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Dr

Jason Howitt

Honorary
Florey Department of Neuroscience and Mental Health
Brain development
Parkinson's disease
science & technology
life sciences & biomedicine
animals
humans
membrane proteins
carrier proteins
mice
Jason Howitt's Profile Picture
Dr

Jason Howitt

 
Division
Medicine, Dentistry and Health Sciences
 
Primary Interest
Neurodegenerative disorders
Jason Howitt's Profile Picture
Dr

Jason Howitt

 
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Jason's  Short Profile
 

Projects

Displaying the 5 most recent projects by Jason Howitt.

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Targeting autism with macrocephaly using mechanism-based therapeutics.

2016 - 2016
Completed
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THE REGULATION OF IRON TRANSPORT IN PARKINSON'S DISEASE

Currently there is no cure for Parkinson's disease, and although we have a number of treatments to manage the disease there is an urgent nee..

2014 - 2016
Completed
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THE ROLE OF PTEN TRAFFICKING IN NORMAL AND ABNORMAL CORTICAL DEVELOPMENT

Autism is a complex neurodevelopmental disorder that is estimated to affect 1 in every 100 children. Currently we have no medical treatments..

2014 - 2016
Completed
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The role of Ubiquitin ligase adaptor protein NDFIP1 in neuronal development

Many brain diseases are characterized by faulty connections between nerve cells (neurons), in some cases caused by the inability to remove u..

2011 - 2013
Completed
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The functional role of Slit-Robo signaling in interneuron migration

In the developing brain of vertebrates interneurons undergo directed migration to form complex networks that result in the regulation of neu..

5

Projects

Project Types

4

Research Grant

1

Internal Research Grant

Scholarly Works

Displaying the 10 most recent scholarly works by Jason Howitt.

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P53: A Guardian of Immunity Becomes Its Saboteur through Mutation

Arjelle Decasa Agupitan, Paul Neeson, Scott Williams, Jason Howitt, Sue Haupt, Ygal Haupt

Journal article  |  2020  |  International Journal of Molecular Sciences

Awareness of the importance of immunity in controlling cancer development triggered research into the impact of its key oncogenic ..

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Initiation and Transmission of α-Synuclein Pathology in Parkinson's Disease.

Alex Mazurskyy, Jason Howitt

Journal article  |  2019  |  Neurochemical Research

The pathogenesis of Parkinson's disease (PD) involves the accumulation of aggregated forms of α-synuclein in the body. The locatio..

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Ubiquitin Regulation of Trk Receptor Trafficking and Degradation

SS Murray, AW Wong, J Yang, Y Li, U Putz, S-S Tan, J Howitt

Journal article  |  2019  |  Molecular Neurobiology

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The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8( ) T Cell Tolerance Checkpoint to High-Dose Antigen

Mayura Wagle, Julia M Marchingo, Jason Howitt, Seong-Seng Tan, Christopher C Goodnow, Ian A Parish

Journal article  |  2018  |  Cell Reports

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Engineered Exosomes as Vehicles for Biologically Active Proteins

Ulrich Sterzenbach, Ulrich Putz, Ley-Hian Low, John Silke, Seong-Seng Tan, Jason Howitt

Journal article  |  2017  |  Molecular Therapy

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Exosomes in the Pathology of Neurodegenerative Diseases

Jason Howitt, Andrew F Hill

Journal article  |  2016  |  Journal of Biological Chemistry

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PTEN secretion in exosomes

Ulrich Putz, Sophia Mah, Choo-Peng Goh, Ley-Hian Low, Jason Howitt, Seong-Seng Tan

Journal article  |  2015  |  Methods

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Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity

Jason Howitt, Ley-Hian Low, Ulrich Putz, Anh Doan, Jenny Lackovic, Choo-Peng Goh, Jenny Gunnersen, John Silke, Seong-Seng Tan

Journal article  |  2015  |  Journal of Molecular Cell Biology

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Nedd4 Family Interacting Protein 1 (Ndfip1) Is Required for Ubiquitination and Nuclear Trafficking of BRCA1-associated ATM Activator 1 (BRAT1) during the DNA Damage Response

Ley-Hian Low, Yuh-Lit Chow, Yijia Li, Choo-Peng Goh, Ulrich Putz, John Silke, Toru Ouchi, Jason Howitt, Seong-Seng Tan

Journal article  |  2015  |  Journal of Biological Chemistry

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Ndfip1 Is Required for the Development of Pyramidal Neuron Dendrites and Spines in the Neocortex

Vicki E Hammond, Jenny M Gunnersen, Choo-Peng Goh, Ley-Hian Low, Tomoko Hyakumura, Michelle M Tang, Joanne M Britto, Ulrich Putz, Jason A Howitt, Seong-Seng Tan

Journal article  |  2014  |  Cerebral Cortex

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Scholarly Works

Keyword Analysis

Neurosciences
Biochemistry and Cell Biology
Clinical Health (organs, Diseases and Abnormal Conditions)
Expanding Knowledge
Medical Biochemistry and Metabolomics
Inorganic Chemistry
Public Health
Immunology
Clinical (organs, Diseases and Abnormal Conditions)
Oncology and Carcinogenesis

Honours, Awards and Fellowships

2006

NHMRC Howard Florey Centenary Fellow

1

Award

Credentials

Positions

Honorary

Florey Department of Neuroscience and Mental Health

Education

Biochemistry

Swinburne University of Technology

Biochemistry

Swinburne University of Technology

Links