Jeffrey Zajac

Australian endocrinologists need more training in transgender health: A national survey

Ingrid Bretherton, Mathis Grossmann, Shalem Y Leemaqz, Jeffrey D Zajac, Ada S Cheung

Journal article  |  2020  |  Clinical Endocrinology

OBJECTIVE: An increasing number of trans and gender diverse (TGD) individuals are seeking gender-affirming hormone therapy for gen..

Diabetes and higher HbA1c levels are independently associated with adverse renal outcomes in inpatients following multiple hospital admissions.

N Torkamani, L Churilov, R Robbins, G Jerums, V Beik, N Radcliffe, S Patterson, R Bellomo, J Burns, GK Hart, Q Lam, DA Power, RJ MacIsaac, DF Johnson, J Zajac, EI Ekinci

Journal article  |  2020  |  Journal of Diabetes and its Complications

OBJECTIVE: To assess the association between glycaemic status prior to the first hospital presentation with developing adverse ren..

Health Needs of Trans and Gender Diverse Adults in Australia: A Qualitative Analysis of a National Community Survey.

Sav Zwickl, Alex Wong, Ingrid Bretherton, Max Rainier, Daria Chetcuti, Jeffrey D Zajac, Ada S Cheung

Journal article  |  2019  |  International Journal of Environmental Research and Public Health

There is an increasing demand for trans and gender diverse (TGD) health services worldwide. Given the unique and diverse healthcar..

Prevalence of Autism Spectrum Disorder and Attention-Deficit Hyperactivity Disorder Amongst Individuals with Gender Dysphoria: A Systematic Review.

Emily Thrower, Ingrid Bretherton, Ken C Pang, Jeffrey D Zajac, Ada S Cheung

Journal article  |  2019  |  Journal of Autism and Developmental Disorders

Autism spectrum disorders (ASD) and attention-deficit hyperactivity disorder (ADHD) can compromise health and may be more prevalen..

Feasibility of using a transition diabetes team to commence injectable therapies postdischarge from a tertiary hospital: a pilot, randomised controlled trial

Felicity Pyrlis, Rajna Ogrin, Sonja Arthur, Cathy Zhai, Leonid Churilov, Sara Baqar, Jeffrey D Zajac, Elif I Ekinci

Journal article  |  2019  |  BMJ Open

OBJECTIVES: This study aimed to investigate if the use of a transition team was feasible for patients with diabetes being discharg..

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways.

Megan M Weivoda, Ming Ruan, Christine M Hachfeld, Larry Pederson, Alan Howe, Rachel A Davey, Jeffrey D Zajac, Yasuhiro Kobayashi, Bart O Williams, Jennifer J Westendorf, Sundeep Khosla, Merry Jo Oursler

Journal article  |  2019  |  Journal of Bone and Mineral Research

Position statement on the hormonal management of adult transgender and gender diverse individuals

Ada S Cheung, Katie Wynne, Jaco Erasmus, Sally Murray, Jeffrey D Zajac

Journal article  |  2019  |  Medical Journal of Australia

INTRODUCTION: Rising demand for gender-affirming hormone therapy mandates a need for more formalised care of transgender and gende..

Prevalence of pre-existing dysglycaemia among inpatients with acute coronary syndrome and associations with outcomes

Dinesh C Mahendran, Garry Hamilton, Jeremy Weiss, Leonid Churilov, Jeremy Lew, Kaylyn Khoo, Que Lam, Raymond Robbins, Graeme K Hart, Douglas Johnson, David L Hare, Omar Farouque, Jeffrey D Zajac, Elif I Ekinci

Journal article  |  2019  |  Diabetes Research and Clinical Practice

AIMS: We aimed to confirm the hypothesis that dysglycaemia including in the pre-diabetes range affects a majority of patients admi..

Biomechanical leg muscle function during stair ambulation in men receiving androgen deprivation therapy.

Ada S Cheung, Hans A Gray, Anthony G Schache, Rudolf Hoermann, Jarrod Bicknell, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann

Journal article  |  2019  |  The Journals of Gerontology: Series A

BACKGROUND: The role of testosterone in maintaining functional performance in older men remains uncertain. METHODS: We conducted a..

Metformin: time to review its role and safety in chronic kidney disease

Cara Tanner, Gayathiri Wang, Nancy Liu, Sofianos Andrikopoulos, Jeffrey D Zajac, Elif I Ekinci

Journal article  |  2019  |  Medical Journal of Australia

Selective Loss of Levator Ani and Leg Muscle Volumes in Men Undergoing Androgen Deprivation Therapy

Ada S Cheung, Christopher Cunningham, Dong-Kyoon Daniel Ko, Vivian Ly, Hans Gray, Rudolf Hoermann, Boyd JG Strauss, Ebrahim Bani Hassan, Gustavo Duque, Peter Ebeling, Marcus G Pandy, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2019  |  The Journal of Clinical Endocrinology & Metabolism

Routine HbA1c among hematology and oncology inpatients: Diabetes-status and hospital-outcomes

Wei-Ling Chiu, Leonid Churilov, Chee-Hau Lim, Alanna Tan, Rithin Nedumannil, Lik-Hui Lau, Jeremy Lew, Mariam Hachem, Alvin Kong, Raymond Robbins, Harvey Sutcliffe, Que Lam, Andrew Lee, Frida Djukiadmodjo, Natalie Nanayakkara, Jeffrey D Zajac, Elif I Ekinci

Journal article  |  2019  |  Diabetes Research and Clinical Practice

Older People With Type 2 Diabetes-Individualizing Management With a Specialized (OPTIMISE) Community Team: Protocol for a Safety and Feasibility Mixed Methods Study

Rajna Ogrin, Sandra Neoh, Tracy Aylen, Ralph Audehm, Leonid Churilov, Lorenna Thurgood, Georgia Major, Jeffrey Zajac, Elif Ekinci

Journal article  |  2019  |  JMIR Research Protocols

Is Thermal Imaging a Useful Predictor of the Healing Status of Diabetes-Related Foot Ulcers? A Pilot Study.

Behzad Aliahmad, Aye Nyein Tint, Sridhar Poosapadi Arjunan, Priya Rani, Dinesh Kant Kumar, Julie Miller, Jeffrey D Zajac, Gayathiri Wang, Elif Ilhan Ekinci

Journal article  |  2019  |  Journal of Diabetes Science and Technology

INTRODUCTION: In clinical practice, both area and temperature of the ulcer have been shown to be effective in tracking the healing..

The androgen receptor in the hypothalamus positively regulates hind-limb muscle mass and voluntary physical activity in adult male mice

Michele V Clarke, Patricia K Russell, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2019  |  The Journal of Steroid Biochemistry and Molecular Biology

Cross-sex hormone therapy in Australia: the prescription patterns of clinicians experienced in adult transgender healthcare

Ingrid Bretherton, Emily Thrower, Mathis Grossmann, Jeffrey D Zajac, Ada S Cheung

Journal article  |  2019  |  Internal Medicine Journal

Gender-affirming hormone therapy and the risk of sex hormone-dependent tumours in transgender individuals-A systematic review

Thomas McFarlane, Jeffrey D Zajac, Ada S Cheung

Journal article  |  2018  |  Clinical Endocrinology

Flash glucose monitoring-using technology to improve outcomes for patients with diabetes

Jeremy Weiss, Neale Cohen, Jeffrey D Zajac, Elif I Ekinci

Journal article  |  2018  |  Australian Journal of Rural Health

Using routine HbA1c measurements in stroke and the associations of dysglycaemia with stroke outcomes

Jeremy Lew, Vincent Thijs, Leonid Churilov, Geoffrey Donnan, Warwick Park, Raymond Robbins, Graeme K Hart, Christopher Bladin, Kaylyn Khoo, Lik-Hui Lau, Alanna Tan, Que Lam, Douglas Johnson, Jeffrey D Zajac, Elif Ekinci

Journal article  |  2018  |  Journal of Diabetes and its Complications

Routine use of HbA1c amongst inpatients hospitalised with decompensated heart failure and the association of dysglycaemia with outcomes

K Khoo, J Lew, P Neef, L Kearney, L Churilov, R Robbins, A Tan, M Hachem, L Owen-Jones, Q Lam, GK Hart, A Wilson, P Sumithran, D Johnson, PM Srivastava, O Farouque, LM Burrell, JD Zajac, EI Ekinci

Journal article  |  2018  |  Scientific Reports

Cortical Matrix Mineral Density Measured Noninvasively in Pre- and Postmenopausal Women and a Woman With Vitamin D-Dependent Rickets

Cherie Y Chiang, Roger Zebaze, Xiao-Fang Wang, Ali Ghasem-Zadeh, Jeffrey D Zajac, Ego Seeman

