Ken Gayler

Discovery of Inhibitors of Lupin Diadenosine 5 ',5 '''-P-1,P-4-Tetraphosphate Hydrolase by Virtual Screening

Kim M Branson, Haydyn DT Mertens, James D Swarbrick, Jamie I Fletcher, Lukasz Kedzierski, Kenwyn R Gayler, Paul R Gooley, Brian J Smith

Journal article  |  2009  |  BIOCHEMISTRY

Novel inhibitors of lupin diadenosine 5',5'''-P(1),P(4)-tetraphosphate (Ap(4)A) hydrolase have been identified by in silico screen..

A Comprehensive Bioinformatics Analysis of the Nudix Superfamily in Arabidopsis thaliana

D Gunawardana, VA Likic, KR Gayler

Journal article  |  2009  |  COMPARATIVE AND FUNCTIONAL GENOMICS

Nudix enzymes are a superfamily with a conserved common reaction mechanism that provides the capacity for the hydrolysis of a broa..

Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2)

Dilantha Gunawardana, Heung-Chin Cheng, Kenwyn R Gayler

Journal article  |  2008  |  NUCLEIC ACIDS RESEARCH

The Arabidopsis thaliana decapping enzyme (AtDcp2) was characterized by bioinformatics analysis and by biochemical studies of the ..

Therapeutic applications of conotoxins that target the neuronal nicotinic acetylcholine receptor

Bruce G Livett, David W Sandall, David Keays, John Down, Ken R Gayler, Narmatha Satkunanathan, Zeinab Khalil

Journal article  |  2006  |  TOXICON

Pain therapeutics discovered by molecular mining of the expressed genome of Australian predatory cone snails are providing lead co..

Alpha-conotoxin Vc1.1 alleviates neuropathic pain and accelerates functional recovery of injured neurones

N Satkunanathan, B Livett, K Gayler, D Sandall, J Down, Z Khalil

Journal article  |  2005  |  BRAIN RESEARCH

This paper demonstrates the capacity of the neuronal nicotinic acetylcholine receptor (nAChR) antagonist alpha-conotoxin Vc1.1 to ..

Structure and substrate-binding mechanism of human Ap(4)A hydrolase

JD Swarbrick, S Buyya, D Gunawardana, KR Gayler, AG McLennan, PR Gooley

Journal article  |  2005  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Asymmetric diadenosine 5',5'''-P(1),P(4)-tetraphosphate (Ap(4)A) hydrolases play a major role in maintaining homeostasis by cleavi..

Molecular prospecting for drugs from the sea

K Gayler, D Sandall, D Greening, D Keays, M Polidano, B Livett, J Down, N Satkunanathan, Z Khalil

Journal article  |  2005  |  IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE

Molecular prospecting for drugs from the sea. Isolating therapeutic peptides and proteins from cone snail venom.

Ken Gayler, David Sandall, David Greening, David Keays, Megan Polidano, Bruce Livett, John Down, Narmatha Satkunanathan, Zeinab Khalil

Journal article  |  2005  |  IEEE Eng Med Biol Mag

Letter to the Editor: H-1, C-13, and N-15 resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP

JD Swarbrick, S Buyya, D Gunawardana, JI Fletcher, K Branson, B Smith, S Pepe, A McLennan, KR Gayler, PR Gooley

Journal article  |  2005  |  JOURNAL OF BIOMOLECULAR NMR

Drugs from the sea: Conopeptides as potential therapeutics

BG Livett, KR Gayler, Z Khalil

Journal article  |  2004  |  CURRENT MEDICINAL CHEMISTRY

Marine cone snails from the genus Conus are estimated to consist of up to 700 species. These predatory molluscs have devised an ef..