Michael Duffy

Developments in drug design strategies for bromodomain protein inhibitors to target Plasmodium falciparum parasites

Hanh HT Nguyen, Lee M Yeoh, Scott A Chisholm, Michael F Duffy

Journal article  |  2019  |  Expert Opinion on Drug Discovery

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

Tuo Yang, Lee M Yeoh, Madel V Tutor, Matthew W Dixon, Paul J McMillan, Stanley C Xie, Jessica L Bridgford, David L Gillett, Michael F Duffy, Stuart A Ralph, Malcolm J McConville, Leann Tilley, Simon A Cobbold

Journal article  |  2019  |  Cell Reports

Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression

Anna Bachmann, Ellen Bruske, Ralf Krumkamp, Louise Turners, J Stephan Wichers, Michaels Petter, Jana Held, Michael F Duffy, B Kim Lee Sim, Stephen L Hoffman, Peter G Kremsner, Bertrand Lell, Thomas Laystsen, Matthias Frank, Benjamin Mordmueller, Egbert Tannich

Journal article  |  2019  |  PLOS Pathogens

The pathogenesis of Plasmodium falciparum malaria is linked to the variant surface antigen PfEMP1, which mediates tethering of inf..

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria.

Aaron Jex, Ivo Mueller, Stefan Kappe, Sebastian Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Lindner, Erika Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha Emery, Sarah Charnaud, Jeffrey Smith, Nicholas Merrienne, Kristian Swearingen, Robert Moritz, Michaela Petter, M Duffy, Veruda Chuenchob

Journal article  |  2019  |  International Journal for Parasitology

A high parasite density environment induces transcriptional changes and cell death in Plasmodium falciparum blood stages

Evelyn S Chou, Sabia Z Abidi, Marian Teye, Aleksandra Leliwa-Sytek, Thomas S Rask, Simon A Cobbold, Gerry Q Tonkin-Hill, Krishanthi S Subramaniam, Anna E Sexton, Darren J Creek, Johanna P Daily, Michael F Duffy, Karen P Day

Journal article  |  2018  |  The FEBS Journal

The &ITPlasmodium falciparum &ITtranscriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding &ITvar &ITgenes

Gerry Q Tonkin-Hill, Leily Trianty, Rintis Noviyanti, Hanh HT Nguyen, Boni F Sebayang, Daniel A Lampah, Jutta Marfurt, Simon A Cobbold, Janavi S Rambhatla, Malcolm J McConville, Stephen J Rogerson, Graham Brown, Karen P Day, Ric N Price, Nicholas M Anstey, Anthony T Papenfuss, Michael F Duffy

Journal article  |  2018  |  PLOS Biology

Patterns of protective associations differ for antibodies to &ITP&IT. &ITfalciparum&IT-infected erythrocytes and merozoites in immunity against malaria in children

Jo-Anne Chan, Danielle Stanisic, Michael F Duffy, Leanne J Robinson, Enmoore Lin, James W Kazura, Christopher L King, Peter M Siba, Freya J Fowkes, Ivo Mueller, James G Beeson

Journal article  |  2017  |  European Journal of Immunology

Population genomics of virulence genes of Plasmodium falciparum in clinical isolates from Uganda

Shazia Ruybal-Pesantez, Kathryn E Tiedje, Gerry Tonkin-Hill, Thomas S Rask, Moses R Kamya, Bryan Greenhouse, Grant Dorsey, Michael F Duffy, Karen P Day

Journal article  |  2017  |  Scientific Reports

Activation and clustering of a Plasmodium falciparum var gene are affected by subtelomeric sequences

Michael F Duffy, Jingyi Tang, Fransisca Sumardy, Hanh HT Nguyen, Shamista A Selvarajah, Gabrielle A Josling, Karen P Day, Michaela Petter, Graham V Brown

Journal article  |  2017  |  The FEBS Journal

A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies

Jo-Anne Chan, Katherine B Howell, Christine Langer, Alexander G Maier, Wina Hasang, Stephen J Rogerson, Michaela Petter, Joanne Chesson, Danielle I Stanisic, Michael F Duffy, Brian M Cooke, Peter M Siba, Ivo Mueller, Peter C Bull, Kevin Marsh, Freya JI Fowkes, James G Beeson

