Prof Andrew Gundlach

Find out more about Andrew Gundlach's experience

Andrew Gundlach's highlights

FEATURED Journal article

RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via M-like Current Activation and Contributes to Binge Eating Behavior

Andrew Gundlach's selected work

A New Therapeutic Target For Stress-Related Relapse

Research Grant

Targeted viral vector transduction of relaxin-3 neurons in the rat nucleus incertus using ..

Journal article

Neural Control Of Behavioural State And Cognition

Research Grant

Regulatory peptides and systems biology: A new era of translational and reverse-translatio..

Journal article

Modulation Of Feeding Through Pharmacological Targeting Of The Relaxin-3 Receptor Rxfp3

Research Grant

Functional analysis of an R311C variant of Ca2 -calmodulin-dependent protein kinase kinase..

Projects

Displaying the 12 most recent projects by Andrew Gundlach.

A New Therapeutic Target For Stress-Related Relapse

Relapse and hazardous drinking represent the most difficult clinical problems in treating patients with alcohol use disorders. We have ident..

2015 - 2018

Completed

Neural Control Of Behavioural State And Cognition

Dementia and mental illness are significant social and economic burdens worldwide and knowledge of underlying causes and more effective ther..

2014 - 2016

Completed

Modulation Of Feeding Through Pharmacological Targeting Of The Relaxin-3 Receptor Rxfp3

Relaxin-3 is a neuropeptide that regulates a number of physiological processes, including food intake, suggesting that the relaxin-3 recepto..

2014 - 2016

Completed

Modulatory Control Of Arousal And Affect In Health And Disease

Mental illness is a significant social and economic burden worldwide and knowledge of the underlying causes and more effective therapies are..

2012 - 2014

Completed

How The Brain Regulates Reward

Substance abuse is a significant social and economic burden upon Australian societies and on societies around the world. Treatment remains p..

2012 - 2014

Completed

Neural Control Of Behavioural State In Health And Disease

Our research aims to describe and understand newly identified nerve pathways or 'networks' in brain that control physiological homeostasis o..

2011 - 2016

Completed

Neural Networks And Transmitters Controlling Behavioural State And Cognition

Mental illness and dementia are significant social and economic burdens worldwide and knowledge of their underlying causes and more effectiv..

2011 - 2013

Completed

Research Fellowship - Assoc Prof Andrew Gundlach

I am a neuroscientist employing strategies of anatomy, biochemistry, pharmacology, genetics and behavioural analysis to examine the physiolo..

2010 - 2010

Completed

NHMRC Research Fellowship 2009 - Gundlach

2009 - 2009

Completed

Peptide Neurotransmission In Mental Health And Psychiatric Illness

Our laboratory recently discovered the brain 'transmitter' called 'relaxin-3', and are researching how it affects brain activity and animal ..

2008 - 2010

Completed

Neuroprotection In Multiple Sclerosis

Brain Protection: A new therapeutic approach for Multiple Sclerosis In Multiple Sclerosis (MS), the immune system mistakenly attacks the bra..

2007 - 2009

Completed

Application For Promotion To Prf

I am a neuroscientist employing strategies of anatomy, biochemistry, pharmacology, genetics and behavioural analysis to examine the physiolo..

12

Projects

Project Types

Research Grant

Scholarly Works

Displaying the 295 most recent scholarly works by Andrew Gundlach.

RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via M-like Current Activation and Contributes to Binge Eating Behavior

Alan Kania, Agata Szlaga, Patryk Sambak, Anna Gugula, Ewa Blasiak, Maria Vittoria Micioni Di Bonaventura, Mohammad Akhter Hossain, Carlo Cifani, Grzegorz Hess, Andrew L Gundlach, Anna Blasiak

Journal article | 2020 | The Journal of Neuroscience

Binge-eating disorder is the most common eating disorder. Various neuropeptides play important roles in the regulation of feeding ..

Targeted viral vector transduction of relaxin-3 neurons in the rat nucleus incertus using a novel cell-type specific promoter.

Alexander D Wykes, Sherie Ma, Ross AD Bathgate, Andrew L Gundlach

Journal article | 2020 | IBRO Rep

Modern neuroscience utilizes transgenic techniques extensively to study the activity and function of brain neural networks. A key ..

Regulatory peptides and systems biology: A new era of translational and reverse-translational neuroendocrinology

Lee E Eiden, Andrew L Gundlach, Valery Grinevich, Mary R Lee, Andre S Mecawi, Duan Chen, Ruud M Buijs, Vito S Hernandez, German Fajardo-Dolci, Limei Zhang

Journal article | 2020 | Journal of Neuroendocrinology

Functional analysis of an R311C variant of Ca2 -calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder

Naomi XY Ling, Christopher G Langendorf, Ashfaqul Hoque, Sandra Galic, Kim Loh, Bruce E Kemp, Andrew L Gundlach, Jonathan S Oakhill, John W Scott

Journal article | 2020 | Bipolar Disorders

OBJECTIVES: Loss-of-function mutations in the gene encoding the calcium-calmodulin (Ca2+ -CaM)-dependent protein kinase kinase-2 (..

Effects of chronic silencing of relaxin-3 production in nucleus incertus neurons on food intake, body weight, anxiety-like behaviour and limbic brain activity in female rats

Camila de Avila, Sandrine Chometton, Sherie Ma, Lola Torz Pedersen, Elena Timofeeva, Carlo Cifani, Andrew L Gundlach

Journal article | 2020 | Psychopharmacology

Eating disorders are frequently triggered by stress and are more prevalent in women than men. First signs often appear during earl..

Relaxin-3 receptor (RXFP3) activation in the nucleus of the solitary tract modulates respiratory rate and the arterial chemoreceptor reflex in rat

Werner I Furuya, Rishi R Dhingra, Andrew L Gundlach, Mohammad Akhter Hossain, Mathias Dutschmann

Journal article | 2020 | Respiratory Physiology & Neurobiology

The neuropeptide relaxin-3 is expressed by the pontine nucleus incertus. Relaxin-3 and synthetic agonist peptides modulate arousal..

