Lea Delbridge

Cardiomyocyte functional screening: interrogating comparative electrophysiology of high-throughput model cell systems

Simon P Wells, Helen M Waddell, Choon Boon Sim, Shiang Y Lim, Gabriel B Bernasochi, Davor Pavlovic, Paulus Kirchhof, Enzo R Porrello, Lea MD Delbridge, James R Bell

Journal article  |  2019  |  American Journal of Physiology-Cell Physiology

Cardiac arrhythmias of both atrial and ventricular origin are an important feature of cardiovascular disease. Novel anti-arrhythmi..

HFpEF-Time to Explore the Role of Genetic Heterogeneity in Phenotypic Variability New Mechanistic Insights Offer Promise for Personalized Therapies

Enzo R Porrello, Lea MD Delbridge

Journal article  |  2019  |  Circulation

Myocardial Energy Stress, Autophagy Induction, and Cardiomyocyte Functional Responses

Lorna J Daniels, Upasna Varma, Marco Annandale, Eleia Chan, Kimberley M Mellor, Lea MD Delbridge

Journal article  |  2019  |  Antioxidants & Redox Signaling

Impact of Estrogens on the Regulation of White, Beige, and Brown Adipose Tissue Depots

Gabriel B Bernasochi, James R Bell, Evan R Simpson, Lea MD Delbridge, Wah Chin Boon

Journal article  |  2019  |  Comprehensive Physiology

As adipose tissue depots are active endocrine organs, they secrete a variety of hormones (including estrogens from white adipose) ..

Cardiomyocyte transcription is controlled by combined MR and circadian clock signalling.

ELizabeth K Fletcher, Monica Kanki, James Morgan, David W Ray, Lea Delbridge, Peter James Fuller, Colin D Clyne, Morag J Young

Journal article  |  2019  |  Journal of Endocrinology

We previously identified a critical pathogenic role for MR activation in cardiomyocytes that included a potential interaction betw..

Mitochondrial Assays Using Cardiac Stem Cells.

Ayeshah A Rosdah, Lea MD Delbridge, Shiang Y Lim

Book Chapter  |  2019  |  Methods in Molecular Biology

Ischemic heart disease is the leading cause of death worldwide. Stem cell therapy to repair and regenerate the infarcted myocardiu..

Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture

Shouryadipta Ghosh, Kenneth Tran, Lea MD Delbridge, Anthony JR Hickey, Eric Hanssen, Edmund J Crampin, Vijay Rajagopal

Journal article  |  2018  |  PLOS COMPUTATIONAL BIOLOGY

The myocardium and sex steroid hormone influences

Gabriel B Bernasochi, Wah Chin Boon, Lea Md Delbridge, James R Bell

Journal article  |  2018  |  Current Opinion in Physiology

Cardiac troponins may be irreversibly modified by glycation: novel potential mechanisms of cardiac performance modulation

Johannes V Janssens, Brendan Ma, Margaret A Brimble, Jennifer E Van Eyk, Lea MD Delbridge, Kimberley M Mellor

Journal article  |  2018  |  Scientific Reports

Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy

PR Prestes, FZ Marques, G Lopez-Campos, P Lewandowski, LMD Delbridge, FJ Charchar, SB Harrap

Journal article  |  2018  |  Physiological Genomics

Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive-A New Preclinical Model

Claire L Curl, Vennetia R Danes, James R Bell, Antonia JA Raaijmakers, Wendy TK Ip, Chanchal Chandramouli, Tristan W Harding, Enzo R Porrello, Jeffrey R Erickson, Fadi J Charchar, Andrew R Kompa, Amanda J Edgley, David J Crossman, Christian Soeller, Kimberley M Mellor, Jonathan M Kalman, StephenB Harrap, Lea MD Delbridge

Journal article  |  2018  |  Journal of the American Heart Association

Molecular mechanisms of cardiac pathology in diabetes - Experimental insights

U Varma, P Koutsifeli, VL Benson, KM Mellor, LMD Delbridge

Journal article  |  2018  |  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

David J Anderson, David I Kaplan, Katrina M Bell, Katerina Koutsis, John M Haynes, Richard J Mills, Dean G Phelan, Elizabeth L Qian, Ana Rita Leitoguinho, Deevina Arasaratnam, Tanya Labonne, Elizabeth S Ng, Richard P Davis, Simona Casini, Robert Passier, James E Hudson, Enzo R Porrello, Mauro W Costa, Arash Rafii, Clare L Curl, et al.

Journal article  |  2018  |  Nature Communications

Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia

Chanchal Chandramouli, Melissa E Reichelt, Claire L Curl, Upasna Varma, Laura A Bienvenu, Parisa Koutsifeli, Antonia JA Raaijmakers, Miles J De Blasio, Cheng Xue Qin, Alicia J Jenkins, Rebecca H Ritchie, Kimberley M Mellor, Lea MD Delbridge

Journal article  |  2018  |  Scientific Reports

Mdivi-1 Protects Human W8B2( ) Cardiac Stem Cells from Oxidative Stress and Simulated Ischemia-Reperfusion Injury

Ayeshah A Rosdah, Simon T Bond, Priyadharshini Sivakumaran, Ashfaqul Hoque, Jonathan S Oakhill, Brian G Drew, Lea MD Delbridge, Shiang Y Lim

Journal article  |  2017  |  Stem Cells and Development

Chronic in vivo nitric oxide deficiency impairs cardiac functional recovery after ischemia in female (but not male) mice.

Laura A Bienvenu, James Morgan, Melissa E Reichelt, Lea MD Delbridge, Morag J Young

Journal article  |  2017  |  Journal of Molecular and Cellular Cardiology

Nitric oxide (NO) is an important regulator of cardiac function and plays a key role in ischemic cardioprotection. The role of chr..

