Leann Tilley is Professor of Biochemistry and Molecular Biology, working in the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne. She is an Australian Research Council Georgina Sweet Australian Laureate Fellow.
Professor Tilley’s group undertakes research in the areas of cell biology and drug development related to the malaria parasite, Plasmodium falciparum. Her lab investigates the mechanisms of action of and resistance to the antimalarial drug, artemisinin, and is working to target proteostasis for the development of new antimalarial drugs. She is interested in the unusual protein trafficking pathways that the malaria parasite uses to display virulence proteins at the erythrocyte surface, and in understanding the molecular basis for the remarkable transformation that allows the malaria parasite to be transmitted from a human host to a mosquito vector.
Leann obtained her BSc(Hons) in Biochemistry from the University of Melbourne working with Bill Sawyer, and her PhD in Biochemistry from the University of Sydney, supervised by Greg Ralston. After postdoctoral fellowships at Utrecht University in the Netherlands, the College de France in Paris, and at the University of Melbourne, she joined the Biochemistry Department at La Trobe University. She was awarded an ARC Australian Professorial Fellowship. In the middle of 2011 she joined the Department of Biochemistry and Molecular Biology at the University of Melbourne.
Leann is a scientist who embraces a large range of technologies to further her understanding of her chosen biological questions, from drug and protein chemistry, to molecular cell biology, to novel imaging technologies. She is assisted in this by fantastic collaborations with experts from other disciplines, ranging from molecular parasitologists to organic chemists and optical physicists.
She served as Director of the ARC Centre of Excellence for Coherent X-ray Science (CXS) (2013-2014), which brought together physicists, chemists and biologists together to develop fundamentally new approaches to probing biological structures and processes. CXS received international acclaim for its cross-disciplinary and cross-institution work and for its contributions to the development of novel imaging techniques. As part of this collaboration Leann’s laboratory has helped to develop and implement a number of new imaging modalities and to apply them in pioneering applications. These include Coherent X-ray Diffraction Imaging, 3D Electron Tomography, Cryo-Xray Tomography, CryoEM and Structured Illumination Microscopy. She believes that answering the major medical and biotechnology questions of the 21st century will require a convergence of the Life and Physical sciences and will be heavily reliant on the use of advanced imaging techniques. She would like to be part of the exciting developments in this area.
For a Google Scholar analysis of Leann Tilley - see [https://scholar.google.com.au/citations?user=Z3U-exsAAAAJ&hl=en]
Lab Web Page: [http://biomedicalsciences.unimelb.edu.au/visit/tilley-lab]
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Leann Tilley's highlights
FEATURED Journal article
The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis
Read moreLeann Tilley's selected work
Nucleoside sulphamates as novel antimalarials for the treatment of Plasmodium falciparum
Research Grant
Using chemotherapy to fight malaria
NEWS ARTICLE
Erythrocyte beta spectrin can be genetically targeted to protect mice from malaria
Journal article
PROTEASOME INHIBITORS AS NEW POTENT RESISTANCE-REVERSING ANTIMALARIALS
Research Grant
Women in research rewarded for taking a risk
NEWS ARTICLE
Soft X-ray microscopy analysis of cell volume and hemoglobin content in erythrocytes infec..
Journal article
Leann Tilley's selected work
Projects
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Project Types
31
Research Grant
4
Internal Research Grant
1
Research Contracts
Additional Information
Professor Tilley's work is supported by grants from the National Health and Medical Research Council, the Australian Research Council, the Global Health Innovation Technology fund, and the GSK Tres Cantos Open Lab Foundation.
Scholarly Works
Displaying the 10 most recent scholarly works by Leann Tilley.
News
Displaying the 3 most recent news articles by Leann Tilley.
Honours, Awards and Fellowships
Credentials
Positions
Positions
Chair Of Biochemistry And Molecular Biology
Biochemistry And Molecular Biology
Council Member
Australian Society for Parasitology
Member
Australian Society for Biophysics
Lifetime Member
Lorne Conference on Protein Structure and Function
Previous President
Australian Society for Biochemistry and Molecular Biology
Education
Education
Doctor of Philosophy
University of Sydney
Bachelor of Science with Honours
University of Melbourne