Timothy Hewitson

Vascular calcification in skin and subcutaneous tissue in patients with chronic and end-stage kidney disease

Irene Ruderman, Tim D Hewitson, Edward R Smith, Stephen G Holt, Belinda Wigg, Nigel D Toussaint

Journal article  |  2020  |  BMC Nephrology

BACKGROUND: Vascular calcification (VC) is well described in large- and medium-sized vessels in patients with chronic kidney disea..

Calciprotein particles: mineral behaving badly?

Edward R Smith, Tim D Hewitson, Willi Jahnen-Dechent

Journal article  |  2020  |  Current Opinion in Nephrology & Hypertension

PURPOSE OF REVIEW: Calciprotein particles (CPP) are formed in supersaturated solutions of calcium, phosphate and the mineral-bindi..

Monitoring skin temperature at the wrist in hospitalised patients may assist in the detection of infection

Stephen G Holt, Jennifer H Yo, Connie Karschimkus, Frank Volpato, Steve Christov, Edward R Smith, Tim D Hewitson, Leon J Worth, Paul Champion De Crespigny

Journal article  |  2020  |  Internal Medicine Journal

BACKGROUND: Measuring temperature has always been a key observation in the diagnosis of infection. No studies have examined the us..

alpha Klotho-FGF23 interactions and their role in kidney disease: a molecular insight

Edward R Smith, Stephen G Holt, Tim D Hewitson

Journal article  |  2019  |  Cellular and Molecular Life Sciences

Following the serendipitous discovery of the ageing suppressor, αKlotho (αKl), several decades ago, a growing body of evidence has..

Diagnostic Tests for Vascular Calcification

Edward R Smith, Tim D Hewitson, Stephen G Holt

Journal article  |  2019  |  Advances in Chronic Kidney Disease

Vascular calcification (VC) is the heterogeneous endpoint of multiple vascular insults, which varies by arterial bed, the layer of..

AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis

Bryna SM Chow, Martina Kocan, Matthew Shen, Yan Wang, Lei Han, Jacqueline Y Chew, Chao Wang, Sanja Bosnyak, Katrina M Mirabito-Colafella, Giannie Barsha, Belinda Wigg, Elizabeth KM Johnstone, Mohammed A Hossain, Kevin DG Pfleger, Kate M Denton, Robert E Widdop, Roger J Summers, Ross AD Bathgate, Tim D Hewitson, Chrishan S Samuel

Journal article  |  2019  |  Journal of the American Society of Nephrology

BACKGROUND: Recombinant human relaxin-2 (serelaxin), which has organ-protective actions mediated via its cognate G protein-coupled..

Profiling histone modifications in the normal mouse kidney and after unilateral ureteric obstruction

Timothy D Hewitson, Stephen G Holt, Chrishan S Samuel, Belinda Wigg, Edward R Smith

Journal article  |  2019  |  American Journal of Physiology-Renal Physiology

The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities

Jesse Roman, Teresa R Barnes, Dolly J Kervitsky, Gregory P Cosgrove, Dennis E Doherty, Andrew M Tager, Luca Richeldi, Eric S White, David A Brenner, Lynn M Schnapp, Timothy D Hewitson, Bodh I Jugdutt, Timothy A McKinsey, John D Tosi, Stephen Crane, Kevin K Brown

Journal article  |  2019  |  The American Journal of the Medical Sciences

TGF-beta 1 modifies histone acetylation and acetyl-coenzyme A metabolism in renal myofibroblasts

Edward R Smith, Belinda Wigg, Stephen G Holt, Timothy D Hewitson

Journal article  |  2019  |  American Journal of Physiology-Renal Physiology

Current and potential therapeutic strategies for the management of vascular calcification in patients with chronic kidney disease including those on dialysis

Irene Ruderman, Stephen G Holt, Tim D Hewitson, Edward R Smith, Nigel D Toussaint

Journal article  |  2018  |  Seminars in Dialysis

CALCIPROTEIN PARTICLE FORMATION IN PERITONEAL DIALYSIS EFFLUENT IS DEPENDENT ON DIALYSATE CALCIUM CONCENTRATION

Michael MX Cai, Edward R Smith, Annette Kent, Louis Huang, Timothy D Hewitson, Lawrence P McMahon, Stephen G Holt

Journal article  |  2018  |  Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis

Longitudinal changes in bone and mineral metabolism after cessation of cinacalcet in dialysis patients with secondary hyperparathyroidism

Irene Ruderman, Edward R Smith, Nigel D Toussaint, Tim D Hewitson, Stephen G Holt

Journal article  |  2018  |  BMC Nephrology

Biochemical transformation of calciprotein particles in uraemia

Edward R Smith, Tim D Hewitson, Eric Hanssen, Stephen G Holt

Journal article  |  2018  |  Bone

High-intensity physical exercise increases serum α-klotho levels in healthy volunteers.