High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice

Sarah E Heywood, Adele L Richart, Darren C Henstridge, Karen Alt, Helen Kiriazis, Claire Zammit, Andrew L Carey, Helene L Kammoun, Lea M Delbridge, Medini Reddy, Yi-Ching Chen, Xiao-Jun Du, Christoph E Hagemeyer, Mark A Febbraio, Andrew L Siebel, Bronwyn A Kingwell

Journal article  |  2017  |  Science Translational Medicine

Pericardial adipose and aromatase: A new translational target for aging, obesity and arrhythmogenesis?

Gabriel B Bernasochi, Wah Chin Boon, Claire L Curl, Upasna Varma, Salvatore Pepe, Marianne Tare, Laura J Parry, Evdokia Dimitriadis, Stephen B Harrap, Chrishan J Nalliah, Jonathan M Kalman, Lea MD Delbridge, James R Bell

Journal article  |  2017  |  Journal of Molecular and Cellular Cardiology

Deoxycorticosterone/Salt-Mediated Cardiac Inflammation and Fibrosis Are Dependent on Functional CLOCK Signaling in Male Mice.

Elizabeth K Fletcher, James Morgan, David R Kennaway, Laura A Bienvenu, Amanda J Rickard, Lea MD Delbridge, Peter J Fuller, Colin D Clyne, Morag J Young

Journal article  |  2017  |  Endocrinology

Activation of the mineralocorticoid receptor (MR) promotes inflammation, fibrosis, and hypertension. Clinical and experimental stu..

A Small Cohort Omega-3 PUFA Supplement Study: Implications of Stratifying According to Lipid Membrane Incorporation in Cardiac Surgical Patients

TK Wendy, Chanchal Chandramouli, Julian A Smith, Peter L McLennan, Salvatore Pepe, Lea MD Delbridge

Journal article  |  2017  |  Heart, Lung and Circulation

Myocardial stress and autophagy: mechanisms and potential therapies

Lea MD Delbridge, Kimberley M Mellor, David J Taylor, Roberta A Gottlieb

Journal article  |  2017  |  Nature Reviews Cardiology

Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

Francine Z Marques, Priscilla R Prestes, Sean G Byars, Scott C Ritchie, Peter Wurtz, Sheila K Patel, Scott A Booth, Indrajeetsinh Rana, Yosuke Minoda, Stuart P Berzins, Claire L Curl, James R Bell, Bryan Wai, Piyush M Srivastava, Antti J Kangas, Pasi Soininen, Saku Ruohonen, Mika Kahonen, Terho Lehtimaki, Emma Raitoharju, et al.

Journal article  |  2017  |  JOURNAL OF THE AMERICAN HEART ASSOCIATION

Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency

Duncan E Crombie, Claire L Curl, Antonia JA Raaijmakers, Priyadharshini Sivakumaran, Tejal Kulkarni, Raymond CB Wong, Itsunari Minami, Marguerite V Evans-Galea, Shiang Y Lim, Lea Delbridge, Louise A Corben, Mirella Dottori, Norio Nakatsuji, Ian A Trounce, Alex W Hewitt, Martin B Delatycki, Martin F Pera, Alice Pebay

Journal article  |  2017  |  AGING-US

Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium

Kevin J Ashton, Melissa E Reichelt, S Jamal Mustafa, Bunyen Teng, Catherine Ledent, Lea MD Delbridge, Polly A Hofmann, R Ray Morrison, John P Headrick

Journal article  |  2017  |  Purinergic Signalling

Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications

Cheng Xue Qin, Rochelle Sleaby, Amy J Davidoff, James R Bell, Miles J De Blasio, Leanne M Delbridge, John C Chatham, Rebecca H Ritchie

Journal article  |  2017  |  Pharmacological Research

Changes in mitochondrial morphology and organization can enhance energy supply from mitochondrial oxidative phosphorylation in diabetic cardiomyopathy

Jan Jarosz, Shouryadipta Ghosh, Lea MD Delbridge, Amorita Petzer, Anthony JR Hickey, Edmund J Crampin, Eric Hanssen, Vijay Rajagopal

Journal article  |  2017  |  American Journal of Physiology-Cell Physiology

Angiotensin-(1-9) New Promise for Post-Infarct Functional Therapy

Lea MD Delbridge, Laura A Bienvenu, Kimberley M Mellor

Journal article  |  2016  |  Journal of the American College of Cardiology

Diabetic Cardiomyopathy: The Case for a Role of Fructose in Disease Etiology

Lea MD Delbridge, Vicky L Benson, Rebecca H Ritchie, Kimberley M Mellor

Journal article  |  2016  |  Diabetes

BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle

Tahnee L Kennedy, Kristy Swiderski, Kate T Murphy, Stefan M Gehrig, Claire L Curl, Chanchal Chandramouli, Mark A Febbraio, Lea MD Delbridge, Rene Koopman, Gordon S Lynch

Journal article  |  2016  |  AMERICAN JOURNAL OF PATHOLOGY

Dietary omega-6 fatty acid replacement selectively impairs cardiac functional recovery after ischemia in female (but not male) rats

Wendy TK Ip, Andrew McAlindon, Sarah E Miller, James R Bell, Claire L Curl, Catherine E Huggins, Kimberley M Mellor, Antonia JA Raaijmakers, Laura A Bienvenu, Peter L McLennan, Salvatore Pepe, Lea MD Delbridge

Journal article  |  2016  |  American Journal of Physiology-Heart and Circulatory Physiology

Male and female hypertrophic rat cardiac myocyte functional responses to ischemic stress and beta-adrenergic challenge are different

James R Bell, Claire L Curl, Tristan W Harding, Martin Vila Petroff, Stephen B Harrap, Lea MD Delbridge

Journal article  |  2016  |  Biology of Sex Differences

Mitochondrial fission - a drug target for cytoprotection or cytodestruction?

Ayeshah A Rosdah, Jessica K Holien, Lea MD Delbridge, Gregory J Dusting, Shiang Y Lim

Journal article  |  2016  |  Pharmacology Research & Perspectives

Tripartite motif-containing 55 identified as functional candidate for spontaneous cardiac hypertrophy in the rat locus cardiac mass 22.

