Thomas Martin

Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes

Emma C Walker, Kim Truong, Narelle E McGregor, Ingrid J Poulton, Tsuyoshi Isojima, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2020  |  eLife

Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, ..

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone (vol 10, 3436, 2019)

Christina Vrahnas, Martha Blank, Toby A Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwin, Nguyen Huynh, Mark R Forwood, Yifang Hu, Mika Ikegame, Keith R Bambery, Cyril Petibois, Eleanor J Mackie, Mark J Tobin, Gordon K Smyth, Jonathan S Oakhill, T John Martin, Natalie A Sims

Journal article  |  2019  |  Nature Communications

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism

Patricia WM Ho, Audrey S Chan, Nathan J Pavlos, Natalie A Sims, T John Martin

Journal article  |  2019  |  Biochemical Pharmacology

Parathyroid hormone (PTH)-related protein (PTHrP) (gene name Pthlh) was discovered as the factor responsible for the humoral hyper..

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

Christina Vrahnas, Martha Blank, Toby A Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwinl, Nguyen Huynh, Mark R Forwood, Yifang Hu, Mika Ikegame, Keith R Bambery, Cyril Petibois, Eleanor J Mackie, Mark J Tobin, Gordon K Smyth, Jonathan S Oakhill, T John Martin, Natalie A Sims

Journal article  |  2019  |  Nature Communications

Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralizatio..

Multiple actions of parathyroid hormone-related protein in breast cancer bone metastasis

T John Martin, Rachelle W Johnson

Journal article  |  2019  |  British Journal of Pharmacology

Meeting report from the 3rd IFMRS/KU Leuven Herbert Fleisch Workshop, Brugge, Belgium, 17-19 March 2019

Christa Maes, Roger Bouillon, T John Martin

Journal article  |  2019  |  Bone

IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis

Narelle E McGregor, Melissa Murat, Jeevithan Elango, Ingrid J Poulton, Emma C Walker, Blessing Crimeen-Irwin, Patricia WM Ho, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2019  |  Journal of Biological Chemistry

Antiresorptive and anabolic agents in the prevention and reversal of bone fragility

Ego Seeman, TJ Martin

Journal article  |  2019  |  Nature Reviews Rheumatology

Paracrine parathyroid hormone-related protein in bone: Physiology and pharmacology

TJ Martin, NA Sims

Book Chapter  |  2019

Coupling of bone formation and resorption

NA Sims, TJ Martin

Book Chapter  |  2019