Bruce Kemp

Blocking AMPK?1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

Katyayanee Neopane, Natalie Kozlov, Florentina Negoita, Lisa Murray-Segal, Robert Brink, Ashfaqul Hoque, Ashley J Ovens, Gavin Tjin, Luke M McAloon, Dingyi Yu, Naomi XY Ling, Matthew J Sanders, Jonathan S Oakhill, John W Scott, Gregory R Steinberg, Kim Loh, Bruce E Kemp, Kei Sakamoto, Sandra Galic

Journal article  |  2022  |  CELL REPORTS

AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis and a therapeutic target for metabolic di..

Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin

Geoff Harley, Marina Katerelos, Kurt Gleich, David P de Souza, Vinod K Narayana, Bruce E Kemp, David A Power, Peter F Mount

Journal article  |  2022  |  BIOMEDICINE & PHARMACOTHERAPY

BACKGROUND: Acute kidney injury (AKI) is accompanied by dysregulation of cellular energy metabolism and accumulation of intracellu..

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

Ashley J Ovens, Yi Sing Gee, Naomi XY Ling, Dingyi Yu, Justin P Hardee, Jin D Chung, Kevin RW Ngoei, Nicholas J Waters, Nolan J Hoffman, John W Scott, Kim Loh, Katrin Spengler, Regine Heller, Michael W Parker, Gordon S Lynch, Fei Huang, Sandra Galic, Bruce E Kemp, Jonathan B Baell, Jonathan S Oakhill, et al.

Journal article  |  2022  |  BIOCHEMICAL JOURNAL

The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeo..

Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism

Brittany A Stork, Adam Dean, Andrea R Ortiz, Pradip Saha, Nagireddy Putluri, Maricarmen D Planas-Silva, Iqbal Mahmud, Kimal Rajapakshe, Cristian Coarfa, Stefan Knapp, Philip L Lorenzi, Bruce E Kemp, Benjamin E Turk, John W Scott, Anthony R Means, Brian York

Journal article  |  2022  |  MOLECULAR METABOLISM

OBJECTIVE: The liver is the primary internal metabolic organ that coordinates whole body energy homeostasis in response to feeding..

Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis

Man KS Lee, Olivia D Cooney, Xuzhu Lin, Shaktypreya Nadarajah, Dragana Dragoljevic, Kevin Huynh, Danise-Ann Onda, Sandra Galic, Peter J Meikle, Thomas Edlund, Morgan D Fullerton, Bruce E Kemp, Andrew J Murphy, Kim Loh

Journal article  |  2022  |  MOLECULAR METABOLISM

OBJECTIVES: Dysregulation of cholesterol metabolism in the liver and hematopoietic stem and progenitor cells (HSPCs) promotes athe..

Disrupting AMPK-Glycogen Binding in Mice Increases Carbohydrate Utilization and Reduces Exercise Capacity

Natalie R Janzen, Jamie Whitfield, Lisa Murray-Segal, Bruce E Kemp, John A Hawley, Nolan J Hoffman

Journal article  |  2022  |  FRONTIERS IN PHYSIOLOGY

The AMP-activated protein kinase (AMPK) is a central regulator of cellular energy balance and metabolism and binds glycogen, the p..

An AMPKa2-specific phospho-switch controls lysosomal targeting for activation

Kaitlin R Morrison, William J Smiles, Naomi XY Ling, Ashfaqul Hoque, Gabrielle Shea, Kevin RW Ngoei, Dingyi Yu, Lisa Murray-Segal, John W Scott, Sandra Galic, Bruce E Kemp, Janni Petersen, Jonathan S Oakhill

Journal article  |  2022  |  CELL REPORTS

AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) are metabolic kinases that co-ordinate ..

Cellular Bioenergetics and AMPK and TORC1 Signalling in Blood Lymphoblasts Are Biomarkers of Clinical Status in FMR1 Premutation Carriers

Danuta Z Loesch, Bruce E Kemp, Minh Q Bui, Paul R Fisher, Claire Y Allan, Oana Sanislav, Kevin RW Ngoei, Anna Atkinson, Flora Tassone, Sarah J Annesley, Elsdon Storey

Journal article  |  2021  |  FRONTIERS IN PSYCHIATRY

Fragile X Associated Tremor/Ataxia Syndrome (FXTAS) is a neurodegenerative disorder affecting carriers of premutation alleles (PM)..

AMPK activation by SC4 inhibits noradrenaline- induced lipolysis and insulin-stimulated lipogenesis in white tissue

Sheng-Ju Chuang, Manuel Johanns, Sebastien Pyr Dit Ruys, Gregory R Steinberg, Bruce E Kemp, Benoit Viollet, Mark H Rider

Journal article  |  2021  |  BIOCHEMICAL JOURNAL

The effects of small-molecule AMP-activated protein kinase (AMPK) activators in rat epididymal adipocytes were compared. SC4 was t..

Relationships between Mitochondrial Function, AMPK, and TORC1 Signaling in Lymphoblasts with Premutation Alleles of the FMR1 Gene

Paul R Fisher, Claire Y Allan, Oana Sanislav, Anna Atkinson, Kevin RW Ngoei, Bruce E Kemp, Elsdon Storey, Danuta Z Loesch, Sarah J Annesley

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The X-linked FMR1 gene contains a non-coding trinucleotide repeat in its 5' region that, in normal, healthy individuals contains 2..