John Hamilton

The role of interleukin (IL)-23 in regulating pain in arthritis COMMENT

Kevin M-C Lee, Jonathan P Sherlock, John A Hamilton

Journal article  |  2022  |  ARTHRITIS RESEARCH & THERAPY

Current understanding of IL-23 biology, with its link to other pro-inflammatory cytokines, for example, IL-17 and granulocyte macr..

Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization

Kevin Ming-Chin Lee, Adrian A Achuthan, David P De Souza, Tanya J Lupancu, Katrina J Binger, Man KS Lee, Yangsong Xu, Malcolm J McConville, Nicole A de Weerd, Dragana Dragoljevic, Paul J Hertzog, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal article  |  2022  |  CELL REPORTS

Metabolic adaptations can directly influence the scope and scale of macrophage activation and polarization. Here we explore the im..

Introduction to the Special Issue: The regulation of the immune system by colony stimulating factors (CSFs) in the steady state and pathology

John A Hamilton, Adrian A Achuthan

Journal article  |  2021  |  SEMINARS IN IMMUNOLOGY

Targeting GM-CSF in inflammatory and autoimmune disorders

Adrian A Achuthan, Kevin MC Lee, John A Hamilton

Journal article  |  2021  |  SEMINARS IN IMMUNOLOGY

Granulocyte macrophage-colony stimulating factor (GM-CSF) was originally identified as a growth factor for its ability to promote ..

RESPIRATORY SYNCYTIAL VIRUS EPIDEMIC DURING THE COVID-19 PANDEMIC

Hannah C Cooney, Catriona Fleming, Ingrid E Scheffer

Journal article  |  2021  |  JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells

Matthew Drill, Kim L Powell, Liyen Katrina Kan, Nigel C Jones, Terence J O'Brien, John A Hamilton, Mastura Monif

Journal article  |  2020  |  SCIENTIFIC REPORTS

Glioblastoma is the most aggressive form of primary brain cancer, with a median survival of 12–15 months. The P2X receptor 7 (P2X7..

CCL17 in Inflammation and Pain

Kevin M-C Lee, Andrew Jarnicki, Adrian Achuthan, Andrew J Fleetwood, Gary P Anderson, Christian Ellson, Maria Feeney, Louise K Modis, Julia E Smith, John A Hamilton, Andrew Cook

Journal article  |  2020  |  JOURNAL OF IMMUNOLOGY

It has been reported that a GM-CSF→CCL17 pathway, originally identified in vitro in macrophage lineage populations, is implicated ..

GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches

Frederick M Lang, Kevin M-C Lee, John R Teijaro, Burkhard Becher, John A Hamilton

Journal article  |  2020  |  NATURE REVIEWS IMMUNOLOGY

Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed. Granulocyte-macrophage colony-stimulating factor (GM..

IL-23 in arthritic and inflammatory pain development in mice

Kevin M-C Lee, Zihao Zhang, Adrian Achuthan, Andrew J Fleetwood, Julia E Smith, John A Hamilton, Andrew D Cook

Journal article  |  2020  |  ARTHRITIS RESEARCH & THERAPY

BACKGROUND: The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthriti..

Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice

KM-C Lee, V Prasad, A Achuthan, AJ Fleetwood, JA Hamilton, AD Cook

Journal article  |  2020  |  OSTEOARTHRITIS AND CARTILAGE

OBJECTIVES: Pharmacological options for treating osteoarthritis (OA) are limited and alternative treatments are required. Given th..