Alastair Stewart

The FDA modernisation act 2.0: Bringing non-animal technologies to the regulatory table.

Alastair Stewart, Delphine Denoyer, Xumei Gao, Yi-Chin Toh

Journal article  |  2023  |  Drug Discov Today

The FDA modernisation Act 2.0 marks a game-changing legislation enabling drug registration without the absolute requirement for th..

Thunderstorm asthma in seasonal allergic rhinitis: The TAISAR study

Jo A Douglass, Caroline Lodge, Samantha Chan, Alice Doherty, Ju Ann Tan, Celina Jin, Alastair Stewart, Anne M Southcott, Andrew Gillman, Joy Lee, Danny Csutoros, Liam Hannan, Laurence Ruane, Sara Barnes, Lou Irving, Nur-Shirin Harun, Phillipe Lachapelle, Kymble Spriggs, Michael Sutherland, Katharine See, et al.

Journal article  |  2022  |  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

BACKGROUND: Asthma epidemics associated with thunderstorms have had catastrophic effects on individuals and emergency services. Se..

ACE2 Expression in Organotypic Human Airway Epithelial Cultures and Airway Biopsies

Qianyu Chen, Shenna Langenbach, Meina Li, Yuxiu C Xia, Xumei Gao, Matthew J Gartner, Elizabeth A Pharo, Sinead M Williams, Shawn Todd, Nadeene Clarke, Sarath Ranganathan, Michelle L Baker, Kanta Subbarao, Alastair G Stewart

Journal article  |  2022  |  FRONTIERS IN PHARMACOLOGY

Coronavirus disease 2019 (COVID-19) caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a..

Comprehensive multiplexed superfusion system enables physiological emulation in cell culture: exemplification by persistent circadian entrainment

Xumei Gao, Yanqi Wu, Tianhong Cheng, Alastair G Stewart

Journal article  |  2022  |  LAB ON A CHIP

Cells and tissues are routinely cultured in vitro for biological research with findings being extrapolated to their host organ and..

Editorial: Accelerated Translation Using Microphysiological Organoid and Microfluidic Chip Models

Kambez H Benam, Janette K Burgess, Alastair G Stewart

Journal article  |  2022  |  FRONTIERS IN PHARMACOLOGY

Translational Pharmacology and Clinical Trials

Meina Li, Alastair G Stewart

Book Chapter  |  2022

High-throughput microfluidic compressibility cytometry using multi-tilted-angle surface acoustic wave

Yanqi Wu, Alastair G Stewart, Peter VS Lee

Journal article  |  2021  |  LAB ON A CHIP

Cellular mechanical properties (e.g. compressibility) are important biophysical markers in relation to cellular processes and func..

Annexin A1 Is Required for Efficient Tumor Initiation and Cancer Stem Cell Maintenance in a Model of Human Breast Cancer

Cameron N Johnstone, Yan Tu, Shenna Langenbach, David Baloyan, Andrew D Pattison, Peter Lock, Kara L Britt, Brian D Lehmann, Traude H Beilharz, Matthias Ernst, Robin L Anderson, Alastair G Stewart

Journal article  |  2021  |  CANCERS

Triple-negative breast cancer (TNBC) has a poor outcome compared to other breast cancer subtypes, and new therapies that target th..

Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies

Suowen Xu, Iqra Ilyas, Peter J Little, Hong Li, Danielle Kamato, Xueying Zheng, Sihui Luo, Zhuoming Li, Peiqing Liu, Jihong Han, Ian C Harding, Eno E Ebong, Scott J Cameron, Alastair G Stewart, Jianping Weng

Journal article  |  2021  |  PHARMACOLOGICAL REVIEWS

The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in maintaining multiorgan health and hom..

Managing Exacerbations in Thunderstorm Asthma: Current Insights

Josh Chatelier, Samantha Chan, Ju Ann Tan, Alastair G Stewart, Jo Anne Douglass

Journal article  |  2021  |  JOURNAL OF INFLAMMATION RESEARCH

Epidemic thunderstorm asthma (ETSA) occurs following a thunderstorm due to the interaction of environmental and immunologic factor..