Journal article  |  2018  |  Journal of Bone and Mineral Research

Persisting adverse body composition changes 2 years after cessation of androgen deprivation therapy for localised prostate cancer

Ada S Cheung, Alistair J Tinson, Stefan Milevski, Rudolf Hoermann, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2018  |  European Journal of Endocrinology

Effect of testosterone treatment on bone remodelling markers and mineral density in obese dieting men in a randomized clinical trial

Mark Ng Tang Fui, Rudolf Hoermann, Brendan Nolan, Michelle Clarke, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2018  |  Scientific Reports

The great masquerader: Complications of severe catecholamine excess

Brendan J Nolan, Jeffrey D Zajac

Conference Proceedings  |  2018  |  CLINICAL ENDOCRINOLOGY

Decrease in number of men being commenced on androgen deprivation therapy for prostate cancer at a tertiary referral hospital over time

Jennifer Yeh, Ada S Cheung, Sandra Lin, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann

Conference Proceedings  |  2018  |  CLINICAL ENDOCRINOLOGY

Cyproterone vs spironolactone as anti-androgen therapy for transgender females receiving oestradiol therapy

Ada S Cheung, Olivia Ooi, Dahlia Davidoff, Shalem Y Leemaqz, Pauline Cundill, Nicholas Silberstein, Ingrid Bretherton, Mathis Grossmann, Jeffrey D Zajac

Conference Proceedings  |  2018  |  CLINICAL ENDOCRINOLOGY

Prevalence of secondary causes of bone loss in women treated with adjuvant endocrine therapy for breast cancer

Olivia Coleman, Sabashini K Ramchand, Belinda Yeo, Vanessa Wong, Cynthia Luk, Jeffrey D Zajac, Mathis Grossmann

Conference Proceedings  |  2018  |  CLINICAL ENDOCRINOLOGY

High-Resolution Spectral Analysis Accurately Identifies the Bacterial Signature in Infected Chronic Foot Ulcers in People With Diabetes

Sridhar Poosapadi Arjunan, Aye Nyein Tint, Behzad Aliahmad, Dinesh Kant Kumar, Ravi Shukla, Julie Miller, Jeffrey D Zajac, Gayathiri Wang, Rekha Viswanathan, Elif Ilhan Ekinci

Journal article  |  2018  |  The International Journal of Lower Extremity Wounds

The Presence of Diabetes and Higher HbA(1c) Are Independently Associated With Adverse Outcomes After Surgery

Priscilla H Yong, Laurence Weinberg, Niloufar Torkamani, Leonid Churilov, Raymond J Robbins, Ronald Ma, Rinaldo Bellomo, Que T Lam, James D Burns, Graeme K Hart, Jeremy F Lew, Johan Martensson, David Story, Andrew N Motley, Douglas Johnson, Jeffrey D Zajac, Elif I Ekinci

Journal article  |  2018  |  Diabetes Care

Clinical characteristics of trans and gender diverse individuals attending specialist endocrinology clinics

Ada S Cheung, Olivia Ooi, Dahlia Davidoff, Ingrid Bretherton, Mathis Grossmann, Jeffrey D Zajac

Conference Proceedings  |  2018  |  CLINICAL ENDOCRINOLOGY

Persistent adiposity 2 years after cessation of androgen deprivation therapy in men with prostate cancer

Stefan V Milevski, Ada S Cheung, Alistair J Tinson, Rudolf Hoermann, Jeffrey D Zajac, Mathis Grossmann

Conference Proceedings  |  2018  |  CLINICAL ENDOCRINOLOGY

Short-term effects of transdermal estradiol in men undergoing androgen deprivation therapy for prostate cancer: a randomized placebo-controlled trial

Nicholas Russell, Rudolf Hoermann, Ada S Cheung, Michael Ching, Jeffrey D Zajac, David J Handelsman, Mathis Grossmann

Journal article  |  2018  |  European Journal of Endocrinology

The androgen receptor in bone marrow progenitor cells negatively regulates fat mass

Patricia K Russell, Salvatore Mangiafico, Barbara C Fam, Michele V Clarke, Evelyn S Marin, Sofianos Andrikopoulos, Kristine M Wiren, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2018  |  Journal of Endocrinology

Sociodemographic and Clinical Characteristics of Transgender Adults in Australia.

Ada S Cheung, Olivia Ooi, Shalem Leemaqz, Pauline Cundill, Nicholas Silberstein, Ingrid Bretherton, Emily Thrower, Peter Locke, Mathis Grossmann, Jeffrey D Zajac

Journal article  |  2018  |  Transgender Health

Background: Over the last 10 years, increases in demand for transgender health care has occurred worldwide. T..

Diabetic ketoacidosis in acromegaly; a rare complication precipitated by corticosteroid use

Jeremy Weiss, Anna J Wood, Jeffrey D Zajac, Mathis Grossmann, Sofianos Andrikopoulos, Elif I Ekinci

Journal article  |  2017  |  Diabetes Research and Clinical Practice

Actin alpha cardiac muscle 1 gene expression is upregulated in the skeletal muscle of men undergoing androgen deprivation therapy for prostate cancer

Ada S Cheung, Casey de Rooy, Itamar Levinger, Kesha Rana, Michele V Clarke, Jackie M How, Andrew Garnham, Catriona McLean, Jeffrey D Zajac, Rachel A Davey, Mathis Grossmann

Journal article  |  2017  |  The Journal of Steroid Biochemistry and Molecular Biology

Androgen Action via the Androgen Receptor in Neurons Within the Brain Positively Regulates Muscle Mass in Male Mice

Rachel A Davey, Michele V Clarke, Patricia K Russell, Kesha Rana, Jane Seto, Kelly N Roeszler, Jackie MY How, Ling Yeong Chia, Kathryn North, Jeffrey D Zajac

Journal article  |  2017  |  Endocrinology

The effects of testosterone on body composition in obese men are not sustained after cessation of testosterone treatment

Mark Ng Tang Fui, Rudolf Hoermann, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2017  |  Clinical Endocrinology

Premenopausal women with early breast cancer treated with estradiol suppression have severely deteriorated bone microstructure

Sabashini K Ramchand, Ego Seeman, Xiao-Fang Wang, Ali Ghasem-Zadeh, Prudence A Francis, Evangeline J Ponnusamy, Michele S Bardin, Minh Bui, Roger Zebaze, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2017  |  Bone

Review of Evidence for Adult Diabetic Ketoacidosis Management Protocols

Tara TT Tran, Anthony Pease, Anna J Wood, Jeffrey D Zajac, Johan Martensson, Rinaldo Bellomo, Elif II Ekinci

Journal article  |  2017  |  Frontiers in Endocrinology

Using Routine Hemoglobin A1c Testing to Determine the Glycemic Status in Psychiatric Inpatients

Pratyusha Naidu, Leonid Churilov, Alvin Kong, Richard Kanaan, Henry Wong, Arielle Van Mourik, Anthony Yao, Elizabeth Cornish, Mariam Hachem, Graeme K Hart, Elizabeth Owen-Jones, Raymond Robbins, Que Lam, Katherine Samaras, Jeffrey D Zajac, Elif I Ekinci

Journal article  |  2017  |  Frontiers in Endocrinology

Symptomatic response to testosterone treatment in dieting obese men with low testosterone levels in a randomized, placebo-controlled clinical trial

M Ng Tang Fui, R Hoermann, La Prendergast, Jd Zajac, M Grossmann

Journal article  |  2017  |  International Journal of Obesity

Quality of life decrements in men with prostate cancer undergoing androgen deprivation therapy

Ada S Cheung, Casey de Rooy, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2017  |  Clinical Endocrinology

The strengths and weaknesses of evidence-based medicine

Jeffrey D Zajac

Journal article  |  2017  |  The Medical Journal of Australia

Androgen deprivation causes selective deficits in the biomechanical leg muscle function of men during walking: a prospective case-control study

Ada S Cheung, Hans Gray, Anthony G Schache, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann

Journal article  |  2017  |  Journal of Cachexia, Sarcopenia and Muscle

Using Automated HbA1c Testing to Detect Diabetes Mellitus in Orthopedic Inpatients and Its Effect on Outcomes

Elif I Ekinci, Alvin Kong, Leonid Churilov, Natalie Nanayakkara, Wei Ling Chiu, Priya Sumithran, Frida Djukiadmodjo, Erosha Premaratne, Elizabeth Owen-Jones, Graeme Kevin Hart, Raymond Robbins, Andrew Hardidge, Douglas Johnson, Scott T Baker, Jeffrey D Zajac

Journal article  |  2017  |  PLoS One

Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease.

