Leann Tilley

Plasmodium falciparum goes bananas for sex

Matthew WA Dixon, Leann Tilley

Journal article  |  2021  |  MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The sexual blood stages of the human malaria parasite Plasmodium falciparum undergo a remarkable transformation from a roughly sph..

High Throughput Screening to Identify Selective and Nonpeptidomimetic Proteasome Inhibitors As Antimalarials

Lydia Mata-Cantero, Stanley C Xie, Mercedes Garcia, Joanne Coyle, Raquel Fernandez, Alvaro Cortes Cabrera, David L Gillett, Benigno Crespo, Francisco-Javier Gamo, Esther Fernandez, Leann Tilley, Maria G Gomez-Lorenzo

Journal article  |  2021  |  ACS INFECTIOUS DISEASES

The Ubiquitin Proteasome System is the main proteolytic pathway in eukaryotic cells, playing a role in key cellular processes. The..

Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity

Tatyana Almeida Tavella, Noeli Soares Melo da Silva, Natalie Spillman, Ana Carolina Andrade Vitor Kayano, Gustavo Capatti Cassiano, Adrielle Ayumi Vasconcelos, Antonio Pedro Camargo, Djane Clarys Baia da Silva, Diana Fontinha, Luis Carlos Salazar Alvarez, Leticia Tiburcio Ferreira, Kaira Cristina Peralis Tomaz, Bruno Junior Neves, Ludimila Dias Almeida, Daniel Youssef Bargieri, Marcus Vinicius Guimaraes de Lacerda, Pedro Vitor Lemos Cravo, Per Sunnerhagen, Miguel Prudencio, Carolina Horta Andrade, et al.

Journal article  |  2021  |  ACS INFECTIOUS DISEASES

Antimalarial drugs with novel modes of action and wide therapeutic potential are needed to pave the way for malaria eradication. V..

Non-canonical metabolic pathways in the malaria parasite detected by isotope-tracing metabolomics

Simon A Cobbold, Madel Tutor, Philip Frasse, Emma McHugh, Markus Karnthaler, Darren J Creek, Audrey Odom John, Leann Tilley, Stuart A Ralph, Malcolm J McConville

Journal article  |  2021  |  MOLECULAR SYSTEMS BIOLOGY

The malaria parasite, Plasmodium falciparum, proliferates rapidly in human erythrocytes by actively scavenging multiple carbon sou..

Surface Area-to-Volume Ratio, not Cellular Viscoelasticity is the Major Determinant of Red Blood Cell Traversal through Small Channels

Arman Namvar, Adam Blanch, Matthew Dixon, Olivia Carmo, Boyin Liu, Snigdha Tiash, Oliver Looker, Dean Andrew, Li-Jin Chan, Wai-Hong Tham, Peter VS Lee, Vijay Rajagopat, Leann Tilley

Journal article  |  2021  |  BIOPHYSICAL JOURNAL

Biochemical and cellular characterisation of the Plasmodium falciparum M1 alanyl aminopeptidase (PfM1AAP) and M17 leucyl aminopeptidase (PfM17LAP)

Rency Mathew, Juliane Wunderlich, Karine Thivierge, Krystyna Cwiklinski, Claire Dumont, Leann Tilley, Petra Rohrbach, John P Dalton

Journal article  |  2021  |  SCIENTIFIC REPORTS

The Plasmodium falciparum M1 alanyl aminopeptidase and M17 leucyl aminopeptidase, PfM1AAP and PfM17LAP, are potential targets for ..

Pfcerli2, a duplicated gene in the malaria parasite Plasmodium falciparum essential for invasion of erythrocytes as revealed by phylogenetic and cell biological analysis

Benjamin Liffner, Juan Miguel Balbin, Gerald Shami, Jan Strauss, Sonja Frölich, Gary Heinemann, Arne Alder, Jan Stephan Wichers, Leann Tilley, Matthew Dixon, Tim-Wolf Gilberger, Danny Wilson

Journal article  |  2020

ABSTRACT Merozoite invasion of host red blood cells (RBCs) is essential for survival of the human malaria parasite Plasmodium falc..

Surface area-to-volume ratio, not cellular viscoelasticity, is the major determinant of red blood cell traversal through small channels.

Arman Namvar, Adam J Blanch, Matthew W Dixon, Olivia MS Carmo, Boyin Liu, Snigdha Tiash, Oliver Looker, Dean Andrew, Li-Jin Chan, Wai-Hong Tham, Peter VS Lee, Vijay Rajagopal, Leann Tilley

Journal article  |  2020  |  Cellular Microbiology

The remarkable deformability of red blood cells (RBCs) depends on the viscoelasticity of the plasma membrane and cell contents and..

K13, the Cytostome, and Artemisinin Resistance

Stanley C Xie, Stuart A Ralph, Leann Tilley

Journal article  |  2020  |  TRENDS IN PARASITOLOGY

Artemisinins - the frontline antimalarial drug class - are compromised by emerging resistance, putting at risk the lives of hundre..

Trends Talk MAM 2020: Growing Strong on the 20th Anniversary

Alexis Kaushansky, Carol Sibley, Geoff McFadden, Susan Charman, Denise Doolan, Michael Good, Erika Flannery, Julie Healer, Michael Duffy, Terrie Taylor, Alister Craig, Leann Tilley, Paul Gilson

Journal article  |  2020  |  TRENDS IN PARASITOLOGY