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Dr

Peter Wookey

Honorary
Medicine - Austin Health
calcitonin receptor as target
Novel detector of PCD
Antibodies to GPCRs
glioblastoma
Development of immunotoxins
cardiovascular disease
Neural networks and calcitonin receptor
science & technology
life sciences & biomedicine
Peter Wookey's Profile Picture
Dr

Peter Wookey

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Brain tumour
Peter Wookey's Profile Picture
Dr

Peter Wookey

 

Dr Peter Wookey is a biochemist/cell biologist and received his PhD from the ANU, Canberra.He was a postdoc in Germany (Alexander von Humboldt Stiftung), Microbiology-University of Melbourne (UoM), Walter & Eliza Hall Institute and Medicine-UoM. During the period 2005 to the present, he has been a Senior Fellow (honorary) in the Department of Medicine, UoM, Austin Health, where he is research director for the cardio- & tumouro-vascular research group, co-managed with Professor David L Hare. Dr Wookey has generated several classes of unique monoclonal antibodies against G protein-coupled receptors including rodent calcitonin receptor (CTR), human CTR, human CLR, human NPY1R and other receptor targets on human and murine FLVCR2.

There are several subclasses of anti-human CTR based on the targeted epitopes in the extracellular (first in class) and intracellular domains as well as an isoform specific epitope. The anti-CTR antibodies have been successfully deployed for studies on brain neuro-circuits, cardiovascular disease, leukaemia, skeletal muscle satellite stem cells, myeloma, thyroid carcinomas and the brain tumour glioblastoma. Due to the unique nature of the anti-epitope 4 human CTR antibodies that bind to live cells and their potential application for treatment of diseases and detection of programmed cell death, these became the subject of two granted patent classes.

Ongoing collaborations include, Dr Sebastian GB Furness (ARC Future Fellow, Monash University) and Professor Hendrik Fuchs (Charité Universität-Medizin Berlin) with whom we also have a funded exchange program.

Currently our group includes Dr Lucas Bittencourt (UoM postdoctoral Visitor) and PhD student Pragya Gupta, with further students interested in studying with our group in 2021.

Dr Wookey has a keen interest in both basic biology and translational research, and registered a startup company Welcome Receptor Antibodies (WRA) in 2005 for the latter purpose. The company was granted two patents and awarded a grant from Commercialisation Australia in 2014 to develop proof of concept for the market for CalRexin, which is the trademark of the unique anti-human CTR antibody that binds the extracellular epitope.

In 2016 Dr Wookey registered a spin-off company Apop Imaging (renamed Apop Biosciences) to commercialise research related to CalRexin for the benefit of the wider (global) community. His role is executive director and chief scientific officer since February 2018. Apop Biosciences has a Board, management team and investors. The first product is CalRexin:568 which can be used to monitor apoptosis and possibly autophagy in live cell assays. A pipeline product is the immunotoxin based on Calrexin and the subject of the collaboration with Prof Fuchs, Berlin.

Recently Dr Wookey has proposed a novel hypothesis that proposes an isoform of CTR which previously had orphan status, functions in an efflux mechanism for cytotoxic material in parallel with autophagic mechanisms in stressed cells and is important as a mechanism that confers drug resistance in cancers.

Throughout he has been fortunate to have enjoyed the support of his partner Jing and two offspring Alice and Oscar.

Scholarly Works

Displaying the 10 most recent scholarly works by Peter Wookey.

Honours, Awards and Fellowships

1978

Post doctoral award for research studies

Alexander von Humboldt Stiftung

1

Award

Credentials

Positions

Positions


Honorary

Medicine - Austin Health

Ordinary Member

American Association for the Advancement fo Science

Education

Education


NOT IN LIST

Eberhard-Karls-Universitaet Tuebingen

Doctor of Philosophy

Australian National University

Bachelor of Science (Honours)

Australian National University