Andrew Gundlach

A novel receptor, and compounds which bind thereto

WJ LOUIS, EL CONWAY, AL GUNDLACH, D IAKOVIDIS, SNS LOUIS, PMK KING, TL NERO

Differential Level of RXFP3 Expression in Dopaminergic Neurons Within the Arcuate Nucleus, Dorsomedial Hypothalamus and Ventral Tegmental Area of RXFP3-Cre/tdTomato Mice

Lara M Voglsanger, Justin Read, Sarah S Ch'ng, Cary Zhang, Izel M Eraslan, Laura Gray, Leni R Rivera, Lee D Hamilton, Richard Williams, Andrew L Gundlach, Craig M Smith

Journal article  |  2021  |  Frontiers in Neuroscience

RXFP3 (relaxin-family peptide 3 receptor) is the cognate G-protein-coupled receptor for the neuropeptide, relaxin-3. RXFP3 is expr..

RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via M-like Current Activation and Contributes to Binge Eating Behavior

Alan Kania, Agata Szlaga, Patryk Sambak, Anna Gugula, Ewa Blasiak, Maria Vittoria Micioni Di Bonaventura, Mohammad Akhter Hossain, Carlo Cifani, Grzegorz Hess, Andrew L Gundlach, Anna Blasiak

Journal article  |  2020  |  The Journal of Neuroscience

Binge-eating disorder is the most common eating disorder. Various neuropeptides play important roles in the regulation of feeding ..

Targeted viral vector transduction of relaxin-3 neurons in the rat nucleus incertus using a novel cell-type specific promoter

Alexander D Wykes, Sherie Ma, Ross AD Bathgate, Andrew L Gundlach

Journal article  |  2020  |  IBRO Reports

Modern neuroscience utilizes transgenic techniques extensively to study the activity and function of brain neural networks. A key ..

Regulatory peptides and systems biology: A new era of translational and reverse-translational neuroendocrinology

Lee E Eiden, Andrew L Gundlach, Valery Grinevich, Mary R Lee, Andre S Mecawi, Duan Chen, Ruud M Buijs, Vito S Hernandez, German Fajardo-Dolci, Limei Zhang

Journal article  |  2020  |  Journal of Neuroendocrinology

Functional analysis of an R311C variant of Ca2 -calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder

Naomi XY Ling, Christopher G Langendorf, Ashfaqul Hoque, Sandra Galic, Kim Loh, Bruce E Kemp, Andrew L Gundlach, Jonathan S Oakhill, John W Scott

Journal article  |  2020  |  Bipolar Disorders

OBJECTIVES: Loss-of-function mutations in the gene encoding the calcium-calmodulin (Ca2+ -CaM)-dependent protein kinase kinase-2 (..

Effects of chronic silencing of relaxin-3 production in nucleus incertus neurons on food intake, body weight, anxiety-like behaviour and limbic brain activity in female rats

Camila de Avila, Sandrine Chometton, Sherie Ma, Lola Torz Pedersen, Elena Timofeeva, Carlo Cifani, Andrew L Gundlach

Journal article  |  2020  |  Psychopharmacology

Eating disorders are frequently triggered by stress and are more prevalent in women than men. First signs often appear during earl..

Relaxin-3 receptor (RXFP3) activation in the nucleus of the solitary tract modulates respiratory rate and the arterial chemoreceptor reflex in rat

Werner I Furuya, Rishi R Dhingra, Andrew L Gundlach, Mohammad Akhter Hossain, Mathias Dutschmann

Journal article  |  2020  |  Respiratory Physiology & Neurobiology

The neuropeptide relaxin-3 is expressed by the pontine nucleus incertus. Relaxin-3 and synthetic agonist peptides modulate arousal..

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors

Stephen PH Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, Thiruma V Arumugam, Andrew Bennett, Benita Sjogren, Christopher Sobey, Szu Shen Wong, Maria P Abbracchio, et al.

Journal article  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concis..

Chronic activation of the relaxin-3 receptor on GABA neurons in rat ventral hippocampus promotes anxiety and social avoidance

Valeria Rytova, Despina E Ganella, David Hawkes, Ross AD Bathgate, Sherie Ma, Andrew L Gundlach

Journal article  |  2019  |  Hippocampus

Anxiety disorders are highly prevalent in modern society and better treatments are required. Key brain areas and signaling systems..

Relaxin-3 receptor (RXFP3) expression by gaba neurons in hippocampus and amygdala and effects of RXFP3 activation on behaviour

V Rytova, M Nategh, TD Aumann, H Albert-Gasco, CA Reid, RAD Bathgate, FE Oloucha-Bordonau, S Ma, AL Gundlach

Conference Proceedings  |  2019  |  JOURNAL OF NEUROCHEMISTRY