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Alastair Stewart's selected work
Casein Kinase 1 Delta Inhibitors Reset The Clock To Suppress Inflammation And Fibrosis
Rhythm on a chip: circadian entrainment in vitro is the next frontier in body-on-a chip te..
Study To Understand Immunoglobulin Levels, Leucocytes Content And Various Biomarkers In Th..
Displaying the 39 most recent projects by Alastair Stewart.
Biosecurity Enhancement Through Pathophysiologically Appropriate Models Of Epithelial Infection: Enabling Anti-Viral And Immunisation Therapeutic And Preventative Developments (Project 1.4 Under ARC Cptt)
The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the ..
Internal Research Grant
Displaying the 236 most recent scholarly works by Alastair Stewart.
A concise review on cancer treatment methods and delivery systems
E Bidram, Y Esmaeili, H Ranji-Burachaloo, N Al-Zaubai, A Zarrabi, A Stewart, DE Dunstan
Journal article | 2019 | Journal of Drug Delivery Science and Technology
The ultimate purpose of current cancer research is to develop a comprehensive treatment for cancer. Recent studies have shown an i..
Rhythm on a chip: circadian entrainment in vitro is the next frontier in body-on-a chip technology
Jean-Michel Fustin, Meina Li, Bryan Gao, Qianyu Chen, Tianhong Cheng, Alastair G Stewart
Journal article | 2019 | Current Opinion in Pharmacology
Organoids, bioprinted mini-tissues and body-on-a-chip technologies are poised to transform the practice of preclinical pharmacolog..
A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-beta 1 in Steroid-Resistant Airway Diseases
Meina Li, Christine R Keenan, Guillermo Lopez-Campos, Jonathan E Mangum, Qianyu Chen, Danica Prodanovic, Yuxiu C Xia, Shenna Y Langenbach, Trudi Harris, Vinzenz Hofferek, Gavin E Reid, Alastair G Stewart
Journal article | 2019 | iScience
Casein Kinase 1 delta/epsilon Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-beta in Pulmonary Fibrosis
Christine R Keenan, Shenna Y Langenbach, Fernando Jativa, Trudi Harris, Meina Li, Qianyu Chen, Yuxiu Xia, Bryan Gao, Michael J Schuliga, Jade Jaffar, Danica Prodanovic, Yan Tu, Asres Berhan, Peter VS Lee, Glen P Westall, Alastair G Stewart
Journal article | 2018 | Frontiers in Pharmacology
Functional and genomic characterisation of a xenograft model system for the study of metastasis in triple-negative breast cancer
Cameron N Johnstone, Andrew D Pattison, Kylie L Gorringe, Paul F Harrison, David R Powell, Peter Lock, David Baloyan, Matthias Ernst, Alastair G Stewart, Traude H Beilharz, Robin L Anderson
Journal article | 2018 | Disease Models & Mechanisms
Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity
Michael Schuliga, Jade Jaffar, Asres Berhan, Shenna Langenbach, Trudi Harris, David Waters, Peter VS Lee, Christopher Grainge, Glen Westall, Darryl Knight, Alastair G Stewart
Journal article | 2017 | American Journal of Physiology-Lung Cellular and Molecular Physiology
Glucocorticoid resistance of migration and gene expression in a daughter MDA-MB-231 breast tumour cell line selected for high metastatic potential
Ebony R Fietz, Christine R Keenan, Guillermo Lopez-Campos, Yan Tu, Cameron N Johnstone, Trudi Harris, Alastair G Stewart
Journal article | 2017 | Scientific Reports
Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice
Cheng Xue Qin, Lauren T May, Renming Li, Nga Cao, Sarah Rosli, Deo Minh, Amy E Alexander, Duncan Horlock, Jane E Bourke, Yuan H Yang, Alastair G Stewart, David M Kaye, Xiao-Jun Du, Patrick M Sexton, Arthur Christopoulos, Xiao-Ming Gao, Rebecca H Ritchie
Journal article | 2017 | Nature Communications
An Official American Thoracic Society Research Statement: Current Challenges Facing Research and Therapeutic Advances in Airway Remodeling
YS Prakash, Andrew J Halayko, Reinoud Gosens, Reynold A Panettieri, Blanca Camoretti-Mercado, Raymond B Penn
Journal article | 2017 | American Journal of Respiratory and Critical Care Medicine
Glucocorticoid Insensitivity in Virally Infected Airway Epithelial Cells Is Dependent on Transforming Growth Factor-beta Activity
Yuxiu C Xia, Asmaa Radwan, Christine R Keenan, Shenna Y Langenbach, Meina Li, Danica Radojicic, Sarah L Londrigan, Rosa C Gualano, Alastair G Stewart
Journal article | 2017 | PLOS Pathogens