Sven-Jean Tan, Melissa M Chu, Nigel D Toussaint, Michael Mx Cai, Tim D Hewitson, Stephen G Holt

Journal article  |  2018  |  Journal of Circulating Biomarkers

The recently discovered klotho proteins have roles in a diverse range of metabolic processes with the oldest protein, α-klotho, im..

Editorial: Novel Therapeutic Targets and Emerging Treatments for Fibrosis

Chrishan S Samuel, Timothy D Hewitson

Journal article  |  2017  |  Frontiers in Pharmacology

FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-beta autoinduction

Edward R Smith, Stephen G Holt, Tim D Hewitson

Journal article  |  2017  |  The International Journal of Biochemistry & Cell Biology

Fetuin-A in the peritoneal effluent of patients with encapsulating peritoneal sclerosis-more than a protein?

Edward R Smith, Tim D Hewitson, Michael MX Cai, Stephen G Holt

Journal article  |  2017  |  Kidney International

Progression of Tubulointerstitial Fibrosis and the Chronic Kidney Disease Phenotype - Role of Risk Factors and Epigenetics

Timothy D Hewitson, Stephen G Holt, Edward R Smith

Journal article  |  2017  |  Frontiers in Pharmacology

A novel fluorescent probe-based flow cytometric assay for mineral-containing nanoparticles in serum

Edward R Smith, Tim D Hewitson, Michael MX Cai, Parisa Aghagolzadeh, Matthias Bachtler, Andreas Pasch, Stephen G Holt

Journal article  |  2017  |  Scientific Reports

FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts

Edward R Smith, Sven-Jean Tan, Stephen G Holt, Tim D Hewitson

Journal article  |  2017  |  Scientific Reports

Soluble klotho may be a marker of phosphate reabsorption

Sven-Jean Tan, Edward R Smith, Stephen G Holt, Tim D Hewitson, Nigel D Toussaint

Journal article  |  2017  |  Clinical Kidney Journal

Epigenetic Modifications to H3K9 in Renal Tubulointerstitial Cells after Unilateral Ureteric Obstruction and TGF-beta 1 Stimulation

Timothy D Hewitson, Stephen G Holt, Sven-Jean Tan, Belinda Wigg, Chrishan S Samuel, Edward R Smith

Journal article  |  2017  |  Frontiers in Pharmacology

Mineral adaptations following kidney transplantation

Sven-Jean Tan, Amy Crosthwaite, David Langsford, Varuni Obeysekere, Frank L Ierino, Matthew A Roberts, Peter D Hughes, Tim D Hewitson, Karen M Dwyer, Nigel D Toussaint

Journal article  |  2017  |  Transplant International

Anti-fibrotic actions of relaxin

CS Samuel, SG Royce, TD Hewitson, KM Denton, TE Cooney, RG Bennett

Journal article  |  2017  |  British Journal of Pharmacology

Changes in Markers of Mineral Metabolism After Living Kidney Donation

Sven-Jean Tan, Tim D Hewitson, Peter D Hughes, Stephen G Holt, Nigel D Toussaint

Journal article  |  2017  |  Transplantation Direct

Parenteral iron polymaltose changes i:c-terminal FGF23 ratios in iron deficiency, but not in dialysis patients

S-J Tan, S Satake, ER Smith, ND Toussaint, TD Hewitson, SG Holt

Journal article  |  2017  |  European Journal of Clinical Nutrition

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension

Yeong Hann Ling, Shalini M Krishnan, Christopher T Chan, Henry Diep, Dorota Ferens, Jaye Chin-Dusting, Barbara K Kemp-Harper, Chrishan S Samuel, Timothy D Hewitson, Eicke Latz, Ashley Mansell, Christopher G Sobey, Grant R Drummond

Journal article  |  2017  |  Pharmacological Research

Hypoxia in tissue repair and fibrosis

Ian A Darby, Tim D Hewitson

Journal article  |  2016  |  Cell and Tissue Research

Estrogens do not protect, but androgens exacerbate, collagen accumulation in the female mouse kidney after ureteric obstruction

Tim D Hewitson, Wah Chin Boon, Evan R Simpson, Edward R Smith, Chrishan S Samuel

Journal article  |  2016  |  Life Sciences

Antifiorotic Actions of Serelaxin - New Roles for an Old Player

Chrishan S Samuel, Roger J Summers, Tim D Hewitson

Journal article  |  2016  |  Trends in Pharmacological Sciences

The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate

Chao Wang, Barbara K Kemp-Harper, Martina Kocan, Sheng Yu Ang, Tim D Hewitson, Chrishan S Samuel

