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Joint British Diabetes Societies for Inpatient Care: clinical guidelines and improving inp..
OCX063, A Novel Small Molecule Drug, Exhibits Anti-Inflammatory and Anti-Fibrotic Properti..
Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal f..
Thioredoxin-Interacting Protein: A Potential Therapeutic Target for Treatment of Progressi..
3 ',4 '-Bis-difluoromethoxycinnamoylanthranilate (FT061): An orally-active antifibrotic ag..
Displaying the 79 most recent scholarly works by Alison Cox.
Oral administration of the novel small molecule drug OCX063 protects against inflammation and vascular pathology in a rat diabetic retinopathy (DR) model
Roy Chze Khai Kong, Amanda Edgley, Elsa Chan, Alison J Cox, Sylwia Glowacka, Michelle Papadimitriou, Fay Lin Khong, Darren Kelly
Conference Proceedings | 2019 | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
3 ',4 '-Bis-difluoromethoxycinnamoylanthranilate (FT061): An orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy
Spencer J Williams, Steven C Zammit, Alison J Cox, David M Shackleford, Julia Morizzi, Yuan Zhang, Andrew K Powell, Richard E Gilbert, Henry Krum, Darren J Kelly
Journal article | 2013 | Bioorganic and Medicinal Chemistry Letters
A new anti-fibrotic drug attenuates cardiac remodeling and systolic dysfunction following experimental myocardial infarction
Yuan Zhang, Maros Elsik, Amanda J Edgley, Alison J Cox, Andrew R Kompa, Bing Wang, Christina Yan Ru Tan, Fay L Khong, David I Stapleton, Steven Zammit, Spencer J Williams, Richard E Gilbert, Henry Krum, Darren J Kelly
Journal article | 2013 | International Journal of Cardiology
eNOS Deficiency Predisposes Podocytes to Injury in Diabetes
Darren A Yuen, Bailey E Stead, Yanling Zhang, Kathryn E White, M Golam Kabir, Kerri Thai, Suzanne L Advani, Kim A Connelly, Tomoko Takano, Lei Zhu, Alison J Cox, Darren J Kelly, Ian W Gibson, Takamune Takahashi, Raymond C Harris, Andrew Advani
Journal article | 2012 | Journal of the American Society of Nephrology
FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy
Yuan Zhang, Amanda J Edgley, Alison J Cox, Andrew K Powell, Bing Wang, Andrew R Kompa, David I Stapleton, Steven C Zammit, Spencer J Williams, Henry Krum, Richard E Gilbert, Darren J Kelly
Journal article | 2012 | European Journal of Heart Failure
The (Pro) Renin Receptor Site-Specific and Functional Linkage to the Vacuolar H -ATPase in the Kidney
Andrew Advani, Darren J Kelly, Alison J Cox, Kathryn E White, Suzanne L Advani, Kerri Thai, Kim A Connelly, Darren Yuen, Judy Trogadis, Andrew M Herzenberg, Michael A Kuliszewski, Howard Leong-Poi, Richard E Gilbert
Journal article | 2009 | Hypertension
Protein kinase C-beta inhibition attenuates the progression of nephropathy in non-diabetic kidney disease
Darren J Kelly, Amanda J Edgley, Yuan Zhang, Kerri Thai, Sih Min Tan, Alison J Cox, Andrew Advani, Kim A Connelly, Catharine I Whiteside, Richard E Gilbert
Journal article | 2009 | Nephrology, Dialysis, Transplantation
Expression, Localization, and Function of the Thioredoxin System in Diabetic Nephropathy
Andrew Advani, Richard E Gilbert, Kerri Thai, Renae M Gow, Robyn G Langham, Alison J Cox, Kim A Connelly, Yuan Zhang, Andrew M Herzenberg, Per Knud Christensen, Carol A Pollock, Weier Qi, Sih Min Tan, Hans-Henrik Parving, Darren J Kelly
Journal article | 2009 | Journal of the American Society of Nephrology
Inhibition of Protein Kinase C-beta by Ruboxistaurin Preserves Cardiac Function and Reduces Extracellular Matrix Production in Diabetic Cardiomyopathy
Kim A Connelly, Darren J Kelly, Yuan Zhang, David L Prior, Andrew Advani, Alison J Cox, Kerri Thai, Henry Krum, Richard E Gilbert
Journal article | 2009 | Circulation. Heart Failure
Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions
Andrew Advani, Darren J Kelly, Suzanne L Advani, Alison J Cox, Kerri Thai, Yuan Zhang, Kathryn E White, Renae M Gow, Sally M Marshall, Brent M Steer, Philip A Marsden, P Elizabeth Rakoczy, Richard E Gilbert
Journal article | 2007 | Proceedings of the National Academy of Sciences of the United States of America
Effects on protein kinase C-beta inhibition on glomerular vascular endothelial growth factor expression and endothelial cells in advanced experimental diabetic nephropathy
Darren J Kelly, Danielle Buck, Alison J Cox, Yuan Zhang, Richard E Gilbert
Journal article | 2007 | American Journal of Physiology: Renal Physiology
Combination therapy with tranilast and angiotensin-converting enzyme inhibition provides additional renoprotection in the remnant kidney model.
