Thomas Martin

Interaction between osteocyte SOCS3-dependent signaling and the bone marrow microenvironment maintains cortical bone integrity

Tsuyoshi Isojima, Emma C Walker, Blessing Crimeen-Irwin, Ingrid J Poulton, Narelle E McGregor, Jonathan H Gooi, T John Martin, Natalie A Sims

Conference Proceedings  |  2020  |  JOURNAL OF BONE AND MINERAL RESEARCH

Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes

Emma C Walker, Kim Truong, Narelle E McGregor, Ingrid J Poulton, Tsuyoshi Isojima, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2020  |  ELIFE

Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, ..

Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms

Natalie A Sims, T John Martin

Journal article  |  2020  |  ANNUAL REVIEW OF PHYSIOLOGY, VOL 82

Bone remodeling is essential for the repair and replacement of damaged and old bone. The major principle underlying this process i..

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone (vol 10, 3436, 2019)

Christina Vrahnas, Martha Blank, Toby A Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwin, Nguyen Huynh, Mark R Forwood, Yifang Hu, Mika Ikegame, Keith R Bambery, Cyril Petibois, Eleanor J Mackie, Mark J Tobin, Gordon K Smyth, Jonathan S Oakhill, T John Martin, Natalie A Sims

Journal article  |  2019  |  NATURE COMMUNICATIONS

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism

Patricia WM Ho, Audrey S Chan, Nathan J Pavlos, Natalie A Sims, T John Martin

Journal article  |  2019  |  BIOCHEMICAL PHARMACOLOGY

Parathyroid hormone (PTH)-related protein (PTHrP) (gene name Pthlh) was discovered as the factor responsible for the humoral hyper..

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

Christina Vrahnas, Martha Blank, Toby A Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwinl, Nguyen Huynh, Mark R Forwood, Yifang Hu, Mika Ikegame, Keith R Bambery, Cyril Petibois, Eleanor J Mackie, Mark J Tobin, Gordon K Smyth, Jonathan S Oakhill, T John Martin, Natalie A Sims

Journal article  |  2019  |  Nature Communications

Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralizatio..

Multiple actions of parathyroid hormone-related protein in breast cancer bone metastasis

T John Martin, Rachelle W Johnson

Journal article  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

The sequence similarity within the amino-terminal regions of parathyroid hormone (PTH) and PTH-related protein (PTHrP) allows the ..

Meeting report from the 3rd IFMRS/KU Leuven Herbert Fleisch Workshop, Brugge, Belgium, 17-19 March 2019

Christa Maes, Roger Bouillon, T John Martin

Journal article  |  2019  |  BONE

IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis

Narelle E McGregor, Melissa Murat, Jeevithan Elango, Ingrid J Poulton, Emma C Walker, Blessing Crimeen-Irwin, Patricia WM Ho, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2019  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin 6 (IL-6) supports development of bone-resorbing osteoclasts by acting early in the osteoblast lineage via membrane-bou..

Antiresorptive and anabolic agents in the prevention and reversal of bone fragility

Ego Seeman, TJ Martin

Journal article  |  2019  |  NATURE REVIEWS RHEUMATOLOGY

Bone volume, microstructure and its material composition are maintained by bone remodelling, a cellular activity carried out by bo..