Rania Soudy, Aarti Patel, Wen Fu, Kamaljit Kaur, David MacTavish, David Westaway, Rachel Davey, Jeffrey Zajac, Jack Jhamandas

Journal article  |  2017  |  Alzheimer's & Dementia: Translational Research & Clinical Interventions

INTRODUCTION: Amylin receptor serves as a portal for the expression of deleterious effects of amyloid β-protein (Aβ), a key pathol..

Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial

Mark Ng Tang Fui, Luke A Prendergast, Philippe Dupuis, Manjri Raval, Boyd J Strauss, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2016  |  BMC Medicine

Endocrine Society of Australia position statement on male hypogonadism (part 2): treatment and therapeutic considerations

Bu B Yeap, Mathis Grossmann, Robert I McLachlan, David J Handelsman, Gary A Wittert, Ann J Conway, Bronwyn GA Stuckey, Douglas W Lording, Carolyn A Allan, Jeffrey D Zajac, Henry G Burger

Journal article  |  2016  |  Medical Journal of Australia

Relationships between insulin resistance and frailty with body composition and testosterone in men undergoing androgen deprivation therapy for prostate cancer

Ada S Cheung, Rudolf Hoermann, Philippe Dupuis, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2016  |  European Journal of Endocrinology

Endocrine Society of Australia position statement on male hypogonadism (part 1): assessment and indications for testosterone therapy

Bu B Yeap, Mathis Grossmann, Robert I McLachlan, David J Handelsman, Gary A Wittert, Ann J Conway, Bronwyn GA Stuckey, Douglas W Lording, Carolyn A Allan, Jeffrey D Zajac, Henry G Burger

Journal article  |  2016  |  Medical Journal of Australia

The problem with modern endocrinology

Jeffrey D Zajac

Journal article  |  2016  |  The Medical Journal of Australia

Correlation of visceral adipose tissue measured by Lunar Prodigy dual X-ray absorptiometry with MRI and CT in older men

AS Cheung, C de Rooy, R Hoermann, EJ Gianatti, EJ Hamilton, G Roff, JD Zajac, M Grossmann

Journal article  |  2016  |  International Journal of Obesity

Muscle-specific androgen receptor deletion shows limited actions in myoblasts but not in myofibers in different muscles in vivo

Kesha Rana, Maria WS Chiu, Patricia K Russell, Jarrod P Skinner, Nicole KL Lee, Barbara C Fam, Jeffrey D Zajac, Helen E MacLean

Journal article  |  2016  |  Journal of Molecular Endocrinology

Bowel perforation complicating an ACTH-secreting phaeochromocytoma

Elise Flynn, Sara Baqar, Dorothy Liu, Elif I Ekinci, Stephen Farrell, Jeffrey D Zajac, Mario De Luise, Ego Seeman

Journal article  |  2016  |  Endocrinology, Diabetes and Metabolism Case Reports

Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice

Chrysovalantou E Xirouchaki, Salvatore P Mangiafico, Katherine Bate, Zheng Ruan, Amy M Huang, Bing Wilari Tedjosiswoyo, Benjamin Lamont, Wynne Pong, Jenny Favaloro, Amy R Blair, Jeffrey D Zajac, Joseph Proietto, Sofianos Andrikopoulos

Journal article  |  2016  |  Molecular Metabolism

Association of sex hormone-binding globulin and free testosterone with mortality in men with type 2 diabetes mellitus

Aye N Tint, Rudolf Hoermann, Henry Wong, Elif I Ekinci, Richard J MacIsaac, George Jerums, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2016  |  European Journal of Endocrinology

Targeting muscle signaling pathways to minimize adverse effects of androgen deprivation

Casey de Rooy, Mathis Grossmann, Jeffrey D Zajac, Ada S Cheung

Journal article  |  2016  |  Endocrine-Related Cancer

Effect of testosterone treatment on cardiac biomarkers in a randomized controlled trial of men with type 2 diabetes

Emily J Gianatti, Rudolf Hoermann, Que Lam, Philippe Dupuis, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2016  |  Clinical Endocrinology

Osteoclast TGF-beta Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation

Megan M Weivoda, Ming Ruan, Larry Pederson, Christine Hachfeld, Rachel A Davey, Jeffrey D Zajac, Jennifer J Westendorf, Sundeep Khosla, Merry Jo Oursler

Journal article  |  2016  |  Journal of Bone and Mineral Research

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

Megan M Weivoda, Ming Ruan, Christine M Hachfeld, Larry Pederson, Alan Howe, Rachel A Davey, Jeffrey D Zajac, Yasuhiro Kobayashi, Bart O Williams, Jennifer J Westendorf, Sundeep Khosla, Merry Jo Oursler

Journal article  |  2016  |  Journal of Bone and Mineral Research

Response to Wnt Signaling Pathways

Merry Jo Oursler, Jennifer J Westendorf, Megan M Weivoda, Ming Ruan, Christine M Hachfeld, Alan Howe, Rachel Davey, Jeffrey Zajac, Bart O Williams, Sundeep Khosla

Journal article  |  2015  |  Journal of Bone and Mineral Research

A Role for the Calcitonin Receptor to Limit Bone Loss During Lactation in Female Mice by Inhibiting Osteocytic Osteolysis

Michele V Clarke, Patricia K Russell, David M Findlay, Stephen Sastra, Paul H Anderson, Jarrod P Skinner, Gerald J Atkins, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2015  |  Endocrinology

The androgen receptor has no direct antiresorptive actions in mouse osteoclasts

Mieke Sinnesael, Ferran Jardi, Ludo Deboel, Michael R Laurent, Vanessa Dubois, Jeffrey D Zajac, Rachel A Davey, Geert Carmeliet, Frank Claessens, Dirk Vanderschueren

Journal article  |  2015  |  Molecular and Cellular Endocrinology

Sex steroids levels in chronic kidney disease and kidney transplant recipients: associations with disease severity and prediction of mortality

Mathis Grossmann, Rudolf Hoermann, Mark Ng Tang Fui, Jeffrey D Zajac, Franscesco L Ierino, Matthew A Roberts

Journal article  |  2015  |  Clinical Endocrinology

Androgen Receptor Action in Osteoblasts in Male Mice Is Dependent on Their Stage of Maturation

Patricia K Russell, Michele V Clarke, Karey Cheong, Paul H Anderson, Howard A Morris, Kristine M Wiren, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2015  |  Journal of Bone and Mineral Research

Inpatient HbA1c testing: a prospective observational study

Natalie Nanayakkara, Hang Nguyen, Leonid Churilov, Alvin Kong, Nyuk Pang, Graeme K Hart, Elizabeth Owen-Jones, Jennifer White, Jane Ross, Victoria Stevenson, Rinaldo Bellomo, Que Lam, Nicholas Crinis, Raymond Robbins, Doug Johnson, Scott T Baker, Jeffrey D Zajac, Elif I Ekinci

Journal article  |  2015  |  BMJ Open Diabetes Research & Care

Effect of Testosterone Treatment on Constitutional and Sexual Symptoms in Men With Type 2 Diabetes in a Randomized, Placebo-Controlled Clinical Trial

Emily J Gianatti, Philippe Dupuis, Rudolf Hoermann, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2014  |  The Journal of Clinical Endocrinology & Metabolism

Muscle and bone effects of androgen deprivation therapy: current and emerging therapies

Ada S Cheung, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2014  |  Endocrine Related Cancer

Expression of androgen receptor target genes in skeletal muscle

Kesha Rana, Nicole KL Lee, Jeffrey D Zajac, Helen E MacLean

Journal article  |  2014  |  Asian Journal of Andrology

Effect of Testosterone Treatment on Glucose Metabolism in Men With Type 2 Diabetes: A Randomized Controlled Trial

Emily J Gianatti, Philippe Dupuis, Rudolf Hoermann, Boyd J Strauss, John M Wentworth, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2014  |  Diabetes Care

Testosterone levels increase in association with recovery from acute fracture in men

AS Cheung, S Baqar, R Sia, R Hoermann, S Iuliano-Burns, TDT Vu, C Chiang, EJ Hamilton, E Gianatti, E Seeman, JD Zajac, M Grossmann

Journal article  |  2014  |  Osteoporosis International

Assessment and management of male androgen disorders: an update

Irene Chan, Mark Ng Tang Fui, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2014  |  Australian Family Physician

Human androgen deficiency: insights gained from androgen receptor knockout mouse models

Kesha Rana, Rachel A Davey, Jeffrey D Zajac

Journal article  |  2014  |  Asian Journal of Andrology

Normal phenotype in conditional androgen receptor (AR) exon 3-floxed neomycin-negative male mice