G LOPEZ CAMPOS, PR Prestes, FZ Marques, SA Booth, M McGlynn, P Lewandowski, LM Dellbridge, SB Harrap, FJ Charchar

Journal article  |  2016  |  Journal of Hypertension

Telomere dynamics during aging in polygenic left ventricular hypertrophy

Francine Z Marques, Scott A Booth, Priscilla R Prestes, Claire L Curl, Lea MD Delbridge, Paul Lewandowski, Stephen B Harrap, Fadi J Charchar

Journal article  |  2016  |  Physiological Genomics

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adams, Peter D Adams, Khosrow Adeli, Peter J Adhihetty, Sharon G Adler, Galila Agam, Rajesh Agarwal, Manish K Aghi, Maria Agnello, Patrizia Agostinis, Patricia V Aguilar, Julio Aguirre-Ghiso, Edoardo M Airoldi, et al.

Journal article  |  2016  |  Autophagy

CaMKII delta and cardiomyocyte Ca2 signalling new perspectives on splice variant targeting

James R Bell, Antonia JA Raaijmakers, Johannes V Janssens, Lea MD Delbridge

Journal article  |  2015  |  Clinical and Experimental Pharmacology and Physiology

Cardiomyocyte Mineralocorticoid Receptor Activation Impairs Acute Cardiac Functional Recovery After Ischemic Insult

Laura A Bienvenu, Melissa E Reichelt, James Morgan, Elizabeth K Fletcher, James R Bell, Amanda J Rickard, Lea M Delbridge, Morag J Young

Journal article  |  2015  |  Hypertension

The role of CaMKII in diabetic heart dysfunction

Lorna Daniels, James R Bell, Lea MD Delbridge, Fiona J McDonald, Regis R Lamberts, Jeffrey R Erickson

Journal article  |  2015  |  Heart Failure Reviews

Myocardial autophagic energy stress responses-macroautophagy, mitophagy, and glycophagy

Lea MD Delbridge, Kimberley M Mellor, David JR Taylor, Roberta A Gottlieb

Journal article  |  2015  |  American Journal of Physiology-Heart and Circulatory Physiology

Glucose as an agent of post-translational modification in diabetes - New cardiac epigenetic insights

Kimberley M Mellor, Margaret A Brimble, Lea MD Delbridge

Journal article  |  2015  |  Life Sciences

Epigenetics and cardiovascular disease

Lea MD Delbridge, Kimberley M Mellor, Loren E Wold

Journal article  |  2015  |  Life Sciences

Myocardial glycogen dynamics: New perspectives on disease mechanisms

Chanchal Chandramouli, Upasna Varma, Ellie M Stevens, Rui-Ping Xiao, David I Stapleton, Kimberley M Mellor, Lea MD Delbridge

Journal article  |  2015  |  Clinical and Experimental Pharmacology and Physiology

Myocardial and Cardiomyocyte Stress Resilience Is Enhanced in Aromatase-Deficient Female Mouse Hearts Through CaMKII delta Activation

James R Bell, Gabriel B Bernasochi, Amanda C Wollermann, Antonia JA Raaijmakers, Wah Chin Boon, Evan R Simpson, Claire L Curl, Kimberley M Mellor, Lea MD Delbridge

Journal article  |  2015  |  Endocrinology

Cardiac CaMKII delta splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart

James R Bell, Antonia JA Raaijmakers, Claire L Curl, Melissa E Reichelt, TristanW Harding, Aier Bei, Dominic CH Ng, Jeffrey R Erickson, Martin Vila Petroff, Stephen B Harrap, Lea MD Delbridge

Journal article  |  2015  |  International Journal of Cardiology

Ca2 /calmodulin dependent kinase II: A critical mediator in determining reperfusion outcomes in the heart?

James R Bell, Jeffrey R Erickson, Lea MD Delbridge

Journal article  |  2014  |  Clinical and Experimental Pharmacology and Physiology

Ageing-related cardiomyocyte functional decline is sex and angiotensin II dependent

Kimberley M Mellor, Claire L Curl, Chanchal Chandramouli, Thierry Pedrazzini, Igor R Wendt, Lea MD Delbridge

Journal article  |  2014  |  AGE

CaMKII-dependent responses to ischemia and reperfusion challenges in the heart

James R Bell, Martin Vila-Petroff, Lea MD Delbridge

Journal article  |  2014  |  Frontiers in Pharmacology

Aromatase transgenic upregulation modulates basal cardiac performance and the response to ischemic stress in male mice

James R Bell, Gabriel B Bernasochi, Upasna Varma, Wah Chin Boon, Stuart J Ellem, Gail P Risbridger, Lea MD Delbridge

Journal article  |  2014  |  American Journal of Physiology - Heart and Circulatory Physiology

HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy models

Kim L Powell, Nigel C Jones, Jeremy T Kennard, Caroline Ng, Vijay Urmaliya, Shannen Lau, Adora Tran, Thomas Zheng, Ezgi Ozturk, Gabi Dezsi, Ika Megatia, Lea M Delbridge, Didier Pinault, Christopher A Reid, Paul J White, Terence J O'Brien

Journal article  |  2014  |  Epilepsia

Cardiomyocyte glycophagy is regulated by insulin and exposure to high extracellular glucose

Kimberley M Mellor, Upasna Varma, David I Stapleton, Lea MD Delbridge

Journal article  |  2014  |  American Journal of Physiology - Heart and Circulatory Physiology

Myocardial glycophagy - A specific glycogen handling response to metabolic stress is accentuated in the female heart

ME Reichelt, KM Mellor, CL Curl, D Stapleton, LMD Delbridge

Journal article  |  2013  |  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardioprotective 3 ',4 '-dihydroxyflavonol attenuation of JNK and p38(MAPK) signalling involves CaMKII inhibition

Nicholas R Lim, Colleen J Thomas, Lokugan S Silva, Yvonne Y Yeap, Suwan Yap, James R Bell, Lea MD Delbridge, Marie A Bogoyevitch, Owen L Woodman, Spencer J Williams, Clive N May, Dominic CH Ng