CD151, a laminin receptor showing increased expression in asthmatic patients, contributes to airway hyperresponsiveness through calcium signaling
Yongkang Qiao, John Kit Chung Tam, Sheryl SL Tan, Yee Kit Tai, Chin Yein Chin, Alastair G Stewart, Leonie Ashman, Kiyotoshi Sekiguchi, Shenna Y Langenbach, Gerald Stelmack, Andrew J Halayko, Thai Tran
Journal article | 2017 | Journal of Allergy and Clinical Immunology
Neonatal pneumococcal colonisation caused by Influenza A infection alters lung function in adult mice
Meaghan FitzPatrick, Simon G Royce, Shenna Langenbach, Jonathan McQualter, Patrick C Reading, Odilia Wijburg, Gary P Anderson, Alastair Stewart, Jane Bourke, Steven Bozinovski
Journal article | 2016 | Scientific Reports
The Coagulant Factor Xa Induces Protease-Activated Receptor-1 and Annexin A2-Dependent Airway Smooth Muscle Cytokine Production and Cell Proliferation
Michael Schuliga, Simon G Royce, Shenna Langenbach, Asres Berhan, Trudi Harris, Christine R Keenan, Alastair G Stewart
Journal article | 2016 | American Journal of Respiratory Cell and Molecular Biology
The Antimalarial Drug Artesunate Inhibits Primary Human Cultured Airway Smooth Muscle Cell Proliferation
Sheryl SL Tan, Benjamin Ong, Chang Cheng, Wanxing Eugene Ho, John KC Tam, Alastair G Stewart, Trudi Harris, WS Fred Wong, Tran Thai
Journal article | 2014 | American Journal of Respiratory Cell and Molecular Biology
Plasminogen-Stimulated Inflammatory Cytokine Production by Airway Smooth Muscle Cells Is Regulated by Annexin A2
Michael Schuliga, Shenna Langenbach, Yuxiu C Xia, Chengxue Qin, Josephine SL Mok, Trudi Harris, Graham A Mackay, Robert L Medcalf, Alastair G Stewart
Journal article | 2013 | American Journal of Respiratory Cell and Molecular Biology
Laminin drives survival signals to promote a contractile smooth muscle phenotype and airway hyperreactivity
Tran Thai, Chun Ming Teoh, John Kit Chung Tam, Yongkang Qiao, Chin Yein Chin, Oi Khuan Chong, Alastair G Stewart, Trudi Harris, Wai Shiu Fred Wong, Shou Ping Guan, Bernard P Leung, William T Gerthoffer, Helmut Unruh, Andrew J Halayko
Journal article | 2013 | FASEB Journal
Transforming Growth Factor-beta-Induced Differentiation of Airway Smooth Muscle Cells Is Inhibited by Fibroblast Growth Factor-2
Michael Schuliga, Aqeel Javeed, Trudi Harris, Yuxiu Xia, Chengxue Qin, Zhexing Wang, Xuehua Zhang, Peter VS Lee, Bianca Camoretti-Mercado, Alastair G Stewart
Journal article | 2013 | American Journal of Respiratory Cell and Molecular Biology
Laminin Drives Survival Signals To Promote A Contractile Smooth Muscle Phenotype And Airway Hyperreactivity
T Tran, C Teoh, J Tam, Y Qiao, C Chin, O Chong, AG Stewart, T Harris, W Wong, S Guan, B Leung, WT Gerthoffer, H Unruh, AJ Halayko
Conference Proceedings | 2013 | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: Vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition
Andrew J Tilley, Shannon D Zanatta, Cheng Xue Qin, In-Kyeom Kim, Young-Mi Seok, Alastair Stewart, Owen L Woodman, Spencer J Williams
Journal article | 2012 | Bioorganic & Medicinal Chemistry
Functional Expression of IgG-Fc Receptors in Human Airway Smooth Muscle Cells
YuXiu C Xia, Michael Schuliga, Malcolm Shepherd, Maree Powell, Trudi Harris, Shenna Y Langenbach, Peck Szee Tan, William T Gerthoffer, P Mark Hogarth, Alastair G Stewart, Graham A Mackay
Journal article | 2011 | American Journal of Respiratory Cell and Molecular Biology
K(Ca)3.1 Ca2 -Activated K channels regulate human airway smooth muscle proliferation
Malcolm C Shepherd, S Mark Duffy, Trudi Harris, Glenn Cruse, Michael Schuliga, Chris E Brightling, Craig B Neylon, Peter Bradding, Alastair G Stewart
Journal article | 2007 | American Journal of Respiratory Cell and Molecular Biology
Resistance of fibrogenic responses to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice
Shenna Y Langenbach, Ben J Wheaton, Darren J Fernandes, Catherine Jones, Tara E Sutherland, Bronwyn C Wraith, Trudi Harris, Michael J Schuliga, Catriona McLean, Alastair G Stewart
Journal article | 2007 | Canadian Journal of Physiology and Pharmacology
Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma
SS An, TR Bai, JHT Bates, JL Black, RH Brown, V Brusasco, P Chitano, L Deng, M Dowell, DH Eidelman, B Fabry, NJ Fairbank, LE Ford, JJ Fredberg, WT Gerthoffer, SH Gilbert, R Gosens, SJ Gunst, AJ Halayko, RH Ingram, et al.
