journal of Biological Chemistry

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

Alexandra J Corbett, Sidonia BG Eckle, Richard W Birkinshaw, Ligong Liu, Onisha Patel, Jennifer Mahony, Zhenjun Chen, Rangsima Reantragoon, Bronwyn Meehan, Hanwei Cao, Nicholas A Williamson, Richard A Strugnell, Douwe Van Sinderen, Jeffrey YW Mak, David P Fairlie, Lars Kjer-Nielsen, Jamie Rossjohn, James McCluskey

Journal article  |  2014  |  Nature

A type III effector antagonizes death receptor signalling during bacterial gut infection

Jaclyn S Pearson, Cristina Giogha, Sze Ying Ong, Catherine L Kennedy, Michelle Kelly, Keith S Robinson, Tania Wong Fok Lung, Ashley Mansell, Patrice Riedmaier, Clare VL Oates, Ali Zaid, Sabrina Muehlen, Valerie F Crepin, Olivier Marches, Ching-Seng Ang, Nicholas A Williamson, Lorraine A O'Reilly, Aleksandra Bankovacki, Ueli Nachbur, Giuseppe Infusini, et al.

Journal article  |  2013  |  Nature

Species differences in the neuromuscular activity of post-synaptic neurotoxins from two Australian black snakes (Pseudechis porphyriacus and Pseudechis colletti)

Andrew J Hart, Geoffrey K Isbister, Paul O'Donnell, Nicholas A Williamson, Wayne C Hodgson

Journal article  |  2013  |  Toxicology Letters

A Truncated Fragment of Src Protein Kinase Generated by Calpain-mediated Cleavage Is a Mediator of Neuronal Death in Excitotoxicity

M Iqbal Hossain, Carli L Roulston, M Aizuddin Kamaruddin, Percy WY Chu, Dominic CH Ng, Gregory J Dusting, Jeffrey D Bjorge, Nicholas A Williamson, Donald J Fujita, Steve N Cheung, Tung O Chan, Andrew F Hill, Heung-Chin Cheng

Journal article  |  2013  |  Journal of Biological Chemistry

MR1 presents microbial vitamin B metabolites to MAIT cells

Lars Kjer-Nielsen, Onisha Patel, Alexandra J Corbett, Jerome Le Nours, Bronwyn Meehan, Ligong Liu, Mugdha Bhati, Zhenjun Chen, Lyudmila Kostenko, Rangsima Reantragoon, Nicholas A Williamson, Anthony W Purcell, Nadine L Dudek, Malcolm J McConville, Richard AJ O'Hair, George N Khairallah, Dale I Godfrey, David P Fairlie, Jamie Rossjohn, James McCluskey

Journal article  |  2012  |  Nature

Modulation of Conotoxin Structure and Function Is Achieved through a Multienzyme Complex in the Venom Glands of Cone Snails

Helena Safavi-Hemami, Dhana G Gorasia, Andrew M Steiner, Nicholas A Williamson, John A Karas, Joanna Gajewiak, Baldomero M Olivera, Grzegorz Bulaj, Anthony W Purcell

Journal article  |  2012  |  Journal of Biological Chemistry

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

Patricia T Illing, Julian P Vivian, Nadine L Dudek, Lyudmila Kostenko, Zhenjun Chen, Mandvi Bharadwaj, John J Miles, Lars Kjer-Nielsen, Stephanie Gras, Nicholas A Williamson, Scott R Burrows, Anthony W Purcell, Jamie Rossjohn, James McCluskey

Journal article  |  2012  |  Nature

Secreted HLA recapitulates the immunopeptidome and allows in-depth coverage of HLA A*02:01 ligands

Katherine E Scull, Nadine L Dudek, Alexandra J Corbett, H Ramarathinam, Dhana G Gorasia, Nicholas A Williamson, Anthony W Purcell

Journal article  |  2012  |  Molecular Immunology

Specialisation of the Venom Gland Proteome in Predatory Cone Snails Reveals Functional Diversification of the Conotoxin Biosynthetic Pathway

Helena Safavi-Hemami, William A Siero, Dhana G Gorasia, Neil D Young, David MacMillan, Nicholas A Williamson, Anthony W Purcell

Journal article  |  2011  |  Journal of Proteome Research

Defining the Substrate Specificity Determinants Recognized by the Active Site of C-Terminal Src Kinase-Homologous Kinase (CHK) and Identification of beta-Synuclein as a Potential CHK Physiological Substrate

