William Sawyer

Conformation and orientation of penetratin in phospholipid membranes

AHA Clayton, BW Atcliffe, GJ Howlett, WH Sawyer

Journal article  |  2006  |  JOURNAL OF PEPTIDE SCIENCE

The binding, conformation and orientation of a hydrophilic vector peptide penetratin in lipid membranes and its state of self-asso..

The membrane-binding properties of a class A amphipathic peptide.

H Mozsolits, T-H Lee, AHA Clayton, WH Sawyer, M-I Aguilar

Journal article  |  2004  |  Eur Biophys J

The membrane-binding properties of a class A amphipathic peptide (18D) were investigated using two different immobilized model mem..

The thiourea group modulates the fluorescence emission decay of fluorescein-labeled molecules

N Klonis, WH Sawyer

Journal article  |  2003  |  PHOTOCHEMISTRY AND PHOTOBIOLOGY

We have investigated the spectral properties and emission characteristics of fluorescein-5-thiocarbamoyl-N,N'-caproate (FITC-ACA) ..

Unfolding of class A amphipathic peptides on a lipid surface.

Andrew HA Clayton, Andra G Vultureanu, William H Sawyer

Journal article  |  2003  |  Biochemistry

The folding of polypeptides associated with biomembranes is a ubiquitous phenomenon, yet the thermodynamics underlying the process..

The central domain of Escherichia coli TyrR is responsible for hexamerization associated with tyrosine-mediated repression of gene expression

MP Dixon, RN Pau, GJ Howlett, DE Dunstan, WH Sawyer, BE Davidson

Journal article  |  2002  |  JOURNAL OF BIOLOGICAL CHEMISTRY

TyrR from Escherichia coli regulates the expression of genes for aromatic amino acid uptake and biosynthesis. Its central ATP-hydr..

Site-specific tryptophan fluorescence spectroscopy as a probe of membrane peptide structure and dynamics.

Andrew HA Clayton, William H Sawyer

Journal article  |  2002  |  Eur Biophys J

The fluorescence from tryptophan contains valuable information about the environment local to the indole side-chain. This environm..

Selective, high-affinity binding of ferric ions by glycine-extended gastrin(17)

GS Baldwin, CC Curtain, WH Sawyer

Journal article  |  2001  |  BIOCHEMISTRY

Uptake of dietary iron is essential for replenishment of body stores. A role for the hormone gastrin in iron uptake as a chelator ..

Independent movement of the regulatory and catalytic domains of myosin heads revealed by phosphorescence anisotropy

LJ Brown, N Klonis, WH Sawyer, PG Fajer, BD Hambly

Journal article  |  2001  |  BIOCHEMISTRY

Inter- and intradomain flexibility of the myosin head was measured using phosphorescence anisotropy of selectively labeled parts o..

Kinetics of membrane lysis by custom lytic peptides and peptide orientations in membrane

HM Chen, AHA Clayton, W Wang, WH Sawyer

Journal article  |  2001  |  EUROPEAN JOURNAL OF BIOCHEMISTRY

To aid the development of custom peptide antibiotics, a kinetic study of membrane lysis by cecropin B (CB) and its analogs, cecrop..