Journal article  |  2016  |  Frontiers in Pharmacology

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice

SM Krishnan, JK Dowling, YH Ling, H Diep, CT Chan, D Ferens, MM Kett, A Pinar, CS Samuel, A Vinh, TV Arumugam, TD Hewitson, BK Kemp-Harper, AAB Robertson, MA Cooper, E Latz, A Mansell, CG Sobey, GR Drummond

Journal article  |  2016  |  British Journal of Pharmacology

Kidney Research Experimental Protocols Second Edition Preface

TD Hewitson, ER Smith, SG Holt

Book Chapter  |  2016  |  Methods in Molecular Biology

Qualitative and Quantitative Analysis of Histone Deacetylases in Kidney Tissue Sections

Katherine Ververis, Selly Marzully, Chrishan S Samuel, Tim D Hewitson, Tom C Karagiannis

Book Chapter  |  2016  |  Methods in Molecular Biology

Relationship between timed and spot urine collections for measuring phosphate excretion

Sven-Jean Tan, Edward R Smith, Michael MX Cai, Stephen G Holt, Tim D Hewitson, Nigel D Toussaint

Journal article  |  2016  |  International Urology and Nephrology

Laser Capture Microdissection of Archival Kidney Tissue for qRT-PCR

Tim D Hewitson, Michael Christie, Edward R Smith

Book Chapter  |  2016  |  Methods in Molecular Biology

Propagation and Culture of Human Renal Fibroblasts

Sven-Jean Tan, Tim D Hewitson

Book Chapter  |  2016  |  Methods in Molecular Biology

Animal models to study links between cardiovascular disease and renal failure and their relevance to human pathology

Tim D Hewitson, Stephen G Holt, Edward R Smith

Journal article  |  2015  |  Frontiers in Immunology

Diurnal variation and short-term pre-analytical stability of serum soluble -klotho in healthy volunteers: a pilot study

Sven-Jean Tan, Edward R Smith, Tim D Hewitson, Stephen G Holt, Nigel D Toussaint

Journal article  |  2015  |  Annals of Clinical Biochemistry: An international journal of biochemistry and laboratory medicine

Relative abundance of fetuin- A in peritoneal dialysis effluent and its association with in situ formation of calciprotein particles: An observational pilot study

Michael MX Cai, Belinda Wigg, Edward R Smith, Timothy D Hewitson, Lawrence P McMahon, Stephen G Holt

Journal article  |  2015  |  Nephrology

Qualitative and quantitative analysis of fibrosis in the kidney

Tim D Hewitson, Edward R Smith, Chrishan S Samuel

Journal article  |  2014  |  Nephrology

Serelaxin Is a More Efficacious Antifibrotic Than Enalapril in an Experimental Model of Heart Disease

Chrishan S Samuel, Hasangika Bodaragama, Jacqueline Y Chew, Robert E Widdop, Simon G Royce, Tim D Hewitson

Journal article  |  2014  |  Hypertension

The importance of klotho in phosphate metabolism and kidney disease

Sven-Jean Tan, Edward R Smith, Tim D Hewitson, Stephen G Holt, Nigel D Toussaint

Journal article  |  2014  |  Nephrology

Chronic interstitial nephritis

RG Walker, TD Hewitson, GJ Becker

Book Chapter  |  2014

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

Bryna S Man Chow, Martina Kocan, Sanja Bosnyak, Mohsin Sarwar, Belinda Wigg, Emma S Jones, Robert E Widdop, Roger J Summers, Ross AD Bathgate, Tim D Hewitson, Chrishan S Samuel

Journal article  |  2014  |  Kidney International

Therapeutic Effects of Serelaxin in Acute Heart Failure - Necessity for Bilateral Research Translation

Xiao-Jun Du, Tim D Hewitson, Nguyen My-Nhan, Chrishan S Samuel

Journal article  |  2014  |  Circulation Journal

Nursing research in nephrology: Opportunities and challenges

TD Hewitson

Journal article  |  2014  |  Renal Society of Australasia Journal

Development of second generation peptides modulating cellular adiponectin receptor responses

Laszlo Otvos, Daniel Knappe, Ralf Hoffmann, Ilona Kovalszky, Julia Olah, Tim D Hewitson, Roma Stawikowska, Maciej Stawikowski, Predrag Cudic, Feng Lin, John D Wade, Eva Surmacz, Sandor Lovas

