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Granulocyte-Macrophage Colony Stimulating Factor As an Indirect Mediator of Nociceptor Act..
Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macro..
Displaying the 47 most recent projects by John Hamilton.
Displaying the 381 most recent scholarly works by John Hamilton.
CCL17 in Inflammation and Pain.
Kevin M-C Lee, Andrew Jarnicki, Adrian Achuthan, Andrew J Fleetwood, Gary P Anderson, Christian Ellson, Maria Feeney, Louise K Modis, Julia E Smith, John A Hamilton, Andrew Cook
Journal article | 2020 | The Journal of Immunology
It has been reported that a GM-CSF→CCL17 pathway, originally identified in vitro in macrophage lineage populations, is implicated ..
Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice
KM-C Lee, V Prasad, A Achuthan, AJ Fleetwood, JA Hamilton, AD Cook
Journal article | 2020 | Osteoarthritis and Cartilage
OBJECTIVES: Pharmacological options for treating osteoarthritis (OA) are limited and alternative treatments are required. Given th..
Granulocyte-Macrophage Colony Stimulating Factor As an Indirect Mediator of Nociceptor Activation and Pain
Damini Tewari, Andrew D Cook, Ming-Chin Lee, Anne D Christensen, Andrew Croxford, Burkhard Becher, Daniel Poole, Pradeep Rajasekhar, Nigel Bunnett, Julia E Smith, John A Hamilton, Stephen B McMahon
Journal article | 2020 | The Journal of Neuroscience
The interaction between the immune system and the nervous system has been at the center of multiple research studies in recent yea..
Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells.
Aoife M McGinley, Caroline E Sutton, Sarah C Edwards, Charlotte M Leane, Joseph DeCourcey, Ana Teijeiro, John A Hamilton, Louis Boon, Nabil Djouder, Kingston HG Mills
Journal article | 2020 | Immunity
Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treat..
Microglial polarization in posttraumatic epilepsy: Potential mechanism and treatment opportunity
Peravina Therajaran, John A Hamilton, Terence J O'Brien, Nigel C Jones, Idrish Ali
Journal article | 2020 | Epilepsia
Owing to the complexity of the pathophysiological mechanisms driving epileptogenesis following traumatic brain injury (TBI), effec..
Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages
David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood
Journal article | 2019 | Journal of Clinical Investigation
Glycolysis Is Required for LPS-Induced Activation and Adhesion of Human CD14( )CD16(-) Monocytes
Man KS Lee, Annas Al-Sharea, Waled A Shihata, Camilla Bertuzzo Veiga, Olivia D Cooney, Andrew J Fleetwood, Michelle C Flynn, Ellen Claeson, Clovis S Palmer, Graeme I Lancaster, Darren C Henstridge, John A Hamilton, Andrew J Murphy
Journal article | 2019 | Frontiers in Immunology
A Functional Immune System Is Required for the Systemic Genotoxic Effects of Localized Irradiation
Pavel N Lobachevsky, Jessica Ventura, Lina Giannakandropoulou, Helen Forrester, Jason S Palazzolo, Nicole M Haynes, Andrew W Stevenson, Christopher J Hall, Joel Mason, Gerasimos Pollakis, Ioannis S Pateras, Vassilis Gorgoulis, Georgia I Terzoudi, John A Hamilton, Carl N Sprung, Alexandros G Georgakilas, Olga A Martin
Journal article | 2019 | International Journal of Radiation Oncology*Biology*Physics
Pulmonary alveolar proteinosis.
Bruce C Trapnell, Koh Nakata, Francesco Bonella, Ilaria Campo, Matthias Griese, John Hamilton, Tisha Wang, Cliff Morgan, Vincent Cottin, Cormac McCarthy
Journal article | 2019 | Nature Reviews Disease Primers
Pulmonary alveolar proteinosis (PAP) is a syndrome characterized by the accumulation of alveolar surfactant and dysfunction of alv..