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors

Stephen PH Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, Thiruma V Arumugam, Andrew Bennett, Benita Sjogren, Christopher Sobey, Szu Shen Wong, Maria P Abbracchio, et al.

Journal article | 2019 | BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concis..

Chronic activation of the relaxin-3 receptor on GABA neurons in rat ventral hippocampus promotes anxiety and social avoidance

Valeria Rytova, Despina E Ganella, David Hawkes, Ross AD Bathgate, Sherie Ma, Andrew L Gundlach

Journal article | 2019 | Hippocampus

Anxiety disorders are highly prevalent in modern society and better treatments are required. Key brain areas and signaling systems..

Relaxin-3 receptor (RXFP3) expression by gaba neurons in hippocampus and amygdala and effects of RXFP3 activation on behaviour

V Rytova, M Nategh, TD Aumann, H Albert-Gasco, CA Reid, RAD Bathgate, FE Oloucha-Bordonau, S Ma, AL Gundlach

Conference Proceedings | 2019 | JOURNAL OF NEUROCHEMISTRY

Oligodendroglial responses to neuronal activity in the developing and adult CNS

B Emery, S Mitew, I Gobius, LR Fenlon, S McDougall, D Hawkes, Y Lulu Xing, H Bujalka, AL Gundlach, LJ Richards, TJ Kilpatrick, T Merson, A Foster

Conference Proceedings | 2019 | GLIA

Brainstem nucleus incertus controls contextual memory formation

Andras Szonyi, Katalin E Sos, Rita Nyilas, Daniel Schlingloff, Andor Domonkos, Virag T Takacs, Balazs Posfai, Panna Hegedus, James B Priestley, Andrew L Gundlach, Attila I Gulyas, Viktor Varga, Attila Losonczy, Tamas F Freund, Gabor Nyiri

Journal article | 2019 | Science

Validation of 'Somnivore', a Machine Learning Algorithm for Automated Scoring and Analysis of Polysomnography Data

Giancarlo Allocca, Sherie Ma, Davide Martelli, Matteo Cerri, Flavia Del Vecchio, Stefano Bastianini, Giovanna Zoccoli, Roberto Amici, Stephen R Morairty, Anne E Aulsebrook, Shaun Blackburn, John A Lesku, Niels C Rattenborg, Alexei L Vyssotski, Emma Wams, Kate Porcherer, Katharina Wulff, Russell Foster, Julia KM Chan, Christian L Nicholas, et al.

Journal article | 2019 | Frontiers in Neuroscience

Manual scoring of polysomnography data is labor-intensive and time-consuming, and most existing software does not account for subj..

Septal GABA and Glutamate Neurons Express RXFP3 mRNA and Depletion of Septal RXFP3 Impaired Spatial Search Strategy and Long-Term Reference Memory in Adult Mice

Mouna Haidar, Kimberly Tin, Cary Zhang, Mohsen Nategh, Joao Covita, Alexander D Wykes, Jake Rogers, Andrew L Gundlach

Journal article | 2019 | FRONTIERS IN NEUROANATOMY

Relaxin-3 is a highly conserved neuropeptide abundantly expressed in neurons of the nucleus incertus (NI), which project to nodes ..

Acquisition of analgesic properties by the cholecystokinin (CCK)/CCK2 receptor system within the amygdala in a persistent inflammatory pain condition

Olivier Roca-Lapirot, Pascal Fossat, Sherie Ma, Karine Egron, Gabriella Trigilio, Maria-Jose Lopez-Gonzalez, Joao Covita, Rabia Bouali-Benazzouz, Alexandre Favereaux, Andrew L Gundlach, Marc Landry

Journal article | 2019 | PAIN

Central relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neurons

Hector Albert-Gasco, Sandra Sanchez-Sarasua, Sherie Ma, Cristina Garcia-Diaz, Andrew L Gundlach, Ana M Sanchez-Perez, Francisco E Olucha-Bordonau

Journal article | 2019 | Brain Structure and Function

Nucleus incertus ablation disrupted conspecific recognition and modified immediate early gene expression patterns in 'social brain' circuits of rats

C Garcia-Diaz, MJ Sanchez-Catalan, E Castro-Salazar, A Garcia-Aviles, H Albert-Gasco, S Sanchez-Sarasus de la Barcena, AM Sanchez-Perez, AL Gundlach, FE Olucha-Bordonau

Journal article | 2019 | Behavioural Brain Research

The effects of relaxin-3 knock down neurons on body weight and food intake in female rats

C De Avila Dal'bo, S Ma, A Gundlach, E Timofeeva, C Cifani

Conference Proceedings | 2019 | European Neuropsychopharmacology

Involvement of Serotonergic and Relaxin-3 Neuropeptide Systems in the Expression of Anxiety-like Behavior

Adam J Lawther, Andrew Flavell, Sherie Ma, Stephen Kent, Christopher A Lowry, Andrew L Gundlach, Matthew W Hale

Journal article | 2018 | Neuroscience

Melanin-concentrating hormone and orexin systems in rat nucleus incertus: Dual innervation, bidirectional effects on neuron activity, and differential influences on arousal and feeding

Azadeh Sabetghadam, Agnieszka Grabowiecka-Nowak, Alan Kania, Anna Gugula, Ewa Blasiak, Tomasz Blasiak, Sherie Ma, Andrew L Gundlach, Anna Blasiak

Journal article | 2018 | Neuropharmacology

Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signaling

Francisco E Olucha-Bordonau, Hector Albert-Gasco, Francisco Ros-Bernal, Valeria Rytova, Emma KE Ong-Palsson, Sherie Ma, Ana M Sanchez-Perez, Andrew L Gundlach

Journal article | 2018 | CNS Neuroscience & Therapeutics

Dual-transmitter systems regulating arousal, attention, learning and memory.