Journal article  |  2016  |  Cellular and Molecular Life Sciences

Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

Michael F Duffy, Rintis Noviyanti, Takafumi Tsuboi, Zhi-Ping Feng, Leily Trianty, Boni F Sebayang, Eizo Takashima, Fransisca Sumardy, Daniel A Lampah, Louise Turner, Thomas Lavstsen, Freya JI Fowkes, Peter Siba, Stephen J Rogerson, Thor G Theander, Jutta Marfurt, Ric N Price, Nicholas M Anstey, Graham V Brown, Anthony T Papenfuss

Journal article  |  2016  |  Malaria Journal

Mosquito Passage Dramatically Changes var Gene Expression in Controlled Human Plasmodium falciparum Infections

Anna Bachmann, Michaela Petter, Ralf Krumkamp, Meral Esen, Jana Held, Judith AM Scholz, Tao Li, B Kim Lee Sim, Stephen L Hoffman, Peter G Kremsner, Benjamin Mordmueller, Michael F Duffy, Egbert Tannich

Journal article  |  2016  |  PLOS Pathogens

A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression

Gabrielle A Josling, Michaela Petter, Sophie C Oehring, Archna P Gupta, Olivier Dietz, Danny W Wilson, Thomas Schubert, Gernot Laengst, Paul R Gilson, Brendan S Crabb, Suzette Moes, Paul Jenoe, Shu Wei Lim, Graham V Brown, Zbynek Bozdech, Till S Voss, Michael F Duffy

Journal article  |  2015  |  Cell Host & Microbe

Antigenic Variation in Plasmodium falciparum

Michaela Petter, Michael F Duffy

Book Chapter  |  2015  |  Results and Problems in Cell Differentiation

Epigenetic regulation of the Plasmodium falciparum genome

Michael F Duffy, Shamista A Selvarajah, Gabrielle A Josling, Michaela Petter

Journal article  |  2014  |  Briefings in Functional Genomics

H2A.Z and H2B.Z double-variant nucleosomes define intergenic regions and dynamically occupy var gene promoters in the malaria parasite Plasmodium falciparum

Michaela Petter, Shamista A Selvarajah, Chin Chin Lee, Wai Hoe Chin, Archna P Gupta, Zbynek Bozdech, Graham V Brown, Michael F Duffy

Journal article  |  2013  |  Molecular Microbiology

Plasmodium falciparum Malaria Elicits Inflammatory Responses that Dysregulate Placental Amino Acid Transport

Philippe Boeuf, Elizabeth H Aitken, Upeksha Chandrasiri, Caroline Lin Lin Chua, Bernie McInerney, Leon McQuade, Michael Duffy, Malcolm Molyneux, Graham Brown, Jocelyn Glazier, Stephen J Rogerson

Journal article  |  2013  |  PLoS Pathogens

Temporal Expression and Localization Patterns of Variant Surface Antigens in Clinical Plasmodium falciparum Isolates during Erythrocyte Schizogony

Anna Bachmann, Michaela Petter, Ann-Kathrin Tilly, Laura Biller, Karin A Uliczka, Michael F Duffy, Egbert Tannich, Iris Bruchhaus

Journal article  |  2012  |  PLoS One

Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity

Jo-Anne Chan, Katherine B Howell, Linda Reiling, Ricardo Ataide, Claire L Mackintosh, Freya JI Fowkes, Michaela Petter, Joanne M Chesson, Christine Langer, George M Warimwe, Michael F Duffy, Stephen J Rogerson, Peter C Bull, Alan F Cowman, Kevin Marsh, James G Beeson

Journal article  |  2012  |  Journal of Clinical Investigation

The role of chromatin in Plasmodium gene expression

Michael F Duffy, Shamista A Selvarajah, Gabrielle A Josling, Michaela Petter

Journal article  |  2012  |  Cellular Microbiology

The Role of Bromodomain Proteins in Regulating Gene Expression

Gabrielle A Josling, Shamista A Selvarajah, Michaela Petter, Michael F Duffy

Journal article  |  2012  |  Genes

PfSET10, a Plasmodium falciparum Methyltransferase, Maintains the Active var Gene in a Poised State during Parasite Division

Jennifer C Volz, Richard Bartfai, Michaela Petter, Christine Langer, Gabrielle A Josling, Takafumi Tsuboi, Frank Schwach, Jake Baum, Julian C Rayner, Henk G Stunnenberg, Michael F Duffy, Alan F Cowman

Journal article  |  2012  |  Cell Host & Microbe

Expression of P. falciparum var Genes Involves Exchange of the Histone Variant H2A.Z at the Promoter