DJ Kelly, Y Zhang, AJ Cox, RE Gilbert
Journal article | 2006 | Kidney International
Despite current therapy with agents that block the renin-angiotensin system, renal dysfunction continues to progress in a signific..
A study of VEGF and its receptors in two rat models of proteinuria.
John Kanellis, Vicki Levidiotis, Tiffany Khong, Alison J Cox, Steven A Stacker, Richard E Gilbert, Mark E Cooper, David A Power
Journal article | 2004 | Nephron
BACKGROUND: The high level of expression of vascular endothelial growth factor (VEGF) in normal podocyte foot processes suggests t..
Expression of the slit-diaphragm protein, nephrin, in experimental diabetic nephropathy: differing effects of anti-proteinuric therapies
DJ Kelly, P Aaltonen, AJ Cox, JR Rumble, R Langham, S Panagiotopoulos, G Jerums, H Holthofer, RE Gilbert
Journal article | 2002 | Nephrology, Dialysis, Transplantation
Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis.
Z Cao, DJ Kelly, A Cox, D Casley, JM Forbes, P Martinello, R Dean, RE Gilbert, ME Cooper
Journal article | 2000 | Kidney International
BACKGROUND: Angiotensin II (Ang II) is associated with cell proliferation and apoptosis. The role of the angiotensin type 2 recept..
Angiotensin converting enzyme inhibition reduces retinal overexpression of vascular endothelial growth factor and hyperpermeability in experimental diabetes
RE Gilbert, DJ Kelly, AJ Cox, JL Wilkinson-Berka, JR Rumble, T Osicka, S Panagiotopoulos, V Lee, EC Hendrich, G Jerums, ME Cooper
Journal article | 2000 | Diabetologia
Blockade of the renin-angiotensin and endothelin systems on progressive renal injury.
Z Cao, ME Cooper, LL Wu, AJ Cox, K Jandeleit-Dahm, DJ Kelly, RE Gilbert
Journal article | 2000 | Hypertension
The renin-angiotensin system (RAS) and endothelin system may both play a role in the pathogenesis of progressive renal injury. The..
Endothelin receptor antagonism ameliorates mast cell infiltration, vascular hypertrophy, and epidermal growth factor expression in experimental diabetes.
RE Gilbert, JR Rumble, Z Cao, AJ Cox, P van Eeden, TJ Allen, DJ Kelly, ME Cooper
Journal article | 2000 | Circulation Research
Vascular hypertrophy, a feature of experimental and human diabetes, has been implicated in the pathogenesis of the microvascular a..
SPARC gene expression is increased in diabetes-related mesenteric vascular hypertrophy.
K Jandeleit-Dahm, J Rumble, AJ Cox, DJ Kelly, M Dziadek, ME Cooper, RE Gilbert
Journal article | 2000 | Microvascular Research
The anti-adhesive extracellular matrix protein SPARC (secreted protein and rich in cysteine; osteonectin or BM-40) has been implic..
Pathological expression of renin and angiotensin II in the renal tubule after subtotal nephrectomy - Implications for the pathogenesis of tubulointerstitial fibrosis
RE Gilbert, LL Wu, DJ Kelly, A Cox, JL Wilkinson-Berka, CI Johnston, ME Cooper
Journal article | 1999 | The American Journal of Pathology
Role of hyperlipidemia in progressive renal disease: focus on diabetic nephropathy.
K Jandeleit-Dahm, Z Cao, AJ Cox, DJ Kelly, RE Gilbert, ME Cooper
Journal article | 1999 | Kidney International
BACKGROUND: It has been suggested that lipids promote renal injury and that 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reduct..
Angiotensin converting enzyme inhibition reduces the expression of transforming growth factor-beta1 and type IV collagen in diabetic vasculopathy.