Localized synchrotron radiation in mice induces persistent systemic genotoxic events mediated by the functional immune system
Jessica Ventura, Pavel Lobachevsky, Jason Palazzolo, Helen Forrester, Nicole Haynes, Alesia Ivashkevich, Andrew Stevenson, Christopher Hall, Vassilis Gorgoulis, John Hamilton, Alexandros Georgakilas, Calr Sprung, Olga A Martin
Conference Proceedings | 2018 | Clinical Research (Excluding Clinical Trials)
TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17
Andrew D Cook, Ming-Chin Lee, Reem Saleh, Hsu-Wei Khiew, Anne D Christensen, Adrian Achuthan, Andrew J Fleetwood, Derek C Lacey, Julia E Smith, Irmgard Foerster, John A Hamilton
Journal article | 2018 | JCI Insight
Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity
Adrian Achuthan, Ahmad SM Aslam, Nguyen Quyen, Pui-Yeng Lam, Andrew J Fleetwood, Ashlee T Frye, Cynthia Louis, Ming-Chin Lee, Julia E Smith, Andrew D Cook, Moshe Olshansky, Stephen J Turner, John A Hamilton
Journal article | 2018 | Cell Death & Disease
Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles
Andrew J Fleetwood, Man KS Lee, William Singleton, Adrian Achuthan, Ming-Chin Lee, Neil M O'Brien-Simpson, Andrew D Cook, Andrew J Murphy, Stuart G Dashper, Eric C Reynolds, John A Hamilton
Journal article | 2017 | Frontiers in Cellular and Infection Microbiology
G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease
Ming-Chin Lee, James A McCubbin, Anne D Christensen, Daniel P Poole, Pradeep Rajasekhar, TinaMarie Lieu, Nigel W Bunnett, Sonia Garcia-Caraballo, Andelain Erickson, Stuart M Brierley, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Robin L Anderson, John A Hamilton, Andrew D Cook
Journal article | 2017 | The Journal of Immunology
Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases.
John A Hamilton, Andrew D Cook, Paul P Tak
Journal article | 2016 | Nature Reviews Drug Discovery
Granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF; also known as CSF1), granu..
Granulocyte macrophage colony-stimulating factor induces CCL17 pro uction via IRF4 to mediate inflammation
Adrian Achuthan, Andrew D Cook, Ming-Chin Lee, Reem Saleh, Hsu-Wei Khiew, Melody WN Chang, Cynthia Louis, Andrew J Fleetwood, Derek C Lacey, Anne D Christensen, Ashlee T Frye, Pui Yeng Lam, Hitoshi Kusano, Koji Nomura, Nancy Steiner, Irmgard Foerster, Stephen L Nutt, Moshe Olshansky, Stephen J Turner, John A Hamilton
Journal article | 2016 | Journal of Clinical Investigation
OSCAR-collagen signaling in monocytes plays a proinflammatory role and may contribute to the pathogenesis of rheumatoid arthritis
Heidi S Schultz, Li Guo, Pernille Keller, Andrew J Fleetwood, Mingyi Sun, Wei Guo, Chunyan Ma, John A Hamilton, Olle Bjorkdahl, Martin W Berchtold, Svetlana Panina
Journal article | 2016 | European journal of immunology
TLR3 drives IRF6-dependent IL-23p19 expression and p19/EBI3 heterodimer formation in keratinocytes
Divya Ramnath, Kathryn Tunny, Daniel M Hohenhaus, Claire M Pitts, Anne-Sophie Bergot, P Mark Hogarth, John A Hamilton, Ronan Kapetanovic, Richard A Sturm, Glen M Scholz, Matthew J Sweet
Journal article | 2015 | Immunology & Cell Biology
GM-CSF and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model