Kesha Rana, Michele V Clarke, Jeffrey D Zajac, Rachel A Davey, Helen E MacLean

Journal article  |  2014  |  Endocrine Research

IMPROVING MANAGEMENT OF LOW TRAUMA FRACTURES IN A TERTIARY HOSPITAL: THE "FRACTURE CAPTURE" PROJECT

S Iuliano, T Vu, C Chiang, E Gianatti, E Hamilton, M Grossmann, E Seeman, J Zajac

Conference Proceedings  |  2013  |  OSTEOPOROSIS INTERNATIONAL

Expression of Wnt signaling skeletal development genes in the cartilaginous fish, elephant shark (Callorhinchus milii)

Damian G D'Souza, Kesha Rana, Kristi M Milley, Helen E MacLean, Jeffrey D Zajac, Justin Bell, Sydney Brenner, Byrappa Venkatesh, Samantha J Richardson, Janine A Danks

Journal article  |  2013  |  General and Comparative Endocrinology

Obesity and age as dominant correlates of low testosterone in men irrespective of diabetes status

M Ng Tang Fui, R Hoermann, AS Cheung, EJ Gianatti, JD Zajac, M Grossmann

Journal article  |  2013  |  Andrology

Androgens and prostate cancer; pathogenesis and deprivation therapy

Mathis Grossmann, Ada S Cheung, Jeffrey D Zajac

Journal article  |  2013  |  Best Practice & Research: Clinical Endocrinology & Metabolism

Cardiovascular risk and bone loss in men undergoing androgen deprivation therapy for non-metastatic prostate cancer: implementation of standardized management guidelines

AS Cheung, D Pattison, I Bretherton, R Hoermann, D Lim Joon, E Ho, T Jenkins, EJ Hamilton, K Bate, I Chan, JD Zajac, M Grossmann

Journal article  |  2013  |  Andrology

Measuring thyroid peroxidase antibodies on the day nulliparous women present for management of miscarriage: a descriptive cohort study

Mathis Grossmann, Rudolf Hoermann, Claire Francis, Emma J Hamilton, Aye Tint, Tu'uhevaha Kaitu'u-Lino, Kent Kuswanto, Martha Lappas, Ken Sikaris, Jeffery D Zajac, Michael Permezel, Stephen Tong

Journal article  |  2013  |  Reproductive Biology and Endocrinology

Osteocalcin, Undercarboxylated Osteocalcin, and Glycemic Control in Human Subjects

Itamar Levinger, Jeffrey D Zajac, Ego Seeman

Book Chapter  |  2013

A Comparison of Precipitants and Mortality When Acute Decompensated Heart Failure Occurs in the Community and Hospital Settings

D McD Taylor, M Ng Tang Fui, AR Chung, L Gani, JD Zajac, LM Burrell

Journal article  |  2012  |  Heart, Lung and Circulation

Low testosterone levels as an independent predictor of mortality in men with chronic liver disease

Mathis Grossmann, Rudolf Hoermann, Linsey Gani, Irene Chan, Ada Cheung, Paul J Gow, Angela Li, Jeffrey D Zajac, Peter Angus

Journal article  |  2012  |  Clinical Endocrinology

Identification of gene pathways altered by deletion of the androgen receptor specifically in mineralizing osteoblasts and osteocytes in mice

Patricia K Russell, Michele V Clarke, Jarrod P Skinner, Tammy PS Pang, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2012  |  Journal of Molecular Endocrinology

Decreased body weight in young Osterix-Cre transgenic mice results in delayed cortical bone expansion and accrual

Rachel A Davey, Michele V Clarke, Stephen Sastra, Jarrod P Skinner, Cherie Chiang, Paul H Anderson, Jeffrey D Zajac

Journal article  |  2012  |  Transgenic Research

Hematological changes during androgen deprivation therapy

Mathis Grossmann, Jeffrey D Zajac

Journal article  |  2012  |  Asian Journal of Andrology

KENNEDY'S DISEASE Clinical Significance of Tandem Repeats in the Androgen Receptor

Jeffrey A Zajac, Ng Tang Fui Mark

Book Chapter  |  2012  |  Advances in Experimental Medicine and Biology

Increased adiposity in DNA binding-dependent androgen receptor knockout male mice associated with decreased voluntary activity and not insulin resistance

Kesha Rana, Barbara C Fam, Michele V Clarke, Tammy PS Pang, Jeffrey D Zajac, Helen E MacLean

Journal article  |  2011  |  American Journal of Physiology - Endocrinology and Metabolism

Management of Side Effects of Androgen Deprivation Therapy

Mathis Grossmann, Jeffrey D Zajac

Journal article  |  2011  |  Endocrinology and Metabolism Clinics of North America

Ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle and regulates myoblast proliferation

Nicole KL Lee, Jarrod PJ Skinner, Jeffrey D Zajac, Helen E MacLean

Journal article  |  2011  |  American Journal of Physiology - Endocrinology and Metabolism

Bone and metabolic health in patients with non-metastatic prostate cancer who are receiving androgen deprivation therapy

Mathis Grossmann, Emma J Hamilton, Christopher Gilfillan, Damien Bolton, Daryl Lim Joon, Jeffrey D Zajac

Journal article  |  2011  |  Medical Journal of Australia

Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy

EJ Hamilton, E Gianatti, BJ Strauss, J Wentworth, D Lim-Joon, D Bolton, JD Zajac, M Grossmann

Journal article  |  2011  |  Clinical Endocrinology

Androgen deprivation therapy in men with prostate cancer: how should the side effects be monitored and treated?

Mathis Grossmann, Jeffrey D Zajac

Journal article  |  2011  |  Clinical Endocrinology

The role of the calcitonin receptor in protecting against induced hypercalcemia is mediated via its actions in osteoclasts to inhibit bone resorption

Andrew G Turner, Francisca Tjahyono, WS Maria Chiu, Jarrod Skinner, Rebecca Sawyer, Alison J Moore, Howard A Morris, David M Findlay, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2011  |  Bone

Structural Decay of Bone Microarchitecture in Men with Prostate Cancer Treated with Androgen Deprivation Therapy

EJ Hamilton, A Ghasem-Zadeh, E Gianatti, D Lim-Joon, D Bolton, R Zebaze, E Seeman, JD Zajac, M Grossmann

Journal article  |  2010  |  Journal of Clinical Endocrinology & Metabolism

DNA-binding-dependent androgen receptor signaling contributes to gender differences and has physiological actions in males and females

Helen E MacLean, Alison J Moore, Stephen A Sastra, Howard A Morris, Ali Ghasem-Zadeh, Kesha Rana, Anna-Maree Axell, Amanda J Notini, David J Handelsman, Ego Seeman, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2010  |  Journal of Endocrinology

Testosterone and type 2 diabetes

Mathis Grossmann, Emily J Gianatti, Jeffrey D Zajac

Journal article  |  2010  |  Current Opinion in Endocrinology, Diabetes and Obesity

Medical identity fraud in the United States: could it happen here?

Jeffrey D Zajac

Journal article  |  2010  |  Medical Journal of Australia

Patients presenting with severe hypotonic hyponatremia: etiological factors, assessment, and outcomes.

Thuy Vu, Rosemary Wong, P Shane Hamblin, Jeffrey Zajac, Mathis Grossmann

Journal article  |  2009  |  Hospital Practice

BACKGROUND: Although hospital-acquired hyponatremia is well described, severe community-acquired hyponatremia has been studied les..

Sertoli Cell Androgen Receptor DNA Binding Domain Is Essential for the Completion of Spermatogenesis

Patrick Lim, Mathew Robson, Jenny Spaliviero, Kirsten J McTavish, Mark Jimenez, Jeffrey D Zajac, David J Handelsman, Charles M Allan

Journal article  |  2009  |  Endocrinology

President Obama's health care plan

Jeffrey D Zajac

Journal article  |  2009  |  Medical Journal of Australia

The high cost of drugs in the United States

Jeffrey D Zajac

Journal article  |  2009  |  Medical Journal of Australia

Mineralization and Bone Resorption Are Regulated by the Androgen Receptor in Male Mice

Cherie Chiang, Maria Chiu, Alison J Moore, Paul H Anderson, Ali Ghasem Zadeh, Julie F McManus, Cathy Ma, Ego Seeman, Thomas L Clemens, Howard A Morris, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2009  |  Journal of Bone and Mineral Research

LDL-receptor related protein five controls bone formation by inhibiting serotonin synthesis in the duodenum

VK Yadav, JH Ryu, N Suda, KF Tanaka, JA Gingrich, G Schütz, FH Glorieux, CY Chiang, JD Zajac, KL Insogna, J John Mann, R Hen, P Ducy, G Karsenty

Journal article  |  2009  |  Obstetrical & Gynecological Survey

Low testosterone and anaemia in men with type 2 diabetes

Mathis Grossmann, Sianna Panagiotopolous, Ken Sharpe, Richard J MacIsaac, Sophie Clarke, Jeffrey D Zajac, George Jerums, Merlin C Thomas

Journal article  |  2009  |  Clinical Endocrinology

Why is health care so expensive in the United States?

