Dr Michael Duffy did his PhD in Mycoplasma pneumoniae at the School of Veterinary Science at the University of Melbourne. This basic research identified a species-specific, immunodominant surface antigen that he developed into a serodiagnostic for atypical pneumonia currently produced under licence by a commercial company.
He then undertook post-doctoral research into the malaria parasite Plasmodium falciparum for the Walter and Eliza Hall Institute, but based at the Eijkman Institute in Jakarta Indonesia. He returned to University of Melbourne where his research continued into the highly variable P. falciparum proteins expressed on the infected red blood cell surface in malaria. This work contributed to the identification and characterisation of a parasite protein responsible for malaria during pregnancy. Currently he is investigating parasite proteins responsible for severe malaria that might be exploited in vaccine development. In parallel he has investigated how elements of chromatin structure regulate gene expression in P. falciparum. This work developed through his study of the epigenetic control of antigenic variation in P. falciparum and has diversified into the broader study of unique chromatin proteins in P. falciparum, including variant histones and bromodomain proteins. The latter are of particular interest as potential therapeutic targets.
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Developments in drug design strategies for bromodomain protein inhibitors to target Plasmo..
Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning..
Displaying the 9 most recent projects by Michael Duffy.
The Role Of Novel And Essential Bromodomain Proteins In Coordinating Malaria Parasite Gene Regulation And Their Potential As Anti-Malarial Targets
Malaria kills over 400,000 people a year and new therapies are needed. Malaria parasites activate groups of genes by novel mechanisms that c..
Internal Research Grant
Displaying the 53 most recent scholarly works by Michael Duffy.
Evolution of antimalarial drug resistance markers in the reservoir of Plasmodium falciparum infections in the Upper East Region of Ghana.
Charles A Narh, Anita Ghansah, Michael F Duffy, Shazia Ruybal-Pesántez, Christiana O Onwona, Abraham R Oduro, Kwadwo A Koram, Karen P Day, Kathryn E Tiedje
Journal article | 2020 | The Journal of Infectious Diseases
BACKGROUND: The majority of Plasmodium falciparum infections, constituting the reservoir in all ages, are asymptomatic in high tra..
Developments in drug design strategies for bromodomain protein inhibitors to target Plasmodium falciparum parasites.
Hanh HT Nguyen, Lee M Yeoh, Scott A Chisholm, Michael F Duffy
Journal article | 2020 | Expert opinion on drug discovery
Introduction: Bromodomains (BRDs) bind to acetylated lysine residues, often on histones. The BRD proteins can contribute to gene r..
Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance
Tuo Yang, Lee M Yeoh, Madel V Tutor, Matthew W Dixon, Paul J McMillan, Stanley C Xie, Jessica L Bridgford, David L Gillett, Michael F Duffy, Stuart A Ralph, Malcolm J McConville, Leann Tilley, Simon A Cobbold
Journal article | 2019 | Cell Reports
Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression
Anna Bachmann, Ellen Bruske, Ralf Krumkamp, Louise Turners, J Stephan Wichers, Michaels Petter, Jana Held, Michael F Duffy, B Kim Lee Sim, Stephen L Hoffman, Peter G Kremsner, Bertrand Lell, Thomas Laystsen, Matthias Frank, Benjamin Mordmueller, Egbert Tannich
Journal article | 2019 | PLOS Pathogens
The pathogenesis of Plasmodium falciparum malaria is linked to the variant surface antigen PfEMP1, which mediates tethering of inf..
Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria.
Aaron Jex, Ivo Mueller, Stefan Kappe, Sebastian Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Lindner, Erika Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha Emery, Sarah Charnaud, Jeffrey Smith, Nicholas Merrienne, Kristian Swearingen, Robert Moritz, Michaela Petter, M Duffy, Veruda Chuenchob
Journal article | 2019 | International Journal for Parasitology
Plasmodium vivax is the key obstacle to malaria elimination in Asia and Latin America, largely attributed to its ability to form r..