Roselind S Lam, Neil M O'Brien-Simpson, John A Hamilton, Jason C Lenzo, James A Holden, Gail C Brammar, Rebecca K Orth, Yan Tan, Katrina A Walsh, Andrew J Fleetwood, Eric C Reynolds
Journal article | 2015 | Immunology & Cell Biology
Tibial fracture exacerbates traumatic brain injury outcomes and neuroinflammation in a novel mouse model of multitrauma
Sandy R Shultz, Mujun Sun, David K Wright, Rhys D Brady, Shijie Liu, Sinead Beynon, Shannon F Schmidt, Andrew H Kaye, John A Hamilton, Terence J O'Brien, Brian L Grills, Stuart J McDonald
Journal article | 2015 | Journal of Cerebral Blood Flow & Metabolism
Porphyromonas gingivalis-derived RgpA-Kgp Complex Activates the Macrophage Urokinase Plasminogen Activator System IMPLICATIONS FOR PERIODONTITIS
Andrew J Fleetwood, Neil M O'Brien-Simpson, Paul D Veith, Roselind S Lam, Adrian Achuthan, Andrew D Cook, William Singleton, Ida K Lund, Eric C Reynolds, John A Hamilton
Journal article | 2015 | Journal of Biological Chemistry
Collagen Induces Maturation of Human Monocyte-Derived Dendritic Cells by Signaling through Osteoclast-Associated Receptor
Heidi S Schultz, Louise M Nitze, Louise H Zeuthen, Pernille Keller, Albrecht Gruhler, Jesper Pass, Jianhe Chen, Li Guo, Andrew J Fleetwood, John A Hamilton, Martin W Berchtold, Svetlana Panina
Journal article | 2015 | The Journal of Immunology
High numbers of circulating pigmented polymorphonuclear neutrophils as a prognostic marker for decreased birth weight during malaria in pregnancy
Caroline Lin Lin Chua, Leanne J Robinson, Francesca Baiwog, Danielle I Stanisic, John A Hamilton, Graham V Brown, Stephen J Rogerson, Philippe Boeuf
Journal article | 2015 | International Journal for Parasitology
Receptor-interacting Protein Kinase 4 and Interferon Regulatory Factor 6 Function as a Signaling Axis to Regulate Keratinocyte Differentiation
Mei Qi Kwa, Jennifer Huynh, Jiamin Aw, Lianyi Zhang, Nguyen Thao, Eric C Reynolds, Matthew J Sweet, John A Hamilton, Glen M Scholz
Journal article | 2014 | Journal of Biological Chemistry
Granulocyte-Macrophage Colony-Stimulating Factor Drives Monosodium Urate Monohydrate Crystal-Induced Inflammatory Macrophage Differentiation and NLRP3 Inflammasome Up-Regulation in an In Vivo Mouse Model
Odette M Shaw, Stefanie Steiger, Xiao Liu, John A Hamilton, Jacquie L Harper
Journal article | 2014 | Arthritis & Rheumatology
SAA drives proinflammatory heterotypic macrophage differentiation in the lung via CSF-1R-dependent signaling
Desiree Anthony, Jonathan L McQualter, Maria Bishara, Ee X Lim, Selcuk Yatmaz, Huei Jiunn Seow, Michelle Hansen, Michelle Thompson, John A Hamilton, Louis B Irving, Bruce D Levy, Ross Vlahos, Gary P Anderson, Steven Bozinovski
Journal article | 2014 | The FASEB Journal
The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor
Agnieszka Swierczak, Andrew D Cook, Jason C Lenzo, Christina M Restall, Judy P Doherty, Robin L Anderson, John A Hamilton
Journal article | 2014 | Cancer Immunology Research
Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
Peter J Murray, Judith E Allen, Subhra K Biswas, Edward A Fisher, Derek W Gilroy, Sergij Goerdt, Siamon Gordon, John A Hamilton, Lionel B Ivashkiv, Toby Lawrence, Massimo Locati, Alberto Mantovani, Fernando O Martinez, Jean-Louis Mege, David M Mosser, Gioacchino Natoli, Jeroen P Saeij, Joachim L Schultze, Kari Ann Shirey, Antonio Sica, et al.
