Philip Peyton

Systematic reviews and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: mortality, morbidity, and organ failure.

Alexander IR Jackson, Oliver Boney, Rupert M Pearse, Andrea Kurz, D James Cooper, Wilton A van Klei, Luca Cabrini, Timothy E Miller, S Ramani Moonesinghe, Paul S Myles, Michael PW Grocott, undefined StEP-COMPACGroup

Journal article  |  2023  |  Br J Anaesth

BACKGROUND: Mortality, morbidity, and organ failure are important and common serious harms after surgery. However, there are many ..

Postoperative Pulmonary Complications in the ENIGMA II Trial: A Post Hoc Analysis.

Philip J Peyton, Grace Liskaser, Alexander Ho, Harry Marsh, Christopher Etherington, Frederick Torlot, Manisha Desai, George Perrett, Brian Chee, Kate Leslie, Paul S Myles

Journal article  |  2023  |  Anesthesiology

BACKGROUND: Nitrous oxide promotes absorption atelectasis in poorly ventilated lung segments at high inspired concentrations. The ..

Low tidal volume ventilation for patients undergoing laparoscopic surgery: a secondary analysis of a randomised clinical trial.

Dharshi Karalapillai, Laurence Weinberg, Ary Serpa Neto, Philip J Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong O Tan, David Story, Mark O'Donnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Anthony Wilson, Grace Liskaser, Ajay Balasubramaniam, Glenn Eastwood, Rinaldo Bellomo, Daryl A Jones

Journal article  |  2023  |  BMC Anesthesiol

BACKGROUND: We recently reported the results for a large randomized controlled trial of low tidal volume ventilation (LTVV) versus..

Diffusion Limitation of Volatile Anesthetic Uptake: Reply.

Philip J Peyton

Journal article  |  2023  |  Anesthesiology

High-flow oxygen via oxygenating mouthguard in short upper gastrointestinal endoscopy: A randomised controlled trial

Kim Hay Be, Leonardo Zorron Cheng Tao Pu, Brett Pearce, Matthew Lee, Luke Fletcher, Rebecca Cogan, Philip Peyton, Rhys Vaughan, Marios Efthymiou, Sujievvan Chandran

Journal article  |  2022  |  WORLD JOURNAL OF GASTROINTESTINAL ENDOSCOPY

BACKGROUND: Anaesthetic care during upper gastrointestinal (GI) endoscopy has the unique challenge of maintaining ventilation and ..

Approaches to prioritising research for clinical trial networks: a scoping review.

Rachael L Morton, Haitham Tuffaha, Vendula Blaya-Novakova, Jenean Spencer, Carmel M Hawley, Phil Peyton, Alisa Higgins, Julie Marsh, William J Taylor, Sue Huckson, Amy Sillett, Kieran Schneemann, Anitha Balagurunanthan, Miranda Cumpston, Paul A Scuffham, Paul Glasziou, Robert J Simes

Journal article  |  2022  |  Trials

BACKGROUND: Prioritisation of clinical trials ensures that the research conducted meets the needs of stakeholders, makes the best ..

Inclusion, characteristics, and outcomes of male and female participants in large international perioperative studies.

Kate Leslie, Catherine Martin, Paul S Myles, PJ Devereaux, Philip J Peyton, David A Story, Duminda N Wijeysundera, Brian H Cuthbertson, Timothy G Short, Tomás B Corcoran, Jessica Kasza

Journal article  |  2022  |  Br J Anaesth

BACKGROUND: We compared baseline characteristics and outcomes and evaluated the subgroup effects of randomised interventions by se..

Postoperative anaemia and patient-centred outcomes after major abdominal surgery: a retrospective cohort study.

Paul S Myles, Toby Richards, Andrew Klein, Erica M Wood, Sophie Wallace, Mark A Shulman, Catherine Martin, Rinaldo Bellomo, Tomás B Corcoran, Philip J Peyton, David A Story, Kate Leslie, Andrew Forbes, undefined RELIEF Trial Investigators

Journal article  |  2022  |  Br J Anaesth

BACKGROUND: Compared with anaemia before surgery, the underlying pathogenesis and implications of postoperative anaemia are largel..

Methylomic and transcriptomic characterization of postoperative systemic inflammatory dysregulation.

Chris R Bain, Paul S Myles, Rachael Taylor, Hugh Trahair, Yin Peng Lee, Larry Croft, Philip J Peyton, Thomas Painter, Matthew TV Chan, Sophie Wallace, Tomás Corcoran, Andrew D Shaw, Eldho Paul, Mark Ziemann, Kiymet Bozaoglu

Journal article  |  2022  |  Transl Res

In this study, we define and validate a state of postoperative systemic inflammatory dysregulation (PSID) based on postoperative p..

Gas Phase Diffusion Does Not Limit Lung Volatile Anesthetic Uptake Rate.

Philip J Peyton

Journal article  |  2022  |  Anesthesiology

BACKGROUND: Inefficiency of lung gas exchange during general anesthesia is reflected in alveolar (end-tidal) to arterial (end-tida..