profile icon
A/Prof

Geoff Howlett

Honorary
Biochemistry and Pharmacology
Protein chemistry
science & technology
life sciences & biomedicine
biochemistry & molecular biology
humans
amyloid
apolipoprotein c-ii
kinetics
alzheimers-disease
Geoff Howlett's Profile Picture
A/Prof

Geoff Howlett

 
Division
Medicine, Dentistry and Health Sciences
 
Primary Interest
Physical Biochemistry
Geoff Howlett's Profile Picture
A/Prof

Geoff Howlett

 
Print
Geoff's  Short Profile
 

Find out more about Geoff Howlett's experience

Geoff Howlett's highlights

Projects

Displaying the 10 most recent projects by Geoff Howlett.

Project icon

Biophysical identification of natural human antibody targets

A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to ..

2010 - 2013
Completed
Project icon

Biophysical identification of natural human antibody targets

A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to ..

2010 - 2013
Completed
Project icon

PROTEIN SELF-ASSEMBLY ON SURFACES, INTERFACES AND NANOPARTICLES

Surfaces such as those presented by an air-liquid interface or air-borne nanoparticles exert significant effects on protein aggregation in b..

2009 - 2011
Completed
Project icon

Macromolecular Self-Assembly of Amyloid Fibrils

The misfolding of proteins is a key issue in public health. Common diseases, such as Alzheimer's disease, type 2 diabetes, and heart disease..

2008 - 2010
Completed
Project icon

Macromolecular Self-Assembly of Amyloid Fibrils

The misfolding of proteins is a key issue in public health. Common diseases, such as Alzheimer's disease, type 2 diabetes, and heart disease..

2008 - 2010
Completed
Project icon

STUDENT AGREEMENT FOR KATRINA BINGER - THE REVERSIBILITY OF AMYLOID FIBRIL FORMATION

2006 - 2009
Completed
Project icon

AMYLOID FORMATION

Project icon

The role of lipids in protein misfolding and amyloid-related diseases

Project icon

Protein-protein interactions in amyloid deposits

The aggregation of specific proteins to form insoluble amyloid fibrils is characteristic of several age-related diseases such as type-II dia..

Project icon

HIGH-SPEED ULTRACENTRIFUGE FACILITY WITH SENSITIVE SCANNING OPTICS FOR THE ANALYSIS OF INTERACTING BIOMOLECULES

This request is for a high-speed analytical ultracentrifuge equipped with sensitive absorbance, fluorescence, and interference scanning opti..

14

Projects

Project Types

9

Research Grant

3

Research Contracts

2

Internal Research Grant

Scholarly Works

Displaying the 10 most recent scholarly works by Geoff Howlett.

Scholarly works icon

Lipid-apolipoprotein interactions in amyloid fibril formation and relevance to atherosclerosis

Geoffrey J Howlett, Timothy M Ryan, Michael DW Griffin

Journal article  |  2019  |  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Scholarly works icon

Polymorphism in disease-related apolipoprotein C-II amyloid fibrils: a structural model for rod-like fibrils

Courtney O Zlatic, Yu Mao, Nevena Todorova, Yee-Foong Mok, Geoffrey J Howlett, Irene Yarovsky, Paul R Gooley, Michael DW Griffin

Journal article  |  2018  |  The FEBS Journal

Scholarly works icon

Intra- and Intersubunit Ion-Pair Interactions Determine the Ability of Apolipoprotein C-II Mutants To Form Hybrid Amyloid Fibrils.

Nevena Todorova, Courtney O Zlatic, Yu Mao, Irene Yarovsky, Geoffrey J Howlett, Paul R Gooley, Michael DW Griffin

Journal article  |  2017  |  Biochemistry

The apolipoprotein family is structurally defined by amphipathic α-helical regions that interact with lipid surfaces. In the absen..

Scholarly works icon

Intra- and Intersubunit Ion-Pair Interactions Determine the Ability of Apolipoprotein C-II Mutants To Form Hybrid Amyloid Fibrils

Nevena Todorova, Courtney O Zlatic, Yu Mao, Irene Yarovsky, Geoffrey J Howlett, Paul R Gooley, Michael DW Griffin

Journal article  |  2017  |  BIOCHEMISTRY

Scholarly works icon

Solution Conditions Affect the Ability of the K30D Mutation To Prevent Amyloid Fibril Formation by Apolipoprotein C-II: Insights from Experiments and Theoretical Simulations

Yu Mao, Nevena Todorova, Courtney O Zlatic, Paul R Gooley, Michael DW Griffin, Geoffrey J Howlett, Irene Yarovsky

Journal article  |  2016  |  Biochemistry

Scholarly works icon

Hydrogen/Deuterium Exchange and Molecular Dynamics Analysis of Amyloid Fibrils Formed by a D69K Charge-Pair Mutant of Human Apolipoprotein C-II

Yu Mao, Courtney O Zlatic, Michael DW Griffin, Geoffrey J Howlett, Nevena Todorova, Irene Yarovsky, Paul R Gooley

Journal article  |  2015  |  Biochemistry

Scholarly works icon

Chameleon 'aggregation-prone' segments of apoA-I: A model of amyloid fibrils formed in apoA-I amyloidosis

Nikolaos N Louros, Paraskevi L Tsiolaki, Michael DW Griffin, Geoffrey J Howlett, Stavros J Hamodrakas, Vassiliki A Iconomidou

Journal article  |  2015  |  International Journal of Biological Macromolecules

Scholarly works icon

Fluphenazine center dot HCl and Epigallocatechin Gal late Modulate the Rate of Formation and Structural Properties of Apolipoprotein C-II Amyloid Fibrils

Courtney O Zlatic, Yu Mao, Timothy M Ryan, Yee-Foong Mok, Blaine R Roberts, Geoffrey J Howlett, Michael DW Griffin

Journal article  |  2015  |  Biochemistry

Scholarly works icon

Charge and Charge-Pair Mutations Alter the Rate of Assembly and Structural Properties of Apolipoprotein C-II Amyloid Fibrils

Yu Mao, Chai Lean Teoh, Shuo Yang, Courtney O Zlatic, Zachary K Rosenes, Paul R Gooley, Geoffrey J Howlett, Michael DW Griffin

Journal article  |  2015  |  Biochemistry

Scholarly works icon

The Role of Lipid in Misfolding and Amyloid Fibril Formation by Apolipoprotein C-II

Timothy M Ryan, Yee-Foong Mok, Geoffrey J Howlett, Michael DW Griffin

Book Chapter  |  2015  |  Advances in Experimental Medicine and Biology

84

Scholarly Works

Keyword Analysis

Biochemistry and Cell Biology
Non-Oriented Research
Expanding Knowledge
Other Health
Medicinal and Biomolecular Chemistry
Macromolecular Chemistry
Clinical (organs, Diseases and Abnormal Conditions)
Clinical Health (organs, Diseases and Abnormal Conditions)
Medical Biochemistry and Clinical Chemistry
Analytical Chemistry

Credentials

Positions

Honorary

Biochemistry and Pharmacology

Ordinary Member

Australian Society for Biochemistry and Molecular Biology

Education

Doctor of Philosophy

University of Melbourne

Bachelor of Science (honours)

University of Melbourne