Journal article | 2014 | Immunity
Interferon Regulatory Factor 6 Differentially Regulates Toll-like Receptor 2-dependent Chemokine Gene Expression in Epithelial Cells
Mei Qi Kwa, Nguyen Thao, Huynh Jennifer, Divya Ramnath, Dominic De Nardo, Pui Yeng Lam, Eric C Reynolds, John A Hamilton, Matthew J Sweet, Glen M Scholz
Journal article | 2014 | Journal of Biological Chemistry
Granulocyte-Macrophage Colony-Stimulating Factor Is Neuroprotective in Experimental Traumatic Brain Injury
Sandy R Shultz, Xin L Tan, David K Wright, Shijie J Liu, Bridgette D Semple, Leigh Johnston, Nigel C Jones, Andrew D Cook, John A Hamilton, Terence J O'Brien
Journal article | 2014 | Journal of Neurotrauma
Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPAR gamma and 5-LO-dependent pathways
Ivan Ballesteros, Maria I Cuartero, Jesus M Pradillo, Juan de la Parra, Alberto Perez-Ruiz, Angel Corbi, Mercedes Ricote, John A Hamilton, Monica Sobrado, Jose Vivancos, Florentino Nombela, Ignacio Lizasoain, Maria A Moro
Journal article | 2014 | Journal of Leukocyte Biology
Characterization of pathogenic human monoclonal autoantibodies against GM-CSF
Yanni Wang, Christy A Thomson, Lenka L Allan, Linda M Jackson, Melanie Olson, Timothy R Hercus, Tracy L Nero, Amanda Turner, Michael W Parker, Angel L Lopez, Thomas K Waddell, Gary P Anderson, John A Hamilton, John W Schrader
Journal article | 2013 | Proceedings of the National Academy of Sciences of the United States of America
Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development
Andrew D Cook, Jarrad Pobjoy, Stefan Steidl, Manuela Duerr, Emma L Braine, Amanda L Turner, Derek C Lacey, John A Hamilton
Journal article | 2012 | Arthritis Research & Therapy
The TGF-beta superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism
Samuel N Breit, Heiko Johnen, Andrew D Cook, Vicky WW Tsai, Mohammad G Mohammad, Tamara Kuffner, Hong Ping Zhang, Christopher P Marquis, Lele Jiang, Glen Lockwood, Michelle Lee-Ng, Yasmin Husaini, Liyun Wu, John A Hamilton, David A Brown
Journal article | 2011 | Growth Factors
Regulation of Systemic and Local Myeloid Cell Subpopulations by Bone Marrow Cell-Derived Granulocyte-Macrophage Colony-Stimulating Factor in Experimental Inflammatory Arthritis
Andrew D Cook, Amanda L Turner, Emma L Braine, Jarrad Pobjoy, Jason C Lenzo, John A Hamilton
Journal article | 2011 | Arthritis and Rheumatism
Macrophage Activation and Differentiation Signals Regulate Schlafen-4 Gene Expression: Evidence for Schlafen-4 as a Modulator of Myelopoiesis
Wendy J van Zuylen, Valerie Garceau, Adi Idris, Kate Schroder, Katharine M Irvine, Jane E Lattin, Dmitry A Ovchinnikov, Andrew C Perkins, Andrew D Cook, John A Hamilton, Paul J Hertzog, Katryn J Stacey, Stuart Kellie, David A Hume, Matthew J Sweet
Journal article | 2011 | PLoS One
Neutralizing Granulocyte/Macrophage Colony-Stimulating Factor Inhibits Cigarette Smoke-induced Lung Inflammation
Ross Vlahos, Steven Bozinovski, Sheau Pyng Jamie Chan, Stefan Ivanov, Anders Linden, John A Hamilton, Gary P Anderson
Journal article | 2010 | American Journal of Respiratory and Critical Care Medicine
Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement
Andrew D Cook, Christine M De Nardo, Emma L Braine, Amanda L Turner, Ross Vlahos, Kerrie J Way, S Kaye Beckman, Jason C Lenzo, John A Hamilton
Journal article | 2010 | Arthritis Research & Therapy
The generation and properties of human macrophage populations from hemopoietic stem cells
Kerrie J Way, Hang Dinh, Martin R Keene, Kirby E White, Felix IL Clanchy, Patricia Lusby, John Roiniotis, Andrew D Cook, A Ian Cassady, David J Curtis, John A Hamilton
Journal article | 2009 | Journal of Leukocyte Biology
Urokinase-plasminogen activator derived from a bone marrow cell is required for the development of immune complex-mediated arthritis models
Andrew D Cook, Christine M Massa, Emma L Braine, Amanda L Turner, Kerrie J Way, S Kaye Beckman, John A Hamilton
Conference Proceedings | 2008 | ARTHRITIS AND RHEUMATISM
Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1
R Tedjo Sasmono, Achim Ehrnsperger, Stephen L Cronau, Timothy Ravasi, Rangi Kandane, Michael J Hickey, Andrew D Cook, S Roy Himes, John A Hamilton, David A Hume
Journal article | 2007 | Journal of Leukocyte Biology
Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: Implications for CSF blockade in inflammation
Andrew J Fleetwood, Toby Lawrence, John A Hamilton, Andrew D Cook
Journal article | 2007 | Journal of Immunology
Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes.
