Bruce Kemp

AMPK beta 1 activation suppresses antipsychotic-induced hyperglycemia in mice

Hesham Shamshoum, Kyle D Medak, Logan K Townsend, Kristen E Ashworth, Natasha D Bush, Margaret K Hahn, Bruce E Kemp, David C Wright

Journal article  |  2019  |  The FASEB Journal

ATP synthase inhibitory factor 1 (IF1), a novel myokine, regulates glucose metabolism by AMPK and Akt dual pathways

Hye Jeong Lee, Jiyoung Moon, InHyeok Chung, Ji Hyung Chung, Chan Park, Jung Ok Lee, Jeong Ah Han, Min Ju Kang, Eun Hye Yoo, So-Young Kwak, Garam Jo, Wonil Park, Jonghoon Park, Kyoung Min Kim, Soo Lim, Kevin RW Ngoei, Naomi XY Ling, Jonathan S Oakhill, Sandra Galic, Lisa Murray-Segal, et al.

Journal article  |  2019  |  The FASEB Journal

ATPase inhibitory factor 1 (IF1) is an ATP synthase-interacting protein that suppresses the hydrolysis activity of ATP synthase. I..

Absence of the beta 1 subunit of AMP-activated protein kinase reduces myofibroblast infiltration of the kidneys in early diabetes

Suet-Wan Choy, Scott A Fraser, Marina Katerelos, Sandra Galic, Bruce E Kemp, Peter F Mount, David A Power

Journal article  |  2019  |  International Journal of Experimental Pathology

Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Anila K Madiraju, Yang Qiu, Rachel J Perry, Yasmeen Rahimi, Xian-Man Zhang, Dongyan Zhang, João-Paulo G Camporez, Gary W Cline, Gina M Butrico, Bruce E Kemp, Gregori Casals, Gregory R Steinberg, Daniel F Vatner, Kitt F Petersen, Gerald I Shulman

Journal article  |  2019  |  Nature Medicine

In the version of this article originally published, the VPC and VCS flux data shown in Fig. 6e,f were inadvertently duplicated fr..

Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance

Kim Loh, Shanna Tam, Lisa Murray-Segal, Kevin Huynh, Peter J Meikle, John W Scott, Bryce van Denderen, Zhiping Chen, Rohan Steel, Nicholas D LeBlond, Leah A Burkovsky, Conor O'Dwyer, Julia RC Nunes, Gregory R Steinberg, Morgan D Fullerton, Sandra Galic, Bruce E Kemp

Journal article  |  2019  |  Hepatology Communications

The Spectrum of Neurological and White Matter Changes and Premutation Status Categories of Older Male Carriers of the FMR1 Alleles Are Linked to Genetic (CGG and FMR1 mRNA) and Cellular Stress (AMPK) Markers

Danuta Z Loesch, Nicholas Trost, Minh Q Bui, Eleanor Hammersley, Sui T Lay, Sarah J Annesley, Oana Sanislav, Claire Y Allan, Flora Tassone, Zhi-Ping Chen, Kevin RW Ngoei, Bruce E Kemp, David Francis, Paul R Fisher, Elsdon Storey

Journal article  |  2018  |  Frontiers in Genetics

AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation

Sophie Lepropre, Shakeel Kautbally, Marie Octave, Audrey Ginion, Marie-Blanche Onselaer, Gregory R Steinberg, Bruce E Kemp, Alexandre Hego, Odile Wera, Sanne Brouns, Frauke Swieringa, Martin Giera, Victor M Darley-Usmar, Jerome Ambroise, Bruno Guigas, Johan Heemskerk, Luc Bertrand, Cecile Oury, Christophe Beauloye, Sandrine Horman

Journal article  |  2018  |  Blood

Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin

Mardiana Lee, Marina Katerelos, Kurt Gleich, Sandra Galic, Bruce E Kemp, Peter F Mount, David A Power

Journal article  |  2018  |  Journal of the American Society of Nephrology

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

Anila K Madiraju, Yang Qiu, Rachel J Perry, Yasmeen Rahimi, Xian-Man Zhang, Dongyan Zhang, Joao-Paulo G Camporez, Gary W Cline, Gina M Butrico, Bruce E Kemp, Gregori Casals, Gregory R Steinberg, Daniel F Vatner, Kitt F Petersen, Gerald Shulman

Journal article  |  2018  |  Nature Medicine

AMPK-ACC signaling modulates platelet phospholipids content and potentiate platelet function and thrombus formation

S Lepropre, S Kautbally, M Octave, M-B Onselaer, GR Steinberg, BE Kemp, O Wera, VM Darley-Usmar, J Ambroise, B Guigas, J Heemskerk, L Bertrand, C Oury, C Beauloye, S Horman

Conference Proceedings  |  2018  |  EUROPEAN HEART JOURNAL

Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4

Kevin RW Ngoei, Christopher G Langendorf, Naomi XY Ling, Ashfaqul Hoque, Swapna Varghese, Michelle A Camerino, Scott R Walker, Ylva E Bozikis, Toby A Dite, Ashley J Ovens, William J Smiles, Roxane Jacobs, He Huang, Michael W Parker, John W Scott, Mark H Rider, Richard C Foitzik, Bruce E Kemp, Jonathan B Baell, Jonathan S Oakhill

Journal article  |  2018  |  Cell Chemical Biology

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965

Toby A Dite, Christopher G Langendorf, Ashfaqul Hoque, Sandra Galic, Richard J Rebello, Ashley J Ovens, Lisa M Lindqvist, Kevin RW Ngoei, Naomi XY Ling, Luc Furic, Bruce E Kemp, John W Scott, Jonathan S Oakhill

Journal article  |  2018  |  Journal of Biological Chemistry

Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells

Ashfaqul Hogue, Priyadharshini Sivakumaran, Simon T Bond, Naomi XY Ling, Anne M Kong, John W Scott, Nadeeka Bandara, Damian Hernandez, Guei-Sheung Liu, Raymond CB Wong, Michael T Ryan, Derek J Hausenloy, Bruce E Kemp, Jonathan S Oakhill, Brian G Drew, Alice Pebay, Shiang Y Lim

Journal article  |  2018  |  Cell Death Discovery

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

Sandra Galic, Kim Loh, Lisa Murray-Segal, Gregory R Steinberg, Zane B Andrews, Bruce E Kemp

Journal article  |  2018  |  ELIFE

Visualizing AMPK Drug Binding Sites Through Crystallization of Full-Length Phosphorylated alpha 2 beta 1 gamma 1 Heterotrimer

Christopher G Langendorf, Jonathan S Oakhill, Bruce E Kemp

Book Chapter  |  2018  |  Methods in Molecular Biology

Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice.

Jibran A Wali, Sandra Galic, Christina Yr Tan, Esteban N Gurzov, Ann E Frazier, Timothy Connor, Jingjing Ge, Evan G Pappas, David Stroud, L Chitra Varanasi, Claudia Selck, Michael T Ryan, David R Thorburn, Bruce E Kemp, Balasubramanian Krishnamurthy, Thomas Wh Kay, Sean L McGee, Helen E Thomas

Journal article  |  2018  |  Cell death and differentiation

BCL-2 proteins are known to engage each other to determine the fate of a cell after a death stimulus. However, their evolutionary ..

Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice

Jibran A Wali, Sandra Galic, Christina YR Tan, Esteban N Gurzov, Ann E Frazier, Timothy Connor, Jingjing Ge, Evan G Pappas, David Stroud, L Chitra Varanasi, Claudia Selck, Michael T Ryan, David R Thorburn, Bruce E Kemp, Balasubramanian Krishnamurthy, Thomas WH Kay, Sean L Mcgee, Helen E Thomas

Journal article  |  2018  |  Cell Death & Differentiation

Foreword

BE Kemp

Book  |  2018

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

Toby A Dite, Naomi XY Ling, John W Scott, Ashfaqul Hoque, Sandra Galic, Benjamin L Parker, Kevin RW Ngoei, Christopher G Langendorf, Matthew T O'Brien, Mondira Kundu, Benoit Viollet, Gregory R Steinberg, Kei Sakamoto, Bruce E Kemp, Jonathan S Oakhill

Journal article  |  2017  |  Nature Communications

AMPK beta 1 reduces tumor progression and improves survival in p53 null mice

Vanessa P Houde, Sara Donzelli, Andrea Sacconi, Sandra Galic, Joanne A Hammill, Jonathan L Bramson, Robert A Foster, Theodoros Tsakiridis, Bruce E Kemp, Giuseppe Grasso, Giovanni Blandino, Paola Muti, Gregory R Steinberg

Journal article  |  2017  |  Molecular Oncology

METABOLISM Energy sensing through a sugar diphosphate

Bruce E Kemp, Jonathan S Oakhill

Journal article  |  2017  |  Nature

A default in acetyl-CoA carboxylase phosphorylation increases thrombus growth in vitro and in vivo, and in a collagen-dependent manner

S Lepropre, S Kautbally, L Bertrand, GR Steinberg, BE Kemp, A Hego, O Wera, S Brouns, F Swieringa, J Heemskerk, C Oury, C Beauloye, S Horman

Conference Proceedings  |  2017  |  EUROPEAN HEART JOURNAL

Fake Inhibitors: AMPK Activation Trumps Inhibition

Christopher G Langendorf, John W Scott, Bruce E Kemp

Journal article  |  2017  |  Cell Chemical Biology

Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2 -Calmodulin and Multisite Phosphorylation

Matthew T O'Brien, Jonathan S Oakhill, Naomi XY Ling, Christopher G Langendorf, Ashfaqul Hoque, Toby A Dite, Anthony R Means, Bruce E Kemp, John W Scott

Journal article  |  2017  |  Scientific Reports

beta-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase

Nada Ali, Naomi Ling, Srinath Krishnamurthy, Jonathan S Oakhill, John W Scott, David I Stapleton, Bruce E Kemp, Ganesh Srinivasan Anand, Paul R Gooley

Journal article  |  2016  |  Scientific Reports

Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-beta 1

Brennan K Smith, Rebecca J Ford, Eric M Desjardins, Alex E Green, Meghan C Hughes, Vanessa P Houde, Emily A Day, Katarina Marcinko, Justin D Crane, Emilio P Mottillo, Christopher GR Perry, Bruce E Kemp, Mark A Tarnopolsky, Gregory R Steinberg

Journal article  |  2016  |  Diabetes

Immortalized Parkinson's disease lymphocytes have enhanced mitochondrial respiratory activity

Sarah J Annesley, Sui T Lay, Shawn W De Piazza, Oana Sanislav, Eleanor Hammersley, Claire Y Allan, Lisa M Francione, Minh Q Bui, Zhi-Ping Chen, Kevin RW Ngoei, Flora Tassone, Bruce E Kemp, Elsdon Storey, Andrew Evans, Danuta Z Loesch, Paul R Fisher

Journal article  |  2016  |  Disease Models & Mechanisms

Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 & 2 and AMP-activated Protein Kinase in the Kidney

Michael Christensen, Jonas B Jensen, Steen Jakobsen, Niels Jessen, Jorgen Frokiaer, Bruce E Kemp, Allison L Marciszyn, Hui Li, Nria M Pastor-Soler, Kenneth R Hallows, Rikke Norregaard

Journal article  |  2016  |  Scientific Reports

An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice

Maria Rohm, Michaela Schaefer, Victor Laurent, Bilgen Ekim Uestuenel, Katharina Niopek, Carolyn Algire, Oksana Hautzinger, Tjeerd P Sijmonsma, Annika Zota, Dasa Medrikova, Natalia S Pellegata, Mikael Ryden, Agne Kulyte, Ingrid Dahlman, Peter Arner, Natasa Petrovic, Barbara Cannon, Ez-Zoubir Amri, Bruce E Kemp, Gregory R Steinberg, et al.

Journal article  |  2016  |  Nature Medicine

Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons

Jacqueline A Bayliss, Moyra B Lemus, Vanessa V Santos, Minh Deo, Jeffrey S Davies, Bruce E Kemp, John D Elsworth, Zane B Andrews

Journal article  |  2016  |  PLOS ONE

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

Emilio P Mottillo, Eric M Desjardins, Justin D Crane, Brennan K Smith, Alex E Green, Serge Ducommun, Tora I Henriksen, Irena A Rebalka, Aida Razi, Kei Sakamoto, Camilla Scheele, Bruce E Kemp, Thomas J Hawke, Joaquin Ortega, James G Granneman, Gregory R Steinberg

Journal article  |  2016  |  Cell Metabolism

Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease

Jacqueline A Bayliss, Moyra B Lemus, Romana Stark, Vanessa V Santos, Aiysha Thompson, Daniel J Rees, Sandra Galic, John D Elsworth, Bruce E Kemp, Jeffrey S Davies, Zane B Andrews

Journal article  |  2016  |  Journal of Neuroscience

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

Christopher G Langendorf, Kevin RW Ngoei, John W Scott, Naomi XY Ling, Sam MA Issa, Michael A Gorman, Michael W Parker, Kei Sakamoto, Jonathan S Oakhill, Bruce E Kemp

Journal article  |  2016  |  Nature Communications

High intensity interval training improves liver and adipose tissue insulin sensitivity

Katarina Marcinko, Sarah R Sikkema, M Constantine Samaan, Bruce E Kemp, Morgan D Fullerton, Gregory R Steinberg

Journal article  |  2015  |  Molecular Metabolism

Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder

John W Scott, Elizabeth Park, Ramona M Rodriguiz, Jonathan S Oakhill, Samah MA Issa, Matthew T O'Brien, Toby A Dite, Christopher G Langendorf, William C Wetsel, Anthony R Means, Bruce E Kemp

Journal article  |  2015  |  Scientific Reports

The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice

Katarina Marcinko, Adam L Bujak, James SV Lally, Rebecca J Ford, Tammy H Wong, Brennan K Smith, Bruce E Kemp, Yonchu Jenkins, Wei Li, Todd M Kinsella, Yasumichi Hitoshi, Gregory R Steinberg

Journal article  |  2015  |  Molecular Metabolism

Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging

Justin D Crane, Lauren G MacNeil, James S Lally, Rebecca J Ford, Adam L Bujak, Ikdip K Brar, Bruce E Kemp, Sandeep Raha, Gregory R Steinberg, Mark A Tarnopolsky

Journal article  |  2015  |  Aging Cell

AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism

Miranda M Sung, Beshay N Zordoky, Adam L Bujak, James SV Lally, David Fung, Martin E Young, Sandrine Horman, Edward J Miller, Peter E Light, Bruce E Kemp, Gregory R Steinberg, Jason RB Dyck

Journal article  |  2015  |  Cardiovascular Research

Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis

Andrew J O'Brien, Linda A Villani, Lindsay A Broadfield, Vanessa P Houde, Sandra Galic, Giovanni Blandino, Bruce E Kemp, Theodoros Tsakiridis, Paola Muti, Gregory R Steinberg