Journal article  |  2014  |  Frontiers in Chemistry

Animal models of chronic kidney disease: useful but not perfect

Gavin J Becker, Tim D Hewitson

Journal article  |  2013  |  Nephrology, Dialysis, Transplantation

The Anti-fibrotic Hormone Relaxin is not Reno-protective, Despite Being Active, in an Experimental Model of Type 1 Diabetes

Su Ee Wong, Chrishan S Samuel, Darren J Kelly, Yuan Zhang, Gavin J Becker, Tim D Hewitson

Journal article  |  2013  |  Protein and Peptide Letters

Relaxin Signals through a RXFP1-pERK-nNOS-NO-cGMP-Dependent Pathway to Up-Regulate Matrix Metalloproteinases: The Additional Involvement of iNOS

Bryna Suet Man Chow, Elaine Guo Yan Chew, Chongxin Zhao, Ross AD Bathgate, Tim D Hewitson, Chrishan S Samuel

Journal article  |  2012  |  PLoS One

Glomerular density and progression

Tim D Hewitson, Gavin J Becker

Journal article  |  2012  |  Nephrology, Dialysis, Transplantation

Long-term mineralocorticoid receptor blockade ameliorates progression of experimental diabetic renal disease

Michael Lian, Tim D Hewitson, Belinda Wigg, Chrishan S Samuel, Fiona Chow, Gavin J Becker

Journal article  |  2012  |  Nephrology, Dialysis, Transplantation

HYPOXIA AND HYPOXIA SIGNALING IN TISSUE REPAIR AND FIBROSIS

Zerina Lokmic, James Musyoka, Timothy D Hewitson, Ian A Darby

Journal article  |  2012  |  International review of cell and molecular biology

Fibrosis in the kidney: is a problem shared a problem halved?

Tim D Hewitson

Journal article  |  2012  |  Fibrogenesis & Tissue Repair

Fibrotic disorders are commonplace, take many forms and can be life-threatening. No better example of this exists than the progres..

Relaxin and Castration in Male Mice Protect from, but Testosterone Exacerbates, Age-Related Cardiac and Renal Fibrosis, Whereas Estrogens Are an Independent Determinant of Organ Size

Tim D Hewitson, Chongxin Zhao, Belinda Wigg, Sin Wai Lee, Evan R Simpson, Wah Chin Boon, Chrishan S Samuel

Journal article  |  2012  |  Endocrinology

Targeted urine microscopy in Anderson-Fabry Disease: a cheap, sensitive and specific diagnostic technique

Mathu Selvarajah, Kathy Nicholls, Tim D Hewitson, Gavin J Becker

Journal article  |  2011  |  Nephrology, Dialysis, Transplantation

Explanting Is an Ex Vivo Model of Renal Epithelial-Mesenchymal Transition

Catherine E Winbanks, Ian A Darby, Kristen J Kelynack, Dodie Pouniotis, Gavin J Becker, Tim D Hewitson

Journal article  |  2011  |  Journal of Biomedicine and Biotechnology

Antifibrotic Properties of Relaxin: In Vivo Mechanism of Action in Experimental Renal Tubulointerstitial Fibrosis

Tim D Hewitson, Wen Yang Ho, Chrishan S Samuel

Journal article  |  2010  |  Endocrinology

The chemically synthesized human relaxin-2 analog, B-R13/17K H2, is an RXFP1 antagonist

Mohammed Akhter Hossain, Chrishan S Samuel, Claudia Binder, Tim D Hewitson, Geoffrey W Tregear, John D Wade, Ross AD Bathgate

Journal article  |  2010  |  Amino Acids

In Situ Localization of Apoptosis Using TUNEL

Tim D Hewitson, Ian A Darby

Journal article  |  2010  |  Methods in molecular biology (Clifton, N.J.)

Lectin Histochemistry for Light and Electron Microscopy

Su Ee Wong, Catherine E Winbanks, Chrishan S Samuel, Tim D Hewitson

Journal article  |  2010  |  Methods in molecular biology (Clifton, N.J.)

Histology Protocols

T HEWITSON, IA Darby

Book Chapter  |  2010

Tissue Preparation for Histochemistry: Fixation, Embedding, and Antigen Retrieval for Light Microscopy

Tim D Hewitson, Belinda Wigg, Gavin J Becker

Journal article  |  2010  |  Methods in molecular biology (Clifton, N.J.)