Kim K Ia, Grace R Jeschke, Yang Deng, Mohd Aizuddin Kamaruddin, Nicholas A Williamson, Denis B Scanlon, Janetta G Culvenor, Mohammed Iqbal Hossain, Anthony W Purcell, Sheng Liu, Hong-Jian Zhu, Bruno Catimel, Benjamin E Turk, Heung-Chin Cheng

Journal article  |  2011  |  Biochemistry

Direct quantitation of MHC-bound peptide epitopes by selected reaction monitoring

Chor Teck Tan, Nathan P Croft, Nadine L Dudek, Nicholas A Williamson, Anthony W Purcell

Journal article  |  2011  |  Proteomics

Stable isotope shifted matrices enable the use of low mass ion precursor scanning for targeted metabolite identification

Charles B Reilly, Sri H Ramarathinam, Nicholas A Williamson, Anthony W Purcell

Journal article  |  2011  |  Proteome Science

Embryonic Toxin Expression in the Cone Snail Conus victoriae PRIMED TO KILL OR DIVERGENT FUNCTION?

Helena Safavi-Hemami, William A Siero, Zhihe Kuang, Nicholas A Williamson, John A Karas, Louise R Page, David MacMillan, Brid Callaghan, Shiva Nag Kompella, David J Adams, Raymond S Norton, Anthony W Purcell

Journal article  |  2011  |  Journal of Biological Chemistry

Predatory marine cone snails (genus Conus) utilize complex venoms mainly composed of small peptide toxins that target voltage- and..

A novel strategy for the targeted analysis of protein and peptide metabolites

Nicholas A Williamson, Charles Reilly, Chor-Teck Tan, Sri-Harsha Ramarathinam, Alun Jones, Christie L Hunter, Francis R Rooney, Anthony W Purcell

Journal article  |  2011  |  Proteomics

Proteomic Interrogation of Venom Delivery in Marine Cone Snails: Novel Insights into the Role of the Venom Bulb

Helena Safavi-Hemami, Neil D Young, Nicholas A Williamson, Anthony W Purcell

Journal article  |  2010  |  Journal of Proteome Research

Identification of Conus Peptidylprolyl Cis-Trans Isomerases (PPIases) and Assessment of Their Role in the Oxidative Folding of Conotoxins

Helena Safavi-Hemami, Grzegorz Bulaj, Baldomero M Olivera, Nicholas A Williamson, Anthony W Purcell

Journal article  |  2010  |  Journal of Biological Chemistry

Constraints within major histocompatibility complex class I restricted peptides: Presentation and consequences for T-cell recognition

Alex Theodossis, Carole Guillonneau, Andrew Welland, Lauren K Ely, Craig S Clements, Nicholas A Williamson, Andrew I Webb, Jacqueline A Wilce, Roger J Mulder, Michelle A Dunstone, Peter C Doherty, James McCluskey, Anthony W Purcell, Stephen J Turner, Jamie Rossjohn

Journal article  |  2010  |  Proceedings of the National Academy of Sciences of the United States of America

Molecular Markers of Preterm Labor in the Choriodecidua

Renu Shankar, Matthew P Johnson, Nicholas A Williamson, Fiona Cullinane, Anthony W Purcell, Eric K Moses, Shaun P Brennecke

Journal article  |  2010  |  Reproductive Sciences

A Modular BAM Complex in the Outer Membrane of the alpha-Proteobacterium Caulobacter crescentus

Khatira Anwari, Sebastian Poggio, Andrew Perry, Xenia Gatsos, Sri Harsha Ramarathinam, Nicholas A Williamson, Nicholas Noinaj, Susan Buchanan, Kipros Gabriel, Anthony W Purcell, Christine Jacobs-Wagner, Trevor Lithgow

Journal article  |  2010  |  PLoS One

Mass Spectral Identification of Vc1.1 and Differential Distribution of Conopeptides in the Venom Duct of Conus victoriae. Effect of Post-Translational Modifications and Disulfide Isomerisation on Bioactivity

A Townsend, BG Livett, J-P Bingham, H-T Truong, JA Karas, P O'Donnell, NA Williamson, AW Purcell, D Scanlon

Journal article  |  2009  |  International Journal of Peptide Research and Therapeutics