Journal article  |  2015  |  Biochemical Journal

Skeletal muscle ACC2 S212 phosphorylation is not required for the control of fatty acid oxidation during exercise

Hayley M O'Neill, James S Lally, Sandra Galic, Thomas Pulinilkunnil, Rebecca J Ford, Jason RB Dyck, Bryce J van Denderen, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2015  |  Physiological Reports

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release

John W Scott, Sandra Galic, Kate L Graham, Richard Foitzik, Naomi XY Ling, Toby A Dite, Samah MA Issa, Chris G Langendorf, Qing Ping Weng, Helen E Thomas, Thomas W Kay, Neal C Birnberg, Gregory R Steinberg, Bruce E Kemp, Jonathan S Oakhill

Journal article  |  2015  |  Chemistry & Biology

AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging

Adam L Bujak, Justin D Crane, James S Lally, Rebecca J Ford, Sally J Kang, Irena A Rebalka, Alex E Green, Bruce E Kemp, Thomas J Hawke, Jonathan D Schertzer, Gregory R Steinberg

Journal article  |  2015  |  Cell Metabolism

Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

Rebecca J Ford, Morgan D Fullerton, Stephen L Pinkosky, Emily A Day, John W Scott, Jonathan S Oakhill, Adam L Bujak, Brennan K Smith, Justin D Crane, Regje M Bluemer, Katarina Marcinko, Bruce E Kemp, Hertzel C Gerstein, Gregory R Steinberg

Journal article  |  2015  |  Biochemical Journal

Skeletal muscle AMPK is essential for the maintenance of FNDC5 expression

James SV Lally, Rebecca J Ford, Jasper Johar, Justin D Crane, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2015  |  Physiological Reports

Salicylate improves macrophage cholesterol homeostasis via activation of Ampk

Morgan D Fullerton, Rebecca J Ford, Chelsea P McGregor, Nicholas D LeBlond, Shayne A Snider, Stephanie A Stypa, Emily A Day, Sarka Lhotak, Jonathan D Schertzer, Richard C Austin, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2015  |  Journal of Lipid Research

SnRK1 from Arabidopsis thaliana is an atypical AMPK

Shane Emanuelle, Mohammed Iqbal Hossain, Isabel E Moller, Henriette L Pedersen, Allison ML van de Meene, Monika S Doblin, Ann Koay, Jonathan S Oakhill, John W Scott, William GT Willats, Bruce E Kemp, Antony Bacic, Paul R Gooley, David I Stapleton

Journal article  |  2015  |  The Plant Journal

Choreography of AMPK activation

Christopher G Langendorf, Bruce E Kemp

Journal article  |  2015  |  Cell Research

AMPK-Dependent Inhibitory Phosphorylation of ACC Is Not Essential for Maintaining Myocardial Fatty Acid Oxidation

Beshay NM Zordoky, Jeevan Nagendran, Thomas Pulinilkunnil, Petra C Kienesberger, Grant Masson, Terri J Waller, Bruce E Kemp, Gregory R Steinberg, Jason RB Dyck

Journal article  |  2014  |  Circulation Research

AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice

Hayley M O'Neill, James S Lally, Sandra Galic, Melissa Thomas, Paymon D Azizi, Morgan D Fullerton, Brennan K Smith, Thomas Pulinilkunnil, Zhiping Chen, M Constantine Samaan, Sebastian B Jorgensen, Jason RB Dyck, Graham P Holloway, Thomas J Hawke, Bryce J van Denderen, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2014  |  Diabetologia

Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress

Sean L McGee, Courtney Swinton, Shona Morrison, Vidhi Gaur, Duncan E Campbell, Sebastian B Jorgensen, Bruce E Kemp, Keith Baar, Gregory R Steinberg, M Hargreaves

Journal article  |  2014  |  The FASEB Journal

Mechanism of Action of Compound-13: An alpha 1-Selective Small Molecule Activator of AMPK

Roger W Hunter, Marc Foretz, Laurent Bultot, Morgan D Fullerton, Maria Deak, Fiona A Ross, Simon A Hawley, Natalia Shpiro, Benoit Viollet, Denis Barron, Bruce E Kemp, Gregory R Steinberg, D Grahame Hardie, Kei Sakamoto

Journal article  |  2014  |  Chemistry & Biology

Reduced skeletal muscle AMPK and mitochondrial markers do not promote age-induced insulin resistance

Adam L Bujak, Regje ME Bluemer, Katarina Marcinko, Morgan D Fullerton, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2014  |  Journal of Applied Physiology

Novel mechanisms of Na retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK

Matthew Davies, Scott A Fraser, Sandra Galic, Suet-Wan Choy, Marina Katerelos, Kurt Gleich, Bruce E Kemp, Peter F Mount, David A Power

Journal article  |  2014  |  American Journal of Physiology: Renal Physiology

PPAR delta activation attenuates hepatic steatosis in Ldlr(-/-) mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

Lazar A Bojic, Dawn E Telford, Morgan D Fullerton, Rebecca J Ford, Brian G Sutherland, Jane Y Edwards, Cynthia G Sawyez, Robert Gros, Bruce E Kemp, Gregory R Steinberg, Murray W Huff

Journal article  |  2014  |  Journal of Lipid Research

Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling

John W Scott, Naomi Ling, Samah MA Issa, Toby A Dite, Matthew T O'Brien, Zhi-Ping Chen, Sandra Galic, Christopher G Langendorf, Gregory R Steinberg, Bruce E Kemp, Jonathan S Oakhill

Journal article  |  2014  |  Chemistry & Biology

Muscle-specific AMPK beta 1 beta 2-null mice display a myopathy due to loss of capillary density in nonpostural muscles

Melissa M Thomas, David C Wang, Donna M D'Souza, Matthew P Krause, Andrew S Layne, David S Criswell, Hayley M O'Neill, Michael K Connor, Judy E Anderson, Bruce E Kemp, Gregory R Steinberg, Thomas J Hawke

Journal article  |  2014  |  The FASEB Journal

Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

Serge Ducommun, Rebecca J Ford, Laurent Bultot, Maria Deak, Luc Bertrand, Bruce E Kemp, Gregory R Steinberg, Kei Sakamoto

Journal article  |  2014  |  American Journal of Physiology-Endocrinology and Metabolism

Evidence for the Role of AMPK in Regulating PGC-1 Alpha Expression and Mitochondrial Proteins in Mouse Epididymal Adipose Tissue

Zhongxiao Wan, Jared Root-Mccaig, Laura Castellani, Bruce E Kemp, Gregory R Steinberg, David C Wright

Journal article  |  2014  |  Obesity

ATP sensitive bi-quinoline activator of the AMP-activated protein kinase

John W Scott, Jonathan S Oakhill, Naomi XY Ling, Christopher G Langendorf, Richard C Foitzik, Bruce E Kemp, Olaf-Georg Issinger

Journal article  |  2014  |  Biochemical and Biophysical Research Communications

Mutant TDP-43 Deregulates AMPK Activation by PP2A in ALS Models

ND Perera, RK Sheean, JW Scott, BE Kemp, MK Horne, BJ Turner

Journal article  |  2014  |  PLoS ONE

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Morgan D Fullerton, Sandra Galic, Katarina Marcinko, Sarah Sikkema, Thomas Pulinilkunnil, Zhi-Ping Chen, Hayley M O'Neill, Rebecca J Ford, Rengasamy Palanivel, Matthew O'Brien, D Grahame Hardie, S Lance Macaulay, Jonathan D Schertzer, Jason RB Dyck, Bryce J van Denderen, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2013  |  Nature Medicine

AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1

Scott A Fraser, Suet-Wan Choy, Nuria M Pastor-Soler, Hui Li, Matthew RP Davies, Natasha Cook, Marina Katerelos, Peter F Mount, Kurt Gleich, Jennifer L McRae, Karen M Dwyer, Bryce JW van Denderen, Kenneth R Hallows, Bruce E Kemp, David A Power

Journal article  |  2013  |  American Journal of Physiology: Renal Physiology

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

Simon A Hawley, Morgan D Fullerton, Fiona A Ross, Jonathan D Schertzer, Cyrille Chevtzoff, Katherine J Walker, Mark W Peggie, Darya Zibrova, Kevin A Green, Kirsty J Mustard, Bruce E Kemp, Kei Sakamoto, Gregory R Steinberg, D Grahame Hardie

Journal article  |  2012  |  Science

Pro-GRP-Derived Peptides Are Expressed in Colorectal Cancer Cells and Tumors and Are Biologically Active in Vivo

Oneel Patel, Daniel Clyde, Mike Chang, Marianne S Nordlund, Rohan Steel, Bruce E Kemp, D Mark Pritchard, Arthur Shulkes, Graham S Baldwin

Journal article  |  2012  |  Endocrinology

AMPK functions as an adenylate charge-regulated protein kinase

Jonathan S Oakhill, John W Scott, Bruce E Kemp

Journal article  |  2012  |  Trends in Endocrinology and Metabolism

The Outcome of Renal Ischemia-Reperfusion Injury Is Unchanged in AMPK-beta 1 Deficient Mice

Peter F Mount, Kurt Gleich, Shanna Tam, Scott A Fraser, Suet-Wan Choy, Karen M Dwyer, Bo Lu, Bryce Van denderen, Guenter Fingerle-Rowson, Richard Bucala, Bruce E Kemp, David A Power

Journal article  |  2012  |  PLoS One

Pro-GRP-Derived Peptides Are Expressed in Colorectal Cancer Cells and Tumors and Are Biologically Active in Vivo

undefined Patel, undefined Clyde, undefined Chang, undefined Nordlund, undefined Steel, BE Kemp, undefined Pritchard, undefined Shulkes, undefined Baldwin

Journal article  |  2012  |  Endocrinology

Hematopoietic AMPK beta 1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

Sandra Galic, Morgan D Fullerton, Jonathan D Schertzer, Sarah Sikkema, Katarina Marcinko, Carl R Walkley, David Izon, Jane Honeyman, Zhi-Ping Chen, Bryce J van Denderen, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2011  |  Journal of Clinical Investigation

AMP-activated protein kinase (AMPK) beta 1 beta 2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise

Hayley M O'Neill, Stine J Maarbjerg, Justin D Crane, Jacob Jeppesen, Sebastian B Jorgensen, Jonathan D Schertzer, Olga Shyroka, Bente Kiens, Bryce J van Denderen, Mark A Tarnopolsky, Bruce E Kemp, Erik A Richter, Gregory R Steinberg

Journal article  |  2011  |  Proceedings of the National Academy of Sciences of the United States of America

Ca2 /Calmodulin-dependent Protein Kinase Kinase beta Is Regulated by Multisite Phosphorylation

Michelle F Green, John W Scott, Rohan Steel, Jonathan S Oakhill, Bruce E Kemp, Anthony R Means

Journal article  |  2011  |  Journal of Biological Chemistry

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

Jonathan S Oakhill, Rohan Steel, Zhi-Ping Chen, John W Scott, Naomi Ling, Shanna Tam, Bruce E Kemp

Journal article  |  2011  |  Science

Inhibition of Kir2.1 (KCNJ2) by the AMP-activated protein kinase

Ioana Alesutan, Carlos Munoz, Mentor Sopjani, Miribane Dermaku-Sopjani, Diana Michael, Scott Fraser, Bruce E Kemp, Guiscard Seebohm, Michael Foeller, Florian Lang

Journal article  |  2011  |  Biochemical and Biophysical Research Communications

Inhibition of Connexin 26 by the AMP-Activated Protein Kinase

Ioana Alesutan, Mentor Sopjani, Carlos Munoz, Scott Fraser, Bruce E Kemp, Michael Foeller, Florian Lang

Journal article  |  2011  |  Journal of Membrane Biology

Inhibition of the heterotetrameric K channel KCNQ1/KCNE1 by the AMP-activated protein kinase

Ioana Alesutan, Michael Foeller, Mentor Sopjani, Miribane Dermaku-Sopjani, Christine Zelenak, Henning Froehlich, Ana Velic, Scott Fraser, Bruce E Kemp, Guiscard Seebohm, Harald Voelkl, Florian Lang

Journal article  |  2011  |  Molecular Membrane Biology

Whole Body Deletion of AMP-activated Protein Kinase beta 2 Reduces Muscle AMPK Activity and Exercise Capacity

Gregory R Steinberg, Hayley M O'Neill, Nicolas L Dzamko, Sandra Galic, Tim Naim, Rene Koopman, Sebastian B Jorgensen, Jane Honeyman, Kimberly Hewitt, Zhi-Ping Chen, Jonathan D Schertzer, John W Scott, Frank Koentgen, Gordon S Lynch, Matthew J Watt, Bryce JW van denderen, Duncan J Campbell, Bruce E Kemp

Journal article  |  2010  |  Journal of Biological Chemistry

beta-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

Jonathan S Oakhill, Zhi-Ping Chen, John W Scott, Rohan Steel, Laura A Castelli, Naomi Ling, S Lance Macaulay, Bruce E Kemp

Journal article  |  2010  |  Proceedings of the National Academy of Sciences of the United States of America

Down-regulation of Na plus -coupled glutamate transporter EAAT3 and EAAT4 by AMP-activated protein kinase

Mentor Sopjani, Ioana Alesutan, Miribane Dermaku-Sopjani, Scott Fraser, Bruce E Kemp, Michael Foeller, Florian Lang

Journal article  |  2010  |  Journal of Neurochemistry

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

Adem Kalender, Anand Selvaraj, So Young Kim, Pawan Gulati, Sophie Brule, Benoit Viollet, Bruce E Kemp, Nabeel Bardeesy, Patrick Dennis, John J Schlager, Andre Marette, Sara C Kozma, George Thomas

Journal article  |  2010  |  Cell Metabolism

Regulation of Na -coupled glucose carrier SGLT1 by AMP-activated protein kinase

Mentor Sopjani, Shefalee K Bhavsar, Scott Fraser, Bruce E Kemp, Michael Foeller, Florian Lang

Journal article  |  2010  |  Molecular Membrane Biology

Isolation, identification and biological activity of gastrin-releasing peptide 1-46 (oGRP(1-46)), the primary GRP gene-derived peptide product of the pregnant ovine endometrium

AS Giraud, C Dumesny, JC Whitley, LM Parker, I Jennings, B Kemp, TW Moody, V Sancho, RT Jensen, A Shulkes

Journal article  |  2010  |  Peptides

AMPK beta 1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

Nicolas Dzamko, Bryce JW van Denderen, Andrea L Hevener, Sebastian Beck Jorgensen, Jane Honeyman, Sandra Galic, Zhi-Ping Chen, Matthew J Watt, Duncan J Campbell, Gregory R Steinberg, Bruce E Kemp

Journal article  |  2010  |  Journal of Biological Chemistry

Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function

Julian MW Quinn, Shanna Tam, Natalie A Sims, Hasnawati Saleh, Narelle E McGregor, Ingrid J Poulton, John W Scott, Matthew T Gillespie, Bruce E Kemp, BJW van Denderen

