Thomas Martin

Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes

Emma C Walker, Kim Truong, Narelle E McGregor, Ingrid J Poulton, Tsuyoshi Isojima, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2020  |  eLife

Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, ..

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone (vol 10, 3436, 2019)

Christina Vrahnas, Martha Blank, Toby A Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwin, Nguyen Huynh, Mark R Forwood, Yifang Hu, Mika Ikegame, Keith R Bambery, Cyril Petibois, Eleanor J Mackie, Mark J Tobin, Gordon K Smyth, Jonathan S Oakhill, T John Martin, Natalie A Sims

Journal article  |  2019  |  Nature Communications

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism

Patricia WM Ho, Audrey S Chan, Nathan J Pavlos, Natalie A Sims, T John Martin

Journal article  |  2019  |  Biochemical Pharmacology

Parathyroid hormone (PTH)-related protein (PTHrP) (gene name Pthlh) was discovered as the factor responsible for the humoral hyper..

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

Christina Vrahnas, Martha Blank, Toby A Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwinl, Nguyen Huynh, Mark R Forwood, Yifang Hu, Mika Ikegame, Keith R Bambery, Cyril Petibois, Eleanor J Mackie, Mark J Tobin, Gordon K Smyth, Jonathan S Oakhill, T John Martin, Natalie A Sims

Journal article  |  2019  |  Nature Communications

Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralizatio..

Multiple actions of parathyroid hormone-related protein in breast cancer bone metastasis

T John Martin, Rachelle W Johnson

Journal article  |  2019  |  British Journal of Pharmacology

Meeting report from the 3rd IFMRS/KU Leuven Herbert Fleisch Workshop, Brugge, Belgium, 17-19 March 2019

Christa Maes, Roger Bouillon, T John Martin

Journal article  |  2019  |  Bone

IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis

Narelle E McGregor, Melissa Murat, Jeevithan Elango, Ingrid J Poulton, Emma C Walker, Blessing Crimeen-Irwin, Patricia WM Ho, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2019  |  Journal of Biological Chemistry

Antiresorptive and anabolic agents in the prevention and reversal of bone fragility

Ego Seeman, TJ Martin

Journal article  |  2019  |  Nature Reviews Rheumatology

Coupling of bone formation and resorption

NA Sims, TJ Martin

Book Chapter  |  2019

Paracrine parathyroid hormone-related protein in bone: Physiology and pharmacology

TJ Martin, NA Sims

Book Chapter  |  2019

Principles of bone biology

JP Bilezikian, TL Clemens, TJ Martin, CJ Rosen

Book  |  2019

Preface to the fourth edition

JP Bilezikian, TJ Martin, TL Clemens, CJ Rosen

Book  |  2019

The osteoblast lineage: Its actions and communication mechanisms

NA Sims, TJ Martin

Book Chapter  |  2019

Retinoic Acid Receptor gamma Activity in Mesenchymal Stem Cells Regulates Endochondral Bone, Angiogenesis, and B Lymphopoiesis

Alanna C Green, Victoria Rudolph-Stringer, Lenny Straszkowski, Gavin Tjin, Blessing Crimeen-Irwin, Mannu Walia, T John Martin, Natalie A Sims, Louise E Purton

Journal article  |  2018  |  Journal of Bone and Mineral Research

The C-terminal domain of PTHrP limits PTH receptor-mediated changes in gene expression in osteocytes

Yao Sun, Patricia WM Ho, Rachelle W Johnson, T John Martin, Natalie A Sims

Conference Proceedings  |  2018  |  JOURNAL OF BONE AND MINERAL RESEARCH

Bone corticalisation requires suppression of glycoprotein 130 signalling in osteocytes, and occurs by region-specific imbalances in bone formation and resorption

Emma Walker, Kim Truong, Narelle Mcgregor, T John Martin, Natalie A Sims

Conference Proceedings  |  2018  |  JOURNAL OF BONE AND MINERAL RESEARCH

Bone strength and mineralization are regulated independently of bone mass by ephrinB2-dependent autophagic processes in osteocytes

Vrahnas Christina, Toby Dite, Yifang Hu, Nguyen Huynh, Mark R Forwood, Keith R Bambery, Mark J Tobin, Gordon K Smyth, T John Martin, Natalie A Sims

