Donald Newgreen

RET overactivation leads to concurrent Hirschsprung disease and intestinal ganglioneuromas

Nandor Nagy, Richard A Guyer, Ryo Hotta, Dongcheng Zhang, Donald F Newgreen, Viktoria Halasy, Tamas Kovacs, Allan M Goldstein

Journal article  |  2020  |  DEVELOPMENT

Appropriately balanced RET signaling is of crucial importance during embryonic neural crest cell migration, proliferation and diff..

Guidelines and definitions for research on epithelial-mesenchymal transition

Jing Yang, Parker Antin, Geert Berx, Cedric Blanpain, Thomas Brabletz, Marianne Bronner, Kyra Campbell, Amparo Cano, Jordi Casanova, Gerhard Christofori, Shoukat Dedhar, Rik Derynck, Heide L Ford, Jonas Fuxe, Antonio Garcia de Herreros, Gregory J Goodall, Anna-Katerina Hadjantonakis, Ruby JY Huang, Chaya Kalcheim, Raghu Kalluri, et al.

Journal article  |  2020  |  NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenot..

The enteric neural crest progressively loses capacity to form enteric nervous system

Dongcheng Zhang, Benjamin N Rollo, Nandor Nagy, Lincon Stamp, Donald F Newgreen

Journal article  |  2019  |  DEVELOPMENTAL BIOLOGY

Cells of the vagal neural crest (NC) form most of the enteric nervous system (ENS) by a colonising wave in the embryonic gut, with..

Fine scale differences within the vagal neural crest for enteric nervous system formation

Johanna E Simkin, Dongcheng Zhang, Lincon A Stamp, Donald F Newgreen

Journal article  |  2019  |  DEVELOPMENTAL BIOLOGY

The enteric nervous system is mostly derived from vagal neural crest (NC) cells adjacent to somites (s)1-7. We used in ovo focal f..

Addressing Interdisciplinary Difficulties in Developmental Biology/Mathematical Collaborations: A Neural Crest Example

Donald F Newgreen, Kerry A Landman, James M Osborne

Journal article  |  2019  |  NEURAL CREST CELLS

Mathematical modeling can allow insight into the biological processes that can be difficult to access by conventional biological m..

Generation of Neural Crest Progenitors from Human Pluripotent Stem Cells

Kwaku Dad Abu-Bonsrah, Serena Viventi, Donald F Newgreen, Mirella Dottori

Journal article  |  2019  |  NEURAL CREST CELLS

There are a vast range of diseases and disorders that are neurocristopathic in origin, including Hirschsprung's disease, pheochrom..

Technologies for Live Imaging of Enteric Neural Crest-Derived Cells

Marlene M Hao, Annette J Bergner, Donald F Newgreen, Hideki Enomoto, Heather M Young

Journal article  |  2019  |  NEURAL CREST CELLS

Time-lapse imaging of gut explants from embryonic mice in which neural crest-derived cells express fluorescent proteins allows the..

Transserosal migration of enteric neural stem cells: Developing an avian colon model

Boaz Jurkowicz, Dad Abu-Bonsrah, Dongcheng Zhang, John Hutson, Sebastian King, Don Newgreen

Journal article  |  2018  |  JOURNAL OF PEDIATRIC SURGERY

BACKGROUND: Stem cell transplantation is a potential therapy for enteric neuropathies, including Hirschsprung disease. Proof-of-pr..

Stochastic clonal expansion of "superstars" enhances the reserve capacity of enteric nervous system precursor cells

Dongcheng Zhang, James M Osborne, Kwaku Dad Abu-Bonsrah, Bevan L Cheeseman, Kerry A Landman, Boaz Jurkowicz, Donald F Newgreen

Journal article  |  2018  |  Developmental Biology

We quantified cell population increase in the quail embryo enteric nervous system (ENS) from E2.5 (about 1500 cells) to E12 (about..

Development of the Enteric Nervous System

HM Young, LA Stamp, T Uesaka, MM Hao, DF Newgreen, H Enomoto

Book Chapter  |  2018

Enteric neurons and glial cells arise from neural crest cells, most of which emigrate from the caudal hindbrain ("vagal" level) an..