Bruce Kemp

Correction: Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue.

Nusrat Hussain, Sheng-Ju Chuang, Manuel Johanns, Didier Vertommen, Gregory R Steinberg, Bruce E Kemp, Mark H Rider

Journal article  |  2020  |  Biochem J

During the production process the Western blots for pThr246 PRAS40 in Figure 6B were accidentally duplicated in Figure 6C pThr649 ..

Foam Cell Induction Activates AMPK But Uncouples Its Regulation of Autophagy and Lysosomal Homeostasis

Nicholas D LeBlond, Julia RC Nunes, Tyler KT Smith, Conor D'Dwyer, Sabrina Robichaud, Suresh Gadde, Marceline Cote, Bruce E Kemp, Mireille Ouimet, Morgan D Fullerton

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The dysregulation of macrophage lipid metabolism drives atherosclerosis. AMP-activated protein kinase (AMPK) is a master regulator..

CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

Christopher G Langendorf, Matthew T O'Brien, Kevin RW Ngoei, Luke M McAloon, Urmi Dhagat, Ashfaqul Hoque, Naomi XY Ling, Toby A Dite, Sandra Galic, Kim Loh, Michael W Parker, Jonathan S Oakhill, Bruce E Kemp, John W Scott

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The calcium-calmodulin-dependent protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and whole-body energy metabolism...

Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism

Nolan J Hoffman, Jamie Whitfield, Natalie R Janzen, Mehdi R Belhaj, Sandra Galic, Lisa Murray-Segal, William J Smiles, Naomi XY Ling, Toby A Dite, John W Scott, Jonathan S Oakhill, Robert Brink, Bruce E Kemp, John A Hawley

Journal article  |  2020  |  MOLECULAR METABOLISM

OBJECTIVE: Glycogen is a major energy reserve in liver and skeletal muscle. The master metabolic regulator AMP-activated protein k..

Meteorin-like (Metrnl), as a myokine, is a therapeutic candidate for aging skeletal muscle

JO Lee, NXY Ling, BE Kemp, HS Kim

Conference Proceedings  |  2020  |  AUSTRALASIAN JOURNAL ON AGEING

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms

Stephen L Pinkosky, John W Scott, Eric M Desjardins, Brennan K Smith, Emily A Day, Rebecca J Ford, Christopher G Langendorf, Naomi XY Ling, Tracy L Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William J Smiles, Kevin RW Ngoei, Michael W Parker, Yan Yan, Karsten Melcher, Bruce E Kemp, Jonathan S Oakhill, Gregory R Steinberg

Journal article  |  2020  |  NATURE METABOLISM

Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and s..

The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPK alpha 2

Jung Ok Lee, Won Seok Byun, Min Ju Kang, Jeong Ah Han, Jiyoung Moon, Min-Jeong Shin, Ho Jun Lee, Ji Hyung Chung, Jin-Seok Lee, Chang-Gue Son, Kwon-Ho Song, Tae Woo Kim, Eun-Soo Lee, Hong Min Kim, Choon Hee Chung, Kevin RW Ngoei, Naomi XY Ling, Jonathan S Oakhill, Sandra Galic, Lisa Murray-Segal, et al.

Journal article  |  2020  |  FEBS JOURNAL

Meteorin-like (metrnl) is a recently identified adipomyokine that beneficially affects glucose metabolism; however, its underlying..

Functional analysis of an R311C variant of Ca2 -calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder

Naomi XY Ling, Christopher G Langendorf, Ashfaqul Hoque, Sandra Galic, Kim Loh, Bruce E Kemp, Andrew L Gundlach, Jonathan S Oakhill, John W Scott

Journal article  |  2020  |  BIPOLAR DISORDERS

OBJECTIVES: Loss-of-function mutations in the gene encoding the calcium-calmodulin (Ca2+ -CaM)-dependent protein kinase kinase-2 (..

The Deletion of AMPK beta 1 Worsens Glucose Tolerance and Liver Lipid Accumulation, but Doesn't Impact the Metabolic Effects of Olanzapine in Male Mice

Hesham Shamshoum, Kristen Ashworth, Kyle Medak, Bruce Kemp, David Wright

Conference Proceedings  |  2020  |  FASEB JOURNAL

Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue

Nusrat Hussain, Sheng-Ju Chuang, Manuel Johanns, Didier Vertommen, Gregory R Steinberg, Bruce E Kemp, Mark H Rider

Journal article  |  2020  |  BIOCHEMICAL JOURNAL

We investigated acute effects of two allosteric protein kinase B (PKB) inhibitors, MK-2206 and Akti-1/2, on insulin-stimulated lip..