David Greening

Quantitative proteomic landscape of unstable atherosclerosis identifies molecular signatures and therapeutic targets for plaque stabilization.

Yung-Chih Chen, Meaghan Smith, Ya-Lan Ying, Manousos Makridakis, Jonathan Noonan, Peter Kanellakis, Alin Rai, Agus Salim, Andrew Murphy, Alex Bobik, Antonia Vlahou, David W Greening, Karlheinz Peter

Journal article  |  2023  |  Commun Biol

Atherosclerotic plaque rupture leading to myocardial infarction is a major global health burden. Applying the tandem stenosis (TS)..

Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice

Yow Keat Tham, Bianca C Bernardo, Bethany Claridge, Gunes S Yildiz, Liesel Min-Linn Woon, Simon Bond, Haoyun Fang, Jenny YY Ooi, Aya Matsumoto, Jieting Luo, Celeste MK Tai, Claudia A Harmawan, Helen Kiriazis, Daniel G Donner, Natalie A Mellett, E Dale Abel, Sohaib A Khan, David P De Souza, Sheik Nadeem Elahee Doomun, Kevin Liu, et al.

Journal article  |  2023  |  Nature Cardiovascular Research

The mechanism of Pseudomonas aeruginosa outer membrane vesicle biogenesis determines their protein composition.

Lauren Zavan, Haoyun Fang, Ella L Johnston, Cynthia Whitchurch, David Greening, Andrew F Hill, Maria KaparakisLiaskos

Journal article  |  2023  |  Proteomics

Gram-negative bacteria produce outer membrane vesicles (OMVs) and contain bacterial cargo including nucleic acids and proteins. Th..

Extracellular vesicles as next generation immunotherapeutics.

David W Greening, Rong Xu, Anukreity Ale, Christoph E Hagemeyer, Weisan Chen

Journal article  |  2023  |  Semin Cancer Biol

Extracellular vesicles (EVs) function as a mode of intercellular communication and molecular transfer to elicit diverse biological..

Defining cardiac fibrosis complexity and regulation towards therapeutic development

Bethany Claridge, Auriane Drack, Alexander R Pinto, David W Greening

Journal article  |  2023  |  Clinical and Translational Discovery

Omics insights into extracellular vesicles in embryo implantation and their therapeutic utility

Qi Hui Poh, Alin Rai, Lois A Salamonsen, David W Greening

Journal article  |  2023  |  PROTEOMICS

Implantation success relies on intricate interplay between the developing embryo and the maternal endometrium. Extracellular vesic..

PS-BPB02-3: TARGETING FORMYL PEPTIDE RECEPTORS AS A NOVEL APPROACH TO TREAT HYPERTENSION-INDUCED ADVERSE CARDIOVASCULAR REMODELLING AND DYSFUNCTION

Jaideep Singh, Kristy L Jackson, Audrey Gumanti, Haoyun Fang, Owen L Woodman, Rebecca H Ritchie, David Greening, Geoffrey A Head, Chengxue Qin

Journal article  |  2023  |  Journal of Hypertension

Generation of Red Blood Cell Nanovesicles as a Delivery Tool.

Auriane Drack, Alin Rai, David W Greening

Journal article  |  2023  |  Methods Mol Biol

Extracellular vesicles (EVs) are natural membranous vesicles with immense potential as drug delivery tools. However, their large-s..

An Optimized Data-Independent Acquisition Strategy for Comprehensive Analysis of Human Plasma Proteome.

Haoyun Fang, David W Greening

Journal article  |  2023  |  Methods Mol Biol

Cartography of the plasma proteome remains technically challenging, primarily due to the abundance and dynamic range of plasma pro..

Preparation of Cryoprecipitate and Cryo-depleted Plasma for Proteomic Research Analysis.

Rosemary L Sparrow, Richard J Simpson, David W Greening

Journal article  |  2023  |  Methods Mol Biol

When frozen plasma is slowly thawed in cold conditions (1-6 °C), high-molecular-weight plasma proteins precipitate forming a conce..