Jeffrey D Zajac

Journal article  |  2009  |  Medical Journal of Australia

Famllial hyperaldosteronism type 1 in pregnancy

E Hamilton, C O'Callaghan, RM O'Brien, M Stowasser, R Gordon, J Zajac, M Grossmann

Journal article  |  2009  |  Internal Medicine Journal

Women's health in the United States

Jeffrey D Zajac

Journal article  |  2009  |  Medical Journal of Australia

What Australia can learn from the US health care system

Jeffrey D Zajac

Journal article  |  2008  |  Medical Journal of Australia

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

Vijay K Yadav, Je-Hwang Ryu, Nina Suda, Kenji F Tanaka, Jay A Gingrich, Guenther Schuetz, Francis H Glorieux, Cherie Y Chiang, Jeffrey D Zajac, Karl L Insogna, J John Mann, Rene Hen, Patricia Ducy, Gerard Karsenty

Journal article  |  2008  |  Cell

Generation and analysis of an androgen-responsive myoblast cell line indicates that androgens regulate myotube protein accretion

Y Chen, NKL Lee, JD Zajac, HE MacLean

Journal article  |  2008  |  Journal of Endocrinological Investigation

Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice

Rachel A Davey, Andrew G Turner, Julie F McManus, WS Maria Chiu, Francisca Tjahyono, Alison J Moore, Gerald J Atkins, Paul H Anderson, Cathy Ma, Vaida Glatt, Helen E MacLean, Cristina Vincent, Mary Bouxsein, Howard A Morris, David M Findlay, Frey D Zajac

Journal article  |  2008  |  Journal of Bone and Mineral Research

Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice

Helen E MacLean, WS Maria Chiu, Amanda J Notini, Anna-Maree Axell, Rachel A Davey, Julie F McManus, Cathy Ma, David R Plant, Gordon S Lynch, Jeffrey D Zajac

Journal article  |  2008  |  FASEB Journal

The development of the parathyroid gland: from fish to human

Jeffrey D Zajac, Janine A Danks

Journal article  |  2008  |  Current Opinion in Nephrology and Hypertension

Severe subfertility in mice with androgen receptor inactivation in sex accessory organs but not in testis

Ulla Simanainen, Keely McNamara, Rachel A Davey, Jeffrey D Zajac, David J Handelsman

Journal article  |  2008  |  Endocrinology

Intermittent Fugu parathyroid hormone 1 (1-34) is an anabolic bone agent in young male rats and osteopenic ovariectomized rats

Julie F McManus, Rachel A Davey, Helen E MacLean, Elizabeth A Doust, WS Maria Chiu, Natalie A Sims, Mary L Bouxsein, Vaida Glatt, Jeffrey D Zajac, Janine A Danks

Journal article  |  2008  |  Bone

Low testosterone levels are common and associated with insulin resistance in men with diabetes

Mathis Grossmann, Merlin C Thomas, Sianna Panagiotopoulos, Ken Sharpe, Richard J MacIsaac, Sophie Clarke, Jeffrey D Zajac, George Jerums

Journal article  |  2008  |  Journal of Clinical Endocrinology and Metabolism

Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes

Mathis Grossmann, Merlin C Thomas, Sianna Panagiotopoulos, Ken Sharpe, Richard J MacIsaac, Sophie Clarke, Jeffrey D Zajac, George Jerums

Journal article  |  2008  |  Journal of Clinical Endocrinology & Metabolism

Outcomes for general medical inpatients with diabetes mellitus and new hyperglycaemia

Scott T Baker, Cherie Y Chiang, Jeffrey D Zajac, Leon A Bach, George Jerums, Richard J Maclsaac

Journal article  |  2008  |  Medical Journal of Australia

A floxed allele of the androgen receptor gene causes hyperandrogenization in male mice

Helen E MacLean, WS Maria Chiu, Cathy Ma, Julie F McManus, Rachel A Davey, Rhoda Cameron, Amanda J Notini, Jeffrey D Zajac

Journal article  |  2008  |  Physiological Genomics

A floxed allele of theandrogen receptorgene causes hyperandrogenization in male mice

Helen E MacLean, WS Maria Chiu, Cathy Ma, Julie F McManus, Rachel A Davey, Rhoda Cameron, Amanda J Notini, Jeffrey D Zajac

Journal article  |  2008  |  Physiological Genomics

Oestradiol-induced spermatogenesis requires a functional androgen receptor

Patrick Lim, Charles M Allan, Amanda J Notini, Anna-Maree Axell, Jennifer Spaliviero, Mark Jimenez, Rachel Davey, Julie McManus, Helen E MaClean, Jeffrey D Zajac, David J Handelsman

Journal article  |  2008  |  Reproduction, Fertility and Development

Androgen Receptor Expression and Function in Osteoclasts

A TURNER, A NOTINI, M CHIU, J HODGE, G NICHOLSON, J ZAJAC, R DAVEY

Journal article  |  2008  |  The Open Physiology Journal

Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility

KA Walters, CM Allan, M Jimenez, PR Lim, RA Davey, JD Zajac, P Illingworth, DJ Handelsman

Journal article  |  2007  |  Endocrinology

Men with Kennedy disease have a reduced risk of androgenetic alopecia

R Sinclair, KJ Greenland, S van Egmond, C Hoedemaker, A Chapman, JD Zajac

Journal article  |  2007  |  Australasian Journal of Dermatology

Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function

Ulla Simanainen, Charles M Allan, Patrick Lim, Stephen McPherson, Mark Jimenez, Jeffrey D Zajac, Rachel A Davey, David J Handelsman

Journal article  |  2007  |  Endocrinology

Osteoblast deletion of exon 3 of the androgen receptor gene results in trabecular bone loss in adult male mice

Amanda J Notini, Julie F McManus, Alison Moore, Mary Bouxsein, Mark Jimenez, WS Maria Chiu, Vaida Glatt, Barbara E Kream, David J Handelsman, Howard A Morris, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2007  |  Journal of Bone and Mineral Research

Spinobulbar Muscular Atrophy (Kennedy's Disease)

Jeffrey D Zajac, Karen J Greenland

Book Chapter  |  2007

Severe combined hyperlipidaemia and retinal lipid infiltration in a patient with Type 2 diabetes mellitus

Rachel A Davey, Niall C Tebbutt, Jenny M Favaloro, David N O'Neal, Derek Rae, Jeffrey D Zajac, James D Best

Journal article  |  2006  |  Lipids in Health and Disease

Continuous testosterone administration prevents skeletal muscle atrophy and enhances resistance to fatigue in orchidectomized male mice

Anna-Maree Axell, Helen E MacLean, David R Plant, Leah J Harcourt, Jennifer A Davis, Mark Jimenez, David J Handelsman, Gordon S Lynch, Jeffrey D Zajac

Journal article  |  2006  |  American Journal of Physiology - Endocrinology and Metabolism

Continuous testosterone administration prevents skeletal muscle atrophy and enhances resistance to fatigue in orchidectomized male mice

Anna-Maree Axell, Helen E MacLean, David R Plant, Leah J Harcourt, Jennifer A Davis, Mark Jimenez, David J Handelsman, Gordon S Lynch, Jeffrey D Zajac

Journal article  |  2006  |  American Journal of Physiology - Endocrinology and Metabolism

Effects of Amylin Deficiency on Trabecular Bone in Young Mice Are Sex-Dependent

RA Davey, AJ Moore, MWS Chiu, AJ Notini, HA Morris, JD Zajac

Journal article  |  2006  |  Calcified Tissue International

Effects of amylin deficiency on trabecular bone in young mice are sex-dependent

RA Davey, AJ Moore, MWS Chiu, AJ Notini, HA Morris, JD Zajac

Journal article  |  2006  |  Calcified Tissue International

Double-strand DNA break repair with replication slippage on two strands: A novel mechanism of deletion formation

HE MacLean, JM Favaloro, GL Warne, JD Zajac

Journal article  |  2006  |  Human Mutation

Double-strand DNA break repair with replication slippage on two strands: a novel mechanism of deletion formation

Helen E MacLean, Jenny M Favaloro, Garry L Warne, Jeffrey D Zajac

Journal article  |  2006  |  Human Mutation

Alkaline phosphatase: when to measure it and what to do next

J ZAJAC, C CHIANG

Journal article  |  2006  |  Medicine Today

Genomic actions of the androgen receptor are required for normal male sexual differentiation in a mouse model

AJ Notini, RA Davey, JF McManus, KL Bate, JD Zajac

Journal article  |  2005  |  Journal of Molecular Endocrinology

Can't cope with 'acopia'.