Phosphate levels-time for a rethink! Reply

Gavin Becker, Rowan Walker, Tim Hewitson, Eugenie Pedagogos

Journal article  |  2009  |  Nephrology Dialysis Transplantation

Aberrant protein expression in plasma and kidney tissue during experimental obstructive nephropathy

Eleni Giannakis, Chrishan S Samuel, Tim D Hewitson, Wee-Ming Boon, Mary Macris, Shane Reeve, Josie Lawrence, A Ian Smith, Geoffrey W Tregear, John D Wade

Journal article  |  2009  |  Proteomics - Clinical Applications

Phosphate levels-time for a rethink?

Gavin J Becker, Rowan G Walker, Timothy D Hewitson, Eugenie Pedagogos

Journal article  |  2009  |  Nephrology, Dialysis, Transplantation

Aldosterone in clinical nephrology-old hormone, new questions

Gavin J Becker, Tim D Hewitson, Anastasia Chrysostomou

Journal article  |  2009  |  Nephrology, Dialysis, Transplantation

Renal tubulointerstitial fibrosis: common but never simple

Tim D Hewitson

Journal article  |  2009  |  American Journal of Physiology: Renal Physiology

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

Ishanee Mookerjee, Tim D Hewitson, Michelle L Halls, Roger J Summers, Michael L Mathai, Ross AD Bathgate, Geoffrey W Tregear, Chrishan S Samuel

Journal article  |  2009  |  FASEB Journal

Kidney Research: Experimental Protocols - Preface

TD Hewitson, GJ Becker

Book  |  2009  |  Methods in Molecular Biology

Relaxin: An Endogenous Renoprotective Factor?

Tim D Hewitson, Chrishan S Samuel

Journal article  |  2009  |  Annals of The New York Academy of Sciences

SELDI-TOF Mass Spectrometry-Based Protein Profiling of Kidney Tissue

Eleni Giannakis, Chrishan S Samuel, Wee-Ming Boon, Mary Macris, Tim D Hewitson, John D Wade

Book Chapter  |  2009  |  Methods in Molecular Biology

Immuno and lectin histochemistry for renal light microscopy.

Tim D Hewitson, Lauren Grimwood

Book Chapter  |  2009  |  Methods in Molecular Biology

Histochemistry is a basic technique in the analysis of cell and tissue biology. Advances in staining techniques have provided the ..

Relaxin and the progression of kidney disease

Chrishan S Samuel, Tim D Hewitson

Journal article  |  2009  |  Current Opinion in Nephrology and Hypertension

Using in situ hybridisation to localize renal gene expression in tissue sections.

Ian A Darby, Alexis Desmoulière, Tim D Hewitson

Book Chapter  |  2009  |  Methods in Molecular Biology

The basics of in situ hybridization have been widely applied to a diverse range of situations where we need to localize the distri..

Small Animal Models of Kidney Disease: A Review

Tim D Hewitson, Takahiko Ono, Gavin J Becker

Book Chapter  |  2009  |  Methods in Molecular Biology

Investigations into the Inhibitory Effects of Relaxin on Renal Myofibroblast Differentiation

Chrishan S Samuel, Ishanee Mookerjee, Michelle L Halls, Roger J Summers, Elaine Chew, Ross AD Bathgate, Geoffrey W Tregear, Tim D Hewitson

Journal article  |  2009  |  Annals of The New York Academy of Sciences

Using In Situ Hybridisation to Localize Renal Gene Expression in Tissue Sections

Ian A Darby, Alexis Desmoulière, Tim D Hewitson

Book Chapter  |  2009  |  Methods in Molecular Biology

Immuno and Lectin Histochemistry for Renal Light Microscopy

Tim D Hewitson, Lauren Grimwood

Book Chapter  |  2009  |  Methods in Molecular Biology

SELDI-TOF mass spectrometry-based protein profiling of kidney tissue.

Eleni Giannakis, Chrishan S Samuel, Wee-Ming Boon, Mary Macris, Tim D Hewitson, John D Wade

Book Chapter  |  2009  |  Methods in Molecular Biology

Protein profiling has numerous applications in renal research including the detection of protein biomarkers with aberrant expressi..

Small animal models of kidney disease: a review.

Tim D Hewitson, Takahiko Ono, Gavin J Becker

Book Chapter  |  2009  |  Methods in Molecular Biology

Animal models of renal disease have provided valuable insights into the pathogenesis of acute and chronic kidney disease. Extensio..