Conference Proceedings  |  2018  |  JOURNAL OF BONE AND MINERAL RESEARCH

Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53

Mannu K Walia, Scott Taylor, Patricia WM Ho, T John Martin, Carl R Walkley

Journal article  |  2018  |  Cell Death & Disease

Murine models of osteosarcoma: A piece of the translational puzzle

Mannu K Walia, Wilson Castillo-Tandazo, Anthony J Mutsaers, Thomas John Martin, Carl R Walkley

Journal article  |  2018  |  Journal of Cellular Biochemistry

Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner

Rachelle W Johnson, Yao Sun, Patricia WM Ho, Audrey SM Chan, Jasmine A Johnson, Nathan J Pavlos, Natalie A Sims, T John Martin

Journal article  |  2018  |  FRONTIERS IN ENDOCRINOLOGY

Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein

Niloufar Ansari, Patricia WM Ho, Blessing Crimeen-Irwin, Ingrid J Poulton, Athena R Brunt, Mark R Forwood, Paola Divieti Pajevic, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2018  |  Journal of Bone and Mineral Research

Parathyroid hormone-related protein

JJ Wysolmerski, TJ Martin

Book Chapter  |  2018

Jeffrey Lima Hayes O'Riordan: March 27, 1931-October 9, 2017

T John Martin, Thomas L Clemens, Juliet E Compston, John T Potts, Rajesh V Thakker

Journal article  |  2018  |  Journal of Bone and Mineral Research

Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6

Dae-Chul Cho, Holly J Brennan, Rachelle W Johnson, Ingrid J Poulton, Jonathan H Gooi, Brett A Tonkin, Narelle E McGregor, Emma C Walker, David J Handelsman, TJ Martin, Natalie A Sims

Journal article  |  2017  |  NATURE COMMUNICATIONS

Reflecting on Some Discoveries of 40 Years and Their Outcomes

T John Martin

Journal article  |  2017  |  Journal of Bone and Mineral Research

Retinoic acid receptor signalling directly regulates osteoblast and adipocyte differentiation from mesenchymal progenitor cells

AC Green, P Kocovski, T Jovic, MK Walia, RAS Chandraratna, TJ Martin, EK Baker, LE Purton

Journal article  |  2017  |  Experimental Cell Research

Abaloparatide Is an Anabolic, but Does It Spare Resorption?

T John Martin, Ego Seeman

Journal article  |  2017  |  Journal of Bone and Mineral Research

Anabolic action of parathyroid hormone (PTH) does not compromise bone matrix mineral composition or maturation

Christina Vrahnas, Thomas A Pearson, Athena R Brunt, Mark R Forwood, Keith R Bambery, Mark J Tobin, T John Martin, Natalie A Sims

Journal article  |  2016  |  Bone

Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death

S Bhattacharya, AM Chalk, AJM Ng, TJ Martin, AC Zannettino, LE Purton, J Lu, EK Baker, CR Walkley

Journal article  |  2016  |  Oncogene

PARATHYROID HORMONE-RELATED PROTEIN, ITS REGULATION OF CARTILAGE AND BONE DEVELOPMENT, AND ROLE IN TREATING BONE DISEASES

T John Martin

Journal article  |  2016  |  Physiological Reviews

Bone metastasis: the importance of the neighbourhood

Peter I Croucher, Michelle M McDonald, T John Martin

Journal article  |  2016  |  Nature Reviews Cancer

Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance

Mannu K Walia, Patricia MW Ho, Scott Taylor, Alvin JM Ng, Ankita Gupte, Alistair M Chalk, Andrew CW Zannettino, T John Martin, Carl R Walkely

Journal article  |  2016  |  eLife

Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification

Stephen Tonna, Ingrid J Poulton, Farzin Taykar, Patricia WM Ho, Brett Tonkin, Blessing Crimeen-Irwin, Liliana Tatarczuch, Narelle E McGregor, Eleanor J Mackie, T John Martin, Natalie A Sims

Journal article  |  2016  |  Development

The role of vitamin A and retinoic acid receptor signaling in post-natal maintenance of bone

Alanna C Green, T John Martin, Louise E Purton

Journal article  |  2016  |  The Journal of Steroid Biochemistry and Molecular Biology

Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone

Rachelle W Johnson, Narelle E McGregor, Holly J Brennan, Blessing Crimeen-Irwin, Ingrid J Poulton, T John Martin, Natalie A Sims

Journal article  |  2015  |  Bone

Comment on: Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Non-Canonical cAMP/PKA Pathways

T John Martin

Journal article  |  2015  |  Journal of Bone and Mineral Research

RAR gamma is a negative regulator of osteoclastogenesis

Alanna C Green, Ingrid J Poulton, Christina Vrahnas, Karl D Haeusler, Carl R Walkley, Joy Y Wu, T John Martin, Matthew T Gillespie, Roshantha AS Chandraratna, Julian MW Quinn, Natalie A Sims, Louise E Purton

Journal article  |  2015  |  The Journal of Steroid Biochemistry and Molecular Biology

RANKL/OPG; Critical role in bone physiology

T John Martin, Natalie A Sims

Journal article  |  2015  |  Reviews in Endocrine and Metabolic Disorders

Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo

PWM Ho, A Goradia, MR Russell, AM Chalk, KM Milley, EK Baker, JA Danks, JL Slavin, M Walia, B Crimeen-Irwin, RA Dickins, TJ Martin, CR Walkley

Journal article  |  2015  |  Oncogene

Tribute To Stephen M Krane

Jean-Michel Dayer, Mary B Goldring, Steven R Goldring, Henry M Kronenberg, T John Martin, R Graham G Russell

Journal article  |  2015  |  Journal of Bone and Mineral Research

Co-administration of Antiresorptive and Anabolic Agents: A Missed Opportunity

Ego Seeman, T John Martin

Journal article  |  2015  |  Journal of Bone and Mineral Research

The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation

Alvin JM Ng, Mannu K Walia, Monique F Smeets, Anthony J Mutsaers, Natalie A Sims, Louise E Purton, Nicole C Walsh, T John Martin, Carl R Walkley

Journal article  |  2015  |  PLOS GENETICS

Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma

Emma K Baker, Scott Taylor, Ankita Gupte, Alistair M Chalk, Shreya Bhattacharya, Alanna C Green, T John Martin, Dario Strbenac, Mark D Robinson, Louise E Purton, Carl R Walkley

Journal article  |  2015  |  Bone

Coupling signals between the osteoclast and osteoblast how are messages transmitted between these temporary visitors to the bone surface?

Natalie A Sims, T John Martin

Journal article  |  2015  |  FRONTIERS IN ENDOCRINOLOGY

Isolation and gene expression of haematopoietic-cell-free preparations of highly purified murine osteocytes

Ling Yeong Chia, Nicole C Walsh, T John Martin, Natalie A Sims

Journal article  |  2015  |  Bone

Calcitonin Physiology, Saved by a Lysophospholipid

T John Martin, Natalie A Sims

Journal article  |  2015  |  Journal of Bone and Mineral Research

PTHrP, its receptor, and protein kinase A activation in osteosarcoma.

Carl R Walkley, Mannu K Walia, Patricia W Ho, T John Martin

Journal article  |  2014  |  Molecular & Cellular Oncology

In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-depen..

EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis

Stephen Tonna, Farzin M Takyar, Christina Vrahnas, Blessing Crimeen-Irwin, Patricia WM Ho, Ingrid J Poulton, Holly J Brennan, Narelle E McGregor, Elizabeth H Allan, Huynh Nguyen, Mark R Forwood, Liliana Tatarczuch, Eleanor J Mackie, T John Martin, Natalie AZ Sims

Journal article  |  2014  |  The FASEB Journal

Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts

Benoit Le Goff, Sofie Singbrant, Brett A Tonkin, T John Martin, Evange Romas, Natalie A Sims, Nicole C Walsh

Journal article  |  2014  |  Cytokine

Myokines (muscle-derived cytokines and chemokines) including ciliary neurotrophic factor (CNTF) inhibit osteoblast differentiation

