Lorena Brown

Gene Segment Interactions Can Drive the Emergence of Dominant Yet Suboptimal Gene Constellations During Influenza Virus Reassortment

Sanja Trifkovic, Brad Gilbertson, Emily Fairmaid, Joanna Cobbin, Steven Rockman, Lorena EE Brown

Journal article  |  2021  |  FRONTIERS IN MICROBIOLOGY

A segmented genome enables influenza virus to undergo reassortment when two viruses infect the same cell. Although reassortment is..

Potent priming by inactivated whole influenza virus particle vaccines is linked to viral RNA uptake into antigen presenting cells

Masashi Shingai, Naoki Nomura, Toshiki Sekiya, Marumi Ohno, Daisuke Fujikura, Chimuka Handabile, Ryosuke Omori, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Kazuhiko Kimachi, Ryotarou Mitsumata, Tomio Ikeda, Hiroki Kitayama, Hironori Hatanaka, Tomoyoshi Sobue, Fumihito Muro, Saori Suzuki, Cong Thanh Nguyen, Hirohito Ishigaki, et al.

Journal article  |  2021  |  VACCINE

Current detergent or ether-disrupted split vaccines (SVs) for influenza do not always induce adequate immune responses, especially..

Selecting and Using the Appropriate Influenza Vaccine for Each Individual

Toshiki Sekiya, Marumi Ohno, Naoki Nomura, Chimuka Handabile, Masashi Shingai, David C Jackson, Lorena E Brown, Hiroshi Kida

Journal article  |  2021  |  VIRUSES-BASEL

Despite seasonal influenza vaccines having been routinely used for many decades, influenza A virus continues to pose a global thre..

Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients

Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Jeremy Chase Crawford, Liyen Loh, Sneha Sant, Ludivine Grzelak, Emma K Allen, Tim Brahm, E Bridie Clemens, Maria Auladell, Luca Hensen, Zhongfang Wang, Simone Nussing, Xiaoxiao Jia, Patrick Gunther, Adam K Wheatley, Stephen J Kent, Malet Aban, Yi-Mo Deng, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one singl..

TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua

Journal article  |  2021  |  JCI INSIGHT

The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections po..

Immune profiling of influenza-specific B- and T-cell responses in macaques using flow cytometry-based assays

Marios Koutsakos, Toshiki Sekiya, Brendon Y Chua, Hoang Oanh Nguyen Thi, Adam K Wheatley, Jennifer A Juno, Marumi Ohno, Naoki Nomura, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Saori Suzuki, Hirohito Ishigaki, Misako Nakayama, Cong T Nguyen, Yasushi Itoh, Masashi Shingai, Kazumasa Ogasawara, Yoichiro Kino, Stephen J Kent, et al.

Journal article  |  2020  |  IMMUNOLOGY AND CELL BIOLOGY

Influenza remains a significant global public health burden, despite substantial annual vaccination efforts against circulating vi..

The structure of the influenza A virus genome

Bernadeta Dadonaite, Brad Gilbertson, Michael L Knight, Sanja Trifkovic, Steven Rockman, Alain Laederach, Lorena E Brown, Ervin Fodor, David LV Bauer

Journal article  |  2019  |  NATURE MICROBIOLOGY

Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA s..

Insights into the Acquisition of Virulence of Avian Influenza Viruses during a Single Passage in Ferrets

Jeffrey Butler, Deborah Middleton, Jessica Haining, Rachel Layton, Steven Rockman, Lorena E Brown, Sandra Sapats

Journal article  |  2019  |  VIRUSES-BASEL

Circulating avian influenza viruses pose a significant threat, with human infections occurring infrequently but with potentially s..

Inhibition of Influenza A Virus by Human Infant Saliva

Brad Gilbertson, Kathryn Edenborough, Jodie McVernon, Lorena E Brown

Journal article  |  2019  |  VIRUSES-BASEL

Innate antiviral factors in saliva play a role in protection against respiratory infections. We tested the anti-influenza virus ac..

Topical application of human-derived Ig isotypes for the control of acute respiratory infection evaluated in a human CD89-expressing mouse model

Sandra Koernig, Ian K Campbell, Charley Mackenzie-Kludas, Alexander Schaub, Marius Loetscher, Wy Ching Ng, Roland Zehnder, Pawel Pelczar, Ildem Sanli, Monther Alhamdoosh, Milica Ng, Lorena E Brown, Fabian Kasermann, Cedric Vonarburg, Adrian W Zuercher

Journal article  |  2019  |  MUCOSAL IMMUNOLOGY

Recurrent and persistent airway infections remain prevalent in patients with primary immunodeficiency (PID), despite restoration o..