Sherie Ma, Balázs Hangya, Christopher S Leonard, William Wisden, Andrew L Gundlach

Journal article | 2018 | Neuroscience & Biobehavioral Reviews

An array of neuromodulators, including monoamines and neuropeptides, regulate most behavioural and physiological traits. In the pa..

Dual-transmitter systems regulating arousal, attention, learning and memory

Sherie Ma, Balazs Hangya, Christopher S Leonard, William Wisden, Andrew L Gundlach

Conference Proceedings | 2018 | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

Stanislaw Mitew, Ilan Gobius, Laura R Fenlon, Stuart J McDougall, David Hawkes, Yao Lulu Xing, Helena Bujalka, Andrew L Gundlach, Linda J Richards, Trevor J Kilpatrick, Tobias D Merson, Ben Emery

Journal article | 2018 | NATURE COMMUNICATIONS

GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA

Hector Albert-Gasco, Sherie Ma, Francisco Ros-Bernal, Ana M Sanchez-Perez, Andrew L Gundlach, Francisco E Olucha-Bordonau

Journal article | 2018 | FRONTIERS IN NEUROANATOMY

Differential effects of relaxin-3 and a selective relaxin-3 receptor agonist on food and water intake and hypothalamic neuronal activity in rats

Camila de Avila, Sandrine Chometton, Christophe Lenglos, Juliane Calvez, Andrew L Gundlach, Elena Timofeeva

Journal article | 2018 | Behavioural Brain Research

Gram scale preparation of clozapine N-oxide (CNO), a synthetic small molecule actuator for muscarinic acetylcholine DREADDs

Phillip L van der Peet, Christian Gunawan, Alaa Abdul-Ridha, Sherie Ma, Daniel J Scott, Andrew L Gundlach, Ross AD Bathgate, Jonathan M White, Spencer J Williams

Journal article | 2018 | METHODSX

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.

Stephen Ph Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, O Peter Buneman, John A Cidlowski, Arthur Christopoulos, Anthony P Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jamie A Davies, undefined CGTP Collaborators

Journal article | 2017 | British Journal of Pharmacology

The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise over..

"SOMNIVORE", A USER-FRIENDLY PLATFORM FOR AUTOMATED SLEEP SCORING OF ANIMAL AND HUMAN POLYSOMNOGRAPHY DATA

G Allocca, D Freestone, L Johnston, A Gundlach

Conference Proceedings | 2017 | Sleep Medicine

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Stephen PH Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, O Peter Buneman, John A Cidlowski, Arthur Christopoulos, Anthony P Davenport, Doriano Fabbro, Michael Spedding, Jorg Striessnig, Jamie A Davies, MP Abbracchio, R Aldrich, K Al-Hosaini, et al.

Journal article | 2017 | BRITISH JOURNAL OF PHARMACOLOGY

Nucleus incertus corticotrophin-releasing factor 1 receptor signalling regulates alcohol seeking in rats

Leigh C Walker, Hanna E Kastman, Jan A Koeleman, Craig M Smith, Christina J Perry, Elena V Krstew, Andrew L Gundlach, Andrew J Lawrence

Journal article | 2017 | Addiction Biology

Central amygdala relaxin-3/relaxin family peptide receptor 3 signalling modulates alcohol seeking in rats

Leigh C Walker, Hanna E Kastman, Elena V Krstew, Andrew L Gundlach, Andrew J Lawrence

Journal article | 2017 | British Journal of Pharmacology

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

David I Finkelstein, Jessica L Billings, Paul A Adlard, Scott Ayton, Amelia Sedjahtera, Colin L Masters, Simon Wilkins, David M Shackleford, Susan A Charman, Wojciech Bal, Izabela A Zawisza, Ewa Kurowska, Andrew L Gundlach, Sheri Ma, Ashley I Bush, Dominic J Hare, Philip A Doble, Simon Crawford, Elisabeth CL Gautier, Jack Parsons, et al.

Journal article | 2017 | ACTA NEUROPATHOLOGICA COMMUNICATIONS

Inhibition of oxytocin and vasopressin neuron activity in rat hypothalamic paraventricular nucleus by relaxin-3-RXFP3 signalling

Alan Kania, Anna Gugula, Agnieszka Grabowiecka, Camila de Avila, Tomasz Blasiak, Zenon Rajfur, Marian H Lewandowski, Grzegorz Hess, Elena Timofeeva, Andrew L Gundlach, Anna Blasiak

Journal article | 2017 | The Journal of Physiology

Relaxin-3/RXFP3 signalling in mouse hypothalamus: no effect of RXFP3 activation on corticosterone, despite reduced presynaptic excitatory input onto paraventricular CRH neurons in vitro

C Zhang, DV Baimoukhametova, CM Smith, JS Bains, Andrew L Gundlach

Journal article | 2017 | Psychopharmacology

Relaxin' the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders

Jigna Rajesh Kumar, Ramamoorthy Rajkumar, Tharindunee Jayakody, Subhi Marwari, Jia Mei Hong, Sherie Ma, Andrew L Gundlach, Mitchell KP Lai, Gavin S Dawe

Journal article | 2017 | BRITISH JOURNAL OF PHARMACOLOGY

Cover Image, Volume 27, Issue 5

M Haidar, G Guèvremont, C Zhang, RAD Bathgate, E Timofeeva, CM Smith, AL Gundlach

Journal article | 2017 | Hippocampus

Relaxin-3 Inputs Target Hippocampal Interneurons and Deletion of Hilar Relaxin-3 Receptors in "Floxed-RXFP3" Mice Impairs Spatial Memory

M Haidar, G Guevremont, C Zhang, RAD Bathgate, E Timofeeva, CM Smith, AL Gundlach