Michaela Petter, Chin Chin Lee, Timothy J Byrne, Katja E Boysen, Jennifer Volz, Stuart A Ralph, Alan F Cowman, Graham V Brown, Michael F Duffy

Journal article  |  2011  |  PLoS Pathogens

Expression of P.falciparum var Genes Involves Exchange of the Histone Variant H2A.Z at the Promoter

M Petter, C Lee, TJ Byrne, KE Boysen, JC Volz, SAR Ralph, AF Cowman, GV Brown, M Duffy

Journal article  |  2011  |  PLoS Pathogens

Evaluation of the Antigenic Diversity of Placenta-Binding Plasmodium falciparum Variants and the Antibody Repertoire among Pregnant Women

Mirja Hommel, Salenna R Elliott, Viju Soma, Greg Kelly, Freya JI Fowkes, Joanne M Chesson, Michael F Duffy, Joseph Bockhorst, Marion Avril, Ivo Mueller, Andrew Raiko, Danielle I Stanisic, Stephen J Rogerson, Joseph D Smith, James G Beeson

Journal article  |  2010  |  Infection and Immunity

LIMITED GLOBAL DIVERSITY OF ANTIBODY EPITOPES EXPRESSED BY PLACENTAL BINDING PLASMODIUM FALCIPARUM VARIANTS

Mirja Hommel, Salenna R Elliott, Greg Kelly, Freya J Fowkes, Michael F Duffy, Joanne Chesson, Danielle I Stanisic, Ivo Mueller, Marion Avril, Viju Soma, Joseph D Smith, Stephen J Rogerson, James G Beeson

Conference Proceedings  |  2009  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Ectopic Recombination of a Malaria var Gene during Mitosis Associated with an Altered var Switch Rate

Michael F Duffy, Timothy J Byrne, Celine Carret, Alasdair Ivens, Graham V Brown

Journal article  |  2009  |  Journal of Molecular Biology

Sir2 Paralogues Cooperate to Regulate Virulence Genes and Antigenic Variation in Plasmodium falciparum

Christopher J Tonkin, Celine K Carret, Manoj T Duraisingh, Till S Voss, Stuart A Ralph, Mirja Hommel, Michael F Duffy, Liliana Mancio da Silva, Artur Scherf, Alasdair Ivens, Terence P Speed, James G Beeson, Alan F Cowman

Journal article  |  2009  |  PLoS Biology

Mycoplasma recombinant polypeptide and vaccines

GF BROWNING, KG WHITHEAR, MF DUFFY

Patent  |  2009

Characterization of VAR2CSA-deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line

Francisca Yosaatmadja, Katherine T Andrews, Michael F Duffy, Graham V Brown, James G Beeson, Stephen J Rogerson

Journal article  |  2008  |  Malaria Journal

Study of molecular mechanism of pregnancy-associated malaria in Indonesia: characterization of Plasmodium falciparum var gene of peripheral and placental isolates.

Rintis Noviyanti, Leily Trianty, Jeanne Poespoprodjo, Harsha Dadlani, Nugradzia Nursamsy, Hidayat Trimarsanto, Daniel Lampah, Enny Kenangalem, Emiliana Tjitra, Ric Price, Graham Brown, Michael Duffy, Nicholas Anstey, Stephen Rogerson

Conference Proceedings  |  2008  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Structural basis for binding of Plasmodium falciparum erythrocyte membrane protein 1 to chondroitin sulfate and placental tissue and the influence of protein polymorphisms on binding specificity

James G Beeson, Katherine T Andrews, Michelle Boyle, Michael F Duffy, Ee Ken Choong, Tim J Byrne, Joanne M Chesson, Alexander M Lawson, Wengang Chai

Journal article  |  2007  |  Journal of Biological Chemistry

Antibody recognition of heterologous variant surface antigens after a single Plasmodium falciparum infection in previously naive adults

Salenna R Elliott, Paul D Payne, Michael F Duffy, Timothy J Byrne, Wai-Hong Tham, Stephen J Rogerson, Graham V Brown, Damon P Eisen

Journal article  |  2007  |  American Journal of Tropical Medicine and Hygiene

Transcription and coregulation of multigene families in Plasmodium falciparum

Michael F Duffy, Wai-Hong Tham

Journal article  |  2007  |  Trends in Parasitology

Evidence that Plasmodium falciparum chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing and activation

