David Jackson

The endogenous inflammatory reflex inhibits the inflammatory response to different immune challenges in mice.

Alessandra Occhinegro, Chinn Yi Wong, Brendon Y Chua, David C Jackson, Michael J McKinley, Robin M McAllen, Davide Martelli

Journal article  |  2021  |  Brain Behav Immun

The splanchnic anti-inflammatory pathway, the efferent arm of the endogenous inflammatory reflex, has been shown to suppress the a..

TLR2-mediated innate immune priming boosts lung anti-viral immunity

Jason Girkin, Su-Ling Loo, Camille Esneau, Steven Maltby, Francesca Mercuri, Brendon Chua, Andrew T Reid, Punnam Chander Veerati, Chris L Grainge, Peter AB Wark, Darryl Knight, David Jackson, Christophe Demaison, Nathan W Bartlett

Journal article  |  2021  |  EUROPEAN RESPIRATORY JOURNAL

BACKGROUND: We assessed whether Toll-like receptor (TLR)2 activation boosts the innate immune response to rhinovirus infection, as..

Potent priming by inactivated whole influenza virus particle vaccines is linked to viral RNA uptake into antigen presenting cells

Masashi Shingai, Naoki Nomura, Toshiki Sekiya, Marumi Ohno, Daisuke Fujikura, Chimuka Handabile, Ryosuke Omori, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Kazuhiko Kimachi, Ryotarou Mitsumata, Tomio Ikeda, Hiroki Kitayama, Hironori Hatanaka, Tomoyoshi Sobue, Fumihito Muro, Saori Suzuki, Cong Thanh Nguyen, Hirohito Ishigaki, et al.

Journal article  |  2021  |  VACCINE

Current detergent or ether-disrupted split vaccines (SVs) for influenza do not always induce adequate immune responses, especially..

Selecting and Using the Appropriate Influenza Vaccine for Each Individual

Toshiki Sekiya, Marumi Ohno, Naoki Nomura, Chimuka Handabile, Masashi Shingai, David C Jackson, Lorena E Brown, Hiroshi Kida

Journal article  |  2021  |  VIRUSES-BASEL

Despite seasonal influenza vaccines having been routinely used for many decades, influenza A virus continues to pose a global thre..

CD8( ) T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

Luca Hensen, Patricia T Illing, E Bridie Clemens, Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Nicole A Mifsud, Andrea T Nguyen, Christopher Szeto, Brendon Y Chua, Hanim Halim, Simone Rizzetto, Fabio Luciani, Liyen Loh, Emma J Grant, Phillipa M Saunders, Andrew G Brooks, Steve Rockman, Tom C Kotsimbos, Allen C Cheng, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indig..

Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients

Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Jeremy Chase Crawford, Liyen Loh, Sneha Sant, Ludivine Grzelak, Emma K Allen, Tim Brahm, E Bridie Clemens, Maria Auladell, Luca Hensen, Zhongfang Wang, Simone Nussing, Xiaoxiao Jia, Patrick Gunther, Adam K Wheatley, Stephen J Kent, Malet Aban, Yi-Mo Deng, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one singl..

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Kevin J Selva, Carolien E van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Brendon Y Chua, Samantha K Davis, Thi HO Nguyen, Louise C Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C Jackson, Katie L Flanagan, Jane Crowe, Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul Licciardi, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-..

Pre-existing influenza-specific nasal IgA or nasal viral infection does not affect live attenuated influenza vaccine immunogenicity in children.

ME Cole, R Kundu, AF Abdulla, N Andrews, K Hoschler, J Southern, D Jackson, E Miller, M Zambon, PJ Turner, JS Tregoning

Journal article  |  2021  |  Clin Exp Immunol

The United Kingdom has a national immunization programme which includes annual influenza vaccination in school-aged children, usin..

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

Marios Koutsakos, Louise C Rowntree, Luca Hensen, Brendon Y Chua, Carolien E van de Sandt, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lukasz Kedzierski, Thomas M Ashhurst, Givanna H Putri, Felix Marsh-Wakefield, Mark N Read, Davis N Edwards, E Bridie Clemens, Chinn Yi Wong, Francesca L Mordant, Jennifer A Juno, Fatima Amanat, Jennifer Audsley, et al.

Journal article  |  2021  |  CELL REPORTS MEDICINE

SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-..

TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua

Journal article  |  2021  |  JCI INSIGHT

The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections po..