Journal article | 2017 | Hippocampus

Distribution, physiology and pharmacology of relaxin-3/RXFP3 systems in brain

Sherie Ma, Craig M Smith, Anna Blasiak, Andrew L Gundlach

Journal article | 2017 | British Journal of Pharmacology

Interactions of Circadian Rhythmicity, Stress and Orexigenic Neuropeptide Systems: Implications for Food Intake Control

Anna Blasiak, Andrew L Gundlach, Grzegorz Hess, Marian H Lewandowski

Journal article | 2017 | FRONTIERS IN NEUROSCIENCE

Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory

Hector Albert-Gasco, Alvaro Garcia-Aviles, Salma Moustafa, Sandra Sanchez-Sarasua, Andrew L Gundlach, Francisco E Olucha-Bordonau, Ana M Sanchez-Perez

Journal article | 2017 | Brain Structure and Function

Nucleus incertus promotes cortical desynchronization and behavioral arousal

Sherie Ma, Giancarlo Allocca, Emma KE Ong-Palsson, Caitlin E Singleton, David Hawkes, Stuart J McDougall, Spencer J Williams, Ross AD Bathgate, Andrew L Gundlach

Journal article | 2017 | Brain Structure and Function

Nucleus incertus Orexin(2) receptors mediate alcohol seeking in rats

Hanna E Kastman, Anna Blasiak, Leigh Walker, Marcin Siwiec, Elena V Krstew, Andrew L Gundlach, Andrew J Lawrence

Journal article | 2016 | Neuropharmacology

Development of a Single-Chain Peptide Agonist of the Relaxin-3 Receptor Using Hydrocarbon Stapling

Keiko Hojo, Mohammed Akhter Hossain, Julien Tailhades, Fazel Shabanpoor, Lilian LL Wong, Emma EK Ong-Palsson, Hanna E Kastman, Sherie Ma, Andrew L Gundlach, K Johan Rosengren, John D Wade, Ross AD Bathgate

Journal article | 2016 | Journal of Medicinal Chemistry

Comparative Distribution of Relaxin-3 Inputs and Calcium-Binding Protein-Positive Neurons in Rat Amygdala

Fabio N Santos, Celia W Pereira, Ana M Sanchez-Perez, Marcos Otero-Garcia, Sherie Ma, Andrew L Gundlach, Francisco E Olucha-Bordonau

Journal article | 2016 | FRONTIERS IN NEUROANATOMY

Sensitivity to Chronic Methamphetamine Administration and Withdrawal in Mice with Relaxin-3/RXFP3 Deficiency

Mouna Haidar, Monica Lam, Berenice E Chua, Craig M Smith, Andrew L Gundlach

Journal article | 2016 | Neurochemical Research

Role of relaxin-3/RXFP3 system in stress-induced binge-like eating in female rats

Juliane Calvez, Camila de Avila, Louis-Olivier Matte, Genevieve Guevremont, Andrew L Gundlach, Elena Timofeeva

Journal article | 2016 | Neuropharmacology

Special Issue in Honour of Philip M Beart Foreword

Andrew J Lawrence, Andrew L Gundlach

Journal article | 2016 | Neurochemical Research

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Overview

Stephen PH Alexander, Eamonn Kelly, Neil Marrion, John A Peters, Helen E Benson, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Christopher Southan, O Peter Buneman, William A Catterall, John A Cidlowski, Anthony P Davenport, Doriano Fabbro, Grace Fan, John C McGrath, Michael Spedding, Jamie A Davies, R Aldrich, B Attali, et al.

Journal article | 2015 | British Journal of Pharmacology

Excitatory orexinergic innervation of rat nucleus incertus - Implications for ascending arousal, motivation and feeding control

Anna Blasiak, Marcin Siwiec, Agnieszka Grabowiecka, Tomasz Blasiak, Anna Czerw, Ewa Blasiak, Alan Kania, Zenon Rajfur, Marian H Lewandowski, Andrew L Gundlach

Journal article | 2015 | Neuropharmacology

Relaxin-3 receptor (Rxfp3) gene deletion reduces operant sucrose-but not alcohol-responding in mice

AW Walker, CM Smith, AL Gundlach, AJ Lawrence

Journal article | 2015 | Genes, Brain and Behavior

Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice

Cary Zhang, Berenice E Chua, Annie Yang, Faze Shabanpoor, Mohammad Akhter Hossain, John D Wade, K Johan Rosengren, Craig M Smith, Andrew L Gundlach

Journal article | 2015 | Behavioural Brain Research

ANXIOGENIC DRUG ADMINISTRATION AND ELEVATED PLUS-MAZE EXPOSURE IN RATS ACTIVATE POPULATIONS OF RELAXIN-3 NEURONS IN THE NUCLEUS INCERTUS AND SEROTONERGIC NEURONS IN THE DORSAL RAPHE NUCLEUS

AJ Lawther, ML Clissold, S Ma, S Kent, CA Lowry, AL Gundlach, MW Hale

Journal article | 2015 | Neuroscience

Involvement of central relaxin-3 signalling in sodium (salt) appetite

Craig M Smith, Lesley L Walker, Berenice E Chua, Michael J McKinley, Andrew L Gundlach, Derek A Denton, Andrew J Lawrence

Journal article | 2015 | EXPERIMENTAL PHYSIOLOGY

RELAXIN-3/RXFP3 and the septohippocampal pathway: effects on learning and memory of viral-based RXFP3 changes in transgenic mice

M Haidar, D Hawkes, G Guevremont, S Ma, R Bathgate, E Timofeeva, C Smith, A Gundlach