Douglas G Walker, John Link, Lih-Fen Lue, Jessica E Dalsing-Hernandez, Barry E Boyes
Journal article | 2006 | Journal of Leukocyte Biology
A central feature of the inflammatory pathology in Alzheimer's disease is activated microglia clustered around aggregated amyloid ..
Oleate-induced formation of fat cells with impaired insulin sensitivity.
Weisheng Xie, James A Hamilton, James L Kirkland, Barbara E Corkey, Wen Guo
Journal article | 2006 | Lipids
Exogenous FA cause lipid accumulation in pre-adipocytes. We investigated whether the fat cells thus formed are metabolically disti..
S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo
S Bozinovski, M Cross, R Vlahos, JE Jones, K Hsuu, PA Tessier, EC Reynolds, DA Hume, JA Hamilton, CL Geczy, GP Anderson
Journal article | 2005 | Journal of Proteome Research
Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF)
JA Hamilton, G Whitty, AR White, MF Jobling, A Thompson, CJ Barrow, R Cappai, K Beyreuther, CL Masters
Journal article | 2002 | Brain Research
Proteomic analysis of macrophage differentiation - p46/52(Shc) tyrosine phosphorylation is required for CSF-1-mediated macrophage differentiation
XF Csar, NJ Wilson, KA McMahon, DC Marks, TL Beecroft, AC Ward, GA Whitty, V Kanangasundarum, JA Hamilton
Journal article | 2001 | Journal of Biological Chemistry
Regulation of urokinase plasminogen activator gene transcription in the RAW264 murine macrophage cell line by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell-surface receptor
LF Fowles, KJ Stacey, D Marks, JA Hamilton, DA Hume
Journal article | 2000 | Biochemical Journal
Expression of a Y559F mutant CSF-1 receptor in M1 myeloid cells: a role for Src kinases in CSF-1 receptor-mediated differentiation.
DC Marks, XF Csar, NJ Wilson, U Novak, AC Ward, V Kanagasundarum, BW Hoffmann, JA Hamilton
Journal article | 1999 | Molecular Cell Biology Research Communications
We have established two M1 myeloid cell lines, M1/WT cells overexpressing the wild-type CSF-1 receptor and M1/Y559F cells expressi..
Protein phosphatase 2A is expressed in response to colony-stimulating factor 1 in macrophages and is required for cell cycle progression independently of extracellular signal-regulated protein kinase activity
NJ Wilson, ST Moss, XF Csar, AC Ward, JA Hamilton
Journal article | 1999 | Biochemical Journal
cAMP suppresses p21ras and Raf-1 responses but not the Erk-1 response to granulocyte-colony-stimulating factor: possible Raf-1-independent activation of Erk-1.
XF Csar, AC Ward, BW Hoffmann, GG Guy, JA Hamilton
Journal article | 1997 | The Biochemical journal
The cAMP analogue 8-bromo-cAMP (8BrcAMP) inhibits granulocyte-colony-stimulating factor (G-CSF)-stimulated DNA synthesis in myeloi..
