Lorena Brown

Immune profiling of influenza-specific B- and T-cell responses in macaques using flow cytometry-based assays

Marios Koutsakos, Toshiki Sekiya, Brendon Y Chua, Hoang Oanh Nguyen Thi, Adam K Wheatley, Jennifer A Juno, Marumi Ohno, Naoki Nomura, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Saori Suzuki, Hirohito Ishigaki, Misako Nakayama, Cong T Nguyen, Yasushi Itoh, Masashi Shingai, Kazumasa Ogasawara, Yoichiro Kino, Stephen J Kent, et al.

Journal article  |  2020  |  Immunology and Cell Biology

Influenza remains a significant global public health burden, despite substantial annual vaccination efforts against circulating vi..

The structure of the influenza A virus genome

Bernadeta Dadonaite, Brad Gilbertson, Michael L Knight, Sanja Trifkovic, Steven Rockman, Alain Laederach, Lorena E Brown, Ervin Fodor, David LV Bauer

Journal article  |  2019  |  Nature Microbiology

Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA s..

Insights into the Acquisition of Virulence of Avian Influenza Viruses during a Single Passage in Ferrets

Jeffrey Butler, Deborah Middleton, Jessica Haining, Rachel Layton, Steven Rockman, Lorena E Brown, Sandra Sapats

Journal article  |  2019  |  Viruses

Circulating avian influenza viruses pose a significant threat, with human infections occurring infrequently but with potentially s..

Inhibition of Influenza A Virus by Human Infant Saliva

Brad Gilbertson, Kathryn Edenborough, Jodie McVernon, Lorena E Brown

Journal article  |  2019  |  Viruses

Topical application of human-derived Ig isotypes for the control of acute respiratory infection evaluated in a human CD89-expressing mouse model

Sandra Koernig, Ian K Campbell, Charley Mackenzie-Kludas, Alexander Schaub, Marius Loetscher, Wy Ching Ng, Roland Zehnder, Pawel Pelczar, Ildem Sanli, Monther Alhamdoosh, Milica Ng, Lorena E Brown, Fabian Kasermann, Cedric Vonarburg, Adrian W Zuercher

Journal article  |  2019  |  Mucosal Immunology

Inactivated whole virus particle vaccine with potent immunogenicity and limited IL-6 induction is ideal for influenza

Toshiki Sekiya, Edin J Mifsud, Marumi Ohno, Naoki Nomura, Mayumi Sasada, Daisuke Fujikura, Takuji Daito, Masashi Shingai, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Ryotarou Mitsumata, Tomio Ikeda, Hironori Hatanaka, Hiroki Kitayama, Kenji Motokawa, Tomoyoshi Sobue, Saori Suzuki, Yasushi Itoh, Lorena E Brown, et al.

Journal article  |  2019  |  Vaccine

Influenza Virus Neuraminidase Structure and Functions

Julie L McAuley, Brad P Gilbertson, Sanja Trifkovic, Lorena E Brown, Jennifer L McKimm-Breschkin

Journal article  |  2019  |  Frontiers in Microbiology

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8( ) T cells more relevant to current infections

D Korenkov, THO Nguyen, I Isakova-Sivak, T Smolonogina, LE Brown, K Kedzierska, L Rudenko

Journal article  |  2018  |  Human Vaccines & Immunotherapeutics

The cell surface mucin MUC1 limits the severity of influenza A virus infection

JL McAuley, L Corcilius, H-X Tan, RJ Payne, MA McGuckin, LE Brown

Journal article  |  2017  |  Mucosal Immunology

Extrinsically derived TNF is primarily responsible for limiting antiviral CD8 T cell response magnitude

Kylie M Quinn, Wan-Ting Kan, Katherine A Watson, Brian J Liddicoat, Natasha G Swan, Hayley McQuilten, Alice E Denton, Jasmine Li, Weisan Chen, Lorena E Brown, David C Jackson, Patrick C Reading, Peter C Doherty, Katherine Kedzierska, Lukasz Kedzierski, Stephen J Turner, Nicole L La Gruta

Journal article  |  2017  |  PLoS One