Rachelle W Johnson, Jason D White, Emma C Walker, T John Martin, Natalie A Sims

Journal article  |  2014  |  Bone

New therapeutics for osteoporosis

Kong Wah Ng, T John Martin

Journal article  |  2014  |  Current Opinion in Pharmacology

UThe Primary Function of gp130 Signaling in Osteoblasts Is To Maintain Bone Formation and Strength, Rather Than Promote Osteoclast Formation

Rachelle W Johnson, Holly J Brennan, Christina Vrahnas, Ingrid J Poulton, Narelle E McGregor, Therese Standal, Emma C Walker, Thuan-Tzen Koh, Huynh Nguyen, Nicole C Walsh, Mark R Forwood, T John Martin, Natalie A Sims

Journal article  |  2014  |  Journal of Bone and Mineral Research

Decline in calcitonin receptor expression in osteocytes with age

Jonathan H Gooi, Ling Yeong Chia, Nicole C Walsh, Morten A Karsdal, Julian MW Quinn, T John Martin, Natalie A Sims

Journal article  |  2014  |  JOURNAL OF ENDOCRINOLOGY

Bone biology and anabolic therapies for bone: current status and future prospects.

T John Martin

Journal article  |  2014  |  Journal of Bone Metabolism

Bone is continuously remodelled at many sites asynchronously throughout the skeleton, with bone formation and resorption balanced ..

Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit.

Natalie A Sims, T John Martin

Journal article  |  2014  |  BoneKEy Reports

Coupling between bone formation and bone resorption refers to the process within basic multicellular units in which resorption by ..

Future Therapies of Osteoporosis

KW Ng, T John Martin

Book Chapter  |  2013

Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA

Anthony J Mutsaers, Alvin JM Ng, Emma K Baker, Megan R Russell, Alistair M Chalk, Meaghan Wall, Brain JJ Liddicoat, Patricia WM Ho, John L Slavin, Ankita Goradia, T John Martin, Louise E Purton, Ross A Dickins, Carl R Walkley

Journal article  |  2013  |  BONE

EphrinB2/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone

Farzin M Takyar, Stephen Tonna, Patricia WM Ho, Blessing Crimeen-Irwin, Emma K Baker, T John Martin, Natalie A Sims

Journal article  |  2013  |  Journal of Bone and Mineral Research

Iain MacIntyre. 30 August 1924 — 18 September 2008

T John Martin

Journal article  |  2012  |  Biographical Memoirs of Fellows of the Royal Society

Twenty-five years of PTHrP progress: From cancer hormone to multifunctional cytokine

Laurie K McCauley, T John Martin

Journal article  |  2012  |  Journal of Bone and Mineral Research

Sustained RANKL Response to Parathyroid Hormone in Oncostatin M Receptor-Deficient Osteoblasts Converts Anabolic Treatment to a Catabolic Effect In Vivo

Emma C Walker, Ingrid J Poulton, Narelle E McGregor, Patricia WM Ho, Elizabeth H Allan, Julie M Quach, T John Martin, Natalie A Sims

Journal article  |  2012  |  Journal of Bone and Mineral Research

Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment

Sofie Singbrant, Megan R Russell, Tanja Jovic, Brian Liddicoat, David J Izon, Louise E Purton, Natalie A Sims, T John Martin, Vijay G Sankaran, Carl R Walkley

Journal article  |  2011  |  Blood

Zinc Finger Protein 467 Is a Novel Regulator of Osteoblast and Adipocyte Commitment

Julie M Quach, Emma C Walker, Elizabeth Allan, Melissa Solano, Atsushi Yokoyama, Shigeaki Kato, Natalie A Sims, Matthew T Gillespie, T John Martin

Journal article  |  2011  |  Journal of Biological Chemistry

Advances in the biology of bone metastasis: how the skeleton affects tumor behavior.

Julie A Sterling, James R Edwards, T John Martin, Gregory R Mundy

Journal article  |  2011  |  Bone

It is increasingly evident that the microenvironment of bone can influence the cancer phenotype in many ways that favor growth in ..

