Michael Duffy

Common virulence gene expression in adult first-time infected malaria patients and severe cases

J Stephan Wichers, Gerry Tonkin-Hill, Thorsten Thye, Ralf Krumkamp, Benno Kreuels, Jan Strauss, Heidrun von Thien, Judith AM Scholz, Helle Smedegaard Hansson, Rasmus Weisel Jensen, Louise Turner, Freia-Raphaella Lorenz, Anna Schollhorn, Iris Bruchhaus, Egbert Tannich, Rolf Fendel, Thomas D Otto, Thomas Lavstsen, Tim W Gilberger, Michael F Duffy, et al.

Journal article  |  2021  |  ELIFE

Sequestration of Plasmodium falciparum(P. falciparum)-infected erythrocytes to host endothelium through the parasite-derived P. fa..

Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents

Gerry Tonkin-Hill, Shazia Ruybal-Pesantez, Kathryn E Tiedje, Virginie Rougeron, Michael F Duffy, Sedigheh Zakeri, Tepanata Pumpaibool, Pongchai Harnyuttanakorn, OraLee H Branch, Lastenia Ruiz-Mesia, Thomas S Rask, Franck Prugnolle, Anthony T Papenfuss, Yao-ban Chan, Karen P Day

Journal article  |  2021  |  PLOS GENETICS

Malaria remains a major public health problem in many countries. Unlike influenza and HIV, where diversity in immunodominant surfa..

Histone modifications associated with gene expression and genome accessibility are dynamically enriched at Plasmodium falciparum regulatory sequences

Jingyi Tang, Scott A Chisholm, Lee M Yeoh, Paul R Gilson, Anthony T Papenfuss, Karen P Day, Michaela Petter, Michael F Duffy

Journal article  |  2020  |  EPIGENETICS & CHROMATIN

BACKGROUND: The malaria parasite Plasmodium falciparum has an unusually euchromatic genome with poorly conserved positioning of nu..

Evolution of Antimalarial Drug Resistance Markers in the Reservoir of Plasmodium falciparum Infections in the Upper East Region of Ghana

Charles A Narh, Anita Ghansah, Michael F Duffy, Shazia Ruybal-Pesantez, Christiana O Onwona, Abraham R Oduro, Kwadwo A Koram, Karen P Day, Kathryn E Tiedje

Journal article  |  2020  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: The majority of Plasmodium falciparum infections, constituting the reservoir in all ages, are asymptomatic in high-tra..

Trends Talk MAM 2020: Growing Strong on the 20th Anniversary

Alexis Kaushansky, Carol Sibley, Geoff McFadden, Susan Charman, Denise Doolan, Michael Good, Erika Flannery, Julie Healer, Michael Duffy, Terrie Taylor, Alister Craig, Leann Tilley, Paul Gilson

Journal article  |  2020  |  TRENDS IN PARASITOLOGY

Developments in drug design strategies for bromodomain protein inhibitors to target Plasmodium falciparum parasites.

Hanh HT Nguyen, Lee M Yeoh, Scott A Chisholm, Michael F Duffy

Journal article  |  2020  |  Expert Opin Drug Discov

Introduction: Bromodomains (BRDs) bind to acetylated lysine residues, often on histones. The BRD proteins can contribute to gene r..

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

Tuo Yang, Lee M Yeoh, Madel V Tutor, Matthew W Dixon, Paul J McMillan, Stanley C Xie, Jessica L Bridgford, David L Gillett, Michael F Duffy, Stuart A Ralph, Malcolm J McConville, Leann Tilley, Simon A Cobbold

Journal article  |  2019  |  CELL REPORTS

Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs) is associated with mutations in Kelch1..

Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression

Anna Bachmann, Ellen Bruske, Ralf Krumkamp, Louise Turners, J Stephan Wichers, Michaels Petter, Jana Held, Michael F Duffy, B Kim Lee Sim, Stephen L Hoffman, Peter G Kremsner, Bertrand Lell, Thomas Laystsen, Matthias Frank, Benjamin Mordmueller, Egbert Tannich

Journal article  |  2019  |  PLOS PATHOGENS

The pathogenesis of Plasmodium falciparum malaria is linked to the variant surface antigen PfEMP1, which mediates tethering of inf..

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria.

Aaron Jex, Ivo Mueller, Stefan Kappe, Sebastian Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Lindner, Erika Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha Emery, Sarah Charnaud, Jeffrey Smith, Nicholas Merrienne, Kristian Swearingen, Robert Moritz, Michaela Petter, M Duffy, Veruda Chuenchob

Journal article  |  2019  |  International Journal for Parasitology

Plasmodium vivax is the key obstacle to malaria elimination in Asia and Latin America, largely attributed to its ability to form r..

GLOBAL STRUCTURE OF THE VAR GENES ENCODING THE MAJOR VARIANT SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM

Gerry Tonkin-Hill, Shazia Ruybal-Pesantez, Kathryn E Tiedje, Virginie Rougeron, Sedigheh Zakeri, Tepanata Pumpaibool, Pingchai Harnyuttanakorn, OraLee H Branch, Lastenia Ruiz-Mesia, Michael F Duffy, Thomas S Rask, Franck Prugnolle, Yao-Ban Yao-Ban Chan, Anthony T Papenfuss, Karen P Day

Conference Proceedings  |  2019  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE