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Cardiomyocyte functional screening: interrogating comparative electrophysiology of high-th..
Diabetic Cardiomyopathy - New Molecular Intervention Targets And A Biomarker Strategy
HFpEF-Time to Explore the Role of Genetic Heterogeneity in Phenotypic Variability New Mech..
Displaying the 27 most recent projects by Lea Delbridge.
Internal Research Grant
Displaying the 153 most recent scholarly works by Lea Delbridge.
Cardiomyocyte functional screening: interrogating comparative electrophysiology of high-throughput model cell systems
Simon P Wells, Helen M Waddell, Choon Boon Sim, Shiang Y Lim, Gabriel B Bernasochi, Davor Pavlovic, Paulus Kirchhof, Enzo R Porrello, Lea MD Delbridge, James R Bell
Journal article | 2019 | American Journal of Physiology-Cell Physiology
Cardiac arrhythmias of both atrial and ventricular origin are an important feature of cardiovascular disease. Novel anti-arrhythmi..
Impact of Estrogens on the Regulation of White, Beige, and Brown Adipose Tissue Depots
Gabriel B Bernasochi, James R Bell, Evan R Simpson, Lea MD Delbridge, Wah Chin Boon
Journal article | 2019 | Comprehensive Physiology
As adipose tissue depots are active endocrine organs, they secrete a variety of hormones (including estrogens from white adipose) ..
Cardiomyocyte transcription is controlled by combined MR and circadian clock signalling.
ELizabeth K Fletcher, Monica Kanki, James Morgan, David W Ray, Lea Delbridge, Peter James Fuller, Colin D Clyne, Morag J Young
Journal article | 2019 | Journal of Endocrinology
We previously identified a critical pathogenic role for MR activation in cardiomyocytes that included a potential interaction betw..
Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture
Shouryadipta Ghosh, Kenneth Tran, Lea MD Delbridge, Anthony JR Hickey, Eric Hanssen, Edmund J Crampin, Vijay Rajagopal
Journal article | 2018 | PLOS Computational Biology
Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive-A New Preclinical Model
Claire L Curl, Vennetia R Danes, James R Bell, Antonia JA Raaijmakers, Wendy TK Ip, Chanchal Chandramouli, Tristan W Harding, Enzo R Porrello, Jeffrey R Erickson, Fadi J Charchar, Andrew R Kompa, Amanda J Edgley, David J Crossman, Christian Soeller, Kimberley M Mellor, Jonathan M Kalman, StephenB Harrap, Lea MD Delbridge
Journal article | 2018 | Journal of the American Heart Association
NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network
David J Anderson, David I Kaplan, Katrina M Bell, Katerina Koutsis, John M Haynes, Richard J Mills, Dean G Phelan, Elizabeth L Qian, Ana Rita Leitoguinho, Deevina Arasaratnam, Tanya Labonne, Elizabeth S Ng, Richard P Davis, Simona Casini, Robert Passier, James E Hudson, Enzo R Porrello, Mauro W Costa, Arash Rafii, Clare L Curl, et al.
Journal article | 2018 | Nature Communications
Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia
Chanchal Chandramouli, Melissa E Reichelt, Claire L Curl, Upasna Varma, Laura A Bienvenu, Parisa Koutsifeli, Antonia JA Raaijmakers, Miles J De Blasio, Cheng Xue Qin, Alicia J Jenkins, Rebecca H Ritchie, Kimberley M Mellor, Lea MD Delbridge
Journal article | 2018 | Scientific Reports
Mdivi-1 Protects Human W8B2( ) Cardiac Stem Cells from Oxidative Stress and Simulated Ischemia-Reperfusion Injury
Ayeshah A Rosdah, Simon T Bond, Priyadharshini Sivakumaran, Ashfaqul Hoque, Jonathan S Oakhill, Brian G Drew, Lea MD Delbridge, Shiang Y Lim
Journal article | 2017 | Stem Cells and Development
Chronic in vivo nitric oxide deficiency impairs cardiac functional recovery after ischemia in female (but not male) mice.
Laura A Bienvenu, James Morgan, Melissa E Reichelt, Lea MD Delbridge, Morag J Young
Journal article | 2017 | Journal of Molecular and Cellular Cardiology
Nitric oxide (NO) is an important regulator of cardiac function and plays a key role in ischemic cardioprotection. The role of chr..
High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice
Sarah E Heywood, Adele L Richart, Darren C Henstridge, Karen Alt, Helen Kiriazis, Claire Zammit, Andrew L Carey, Helene L Kammoun, Lea M Delbridge, Medini Reddy, Yi-Ching Chen, Xiao-Jun Du, Christoph E Hagemeyer, Mark A Febbraio, Andrew L Siebel, Bronwyn A Kingwell
Journal article | 2017 | Science Translational Medicine
Pericardial adipose and aromatase: A new translational target for aging, obesity and arrhythmogenesis?
Gabriel B Bernasochi, Wah Chin Boon, Claire L Curl, Upasna Varma, Salvatore Pepe, Marianne Tare, Laura J Parry, Evdokia Dimitriadis, Stephen B Harrap, Chrishan J Nalliah, Jonathan M Kalman, Lea MD Delbridge, James R Bell
Journal article | 2017 | Journal of Molecular and Cellular Cardiology
Deoxycorticosterone/Salt-Mediated Cardiac Inflammation and Fibrosis Are Dependent on Functional CLOCK Signaling in Male Mice.
Elizabeth K Fletcher, James Morgan, David R Kennaway, Laura A Bienvenu, Amanda J Rickard, Lea MD Delbridge, Peter J Fuller, Colin D Clyne, Morag J Young
Journal article | 2017 | Endocrinology
Activation of the mineralocorticoid receptor (MR) promotes inflammation, fibrosis, and hypertension. Clinical and experimental stu..
Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure
Francine Z Marques, Priscilla R Prestes, Sean G Byars, Scott C Ritchie, Peter Wurtz, Sheila K Patel, Scott A Booth, Indrajeetsinh Rana, Yosuke Minoda, Stuart P Berzins, Claire L Curl, James R Bell, Bryan Wai, Piyush M Srivastava, Antti J Kangas, Pasi Soininen, Saku Ruohonen, Mika Kahonen, Terho Lehtimaki, Emma Raitoharju, et al.
Journal article | 2017 | Journal of the American Heart Association
Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency
Duncan E Crombie, Claire L Curl, Antonia JA Raaijmakers, Priyadharshini Sivakumaran, Tejal Kulkarni, Raymond CB Wong, Itsunari Minami, Marguerite V Evans-Galea, Shiang Y Lim, Lea Delbridge, Louise A Corben, Mirella Dottori, Norio Nakatsuji, Ian A Trounce, Alex W Hewitt, Martin B Delatycki, Martin F Pera, Alice Pebay
Journal article | 2017 | Aging
Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications
Cheng Xue Qin, Rochelle Sleaby, Amy J Davidoff, James R Bell, Miles J De Blasio, Leanne M Delbridge, John C Chatham, Rebecca H Ritchie
Journal article | 2017 | Pharmacological Research
Changes in mitochondrial morphology and organization can enhance energy supply from mitochondrial oxidative phosphorylation in diabetic cardiomyopathy
Jan Jarosz, Shouryadipta Ghosh, Lea MD Delbridge, Amorita Petzer, Anthony JR Hickey, Edmund J Crampin, Eric Hanssen, Vijay Rajagopal
Journal article | 2017 | American Journal of Physiology-Cell Physiology
BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle
Tahnee L Kennedy, Kristy Swiderski, Kate T Murphy, Stefan M Gehrig, Claire L Curl, Chanchal Chandramouli, Mark A Febbraio, Lea MD Delbridge, Rene Koopman, Gordon S Lynch
Journal article | 2016 | The American Journal of Pathology
Dietary omega-6 fatty acid replacement selectively impairs cardiac functional recovery after ischemia in female (but not male) rats
Wendy TK Ip, Andrew McAlindon, Sarah E Miller, James R Bell, Claire L Curl, Catherine E Huggins, Kimberley M Mellor, Antonia JA Raaijmakers, Laura A Bienvenu, Peter L McLennan, Salvatore Pepe, Lea MD Delbridge
Journal article | 2016 | American Journal of Physiology-Heart and Circulatory Physiology
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adams, Peter D Adams, Khosrow Adeli, Peter J Adhihetty, Sharon G Adler, Galila Agam, Rajesh Agarwal, Manish K Aghi, Maria Agnello, Patrizia Agostinis, Patricia V Aguilar, Julio Aguirre-Ghiso, Edoardo M Airoldi, et al.
Journal article | 2016 | Autophagy
Myocardial and Cardiomyocyte Stress Resilience Is Enhanced in Aromatase-Deficient Female Mouse Hearts Through CaMKII delta Activation
James R Bell, Gabriel B Bernasochi, Amanda C Wollermann, Antonia JA Raaijmakers, Wah Chin Boon, Evan R Simpson, Claire L Curl, Kimberley M Mellor, Lea MD Delbridge
Journal article | 2015 | Endocrinology
Cardiac CaMKII delta splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart
James R Bell, Antonia JA Raaijmakers, Claire L Curl, Melissa E Reichelt, TristanW Harding, Aier Bei, Dominic CH Ng, Jeffrey R Erickson, Martin Vila Petroff, Stephen B Harrap, Lea MD Delbridge
Journal article | 2015 | International Journal of Cardiology
Aromatase transgenic upregulation modulates basal cardiac performance and the response to ischemic stress in male mice
James R Bell, Gabriel B Bernasochi, Upasna Varma, Wah Chin Boon, Stuart J Ellem, Gail P Risbridger, Lea MD Delbridge
Journal article | 2014 | American Journal of Physiology - Heart and Circulatory Physiology
HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy models
Kim L Powell, Nigel C Jones, Jeremy T Kennard, Caroline Ng, Vijay Urmaliya, Shannen Lau, Adora Tran, Thomas Zheng, Ezgi Ozturk, Gabi Dezsi, Ika Megatia, Lea M Delbridge, Didier Pinault, Christopher A Reid, Paul J White, Terence J O'Brien
Journal article | 2014 | Epilepsia
Cardioprotective 3 ',4 '-dihydroxyflavonol attenuation of JNK and p38(MAPK) signalling involves CaMKII inhibition
Nicholas R Lim, Colleen J Thomas, Lokugan S Silva, Yvonne Y Yeap, Suwan Yap, James R Bell, Lea MD Delbridge, Marie A Bogoyevitch, Owen L Woodman, Spencer J Williams, Clive N May, Dominic CH Ng
Journal article | 2013 | Biochemical Journal
The adenosine A(2A) receptor - Myocardial protectant and coronary target in endotoxemia
Melissa E Reichelt, Kevin J Ashton, Xing Lin Tan, S Jamal Mustafa, Catherine Ledent, Lea MD Delbridge, Polly A Hofmann, John P Headrick, R Ray Morrison
Journal article | 2013 | International Journal of Cardiology
Cardiomyocyte Mineralocorticoid Receptors Are Essential for Deoxycorticosterone/Salt-Mediated Inflammation and Cardiac Fibrosis
Amanda J Rickard, James Morgan, Laura A Bienvenu, Elizabeth K Fletcher, Greg A Cranston, Jimmy Z Shen, Melissa E Reichelt, Lea M Delbridge, Morag J Young
Journal article | 2012 | Hypertension
Guidelines for the use and interpretation of assays for monitoring autophagy
Daniel J Klionsky, Fabio C Abdalla, Hagai Abeliovich, Robert T Abraham, Abraham Acevedo-Arozena, Khosrow Adeli, Lotta Agholme, Maria Agnello, Patrizia Agostinis, Julio A Aguirre-Ghiso, Hyung Jun Ahn, Ouardia Ait-Mohamed, Slimane Ait-Si-Ali, Takahiko Akematsu, Shizuo Akira, Hesham M Al-Younes, Munir A Al-Zeer, Matthew L Albert, Roger L Albin, Javier Alegre-Abarrategui, et al.