Conference Proceedings | 2015 | JOURNAL OF NEUROCHEMISTRY

RELAXIN-3/RXFP3 systems and central stress- and anxiety-related circuits in mice

C Zhang, A Yang, B Chua, G Guevremont, E Timofeeva, C Smith, A Gundlach

Conference Proceedings | 2015 | JOURNAL OF NEUROCHEMISTRY

OREXIN2 (OX2) receptors in nucleus incertus mediate stress-induced reinstatement of alcohol-seeking in alcohol-preferring (IP) rat

H Kastman, A Blasiak, M Siwiec, E Krstew, A Gundlach, A Lawrence

Conference Proceedings | 2015 | JOURNAL OF NEUROCHEMISTRY

Nucleus incertus networks and their influence on arousal and cognition: dreadd studies

E Ong-Palsson, S Ma, D Hawkes, S McDougall, M White, R Barthgate, A Gundlach

Conference Proceedings | 2015 | JOURNAL OF NEUROCHEMISTRY

RELAXIN-3/RXFP3 signalling promotes motivational drive and stress resilience in mice

C Smith, I Hosken, A Walker, B Chua, C Zhang, D Denton, M McKinley, A Lawrence, E Timofeeva, A Gundlach

Conference Proceedings | 2015 | JOURNAL OF NEUROCHEMISTRY

Ascending Control of Arousal and Motivation: Role of Nucleus Incertus and its Peptide Neuromodulators in Behavioural Responses to Stress

S Ma, AL Gundlach

Journal article | 2015 | Journal of Neuroendocrinology

Galanin is an Autocrine Myelin and Oligodendrocyte Trophic Signal Induced by Leukemia Inhibitory Factor

Melissa M Gresle, Helmut Butzkueven, Victoria M Perreau, Anna Jonas, Junhua Xiao, Stefan Thiem, Fiona E Holmes, William Doherty, Pik-Ying Soo, Michele D Binder, Rainer Akkermann, Vilija G Jokubaitis, Holly S Cate, Mark P Marriott, Andrew L Gundlach, David Wynick, Trevor J Kilpatrick

Journal article | 2015 | Glia

Relaxin-3 Receptor (RXFP3) Signalling Mediates Stress-Related Alcohol Preference in Mice

Andrew W Walker, Craig M Smith, Berenice E Chua, Elena V Krstew, Cary Zhang, Andrew L Gundlach, Andrew J Lawrence

Journal article | 2015 | PLOS ONE

Septal Projections to Nucleus Incertus in the Rat: Bidirectional Pathways for Modulation of Hippocampal Function

Ana M Sanchez-Perez, Isabel Arnal-Vicente, Fabio N Santos, Celia W Pereira, Nisrin ElMlili, Julio Sanjuan, Sherie Ma, Andrew L Gundlach, Francisco E Olucha-Bordonau

Journal article | 2015 | Journal of Comparative Neurology

Relaxin-3 receptor (Rxfp3) gene knockout mice display reduced running wheel activity: Implications for role of relaxin-3/RXFP3 signalling in sustained arousal

Ihaia T Hosken, Steven W Sutton, Craig M Smith, Andrew L Gundlach

Journal article | 2015 | Behavioural Brain Research

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

Roland Lang, Andrew L Gundlach, Fiona E Holmes, Sally A Hobson, David Wynick, Tomas Hoekfelt, Barbara Kofler

Journal article | 2015 | Pharmacological Reviews

Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice

Craig M Smith, Berenice E Chua, Cary Zhang, Andrew W Walker, Mouna Haidar, David Hawkes, Fazel Shabanpoor, Mohammad Akhter Hossain, John D Wade, K Johan Rosengren, Andrew L Gundlach

Journal article | 2014 | BEHAVIOURAL BRAIN RESEARCH

Relaxin-3 mRNA levels in nucleus incertus correlate with alcohol and sucrose intake in rats

PJ Ryan, EV Krstew, M Sarwar, AL Gundlach, AJ Lawrence

Journal article | 2014 | DRUG AND ALCOHOL DEPENDENCE

Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuro psychiatric diseases?

Craig M Smith, Andrew W Walker, Ihaia T Hosken, Berenice E Chua, Cary Zhang, Mouna Haidar, Andrew L Gundlach

Journal article | 2014 | FRONTIERS IN PHARMACOLOGY

Relaxin-3/RXFP3 system regulates alcohol-seeking

Philip J Ryan, Hanna E Kastman, Elena V Krstew, K Johan Rosengren, Mohammed Akhter Hossain, Leonid Churilov, John D Wade, Andrew L Gundlach, Andrew J Lawrence

Journal article | 2013 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relaxins

AL Gundlach, CM Smith, PJ Ryan, A Blasiak, FE Olucha-Bordonau, S Ma

Book Chapter | 2013

Galanin and GALP

AL Gundlach, PJ Ryan

Book Chapter | 2013

Heterogeneous responses of nucleus incertus neurons to corticotrophin-releasing factor and coherent activity with hippocampal theta rhythm in the rat

Sherie Ma, Anna Blasiak, Francisco E Olucha-Bordonau, Anthony JM Verberne, Andrew L Gundlach

Journal article | 2013 | JOURNAL OF PHYSIOLOGY-LONDON

Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus

DE Ganella, GE Callander, S Ma, CR Bye, AL Gundlach, RAD Bathgate

Journal article | 2013 | Gene Therapy

Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus

DE Ganella, GE Callander, S Ma, CR Bye, AL Gundlach, RAD Bathgate

Journal article | 2013 | Gene Therapy

Electrolytic lesion of the nucleus incertus retards extinction of auditory conditioned fear

CW Pereira, FN Santos, AM Sanchez-Perez, M Otero-Garcia, M Marchioro, S Ma, AL Gundlach, FE Olucha-Bordonau

Journal article | 2013 | Behavioural Brain Research

Chemical synthesis and orexigenic activity of rat/mouse relaxin-3

Mohammed Akhter Hossain, Craig M Smith, Philip J Ryan, Elena Buechler, Ross AD Bathgate, Andrew L Gundlach, John D Wade