The A-chain of insulin is a hot-spot for CD4( ) T cell epitopes in human type 1 diabetes

SI Mannering, SH Pang, NA Williamson, G Naselli, EC Reynolds, NM O'Brien-Simpson, AW Purcell, LC Harrison

Journal article  |  2009  |  Clinical and Experimental Immunology

Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes

Jan Petersen, Stephanie J Wurzbacher, Nicholas A Williamson, Sri H Ramarathinam, Hugh H Reid, Ashish KN Nair, Anne Y Zhao, Roza Nastovska, Geordie Rudge, Jamie Rossjohn, Anthony W Purcell

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

Refinement in the production and purification of recombinant HCMV IE1-pp65 protein for the generation of epitope-specific T cell immunity

Thi HO Nguyen, Nicole A Mifsud, Lisbeth A Stewart, Mingus J Rose, Tamara L Etto, Nicholas A Williamson, Anthony W Purcell, Tom Kotsimbos, Anthony P Schwarer

Journal article  |  2008  |  Protein Expression and Purification

Human leukocyte antigen class I-restricted activation of CD8( ) T cells provides the immunogenetic basis of a systemic drug hypersensitivity (vol 28, pg 822, 2008)

Diana Chessman, Lyudmila Kostenko, Tessa Lethborg, Anthony W Purcell, Nicholas A Williamson, Zhenjun Chen, Lars Kjer-Nielsen, Nicole A Mifsud, Brian D Tait, Rhonda Holdsworth, Coral Ann Almeida, David Nolan, Whitney A Macdonald, Julia K Archbold, Anthony D Kellerher, Debbie Marriott, Simon Mallal, Mandvi Bharadwaj, Jamie Rossjohn, James McCluskey

Journal article  |  2008  |  Immunity

Human leukocyte antigen class I-restricted activation of CD8( ) T cells provides the immunogenetic basis of a systemic drug hypersensitivity

Diana Chessman, Lyudmila Kostenko, Tessa Lethborg, Anthony W Purcell, Nicholas A Williamson, Zhenjun Chen, Lars Kjer-Nielsen, Nicole A Mifsud, Brian D Tait, Rhonda Holdsworth, Coral Ann Almeida, David Nolan, Whitney A Macdonalds, Julia K Archbold, Anthony D Kellerher, Debbie Marriott, Simon Mallal, Mandvi Bharadwaj, Jamie Rossjohn, James McCluskey

Journal article  |  2008  |  Immunity

The molecular basis of cross-reactivity in the Australian snake venom detection kit (SVDK)

J Steuten, K Winkel, T Carroll, NA Williamson, V Ignjatovic, K Fung, AW Purcell, BG Fry

Journal article  |  2007  |  Toxicon

Expression and purification of the minor histocompatibility antigen, HA-1H generated in Escherichia coli

Tamara L Etto, Lisbeth A Stewart, Thi HO Nguyen, Nicholas A Williamson, Anthony W Purcell, Anthony P Schwarer

Journal article  |  2007  |  Protein Expression and Purification

T-cell receptor deformation of a bulged antigenic peptide enables MHC restricted recognition

FE Tynan, HH Reid, L Kjer-Nielsen, JJ Miles, MCJ Wilce, L Kostenko, NA Borg, NA Williamson, AW Purcell, SR Burrows, J McCluskey, J Rossjohn

Conference Proceedings  |  2007  |  TISSUE ANTIGENS

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

Fleur E Tynan, Hugh H Reid, Lars Kjer-Nielsen, John J Miles, Matthew CJ Wilce, Lyudmila Kostenko, Natalie A Borg, Nicholas A Williamson, Travis Beddoe, Anthony W Purcell, Scott R Burrows, James McCluskey, Jamie Rossjohn

Journal article  |  2007  |  Nature Immunology

Mass spectrometric applications in immunoproteomics

AW Purcell, NA Williamson, AI Webb, K Lau

Book Chapter  |  2007

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases

Yuh-Ping Chong, Andrew S Chan, Khai-Chew Chan, Nicholas A Williamson, Edwina C Lerner, Thomas E Smithgall, Jeffrey D Bjorge, Donald J Fujita, Anthony W Purcell, Glen Scholz, Terrence D Mulhern, Heung-Chin Cheng

