Peter Wookey

Calcitonin receptor antibody validation and expression in the rodent brain.

Erica R Hendrikse, Tayla A Rees, Zoe Tasma, Christelle Le Foll, Thomas A Lutz, Andrew Siow, Peter J Wookey, Christopher S Walker, Debbie L Hay

Journal article  |  2022  |  Cephalalgia

BACKGROUND AND AIM: Therapeutics that reduce calcitonin gene-related peptide activity are effective migraine treatments. However, ..

Splice Variants of G Protein-Coupled Receptors Expressed in Cancers: Effective Targeting with Monoclonal Antibodies and Antibody-Like Scaffolds As Ligands Irrespective of the Pharmacological Status of Isoforms

PJ Wookey, P Gupta, DL Hare, GD Ciccotosto, CJ Hutchings

Book Chapter  |  2022

Strategic Development of an Immunotoxin for the Treatment of Glioblastoma and Other Tumours Expressing the Calcitonin Receptor

Pragya Gupta, David L Hare, Peter J Wookey

Journal article  |  2021  |  CELLS

New strategies aimed at treatment of glioblastoma are frequently proposed to overcome poor prognosis. Recently, research has focus..

Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy.

Peter Wookey, Pragya Gupta, Lucas Bittencourt, Shane Cheung, David Hare, Sebastian Furness

Journal article  |  2021  |  F1000Res

The expression of the calcitonin receptor (CT Receptor) is widespread throughout the life cycle of mammals and in many diseases, a..

Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma

Pragya Gupta, Sebastian GB Furness, Lucas Bittencourt, David L Hare, Peter J Wookey

Journal article  |  2020  |  THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY

Researchers are actively seeking novel targeted therapies for the brain tumour glioblastoma (GBM) as the mean survival is less tha..

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Anna Ostrovskaya, Caroline Hick, Dana S Hutchinson, Brett W Stringer, Peter J Wookey, Denise Wootten, Patrick M Sexton, Sebastian GB Furness

Journal article  |  2019  |  BMC CANCER

BACKGROUND: Glioblastoma (GBM) is the most common and aggressive type of primary brain cancer. With median survival of less than 1..

Calcitonin receptor expression in medullary thyroid carcinoma

Virginia Cappagli, Catarina Soares Potes, Luciana Bueno Ferreira, Catarina Tavares, Catarina Eloy, Rossella Elisei, Manuel Sobrinho-Simoes, Peter J Wookey, Paula Soares

Journal article  |  2017  |  PEERJ

BACKGROUND: Calcitonin expression is a well-established marker for medullary thyroid carcinoma (MTC); yet the role of calcitonin r..

Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma

Roger Gilabert-Oriol, Sebastian GB Furness, Brett W Stringer, Alexander Weng, Hendrik Fuchs, Bryan W Day, Angela Kourakis, Andrew W Boyd, David L Hare, Mayank Thakur, Terrance G Johns, Peter J Wookey

Journal article  |  2017  |  CANCER IMMUNOLOGY IMMUNOTHERAPY

We have reported that calcitonin receptor (CTR) is widely expressed in biopsies from the lethal brain tumour glioblastoma by malig..

Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy

Sebastian George Barton Furness, Yi-Lynn Liang, Cameron James Nowell, Michelle Louise Halls, Peter John Wookey, Emma Dal Maso, Asuka Inoue, Arthur Christopoulos, Denise Wootten, Patrick Michael Sexton

Journal article  |  2016  |  CELL

G protein-coupled receptor (GPCR) signaling, mediated by hetero-trimeric G proteins, can be differentially controlled by agonists...

A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death

SGB Furness, DL Hare, A Kourakis, AM Turnley, PJ Wookey

Journal article  |  2016  |  CELL DEATH DISCOVERY

We have discovered that the accumulation of an anti-calcitonin receptor (anti-CTR) antibody conjugated to a fluorophore (mAb2C4:AF..