Alastair Stewart

Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies.

Suowen Xu, Iqra Ilyas, Peter J Little, Hong Li, Danielle Kamato, Xueying Zheng, Sihui Luo, Zhuoming Li, Peiqing Liu, Jihong Han, Ian C Harding, Eno E Ebong, Scott J Cameron, Alastair G Stewart, Jianping Weng

Journal article  |  2021  |  Pharmacol Rev

The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in maintaining multiorgan health and hom..

High-throughput microfluidic compressibility cytometry using multi-tilted-angle surface acoustic wave

Yanqi Wu, Alastair G Stewart, Peter VS Lee

Journal article  |  2021  |  LAB ON A CHIP

Cellular mechanical properties (e.g. compressibility) are important biophysical markers in relation to cellular processes and func..

Annexin A1 Is Required for Efficient Tumor Initiation and Cancer Stem Cell Maintenance in a Model of Human Breast Cancer

Cameron N Johnstone, Yan Tu, Shenna Langenbach, David Baloyan, Andrew D Pattison, Peter Lock, Kara L Britt, Brian D Lehmann, Traude H Beilharz, Matthias Ernst, Robin L Anderson, Alastair G Stewart

Journal article  |  2021  |  CANCERS

Triple-negative breast cancer (TNBC) has a poor outcome compared to other breast cancer subtypes, and new therapies that target th..

Translational Pharmacology and Clinical Trials

Meina Li, Alastair G Stewart

Book Chapter  |  2021

Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments

Cheng Peng, Alastair G Stewart, Owen L Woodman, Rebecca H Ritchie, Cheng Xue Qin

Journal article  |  2020  |  FRONTIERS IN PHARMACOLOGY

Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease (NAFLD). Currently, around 25% of the populat..

Cellular Microenvironment Stiffness Regulates Eicosanoid Production and Signaling Pathways

Asres Berhan, Trudi Harris, Jade Jaffar, Fernando Jativa, Shenna Langenbach, Ingrid Loennstedt, Monther Alhamdoosh, Milica Ng, Peter Lee, Glen Westall, Nick Wilson, Michael Wilson, Alastair G Stewart

Journal article  |  2020  |  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pathological changes in the biomechanical environment are implicated in the progression of idiopathic pulmonary fibrosis (IPF). St..

Pharmacological Restoration of mOod in HEART Failure: outcomes of the PRO-HEART trial

DL Hare, D Toia, AG Stewart, S Toukhsati

Conference Proceedings  |  2020  |  EUROPEAN HEART JOURNAL

Abstract Background Depression is common in chronic heart failure (CHF) patien..

An Automated Quantitative Method to Analyze Immunohistochemistry and Immunocytochemistry Images

Yongcheng Jin, Kexin Shi, Xumei Gao, Shenna Y Langenbach, Meina Li, Trudi Harris, Alastair G Stewart

Journal article  |  2020  |  Journal of Engineering and Science in Medical Diagnostics and Therapy

AbstractImmunohistochemistry (IHC) plays an important role in target protein analysis. However, many researchers analyze IHC image..

Regulation of Airway Smooth Muscle Proliferation by β2-Adrenoceptor Agonists

Alastair G Stewart, Paul R Tomlinson, Leslie Schachte

Book Chapter  |  2020

On-chip surface acoustic wave and micropipette aspiration techniques to assess cell elastic properties.

Yanqi Wu, Tianhong Cheng, Qianyu Chen, Bryan Gao, Alastair G Stewart, Peter VS Lee

Journal article  |  2020  |  Biomicrofluidics

The cytoskeletal mechanics and cell mechanical properties play an important role in cellular behaviors. In this study, in order to..