In situ hybridization

IA Darby, TD Hewitson

Book Chapter  |  2008

Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy

Chrishan S Samuel, Tim D Hewitson, Yuan Zhang, Darren J Kelly

Journal article  |  2008  |  Endocrinology

Collecting duct epithelium and injury: Not all cells are created equal

TD Hewitson

Journal article  |  2007  |  Kidney International

Drugs of the future: the hormone relaxin

CS Samuel, TD Hewitson, EN Unemori, ML-K Tang

Journal article  |  2007  |  Cellular and Molecular Life Sciences

Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis

Tim D Hewitson, Ishanee Mookerjee, Rosemary Masterson, Chongxin Zhao, Geoffrey W Tregear, Gavin J Becker, Chrishan S Samuel

Journal article  |  2007  |  Endocrinology

Fibroblast differentiation in wound healing and fibrosis

Ian A Darby, Tim D Hewitson

Journal article  |  2007  |  International Review of Cytology

Role of the phosphatidylinositol 3-kinase and mTOR pathways in the regulation of renal fibroblast function and differentiation

Catherine E Winbanks, Lauren Grimwood, Anna Gasser, Ian A Darby, Tim D Hewitson, Gavin J Becker

Journal article  |  2007  |  International Journal of Biochemistry and Cell Biology

The effects of relaxin and estrogen deficiency on collagen deposition and hypertrophy of nonreproductive organs

Edna D Lekgabe, Simon G Royce, Tim D Hewitson, Mimi LK Tang, Chongxin Zhao, Xiao Lei Moore, Geoffrey W Tregear, Ross AD Bathgate, Xiao-Jun Du, Chrishan S Samuel

Journal article  |  2006  |  Endocrinology

Relaxin in cardiovascular and renal disease

CS Samuel, TD Hewitson

Journal article  |  2006  |  Kidney International

Implementation of a pre-dialysis clinical pathway for patients with chronic kidney disease

JE Owen, RJ Walker, L Edgell, J Collie, L Douglas, TD Hewitson, GJ Becker

Journal article  |  2006  |  International Journal for Quality in Health Care

Effect of inhibition of farnesylation and geranylgeranylation on renal fibrogenesis in vitro

R Masterson, K Kelynack, T Hewitson, G Becker

Journal article  |  2006  |  Nephron Experimental Nephrology

In situ hybridization using cRNA probes: isotopic and nonisotopic detection methods.

Ian A Darby, Teresa Bisucci, Alexis Desmoulière, Tim D Hewitson

Journal article  |  2006  |  Methods in molecular biology (Clifton, N.J.)

In this chapter we describe the use of cRNA (riboprobes) in the detection of gene expression in tissue sections. Riboprobes offer ..

Histochemical localization of cell proliferation using in situ hybridization for histone mRNA.

Tim D Hewitson, Kristen J Kelynack, Ian A Darby

Journal article  |  2006  |  Methods in molecular biology (Clifton, N.J.)

Monoclonal antibodies to proliferation associated antigens have long been used to histologically localize mitogenesis. However, te..

Histochemical localization of apoptosis with in situ labeling of fragmented DNA.

Tim D Hewitson, Teresa Bisucci, Ian A Darby

Journal article  |  2006  |  Methods in molecular biology (Clifton, N.J.)

Cell death by apoptosis is now recognized widely as an important constituent of cell turnover and disease pathology. Characterized..

Impact of statin treatment on 1-year functional and histologic renal allograft outcome

R Masterson, T Hewitson, M Leikis, R Walker, S Cohney, G Becker

Journal article  |  2005  |  Transplantation

Thrombin is a pro-fibrotic factor for rat renal fibroblasts in vitro

TD Hewitson, M Martia, KJ Kelynack, CN Pagel, EJ Mackie, GJ Becker

Journal article  |  2005  |  Nephron Experimental Nephrology

Relaxin regulates collagen overproduction associated with experimental progressive renal fibrosis

CS Samuel, I Mookerjee, R Masterson, GW Tregear, TD Hewitson

Journal article  |  2005  |  Annals of The New York Academy of Sciences

Relaxin-1-deficient mice develop an age-related progression of renal fibrosis

CS Samuel, CX Zhao, CP Bond, TD Hewitson, EP Amento, RJ Summers

Journal article  |  2004  |  Kidney International

Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro

R Masterson, TD Hewitson, K Kelynack, M Martic, L Parry, R Bathgate, I Darby, G Becker

Journal article  |  2004  |  Nephrology, Dialysis, Transplantation

Intracellular cyclic nucleotide analogues inhibit in vitro mitogenesis and activation of fibroblasts derived from obstructed rat kidneys

TD Hewitson, M Martic, IA Darby, KJ Kelynack, T Bisucci, MG Tait, GJ Becker

Journal article  |  2004  |  Experimental Nephrology

Parathyroid hormone has a prosclerotic effect on vascular smooth muscle cells

V Perkovic, TD Hewitson, KJ Kelynack, M Martic, MG Tait, GJ Becker

Journal article  |  2003  |  Kidney & Blood Pressure Research

Dipyridamole inhibits in vitro renal fibroblast proliferation and collagen synthesis