Severe developmental bone phenotype in ClC-7 deficient mice

AV Neutzsky-Wulff, NA Sims, C Supanchart, U Kornak, D Felsenberg, IJ Poulton, TJ Martin, MA Karsdal, K Henriksen

Journal article  |  2010  |  Developmental Biology

Control of mammary stem cell function by steroid hormone signalling

Marie-Liesse Asselin-Labat, Francois Vaillant, Julie M Sheridan, Bhupinder Pal, Di Wu, Evan R Simpson, Hisataka Yasuda, Gordon K Smyth, T John Martin, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2010  |  Nature

Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes

JH Gooi, S Pompolo, MA Karsdal, NH Kulkarni, I Kalajzic, SHM McAhren, B Han, JE Onyia, PWM Ho, MT Gillespie, NC Walsh, LY Chia, JMW Quinn, TJ Martin, NA Sims

Journal article  |  2010  |  BONE

Ciliary Neurotrophic Factor Inhibits Bone Formation and Plays a Sex-Specific Role in Bone Growth and Remodeling

Narelle E McGregor, Ingrid J Poulton, Emma C Walker, Sueli Pompolo, Julian MW Quinn, T John Martin, Natalie A Sims

Journal article  |  2010  |  Calcified Tissue International

Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice

Emma C Walker, Narelle E McGregor, Ingrid J Poulton, Melissa Solano, Sueli Pompolo, Tania J Fernandes, Matthew J Constable, Geoff C Nicholson, Jian-Guo Zhang, Nicos A Nicola, Matthew T Gillespie, John Martin, Natalie A Sims

Journal article  |  2010  |  Journal of Clinical Investigation

Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling

Peter Pivonka, Jan Zimak, David W Smith, Bruce S Gardiner, Colin R Dunstan, Natalie A Sims, T John Martin, Gregory R Mundy

Journal article  |  2010  |  Journal of Theoretical Biology

Communication Between EphrinB2 and EphB4 Within the Osteoblast Lineage

TJ Martin, EH Allan, PWM Ho, JH Gooi, JMW Quinn, MT Gillespie, V Krasnoperov, NA Sims

Journal article  |  2010  |  Advances in Experimental Medicine and Biology

The Chemokine Cxcl1 Is a Novel Target Gene of Parathyroid Hormone (PTH)/PTH-Related Protein in Committed Osteoblasts

Doene Onan, Elizabeth H Allan, Julian MW Quinn, Jonathan H Gooi, Sueli Pompolo, Natalie A Sims, Matthew T Gillespie, T John Martin

Journal article  |  2009  |  Endocrinology

Crystallization of the receptor-binding domain of parathyroid hormone-related protein in complex with a neutralizing monoclonal antibody Fab fragment

William J McKinstry, Galina Polekhina, Hannelore Diefenbach-Jagger, Koh Sato, Etsuro Onuma, Matthew T Gillespie, Thomas J Martin, Michael W Parker

Journal article  |  2009  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

Molecular Mechanisms in Coupling of Bone Formation to Resorption

T John Martin, Jonathan H Gooi, Natalie A Sims

Journal article  |  2009  |  Critical Reviews in Eukaryotic Gene Expression

The chemokine Cxcl1 is a novel target gene of PTH/PTHrP in committed osteoblasts

undefined Onan, EH Allan, JM Quinn, JH Gooi, undefined Pompolo, NA Sims, MT Gillespie, TJ Martin

Journal article  |  2009  |  Endocrinology

Cardiotrophin-1 Is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling

Emma C Walker, Narelle E McGregor, Ingrid J Poulton, Such Pompolo, Elizabeth H Allan, Julian MW Quinn, Matthew T Gillespie, T John Martin, Natalie A Sims

Journal article  |  2008  |  Journal of Bone and Mineral Research

Osteoclast Inhibitory Lectin, an Immune Cell Product That Is Required for Normal Bone Physiology in Vivo

Vicky Kartsogiannis, Natalie A Sims, Julian MW Quinn, Chi Ly, Mirijana Cipetic, Ingrid J Poulton, Emma C Walker, Hasnawati Saleh, Narelle E McGregor, Morgan E Wallace, Mark J Smyth, T John Martin, Hong Zhou, Kong Wah Ng, Matthew T Gillespie

Journal article  |  2008  |  Journal of Biological Chemistry

IL-23 inhibits osteoclastogenesis indirectly through lymphocytes and is required for the maintenance of bone mass in mice

