Lea Delbridge

Fructose Metabolism and Cardiac Metabolic Stress

M Annandale, LJ Daniels, X Li, JPH Neale, AHL Chau, HA Ambalawanar, SL James, P Koutsifeli, LMD Delbridge, KM Mellor

Journal article  |  2021  |  FRONTIERS IN PHARMACOLOGY

Cardiovascular disease is one of the leading causes of mortality in diabetes. High fructose consumption has been linked with the d..

Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor

Choon Boon Sim, Belinda Phipson, Mark Ziemann, Haloom Rafehi, Richard J Mills, Kevin I Watt, Kwaku D Abu-Bonsrah, Ravi KR Kalathur, Holly K Voges, Doan T Dinh, Menno ter Huurne, Celine J Vivien, Antony Kaspi, Harikrishnan Kaipananickal, Alejandro Hidalgo, Leanne MD Delbridge, Rebecca L Robker, Paul Gregorevic, Cristobal G dos Remedios, Sean Lal, et al.

Journal article  |  2021  |  CIRCULATION

BACKGROUND: Despite in-depth knowledge of the molecular mechanisms controlling embryonic heart development, little is known about ..

Systematic quantification of histologic ventricular fibrosis in isolated mitral valve prolapse and sudden cardiac death

Hui-Chen Han, Sarah A Parsons, Claire L Curl, Andrew W Teh, Antonia JA Raaijmakers, Anoop N Koshy, Trishe Leong, Louise M Burrell, David O'Donnell, Jitendra K Vohra, Jonathan M Kalman, Prashanthan Sanders, David L Hare, Omar Farouque, Lea MD Delbridge, Han S Lim

Journal article  |  2021  |  HEART RHYTHM

BACKGROUND: Cardiac fibrosis in mitral valve prolapse (MVP) is implicated in the development of sudden cardiac death (SCD); howeve..

Novel Mitochondrial Drp1 Inhibitors for Cardioprotection

A Rosdah, W Smiles, J Lees, J Oakhill, C Langendorf, L Delbridge, J Holien, S Lim

Journal article  |  2021  |  Heart, Lung and Circulation

Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality

Chrishan J Nalliah, James R Bell, Antonia JA Raaijmakers, Helen M Waddell, Simon P Wells, Gabriel B Bernasochi, Magdalene K Montgomery, Simon Binny, Troy Watts, Subodh B Joshi, Elaine Lui, Choon Boon Sim, Marco Larobina, Michael O'Keefe, John Goldblatt, Alistair Royse, Geoffrey Lee, Enzo R Porrello, Matthew J Watt, Peter M Kistler, et al.

Journal article  |  2020  |  JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

BACKGROUND: Clinical studies have reported that epicardial adipose tissue (EpAT) accumulation associates with the progression of a..

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology

Ayeshah A Rosdah, William J Smiles, Jonathan S Oakhill, John W Scott, Christopher G Langendorf, Lea MD Delbridge, Jessica K Holien, Shiang Y Lim

Journal article  |  2020  |  PHARMACOLOGY & THERAPEUTICS

Mitochondria are dynamic organelles constantly undergoing fusion and fission. A concerted balance between the process of mitochond..

A novel mass spectrometric methodology facilitates quantification of testosterone and progesterone, but not estrogens in cardiac and adipose tissues

Gabriel B Bernasochi, Thusitha TW Rupasinghe, James R Bell, Ute Roessner, Wah Chin Boon, Lea MD Delbridge

Conference Proceedings  |  2020  |  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

214 Epicardial Adipose Tissue Prolongs Field Potential Duration in Cultured Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

S Wells, H Waddell, C Curl, L Delbridge, J Bell

Journal article  |  2020  |  Heart, Lung and Circulation

Cardiomyocyte functional screening: interrogating comparative electrophysiology of high-throughput model cell systems

Simon P Wells, Helen M Waddell, Choon Boon Sim, Shiang Y Lim, Gabriel B Bernasochi, Davor Pavlovic, Paulus Kirchhof, Enzo R Porrello, Lea MD Delbridge, James R Bell

Journal article  |  2019  |  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cardiac arrhythmias of both atrial and ventricular origin are an important feature of cardiovascular disease. Novel antiarrhythmic..

HFpEF-Time to Explore the Role of Genetic Heterogeneity in Phenotypic Variability New Mechanistic Insights Offer Promise for Personalized Therapies

Enzo R Porrello, Lea MD Delbridge

Journal article  |  2019  |  CIRCULATION