ID Davis, JD Zajac

Journal article  |  2005  |  Internal Medicine Journal

Androgen regulation of satellite cell function

Y Chen, JD Zajac, HE MacLean

Journal article  |  2005  |  Journal of Endocrinology

Age-dependent differences in androgen binding affinity in a family with spinal and bulbar muscular atrophy

HE MacLean, M Gonzales, KJ Greenland, GL Warne, JD Zajac

Journal article  |  2005  |  Neurological Research

A long-term outcome study of intersex conditions

G Warne, S Grover, J Hutson, A Sinclair, S Metcalfe, E Northam, J Freeman

Journal article  |  2005  |  Journal of Pediatric Endocrinology and Metabolism

A controlled, prospective study of neuropsychological outcomes post parathyroidectomy in primary hyperparathyroid patients

CY Chiang, DG Andrewes, D Anderson, M Devere, I Schweitzer, JD Zajac

Journal article  |  2005  |  Clinical Endocrinology

Can't cope with 'acopoa' - letters to the editor

ID DAVIS, JD ZAJAC

Journal article  |  2005  |  Internal Medicine Journal

Hormonal Therapies for Individuals with Intersex Conditions

Garry L Warne, Sonia Grover, Jeffrey D Zajac

Journal article  |  2005  |  Treatments in Endocrinology

Hormonal therapies for individuals with intersex conditions: protocol for use.

Garry L Warne, Sonia Grover, Jeffrey D Zajac

Journal article  |  2005  |  Treatments in Endocrinology

Hormonal therapy forms part of the treatment of every intersex condition. For some conditions, such as salt-wasting congenital adr..

Increased frequency of long androgen receptor CAG repeats in male breast cancers

HE MacLean, RW Brown, J Beilin, GL Warne, JD Zajac

Journal article  |  2004  |  Breast Cancer Research and Treatment

Alkaline phosphatase when to measure it and what to do next

JD Zajac, CY Chiang, CS Pokorny

Journal article  |  2004  |  Medicine Today

Androgen deficiency and replacement therapy in men.

Adam P Morton

Journal article  |  2004  |  Medical Journal of Australia

Transgenic mice that express Cre recombinase in osteoclasts

WSM Chiu, JF McManus, AJ Notini, AI Cassady, JD Zajac, RA Davey

Journal article  |  2004  |  Genesis

Genetically modified animal models as tools for studying bone and mineral metabolism

RA Davey, HE MacLean, JF McManus, DM Findlay, JD Zajac

Journal article  |  2004  |  Journal of Bone and Mineral Research

Endocrinology - 11: Androgen deficiency and replacement therapy in men

DJ Handelsman, JD Zajac

Journal article  |  2004  |  Medical Journal of Australia

Kennedy's disease: pathogenesis and clinical approaches

KJ Greenland, JD Zajac

Journal article  |  2004  |  Internal Medicine Journal

Novel androgen receptor gene mutations in Australian patients with complete androgen insensitivity syndrome.

Helen E MacLean, Emma MA Ball, Georgia Rekaris, Garry L Warne, Jeffrey D Zajac

Journal article  |  2004  |  Human Mutation

We have identified androgen receptor (AR) gene mutations in eight Australian subjects with complete androgen insensitivity syndrom..

Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo

R Dacquin, RA Davey, C Laplace, G Levasseur, HA Morris, SR Goldring, S Gebre-Medhin, DL Galson, JD Zajac, G Karsenty

Journal article  |  2004  |  Journal of Cell Biology

Androgen deficiency and replacement therapy in men

DJ HANDELSMAN, JD ZAJAC

Journal article  |  2004  |  Medical Journal of Australia

Application of differential display in the identification of androgen-regulated genes

KJ Greenland, G Rekaris, HE MacLean, GL Warne, JD Zajac

Journal article  |  2004  |  Endocrine Research

Polymorphic CAG repeat length in the androgen receptor gene and association with neurodegeneration in a heterozygous female carrier of Kennedy's disease

KJ Greenland, J Beilin, J Castro, PN Varghese, JD Zajac

Journal article  |  2004  |  Journal of Neurology

Threshold effects of glucose transporter-4 (GLUT4) deficiency on cardiac glucose uptake and development of hypertrophy

SJ Kaczmarczyk, S Andrikopoulos, J Favaloro, AA Domenighetti, A Dunn, M Ernst, D Grail, M Fodero-Tavoletti, CE Huggins, LM Delbridge, JD Zajac, J Proietto

Journal article  |  2003  |  Journal of Molecular Endocrinology

Endocrinology in the 21st century

JD Zajac, DJ Chisholm, B Gaut

Journal article  |  2003  |  Medical Journal of Australia

Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney

BJ Lamont, S Andrikopoulos, A Funkat, J Favaloro, JM Ye, EW Kraegen, KF Howlett, JD Zajac, J Proietto

Journal article  |  2003  |  Diabetologia

The public hospital of the future

JD Zajac

Journal article  |  2003  |  Medical Journal of Australia

Aberrant cryptic responsiveness of the pCAT (R) 3-and pGL3-promoter reporter vectors

G Giannakis, SR Edmondson, JM Favaloro, JD Zajac, KJ Greenland

Journal article  |  2003  |  Biotechniques

Identification of a parathyroid hormone in the fish Fugu rubripes

JA Danks, PMW Ho, AJ Notini, F Katsis, P Hoffmann, BE Kemp, TJ Martin, JD Zajac

Journal article  |  2003  |  Journal of Bone and Mineral Research

Endocrinology in the 21st century

JD ZAJAC, D CHISHOLM, B GAUT

Journal article  |  2003  |  Medical Journal of Australia

Biochemical measurements in osteoporosis

JD ZAJAC, P EBELING

Journal article  |  2003  |  Australian Doctor

Local secretion of parathyroid hormone-related protein by an osteoblastic osteosarcoma (UMR 106-01) cell line results in growth inhibition

GMF Pasquini, RAM Davey, PWM Ho, VP Michelangeli, V Grill, SJ Kaczmarczyk, JD Zajac

Journal article  |  2002  |  Bone

Prevention of diabetes-induced albuminuria in transgenic rats overexpressing human aldose reductase

DPK Ng, CL Hardy, WC Burns, EE Muggli, N Kerr, J McCausland, D Alcorn, TE Adams, JD Zajac, RG Larkins, ME Dunlop

Journal article  |  2002  |  Endocrine

Low-intensity pulsed ultrasound stimulates a bone-forming response in UMR-106 cells

SJ Warden, JM Favaloro, KL Bennell, JM McMeeken, KW Ng, JD Zajac, JD Wark

Journal article  |  2001  |  Biochemical and Biophysical Research Communications

A case-control study of the androgen receptor gene CAG repeat polymorphism in Australian prostate carcinoma subjects

J Beilin, L Harewood, M Frydenberg, H Mameghan, RF Martyres, SJ Farish, C Yue, DR Deam, KA Byron, JD Zajac

Journal article  |  2001  |  Cancer

Relationships with serum parathyroid hormone in old institutionalized subjects

MS Stein, L Flicker, SC Scherer, LM Paton, ML O'Brien, SC Walton, P Chick, M Di Carlantonio, JD Zajac, JD Wark

Journal article  |  2001  |  Clinical Endocrinology

Evaluation of a child with ambiguous genitalia: A practical guide to diagnosis and management

GL WARNE, JD ZAJAC

Book Chapter  |  2001

Reproductive status in long-term bone marrow transplant survivors receiving busulfan-cyclophosphamide (120 mg/kg)

AP Grigg, R McLachlan, J Zajac, J Szer

Journal article  |  2000  |  Bone Marrow Transplantation

Effect of the androgen receptor CAG repeat polymorphism on transcriptional activity: specificity in prostate and non-prostate cell lines.

J Beilin, EM Ball, JM Favaloro, JD Zajac

Journal article  |  2000  |  Journal of Molecular Endocrinology

The action of androgens is essential for the development of benign prostatic hyperplasia and carcinoma of the prostate. The androg..

Use, misuse and abuse of androgens. The Endocrine Society of Australia consensus guidelines for androgen prescribing.

AJ Conway, DJ Handelsman, DW Lording, B Stuckey, JD Zajac

Journal article  |  2000  |  Medical Journal of Australia

Androgen replacement therapy (ART) is usually life-long, and should only be started after androgen deficiency has been proven by h..

Androgen receptor gene polymorphism and prostate zonal volumes in Australian and Chinese men.

B Jin, J Beilin, J Zajac, DJ Handelsman

Journal article  |  2000  |  Journal of Andrology

Prostate diseases are age and androgen dependent. The evolution of clinically overt pathology requires decades of exposure to adul..

Falls relate to vitamin D and parathyroid hormone in an Australian nursing home and hostel

MS Stein, JD Wark, SC Scherer, SL Walton, P Chick, M Di Carlantonio, JD Zajac, L Flicker

Conference Proceedings  |  1999  |  Journal of the American Geriatrics Society

Features of syndrome X develop in transgenic rats expressing a non-insulin responsive phosphoenolpyruvate carboxykinase gene.

AW Thorburn, ME Baldwin, G Rosella, JD Zajac, S Fabris, S Song, J Proietto

Journal article  |  1999  |  Diabetologia

AIMS/HYPOTHESIS: Obesity, glucose intolerance, dyslipidaemia and hypertension are a cluster of disorders (syndrome X) affecting ma..

Disorders of sexual differentiation.

GL Warne, JD Zajac

Journal article  |  1998  |  Endocrinology and Metabolism Clinics of North America

An infant born with ambiguous genitalia requires an accurate and prompt diagnosis so that a management plan can be formulated. Thi..

Differential regulation of the parathyroid hormone-related protein gene P1 and P3 promoters by cAMP.

PJ Chilco, V Leopold, JD Zajac

Journal article  |  1998  |  Molecular and Cellular Endocrinology

The role of calcitonin, and other agonists which activate the cAMP pathway, in regulating transcription of the human parathyroid h..

Androgen insensitivity syndrome in the era of molecular genetics and the Internet: a point of view.

GL Warne, JD Zajac, HE MacLean

Journal article  |  1998  |  Journal of Pediatric Endocrinology and Metabolism

The era of molecular genetics has seen the discovery of a great deal of scientific information about the androgen receptor (AR) an..

Studies on the consequences of chronic glucose oversupply in transgenic rats overexpressing phosphoenolpyruvate carboxykinase

J Proietto, G Rosella, R Dickins, M Baldwin, J Zajac, A Thorburn

Conference Proceedings  |  1997  |  Experimental and Clinical Endocrinology & Diabetes

Germline dinucleotide mutation in codon 883 of the RET proto-oncogene in multiple endocrine neoplasia type 2B without codon 918 mutation.

O Gimm, DJ Marsh, SD Andrew, A Frilling, PL Dahia, LM Mulligan, JD Zajac, BG Robinson, C Eng

Journal article  |  1997  |  The Journal of Clinical Endocrinology & Metabolism

The autosomal dominant multiple endocrine neoplasia type 2 syndromes (MEN 2) comprise three clinically distinct entities, MEN 2A, ..

Localization of functional domains in the androgen receptor.

HE MacLean, GL Warne, JD Zajac

Journal article  |  1997  |  The Journal of Steroid Biochemistry and Molecular Biology

Functional domains of the androgen receptor (AR) have been localized through a combination of studies on naturally occurring AR ge..

X-linked recessive panhypopituitarism associated with a regional duplication in Xq25-q26.

M Lagerström-Fermér, M Sundvall, E Johnsen, GL Warne, SM Forrest, JD Zajac, A Rickards, D Ravine, U Landegren, U Pettersson

Journal article  |  1997  |  American Journal of Human Genetics

We present a linkage analysis and a clinical update on a previously reported family with X-linked recessive panhypopituitarism, no..

Intersex disorders: shedding light on male sexual differentiation beyond SRY.

HE MacLean, GL Warne, JD Zajac

Journal article  |  1997  |  Clinical Endocrinology

Male sexual differentiation involves a cascade of events initiated by the presence on the Y chromosome of the SRY gene, which caus..

A type I collagen substrate increases PTH/PTHrP receptor mRNA expression and suppresses PTHrP mRNA expression in UMR106-06 osteoblast-like cells.

S Celic, PJ Chilco, JD Zajac, TJ Martin, DM Findlay

Journal article  |  1996  |  Journal of Endocrinology

We have previously shown that the response of osteoblasts to parathyroid hormone (PTH) can be influenced at the receptor level by ..

Impaired regulation of hepatic fructose-1,6-biphosphatase in the New Zealand Obese mouse: an acquired defect.

S Andrikopoulos, G Rosella, SJ Kaczmarczyk, JD Zajac, J Proietto

Journal article  |  1996  |  Metabolism

Increased hepatic glucose production, a feature of (non-insulin-dependent diabetes mellitus [NIDDM]), is present at an early age i..

Spinal and bulbar muscular atrophy: androgen receptor dysfunction caused by a trinucleotide repeat expansion.

HE MacLean, GL Warne, JD Zajac

Journal article  |  1996  |  Journal of the Neurological Sciences

Kennedy's disease (spinal and bulbar muscular atrophy) is an X-linked form of motor neuron disease that affects adult men. The syn..

Transcriptional control and the regulation of endocrine genes.

JD Zajac, PJ Chilco

Journal article  |  1995  |  Clinical and Experimental Pharmacology and Physiology

1. Endocrine genes are regulated at a number of levels during their expression. Regulation can occur during transcription, mRNA sp..

Impaired glucose tolerance and increased weight gain in transgenic rats overexpressing a non-insulin-responsive phosphoenolpyruvate carboxykinase gene.

G Rosella, JD Zajac, L Baker, SJ Kaczmarczyk, S Andrikopoulos, TE Adams, J Proietto

Journal article  |  1995  |  Molecular Endocrinology

The effects of an overexpressed, non-insulin-responsive gluconeogenic enzyme, phosphoenolpyruvate carboxykinase (GTP) (PEPCK; EC 4..

Defects of androgen receptor function: from sex reversal to motor neurone disease.

HE MacLean, GL Warne, JD Zajac

Journal article  |  1995  |  Molecular and Cellular Endocrinology

The androgen receptor (AR) is a ligand-dependent DNA transcription factor that binds androgens which cause masculinisation of the ..

Disorders of sexual development.

JD Zajac, GL Warne

Journal article  |  1995  |  Baillière's Clinical Endocrinology and Metabolism

Over the past 6 years, the structures of four key genes involved in sexual differentiation have been identified (see Figure 2). Mu..

MODULATION OF GLUCOSE-TRANSPORT BY PARATHYROID-HORMONE AND INSULIN IN UMR-106-01, A CLONAL RAT OSTEOGENIC-SARCOMA CELL-LINE

DM THOMAS, SD ROGERS, MW SLEEMAN, GM PASQUINI, FR BRINGHURST, KW NG, JD ZAJAC, JD BEST

Journal article  |  1995  |  Journal of Molecular Endocrinology

Abnormal androgen receptor binding affinity in subjects with Kennedy's disease (spinal and bulbar muscular atrophy).

HE MacLean, WT Choi, G Rekaris, GL Warne, JD Zajac

Journal article  |  1995  |  The Journal of Clinical Endocrinology & Metabolism

We have investigated androgen-binding properties of the androgen receptor (AR) in cultured suprapubic skin fibroblasts from six su..

Androgen receptor binding studies on heterozygotes in a family with androgen insensitivity syndrome

HE MacLean, S Chu, F Joske, GL Warne, JD Zajac

Journal article  |  1995  |  Biochemical and Molecular Medicine

Impaired regulation of hepatic fructose-1,6-bisphosphatase in the New Zealand obese mouse model of NIDDM.

S Andrikopoulos, G Rosella, E Gaskin, A Thorburn, S Kaczmarczyk, JD Zajac, J Proietto

Journal article  |  1993  |  Diabetes

The New Zealand obese mouse, a model of NIDDM, is characterized by hyperglycemia, hyperinsulinemia, and hepatic and peripheral ins..

Expression of parathyroid hormone-related peptide gene in the rat hypothalamus.

RA Fraser, JD Zajac, S Harvey

Journal article  |  1993  |  Comparative Biochemistry and Physiology Part B: Comparative Biochemistry

1. Parathyroid hormone-related peptide (PTHrP), originally isolated from human malignant tumors, is present in a variety of normal..

Impaired suppression of gluconeogenesis induced by overexpression of a noninsulin-responsive phosphoenolpyruvate carboxykinase gene.

G Rosella, JD Zajac, SJ Kaczmarczyk, S Andrikopoulos, J Proietto

Journal article  |  1993  |  Molecular Endocrinology

Despite detailed knowledge of the regulation of individual steps in the gluconeogenic pathway, the relative importance of each ste..