Julian MW Quinn, Natalie A Sims, Hasnawati Saleh, Danijela Mirosa, Keith Thompson, Stelios Bouralexis, Emma C Walker, T John Martin, Matthew T Gillespie

Journal article  |  2008  |  Journal of Immunology

Bone remodelling: its local regulation and the emergence of bone fragility

T John Martin, Ego Seeman

Journal article  |  2008  |  Best Practice & Research: Clinical Endocrinology & Metabolism

EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts

Elizabeth H Allan, Karl D Hausler, Tao Wei, Jonathan H Gooi, Julian MW Quinn, Blessing Crimeen-Irwin, Sueli Pompolo, Natalie A Sims, Matthew T Gillespie, Jude E Onyia, T John Martin

Journal article  |  2008  |  Journal of Bone and Mineral Research

Regulatory pathways revealing new approaches to the development of anabolic drugs for osteoporosis

TJ Martin, NA Sims, KW Ng

Journal article  |  2008  |  Osteoporosis International

Model structure and control of bone remodeling: A theoretical study

Peter Pivonka, Jan Zimak, David W Smith, Bruce S Gardiner, Colin R Dunstan, Natalie A Sims, T John Martin, Gregory R Mundy

Journal article  |  2008  |  Bone

Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro

Akira Nakamura, Chi Ly, Mirijana Cipetic, Natalie A Sims, Jessica Vieusseux, Vicky Kartsogiannis, Stellos Bouralexis, Hasnawati Saleh, Hong Zhou, John T Price, I John Martin, Ko Wah Ng ng, Matthew T Gillespie, Julian MW Quinn

Journal article  |  2007  |  Bone

New mechanisms and targets in the treatment of bone fragility

T John Martin, Ego Seeman

Journal article  |  2007  |  Clinical Science

New agents for the treatment of osteoporosis

T MARTIN, K NG

Journal article  |  2007  |  Hearing Research

Protein nutrition as therapy for a genetic disorder of bone?

T John Martin

Journal article  |  2006  |  Cell Metabolism

Orally bioavailable GSK-3 alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo

Nalini H Kulkarni, Jude E Onyia, QingQiang Zeng, Xioayan Tian, Min Liu, David L Halladay, Charles A Frolik, Thomas Engler, Tao Wei, Aidas Kriauciunas, T John Martin, Masahiko Sato, Henry U Bryant, Yanfei L Ma

Journal article  |  2006  |  Journal of Bone and Mineral Research

Osteoprotegerin overexpression by breast cancer cells enhances orthotopic and osseous tumor growth and contrasts with that delivered therapeutically

JL Fisher, RJ Thomas-Mudge, J Elliott, DK Hards, NA Sims, J Slavin, TJ Martin, MT Gillespie

Journal article  |  2006  |  Cancer Research

Parathyroid hormone-related protein localization in breast cancers predict improved prognosis

MA Henderson, JA Danks, JL Slavin, GB Byrnes, PFM Choong, JB Spillane, JL Hopper, TJ Martin

Journal article  |  2006  |  Cancer Research

Mechanisms involved in skeletal anabolic therapies

TJ Martin, JMW Quinn, MT Gillespie, KW Ng, MA Karsdal, NA Sims

Journal article  |  2006  |  Annals of The New York Academy of Sciences

Parathyroid hormone-related protein production in the lamprey Geotria australis: developmental and evolutionary perspectives

MK Trivett, IC Potter, G Power, H Zhou, DL Macmillan, TJ Martin, JA Danks

Journal article  |  2005  |  Development Genes and Evolution

Effects of parathyroid hormone on Wnt signaling pathway in bone

NH Kulkarni, DL Halladay, RR Miles, LM Gilbert, CA Frolik, RJS Galvin, TJ Martin, MT Gillespie, JE Onyia

Journal article  |  2005  |  Journal of Cellular Biochemistry

Interleukin-11 receptor signaling is required for normal bone remodeling

NA Sims, BJ Jenkins, A Nakamura, JMW Quinn, RL Li, MT Gillespie, M Ernst, L Robb, TJ Martin

Journal article  |  2005  |  Journal of Bone and Mineral Research

Osteoclast-derived activity in the coupling of bone formation to resorption

TJ Martin, NA Sims

Journal article  |  2005  |  Trends in Molecular Medicine

Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation

KD Hausler, NJ Horwood, Y Chuman, JL Fisher, J Ellis, TJ Martin, JS Rubin, MT Gillespie

Journal article  |  2004  |  Journal of Bone and Mineral Research

Paracrine regulation of osteoclast formation and activity: milestones in discovery.