Journal article  |  2010  |  FASEB Journal

Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase

Nicholas A Veldhuis, Valentina A Valova, Ann P Gaeth, Nickless Palstra, Katherine M Hannan, Belinda J Michell, Leonard E Kelly, Ian Jennings, Bruce E Kemp, Richard B Pearson, Phillip J Robinson, James Camakaris

Journal article  |  2009  |  International Journal of Biochemistry and Cell Biology

Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity

S Beck Jorgensen, HM O'Neill, K Hewitt, BE Kemp, GR Steinberg

Journal article  |  2009  |  Diabetologia

Impaired Skeletal Muscle beta-Adrenergic Activation and Lipolysis Are Associated with Whole-Body Insulin Resistance in Rats Bred for Low Intrinsic Exercise Capacity

Sarah J Lessard, Donato A Rivas, Zhi-Ping Chen, Bryce J van denderen, Matthew J Watt, Lauren G Koch, Steven L Britton, Bruce E Kemp, John A Hawley

Journal article  |  2009  |  Endocrinology

Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation

Sebastian Beck Jorgensen, Jane Honeyman, Jonathan S Oakhill, Daniel Fazakerley, Jacqueline Stoeckli, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2009  |  American Journal of Physiology - Endocrinology and Metabolism

Examination of 'lipotoxicity' in skeletal muscle of high-fat fed and ob/ob mice

SM Turpin, JG Ryall, R Southgate, I Darby, AL Hevener, MA Febbraio, BE Kemp, GS Lynch, MJ Watt

Journal article  |  2009  |  Journal of Physiology

Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase-Dependent Pathway That Is Impaired With Obesity

Gregory R Steinberg, Matthew J Watt, Matthias Ernst, Morris J Birnbaum, Bruce E Kemp, Sebastian Beck Jorgensen

Journal article  |  2009  |  Diabetes

AMPK-independent pathways regulate skeletal muscle fatty acid oxidation

Nicolas Dzamko, Jonathan D Schertzer, James G Ryall, Rohan Steel, S Lance Macaulay, Sheena Wee, Zhi-Ping Chen, Belinda J Michell, Jonathan S Oakhill, Matthew J Watt, Sebastian Beck Jorgensen, Gordon S Lynch, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2008  |  Journal of Physiology

Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase beta 1-Containing Complexes

John W Scott, Bryce JW van Denderen, Sebastian B Jorgensen, Jane E Honeyman, Gregory R Steinberg, Jonathan S Oakhill, Tristan J Iseli, Ann Koay, Paul R Gooley, David Stapleton, Bruce E Kemp

Journal article  |  2008  |  Chemistry & Biology

Differential attenuation of AMPK activation during acute exercise following exercise training or AICAR treatment

GK McConell, A Manimmanakorn, RS Lee-Young, BE Kemp, KC Linden, GD Wadley

Journal article  |  2008  |  Journal of Applied Physiology

Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans

Wee Kian Yeo, Sarah J Lessard, Zhi-Ping Chen, Andrew P Garnham, Louise M Burke, Donato A Rivas, Bruce E Kemp, John A Hawley

Journal article  |  2008  |  Journal of Applied Physiology

Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK

Peter F Mount, Natalie Lane, Sudharsan Venkatesan, Gregory R Steinberg, Scott A Fraser, Bruce E Kemp, David A Power

Journal article  |  2008  |  Atherosclerosis

Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPAR alpha and UCP2 expression in rats

Anna G Holmes, Jose L Mesa, Bronwyn A Neill, Jason Chung, Andrew L Carey, Gregory R Steinberg, Bruce E Kemp, Robert J Southgate, Graeme I Lancaster, Clinton R Bruce, Matthew J Watt, Mark A Febbraio

Journal article  |  2008  |  Journal of Endocrinology

Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites

Neil FW Saunders, Ross I Brinkworth, Thomas Huber, Bruce E Kemp, Bostjan Kobe

Journal article  |  2008  |  BMC Bioinformatics

Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness (Retracted article. See vol. 24, pg. 1308, 2010)

Matthew J Watt, Bryce JW van Denderen, Laura A Castelli, Clinton R Bruce, Andrew J Hoy, Edward W Kraegen, Lance Macaulay, Bruce E Kemp

Journal article  |  2008  |  Molecular Endocrinology

Metabolic remodeling in adipocytes promotes ciliary neurotrophic factor-mediated fat loss in obesity

Seamus Crowe, Sarah M Turpin, Francine Ke, Bruce E Kemp, Matthew J Watt

Journal article  |  2008  |  Endocrinology

Increased glycogen stores due to gamma-AMPK overexpression protects against ischemia and reperfusion damage

Michal Ofir, Michael Arad, Eyal Porat, Dov Freimark, Yelena Chepurko, Bernardo A Vidne, Christine E Seidman, Jonathan G Seidman, Bruce E Kemp, Edith Hochhauser

Journal article  |  2008  |  Biochemical Pharmacology

AMP-activated protein kinase subunit interactions - beta 1 :gamma 1 association requires beta 1 Thr-263 and Tyr-267

Tristan J Iseli, Jonathan S Oakhill, Michael F Bailey, Sheena Wee, Mark Walter, Bryce J van Denderen, Laura A Castelli, Frosa Katsis, Lee A Witters, David Stapleton, S Lance Macaulay, Belinda J Michell, Bruce E Kemp

Journal article  |  2008  |  Journal of Biological Chemistry

Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non-small cell lung cancer cells

Regan M Memmott, Joell J Gills, Melinda Hollingshead, Margaret C Powers, Zhiping Chen, Bruce Kemp, Alan Kozikowski, Phillip A Dennis

Journal article  |  2008  |  Cancer Research

Adipocyte triglyceride lipase expression in human obesity

Gregory R Steinberg, Bruce E Kemp, Matthew J Watt

Journal article  |  2007  |  American Journal of Physiology - Endocrinology and Metabolism

AMPK structure and regulation from three angles

Bruce E Kemp, Jonathan S Akhill, John W Scott

Journal article  |  2007  |  Structure

Adiponectin: Starving for attention

Gregory R Steinberg, Bruce E Kemp

Journal article  |  2007  |  Cell Metabolism

Regulation of the renal-specific Na -K -2Cl(-) co-transporter NKCC2 by AMP-activated protein kinase (AMPK)

Scott A Fraser, Ignacio Gimenez, Natasha Cook, Ian Jennings, Marina Katerelos, Frosa Katsis, Vicki Levidiotis, Bruce E Kemp, David A Power

Journal article  |  2007  |  Biochemical Journal

Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance

Sarah J Lessard, Donato A Rivas, Zhi-Ping Chen, Arend Bonen, Mark A Febbraio, Donald W Reeder, Bruce E Kemp, Ben B Yaspelkis, John A Hawley

Journal article  |  2007  |  Diabetes

Low-density lipoprotein particles and risk of intracerebral haemorrhage in subjects with cerebrovascular disease

Duncan J Campbell, Bruce C Neal, John R Chalmers, Samuel A Colman, Alicia J Jenkins, Bruce E Kemp, Anushka Patel, Stephen W MacMahon, Mark Woodward

Journal article  |  2007  |  European Journal of Cardiovascular Prevention & Rehabilitation

Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation

Laura Barre, Christine Richardson, Michael F Hirshman, Joseph Brozinick, Steven Fiering, Bruce E Kemp, Laurie J Goodyear, Lee A Witters