Journal article | 2007 | European Respiratory Journal
On the terminology for describing the length-force relationship and its changes in airway smooth muscle
TR Bai, JHT Bates, V Brusasco, B Camoretti-Mercado, P Chitano, LH Deng, M Dowell, B Fabry, LE Ford, JJ Fredberg, WT Gerthoffer, SH Gilbert, SJ Gunst, CM Hai, AJ Halayko, SJ Hirst, AL James, LJ Janssen, KA Jones, GG King, et al.
Journal article | 2004 | Journal of Applied Physiology
Proliferative aspects of airway smooth muscle.
Stuart J Hirst, James G Martin, John V Bonacci, Vivien Chan, Elizabeth D Fixman, Qutayba A Hamid, Berenice Herszberg, Jean-Pierre Lavoie, Clare G McVicker, Lyn M Moir, Trang T-B Nguyen, Qi Peng, David Ramos-Barbón, Alastair G Stewart
Journal article | 2004 | Journal of Allergy and Clinical Immunology
Increased airway smooth muscle (ASM) mass is perhaps the most important component of the airway wall remodeling process in asthma...
Early inducible nitric oxide synthase 2 (NOS 2) activity enhances ischaemic skin flap survival.
Sunao Furuta, Peter Vadiveloo, Rosalind Romeo-Meeuw, Wayne Morrison, Alastair Stewart, Geraldine Mitchell
Journal article | 2004 | Angiogenesis
A functional skin-flap model of angiogenesis in the mouse was utilized to investigate ischaemic flap survival/angiogenesis whilst ..
Airway Hyperresponsiveness: From Molecules to Bedside Invited Review: Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma?
DJ FERNANDES, RW MITCHELL, O LAKSER, M DOWELL, A STEWART, J SOLWAY
Journal article | 2003 | Journal of Applied Physiology
2-methoxyestradiol and analogs as novel antiproliferative agents: Analysis of three-dimensional quantitative structure-activity relationships for DNA synthesis inhibition and estrogen receptor binding
RA Hughes, T Harris, E Altmann, D McAllister, R Vlahos, A Robertson, M Cushman, ZQ Wang, AG Stewart
Journal article | 2002 | Molecular Pharmacology
beta 2-adrenergic receptor agonists and cAMP arrest human cultured airway smooth muscle cells in the G(1) phase of the cell cycle: Role of proteasome degradation of cyclin D1
AG Stewart, T Harris, DJ Fernandes, LC Schachte, V Koutsoubos, E Guida, CE Ravenhall, P Vadiveloo, JW Wilson
Journal article | 1999 | Molecular Pharmacology
Glucocorticoids inhibit proliferation, cyclin D1 expression, and retinoblastoma protein phosphorylation, but not activity of the extracellular-regulated kinases in human cultured airway smooth muscle
D Fernandes, E Guida, V Koutsoubos, T Harris, P Vadiveloo, JW Wilson, AG Stewart
Journal article | 1999 | American Journal of Respiratory Cell and Molecular Biology
Timing of administration of dexamethasone or the nitric oxide synthase inhibitor, nitro-L-arginine methyl ester, is critical for effective treatment of ischaemia-reperfusion injury to rat skeletal muscle
BM Zhang, KR Knight, B Dowsing, E Guida, LH Phan, MJ Hickey, WA Morrison, AG Stewart
Journal article | 1997 | Clinical Science
Platelet-activating factor (PAF) receptor antagonism by WEB 2170 improves the survival of ischaemic skeletal muscle.
DA Lepore, KR Knight, AG Stewart, M Riccio, WA Morrison
Journal article | 1995 | Annals of the Academy of Medicine Singapore
The platelet-activating factor (PAF) receptor antagonist, WEB 2170, significantly improved the survival of ischaemic rabbit skelet..
Tumour necrosis factor alpha augments the release of an endothelium-dependent vasoconstrictor from human polymorphonuclear leukocytes.
CG Sobey, GJ Dusting, AG Stewart
Journal article | 1992 | Journal of Cardiovascular Pharmacology
We have studied the effect of cytokine priming by recombinant human tumour necrosis factor alpha (rhTNF alpha) on the release of v..
ACETYLCHOLINE AND HISTAMINE INTERACT SUPRA-ADDITIVELY ON BRONCHOMOTOR TONE IN GUINEA-PIGS INVIVO - A POSSIBLE CONSEQUENCE OF THE RELATIONSHIP BETWEEN AIRWAYS RESISTANCE AND CALIBER
AG STEWART, DC THOMPSON, MR FENNESSY
Journal article | 1985 | Archives Internationales de Pharmacodynamie et de Therapie
Displaying the 3 most recent news articles by Alastair Stewart.
Honours, Awards and Fellowships
ASCEPT visiting lecturer to the British Pharmacological Society 2009.
FBPHS - Fellow of the British Pharmacological Society
Pharmacology And Therapeutics
Thoracic Society of Australia and New Zealand
American Thoracic Society
Australian Society for Medical Research
British Pharmacological Society
Australian Society of Clinical and Experimental Pharmacologists and Toxicologists
Doctor of Philosophy
University of Melbourne
Bachelor of Science
University of Melbourne