William Louis

Function and expression of ATIP and its variants in cardiomyoblast cell line H9c2

Naghmeh Varghayee, Michael A Krezel, Linda Rezmann, Laurie Chow, Albert George Frauman, William J Louis, Simon N Louis

Journal article  |  2015  |  JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

HYPOTHESIS: Cardiac hypertrophy in myocytes is in part regulated by changes in expression of a novel Ang II type 2 receptor (AT2-r..

The Expression of MTUS1/ATIP and Its Major Isoforms, ATIP1 and ATIP3, in Human Prostate Cancer.

Simon NS Louis, Laurie TC Chow, Naghmeh Varghayee, Linda A Rezmann, Albert G Frauman, William J Louis

Journal article  |  2011  |  Cancers (Basel)

Angiotensin II (Ang II), the main effector of the renin angiotensin system, acts upon two distinct transmembrane receptors, the An..

Expression and Function of ATIP/MTUSI in Human Prostate Cancer Cell Lines

Simon NS Louis, Laurie Chow, Linda Rezmann, Michael A Krezel, Kevin J Catt, Chris Tikellis, Albert G Frauman, William J Louis

Journal article  |  2010  |  PROSTATE

BACKGROUND: We have previously demonstrated Ang II type 2 (AT(2)-) receptor-mediated inhibition of EGF-induced prostate cancer cel..

Role of the renin-angiotensin system in prostate cancer

L Chow, L Rezmann, KJ Catt, WJ Louis, AG Frauman, C Nahmias, SNS Louis

Journal article  |  2009  |  MOLECULAR AND CELLULAR ENDOCRINOLOGY

Prostate cancer is highly prevalent in Western society, and its early stages can be controlled by androgen ablation therapy. Howev..

Functional angiotensin II type 2 receptors inhibit growth factor signaling in LNCaP and PC3 prostate cancer cell lines

L Chow, L Rezmann, K Imamura, L Wang, K Catt, C Tikellis, WJ Louis, AG Fraurnan, SNS Louis

Journal article  |  2008  |  PROSTATE

BACKGROUND: There is clear evidence of a tissue-based renin-angiotensin system in the prostate and studies to date suggest that AT..

Appearance of angiotensin II expression in non-basal epithelial cells is an early feature of malignant change in human prostate

Simon N Louis, Lin Wang, Laurie Chow, Linda A Rezmann, Keisaku Imamura, Duncan P MacGregor, David Casely, Kevin J Catt, Albert G Frauman, William J Louis

Journal article  |  2007  |  CANCER DETECTION AND PREVENTION

BACKGROUND: Despite increasing interest in the renin-angiotensin system in cancer, little is known about angiotensin II (Ang II) e..

Role of Tyr356(7.43) and Ser190(4.57) in antagonist binding in the rat β1-adrenergic receptor

LA Rezmann-Vitti, TL Nero, GP Jackman, CA Machida, BJ Duke, WJ Louis, SNS Louis

Journal article  |  2006  |  Journal of Medicinal Chemistry

Site-directed mutagenesis and photoaffinity labeling experiments suggest the existence of at least two distinct binding orientatio..

Agonist binding and activation of the rat beta(1)-adrenergic receptor: role of Trp(134(3.28)), Ser(190(4.57)) and Tyr(356(7.43))

LA Rezmann-Vitti, SNS Louis, TL Nero, GP Jackman, D Iakovidis, CA Machida, WJ Louis

Journal article  |  2004  |  BIOCHEMICAL PHARMACOLOGY

We investigated the role of Trp(134(3.28)), Ser(190(4.57)) and Tyr(356(7.43)) in agonist binding to, and activation of, the rat be..

Site-directed mutagenesis of the rat beta(1)-adrenoceptor. Involvement of Tyr(356(7.43)) in ( /-)cyanopindolol but not ( /-)[(125)Iodo]cyanopindolol binding

LA Rezmann-Vitti, SNS Louis, TL Nero, GP Jackman, CA Machida, WJ Louis

Journal article  |  2004  |  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

To determine the role played by Tyr(356 (7.43)) in the rat beta(1)-adrenoceptor in binding the antagonists (+/-)cyanopindolol (4-[..

CoMFA analysis of the human beta(1)-adrenoceptor binding affinity of a series of phenoxypropanolamines

SN Louis, LA Rezmann-Vitti, TL Nero, D Iakovidis, GP Jackman, WJ Louis

Journal article  |  2002  |  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A series of 36 phenoxypropanolamines was examined to determine the structure--activity relationships of beta-adrenoceptor (beta-AR..