Journal article  |  2007  |  American Journal of Physiology - Endocrinology and Metabolism

Perindopril-based blood pressure-lowering therapy reduces amino-terminal-pro-B-type natriuretic peptide in individuals with cerebrovascular disease

Duncan J Campbell, Mark Woodward, John P Chalmers, Samuel A Colman, Alicia J Jenkins, Bruce E Kemp, Bruce C Neal, Anushka Patel, Stephen W MacMahon

Journal article  |  2007  |  Journal of Hypertension

AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein

Constanze Blume, Peter M Benz, Ulrich Walter, Joohun Ha, Bruce E Kemp, Thomas Renne

Journal article  |  2007  |  Journal of Biological Chemistry

Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation

Peter F Mount, Bruce E Kemp, David A Power

Journal article  |  2007  |  Journal of Molecular and Cellular Cardiology

Leptin stimulation of COXIV is impaired in obese skeletal muscle myotubes

AJ McAinch, GR Steinberg, J Mollica, PE O'Brien, JB Dixon, BE Kemp, D Cameron-Smith

Journal article  |  2007  |  Obesity Research & Clinical Practice

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

Gregory R Steinberg, Belinda J Michell, Bryce JW van Denderen, Matthew J Watt, Andrew L Carey, Barbara C Fam, Sofianos Andrikopoulos, Joseph Proietto, Cem Z Gorgun, David Carling, Gokhan S Hotamisligil, Mark A Febbraio, Thomas W Kay, Bruce E Kemp

Journal article  |  2006  |  Cell Metabolism

Differential regulation of adiponectin receptor gene expression by adiponectin and leptin in myotubes derived from obese and diabetic individuals

Andrew J McAinch, Gregory R Steinberg, Janelle Mollica, Paul E O'Brien, John B Dixon, S Lance Macaulay, Bruce E Kemp, David Cameron-Smith

Journal article  |  2006  |  Obesity

Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion

Michael Christopher, Christian Rantzau, Zhi-Ping Chen, Rodney Snow, Bruce Kemp, Frank P Alford

Journal article  |  2006  |  American Journal of Physiology - Endocrinology and Metabolism

Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats

Ji-Ming Ye, Nick Dzamko, Andrew J Hoy, Mguel A Iglesias, Bruce Kemp, Edward Kraegen

Journal article  |  2006  |  Diabetes

Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise

Jason L Talanian, Rebecca J Tunstall, Matthew J Watt, Mylinh Duong, Christopher GR Perry, Gregory R Steinberg, Bruce E Kemp, George JF Heigenhauser, Lawrence L Spriet

Journal article  |  2006  |  American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase

Andrew L Carey, Gregory R Steinberg, S Lance Macaulay, Walter G Thomas, Anna G Holmes, Georg Ramm, Oja Prelovsek, Cordula Hohnen-Behrens, Matthew J Watt, David E James, Bruce E Kemp, Bente K Pedersen, Mark A Febbraio

Journal article  |  2006  |  Diabetes

Carbohydrate ingestion does not alter skeletal muscle AMPK signaling during exercise in humans

Robert S Lee-Young, Matthew J Palmer, Kelly C Linden, Kieran LePlastrier, Benedict J Canny, Mark Hargreaves, Glenn D Wadley, Bruce E Kemp, Glenn K McConell

Journal article  |  2006  |  American Journal of Physiology - Endocrinology and Metabolism

The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans

Gregory R Steinberg, Andrew J McAinch, Michael B Chen, Paul E O'Brien, John B Dixon, David Cameron-Smith, Bruce E Kemp

Journal article  |  2006  |  Journal of Clinical Endocrinology & Metabolism

Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice

Gregory R Steinberg, Matthew J Watt, Barbara C Fam, Joseph Proietto, Sofianos Andrikopoulos, Andrew M Allen, Mark A Febbraio, Bruce E Kemp

Journal article  |  2006  |  Endocrinology

Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes

Matthew J Watt, Gregory R Steinberg, Zhi-Ping Chen, Bruce E Kemp, Mark A Febbraio

Journal article  |  2006  |  Journal of Physiology

AMP-activated protein kinase - the fat controller of the energy railroad

Gregory R Steinberg, S Lance Macaulay, Mark A Febbraio, Bruce E Kemp

Journal article  |  2006  |  Canadian Journal of Physiology and Pharmacology

Reduced glycogen availability is associated with increased AMPK alpha 2 activity, nuclear AMPK alpha 2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle

Gregory R Steinberg, Matthew J Watt, Sean L McGee, Stanley Chan, Mark Hargreaves, Mark A Febbraio, David Stapleton, Bruce E Kemp

Journal article  |  2006  |  Applied Physiology, Nutrition and Metabolism

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK

Matthew J Watt, Nicolas Dzamko, Walter G Thomas, Stefan Rose-John, Matthias Ernst, David Carling, Bruce E Kemp, Mark A Febbraio, Gregory R Steinberg

Journal article  |  2006  |  Nature Medicine

Differential calcineurin signalling activity and regeneration efficacy in diaphragm and limb muscles of dystrophic mdx mice

Nicole Stupka, Belinda J Michell, Bruce E Kemp, Gordon S Lynch

Journal article  |  2006  |  Neuromuscular Disorders

Effect of exercise intensity and hypoxia on skeletal muscle AMPK signaling and substrate metabolism in humans

GD Wadley, RS Lee-Young, BJ Canny, C Wasuntarawat, ZP Chen, M Hargreaves, BE Kemp, GK McConell

Journal article  |  2006  |  American Journal of Physiology - Endocrinology and Metabolism

Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue

MJ Watt, AG Holmes, SK Pinnamaneni, AP Garnham, GR Steinberg, BE Kemp, MA Febbraio

Journal article  |  2006  |  American Journal of Physiology - Endocrinology and Metabolism

Chronic rosiglitazone treatment restores AMPK alpha 2 activity in insulin-resistant rat skeletal muscle

SJ Lessard, ZP Chen, MJ Watt, M Hashem, JJ Reid, MA Febbraio, BE Kemp, JA Hawley

Journal article  |  2006  |  American Journal of Physiology - Endocrinology and Metabolism

Phosphorylation of neuronal and endothelial nitric oxide synthase in the kidney with high and low salt diets

Peter F Mount, Scott A Fraser, Yasuo Watanabe, Natalie Lane, Frosa Katsis, Zhi-Ping Chen, Bruce E Kemp, David A Power

Journal article  |  2006  |  Nephron Experimental Nephrology

Soluble vascular cell adhesion molecule 1 and N-terminal Pro-B-type natriuretic peptide in predicting ischemic stroke in patients with cerebrovascular disease

DJ Campbell, M Woodward, JP Chalmers, SA Colman, AJ Jenkins, BE Kemp, BC Neal, A Patel, SW MacMahon

Journal article  |  2006  |  Archives of Neurology

Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser(1177)

PF Mount, RE Hill, SA Fraser, V Levidiotis, F Katsis, BE Kemp, DA Power

Journal article  |  2005  |  American Journal of Physiology: Renal Physiology

Src kinase activates endothelial nitric-oxide synthase by phosphorylating Tyr-83

D Fulton, JE Church, L Ruan, CY Li, SG Sood, BE Kemp, IG Jennings, RC Venema

Journal article  |  2005  |  Journal of Biological Chemistry

Short-term exercise training in humans reduces AMPK signalling during prolonged exercise independent of muscle glycogen

GK McConell, RS Lee-Young, ZP Chen, NK Stepto, NN Huynh, TJ Stephens, BJ Canny, BE Kemp