Erratum: A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons α and β and alters macrophage responses (Proceedings of the National Academy of Sciences of the United State of America (Nov 21, 1995) 92 (11284- 11288))
SY Hwang, PJ Hertzog, KA Holland, SH Sumarsono, MJ Tymms, JA Hamilton, G Whitty, I Bertoncello, I Kola
Journal article | 1996 | Proceedings of the National Academy of Sciences of the United States of America
A NULL MUTATION IN THE GENE ENCODING A TYPE-I INTERFERON RECEPTOR COMPONENT ELIMINATES ANTIPROLIFERATIVE AND ANTIVIRAL RESPONSES TO INTERFERON-ALPHA AND INTERFERON-BETA AND ALTERS MACROPHAGE RESPONSES
SY HWANG, PJ HERTZOG, KA HOLLAND, SH SUMARSONO, MJ TYMMS, JA HAMILTON, G WHITTY, I BERTONCELLO, I KOLA
Journal article | 1995 | Proceedings of the National Academy of Sciences
CYTOKINE MODULATION OF PLASMINOGEN-ACTIVATOR INHIBITOR-1 (PAI-1) PRODUCTION BY HUMAN ARTICULAR-CARTILAGE AND CHONDROCYTES - DOWN-REGULATION BY TUMOR-NECROSIS-FACTOR-ALPHA AND UP-REGULATION BY TRANSFORMING GROWTH-FACTOR-BETA AND BASIC FIBROBLAST GROWTH-FACTOR
IK CAMPBELL, J WOJTA, U NOVAK, JA HAMILTON
Journal article | 1994 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Haematopoietic colony stimulating factors CSF-1 and GM-CSF increase phosphatidylinositol 3-kinase activity in murine bone marrow-derived macrophages.
P Yusoff, JA Hamilton, RD Nolan, WA Phillips
Journal article | 1994 | Growth Factors
The activity of phosphatidylinositol (PI) 3-kinase was examined in murine bone marrow-derived macrophages (BMM) stimulated with th..
THROMBIN STIMULATES EXPRESSION OF TISSUE-TYPE PLASMINOGEN-ACTIVATOR AND PLASMINOGEN-ACTIVATOR INHIBITOR TYPE-1 IN CULTURED HUMAN VASCULAR SMOOTH-MUSCLE CELLS
J WOJTA, M GALLICCHIO, H ZOELLNER, P HUFNAGL, K LAST, EL FILONZI, BR BINDER, JA HAMILTON, K MCGRATH
Journal article | 1993 | Thrombosis and Haemostasis
EFFECTS OF MACROPHAGE-COLONY-STIMULATING FACTOR ON HUMAN MONOCYTES - INDUCTION OF EXPRESSION OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR, BUT NOT OF SECRETED PROSTAGLANDIN-E2, INTERLEUKIN-6, INTERLEUKIN-1, OR TUMOR-NECROSIS-FACTOR-ALPHA
JA HAMILTON, GA WHITTY, H STANTON, A MEAGER
Journal article | 1993 | Journal of Leukocyte Biology
CYTOKINE REGULATION OF COLONY-STIMULATING FACTOR (CSF) PRODUCTION IN CULTURED HUMAN SYNOVIAL FIBROBLASTS .2. SIMILARITIES AND DIFFERENCES IN THE CONTROL OF INTERLEUKIN-1 INDUCTION OF GRANULOCYTE-MACROPHAGE CSF AND GRANULOCYTE-CSF PRODUCTION
JA HAMILTON, DS PICCOLI, J CEBON, JE LAYTON, P RATHANASWANI, SR MCCOLL, T LEIZER
Journal article | 1992 | Blood
TRANSFORMING GROWTH-FACTOR-BETA STIMULATES UROKINASE-TYPE PLASMINOGEN-ACTIVATOR AND DNA-SYNTHESIS, BUT NOT PROSTAGLANDIN-E2 PRODUCTION, IN HUMAN SYNOVIAL FIBROBLASTS
JA HAMILTON, DS PICCOLI, T LEIZER, DM BUTLER, M CROATTO, AKM ROYSTON
Journal article | 1991 | Proceedings of the National Academy of Sciences