Journal article | 2013 | AMINO ACIDS

Central relaxin-3 receptor (RXFP3) activation decreases anxiety- and depressive-like behaviours in the rat

Philip J Ryan, Elena Buechler, Fazel Shabanpoor, Mohammed Akhter Hossain, John D Wade, Andrew J Lawrence, Andrew L Gundlach

Journal article | 2013 | BEHAVIOURAL BRAIN RESEARCH

Relaxin-3 innervation of the intergeniculate leaflet of the rat thalamus - neuronal tract-tracing and in vitro electrophysiological studies

Anna Blasiak, Tomasz Blasiak, Marian H Lewandowski, Mohammed Akhter Hossain, John D Wade, Andrew L Gundlach

Journal article | 2013 | European Journal of Neuroscience

Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization

Linda J Chan, Craig M Smith, Berenice E Chua, Feng Lin, Ross AD Bathgate, Frances Separovic, Andrew L Gundlach, Mohammed Akhter Hossain, John D Wade

Journal article | 2013 | FRONTIERS IN CHEMISTRY

Relaxin-3/RXFP3 signaling and neuroendocrine function: perspective on extrinsic hypothalamic control

DE Ganella, S Ma, AL Gundlach

Journal article | 2013 | Frontiers in Endocrinology

Complex neural circuits within the hypothalamus that govern essential autonomic processes and associated behaviors signal using am..

Potential hypothalamic targets of relaxin-3 innervation: a perspective.

Craig M Smith, Berenice E Chua, Andrew W Walker, Andrew L Gundlach

Journal article | 2013 | Italian Journal of Anatomy and Embryology

Relaxin-3 is a recently identified neuropeptide transmitter primarily expressed by neurons of the pontine nucleus incertus, which ..

Viral-mediated delivery of an RXFP3 agonist into brain promotes arousal in mice.

Craig M Smith, Anna Blasiak, Despina E Ganella, Berenice E Chua, Sharon L Layfield, Ross AD Bathgate, Andrew L Gundlach

Journal article | 2013 | Italian Journal of Anatomy and Embryology

Anatomical and functional studies of central relaxin-3/RXFP3 systems suggest they constitute an ascending arousal network. For exa..

Pharmacological activation of RXFP3 is not orexigenic in C57BL/6J mice.

Craig M Smith, Ihaia T Hosken, Natalie L Downer, Berenice E Chua, Mohammad Akhter Hossain, John D Wade, Andrew L Gundlach

Journal article | 2013 | Italian Journal of Anatomy and Embryology

The neuropeptide relaxin-3 and its cognate G-protein-coupled receptor, RXFP3, have been implicated in the control of feeding behav..

Consequences of relaxin-3 null mutation in mice on food-entrainable arousal.

Ihaia T Hosken, Craig M Smith, Berenice E Chua, Andrew L Gundlach

Journal article | 2013 | Italian Journal of Anatomy and Embryology

Relaxin-3/RXFP3 networks have been hypothesised to influence behavioural state based on their anatomical distribution and recent e..

Elimination of RXFP3 signalling causes reduced circadian voluntary wheel running in mice: implications for Relaxin-3 networks in arousal and sleep control

IT Hosken, C Smith, A Blasiak, AL Gundlach

Conference Proceedings | 2012 | JOURNAL OF SLEEP RESEARCH

Increased feeding and body weight gain in rats after acute and chronic activation of RXFP3 by relaxin-3 and receptor-selective peptides: functional and therapeutic implications

Despina E Ganella, Philip J Ryan, Ross AD Bathgate, Andrew L Gundlach

Journal article | 2012 | Behavioural Pharmacology

Silencing Relaxin-3 in Nucleus Incertus of Adult Rodents: A Viral Vector-based Approach to Investigate Neuropeptide Function

Gabrielle E Callander, Sherie Ma, Despina E Ganella, Verena C Wimmer, Andrew L Gundlach, Walter G Thomas, Ross AD Bathgate

Journal article | 2012 | PLOS ONE

Distribution and targets of the relaxin-3 innervation of the septal area in the rat

Francisco E Olucha-Bordonau, Marcos Otero-Garcia, Ana M Sanchez-Perez, Angel Nunez, Sherie Ma, Andrew L Gundlach

Journal article | 2012 | Journal of Comparative Neurology

Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

Fazel Shabanpoor, Mohammad Alchter Hossain, Philip J Ryan, Alessia Belgi, Sharon Layfield, Martina Kocan, Suode Zhang, Chrishan S Samuel, Andrew L Gundlach, Ross AD Bathgate, Frances Separovic, John D Wade

Journal article | 2012 | Journal of Medicinal Chemistry

Relaxin-3 null mutation mice display a circadian hypoactivity phenotype

CM Smith, IT Hosken, SW Sutton, AJ Lawrence, AL Gundlach

Journal article | 2012 | Genes, Brain and Behavior

Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

F Shabanpoor, M Hossain, PJ Ryan, A Belgi, SL Layfield, undefined Kocan, undefined Zhang, C Samuel, AL Gundlach, R Bathgate, F Separovic, JD Wade

Journal article | 2012 | Journal of Medicinal Chemistry

Relaxin-3 systems in the brain-The first 10 years

Craig M Smith, Philip J Ryan, Ihaia T Hosken, Sherie Ma, Andrew L Gundlach

Journal article | 2011 | Journal of Chemical Neuroanatomy

Relaxin family peptide receptor 4- RXFP4 (GPCR142)

A Gundlach

Book Chapter | 2011

CIRCADIAN HYPOACTIVITY IN RELAXIN-3 KNOCKOUT MICE AND ACTIVITY/FEEDING EFFECTS FOLLOWING PHARMACOLOGICAL RXFP3 MANIPULATION