Journal article  |  2005  |  Journal of Physiology

Associations of inflammatory and hemostatic variables with the risk of recurrent stroke

M Woodward, GDO Lowe, DJ Campbell, S Colman, A Rumley, J Chalmers, BC Neal, A Patel, AJ Jenkins, BE Kemp, SW MacMahon

Journal article  |  2005  |  Stroke

Structural basis for glycogen recognition by AMP-activated protein kinase

G Polekhina, A Gupta, BJW van Denderen, SC Fell, BE Kemp, D Stapleton, MW Parker

Journal article  |  2005  |  Structure

Socs1 deficiency enhances hepatic insulin signaling

E Jamieson, MMW Chong, GR Steinberg, V Jovanovska, BC Fam, DVR Bullen, Y Chen, BE Kemp, J Proietto, TWH Kay, S Andrikopoulos

Journal article  |  2005  |  Journal of Biological Chemistry

The Ca2 /calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases

RL Hurley, KA Anderson, JM Franzone, BE Kemp, AR Means, LA Witters

Journal article  |  2005  |  Journal of Biological Chemistry

Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization

MT Fodero-Tavoletti, MP Hardy, B Cornell, F Katsis, CM Sadek, CA Mitchell, BE Kemp, T Tiganis

Journal article  |  2005  |  Biochemical Journal

Kinetic properties of nuclear transport conferred by the retinoblastoma (Rb) NLS

W Hu, BE Kemp, DA Jans

Journal article  |  2005  |  Journal of Cellular Biochemistry

Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics

MB Chen, AJ McAinch, SL Macaulay, LA Castelli, PE O'Brien, JB Dixon, D Cameron-Smith, BE Kemp, GR Steinberg

Journal article  |  2005  |  Journal of Clinical Endocrinology & Metabolism

AMP-activated protein kinase beta subunit tethers alpha and gamma Subunits via its C-terminal sequence (186-270)

TJ Iseli, M Walter, BJW van Denderen, F Katsis, LA Witters, BE Kemp, BJ Michell, D Stapleton

Journal article  |  2005  |  Journal of Biological Chemistry

Prevailing hyperglycemia is critical in the regulation of glucose metabolism during exercise in poorly controlled alloxan-diabetic dogs

MJ Christopher, C Rantzau, G McConell, BE Kemp, FP Alford

Journal article  |  2005  |  Journal of Applied Physiology

Breast cancer protein StarD10 identified by three-dimensional separation using free-flow electrophoresis, reversed-phase high-performance liquid chromatography, and sodium dodecyl sulfate polyacrylamide gel electrophoresis

P Hoffmann, MA Olayioye, RL Moritz, GJ Lindeman, JE Visvader, RJ Simpson, BE Kemp

Journal article  |  2005  |  Electrophoresis

Regulation of the energy sensor AMP-activated protein kinase in the kidney by dietary salt intake and osmolality

Scott Fraser, Peter Mount, Rebecca Hill, Vicki Levidiotis, Frosa Katsis, David Stapleton, Bruce E Kemp, David A Power

Journal article  |  2005  |  American Journal of Physiology: Renal Physiology

The AMP-activated protein kinase (AMPK) is a key controller of cellular energy metabolism. We studied its expression and regulatio..

Prediction of heart failure by amino terminal-pro-B-type natriuretic peptide and C-reactive protein in subjects with cerebrovascular disease

DJ Campbell, M Woodward, JP Chalmers, SA Colman, AJ Jenkins, BE Kemp, BC Neal, A Patel, SW MacMahon

Journal article  |  2005  |  Journal of Hypertension

Effect of exercise on protein kinase C activity and localization in human skeletal muscle

AJ Rose, BJ Michell, BE Kemp, M Hargreaves

Journal article  |  2004  |  Journal of Physiology

Insulin resistance does not diminish eNOS expression, phosphorylation, or binding to HSP-90

D Fulton, MB Harris, BE Kemp, RC Venema, MB Marrero, DW Stepp

Journal article  |  2004  |  American Journal of Physiology - Heart and Circulatory Physiology

Incidence immunoassay for distinguishing recent from established HIV-1 infection in therapy-naive populations

KM Wilson, EIM Johnson, HA Croom, KM Richards, L Doughty, PH Cunningham, BE Kemp, BM Branson, EM Dax

Journal article  |  2004  |  AIDS

AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females

GR Steinberg, AC Smith, BJW van Denderen, ZP Chen, S Murthy, DJ Campbell, GJF Heigenhauser, DJ Dyck, BE Kemp

Journal article  |  2004  |  Journal of Clinical Endocrinology & Metabolism

Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors

MB Harris, MA Blackstone, SG Sood, CY Li, JM Goolsby, VJ Venema, BE Kemp, RC Venema

Journal article  |  2004  |  American Journal of Physiology - Heart and Circulatory Physiology

Platelet-derived growth factor receptor transactivation mediates the trophic effects of angiotensin II in vivo

DJ Kelly, AJ Cox, RM Gow, Y Zhang, BE Kemp, RE Gilbert

Journal article  |  2004  |  Hypertension

Proteomic-based identification of haptoglobin-1 precursor as a novel circulating biomarker of ovarian cancer

N Ahmed, G Barker, KT Oliva, P Hoffmann, C Riley, S Reeve, AL Smith, BE Kemp, MA Quinn, GE Rice

Journal article  |  2004  |  British Journal of Cancer

Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle

MJ Watt, AG Holmes, GR Steinberg, JL Mesa, BE Kemp, MA Febbraio

Journal article  |  2004  |  American Journal of Physiology - Endocrinology and Metabolism

beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling

MJ Watt, GR Steinberg, S Chan, A Garnham, BE Kemp, MA Febbraio

Journal article  |  2004  |  FASEB Journal

The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis

P Bukczynska, M Klingler-Hoffmann, KI Mitchelhill, MHC Lam, M Ciccomancini, NK Tonks, B Sarcevic, BE Kemp, T Tiganis

Journal article  |  2004  |  Biochemical Journal

Expression and biochemical analysis of the entire HIV-2 gp41 ectodomain: determinants of stability map to N- and C-terminal sequences outside the 6-helix bundle core

CS Lay, KA Wilson, B Kobe, BE Kemp, HE Drummer, P Poumbourios

Journal article  |  2004  |  FEBS Letters

The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation

MA Olayioye, P Hoffmann, T Pomorski, J Armes, RJ Simpson, BE Kemp, GJ Lindeman, JE Visvader

Journal article  |  2004  |  Cancer Research

High-density lipoprotein and apolipoprotein Al increase endothelial NO synthase activity by protein association and multisite phosphorylation

BG Drew, NH Fidge, G Gallon-Beaumier, BE Kemp, BA Kingwell

Journal article  |  2004  |  Proceedings of the National Academy of Sciences of the United States of America

Intensified exercise training does not alter AMPK signaling in human skeletal muscle

SA Clark, ZP Chen, KT Murphy, RJ Aughey, MJ McKenna, BE Kemp, JA Hawley

Journal article  |  2004  |  American Journal of Physiology - Endocrinology and Metabolism

Reduced NOS3 phosphorylation mediates reduced NO/cGMP signaling in mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats

JM Sasser, JC Sullivan, AA Elmarakby, BE Kemp, DM Pollock, JS Pollock

Journal article  |  2004  |  Hypertension

Mutations in the Gal83 glycogen-binding domain activate the Snf1/Gal83 kinase pathway by a glycogen-independent mechanism

