Dr Howitt is a neurobiologist studying biochemical pathways in brain development and disease. His research has identified important pathways for the trafficking of metals in the brain and how failure of these systems can contribute to Parkinson’s disease.
More recently he has identified an important role for the tumour suppressor protein PTEN in the regulation of brain size during development. This research has important implications for understanding autism. Dr Howitt’s career includes positions at Brookhaven National Laboratory, New York and Imperial College London. He currently heads the Protein Trafficking and Signalling laboratory at the Florey Institute of Neuroscience and Mental Health at the University of Melbourne.
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Displaying the 5 most recent projects by Jason Howitt.
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Displaying the 30 most recent scholarly works by Jason Howitt.
P53: A Guardian of Immunity Becomes Its Saboteur through Mutation
Arjelle Decasa Agupitan, Paul Neeson, Scott Williams, Jason Howitt, Sue Haupt, Ygal Haupt
Journal article | 2020 | International Journal of Molecular Sciences
Awareness of the importance of immunity in controlling cancer development triggered research into the impact of its key oncogenic ..
Nedd4 Family Interacting Protein 1 (Ndfip1) Is Required for Ubiquitination and Nuclear Trafficking of BRCA1-associated ATM Activator 1 (BRAT1) during the DNA Damage Response
Ley-Hian Low, Yuh-Lit Chow, Yijia Li, Choo-Peng Goh, Ulrich Putz, John Silke, Toru Ouchi, Jason Howitt, Seong-Seng Tan
Journal article | 2015 | Journal of Biological Chemistry
Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4( ) T cells
John A Altin, Stephen R Daley, Jason Howitt, Helen J Rickards, Alison K Batkin, Keisuke Horikawa, Simon J Prasad, Keats A Nelms, Sharad Kumar, Lawren C Wu, Seong-Seng Tan, Matthew C Cook, Christopher C Goodnow
Journal article | 2014 | Proceedings of the National Academy of Sciences of the United States of America
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia
Jason Howitt, Jenny Lackovic, Ley-Hian Low, Adam Naguib, Alison Macintyre, Choo-Peng Goh, Jennifer K Callaway, Vicki Hammond, Tim Thomas, Matthew Dixon, Ulrich Putz, John Silke, Perry Bartlett, Baoli Yang, Sharad Kumar, Lloyd C Trotman, Seong-Seng Tan
Journal article | 2012 | Journal of Cell Biology
Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons
Jason Howitt, Ulrich Putz, Jenny Lackovic, Anh Doan, Loretta Dorstyn, Hong Cheng, Baoli Yang, Chan-Ling Tailoi, John Silke, Sharad Kumar, Seong-Seng Tan
Journal article | 2009 | Proceedings of the National Academy of Sciences of the United States of America
BDNF Exerts Contrasting Effects on Peripheral Myelination of NGF-Dependent and BDNF-Dependent DRG Neurons
Junhua Xiao, Agnes W Wong, Melanie M Willingham, Selma K Kaasinen, Ian A Hendry, Jason Howitt, Ulrich Putz, Graham L Barrett, Trevor J Kilpatrick, Simon S Murray
Journal article | 2009 | Journal of Neuroscience
A molecular mechanism for the heparan sulfate dependence of Slit-Robo signaling
Sadaf-Ahmahni Hussain, Michael Piper, Noemi Fukuhara, Laure Strochlic, Gian Cho, Jason A Howitt, Yassir Ahmed, Andrew K Powell, Jeremy E Turnbull, Christine E Holt, Erhard Hohenester
Journal article | 2006 | Journal of Biological Chemistry
Honours, Awards and Fellowships
NHMRC Howard Florey Centenary Fellow
Florey Department Of Neuroscience And Mental Health
Swinburne University of Technology
Swinburne University of Technology