GLOBAL STRUCTURE OF THE VAR GENES ENCODING THE MAJOR VARIANT SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM
Gerry Tonkin-Hill, Shazia Ruybal-Pesantez, Kathryn E Tiedje, Virginie Rougeron, Sedigheh Zakeri, Tepanata Pumpaibool, Pingchai Harnyuttanakorn, OraLee H Branch, Lastenia Ruiz-Mesia, Michael F Duffy, Thomas S Rask, Franck Prugnolle, Yao-Ban Yao-Ban Chan, Anthony T Papenfuss, Karen P Day
Conference Proceedings | 2019 | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
A high parasite density environment induces transcriptional changes and cell death in Plasmodium falciparum blood stages
Evelyn S Chou, Sabia Z Abidi, Marian Teye, Aleksandra Leliwa-Sytek, Thomas S Rask, Simon A Cobbold, Gerry Q Tonkin-Hill, Krishanthi S Subramaniam, Anna E Sexton, Darren J Creek, Johanna P Daily, Michael F Duffy, Karen P Day
Journal article | 2018 | The FEBS Journal
The &ITPlasmodium falciparum &ITtranscriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding &ITvar &ITgenes
Gerry Q Tonkin-Hill, Leily Trianty, Rintis Noviyanti, Hanh HT Nguyen, Boni F Sebayang, Daniel A Lampah, Jutta Marfurt, Simon A Cobbold, Janavi S Rambhatla, Malcolm J McConville, Stephen J Rogerson, Graham Brown, Karen P Day, Ric N Price, Nicholas M Anstey, Anthony T Papenfuss, Michael F Duffy
Journal article | 2018 | PLOS Biology
Patterns of protective associations differ for antibodies to &ITP&IT. &ITfalciparum&IT-infected erythrocytes and merozoites in immunity against malaria in children
Jo-Anne Chan, Danielle Stanisic, Michael F Duffy, Leanne J Robinson, Enmoore Lin, James W Kazura, Christopher L King, Peter M Siba, Freya J Fowkes, Ivo Mueller, James G Beeson
Journal article | 2017 | European Journal of Immunology
A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies
Jo-Anne Chan, Katherine B Howell, Christine Langer, Alexander G Maier, Wina Hasang, Stephen J Rogerson, Michaela Petter, Joanne Chesson, Danielle I Stanisic, Michael F Duffy, Brian M Cooke, Peter M Siba, Ivo Mueller, Peter C Bull, Kevin Marsh, Freya JI Fowkes, James G Beeson
Journal article | 2016 | CELLULAR AND MOLECULAR LIFE SCIENCES
Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria
Michael F Duffy, Rintis Noviyanti, Takafumi Tsuboi, Zhi-Ping Feng, Leily Trianty, Boni F Sebayang, Eizo Takashima, Fransisca Sumardy, Daniel A Lampah, Louise Turner, Thomas Lavstsen, Freya JI Fowkes, Peter Siba, Stephen J Rogerson, Thor G Theander, Jutta Marfurt, Ric N Price, Nicholas M Anstey, Graham V Brown, Anthony T Papenfuss
Journal article | 2016 | MALARIA JOURNAL
Mosquito Passage Dramatically Changes var Gene Expression in Controlled Human Plasmodium falciparum Infections
Anna Bachmann, Michaela Petter, Ralf Krumkamp, Meral Esen, Jana Held, Judith AM Scholz, Tao Li, B Kim Lee Sim, Stephen L Hoffman, Peter G Kremsner, Benjamin Mordmueller, Michael F Duffy, Egbert Tannich
Journal article | 2016 | PLOS Pathogens
A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression
Gabrielle A Josling, Michaela Petter, Sophie C Oehring, Archna P Gupta, Olivier Dietz, Danny W Wilson, Thomas Schubert, Gernot Laengst, Paul R Gilson, Brendan S Crabb, Suzette Moes, Paul Jenoe, Shu Wei Lim, Graham V Brown, Zbynek Bozdech, Till S Voss, Michael F Duffy
Journal article | 2015 | Cell Host & Microbe
H2A.Z and H2B.Z double-variant nucleosomes define intergenic regions and dynamically occupy var gene promoters in the malaria parasite Plasmodium falciparum
Michaela Petter, Shamista A Selvarajah, Chin Chin Lee, Wai Hoe Chin, Archna P Gupta, Zbynek Bozdech, Graham V Brown, Michael F Duffy
Journal article | 2013 | Molecular Microbiology
Plasmodium falciparum Malaria Elicits Inflammatory Responses that Dysregulate Placental Amino Acid Transport
Philippe Boeuf, Elizabeth H Aitken, Upeksha Chandrasiri, Caroline Lin Lin Chua, Bernie McInerney, Leon McQuade, Michael Duffy, Malcolm Molyneux, Graham Brown, Jocelyn Glazier, Stephen J Rogerson
Journal article | 2013 | PLOS PATHOGENS
Temporal Expression and Localization Patterns of Variant Surface Antigens in Clinical Plasmodium falciparum Isolates during Erythrocyte Schizogony
Anna Bachmann, Michaela Petter, Ann-Kathrin Tilly, Laura Biller, Karin A Uliczka, Michael F Duffy, Egbert Tannich, Iris Bruchhaus
Journal article | 2012 | PLoS One
Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity
Jo-Anne Chan, Katherine B Howell, Linda Reiling, Ricardo Ataide, Claire L Mackintosh, Freya JI Fowkes, Michaela Petter, Joanne M Chesson, Christine Langer, George M Warimwe, Michael F Duffy, Stephen J Rogerson, Peter C Bull, Alan F Cowman, Kevin Marsh, James G Beeson