HA Wiatrowski, BJW van Denderen, CD Berkey, BE Kemp, D Stapleton, M Carlson

Journal article  |  2004  |  Molecular and Cellular Biology

Intrasteric control of AMPK via the gamma(1) subunit AMP allosteric regulatory site

J Adams, ZP Chen, BJW Van Denderen, CJ Morton, MW Parker, LA Witters, D Stapleton, BE Kemp

Journal article  |  2004  |  Protein Science

Bateman domains and adenosine derivatives form a binding contract

BE Kemp

Journal article  |  2004  |  Journal of Clinical Investigation

Skeletal muscle basal AMP-activated protein kinase activity is chronically elevated in alloxan-diabetic dogs: impact of exercise

MJ Christopher, ZP Chen, C Rantzau, BE Kemp, FP Alford

Journal article  |  2003  |  Journal of Applied Physiology

Endothelial NO synthase phosphorylated at Ser(635) produces no without requiring intracellular calcium increase

YC Boo, GP Sorescu, PM Bauer, D Fulton, BE Kemp, DG Harrison, WC Sessa, H Jo

Journal article  |  2003  |  Free Radical Biology and Medicine

Effect of exercise intensity on skeletal muscle AMPK signaling in humans

ZP Chen, TJ Stephens, S Murthy, BJ Canny, M Hargreaves, LA Witters, BE Kemp, GK McConell

Journal article  |  2003  |  Diabetes

Identification of a parathyroid hormone in the fish Fugu rubripes

JA Danks, PMW Ho, AJ Notini, F Katsis, P Hoffmann, BE Kemp, TJ Martin, JD Zajac

Journal article  |  2003  |  Journal of Bone and Mineral Research

AMPK beta subunit targets metabolic stress sensing to glycogen

G Polekhina, A Gupta, BJ Michell, B van Denderen, S Murthy, SC Feil, IG Jennings, DJ Campbell, LA Witters, MW Parker, BE Kemp, D Stapleton

Journal article  |  2003  |  Current Biology

Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple-serine phosphorylation sites in endothelial nitric-oxide synthase

PM Bauer, D Fulton, YC Boo, GP Sorescu, BE Kemp, H Jo, WC Sessa

Journal article  |  2003  |  Journal of Biological Chemistry

Exercise increases nuclear AMPK alpha(2) in human skeletal muscle

SL McGee, KF Howlett, RL Starkie, D Cameron-Smith, BE Kemp, M Hargreaves

Journal article  |  2003  |  Diabetes

Regulation of 5 ' AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle

JFP Wojtaszewski, C MacDonald, JN Nielsen, Y Hellsten, DG Hardie, BE Kemp, B Kiens, EA Richter

Journal article  |  2003  |  American Journal of Physiology - Endocrinology and Metabolism

AMP-activated protein kinase, super metabolic regulator

BE Kemp, D Stapleton, DJ Campbell, ZP Chen, S Murthy, M Walter, A Gupta, JJ Adams, F Katsis, B van Denderen, IG Jennings, T Iseli, BJ Michell, LA Witters

Journal article  |  2003  |  Biochemical Society Transactions

Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension

DJ Kelly, YA Zhang, C Hepper, RM Gow, K Jaworski, BE Kemp, JL Wilkinson-Berka, RE Gilbert

Journal article  |  2003  |  Diabetes

Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells

KR Hallows, JE McCane, BE Kemp, LA Witters, JK Foskett

Journal article  |  2003  |  Journal of Biological Chemistry

A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

N Kimura, C Tokunaga, S Dalal, C Richardson, K Yoshino, K Hara, BE Kemp, LA Witters, O Mimura, K Yonezawa

Journal article  |  2003  |  Genes to Cells

Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism

YC Boo, J Hwang, M Sykes, BJ Michell, BE Kemp, H Lum, H Jo

Journal article  |  2002  |  American Journal of Physiology - Heart and Circulatory Physiology

Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635

BJ Michell, MB Harris, ZP Chen, H Ju, VJ Venema, MA Blackstone, W Huang, RC Venema, BE Kemp

Journal article  |  2002  |  Journal of Biological Chemistry

Role of 5 ' AMP-activated protein kinase in glycogen synthase activity and glucose utilization: insights from patients with McArdle's disease

JN Nielsen, JFP Wojtaszewski, RG Haller, DG Hardie, BE Kemp, EA Richter, J Vissing

Journal article  |  2002  |  Journal of Physiology

AMP-activated protein kinase kinase: detection with recombinant AMPK alpha 1 subunit

SR Hamilton, JB O'Donnell, A Hammet, D Stapleton, SA Habinowski, AR Means, BE Kemp, LA Witters

Journal article  |  2002  |  Biochemical and Biophysical Research Communications

Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice

XJ Du, TJ Cole, N Tenis, XM Gao, F Kontgen, BE Kemp, J Heierhorst

Journal article  |  2002  |  Molecular and Cellular Biology

Progressive increase in human skeletal muscle AMPK alpha 2 activity and ACC phosphorylation during exercise

TJ Stephens, ZP Chen, BJ Canny, BJ Michell, BE Kemp, GK McConell

Journal article  |  2002  |  American Journal of Physiology - Endocrinology and Metabolism

Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme

D Fulton, J Fontana, G Sowa, JP Gratton, M Lin, KX Li, B Michell, BE Kemp, D Rodman, WC Sessa

Journal article  |  2002  |  Journal of Biological Chemistry

Malonyl-CoA decarboxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or an islet cell line

SA Habinowski, M Hirshman, K Sakamoto, BE Kemp, SJ Gould, LJ Goodyear, LA Witters

Journal article  |  2001  |  Archives of Biochemistry and Biophysics

Cellular stress regulates the nucleocytoplasmic distribution of the protein-tyrosine phosphatase TCPTP

MHC Lam, BJ Michell, MT Fodero-Tavoletti, BE Kemp, NK Tonks, T Tiganis

Journal article  |  2001  |  Journal of Biological Chemistry

An activating mutation in the gamma 1 subunit of the AMP-activated protein kinase

SR Hamilton, D Stapleton, JB O'Donnell, JT Kung, SR Dalal, BE Kemp, LA Witters

Journal article  |  2001  |  FEBS Letters

Phosphorylation of Thr(495) regulates Ca2 /calmodulin-dependent endothelial nitric oxide synthase activity

I Fleming, B Fisslthaler, S Dimmeler, BE Kemp, R Busse

Journal article  |  2001  |  Circulation Research

Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase

BJ Michell, ZP Chen, T Tiganis, D Stapleton, F Katsis, DA Power, AT Sim, BE Kemp

Journal article  |  2001  |  Journal of Biological Chemistry

Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation

MB Harris, H Ju, VJ Venema, HY Liang, R Zou, BJ Michell, ZP Chen, BE Kemp, RC Venema

Journal article  |  2001  |  Journal of Biological Chemistry

Human factor H-related protein 5 (FHR-5) - A new complement-associated protein

JL McRae, PJ Cowan, DA Power, KI Mitchelhill, BE Kemp, BP Morgan, BF Murphy

Journal article  |  2001  |  Journal of Biological Chemistry

Aminoguanidine and ramipril prevent diabetes-induced increases in protein kinase C activity in glomeruli, retina and mesenteric artery

TM Osicka, YX Yu, V Lee, S Panagiotopoulos, BE Kemp, G Jerums

Journal article  |  2001  |  Clinical Science

Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization

SM Warden, C Richardson, J O'Donnell, D Stepleton, BE Kemp, LA Witters

Journal article  |  2001  |  Biochemical Journal