Jason Howitt

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation

Arjelle Decasa Agupitan, Paul Neeson, Scott Williams, Jason Howitt, Sue Haupt, Ygal Haupt

Journal article  |  2020  |  International Journal of Molecular Sciences

Awareness of the importance of immunity in controlling cancer development triggered research into the impact of its key oncogenic ..

Initiation and Transmission of α-Synuclein Pathology in Parkinson's Disease.

Alex Mazurskyy, Jason Howitt

Journal article  |  2019  |  Neurochemical Research

The pathogenesis of Parkinson's disease (PD) involves the accumulation of aggregated forms of α-synuclein in the body. The locatio..

Ubiquitin Regulation of Trk Receptor Trafficking and Degradation

SS Murray, AW Wong, J Yang, Y Li, U Putz, S-S Tan, J Howitt

Journal article  |  2019  |  Molecular Neurobiology

The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8( ) T Cell Tolerance Checkpoint to High-Dose Antigen

Mayura Wagle, Julia M Marchingo, Jason Howitt, Seong-Seng Tan, Christopher C Goodnow, Ian A Parish

Journal article  |  2018  |  Cell Reports

Engineered Exosomes as Vehicles for Biologically Active Proteins

Ulrich Sterzenbach, Ulrich Putz, Ley-Hian Low, John Silke, Seong-Seng Tan, Jason Howitt

Journal article  |  2017  |  Molecular Therapy

Exosomes in the Pathology of Neurodegenerative Diseases

Jason Howitt, Andrew F Hill

Journal article  |  2016  |  Journal of Biological Chemistry

PTEN secretion in exosomes

Ulrich Putz, Sophia Mah, Choo-Peng Goh, Ley-Hian Low, Jason Howitt, Seong-Seng Tan

Journal article  |  2015  |  Methods

Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity

Jason Howitt, Ley-Hian Low, Ulrich Putz, Anh Doan, Jenny Lackovic, Choo-Peng Goh, Jenny Gunnersen, John Silke, Seong-Seng Tan

Journal article  |  2015  |  Journal of Molecular Cell Biology

Nedd4 Family Interacting Protein 1 (Ndfip1) Is Required for Ubiquitination and Nuclear Trafficking of BRCA1-associated ATM Activator 1 (BRAT1) during the DNA Damage Response

Ley-Hian Low, Yuh-Lit Chow, Yijia Li, Choo-Peng Goh, Ulrich Putz, John Silke, Toru Ouchi, Jason Howitt, Seong-Seng Tan

Journal article  |  2015  |  Journal of Biological Chemistry

Ndfip1 Is Required for the Development of Pyramidal Neuron Dendrites and Spines in the Neocortex

Vicki E Hammond, Jenny M Gunnersen, Choo-Peng Goh, Ley-Hian Low, Tomoko Hyakumura, Michelle M Tang, Joanne M Britto, Ulrich Putz, Jason A Howitt, Seong-Seng Tan

Journal article  |  2014  |  Cerebral Cortex

Rab5 and Ndfip1 Are Involved in Pten Ubiquitination and Nuclear Trafficking

Yijia Li, Ley-Hian Low, Ulrich Putz, Choo-Peng Goh, Seong-Seng Tan, Jason Howitt

Journal article  |  2014  |  Traffic

Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4( ) T cells

John A Altin, Stephen R Daley, Jason Howitt, Helen J Rickards, Alison K Batkin, Keisuke Horikawa, Simon J Prasad, Keats A Nelms, Sharad Kumar, Lawren C Wu, Seong-Seng Tan, Matthew C Cook, Christopher C Goodnow

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

Nuclear trafficking of Pten after brain injury leads to neuron survival not death

Choo-Peng Goh, Ulrich Putz, Jason Howitt, Ley-Hian Low, Jenny Gunnersen, Nicole Bye, Cristina Morganti-Kossmann, Seong-Seng Tan

Journal article  |  2014  |  Experimental Neurology

Increased Ndfip1 in the Substantia Nigra of Parkinsonian Brains Is Associated with Elevated Iron Levels

Jason Howitt, Amanda M Gysbers, Scott Ayton, Francine Carew-Jones, Ulrich Putz, David I Finkelstein, Glenda M Halliday, Seong-Seng Tan