TD Hewitson, MG Tait, KJ Kelynack, M Martic, GJ Becker

Journal article  |  2002  |  Journal of Laboratory and Clinical Medicine

Relaxin down regulates renal fibroblast function and stimulates matrix remodelling in vitro

R Masterson, TD Hewitson, KJ Kelynack, M Martic, L Parry, RA Bathgate, I Darby, GJ Becker

Journal article  |  2002  |  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lovastatin downregulates renal myofibroblast function in vitro

KJ Kelynack, TD Hewitson, M Martic, S McTaggart, GJ Becker

Journal article  |  2002  |  Nephron

Quantitation of in situ hybridization using image analysis of radioactively labeled RNA probes.

T Bisucci, TD Hewitson, IA Darby

Journal article  |  2002  |  Methods in molecular biology (Clifton, N.J.)

Pirfenidone reduces in vitro rat renal fibroblast activation and mitogenesis

TD Hewitson, KJ Kelynack, MG Tait, M Martic, CL Jones, SB Margolin, GJ Becker

Journal article  |  2001  |  Journal of Nephrology

Pharmacological intervention in renal fibrosis and vascular sclerosis

GJ Becker, W Perkovic, TD Hewitson

Journal article  |  2001  |  Journal of Nephrology

Hyaluronan and rat renal fibroblasts: In vitro studies

E Pedagogos, TD Hewitson, KM Nicholls, GJ Becker

Journal article  |  2001  |  Nephron

Simultaneous blockade of endothelin A and B receptors in ischemic acute renal failure is detrimental to long-term kidney function

JM Forbes, TD Hewitson, GJ Becker, CL Jones

Journal article  |  2001  |  Kidney International

Relaxin and renal fibrosis

GJ Becker, TD Hewitson

Journal article  |  2001  |  Kidney International

Endothelin and endothelin A/B receptors are increased after ischaemic acute renal failure

JM Forbes, K Jandeleit-Dahm, TJ Allen, TD Hewitson, GJ Becker, CL Jones

Journal article  |  2001  |  Experimental Nephrology

Human renal fibroblast contraction of collagen I lattices is an integrin-mediated process

KJ Kelynack, TD Hewitson, KM Nicholls, IA Darby, GJ Becker

Journal article  |  2000  |  Nephrology Dialysis Transplantation

Ischemic acute renal failure: Long-term histology of cell and matrix changes in the rat

JM Forbes, TD Hewitson, GJ Becker, CL Jones

Journal article  |  2000  |  Kidney International

The role of tubulointerstitial injury in chronic renal failure

GJ Becker, TD Hewitson

Journal article  |  2000  |  Current Opinion in Nephrology and Hypertension

Pentoxifylline reduces in vitro renal myofibroblast proliferation and collagen secretion

TD Hewitson, M Martic, KJ Kelynack, E Pedagogos, GJ Becker

Journal article  |  2000  |  American Journal of Nephrology

In situ end-labeling of fragmented DNA and the localization of apoptosis.

TD Hewitson, T Bisucci, IA Darby

Journal article  |  2000  |  Methods in molecular biology (Clifton, N.J.)

cRNA probes: comparison of isotopic and nonisotopic detection methods.

T Bisucci, TD Hewitson, IA Darby

Journal article  |  2000  |  Methods in molecular biology (Clifton, N.J.)

Renal myofibroblasts contract collagen I matrix lattices in vitro

KJ Kelynack, TD Hewitson, E Pedagogos, KM Nicholls, GJ Becker

Journal article  |  1999  |  American Journal of Nephrology

Tissue factor pathway inhibitor expression in human crescentic glomerulonephritis

MA Cunningham, T Ono, TD Hewitson, PG Tipping, GJ Becker, SR Holdsworth

Journal article  |  1999  |  Kidney International

Macrophage and myofibroblast involvement in ischemic acute renal failure is attenuated by endothelin receptor antagonists

JM Forbes, B Leaker, TD Hewitson, GJ Becker, CL Jones

Journal article  |  1999  |  Kidney International

Evolution of tubulointerstitial fibrosis in experimental renal infection and scarring

TD Hewitson, IA Darby, T Bisucci, CL Jones, GJ Becker

Journal article  |  1998  |  Journal of the American Society of Nephrology

Cell kinetics and tissue contraction following renal parenchymal cell death

KJ Kelynack, TD Hewitson, KM Nicholls, GJ Becker, CL Jones

Journal article  |  1998  |  Nephrology

Myofibroblast involvement in chronic transplant rejection

E Pedagogos, TD Hewitson, RG Walker, KM Nicholls, GJ Becker

Journal article  |  1997  |  Transplantation

Renal myofibroblasts contract solidified collagen matrix.

