Leann Tilley

Non-canonical metabolic pathways in the malaria parasite detected by isotope-tracing metabolomics.

Simon A Cobbold, Madel V Tutor, Philip Frasse, Emma McHugh, Markus Karnthaler, Darren J Creek, Audrey Odom John, Leann Tilley, Stuart A Ralph, Malcolm J McConville

Journal article  |  2021  |  Molecular Systems Biology

The malaria parasite, Plasmodium falciparum, proliferates rapidly in human erythrocytes by actively scavenging multiple carbon sou..

Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity.

Tatyana Almeida Tavella, Noeli Soares Melo da Silva, Natalie Spillman, Ana Carolina Andrade Vitor Kayano, Gustavo Capatti Cassiano, Adrielle Ayumi Vasconcelos, Antônio Pedro Camargo, Djane Clarys Baia da Silva, Diana Fontinha, Luis Carlos Salazar Alvarez, Letícia Tiburcio Ferreira, Kaira Cristina Peralis Tomaz, Bruno Junior Neves, Ludimila Dias Almeida, Daniel Youssef Bargieri, Marcus Vinicius Guimarães de Lacerda, Pedro Vitor Lemos Cravo, Per Sunnerhagen, Miguel Prudêncio, Carolina Horta Andrade, et al.

Journal article  |  2021  |  ACS Infectious Diseases

Antimalarial drugs with novel modes of action and wide therapeutic potential are needed to pave the way for malaria eradication. V..

Biochemical and cellular characterisation of the Plasmodium falciparum M1 alanyl aminopeptidase (PfM1AAP) and M17 leucyl aminopeptidase (PfM17LAP)

Rency Mathew, Juliane Wunderlich, Karine Thivierge, Krystyna Cwiklinski, Claire Dumont, Leann Tilley, Petra Rohrbach, John P Dalton

Journal article  |  2021  |  Scientific Reports

The Plasmodium falciparum M1 alanyl aminopeptidase and M17 leucyl aminopeptidase, PfM1AAP and PfM17LAP, are potential targets for ..

Surface Area-to-Volume Ratio, not Cellular Viscoelasticity is the Major Determinant of Red Blood Cell Traversal through Small Channels

Arman Namvar, Adam Blanch, Matthew Dixon, Olivia Carmo, Boyin Liu, Snigdha Tiash, Oliver Looker, Dean Andrew, Li-Jin Chan, Wai-Hong Tham, Peter VS Lee, Vijay Rajagopal, Leann Tilley

Journal article  |  2021  |  Biophysical Journal

Surface area-to-volume ratio, not cellular viscoelasticity, is the major determinant of red blood cell traversal through small channels.

Arman Namvar, Adam J Blanch, Matthew W Dixon, Olivia MS Carmo, Boyin Liu, Snigdha Tiash, Oliver Looker, Dean Andrew, Li-Jin Chan, Wai-Hong Tham, Peter VS Lee, Vijay Rajagopal, Leann Tilley

Journal article  |  2020  |  Cellular Microbiology

The remarkable deformability of red blood cells (RBCs) depends on the viscoelasticity of the plasma membrane and cell contents and..

K13, the Cytostome, and Artemisinin Resistance

Stanley C Xie, Stuart A Ralph, Leann Tilley

Journal article  |  2020  |  Trends in Parasitology

Artemisinins - the frontline antimalarial drug class - are compromised by emerging resistance, putting at risk the lives of hundre..

Trends Talk MAM 2020: Growing Strong on the 20th Anniversary

Alexis Kaushansky, Carol Sibley, Geoff McFadden, Susan Charman, Denise Doolan, Michael Good, Erika Flannery, Julie Healer, Michael Duffy, Terrie Taylor, Alister Craig, Leann Tilley, Paul Gilson

Journal article  |  2020  |  Trends in Parasitology

Role of Plasmodium falciparum Protein GEXPO7 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking

Emma McHugh, Olivia MS Carmo, Adam Blanch, Oliver Looker, Boyin Liu, Snigdha Tiash, Dean Andrew, Steven Batinovic, Andy JY Low, Hyun-Jung Cho, Paul McMillan, Leann Tilley, Matthew WA Dixon

Journal article  |  2020  |  MBIO

The malaria parasite Plasmodium falciparum traffics the virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) to..

Malaria parasites fine-tune mutations to resist drugs

Leann Tilley, Philip J Rosenthal

Journal article  |  2019  |  Nature

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

Tuo Yang, Lee M Yeoh, Madel V Tutor, Matthew W Dixon, Paul J McMillan, Stanley C Xie, Jessica L Bridgford, David L Gillett, Michael F Duffy, Stuart A Ralph, Malcolm J McConville, Leann Tilley, Simon A Cobbold

Journal article  |  2019  |  Cell Reports