CM Smith, IT Hosken, MA Hossain, F Shabanpoor, SW Sutton, JD Wade, AL Gundlach

Conference Proceedings | 2011 | JOURNAL OF NEUROCHEMISTRY

ADENO-ASSOCIATED VIRUS MEDIATED DELIVERY OF PEPTIDE AGONISTS INTO THE RAT BRAIN

DE Ganella, GE Callander, S Ma, TJ McCown, AL Gundlach, RA Bathgate

Conference Proceedings | 2011 | JOURNAL OF NEUROCHEMISTRY

Nucleus incertus-An emerging modulatory role in arousal, stress and memory

Philip J Ryan, Sherie Ma, Francisco E Olucha-Bordonau, Andrew L Gundlach

Journal article | 2011 | Neuroscience and Biobehavioral Reviews

Design, Synthesis, and Characterization of a Single-Chain Peptide Antagonist for the Relaxin-3 Receptor RXFP3

Linda M Haugaard-Kedstrom, Fazel Shabanpoor, Mohammed Akhter Hossain, Richard J Clark, Philip J Ryan, David J Craik, Andrew L Gundlach, John D Wade, Ross AD Bathgate, K Johan Rosengren

Journal article | 2011 | Journal of the American Chemical Society

Distribution of Relaxin-3 and RXFP3 Within Arousal, Stress, Affective, and Cognitive Circuits of Mouse Brain

Craig M Smith, Pei-Juan Shen, Avantika Banerjee, Pascal Bonaventure, Sherie Ma, Ross AD Bathgate, Steven W Sutton, Andrew L Gundlach

Journal article | 2010 | Journal of Comparative Neurology

Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF(1) activation.

A Banerjee, PJ Shen, SK MA, R BATHGATE, A GUNDLACH

Journal article | 2010 | Neuropharmacology

Relaxin-3

AL Gundlach

Book Chapter | 2010

Galanin Systems and Ischemia: Peptide and Receptor Plasticity in Neurons and Oligodendroglial Precursors

Pei-Juan Shen, Andrew L Gundlach

Journal article | 2010 | EXS

Galanin in Glia: Expression and Potential Roles in the CNS

Helmut Butzkueven, Andrew L Gundlach

Book Chapter | 2010 | EXS

Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation

Avantika Banerjee, Pei-Juan Shen, Sherie Ma, Ross AD Bathgate, Andrew L Gundlach

Journal article | 2010 | Neuropharmacology

Localization of Relaxin-3 in Brain of Macaca fascicularis: Identification of a Nucleus Incertus in Primate

Sherie Ma, Qian Sang, Jose L Lanciego, Andrew L Gundlach

Journal article | 2009 | Journal of Comparative Neurology

Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus

Sherie Ma, Francisco E Olucha-Bordonau, M Akhter Hossain, Feng Lin, Chester Kuei, Changlu Liu, John D Wade, Steven W Sutton, Angel Nunez, Andrew L Gundlach

Journal article | 2009 | Learning and memory

Relaxin-3/RXFP3 networks in brain: putative roles in behavioral state, stress, biorhthyms and cognition

AL Gundlach

Conference Proceedings | 2009 | NEUROPEPTIDES

RELAXIN-3 MAY MODULATE EMOTIONAL FUNCTION VIA ITS PARTICULAR DISTRIBUTION IN THE AMYGDALA COMPLEX

FE Olucha-Bordonau, E Lanuza, S Ma, AL Gundlach

Conference Proceedings | 2009 | NEUROPEPTIDES

RELAXIN-3 INNERVATION AND MODULATION OF THE INTERGENICULATE LEAFLET OF THE RAT THALAMUS

A Blasiak, T Blasiak, MA Hossain, JD Wade, AL Gundlach, MH Lewandowski

Conference Proceedings | 2009 | NEUROPEPTIDES

A role for galanin in human and experimental inflammatory demyelination

David C Wraith, Robert Pope, Helmut Butzkueven, Heidi Holder, Penny Vanderplank, Pauline Lowrey, Michael J Day, Andrew L Gundlach, Trevor J Kilpatrick, Neil Scolding, David Wynick

Journal article | 2009 | Proceedings of the National Academy of Sciences of the United States of America

Effect of unilateral lesion of the nigrostriatal dopamine pathway on survival and neurochemistry of parafascicular nucleus neurons in the rat - Evaluation of time-course and LGR8 expression

Katayoun Sedahat, David I Finkelstein, Andrew L Gundlach

Journal article | 2009 | Brain Research

Proceedings of the 2007 International Brain Research Organisation Satellite Meeting "Movement Disorders: Focus on the Thalamus and Basal Ganglia" held in Sydney, Australia, 10-11 July 2007

Jasmine M Henderson

Journal article | 2009 | Brain Research Bulletin

Distribution of Relaxin-3 mRNA and Immunoreactivity and RXFP3-Binding Sites in the Brain of the Macaque, Macaca fascicularis

Sherie Ma, Pei-Juan Shen, Qian Sang, Jose L Lanciego, Andrew L Gundlach

Journal article | 2009 | Annals of The New York Academy of Sciences

Verification of a Relaxin-3 Knockout/LacZ Reporter Mouse as a Model of Relaxin-3 Deficiency

Craig M Smith, Pei-Juan Shen, Sherie Ma, Steve W Sutton, Andrew L Gundlach

Journal article | 2009 | Annals of The New York Academy of Sciences

Structure and Activity in the Relaxin Family of Peptides

Geoffrey W Tregear, Ross AD Bathgate, Mohammed Akhter Hossain, Feng Lin, Suode Zhang, Fazel Shabanpoor, Daniel J Scott, Sherie Ma, Andrew L Gundlach, Chrishan S Samuel, John D Wade

Journal article | 2009 | Annals of The New York Academy of Sciences

Metabolic and Neuroendocrine Responses to RXFP3 Modulation in the Central Nervous System