NA /H EXCHANGE INVOLVEMENT IN COLONY-STIMULATING FACTOR-1-STIMULATED MACROPHAGE PROLIFERATION - EVIDENCE FOR A REQUIREMENT DURING LATE G1 OF THE CELL-CYCLE BUT NOT FOR EARLY GROWTH-FACTOR RESPONSES
G VAIRO, S ARGYRIOU, AM BORDUN, TJ GONDA, EJ CRAGOE, JA HAMILTON
Journal article | 1990 | Journal of Biological Chemistry
RECOMBINANT HUMAN INTERLEUKIN-1 STIMULATES HUMAN ARTICULAR-CARTILAGE TO UNDERGO RESORPTION AND HUMAN CHONDROCYTES TO PRODUCE BOTH TISSUE-TYPE AND UROKINASE-TYPE PLASMINOGEN-ACTIVATOR
IK CAMPBELL, DS PICCOLI, DM BUTLER, DK SINGLETON, JA HAMILTON
Journal article | 1988 | Biochimica et Biophysica Acta (BBA) - General Subjects
DIVERSE MORPHOLOGICAL RESPONSES OF NORMAL HUMAN SYNOVIAL FIBROBLASTS TO MONONUCLEAR LEUKOCYTE PRODUCTS - RELATIONSHIP TO PROSTAGLANDIN PRODUCTION AND PLASMINOGEN-ACTIVATOR ACTIVITIES, AND COMPARISON WITH THE EFFECTS OF PURIFIED INTERLEUKIN-1
BJ CLARRIS, T LEIZER, JRE FRASER, JA HAMILTON
Journal article | 1987 | Rheumatology International
CYCLIC AMP-DEPENDENT AND AMP-INDEPENDENT EFFECTS ON TISSUE-TYPE PLASMINOGEN-ACTIVATOR ACTIVITY IN OSTEOGENIC-SARCOMA CELLS - EVIDENCE FROM PHOSPHODIESTERASE INHIBITION AND PARATHYROID-HORMONE ANTAGONISTS
EH ALLAN, JA HAMILTON, RL MEDCALF, M KUBOTA, TJ MARTIN
Journal article | 1986 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Purification of two forms of colony-stimulating factor from mouse L-cell-conditioned medium.
AW Burgess, D Metcalf, IJ Kozka, RJ Simpson, G Vairo, JA Hamilton, EC Nice
Journal article | 1985 | Journal of Biological Chemistry
A modified procedure for the purification of the colony-stimulating factors (CSFs) in mouse L-cell-conditioned medium is used to i..
THE NATURE OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE (TPA)-STIMULATED HEMATOPOIESIS, COLONY STIMULATING FACTOR (CSF) REQUIREMENT FOR COLONY FORMATION, AND THE EFFECT OF TPA ON [I-125] CSF-1 BINDING TO MACROPHAGES
LJ GUILBERT, DJ NELSON, JA HAMILTON, N WILLIAMS
Journal article | 1983 | Journal of Cellular Physiology
STREPTOCOCCAL CELL-WALLS AND SYNOVIAL CELL ACTIVATION - STIMULATION OF SYNOVIAL FIBROBLAST PLASMINOGEN-ACTIVATOR ACTIVITY BY MONOCYTES TREATED WITH GROUP-A STREPTOCOCCAL CELL-WALL SONICATES AND MURAMYL DIPEPTIDE
JA HAMILTON, JB ZABRISKIE, LB LACHMAN, YS CHEN
Journal article | 1982 | The Journal of Experimental Medicine
Cell-to-cell interaction in the immune response. VII. Requirement for differentiation of thymus-derived cells.
JF Miller, J Sprent, A Basten, NL Warner, JC Breitner, G Rowland, J Hamilton, H Silver, WJ Martin
Journal article | 1971 | The Journal of Experimental Medicine
Experiments were designed to test the possibility that thymus-derived (T) cells cooperate with nonthymus derived (B) cells in anti..
Honours, Awards and Fellowships
Tattersall�s Research Award
Fraser Post-Graduate Medical Research Scholarship
Parr Rheumatic Prize
Senior Principal Research Fellow (Nh&Mrc
Medicine - Royal Melbourne Hospital
Doctor of Science
University of Melbourne
Doctor of Philosophy
University of Melbourne