TJ Martin

Journal article  |  2004  |  Journal of Musculoskeletal Neuronal Interactions

The molecular and physiological mechanisms of control of osteoclast formation and activity have been explained with the discovery ..

Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis

NA Sims, JR Green, M Glatt, S Schlict, TJ Martin, MT Gillespie, E Romas

Journal article  |  2004  |  Arthritis and Rheumatism

Novel and selective small molecule stimulators of osteoprotegerin expression inhibit bone resorption

JE Onyia, RJS Galvin, YFL Ma, DL Halladay, RR Miles, XH Yang, T Fuson, RL Cain, QQ Zeng, S Chandrasekhar, R Emkey, YP Xu, K Thirunavukkarasu, HU Bryant, TJ Martin

Journal article  |  2004  |  Journal of Pharmacology and Experimental Therapeutics

Does bone resorption inhibition affect the anabolic response to parathyroid hormone?

TJ Martin

Journal article  |  2004  |  Trends in Endocrinology and Metabolism

Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signalling pathways

NA Sims, BJ Jenkins, JMW Quinn, A Nakamura, M Glatt, MT Gillespie, M Ernst, TJ Martin

Journal article  |  2004  |  Journal of Clinical Investigation

Differentiation potential of a mouse bone marrow stromal cell line

EH Allan, PWM Ho, A Umezawa, J Hata, F Makishima, MT Gillespie, TJ Martin

Journal article  |  2003  |  Journal of Cellular Biochemistry

Identification of a parathyroid hormone in the fish Fugu rubripes

JA Danks, PMW Ho, AJ Notini, F Katsis, P Hoffmann, BE Kemp, TJ Martin, JD Zajac

Journal article  |  2003  |  Journal of Bone and Mineral Research

T-cells mediate an inhibitory effect of interleukin-4 on osteoclastogenesis

D Mirosavljevic, JMW Quinn, J Elliott, NJ Horwood, TJ Martin, MT Gillespie

Journal article  |  2003  |  Journal of Bone and Mineral Research

Manipulating the environment of cancer cells in bone: a novel therapeutic approach

TJ Martin

Journal article  |  2002  |  Journal of Clinical Investigation

Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis

E Romas, NA Sims, DK Hards, M Lindsay, JWM Quinn, PFJ Ryan, CR Dunstan, TJ Martin, MT Gillespie

Journal article  |  2002  |  American Journal of Pathology

The COOH-terminus of parathyroid hormone-related protein (PTHrP) interacts with beta-arrestin 1B

LA Conlan, TJ Martin, MT Gillespie

Journal article  |  2002  |  FEBS Letters

Parathyroid hormone-related protein (PTHrP) production sites in elasmobranchs

MK Trivett, TI Walker, DL Macmillan, JG Clement, TJ Martin, JA Danks

Journal article  |  2002  |  Journal of Anatomy

Co-expression of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP receptor in cartilaginous tumours: a marker for malignancy?

T Kunisada, JM Moseley, JL Slavin, TJ Martin, PFM Choong

Journal article  |  2002  |  Pathology

Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules

MHC Lam, RJ Thomas, KL Loveland, S Schilders, M Gu, TJ Martin, MT Gillespie, DA Jans

Journal article  |  2002  |  Molecular Endocrinology

Involvement of receptor activator of NF kappa B ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis

E Romas, MT Gillespie, TJ Martin

Journal article  |  2002  |  Bone

Fetal parathyroids are not required to maintain placental calcium transport

CS Kovacs, NR Manley, JM Moseley, TJ Martin, HM Kronenberg

Journal article  |  2001  |  Journal of Clinical Investigation

Parathyroid hormone-related protein production by breast cancers, improved survival, and reduced bone metastases

MA Henderson, JA Danks, JM Moseley, JL Slavin, TL Harris, MR McKinlay, JL Hopper, TJ Martin

Journal article  |  2001  |  Journal of the National Cancer Institute