Journal article  |  2013  |  BIOCHEMICAL JOURNAL

Mineralocorticoid receptors and the heart, multiple cell types and multiple mechanisms: a focus on the cardiomyocyte

Laura A Bienvenu, Melissa E Reichelt, Lea MD Delbridge, Morag J Young

Journal article  |  2013  |  Clinical Science

Sex, sex steroids, and diabetic cardiomyopathy: making the case for experimental focus

Melissa E Reichelt, Kimberley M Mellor, James R Bell, Chanchal Chandramouli, John P Headrick, Lea MD Delbridge

Journal article  |  2013  |  American Journal of Physiology - Heart and Circulatory Physiology

Sex and sex hormones in cardiac stress-Mechanistic insights

James R Bell, Gabriel B Bernasochi, Upasna Varma, Antonia JA Raaijmakers, Lea MD Delbridge

Journal article  |  2013  |  Journal of Steroid Biochemistry and Molecular Biology

The adenosine A(2A) receptor - Myocardial protectant and coronary target in endotoxemia

Melissa E Reichelt, Kevin J Ashton, Xing Lin Tan, S Jamal Mustafa, Catherine Ledent, Lea MD Delbridge, Polly A Hofmann, John P Headrick, R Ray Morrison

Journal article  |  2013  |  International Journal of Cardiology

Autophagic predisposition in the insulin resistant diabetic heart

Kimberley M Mellor, Melissa E Reichelt, Lea MD Delbridge

Journal article  |  2013  |  Life Sciences

Ca2 -dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle

RM Murphy, TL Dutka, D Horvath, JR Bell, LM Delbridge, GD Lamb

Journal article  |  2013  |  Journal of Physiology

Myocardial insulin resistance, metabolic stress and autophagy in diabetes

Kimberley M Mellor, James R Bell, Rebecca H Ritchie, Lea MD Delbridge

Journal article  |  2013  |  Clinical and Experimental Pharmacology and Physiology

Cardiomyocyte Mineralocorticoid Receptors Are Essential for Deoxycorticosterone/Salt-Mediated Inflammation and Cardiac Fibrosis

Amanda J Rickard, James Morgan, Laura A Bienvenu, Elizabeth K Fletcher, Greg A Cranston, Jimmy Z Shen, Melissa E Reichelt, Lea M Delbridge, Morag J Young

Journal article  |  2012  |  HYPERTENSION

Ca2 /calmodulin-dependent protein kinase inhibition suppresses post-ischemic arrhythmogenesis and mediates sinus bradycardic recovery in reperfusion

James R Bell, Claire L Curl, Wendy TK Ip, Lea MD Delbridge

Journal article  |  2012  |  International Journal of Cardiology

Macrophage Mineralocorticoid Receptor Signaling Plays a Key Role in Aldosterone-Independent Cardiac Fibrosis

Laura A Bienvenu, James Morgan, Amanda J Rickard, Greg H Tesch, Greg A Cranston, Elizabeth K Fletcher, Lea MD Delbridge, Morag J Young

Journal article  |  2012  |  ENDOCRINOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J Klionsky, Fabio C Abdalla, Hagai Abeliovich, Robert T Abraham, Abraham Acevedo-Arozena, Khosrow Adeli, Lotta Agholme, Maria Agnello, Patrizia Agostinis, Julio A Aguirre-Ghiso, Hyung Jun Ahn, Ouardia Ait-Mohamed, Slimane Ait-Si-Ali, Takahiko Akematsu, Shizuo Akira, Hesham M Al-Younes, Munir A Al-Zeer, Matthew L Albert, Roger L Albin, Javier Alegre-Abarrategui, et al.

Journal article  |  2012  |  Autophagy

Fructose diet treatment in mice induces fundamental disturbance of cardiomyocyte Ca2 handling and myofilament responsiveness

Kimberley M Mellor, Igor R Wendt, Rebecca H Ritchie, Lea MD Delbridge

Journal article  |  2012  |  American Journal of Physiology - Heart and Circulatory Physiology

Macrophage Mineralocorticoid Receptor Signalling plays a key role in Aldosterone-Independent Cardiac Fibrosis

L BIENVENU, J Morgan, A Rickard, G Tesch, G Cranston, E Fletcher, LM Delbridge, M Young

Journal article  |  2012  |  Endocrinology

Insulin-like growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia

Cecilia M Prele, Melissa E Reichelt, Steven E Mutsaers, Marilyn Davies, Lea M Delbridge, John P Headrick, Nadia Rosenthal, Marie A Bogoyevitch, Miranda D Grounds

Journal article  |  2012  |  CARDIOVASCULAR PATHOLOGY

'Gain'-ful insight into the cardiomyocyte Ca2 seX factor

Claire L Curl, James R Bell, Lea MD Delbridge

Journal article  |  2012  |  Journal of Molecular and Cellular Cardiology

Aromatase Deficiency Confers Paradoxical Postischemic Cardioprotection

James R Bell, Kimberley M Mellor, Amanda C Wollermann, Wendy TK Ip, Melissa E Reichelt, Sarah J Meachem, Evan R Simpson, Lea MD Delbridge

Journal article  |  2011  |  Endocrinology

Heteromerization of angiotensin receptors changes trafficking and arrestin recruitment profiles

Enzo R Porrello, Kevin DG Pfleger, Ruth M Seeber, Hongwei Qian, Cristina Oro, Fe Abogadie, Lea MD Delbridge, Walter G Thomas

Journal article  |  2011  |  Cellular Signaling

Cardiac ischaemic stress: Cardiomyocyte Ca2 , sex and sex steroids

James R Bell, Kimberley M Mellor, Amanda C Wollermann, Lea MD Delbridge

Journal article  |  2011  |  Clinical and Experimental Pharmacology and Physiology

Autophagy anomalies in the diabetic myocardium

Kimberley M Mellor, Melissa E Reichelt, Lea MD Delbridge

Journal article  |  2011  |  Autophagy

Regulation of angiotensinogen by angiotensin II in mouse primary astrocyte cultures

