Philip Peyton

Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) intiative: cardiovascular outcomes

W Scott Beattie, Manoj Lalu, Matthew Bocock, Simon Feng, Duminda N Wijeysundera, Peter Nagele, Lee A Fleisher, Andrea Kurz, Bruce Biccard, Kate Leslie, Simon Howell, Giovani Landoni, Hilary Grocott, Andre Lamy, Toby Richards, Paul Myles

Journal article  |  2021  |  BRITISH JOURNAL OF ANAESTHESIA

BACKGROUND: Adverse cardiovascular events are a leading cause of perioperative morbidity and mortality. The definitions of periope..

Effect of Intraoperative Low Tidal Volume vs Conventional Tidal Volume on Postoperative Pulmonary Complications in Patients Undergoing Major Surgery A Randomized Clinical Trial

Dharshi Karalapillai, Laurence Weinberg, Philip Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong O Tan, David Story, Mark O'Donnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Anthony Wilson, Ary Serpa Neto, Glenn Eastwood, Rinaldo Bellomo, Daryl A Jones

Journal article  |  2020  |  JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Importance: In patients who undergo mechanical ventilation during surgery, the ideal tidal volume is unclear. Objective: To determ..

Frequency of hyperoxaemia during and after major surgery

Dharshi Karalapillai, Laurence Weinberg, Philip J Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong Tan, David Story, Mark O'Donnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Anthony Wilson, Glenn Eastwood, Rinaldo Bellomo, Daryl Jones

Journal article  |  2020  |  ANAESTHESIA AND INTENSIVE CARE

The oxygen concentration (FiO2) and arterial oxygen tension (PaO2) delivered in patients undergoing major surgery is poorly unders..

Characteristics and outcomes of rapid response team activations for hypotension in orthopaedic patients

Joao GR Ramos, Richard Zhang, Brendan Maher, Andrew Hardidge, Laurence Weinberg, Ray Robbins, Phillip J Peyton, Rinaldo Bellomo, Daryl Jones

Journal article  |  2020  |  INTERNAL MEDICINE JOURNAL

BACKGROUND: Hypotension following orthopaedic surgery has been associated with increased morbidity and mortality. Rapid response t..

Low tidal volume ventilation during anaesthesia for major surgery: protocol and statistical analysis plan

Dharshi Karalapillai, Laurence Weinberg, Phil Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong Tan, David Story, Mark ODonnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Anthony Wilson, Ary Serpa Neto, Glenn Eastwood, Rinaldo Bellomo, Daryl A Jones

Journal article  |  2019  |  CRITICAL CARE AND RESUSCITATION

BACKGROUND: Mechanical ventilation is mandatory in patients undergoing general anaesthesia for major surgery. Tidal volumes higher..

Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine initiative: clinical indicators

Guy Haller, Sohail Bampoe, Tim Cook, Lee A Fleisher, Michael PW Grocott, Mark Neuman, David Story, Paul S Myles, Paul Myles, Michael Grocott, Bruce Biccard, Jane Blazeby, Oliver Boney, Matthew Chan, Elisabeth Diouf, Lee Fleisher, Cor Kalkman, Andrea Kurz, Ramani Moonesinghe, Duminda Wijeysundera

Journal article  |  2019  |  BRITISH JOURNAL OF ANAESTHESIA

BACKGROUND: Clinical indicators are powerful tools to quantify the safety and quality of patient care. Their validity is often unc..

Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis

Jonathan Barnes, Jennifer Hunter, Steve Harris, Manu Shankar-Hari, Elisabeth Diouf, Ib Jammer, Cor Kalkman, Andrew A Klein, Tomas Corcoran, Stefan Dieleman, Michael PW Grocott, Michael G Mythen

Journal article  |  2019  |  BRITISH JOURNAL OF ANAESTHESIA

BACKGROUND: Perioperative infection and sepsis are of fundamental concern to perioperative clinicians. However, standardised endpo..

Tranexamic acid in coronary artery surgery: One-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) trial

Paul S Myles, Julian A Smith, Jessica Kasza, Brendan Silbert, Mohandas Jayarajah, Thomas Painter, D James Cooper, Silvana Marasco, John McNeil, Jean S Bussieres, Shay McGuinness, Kelly Byrne, Matthew TV Chan, Giovanni Landoni, Sophie Wallace, Andrew Forbes, Donald Esmore, Henry Krum, A Tonkin, B Buxton, et al.

Journal article  |  2019  |  JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

BACKGROUND: Tranexamic acid reduces blood loss and transfusion requirements in cardiac surgery but may increase the risk of corona..

Aspirin in coronary artery surgery: 1-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery trial

Paul S Myles, Julian A Smith, Jessica Kasza, Brendan Silbert, Mohandas Jayarajah, Thomas Painter, D James Cooper, Silvana Marasco, John McNeil, Jean S Bussieres, Shay McGuinness, Matthew TV Chan, Sophie Wallace, Andrew Forbes, Donald Esmore, Henry Krum, A Tonkin, B Buxton, S Heritier, A Merry, et al.

Journal article  |  2019  |  JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

BACKGROUND: Aspirin may reduce the risk of vascular graft thrombosis after cardiovascular surgery. We previously reported the 30-d..

Implication of Major Adverse Postoperative Events and Myocardial Injury on Disability and Survival: A Planned Subanalysis of the ENIGMA-II Trial

W Scott Beattie, Duminda N Wijeysundera, Matthew TV Chan, Philip J Peyton, Kate Leslie, Michael J Paech, Daniel I Sessler, Sophie Wallace, Paul S Myles

Journal article  |  2018  |  ANESTHESIA AND ANALGESIA

BACKGROUND: Globally, >300 million patients have surgery annually, and ≤20% experience adverse postoperative events. We studied th..