JR Rumble, RE Gilbert, A Cox, L Wu, ME Cooper
Journal article | 1998 | Journal of Hypertension
OBJECTIVE: The purpose of this study was to assess the role of transforming growth factor (TGF)-beta1 in the development of diabet..
Secreted protein acidic and rich in cysteine expression after subtotal nephrectomy and blockade of the renin-angiotensin system.
LL Wu, A Cox, CJ Roe, M Dziadek, ME Cooper, RE Gilbert
Journal article | 1997 | Journal of the American Society of Nephrology
Secreted protein acidic and rich in cysteine (SPARC) is an extracellular matrix-associated protein with antiadhesive, antiprolifer..
Transforming growth factor beta 1 and renal injury following subtotal nephrectomy in the rat: role of the renin-angiotensin system.
LL Wu, A Cox, CJ Roe, M Dziadek, ME Cooper, RE Gilbert
Journal article | 1997 | Kidney International
Transforming growth factor-beta (TGF-beta) and the renin-angiotensin system (RAS) have both been implicated in the pathogenesis of..
Angiotensin-converting enzyme (ACE) gene polymorphism and the erythrocyte sodium-lithium countertransporter (SLC) phenotype in hypertension.
TC Hardman, AS Wierzbicki, P Croft, M Feher, A Cox, AF Lant
Conference Proceedings | 1996 | Journal of Human Hypertension
It has been suggested that the association between altered behaviour of the erythrocyte sodium-lithium countertransporter (SLC) an..
SPARC gene expression is reduced in early diabetes-related kidney growth.
RE Gilbert, PG McNally, A Cox, M Dziadek, J Rumble, ME Cooper, G Jerums
Conference Proceedings | 1995 | Kidney International
Renal enlargement is a characteristic feature of diabetes in humans and experimental animals that may predict subsequent renal dis..
Extracellular matrix and its interactions in the diabetic kidney: a molecular biological approach.
RE Gilbert, A Cox, M Dziadek, ME Cooper, G Jerums
Journal article | 1995 | Journal of Diabetes and its Complications
Increased extracellular matrix (ECM) is the ultrastructural hallmark of diabetic microangiopathy. Its accumulation within the kidn..
Association of angiotensin converting enzyme DD genotype with hypertension in diabetes.
AS Wierzbicki, L Nimmo, MD Feher, A Cox, J Foxton, AF Lant
Conference Proceedings | 1995 | Journal of Human Hypertension
Angiotensin converting enzyme (ACE) genotypes have been associated with hypertension in the general population. However, the relat..
Insulin receptor sub-types in a human lymphoid-derived cell line (IM-9): differential regulation by insulin, dexamethasone and monensin.
HA Jonas, AJ Cox
Journal article | 1991 | Journal of Receptor Research
The cells of the human IM-9 lymphocyte-derived line contain a subpopulation of insulin binding sites which differ from classical i..
Autocrine regulation of human tumor cell proliferation by insulin-like growth factor II: an in-vitro model.
MA Thompson, AJ Cox, RH Whitehead, HA Jonas
Journal article | 1990 | Endocrinology
We have shown that a pleomorphic cell line of abnormal human karyotype derived from a stomach carcinoma (LIM-1839) proliferates in..
Insulin-like growth factor binding to the atypical insulin receptors of a human lymphoid-derived cell line (IM-9).
HA Jonas, AJ Cox
Journal article | 1990 | Biochemical Journal
The cells of the IM-9 human lymphocyte-derived line contain a sub-population of insulin-binding sites whose immunological and horm..
Insulin-like growth factors and the developing and mature rat small intestine: receptors and biological actions.
GP Young, TM Taranto, HA Jonas, AJ Cox, A Hogg, GA Werther
Journal article | 1990 | Digestion
To determine if insulin-like growth factor-I (IGF-I) or multiplication stimulating activity (MSA, rat IGF-II) might directly influ..
Delineation of atypical insulin receptors from classical insulin and type I insulin-like growth factor receptors in human placenta.
HA Jonas, AJ Cox, LC Harrison
Journal article | 1989 | Biochemical Journal
Insulin-like growth factor (IGF)-binding sites copurifying with human placental insulin receptors during insulin-affinity chromato..
Production of IGF-binding proteins by vascular endothelial cells.
RS Bar, LC Harrison, RC Baxter, M Boes, BL Dake, B Booth, A Cox
Journal article | 1987 | Biochemical and Biophysical Research Communications
Conditioned serum-free media from cultured human, bovine and rodent endothelial cells contained binding proteins with high affinit..
Medicine - St Vincent'S Hospital
Australian Diabetes Society
Bachelor of Science
James Cook University of North Queensland