EL O'Callaghan, JK Bassi, ER Porrello, LMD Delbridge, WG Thomas, AM Allen

Journal article  |  2011  |  Journal of Neurochemistry

Fructose Modulates Cardiomyocyte Excitation-Contraction Coupling and Ca2 Handling In Vitro

Kimberley M Mellor, James R Bell, Igor R Wendt, Amy J Davidoff, Rebecca H Ritchie, Lea MD Delbridge

Journal article  |  2011  |  PLoS One

Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice

Kimberley M Mellor, James R Bell, Morag J Young, Rebecca H Ritchie, Lea MD Delbridge

Journal article  |  2011  |  Journal of Molecular and Cellular Cardiology

Evaluating RNA Preparation Options for Archived Myocardial Biopsies

Wendy TK Ip, Catherine E Huggins, Salvatore Pepe, Lea MD Delbridge

Journal article  |  2011  |  Heart, Lung and Circulation

High-fructose diet elevates myocardial superoxide generation in mice in the absence of cardiac hypertrophy

Kimberley Mellor, Rebecca H Ritchie, Greta Meredith, Owen L Woodman, Margaret J Morris, Lea MD Delbridge

Journal article  |  2010  |  NUTRITION

Elevated dietary sugar and the heart: experimental models and myocardial remodeling

Kimberley M Mellor, Rebecca H Ritchie, Amy J Davidoff, Lea MD Delbridge

Journal article  |  2010  |  Canadian Journal of Physiology and Pharmacology

Targeted GLUT-4 deficiency in the heart induces cardiomyocyte hypertrophy and impaired contractility linked with Ca2 and proton flux dysregulation

Andrea A Domenighetti, Vennetia R Danes, Claire L Curl, Jennifer M Favaloro, Joseph Proietto, Lea MD Delbridge

Journal article  |  2010  |  Journal of Molecular and Cellular Cardiology

Reactive oxygen species and insulin-resistant cardiomyopathy

Kimberley M Mellor, Rebecca H Ritchie, Lea MD Delbridge

Journal article  |  2010  |  Clinical and Experimental Pharmacology and Physiology

Glucocorticoids Suppress Growth in Neonatal Cardiomyocytes Co-Expressing AT(2) and AT(1) Angiotensin Receptors

Enzo R Porrello, William F Meeker, Walter G Thomas, Robert E Widdop, Lea MD Delbridge

Journal article  |  2010  |  Neonatology: foetal and neonatal research

Erratum: Angiotensin II-mediated adaptive and maladaptive remodeling of cardiomyocyte excitation-contraction coupling (Circulation Research (2009) 105 (42-50))

K Gusev, AA Domenighetti, LMD Delbridge, T Pedrazzini, E Niggli, M Egger

Journal article  |  2009  |  Circulation Research

Cardiomyocyte autophagy is regulated by angiotensin II type 1 and type 2 receptors

Enzo R Porrello, Lea MD Delbridge

Journal article  |  2009  |  Autophagy

Angiotensin II-Mediated Adaptive and Maladaptive Remodeling of Cardiomyocyte Excitation-Contraction Coupling

Konstantin Gusev, Andrea A Domenighetti, Lea MD Delbridge, Thierry Pedrazzini, Ernst Niggli, Marcel Egger

Journal article  |  2009  |  Circulation Research

Angiotensin II: a regulator of cardiomyocyte function and survival

Julieta Palomeque, Leanne Delbridge, Martin Vila Petroff

Journal article  |  2009  |  Frontiers in Bioscience

Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor-Mediated Cardiomyocyte Autophagy

Enzo R Porrello, Angelo D'Amore, Claire L Curl, Andrew M Allen, Stephen B Harrap, Walter G Thomas, Lea MD Delbridge

Journal article  |  2009  |  Hypertension

Dietary fish oil is antihypertrophic but does not enhance postischemic myocardial function in female mice

Catherine E Huggins, Claire L Curl, Ruchi Patel, Peter L McLennan, Mandy L Theiss, Thierry Pedrazzini, Salvatore Pepe, Lea MD Delbridge

Journal article  |  2009  |  American Journal of Physiology - Heart and Circulatory Physiology

Cell volume control in phospholemman (PLM) knockout mice: do cardiac myocytes demonstrate a regulatory volume decrease and is this influenced by deletion of PLM ?

James R Bell, David Lloyd, Claire L Curl, Lea MD Delbridge, Michael J Shattock

Journal article  |  2009  |  Experimental Physiology

Heritable pathologic cardiac hypertrophy in adulthood is preceded by neonatal cardiac growth restriction

Enzo R Porrello, James R Bell, Jonathan D Schertzer, Claire L Curl, Julie R McMullen, Kimberley M Mellor, Rebecca H Ritchie, Gordon S Lynch, Stephen B Harrap, Walter G Thomas, Lea MD Delbridge

Journal article  |  2009  |  American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

The angiotensin II type 2 (AT(2)) receptor: an enigmatic seven transmembrane receptor

Enzo R Porrello, Lea MD Delbridge, Walter G Thomas

Journal article  |  2009  |  Frontiers in Bioscience

Cardiomyocyte autophagy is regulated by angiotensin II type 1 and type 2 receptors

E Porrello, L DELBRIDGE

Journal article  |  2009  |  Autophagy

Testosterone Modulates Cardiomyocyte Ca2 Handling and Contractile Function

CL Curl, LMD Delbridge, BJ Canny, IR Wendt

Journal article  |  2009  |  Physiological Research

Benchmarking Ventricular Arrhythmias in the Mouse-Revisiting the 'Lambeth Conventions' 20 Years On

Catherine E Huggins, James R Bell, Salvatore Pepe, Lea MD Delbridge

Journal article  |  2008  |  Heart, Lung & Circulation

EARLY ORIGINS OF CARDIAC HYPERTROPHY: DOES CARDIOMYOCYTE ATTRITION PROGRAMME FOR PATHOLOGICAL 'CATCH-UP' GROWTH OF THE HEART?