Allison J Marty, Jennifer K Thompson, Michael F Duffy, Till S Voss, Alan F Cowman, Brendan S Crabb

Journal article  |  2006  |  Molecular Microbiology

Transcribed var genes associated with placental malaria in Malawian women

Michael F Duffy, Aphrodite Caragounis, Rintis Noviyanti, Helen M Kyriacou, Ee Ken Choong, Katja Boysen, Julie Healer, J Alexandra Rowe, Malcolm E Molyneux, Graham V Brown, Stephen J Rogerson

Journal article  |  2006  |  Infection and Immunity

VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum

Michael F Duffy, Alexander G Maier, Timothy J Byrne, Allison J Marty, Salenna R Elliott, Matthew T O'Neill, Paul D Payne, Stephen J Rogerson, Alan F Cowman, Brendan S Crabb, Graham V Brown

Journal article  |  2006  |  Molecular and Biochemical Parasitology

A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria

TS Voss, J Healer, AJ Marty, MF Duffy, JK Thompson, JG Beeson, JC Reeder, BS Crabb, AF Cowman

Journal article  |  2006  |  Nature

Targets of protective antibodies to malaria during pregnancy

JG Beeson, SJ Rogerson, SR Elliott, MF Duffy

Journal article  |  2005  |  Journal of Infectious Diseases

Broad analysis reveals a consistent pattern of var gene transcription in Plasmodium falciparum repeatedly selected for a defined adhesion phenotype

MF Duffy, TJ Byrne, SR Elliott, DW Wilson, SJ Rogerson, JG Beeson, R Noviyanti, GV Brown

Journal article  |  2005  |  Molecular Microbiology

Cross-reactive surface epitopes on chondroitin sulfate A-adherent Plasmodium falciparum-infected erythrocytes are associated with transcription of var2csa

SR Elliott, MF Duffy, TJ Byrne, JG Beeson, EJ Mann, DW Wilson, SJ Rogerson, GV Brown

Journal article  |  2005  |  Infection and Immunity

Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium faiciparum

MT Duraisingh, TS Voss, AJ Marty, MF Duffy, RT Good, JK Thompson, LH Freitas-Junior, A Scherf, BS Crabb, AF Cowman

Journal article  |  2005  |  Cell

Regulation of antigenic variation in Plasmodium falciparum: censoring freedom of expression?

MF Duffy, JC Reeder, GV Brown

Journal article  |  2003  |  Trends in Parasitology

Transcription of multiple var genes by individual, trophozoite-stage Plasmodium falciparum cells expressing a chondroitin sulphate A binding phenotype

MF Duffy, GV Brown, W Basuki, EO Krejany, R Noviyanti, AF Cowman, JC Reeder

Journal article  |  2002  |  Molecular Microbiology

Multiple var gene transcripts are expressed in Plasmodium falciparum infected erythrocytes selected for adhesion

R Noviyanti, GV Brown, ME Wickham, MF Duffy, AF Cowman, JC Reeder

Journal article  |  2001  |  Molecular and Biochemical Parasitology

A gene family in Mycoplasma imitans closely related to the pMGA family of Mycoplasma gallisepticum

PF Markham, MF Duffy, MD Glew, GF Browning

Journal article  |  1999  |  Microbiology

Indirect enzyme-linked immunosorbent assay for detection of immunoglobulin g reactive with a recombinant protein expressed from the gene encoding the 116-kilodalton protein of Mycoplasma pneumoniae

MF Duffy, KG Whithear, AH Noormohammadi, PF Markham, M Catton, J Leydon, GF Browning

Journal article  |  1999  |  Journal of Clinical Microbiology

Multigene families encoding the major hemagglutinins in phylogenetically distinct mycoplasmas

AH Noormohammadi, PF Markham, MF Duffy, KG Whithear, GF Browning

Journal article  |  1998  |  Infection and Immunity

Polyacrylamide gel-electrophoresis separation of whole-cell proteins.

MF Duffy, AH Noormohammadi, N Baseggio, GF Browning, PF Markham

Book Chapter  |  1998  |  Methods in Molecular Biology

Immunological and biochemical characterization of membrane proteins.

MF Duffy, AH Noormohammadi, N Baseggio, GF Browning, PF Markham

Book Chapter  |  1998  |  Methods in Molecular Biology

The immunoreactive 116 kDa surface protein of Mycoplasma pneumoniae is encoded in an operon

MF Duffy, ID Walker, GF Browning

Journal article  |  1997  |  Microbiology