Calcitonin increases transcription of parathyroid hormone-related protein via cAMP.

PJ Chilco, JM Gerardi, SJ Kaczmarczyk, S Chu, V Leopold, JD Zajac

Journal article  |  1993  |  Molecular and Cellular Endocrinology

Transcriptional regulation of the human parathyroid hormone-related protein (PTHrP) gene by calcitonin was examined in a lung canc..

Kennedy's disease: genetic diagnosis of an inherited form of motor neuron disease.

WT Choi, HE MacLean, S Chu, GL Warne, JD Zajac

Journal article  |  1993  |  Australian and New Zealand Journal of Medicine

Kennedy's disease (X-linked spinal and bulbar muscular atrophy) is an inherited form of motor neuron disease that may be diagnosed..

Related individuals with different androgen receptor gene deletions.

HE MacLean, S Chu, GL Warne, JD Zajac

Journal article  |  1993  |  Journal of Clinical Investigation

We have identified different members of one family affected by androgen insensitivity syndrome who have deletions of different exo..

Kennedy's disease: clinical presentation and laboratory diagnosis.

MW Faragher, WT Choi, HE MacLean, GL Warne, JD Zajac

Journal article  |  1993  |  Clinical and experimental neurology

Kennedy's disease is a form of progressive spinal and bulbar muscular atrophy of adult onset. This paper describes a case of Kenne..

AN INTRATHYROIDAL BRANCHIAL CYST - A CASE-REPORT

SW LIMTIO, R JUDSON, I BUSMANIS, JD ZAJAC

Journal article  |  1992  |  ANZ Journal of Surgery

Regulation of gene transcription and proliferation by parathyroid hormone is blocked in mutant osteoblastic cells resistant to cyclic AMP.

JD Zajac, AK Kearns, RM Skurat, HM Kronenberg, FR Bringhurst

Journal article  |  1992  |  Molecular and Cellular Endocrinology

We employed a cyclic AMP-resistant subclone of UMR 106-01 osteoblastic osteosarcoma cells (UMR 4-7) with a regulated, dominant-neg..

Multiple endocrine neoplasia syndrome--type 2b. Case report and review.

ME Schenberg, JD Zajac, S Lim-Tio, NA Collier, AM Brooks, PC Reade

Journal article  |  1992  |  International Journal of Oral and Maxillofacial Surgery

The multiple endocrine neoplasia syndromes are an association of tumours of 2 or more endocrine glands. Multiple endocrine neoplas..

Negative regulatory elements in the human parathyroid hormone gene.

T Okazaki, JD Zajac, T Igarashi, E Ogata, HM Kronenberg

Journal article  |  1991  |  Journal of Biological Chemistry

We have identified and characterized a pair of negative regulatory elements far upstream of the transcription start site of the hu..

A new treatment for acquired reactive perforating collagenosis.

MA Oziemski, VR Billson, GL Crosthwaite, J Zajac, GA Varigos

Journal article  |  1991  |  Australasian Journal of Dermatology

Acquired reactive perforating collagenosis is reported in an insulin dependent diabetic patient with renal impairment, managed suc..

Production of parathyroid hormone-related protein by a rat parathyroid cell line.

JD Zajac, J Callaghan, C Eldridge, H Diefenbach-Jagger, LJ Suva, P Hudson, JM Moseley, VP Michelangeli, G Pasquini

Journal article  |  1989  |  Molecular and Cellular Endocrinology

Parathyroid hormone-related protein (PTHrP), the peptide associated with humoral hypercalcemia of malignancy, has been identified ..

Inhibition of parathyroid hormone responsiveness in clonal osteoblastic cells expressing a mutant form of 3',5'-cyclic adenosine monophosphate-dependent protein kinase.

FR Bringhurst, JD Zajac, AS Daggett, RN Skurat, HM Kronenberg

Journal article  |  1989  |  Molecular Endocrinology

PTH activates multiple acute intracellular signals within responsive target cells, but the importance of cAMP vs. other second mes..

Sensitive radiometric assay for chloramphenicol acetyltransferase using automated HPLC.

JD Zajac, JM Gerardi, AK Kearns, FR Bringhurst

Journal article  |  1988  |  DNA

Chloramphenicol acetyltransferase (CAT) is widely used as a reporter element in studies of eukaryotic gene expression. We report a..

PARATHYROID HORMONE-RELATED PROTEIN PURIFIED FROM A HUMAN-LUNG CANCER CELL-LINE

JM MOSELEY, M KUBOTA, H DIEFENBACHJAGGER, REH WETTENHALL, BE KEMP, LJ SUVA, CP RODDA, PR EBELING, PJ HUDSON, JD ZAJAC, TJ MARTIN

Journal article  |  1987  |  Proceedings of the National Academy of Sciences

A protein with biological activities similar to parathyroid hormone (PTH) has been purified from serum-free culture medium obtaine..

Basal and stimulated release of calcitonin gene-related peptide (CGRP) in patients with medullary thyroid carcinoma.

RT Mason, A Shulkes, JD Zajac, AE Fletcher, KJ Hardy, TJ Martin

Journal article  |  1986  |  Clinical Endocrinology

Calcitonin gene-related peptide (CGRP) is a recently discovered peptide whose existence was first predicted following sequence ana..

Identification of calcitonin and calcitonin gene-related peptide messenger ribonucleic acid in medullary thyroid carcinomas by hybridization histochemistry.

JD Zajac, J Penschow, T Mason, G Tregear, J Coghlan, TJ Martin

Journal article  |  1986  |  The Journal of Clinical Endocrinology & Metabolism

Synthesis and secretion of calcitonin and calcitonin gene-related peptide (CGRP) were studied in medullary thyroid carcinomas (MTC..

Glucocorticoid treatment facilitates cyclic adenosine 3',5'-monophosphate-dependent protein kinase response in parathyroid hormone-responsive osteogenic sarcoma cells.

JD Zajac, SA Livesey, VP Michelangeli, SB Rodan, GA Rodan, TJ Martin

Journal article  |  1986  |  Endocrinology

Late passage cultures of a clonal osteogenic sarcoma line (ROS 17/2.8) failed to respond to PTH with activation of cAMP-dependent ..

Comparative double-blind trial of the effectiveness and antigenicity of semisynthetic human insulin and purified porcine insulin in newly treated diabetic subjects.

RG Larkins, J Zajac, R Saunders, A Read, JL Hopper

Journal article  |  1986  |  Australian and New Zealand Journal of Medicine

A double-blind comparative trial of the effectiveness and antigenicity of semisynthetic human insulin (Novo) and highly purified (..

Biosynthesis of calcitonin by human lung cancer cells.

JD Zajac, TJ Martin, P Hudson, H Niall, JW Jacobs

Journal article  |  1985  |  Endocrinology

The ectopic secretion of calcitonin (CT) by a wide variety of nonthyroidal human tumors has been studied by CT RIA, but little inf..

Characterization of an osteoblast-like clonal cell line which responds to both parathyroid hormone and calcitonin.

SM Forrest, KW Ng, DM Findlay, VP Michelangeli, SA Livesey, NC Partridge, JD Zajac, TJ Martin

Journal article  |  1985  |  Calcified Tissue International

The clonal cell line UMR 106, which was originally derived from a rat transplantable osteogenic sarcoma with an osteoblastic pheno..

Characteristics of selective activation of cyclic AMP-dependent protein kinase isoenzymes by calcitonin and prostaglandin E2 in human breast cancer cells.

SA Livesey, G Collier, JD Zajac, BE Kemp, TJ Martin

Journal article  |  1984  |  Biochemical Journal

The characteristics of the cyclic AMP-dependent protein kinase isoenzyme response to calcitonin stimulation have been studied in t..

Selective activation of cyclic AMP dependent protein kinase by calcitonin in a calcitonin secreting lung cancer cell line.

JD Zajac, SA Livesey, TJ Martin

Journal article  |  1984  |  Biochemical and Biophysical Research Communications

The characteristics of the cyclic AMP-dependent protein kinase isoenzyme response to calcitonin have been studied in a calcitonin-..

ADRENOMYELONEUROPATHY - CLINICAL AND BIOCHEMICAL-DIAGNOSIS

SF BERKOVIC, JD ZAJAC, DJ WARBURTON, JR MERORY, AJ FELLENBERG, A POULOS, AC POLLARD

Journal article  |  1983  |  Australian and New Zealand Journal of Medicine

Linear pharmacokinetics of theophylline following multiple doses of aminophylline in adults with obstructive airways disease

DD Thorsborne-Palmer, JD Zajac, B Jarrott, PW Trembath

Journal article  |  1982  |  Clinical and Experimental Pharmacology and Physiology