Enzo R Porrello, Robert E Widdop, Lea MD Delbridge

Journal article  |  2008  |  Clinical and Experimental Pharmacology and Physiology

Sex differences in cardiac muscle responsiveness to Ca2 and L-type Ca2 channel modulation

Claire L Curl, Lea MD Delbridge, Igor R Wendt

Journal article  |  2008  |  European Journal of Pharmacology

Myocardial gene expression associated with genetic cardiac hypertrophy in the absence of hypertension

Jeremy P Dwyer, Matthew E Ritchie, Gordon K Smyth, Stephen B Harrap, Lea MD Delbridge, Andrea A Domenighetti, Robert Di Nicolantonio

Journal article  |  2008  |  Hypertension Research

The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy

James R Bell, Enzo R Porrello, Catherine E Huggins, Stephen B Harrap, Lea MD Delbridge

Journal article  |  2008  |  American Journal of Physiology - Heart and Circulatory Physiology

Functional and metabolic remodelling in GLUT4-deficient hearts confers hyper-responsiveness to substrate intervention

CE Huggins, AA Domenighetti, ME Ritchie, N Khalil, JM Favaloro, J Proietto, GK Smyth, S Pepe, LMD Delbridge

Journal article  |  2008  |  Journal of Molecular and Cellular Cardiology

Functional and metabolic remodelling in GLUT4-deficient hearts confers hyper-responsiveness to substrate intervention

CE Huggins, AA Domenighetti, ME Ritchie, N Khalil, JM Favaloro, J Proletto, GK Smyth, S Pepe, LMD Delbridge

Journal article  |  2008  |  Journal of Molecular and Cellular Cardiology

Quantitative polarized phase microscopy for birefringence imaging

Nicoleta M Dragomir, Xiao M Goh, Claire L Curl, Lea MD Delbridge, Ann Roberts

Journal article  |  2007  |  Optics Express

Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpression

Olivier WV Van den Brink, Lea M Durham Delbridge, Thierry Pedrazzini, Franklin L Rosenfeldt, Salvatore Pepe

Journal article  |  2007  |  Journal of Renin-Angiotensin-Aldosterone System

Pacemaker cell and atrial function: unravelling how calcium initiates and regulates the heart beat and how ionic dysfunction, 'channelopathies' and other membrane remodelling contribute to atrial fibrillation.

Salvatore Pepe, Lea MD Delbridge

Journal article  |  2007  |  Heart, Lung & Circulation

Sex differences in murine myocardial membrane lipid composition modulate growth and postischemic arrhythmia

Catherine E Huggins, Peter L McLennar, Mandy L Theiss, Thierry Pedrazzini, Salvatore Pepe, Leanne MD Delbridge

Conference Proceedings  |  2007  |  Journal of Molecular and Cellular Cardiology

The antioxidant tempol inhibits cardiac hypertrophy in the insulin-resistant GLUT4-deficient mouse in vivo

RH Ritchie, JM Quinn, AH Cao, GR Drummond, DM Kaye, JM Favaloro, J Proietto, LMD Delbridge

Journal article  |  2007  |  Journal of Molecular and Cellular Cardiology

The antioxidant tempol inhibits cardiac hypertrophy in the insulin-resistant GLUT4-deficient mouse in vivo

RH Ritchie, JM Quinn, AH Cao, GR Drummond, DM Kaye, JM Favaloro, J Proietto, LMD Delbridge

Journal article  |  2007  |  Journal of Molecular and Cellular Cardiology

Cardiomycytes birefingence imaging: simultaneous phase and retardation 2D measurements

N DRAGOMIR, A ROBERTS, L DELBRIDGE

Journal article  |  2007  |  G I T Imaging & Microscopy

Single cell volume measurement by quantitative phase microscopy (QPM): A case study of erythrocyte morphology

Claire L Curl, Catherine J Bellair, Peter J Harris, Brendan E Allman, Ann Roberts, Keith A Nugent, Lea MD Delbridge

Journal article  |  2006  |  Cellular Physiology and Biochemistry

Cardiac hypertrophy, substrate utilization and metabolic remodelling: Cause or effect?

RH Ritchie, LMD Delbridge

Journal article  |  2006  |  Clinical and Experimental Pharmacology and Physiology

Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure

AA Domenighetti, Q Wang, M Egger, SM Richards, T Pedrazzini, LMD Delbridge

Journal article  |  2005  |  Hypertension

Refractive index measurement in viable cells using quantitative phase-amplitude microscopy and confocal microscopy

CL Curl, CJ Bellair, T Harris, BE Allman, PJ Harris, AG Stewart, A Roberts, KA Nugent, LMD Delbridge

Journal article  |  2005  |  Cytometry Part A

Elevated dietary sodium intake exacerbates myocardial hypertrophy associated with cardiac-specific overproduction of angiotensin II

ER Porrello, CE Huggins, CL Curl, AA Domenighetti, T Pedrazzini, LMD Delbridge, TO Morgan

Journal article  |  2004  |  Journal of Renin-Angiotensin-Aldosterone System

Quantitative phase microscopy: A new tool for investigating the structure and function of unstained live cells

CL Curl, CJ Bellair, PJ Harris, BE Allman, A Roberts, KA Nugent, LMD Delbridge

Journal article  |  2004  |  Clinical and Experimental Pharmacology and Physiology

Transitory reduction in angiotensin AT(2) receptor expression levels in postinfarct remodelling in rat myocardium

CJ Lax, AA Domenighetti, JM Pavia, R Di Nicolantonio, CL Curl, MJ Morris, LMD Delbridge

Journal article  |  2004  |  Clinical and Experimental Pharmacology and Physiology

Development of colorectal sensitization is associated with increased eosinophils and mast cells in dextran sulfate sodium-treated rats

