Mark Hargreaves

Overview of Exercise Metabolism

Mark Hargreaves

Book Chapter  |  2022

Interactions between insulin and exercise

Erik A Richter, Lykke Sylow, Mark Hargreaves

Journal article  |  2021  |  BIOCHEMICAL JOURNAL

The interaction between insulin and exercise is an example of balancing and modifying the effects of two opposing metabolic regula..

Exercise and health: historical perspectives and new insights

Mark Hargreaves

Journal article  |  2021  |  JOURNAL OF APPLIED PHYSIOLOGY

Since ancient times, the health benefits of regular physical activity/exercise have been recognized and the classic studies of Mor..

Skeletal muscle energy metabolism during exercise

Mark Hargreaves, Lawrence L Spriet

Journal article  |  2020  |  NATURE METABOLISM

The continual supply of ATP to the fundamental cellular processes that underpin skeletal muscle contraction during exercise is ess..

Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit

Sean L McGee, Mark Hargreaves

Journal article  |  2020  |  NATURE REVIEWS ENDOCRINOLOGY

Exercise is fundamental for good health, whereas physical inactivity underpins many chronic diseases of modern society. It is well..

Exercise and GLUT4

Marcelo Flores-Opazo, Sean L McGee, Mark Hargreaves

Journal article  |  2020  |  EXERCISE AND SPORT SCIENCES REVIEWS

The glucose transporter GLUT4 is critical for skeletal muscle glucose uptake in response to insulin and muscle contraction/exercis..

Epigenetics and Exercise

Sean L McGee, Mark Hargreaves

Journal article  |  2019  |  TRENDS IN ENDOCRINOLOGY AND METABOLISM

Epigenetics can be defined as 'the structural adaptation of chromosomal regions so as to register, signal, or perpetuate altered a..

Exercise serum increases GLUT4 in human adipocytes

Marcelo Flores-Opazo, Arthe Raajendiran, Matthew J Watt, Mark Hargreaves

Journal article  |  2019  |  EXPERIMENTAL PHYSIOLOGY

NEW FINDINGS: What is the central question of this study? Do circulating factors mediate exercise-induced effects on adipose tissu..

Exercise and GLUT4 in human subcutaneous adipose tissue

Marcelo Flores-Opazo, Eva Boland, Andrew Garnham, Robyn M Murphy, Sean L McGee, Mark Hargreaves

Journal article  |  2018  |  PHYSIOLOGICAL REPORTS

To examine the effect of acute and chronic exercise on adipose tissue GLUT4 expression, a total of 20 healthy, male subjects perfo..

No evidence of direct association between GLUT4 and glycogen in human skeletal muscle

Robyn M Murphy, Marcelo Flores-Opazo, Barnaby P Frankish, Andrew Garnham, David Stapleton, Mark Hargreaves

Journal article  |  2018  |  PHYSIOLOGICAL REPORTS

Previous studies have demonstrated that exercise increases whole body and skeletal muscle insulin sensitivity that is linked with ..