Journal article | 2012 | JOURNAL OF CLINICAL INVESTIGATION
PfSET10, a Plasmodium falciparum Methyltransferase, Maintains the Active var Gene in a Poised State during Parasite Division
Jennifer C Volz, Richard Bartfai, Michaela Petter, Christine Langer, Gabrielle A Josling, Takafumi Tsuboi, Frank Schwach, Jake Baum, Julian C Rayner, Henk G Stunnenberg, Michael F Duffy, Alan F Cowman
Journal article | 2012 | Cell Host & Microbe
Evaluation of the Antigenic Diversity of Placenta-Binding Plasmodium falciparum Variants and the Antibody Repertoire among Pregnant Women
Mirja Hommel, Salenna R Elliott, Viju Soma, Greg Kelly, Freya JI Fowkes, Joanne M Chesson, Michael F Duffy, Joseph Bockhorst, Marion Avril, Ivo Mueller, Andrew Raiko, Danielle I Stanisic, Stephen J Rogerson, Joseph D Smith, James G Beeson
Journal article | 2010 | INFECTION AND IMMUNITY
LIMITED GLOBAL DIVERSITY OF ANTIBODY EPITOPES EXPRESSED BY PLACENTAL BINDING PLASMODIUM FALCIPARUM VARIANTS
Mirja Hommel, Salenna R Elliott, Greg Kelly, Freya J Fowkes, Michael F Duffy, Joanne Chesson, Danielle I Stanisic, Ivo Mueller, Marion Avril, Viju Soma, Joseph D Smith, Stephen J Rogerson, James G Beeson
Conference Proceedings | 2009 | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Sir2 Paralogues Cooperate to Regulate Virulence Genes and Antigenic Variation in Plasmodium falciparum
Christopher J Tonkin, Celine K Carret, Manoj T Duraisingh, Till S Voss, Stuart A Ralph, Mirja Hommel, Michael F Duffy, Liliana Mancio da Silva, Artur Scherf, Alasdair Ivens, Terence P Speed, James G Beeson, Alan F Cowman
Journal article | 2009 | PLoS Biology
Study of molecular mechanism of pregnancy-associated malaria in Indonesia: characterization of Plasmodium falciparum var gene of peripheral and placental isolates.
Rintis Noviyanti, Leily Trianty, Jeanne Poespoprodjo, Harsha Dadlani, Nugradzia Nursamsy, Hidayat Trimarsanto, Daniel Lampah, Enny Kenangalem, Emiliana Tjitra, Ric Price, Graham Brown, Michael Duffy, Nicholas Anstey, Stephen Rogerson
Conference Proceedings | 2008 | INTERNATIONAL JOURNAL FOR PARASITOLOGY
Structural basis for binding of Plasmodium falciparum erythrocyte membrane protein 1 to chondroitin sulfate and placental tissue and the influence of protein polymorphisms on binding specificity
James G Beeson, Katherine T Andrews, Michelle Boyle, Michael F Duffy, Ee Ken Choong, Tim J Byrne, Joanne M Chesson, Alexander M Lawson, Wengang Chai
Journal article | 2007 | Journal of Biological Chemistry
Antibody recognition of heterologous variant surface antigens after a single Plasmodium falciparum infection in previously naive adults
Salenna R Elliott, Paul D Payne, Michael F Duffy, Timothy J Byrne, Wai-Hong Tham, Stephen J Rogerson, Graham V Brown, Damon P Eisen
Journal article | 2007 | American Journal of Tropical Medicine and Hygiene
Evidence that Plasmodium falciparum chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing and activation
Allison J Marty, Jennifer K Thompson, Michael F Duffy, Till S Voss, Alan F Cowman, Brendan S Crabb
Journal article | 2006 | MOLECULAR MICROBIOLOGY
Transcribed var genes associated with placental malaria in Malawian women
Michael F Duffy, Aphrodite Caragounis, Rintis Noviyanti, Helen M Kyriacou, Ee Ken Choong, Katja Boysen, Julie Healer, J Alexandra Rowe, Malcolm E Molyneux, Graham V Brown, Stephen J Rogerson
Journal article | 2006 | Infection and Immunity
VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum
Michael F Duffy, Alexander G Maier, Timothy J Byrne, Allison J Marty, Salenna R Elliott, Matthew T O'Neill, Paul D Payne, Stephen J Rogerson, Alan F Cowman, Brendan S Crabb, Graham V Brown
Journal article | 2006 | Molecular and Biochemical Parasitology
Indirect enzyme-linked immunosorbent assay for detection of immunoglobulin g reactive with a recombinant protein expressed from the gene encoding the 116-kilodalton protein of Mycoplasma pneumoniae
MF Duffy, KG Whithear, AH Noormohammadi, PF Markham, M Catton, J Leydon, GF Browning
Journal article | 1999 | Journal of Clinical Microbiology
Displaying the most recent news article by Michael Duffy.
Honours, Awards and Fellowships
travel award $3,500
travel award $7,500
Early Career Researcher Award $33,864
Senior Research Fellow
Microbiology And Immunology
Themis Dept Access
Medicine - Royal Melbourne Hospital
Medicine - Royal Melbourne Hospital
Australian Society for Microbiology
Australian Epigenetics Alliance
Australian Society for Parasitology
Australian Society for Medical Research
Doctor of Philosophy
University of Melbourne
Bachelor of Science
University of Melbourne