JM Tobin, LMD Delbridge, R Di Nicolantonio, P Bhathal

Journal article  |  2004  |  Digestive Diseases and Sciences

Vascular and brain neuropeptide Y in banded and spontaneously hypertensive rats

MJ Morris, CF Tortelli, DP Hart, LMD Delbridge

Journal article  |  2004  |  Peptides

Quantitative phase microscopy: a new tool for measurement of cell culture growth and confluency in situ

CL Curl, T Harris, PJ Harris, BE Allman, CJ Bellair, AG Stewart, LMD Delbridge

Journal article  |  2004  |  Pflugers Archiv - European Journal of Physiology

Quantitative phase amplitude microscopy IV: imaging thick specimens

CJ Bellair, CL Curl, BE Allman, PJ Harris, A Roberts, LMD Delbridge, KA Nugent

Journal article  |  2004  |  Journal of Microscopy - Oxford

Putting the heart through its paces - cellular insights from frequency phenomena

LM DELBRIDGE, CL CURL

Journal article  |  2004  |  Heart, Lung & Circulation

Combined renin-angiotensin system blockade and dietary sodium restriction impairs cardiomyocyte contractility

P Trongtorsak, TO Morgan, LM Delbridge

Journal article  |  2003  |  Journal of Renin-Angiotensin-Aldosterone System

Threshold effects of glucose transporter-4 (GLUT4) deficiency on cardiac glucose uptake and development of hypertrophy

SJ Kaczmarczyk, S Andrikopoulos, J Favaloro, AA Domenighetti, A Dunn, M Ernst, D Grail, M Fodero-Tavoletti, CE Huggins, LM Delbridge, JD Zajac, J Proietto

Journal article  |  2003  |  Journal of Molecular Endocrinology

Elevated intracardiac angiotensin II leads to cardiac hypertrophy and mechanical dysfunction in normotensive mice

CE Huggins, AA Domenighetti, T Pedrazzini, S Pepe, LMD Delbridge

Journal article  |  2003  |  Journal of Renin-Angiotensin-Aldosterone System

Endogenous cardiac opioids: enkephalins in adaptation and protection of the heart.

Olivier WV van den Brink, Lea M Delbridge, Franklin L Rosenfeldt, Daniel Penny, Donald S Esmore, Deahne Quick, David M Kaye, Salvatore Pepe

Journal article  |  2003  |  Heart, Lung & Circulation

Opiates have been used for thousands of years in the form of opium for relief of pain or fever and to induce sleep. However, it wa..

Evolution of a student model-building program

DA Weaver, RE Kemm, T Petrovic, T Gilding, PJ Harris, L Delbridge

Journal article  |  2002  |  Advances in Physiology Education

Low doses of angiotensin converting enzyme inhibitors and angiotensin type 1 blockers have a synergistic effect but: High doses are less than additive

T Morgan, C Griffiths, L Delbridge

Journal article  |  2002  |  American Journal of Hypertension

The hypertrophic heart rat: a new normotensive model of genetic cardiac and cardiomyocyte hypertrophy

SB Harrap, VR Danes, JA Ellis, CD Griffiths, EF Jones, LMD Delbridge

Journal article  |  2002  |  Physiological Genomics

Interaction of ACE inhibitors and AT(1)-receptor blockers on maximum blood pressure response in spontaneous hypertensive rats

T Morgan, C Griffiths, L Delbridge

Journal article  |  2002  |  Journal of Renin-Angiotensin-Aldosterone System

Quantitative phase imaging - A new way to 'see' cells

LMD Delbridge, AA Kabbara, C Bellair, BE Allman, L Nassis, A Roberts, KA Nugent

Journal article  |  2002  |  Today's Life Science

Evolution of a student model-building program

DA Weaver, RE Kemm, T Petrovic, T Gilding, PJ Harris, L Delbridge

Journal article  |  2002  |  American Journal of Physiology - Advances in Physiology Education

Optical Phase Microscopy: Quantitative Imaging and Conventional Phase Analogs

BE ALLMAN, L NASSIS, M VON BIBRA, CJ BELLAIR, AAH KABBARA, ED BARONE-NUGENT, AP GAETH, LM DELBRIDGE, KA NUGENT

Journal article  |  2002  |  Microscopy and Analysis

Effects of combined administration of ACE inhibitor and angiotensin II receptor antagonist are prevented by a high NaCl intake

CD Griffiths, TO Morgan, LMD Delbridge

Journal article  |  2001  |  Journal of Hypertension

Regression of cardiac hypertrophy in the SHR by combined renin-angiotensin system blockade and dietary sodium restriction

E Abro, CD Griffiths, TO Morgan, LMD Delbridge

Journal article  |  2001  |  Journal of Renin-Angiotensin-Aldosterone System

Angiotensin II: A proven therapeutic target with some mechanistic mysteries

LMD Delbridge

Journal article  |  2001  |  Heart, Lung & Circulation

Evolution of a student model building program designed to assist understanding of Biological Control Systems

DA WEAVER-COWDROY, RE KEMM, T GILDING, T PETROVIC, PJ HARRIS, LM DELBRIDGE

Conference Proceedings  |  2001  |  Proceedings of Ed-Media 2001 World Conference on Educational Multimedia, Hypermedia & Telecommunications

Wall stress, Angiotensin II, and Left Ventricular Hypertrophy

TO MORGAN, CD GRIFFITHS, LM DELBRIDGE

Book Chapter  |  2001

Downregulation of the p75 neurotrophin receptor in tissue culture and in vivo, using beta-cyclodextrin-adamantane-oligonucleotide conjugates

WR Epa, U Greferath, A Shafton, P Rong, LM Delbridge, A Bennie, GL Barrett

Journal article  |  2000  |  Antisense and Nucleic Acid Drug Development

Stimulus interval-dependent differences in Ca2 transients and contractile responses of diabetic rat cardiomyocytes.

G Kotsanas, LM Delbridge, IR Wendt

Journal article  |  2000  |  Cardiovascular Research

OBJECTIVE: The aim of this study was to gain further insights into the consequences of insulin-dependent diabetes mellitus on card..

Ethanol effects on cardiomyocyte contractility.