Journal article  |  2006  |  Journal of Biological Chemistry

Tumors reveal their secrets to cytotoxic T cells

Nicholas A Williamson, Jamie Rossjohn, Anthony W Purcell

Journal article  |  2006  |  Proceedings of the National Academy of Sciences of the United States of America

A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition

L Kjer-Nielsen, NA Borg, DG Pellicci, T Beddoe, L Kostenko, CS Clements, NA Williamson, MJ Smyth, GS Besra, HH Reid, M Bharadwaj, DI Godfrey, J Rossjohn, J McCluskey

Journal article  |  2006  |  Journal of Experimental Medicine

An enigmatic human CD4 T-cell epitope in the C-peptide of proinsulin.

Stuart Mannering, Daniel Thearle, Kent Jensen, Nicholas Williamson, Anthony Purcell, Leonard Harrison

Conference Proceedings  |  2006  |  Clinical Immunology

Patent protects post-translationally modified insulin epitopes and their use as diagnostics or therapeutics

LC Harrison, SI Mannering, A PURCELL, N WILLIAMSON

Patent  |  2006

Exploiting information inherent in binding sites of virus-specific antibodies: design of an HCV vaccine candidate cross-reactive with multiple genotypes

Lara Grollo, Joseph Torresi, Heidi Drummer, Weiquang Zeng, Nicholas Williamson, David C Jackson

Journal article  |  2006  |  Antiviral Therapy

The insulin A-chain epitope recognized by human T cells is posttranslationally modified

SI Mannering, LC Harrison, NA Williamson, JS Morris, DJ Thearle, KP Jensen, TWH Kay, J Rossjohn, BA Falk, GT Nepom, AW Purcell

Journal article  |  2005  |  Journal of Experimental Medicine

The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

FE Tynan, D Elhassen, AW Purcell, JM Burrows, NA Borg, JJ Miles, NA Williamson, KJ Green, J Tellam, L Kjer-Nielsen, J McCluskey, J Rossjohn, SR Burrows

Journal article  |  2005  |  Journal of Experimental Medicine

The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

SR Burrows, F Tynan, D Elhassen, AW Purcell, NA Borg, JJ Miles, NA Williamson, J McCluskey, J Rossjohn

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

Post-translationally modification - Does the immune system really care?

AW Purcell, K Lau, NA Williamson, AI Webb, LJ Roberts, SI Mannering, LC Harrison

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

T cell determinants incorporating beta-amino acid residues are protease resistant and remain immunogenic in vivo

AI Webb, MA Dunstone, NA Williamson, JD Price, A de Kauwe, WS Chen, A Oakley, P Perlmutter, J McCluskey, MI Aguilar, J Rossjohn, AW Purcell

Journal article  |  2005  |  Journal of Immunology

Modulation of alpha-synuclein aggregation

R Cappai, S Leck, DJ Tew, NA Williamson, DP Smith, D Galatis, RA Sharples, CC Curtain, FE Ali, RA Cherny, JG Culvenor, SP Bottomley, CL Masters, KJ Barnham, AF Hill

Conference Proceedings  |  2005  |  JOURNAL OF NEUROCHEMISTRY

Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

Roberto Cappai, Su-Ling Leck, Deborah J Tew, Nicholas A Williamson, David P Smith, Denise Galatis, Robyn A Sharples, Cyril C Curtain, Feda E Ali, Robert A Cherny, Janetta G Culvenor, Stephen P Bottomley, Colin L Masters, Kevin J Barnham, Andrew F Hill

Journal article  |  2005  |  FASEB Journal

Use of proteomics to define targets of T-cell immunity

NA Williamson, AW Purcell

Journal article  |  2005  |  Expert Review in Proteomics

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

R Cappai, SL Leck, DJ Tew, NA Williamson, DP Smith, D Galatis, RA Sharples, CC Curtain, FE Ali, RA Cherny, JG Culvenor, SP Bottomley, CL Masters, KJ Barnham, AF Hill

Journal article  |  2005  |  FASEB Journal

Interaction of the molecular chaperone alpha B-crystallin with alpha-synuclein: Effects on amyloid fibril formation and chaperone activity

A Rekas, CG Adda, JA Aquilina, KJ Barnham, M Sunde, D Galatis, NA Williamson, CL Masters, RF Anders, CV Robinson, R Cappai, JA Carver

