Jonathan Crowston

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

James R Tribble, Amin Otmani, Shanshan Sun, Sevannah A Ellis, Gloria Cimaglia, Rupali Vohra, Melissa Joe, Emma Lardner, Abinaya P Venkataraman, Alberto Dominguez-Vicent, Eirini Kokkali, Seungsoo Rho, Gauti Johnnesson, Robert W Burgess, Peter G Fuerst, Rune Brautaset, Miriam Kolko, James E Morgan, Jonathan G Crowston, Marcela Votruba, et al.

Journal article  |  2021  |  REDOX BIOLOGY

Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for neuronal survival. Glaucoma is a common n..

Retinal energy metabolism in health and glaucoma.

Robert J Casson, Glyn Chidlow, Jonathan G Crowston, Pete A Williams, John PM Wood

Journal article  |  2021  |  Prog Retin Eye Res

Energy metabolism refers to the processes by which life transfers energy to do cellular work. The retina's relatively large energy..

Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma

James R Tribble, Flora Hui, Melissa Joe, Katharina Bell, Vicki Chrysostomou, Jonathan G Crowston, Pete A Williams

Journal article  |  2021  |  CELLS

Glaucoma is a leading cause of blindness worldwide. In glaucoma, a progressive dysfunction and death of retinal ganglion cells occ..

Experimental models of glaucoma filtration surgery.

Rachel S Chong, Jonathan G Crowston, Tina T Wong

Journal article  |  2021  |  Acta Ophthalmol

Glaucoma filtration surgery plays an important role in achieving intraocular pressure (IOP) reduction in patients who have high IO..

A retinal hyperspectral imaging biomarker for Alzheimer’s disease: Preliminary study of the influence of eye diseases on imaging scores

Peter van Wijngaarden, Flora Hui, Darvy Dang, Jason Ha, Christopher J Fowler, Victor LL Villemagne, Christopher C Rowe, Colin L Masters, Robert Williamson, Jonathan G Crowston, Xavier Hadoux

Conference Proceedings  |  2020  |  Alzheimer's & Dementia

Nox4 Facilitates TGF beta 1-Induced Fibrotic Response in Human Tenon's Fibroblasts and Promotes Wound Collagen Accumulation in Murine Model of Glaucoma Filtration Surgery

Manisha H Shah, Elsa C Chan, Nicole J Van Bergen, Surinder S Pandav, Sze Ng, Jonathan G Crowston, Hitesh M Peshavariya

Journal article  |  2020  |  ANTIOXIDANTS

Collagen accumulation in sub-conjunctival tissue at the surgical wound is one of the major complications associated with glaucoma ..

Prevalence and associations of non-retinopathy ocular conditions among older Australians with self-reported diabetes: The National Eye Health Survey

Joshua Foreman, Stuart Keel, Myra B McGuinness, Jonathan G Crowston, Hugh R Taylor, Mohamed Dirani

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF OPHTHALMOLOGY

AIM: To determine the prevalence and associations of non-retinopathy ocular conditions among older Australian adults with diabetes..

Nuclear response to divergent mitochondrial DNA genotypes modulates the interferon immune response

M Isabel G Lopez Sanchez, Mark Ziemann, Annabell Bachem, Rahul Makam, Jonathan G Crowston, Carl A Pinkert, Matthew McKenzie, Sammy Bedoui, Ian A Trounce

Journal article  |  2020  |  PLOS ONE

Mitochondrial OXPHOS generates most of the energy required for cellular function. OXPHOS biogenesis requires the coordinated expre..

Is physical activity protective against myopia?

Joshua Foreman, Jonathan G Crowston, Mohamed Dirani

Journal article  |  2020  |  BRITISH JOURNAL OF OPHTHALMOLOGY

Artificial Intelligence Algorithms to Diagnose Glaucoma and Detect Glaucoma Progression: Translation to Clinical Practice.

Anna S Mursch-Edlmayr, Wai Siene Ng, Alberto Diniz-Filho, David C Sousa, Louis Arnold, Matthew B Schlenker, Karla Duenas-Angeles, Pearse A Keane, Jonathan G Crowston, Hari Jayaram

Journal article  |  2020  |  Transl Vis Sci Technol

Purpose: This concise review aims to explore the potential for the clinical implementation of artificial intelligence (AI) strateg..