Journal article  |  2014  |  PLoS One

Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development

Choo-Peng Goh, Ley-Hian Low, Ulrich Putz, Jenny Gunnersen, Vicki Hammond, Jason Howitt, Seong-Seng Tan

Journal article  |  2013  |  NEUROSCIENCE LETTERS

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

Ulrich Putz, Jason Howitt, Anh Doan, Choo-Peng Goh, Ley-Hian Low, John Silke, Seong-Seng Tan

Journal article  |  2012  |  Science Signaling

Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke

Jenny Lackovic, Jason Howitt, Jennifer K Callaway, John Silke, Perry Bartlett, Seong-Seng Tan

Journal article  |  2012  |  Experimental Neurology

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia

Jason Howitt, Jenny Lackovic, Ley-Hian Low, Adam Naguib, Alison Macintyre, Choo-Peng Goh, Jennifer K Callaway, Vicki Hammond, Tim Thomas, Matthew Dixon, Ulrich Putz, John Silke, Perry Bartlett, Baoli Yang, Sharad Kumar, Lloyd C Trotman, Seong-Seng Tan

Journal article  |  2012  |  Journal of Cell Biology

Cellular Up-regulation of Nedd4 Family Interacting Protein 1 (Ndfip1) using Low Levels of Bioactive Cobalt Complexes

Christine Schieber, Jason Howitt, Ulrich Putz, Jonathan M White, Clare L Parish, Paul S Donnelly, Seong-Seng Tan

Journal article  |  2011  |  Journal of Biological Chemistry

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons

Jason Howitt, Ulrich Putz, Jenny Lackovic, Anh Doan, Loretta Dorstyn, Hong Cheng, Baoli Yang, Chan-Ling Tailoi, John Silke, Sharad Kumar, Seong-Seng Tan

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

BDNF Exerts Contrasting Effects on Peripheral Myelination of NGF-Dependent and BDNF-Dependent DRG Neurons

Junhua Xiao, Agnes W Wong, Melanie M Willingham, Selma K Kaasinen, Ian A Hendry, Jason Howitt, Ulrich Putz, Graham L Barrett, Trevor J Kilpatrick, Simon S Murray

Journal article  |  2009  |  Journal of Neuroscience

Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins

Ulrich Putz, Jason Howitt, Jenny Lackovic, Natalie Foot, Sharad Kumar, John Silke, Seong-Seng Tan

Journal article  |  2008  |  Journal of Biological Chemistry

Structural and functional analysis of Slit and heparin binding to immunoglobulin-like domains 1 and 2 of Drosophila Robo

Noemi Fukuhara, Jason A Howitt, Sadaf-Ahmahni Hussain, Erhard Hohenester

Journal article  |  2008  |  Journal of Biological Chemistry

A molecular mechanism for the heparan sulfate dependence of Slit-Robo signaling

Sadaf-Ahmahni Hussain, Michael Piper, Noemi Fukuhara, Laure Strochlic, Gian Cho, Jason A Howitt, Yassir Ahmed, Andrew K Powell, Jeremy E Turnbull, Christine E Holt, Erhard Hohenester

Journal article  |  2006  |  Journal of Biological Chemistry

Interaction of the guidance molecule Slit with cellular receptors

E Hohenester, S Hussain, JA Howitt

Journal article  |  2006  |  Biochemical Society Transactions

Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of Slit

JA Howitt, NJ Clout, E Hohenester

Journal article  |  2004  |  The EMBO Journal

Protein aggregation during overexpression limited by peptide extensions with large net negative charge

YB Zhang, J Howitt, S McCorkle, P Lawrence, K Springer, P Freimuth

Journal article  |  2004  |  Protein Expression and Purification

Structural basis for variation in adenovirus affinity for the cellular coxsackievirus and adenovirus receptor

J Howitt, MC Bewley, V Graziano, JM Flanagan, P Freimuth

Journal article  |  2003  |  Journal of Biological Chemistry

Adenovirus interaction with its cellular receptor CAR

J Howitt, CW Anderson, P Freimuth

Book  |  2003  |  Current Topics in Microbiology and Immunology

Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor

YN He, PR Chipman, J Howitt, CM Bator, MA Whitt, TS Baker, RJ Kuhn, CW Anderson, P Freimuth, MG Rossmann

Journal article  |  2001  |  Nature Structural Biology