Geoffrey Pietersz

A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein

Johannes Zeller, Karen S Cheung Tung Shing, Tracy L Nero, James D McFadyen, Guy Krippner, Balazs Bogner, Sheena Kreuzaler, Jurij Kiefer, Verena K Horner, David Braig, Habiba Danish, Sara Baratchi, Mark Fricke, Xiaowei Wang, Michel G Kather, Bernd Kammerer, Kevin J Woollard, Prerna Sharma, Craig J Morton, Geoffrey Pietersz, et al.

Journal article  |  2022  |  EMBO MOLECULAR MEDICINE

C-reactive protein (CRP) is an early-stage acute phase protein and highly upregulated in response to inflammatory reactions. We re..

Activated Platelet-Targeted IR780 Immunoliposomes for Photothermal Thrombolysis

Ahmed Refaat, Blanca del Rosal, Viktoria Bongcaron, Aidan PG Walsh, Geoffrey Pietersz, Karlheinz Peter, Simon E Moulton, Xiaowei Wang

Journal article  |  2022  |  ADVANCED FUNCTIONAL MATERIALS

Acute thrombosis is a leading cause of mortality and morbidity worldwide. Pharmacological thrombolysis relies on plasminogen activ..

Immunotherapy for cancer-toxin-antibody conjugates

G Pietersz, I McKenzie

Book Chapter  |  2022

In vivo fluorescence imaging: success in preclinical imaging paves the way for clinical applications

Ahmed Refaat, May Lin Yap, Geoffrey Pietersz, Aidan Patrick Garing Walsh, Johannes Zeller, Blanca del Rosal, Xiaowei Wang, Karlheinz Peter

Journal article  |  2022  |  JOURNAL OF NANOBIOTECHNOLOGY

Advances in diagnostic imaging have provided unprecedented opportunities to detect diseases at early stages and with high reliabil..

Two-Dimensional and Three-Dimensional Time-of-Flight Secondary Ion Mass Spectrometry Image Feature Extraction Using a Spatially Aware Convolutional Autoencoder.

Wil Gardner, David A Winkler, Suzanne M Cutts, Steven A Torney, Geoffrey A Pietersz, Benjamin W Muir, Paul J Pigram

Journal article  |  2022  |  Anal Chem

Feature extraction algorithms are an important class of unsupervised methods used to reduce data dimensionality. They have been ap..

Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases

J Zeller, B Bogner, JD McFadyen, J Kiefer, D Braig, G Pietersz, G Krippner, TL Nero, CJ Morton, KS Cheung Tung Shing, MW Parker, K Peter, SU Eisenhardt

Journal article  |  2022  |  PHARMACOLOGY & THERAPEUTICS

C-reactive protein (CRP) is the prototypic acute-phase reactant that has long been recognized almost exclusively as a marker of in..

Nanobiotechnology approaches for cardiovascular diseases: site-specific targeting of drugs and nanoparticles for atherothrombosis

Haikun Liu, Geoffrey Pietersz, Karlheinz Peter, Xiaowei Wang

Journal article  |  2022  |  JOURNAL OF NANOBIOTECHNOLOGY

Atherosclerosis and atherothrombosis, the major contributors to cardiovascular diseases (CVDs), represent the leading cause of dea..

Fc Binding by Fc gamma RIIa Is Essential for Cellular Activation by the Anti-Fc gamma RIIa mAbs 8.26 and 8.2

Bruce D Wines, Halina M Trist, Sandra Esparon, Rachael E Impey, Graham A Mackay, Robert K Andrews, Tatiana P Soares da Costa, Geoffrey A Pietersz, Ross Baker, P Mark Hogarth

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

FcγR activity underpins the role of antibodies in both protective immunity and auto-immunity and importantly, the therapeutic acti..

Near-infrared light-responsive liposomes for protein delivery: Towards bleeding-free photothermally-assisted thrombolysis

Ahmed Refaat, Blanca del Rosal, Jathushan Palasubramaniam, Geoffrey Pietersz, Xiaowei Wang, Simon E Moulton, Karlheinz Peter

Journal article  |  2021  |  JOURNAL OF CONTROLLED RELEASE

Smart drug delivery systems represent state-of-the-art approaches for targeted therapy of life-threatening diseases such as cancer..

Smart Delivery of Plasminogen Activators for Efficient Thrombolysis; Recent Trends and Future Perspectives

Ahmed Refaat, Blanca del Rosal, Jathushan Palasubramaniam, Geoffrey Pietersz, Xiaowei Wang, Karlheinz Peter, Simon E Moulton

Journal article  |  2021  |  ADVANCED THERAPEUTICS

Fibrinolytic drugs have been successfully used to manage acute thrombotic and thromboembolic conditions. However, their narrow adm..