Geoff Howlett

Lipid-apolipoprotein interactions in amyloid fibril formation and relevance to atherosclerosis

Geoffrey J Howlett, Timothy M Ryan, Michael DW Griffin

Journal article  |  2019  |  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The apolipoprotein family is a set of highly conserved proteins characterized by the presence of amphipathic α-helical sequences t..

Polymorphism in disease-related apolipoprotein C-II amyloid fibrils: a structural model for rod-like fibrils

Courtney O Zlatic, Yu Mao, Nevena Todorova, Yee-Foong Mok, Geoffrey J Howlett, Irene Yarovsky, Paul R Gooley, Michael DW Griffin

Journal article  |  2018  |  FEBS JOURNAL

Human apolipoprotein (apo) C-II is one of several plasma apolipoproteins that form amyloid deposits in vivo and is an independent ..

Intra- and Intersubunit Ion-Pair Interactions Determine the Ability of Apolipoprotein C-II Mutants To Form Hybrid Amyloid Fibrils.

Nevena Todorova, Courtney O Zlatic, Yu Mao, Irene Yarovsky, Geoffrey J Howlett, Paul R Gooley, Michael DW Griffin

Journal article  |  2017  |  Biochemistry

The apolipoprotein family is structurally defined by amphipathic α-helical regions that interact with lipid surfaces. In the absen..

Intra- and Intersubunit Ion-Pair Interactions Determine the Ability of Apolipoprotein C-II Mutants To Form Hybrid Amyloid Fibrils

Nevena Todorova, Courtney O Zlatic, Yu Mao, Irene Yarovsky, Geoffrey J Howlett, Paul R Gooley, Michael DW Griffin

Journal article  |  2017  |  BIOCHEMISTRY

Solution Conditions Affect the Ability of the K30D Mutation To Prevent Amyloid Fibril Formation by Apolipoprotein C-II: Insights from Experiments and Theoretical Simulations

Yu Mao, Nevena Todorova, Courtney O Zlatic, Paul R Gooley, Michael DW Griffin, Geoffrey J Howlett, Irene Yarovsky

Journal article  |  2016  |  BIOCHEMISTRY

Apolipoproteins form amphipathic helical structures that bind lipid surfaces. Paradoxically, lipid-free apolipoproteins display a ..

Hydrogen/Deuterium Exchange and Molecular Dynamics Analysis of Amyloid Fibrils Formed by a D69K Charge-Pair Mutant of Human Apolipoprotein C-II

Yu Mao, Courtney O Zlatic, Michael DW Griffin, Geoffrey J Howlett, Nevena Todorova, Irene Yarovsky, Paul R Gooley

Journal article  |  2015  |  BIOCHEMISTRY

Plasma apolipoproteins form amphipathic α helices in lipid environments but in the lipid-free state show a high propensity to form..

Chameleon 'aggregation-prone' segments of apoA-I: A model of amyloid fibrils formed in apoA-I amyloidosis

Nikolaos N Louros, Paraskevi L Tsiolaki, Michael DW Griffin, Geoffrey J Howlett, Stavros J Hamodrakas, Vassiliki A Iconomidou

Journal article  |  2015  |  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Apolipoprotein A-I (apoA-I) is the major component of high density lipoproteins and plays a vital role in reverse cholesterol tran..

Fluphenazine center dot HCl and Epigallocatechin Gal late Modulate the Rate of Formation and Structural Properties of Apolipoprotein C-II Amyloid Fibrils

Courtney O Zlatic, Yu Mao, Timothy M Ryan, Yee-Foong Mok, Blaine R Roberts, Geoffrey J Howlett, Michael DW Griffin

Journal article  |  2015  |  BIOCHEMISTRY

Protein misfolding and aggregation, leading to amyloid fibril formation, are characteristic of many devastating and debilitating a..

Charge and Charge-Pair Mutations Alter the Rate of Assembly and Structural Properties of Apolipoprotein C-II Amyloid Fibrils

Yu Mao, Chai Lean Teoh, Shuo Yang, Courtney O Zlatic, Zachary K Rosenes, Paul R Gooley, Geoffrey J Howlett, Michael DW Griffin

Journal article  |  2015  |  BIOCHEMISTRY

The misfolding, aggregation, and accumulation of proteins as amyloid fibrils is a defining characteristic of several debilitating ..

The Role of Lipid in Misfolding and Amyloid Fibril Formation by Apolipoprotein C-II

Timothy M Ryan, Yee-Foong Mok, Geoffrey J Howlett, Michael DW Griffin

Book Chapter  |  2015  |  Advances in Experimental Medicine and Biology

Apolipoproteins are a key component of lipid transport in the circulatory system and share a number of structural features that fa..