Journal article | 2012 | Autophagy
Insulin-like growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia
Cecilia M Prele, Melissa E Reichelt, Steven E Mutsaers, Marilyn Davies, Lea M Delbridge, John P Headrick, Nadia Rosenthal, Marie A Bogoyevitch, Miranda D Grounds
Journal article | 2012 | Cardiovascular Pathology
Targeted GLUT-4 deficiency in the heart induces cardiomyocyte hypertrophy and impaired contractility linked with Ca2 and proton flux dysregulation
Andrea A Domenighetti, Vennetia R Danes, Claire L Curl, Jennifer M Favaloro, Joseph Proietto, Lea MD Delbridge
Journal article | 2010 | Journal of Molecular and Cellular Cardiology
Dietary fish oil is antihypertrophic but does not enhance postischemic myocardial function in female mice
Catherine E Huggins, Claire L Curl, Ruchi Patel, Peter L McLennan, Mandy L Theiss, Thierry Pedrazzini, Salvatore Pepe, Lea MD Delbridge
Journal article | 2009 | American Journal of Physiology - Heart and Circulatory Physiology
Heritable pathologic cardiac hypertrophy in adulthood is preceded by neonatal cardiac growth restriction
Enzo R Porrello, James R Bell, Jonathan D Schertzer, Claire L Curl, Julie R McMullen, Kimberley M Mellor, Rebecca H Ritchie, Gordon S Lynch, Stephen B Harrap, Walter G Thomas, Lea MD Delbridge
Journal article | 2009 | American Journal of Physiology - Regulatory, Integrative and Comparative Physiology
Threshold effects of glucose transporter-4 (GLUT4) deficiency on cardiac glucose uptake and development of hypertrophy
SJ Kaczmarczyk, S Andrikopoulos, J Favaloro, AA Domenighetti, A Dunn, M Ernst, D Grail, M Fodero-Tavoletti, CE Huggins, LM Delbridge, JD Zajac, J Proietto
Journal article | 2003 | Journal of Molecular Endocrinology
Endogenous cardiac opioids: enkephalins in adaptation and protection of the heart.
Olivier WV van den Brink, Lea M Delbridge, Franklin L Rosenfeldt, Daniel Penny, Donald S Esmore, Deahne Quick, David M Kaye, Salvatore Pepe
Journal article | 2003 | Heart, Lung & Circulation
Opiates have been used for thousands of years in the form of opium for relief of pain or fever and to induce sleep. However, it wa..
Evolution of a student model building program designed to assist understanding of Biological Control Systems
DA WEAVER-COWDROY, RE KEMM, T GILDING, T PETROVIC, PJ HARRIS, LM DELBRIDGE
Conference Proceedings | 2001 | Proceedings of Ed-Media 2001 World Conference on Educational Multimedia, Hypermedia & Telecommunications
Stimulus interval-dependent differences in Ca2 transients and contractile responses of diabetic rat cardiomyocytes.
G Kotsanas, LM Delbridge, IR Wendt
Journal article | 2000 | Cardiovascular Research
OBJECTIVE: The aim of this study was to gain further insights into the consequences of insulin-dependent diabetes mellitus on card..
Cardiac hypertrophy depends upon sleep blood pressure: a study in rats.
TO Morgan, HR Brunner, JF Aubert, Q Wang, C Griffiths, L Delbridge
Journal article | 2000 | Journal of Hypertension
OBJECTIVE: The objective of this study was to determine whether cardiac hypertrophy in hypertensive rats could be reduced and norm..
Cardiodepressant effects of interferon-gamma and endotoxin reversed by inhibition of NO synthase 2 in rat myocardium.
X Sun, LM Delbridge, GJ Dusting
Journal article | 1998 | Journal of Molecular and Cellular Cardiology
Endogenous nitric oxide (NO) signalling pathways within the myocardium depress myocardial contractile function in septic shock and..
