P. Mark Hogarth

Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2 (vol 13, 889372, 2022)

Bruce D Wines, Liriye Kurtovic, Halina M Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L Mordant, Wen Shi Lee, Nicholas A Gherardin, Sheila K Patel, Gemma E Hartley, Phillip Pymm, James P Cooney, James G Beeson, Dale I Godfrey, Louise M Burrell, Menno C van Zelm, Adam K Wheatley, Amy WW Chung, et al.

Journal article  |  2023  |  FRONTIERS IN IMMUNOLOGY

[This corrects the article .].

The second COVID-19 mRNA vaccine dose enhances the capacity of Spike-specific memory B cells to bind Omicron BA.2

Gemma E Hartley, Emily SJ Edwards, Nirupama Varese, Irene Boo, Pei M Aui, Scott J Bornheimer, P Mark Hogarth, Heidi E Drummer, Robyn E O'Hehir, Menno C van Zelm

Journal article  |  2022  |  ALLERGY

Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques

Brendon Y Chua, Toshiki Sekiya, Marios Koutsakos, Naoki Nomura, Louise C Rowntree, Thi HO Nguyen, Hayley A McQuilten, Marumi Ohno, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Yasushi Itoh, Jennifer R Habel, Kevin J Selva, Adam K Wheatley, Bruce D Wines, P Mark Hogarth, Stephen J Kent, Amy W Chung, David C Jackson, et al.

Journal article  |  2022  |  PLOS PATHOGENS

Although antibody-inducing split virus vaccines (SV) are currently the most effective way to combat seasonal influenza, their effi..

RNA sequencing of single allergen-specific memory B cells after grass pollen immunotherapy: Two unique cell fates and CD29 as a biomarker for treatment effect

Craig McKenzie, Nirupama Varese, Pei Mun Aui, Simone Reinwald, Bruce D Wines, P Mark Hogarth, Francis Thien, Mark Hew, Jennifer M Rolland, Robyn E O'Hehir, Menno C van Zelm

Journal article  |  2022  |  ALLERGY

BACKGROUND: Sublingual immunotherapy (SLIT) for grass pollen allergy can modify the natural history of allergic rhinitis and is as..

Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children

Gaoqian Feng, Liriye Kurtovic, Paul A Agius, Elizabeth H Aitken, Jahit Sacarlal, Bruce D Wines, P Mark Hogarth, Stephen J Rogerson, Freya J Fowkes, Carlota Dobano, James G Beeson

Journal article  |  2022  |  BMC MEDICINE

BACKGROUND: RTS,S is the first malaria vaccine recommended for implementation among young children at risk. However, vaccine effic..

Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2

Bruce D Wines, Liriye Kurtovic, Halina M Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L Mordant, Wen Shi Lee, Nicholas A Gherardin, Sheila K Patel, Gemma E Hartley, Phillip Pymm, James P Cooney, James G Beeson, Dale Godfrey, Louise M Burrell, Menno C van Zelm, Adam K Wheatley, Amy W Chung, et al.

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor ACE2 produces an antiviral decoy with strain ..

Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children

Jo-Anne Chan, Jessica R Loughland, Lauren de la Parte, Satomi Okano, Isaac Ssewanyana, Mayimuna Nalubega, Felistas Nankya, Kenneth Musinguzi, John Rek, Emmanuel Arinaitwe, Peta Tipping, Peter Bourke, Dean Andrew, Nicholas Dooley, Arya SheelaNair, Bruce D Wines, P Mark Hogarth, James G Beeson, Bryan Greenhouse, Grant Dorsey, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

T-follicular helper (Tfh) cells are key drivers of antibodies that protect from malaria. However, little is known regarding the ho..

A Quantitative Approach to Unravel the Role of Host Genetics in IgG-Fc gamma R Complex Formation After Vaccination

Melissa M Lemke, Robert M Theisen, Emily R Bozich, Milla R McLean, Christina Y Lee, Ester Lopez, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Sven Kratochvil, Bruce D Wines, P Mark Hogarth, Stephen J Kent, Amy W Chung, Kelly B Arnold

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Fc-mediated immune functions have been correlated with protection in the RV144 HIV vaccine trial and are important for immunity to..

Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children.

Damian A Oyong, Jessica R Loughland, Megan SF Soon, Jo-Anne Chan, Dean Andrew, Bruce D Wines, P Mark Hogarth, Stuart D Olver, Alika D Collinge, Antiopi Varelias, James G Beeson, Enny Kenangalem, Ric N Price, Nicholas M Anstey, Gabriela Minigo, Michelle J Boyle

Journal article  |  2022  |  EBioMedicine

BACKGROUND: Protective malarial antibodies are acquired more rapidly in adults than children, independently of cumulative exposure..

Role of anti-HBs in functional cure of HBeAg plus chronic hepatitis B patients infected with HBV genotype A

Hui Xu, Stephen Locarnini, Darren Wong, Rachel Hammond, Danni Colledge, Sally Soppe, Thao Huynh, Tim Shaw, Alexander J Thompson, Peter A Revill, P Mark Hogarth, Bruce D Wines, Renae Walsh, Nadia Warner

Journal article  |  2021  |  JOURNAL OF HEPATOLOGY

BACKGROUND & AIMS: HBsAg-specific antibody responses are difficult to detect during chronic hepatitis B infection (CHB) and are of..