Journal article  |  2004  |  Journal of Molecular Biology

Structural and functional analysis of the Alzheimer's disease amyloid precursor protein copper binding domain

R Cappai, G Kong, W McKinstry, D Galatis, J Adams, S Bellingham, J Camakaris, C Curtain, N Williamson, A White

Conference Proceedings  |  2004  |  Neurobiology of Aging

Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations

JG Culvenor, NT Ilaya, MT Ryan, L Canterford, DE Hoke, NA Williamson, CA McLean, CL Masters, G Evin

Journal article  |  2004  |  European Journal of Biochemistry

Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: Effect of C-terminal truncation on production of beta-amyloid protein

J Nunan, NA Williamson, AF Hill, MF Sernee, CL Masters, DH Small

Journal article  |  2003  |  Journal of Neuroscience Research

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

KJ Barnham, GD Ciccotosto, AK Tickler, FE Ali, DG Smith, NA Williamson, YH Lam, D Carrington, D Tew, G Kocak, I Volitakis, F Separovic, CJ Barrow, JD Wade, CL Masters, RA Cherny, CC Curtain, AI Bush, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

KJ Barnham, WJ McKinstry, G Multhaup, D Galatis, CJ Morton, CC Curtain, NA Williamson, AR White, MG Hinds, RS Norton, K Beyreuther, CL Masters, MW Parker, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain - A regulator of neuronal copper homeostasis

KJ Barnham, WJ McKinstry, G Multhaup, D Galatis, CJ Morton, CC Curtain, NA Williamson, AR White, MG Hinds, RS Norton, K Beyreuther, CL Masters, MW Parker, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.

G EVIN, undefined Sernee, K BARNHAM, undefined Holsinger, J CULVENOR, D HOKE, Q LI, undefined Smith, C MAYNARD, N WILLIAMSON, G CICCOTOSTO, S MOK, I VOLITAKIS, G KOCAK, undefined Carrington, undefined Opazo, AK TICKLER, undefined Huang, undefined Beyreuther, R CAPPAI, et al.

Book Chapter  |  2003

Structure-function of the amyloid precursor protein copper-binding domain

R Cappai, K Barnham, N Williamson, C Masters, W McKinstry, D Galatis, C Curtain, M Parker, G Multhaup, K Beyreuther, A White, M Hinds, R Norton

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

Proteasome-dependent processing of the C-terminal fragment of the amyloid protein precursor alters the production of A beta

J Nunan, NA Williamson, R Cappai, CL Masters, DH Small, MS Shearman, K Beyreuther

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

Reduction of chronic aggressive behaviour 10 years after brain injury

C Watson, NA Rutterford, D Shortland, N Williamson, N Alderman

Journal article  |  2001  |  Brain Injury

Modulation of the catalytic activity of the Src family tyrosine kinase Hck by autophosphorylation at a novel site in the unique domain

TM Johnson, NA Williamson, G Scholz, A Jaworowski, REH Wettenhall, AR Dunn, HC Cheng

Journal article  |  2000  |  Journal of Biological Chemistry

Dual requirement for a newly identified phosphorylation site in p70(s6k)

BA Moser, PB Dennis, N Pullen, RB Pearson, NA Williamson, REH Wettenhall, SC Kozma, G Thomas

Journal article  |  1997  |  Molecular and Cellular Biology

Post-translational processing of rat ribosomal proteins - Ubiquitous methylation of Lys22 within the zinc-finger motif of RL40 (carboxy-terminal extension protein 52) and tissue-specific methylation of Lys4 in RL29

NA Williamson, J Raliegh, NA Morrice, REH Wettenhall

Journal article  |  1997  |  European Journal of Biochemistry

The yeast homolog of mammalian ribosomal protein S30 is expressed from a duplicated gene without a ubiquitin-like protein fusion sequence - Evolutionary implications

RT Baker, NA Williamson, REH Wettenhall

Journal article  |  1996  |  Journal of Biological Chemistry

THE PRINCIPAL TARGET OF RAPAMYCIN-INDUCED P70(S6K) INACTIVATION IS A NOVEL PHOSPHORYLATION SITE WITHIN A CONSERVED HYDROPHOBIC DOMAIN

RB PEARSON, PB DENNIS, JW HAN, NA WILLIAMSON, SC KOZMA, REH WETTENHALL, G THOMAS

Journal article  |  1995  |  The EMBO Journal