David Jackson

Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques

Brendon Y Chua, Toshiki Sekiya, Marios Koutsakos, Naoki Nomura, Louise C Rowntree, Thi HO Nguyen, Hayley A McQuilten, Marumi Ohno, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Yasushi Itoh, Jennifer R Habel, Kevin J Selva, Adam K Wheatley, Bruce D Wines, P Mark Hogarth, Stephen J Kent, Amy W Chung, David C Jackson, et al.

Journal article  |  2022  |  PLOS PATHOGENS

Although antibody-inducing split virus vaccines (SV) are currently the most effective way to combat seasonal influenza, their effi..

Abstract 3502: AXA-042 - a novel systemic TLR2/6 agonist for anti-tumor therapy

Anna V Galkin, Francesca Mercuri, Nicholas West, Ping Zhang, Weiguang Zeng, Grant McLachlan, Michael Bettess, Ian Holmes, David Jackson, Chris Smith, Christophe Demaison, Tobias Bald, Phil Kearney

Journal article  |  2022  |  Cancer Research

Abstract Background: Treatment approaches that engage both the innate and adaptive immune response have the potenti..

Nonhuman primate models for evaluation of SARS-CoV-2 vaccines

Jessica A Neil, Maryanne Griffith, Dale I Godfrey, Damian FJ Purcell, Georgia Deliyannis, David Jackson, Steve Rockman, Kanta Subbarao, Terry Nolan

Journal article  |  2022  |  EXPERT REVIEW OF VACCINES

INTRODUCTION: Evaluation of immunogenicity and efficacy in animal models provide critical data in vaccine development. Nonhuman pr..

Air-Liquid-Interface Differentiated Human Nose Epithelium: A Robust Primary Tissue Culture Model of SARS-CoV-2 Infection

Bang M Tran, Samantha L Grimley, Julie L McAuley, Abderrahman Hachani, Linda Earnest, Sharon L Wong, Leon Caly, Julian Druce, Damian FJ Purcell, David C Jackson, Mike Catton, Cameron J Nowell, Laura Leonie, Georgia Deliyannis, Shafagh A Waters, Joseph Torresi, Elizabeth Vincan

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The global urgency to uncover medical countermeasures to combat the COVID-19 pandemic caused by the severe acute respiratory syndr..

The endogenous inflammatory reflex inhibits the inflammatory response to different immune challenges in mice

Alessandra Occhinegro, Chinn Yi Wong, Brendon Y Chua, David C Jackson, Michael J McKinley, Robin M McAllen, Davide Martelli

Journal article  |  2021  |  BRAIN BEHAVIOR AND IMMUNITY

The splanchnic anti-inflammatory pathway, the efferent arm of the endogenous inflammatory reflex, has been shown to suppress the a..

TLR2-mediated innate immune priming boosts lung anti-viral immunity

Jason Girkin, Su-Ling Loo, Camille Esneau, Steven Maltby, Francesca Mercuri, Brendon Chua, Andrew T Reid, Punnam Chander Veerati, Chris L Grainge, Peter AB Wark, Darryl Knight, David Jackson, Christophe Demaison, Nathan W Bartlett

Journal article  |  2021  |  EUROPEAN RESPIRATORY JOURNAL

BACKGROUND: We assessed whether Toll-like receptor (TLR)2 activation boosts the innate immune response to rhinovirus infection, as..

Potent priming by inactivated whole influenza virus particle vaccines is linked to viral RNA uptake into antigen presenting cells

Masashi Shingai, Naoki Nomura, Toshiki Sekiya, Marumi Ohno, Daisuke Fujikura, Chimuka Handabile, Ryosuke Omori, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Kazuhiko Kimachi, Ryotarou Mitsumata, Tomio Ikeda, Hiroki Kitayama, Hironori Hatanaka, Tomoyoshi Sobue, Fumihito Muro, Saori Suzuki, Cong Thanh Nguyen, Hirohito Ishigaki, et al.

Journal article  |  2021  |  VACCINE

Current detergent or ether-disrupted split vaccines (SVs) for influenza do not always induce adequate immune responses, especially..

Selecting and Using the Appropriate Influenza Vaccine for Each Individual

Toshiki Sekiya, Marumi Ohno, Naoki Nomura, Chimuka Handabile, Masashi Shingai, David C Jackson, Lorena E Brown, Hiroshi Kida

Journal article  |  2021  |  VIRUSES-BASEL

Despite seasonal influenza vaccines having been routinely used for many decades, influenza A virus continues to pose a global thre..

CD8( ) T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

Luca Hensen, Patricia T Illing, E Bridie Clemens, Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Nicole A Mifsud, Andrea T Nguyen, Christopher Szeto, Brendon Y Chua, Hanim Halim, Simone Rizzetto, Fabio Luciani, Liyen Loh, Emma J Grant, Phillipa M Saunders, Andrew G Brooks, Steve Rockman, Tom C Kotsimbos, Allen C Cheng, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indig..

Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients

Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Jeremy Chase Crawford, Liyen Loh, Sneha Sant, Ludivine Grzelak, Emma K Allen, Tim Brahm, E Bridie Clemens, Maria Auladell, Luca Hensen, Zhongfang Wang, Simone Nussing, Xiaoxiao Jia, Patrick Gunther, Adam K Wheatley, Stephen J Kent, Malet Aban, Yi-Mo Deng, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one singl..