LM Delbridge, PJ Connell, PJ Harris, TO Morgan

Journal article  |  2000  |  Clinical Science

Little is known about the direct cardiac effects of socially common sub-intoxication levels of ethanol. Previous studies evaluatin..

Cardiac hypertrophy depends upon sleep blood pressure: a study in rats.

TO Morgan, HR Brunner, JF Aubert, Q Wang, C Griffiths, L Delbridge

Journal article  |  2000  |  Journal of Hypertension

OBJECTIVE: The objective of this study was to determine whether cardiac hypertrophy in hypertensive rats could be reduced and norm..

Angiotensin blocking drugs and the heart beyond 2000.

TO Morgan, LM Delbridge

Journal article  |  1999  |  Journal of the American Society of Nephrology

Cardiac hypertrophy can be caused in different ways, and the effect of hypertrophy on prognosis depends on whether it is concentri..

Cardiodepressant effects of interferon-gamma and endotoxin reversed by inhibition of NO synthase 2 in rat myocardium.

X Sun, LM Delbridge, GJ Dusting

Journal article  |  1998  |  Journal of Molecular and Cellular Cardiology

Endogenous nitric oxide (NO) signalling pathways within the myocardium depress myocardial contractile function in septic shock and..

Cardiac myocyte volume, Ca2 fluxes, and sarcoplasmic reticulum loading in pressure-overload hypertrophy

LMD Delbridge, H Satoh, W Yuan, JWM Bassani, QI Ming, KS Ginsburg, AM Samarel, DM Bers

Journal article  |  1997  |  American Journal of Physiology - Heart and Circulatory Physiology

Cardiac myocyte volume, Ca2 fluxes, and sarcoplasmic reticulum loading in pressure-overload hypertrophy.

LM Delbridge, H Satoh, W Yuan, JW Bassani, M Qi, KS Ginsburg, AM Samarel, DM Bers

Journal article  |  1997  |  American Journal of Physiology-Heart and Circulatory Physiology

Alterations in cellular Ca2+ transport and excitation-contraction coupling may contribute to dysfunction in cardiac hypertrophy. L..

Optical methods to evaluate the contractile function of unloaded isolated cardiac myocytes.

LM Delbridge, KP Roos

Journal article  |  1997  |  Journal of Molecular and Cellular Cardiology

The enzymatically isolated cardiac myocyte has achieved prominence as an experimental model of myocardial excitation contraction c..

Contractile function of cardiomyocytes from the spontaneously hypertensive rat.

LM Delbridge, PJ Connell, TO Morgan, PJ Harris

Journal article  |  1996  |  Journal of Molecular and Cellular Cardiology

In essential hypertension it has been hypothesized that there is a generalized derangement in cellular Ca2+ homeostasis. The aim o..

Surface:volume relationship in cardiac myocytes studied with confocal microscopy and membrane capacitance measurements: species-dependence and developmental effects.

H Satoh, LM Delbridge, LA Blatter, DM Bers

Journal article  |  1996  |  Biophysical Journal

The quantitative analysis of the contribution of ion fluxes through membrane channels to changes of intracellular ion concentratio..

Steady-state twitch Ca2 fluxes and cytosolic Ca2 buffering in rabbit ventricular myocytes.

LM Delbridge, JW Bassani, DM Bers

Journal article  |  1996  |  American Journal of Physiology-Cell Physiology

Intracellular Ca2+ ([Ca2+]i) transients and transsarcolemmal Ca2+ currents were measured in indo 1-loaded isolated rabbit ventricu..

Effects of endothelin-1 on the contractility of cardiomyocytes from the spontaneously hypertensive rat.

LM Delbridge, TO Morgan, PJ Harris

Journal article  |  1995  |  Clinical and Experimental Pharmacology and Physiology

1. Disturbances in cardiovascular responsiveness to endogenous endothelin-1 (ET-1) may play a significant role in the pathogenesis..

PLATELET-ACTIVATING-FACTOR AND WEB-2086 DIRECTLY MODULATE RAT CARDIOMYOCYTE CONTRACTILITY

LM DELBRIDGE, AG STEWART, CM GOULTER, TO MORGAN, PJ HARRIS

Journal article  |  1994  |  Journal of Molecular and Cellular Cardiology

Spontaneous and propagated calcium release in isolated cardiac myocytes viewed by confocal microscopy

DA Williams, LM Delbridge, SH Cody, PJ Harris, TO Morgan

Journal article  |  1992  |  American Journal of Physiology - Cell Physiology

A superfusion bath for single-cell recording with high-precision optical depth control, temperature regulation, and rapid solution switching.

LM Delbridge, PJ Harris, JT Pringle, LJ Dally, TO Morgan

Journal article  |  1990  |  Pfl�gers Archiv European Journal of Physiology

A superfusion system for isolated cell recording, which uses a novel optical technique for feedback control of solution depth (+/-..

Characterization of single heart cell contractility by rapid imaging.

LM Delbridge, PJ Harris, TO Morgan

Journal article  |  1989  |  Clinical and Experimental Pharmacology and Physiology

1. A rapid imaging technique with temporal resolution of about 1 ms was employed to describe cell-length changes during the isoton..

Rapid measurement of isolated cardiac muscle cell length using a line-scan camera.

PJ Harris, D Stewart, MC Cullinan, LM Delbridge, L Dally, P Grinwald

Journal article  |  1987  |  IEEE Transactions on Biomedical Engineering

Heterogeneity of the action potential in isolated rat ventricular myocytes and tissue.

T Watanabe, LM Delbridge, JO Bustamante, TF McDonald

Journal article  |  1983  |  Circulation Research

The objectives of this study were to measure action potential parameters in enzyme-dissociated, adult rat ventricular myocytes sti..

An ultrastructural investigation into the size dependency of contractility of isolated cardiac muscle.

LM Delbridge, DS Loiselle

Journal article  |  1981  |  Cardiovascular Research

The maximal stress (force per cross-sectional area), maximal rate of stress development, and cross-sectional area of 30 rabbit rig..