Lea Delbridge

Systematic quantification of histologic ventricular fibrosis in isolated mitral valve prolapse and sudden cardiac death.

Hui-Chen Han, Sarah A Parsons, Claire L Curl, Andrew W Teh, Antonia JA Raaijmakers, Anoop N Koshy, Trishe Leong, Louise M Burrell, David O'Donnell, Jitendra K Vohra, Jonathan M Kalman, Prashanthan Sanders, David L Hare, Omar Farouque, Lea Delbridge, Han S Lim

Journal article  |  2020  |  Heart Rhythm

BACKGROUND: Cardiac fibrosis in mitral valve prolapse (MVP) is implicated in the development of sudden cardiac death (SCD); howeve..

Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality

Chrishan J Nalliah, James R Bell, Antonia JA Raaijmakers, Helen M Waddell, Simon P Wells, Gabriel B Bernasochi, Magdalene K Montgomery, Simon Binny, Troy Watts, Subodh B Joshi, Elaine Lui, Choon Boon Sim, Marco Larobina, Michael O'Keefe, John Goldblatt, Alistair Royse, Geoffrey Lee, Enzo R Porrello, Matthew J Watt, Peter M Kistler, et al.

Journal article  |  2020  |  Journal of the American College of Cardiology

BACKGROUND: Clinical studies have reported that epicardial adipose tissue (EpAT) accumulation associates with the progression of a..

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology

Ayeshah A Rosdah, William J Smiles, Jonathan S Oakhill, John W Scott, Christopher G Langendorf, Lea MD Delbridge, Jessica K Holien, Shiang Y Lim

Journal article  |  2020  |  Pharmacology & Therapeutics

Mitochondria are dynamic organelles constantly undergoing fusion and fission. A concerted balance between the process of mitochond..

A novel mass spectrometric methodology facilitates quantification of testosterone and progesterone, but not estrogens in cardiac and adipose tissues

Gabriel B Bernasochi, Thusitha TW Rupasinghe, James R Bell, Ute Roessner, Wah Chin Boon, Lea MD Delbridge

Conference Proceedings  |  2020  |  Journal of Molecular and Cellular Cardiology

214 Epicardial Adipose Tissue Prolongs Field Potential Duration in Cultured Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

S Wells, H Waddell, C Curl, L Delbridge, J Bell

Journal article  |  2020  |  Heart Lung and Circulation

Cardiomyocyte functional screening: interrogating comparative electrophysiology of high-throughput model cell systems

Simon P Wells, Helen M Waddell, Choon Boon Sim, Shiang Y Lim, Gabriel B Bernasochi, Davor Pavlovic, Paulus Kirchhof, Enzo R Porrello, Lea MD Delbridge, James R Bell

Journal article  |  2019  |  American Journal of Physiology - Cell Physiology

Cardiac arrhythmias of both atrial and ventricular origin are an important feature of cardiovascular disease. Novel anti-arrhythmi..

HFpEF-Time to Explore the Role of Genetic Heterogeneity in Phenotypic Variability New Mechanistic Insights Offer Promise for Personalized Therapies

Enzo R Porrello, Lea MD Delbridge

Journal article  |  2019  |  Circulation

Myocardial Energy Stress, Autophagy Induction, and Cardiomyocyte Functional Responses

Lorna J Daniels, Upasna Varma, Marco Annandale, Eleia Chan, Kimberley M Mellor, Lea MD Delbridge

Journal article  |  2019  |  Antioxidants & Redox Signaling

Impact of Estrogens on the Regulation of White, Beige, and Brown Adipose Tissue Depots

Gabriel B Bernasochi, James R Bell, Evan R Simpson, Lea MD Delbridge, Wah Chin Boon

Journal article  |  2019  |  Comprehensive Physiology

As adipose tissue depots are active endocrine organs, they secrete a variety of hormones (including estrogens from white adipose) ..

Cardiomyocyte transcription is controlled by combined MR and circadian clock signalling.

ELizabeth K Fletcher, Monica Kanki, James Morgan, David W Ray, Lea Delbridge, Peter James Fuller, Colin D Clyne, Morag J Young

Journal article  |  2019  |  Journal of Endocrinology

We previously identified a critical pathogenic role for MR activation in cardiomyocytes that included a potential interaction betw..