Cardiac myocyte volume, Ca2 fluxes, and sarcoplasmic reticulum loading in pressure-overload hypertrophy.
LM Delbridge, H Satoh, W Yuan, JW Bassani, M Qi, KS Ginsburg, AM Samarel, DM Bers
Journal article | 1997 | American Journal of Physiology-Heart and Circulatory Physiology
Alterations in cellular Ca2+ transport and excitation-contraction coupling may contribute to dysfunction in cardiac hypertrophy. L..
Optical methods to evaluate the contractile function of unloaded isolated cardiac myocytes.
LM Delbridge, KP Roos
Journal article | 1997 | Journal of Molecular and Cellular Cardiology
The enzymatically isolated cardiac myocyte has achieved prominence as an experimental model of myocardial excitation contraction c..
Contractile function of cardiomyocytes from the spontaneously hypertensive rat.
LM Delbridge, PJ Connell, TO Morgan, PJ Harris
Journal article | 1996 | Journal of Molecular and Cellular Cardiology
In essential hypertension it has been hypothesized that there is a generalized derangement in cellular Ca2+ homeostasis. The aim o..
Surface:volume relationship in cardiac myocytes studied with confocal microscopy and membrane capacitance measurements: species-dependence and developmental effects.
H Satoh, LM Delbridge, LA Blatter, DM Bers
Journal article | 1996 | Biophysical Journal
The quantitative analysis of the contribution of ion fluxes through membrane channels to changes of intracellular ion concentratio..
Steady-state twitch Ca2 fluxes and cytosolic Ca2 buffering in rabbit ventricular myocytes.
LM Delbridge, JW Bassani, DM Bers
Journal article | 1996 | American Journal of Physiology-Cell Physiology
Intracellular Ca2+ ([Ca2+]i) transients and transsarcolemmal Ca2+ currents were measured in indo 1-loaded isolated rabbit ventricu..
Effects of endothelin-1 on the contractility of cardiomyocytes from the spontaneously hypertensive rat.
LM Delbridge, TO Morgan, PJ Harris
Journal article | 1995 | Clinical and Experimental Pharmacology and Physiology
1. Disturbances in cardiovascular responsiveness to endogenous endothelin-1 (ET-1) may play a significant role in the pathogenesis..
A superfusion bath for single-cell recording with high-precision optical depth control, temperature regulation, and rapid solution switching.
LM Delbridge, PJ Harris, JT Pringle, LJ Dally, TO Morgan
Journal article | 1990 | Pfl�gers Archiv European Journal of Physiology
A superfusion system for isolated cell recording, which uses a novel optical technique for feedback control of solution depth (+/-..
Characterization of single heart cell contractility by rapid imaging.
LM Delbridge, PJ Harris, TO Morgan
Journal article | 1989 | Clinical and Experimental Pharmacology and Physiology
1. A rapid imaging technique with temporal resolution of about 1 ms was employed to describe cell-length changes during the isoton..
Heterogeneity of the action potential in isolated rat ventricular myocytes and tissue.
T Watanabe, LM Delbridge, JO Bustamante, TF McDonald
Journal article | 1983 | Circulation Research
The objectives of this study were to measure action potential parameters in enzyme-dissociated, adult rat ventricular myocytes sti..
An ultrastructural investigation into the size dependency of contractility of isolated cardiac muscle.
LM Delbridge, DS Loiselle
Journal article | 1981 | Cardiovascular Research
The maximal stress (force per cross-sectional area), maximal rate of stress development, and cross-sectional area of 30 rabbit rig..
Honours, Awards and Fellowships
Fellow of the National Heart Foundation of Australia
Fellow of the American Heart Association
American Physiological Society [APS]
High Blood Pressure Research Council Member
High Blood Pressure Research Council
Biophysical Society Member
Biophysical Society (USA)
Australian Physiological Society [AuPS, formerly APPS]
International Society for Heart Research [ISHR]
Doctor of Philosophy
University of Melbourne
Graduate Diploma in Education
University of Melbourne