Michael Duffy

Characterisation of PfCZIF1 and PfCZIF2 in Plasmodium falciparum asexual stages.

Juan M Balbin, Gary K Heinemann, Lee M Yeoh, Tim-Wolf Gilberger, Mark Armstrong, Michael F Duffy, Paul R Gilson, Danny W Wilson

Journal article  |  2023  |  Int J Parasitol

Plasmodium falciparum exerts strong temporal control of gene expression across its lifecycle. Proteins expressed exclusively durin..

Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass

Michael F Duffy, Gerry Q Tonkin-Hill, Leily Trianty, Rintis Noviyanti, Hanh HT Nguyen, Janavi S Rambhatla, Malcolm J McConville, Stephen J Rogerson, Graham V Brown, Ric N Price, Nicholas M Anstey, Karen P Day, Anthony T Papenfuss

Journal article  |  2022  |  NATURE COMMUNICATIONS

The Putative Bromodomain Protein PfBDP7 of the Human Malaria Parasite Plasmodium Falciparum Cooperates With PfBDP1 in the Silencing of Variant Surface Antigen Expression

Jennifer E Quinn, Myriam D Jeninga, Katharina Limm, Kapil Pareek, Tina Meissgeier, Anna Bachmann, Michael F Duffy, Michaela Petter

Journal article  |  2022  |  FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Epigenetic regulation is a critical mechanism in controlling virulence, differentiation, and survival of the human malaria parasit..

An accurate method for identifying recent recombinants from unaligned sequences

Qian Feng, Kathryn E Tiedje, Shazia Ruybal-Pesantez, Gerry Tonkin-Hill, Michael F Duffy, Karen P Day, Heejung Shim, Yao-Ban Chan

Journal article  |  2022  |  BIOINFORMATICS

MOTIVATION: Recombination is a fundamental process in molecular evolution, and the identification of recombinant sequences is thus..

Identifying Targets of Protective Antibodies against Severe Malaria in Papua, Indonesia, Using Locally Expressed Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1

Janavi S Rambhatla, Gerry Q Tonkin-Hill, Eizo Takashima, Takafumi Tsuboi, Rintis Noviyanti, Leily Trianty, Boni F Sebayang, Daniel A Lampah, Jutta Marfurt, Ric N Price, Nicholas M Anstey, Anthony T Papenfuss, Timon Damelang, Amy W Chung, Michael F Duffy, Stephen J Rogerson

Journal article  |  2022  |  INFECTION AND IMMUNITY

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a diverse family of multidomain proteins expressed on the surface o..

RNAseq of Infected Erythrocyte Surface Antigen-Encoding Genes.

Hanh Hong Thi Nguyen, Suffian Azizan, Lee Ming Yeoh, Jingyi Tang, Michael F Duffy

Journal article  |  2022  |  Methods Mol Biol

Massive parallel sequencing technology has greatly increased the breadth and depth of transcriptomic data that can be captured fro..

Safety, infectivity and immunogenicity of a Chick for genetically attenuated blood-stage malaria updates vaccine

Rebecca Webster, Silvana Sekuloski, Anand Odedra, Stephen Woolley, Helen Jennings, Fiona Amante, Katharine R Trenholme, Julie Healer, Alan F Cowman, Emily M Eriksson, Priyanka Sathe, Jocelyn Penington, Adam J Blanch, Matthew WA Dixon, Leann Tilley, Michael F Duffy, Alister Craig, Janet Storm, Jo-Anne Chan, Krystal Evans, et al.

Journal article  |  2021  |  BMC MEDICINE

BACKGROUND: There is a clear need for novel approaches to malaria vaccine development. We aimed to develop a genetically attenuate..

Common virulence gene expression in adult first-time infected malaria patients and severe cases

J Stephan Wichers, Gerry Tonkin-Hill, Thorsten Thye, Ralf Krumkamp, Benno Kreuels, Jan Strauss, Heidrun von Thien, Judith AM Scholz, Helle Smedegaard Hansson, Rasmus Weisel Jensen, Louise Turner, Freia-Raphaella Lorenz, Anna Schollhorn, Iris Bruchhaus, Egbert Tannich, Rolf Fendel, Thomas D Otto, Thomas Lavstsen, Tim W Gilberger, Michael F Duffy, et al.

Journal article  |  2021  |  ELIFE

Sequestration of Plasmodium falciparum(P. falciparum)-infected erythrocytes to host endothelium through the parasite-derived P. fa..

Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents

Gerry Tonkin-Hill, Shazia Ruybal-Pesantez, Kathryn E Tiedje, Virginie Rougeron, Michael F Duffy, Sedigheh Zakeri, Tepanata Pumpaibool, Pongchai Harnyuttanakorn, OraLee H Branch, Lastenia Ruiz-Mesia, Thomas S Rask, Franck Prugnolle, Anthony T Papenfuss, Yao-ban Chan, Karen P Day

Journal article  |  2021  |  PLOS GENETICS

Malaria remains a major public health problem in many countries. Unlike influenza and HIV, where diversity in immunodominant surfa..

Histone modifications associated with gene expression and genome accessibility are dynamically enriched at Plasmodium falciparum regulatory sequences

Jingyi Tang, Scott A Chisholm, Lee M Yeoh, Paul R Gilson, Anthony T Papenfuss, Karen P Day, Michaela Petter, Michael F Duffy

Journal article  |  2020  |  EPIGENETICS & CHROMATIN

BACKGROUND: The malaria parasite Plasmodium falciparum has an unusually euchromatic genome with poorly conserved positioning of nu..