Steven W Sutton, Jonathan Shelton, Craig Smith, John Williams, Sujin Yun, Timothy Motley, Chester Kuei, Pascal Bonaventure, Andrew Gundlach, Changlu Liu, Timothy Lovenberg

Conference Proceedings | 2009 | Annals of the New York Academy of Sciences

Relaxin Family Peptides and Receptors in Mammalian Brain Anatomical Insights and Diverse Functional Possibilities

Andrew L Gundlach, Sherie Ma, Qian Sang, Pei-Juan Shen, Loretta Piccenna, Katayoun Sedaghat, Craig M Smith, Ross AD Bathgate, Andrew J Lawrence, Geoffrey W Tregear, John D Wade, David I Finkelstein, Pascal Bonaventure, Changlu Liu, Timothy W Lovenberg, Steve W Sutton

Journal article | 2009 | Annals of The New York Academy of Sciences

Leucine-rich repeat-containing G-protein-coupled receptor 8 in the rat brain: Enrichment in thalamic neurons and their efferent projections

K Sedaghat, PJ Shen, DI Finkelstein, JM Henderson, AL Gundlach

Journal article | 2008 | Neuroscience

Relaxin receptor-LGR7 (RXFP1)

AL Gundlach, L Piccenna

Book Chapter | 2008

Relaxin family peptide receptor 3- RXFP3 (GPCR135)

A Gundlach, CM Smith

Book Chapter | 2008

The galanin peptide family: Receptor phan-nacology, pleiotropic biological actions, and implications in health and disease

Roland Lang, Andrew L Gundlach, Barbara Kofler

Journal article | 2007 | Pharmacology & Therapeutics

Galanin treatment offsets the inhibition of bone formation and downregulates the increase in mouse calvarial expression of TNF alpha and GalR2 mRNA induced by chronic daily injections of an injurious vehicle

AC McDonald, JA Schuijers, AL Gundlach, BL Grills

Journal article | 2007 | Bone

Gal2 galanin receptor

A Gundlach

Book Chapter | 2007

Galanin receptors

A Gundlach

Book Chapter | 2007

GAL1 galanin receptor

A Gundlach

Book Chapter | 2007

Relaxin-family peptide and receptor systems in brain: Insights from recent anatomical and functional studies

Sherie Ma, Andrew L Gundlach

Journal article | 2007 | Advances in Experimental Medicine and Biology

GAL3 galanin receptor

A Gundlach

Book Chapter | 2007

Neurochemical phenotype of LGR7-positive neurons in mouse brain? Studies in the LGR7-knock-out/LacZ-knock-in mouse

LG Piccenna, P-J Shen, S Ma, RAD Bathgate, S Mosselmann, AL Gundlach

Conference Proceedings | 2006 | Frontiers in Neuroendocrinology

Leucine-rich repeat-containing G-protein-coupled receptor 8 in mature glomeruli of developing and adult rat kidney and inhibition by insulin-like peptide-3 of glomerular cell proliferation

P Fu, P-J Shen, C-X Zhao, DJ Scott, CS Samuel, JD Wade, GW Tregear, RAD Bathgate, AL Gundlach

Journal article | 2006 | Journal of Endocrinology

Relaxin-3: Improved synthesis strategy and demonstration of its high-affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo

RAD Bathgate, F Lin, NF Hanson, L Otvos, A Guidolin, C Giannakis, S Bastiras, SL Layfield, T Ferraro, S Ma, CX Zhao, AL Gundlach, CS Samuel, GW Tregear, JD Wade

Journal article | 2006 | Biochemistry

Comparative localization of leucine-rich repeat-containing G-protein-coupled receptor-7 (RXFP1) mRNA and [P-33]-relaxin binding sites in rat brain: Restricted somatic co-expression a clue to relaxin action?

S Ma, P-J Shen, TCD Burazin, GW Tregear, AL Gundlach

Journal article | 2006 | Neuroscience

Galanin and GALP Systems in Brain-Molecular Pharmacology, Anatomy, and Putative Roles in Physiology and Pathology

Andrew L Gundlach, Sebastian R-F Jungnickel

Book Chapter | 2006

Comparative localization of LGR7 (RXFP1) mRNA and [33P]-relaxin binding sites in rat brain: restricted somatic co-expression a clue to functional effects?

SK MA, J Shen, CD Burazin, G TREGEAR, A GUNDLACH

Journal article | 2006 | Neuroscience

Relaxin receptor activation in the basolateral amygdala impairs memory consolidation

S Ma, B Roozendaal, TCD Burazin, GW Tregear, JL McGaugh, AL Gundlach

Journal article | 2005 | European Journal of Neuroscience

Relaxin peptide-receptor systems in brain: Insights into anatomy, regulation and signalling

A Gundlach, S Ortinau, P Shen, L Piccenna, A Banerjee, C Smith, S Ma, F Lin, T Burazin, J Wade, R Bathgate, G Tregear

Conference Proceedings | 2005 | JOURNAL OF NEUROCHEMISTRY

Exaggerated feeding response to central galanin-like peptide administration in diet-induced obese rats

HM Tan, AL Gundlach, MJ Morris

Journal article | 2005 | Neuropeptides

Galanin in neuro(glio)genesis: expression of galanin and receptors by progenitor cells in vivo and in vitro and effects of galanin on neurosphere proliferation

PJ Shen, CG Yuan, J Ma, S Cheng, M Yao, AM Turnley, AL Gundlach

Journal article | 2005 | Neuropeptides

Induction of galanin receptor-1 (GalR1) expression in external granule cell layer of post-natal mouse cerebellum

SRF Jungnickel, M Yao, PJ Shen, AL Gundlach

Journal article | 2005 | Journal of Neurochemistry

[I-125]-galanin binding in brain of wildtype, and galanin and GalRr1-knockout in mice: strain and species differences GalR1 density and distribution

SRF Jungnickel, AL Gundlach

Journal article | 2005 | Neuroscience