K Kelynack, T Hewitson, E Pedagogos, K Nicholls, G Becker

Journal article  |  1997  |  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The interstitium in renal disease

GJ Backer, TD Hewitson

Journal article  |  1997  |  Journal of Internal Medicine

Myofibroblasts and arteriolar sclerosis in human diabetic nephropathy

E Pedagogos, T Hewitson, I Fraser, K Nicholls, G Becker

Journal article  |  1997  |  American Journal of Kidney Diseases

B cell selection and apoptosis in the germinal center.

KGC Smith, TD Hewitson, GJV Nossal, DM Tarlinton

Journal article  |  1997  |  KIDNEY INTERNATIONAL

Apoptosis and resolution of experimental tubulointerstitial nephritis.

TD Hewitson, KGC Smith, GJ Becker

Journal article  |  1997  |  KIDNEY INTERNATIONAL

Myofibroblasts correlate with fibrotic markers in diabetic nephropathy.

E Pedagogos, I Fraser, T Hewitson, K Nicholls, G Becker

Journal article  |  1997  |  KIDNEY INTERNATIONAL

The myofibroblast in acute transplant rejection.

E Pedagogos, T Hewitson, K Nicholls, R Walker, G Becker

Journal article  |  1997  |  KIDNEY INTERNATIONAL

Extracellular matrix remodelling in a wound-like injury to the kidney.

K Kelynack, C Jones, J Forbes, T Hewitson, G Becker

Journal article  |  1997  |  KIDNEY INTERNATIONAL

Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice

IA Darby, T Bisucci, TD Hewitson, DG MacLellan

Journal article  |  1997  |  The International Journal of Biochemistry & Cell Biology

Significance of focal and segmental hyalinosis and sclerosis (FSHS) in IgA nephropathy.

DK Packham, HD Yan, TD Hewitson, KM Nicholls, PS KincaidSmith, GJ Becker

Journal article  |  1996  |  KIDNEY INTERNATIONAL

Interstitial myofibroblasts (MF) in experimental renal infection and scarring.

TD Hewitson, H Wu, GJ Becker

Journal article  |  1996  |  KIDNEY INTERNATIONAL

The significance of focal and segmental hyalinosis and sclerosis (FSHS) and nephrotic range proteinuria in IgA nephropathy

DK Packham, HD Yan, TD Hewitson, KM Nicholls, KF Fairley, P KincaidSmith, GJ Becker

Journal article  |  1996  |  Clinical Nephrology

The tissue inhibitor of the metalloproteinases type I (TIMP-1) in experimental nephrosis.

CL Jones, J Forbes, A HaralambousGasser, K Kelynack, R Walker, T Hewitson, G Becker

Journal article  |  1996  |  KIDNEY INTERNATIONAL

Evolution of interstitial fibrosis in experimental renal infection and scarring.

TD Hewitson, IA Darby, T Bisucci, CL Jones, GJ Becker

Journal article  |  1996  |  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Myofibroblast involvement in renal interstitial fibrosis

T Hewitson, G Becker

Journal article  |  1996  |  Nephrology

Apoptosis and resolution of experimental renal infective tubulointerstitial nephritis

TD Hewitson, KGC Smith, GJ Becker

Journal article  |  1996  |  Nephrology

The phenotype and fate of the antibody-forming cells of the splenic foci

KGC Smith, TD Hewitson, GJV Nossal, DM Tarlinton

Journal article  |  1996  |  European Journal of Immunology

INTERSTITIAL MYOFIBROBLASTS IN EXPERIMENTAL RENAL INFECTION AND SCARRING

TD HEWITSON, HL WU, GJ BECKER

Journal article  |  1995  |  American Journal of Nephrology

APOPTOSIS IN RESOLUTION OF RENAL INFECTIVE TUBULOINTERSTITIAL NEPHRITIS

TD HEWITSON, KGC SMITH, GJ BECKER

Journal article  |  1995  |  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

VASCULAR EXPRESSION OF CLUSTERIN IN EXPERIMENTAL CYCLOSPORINE NEPHROTOXICITY

IA DARBY, T HEWITSON, C JONES, MB FRAENKEL, G BECKER

Journal article  |  1995  |  Experimental Nephrology

INTERSTITIAL MYOFIBROBLASTS IN IGA GLOMERULONEPHRITIS

TD HEWITSON, GJ BECKER

Journal article  |  1995  |  American Journal of Nephrology

ACUTE-RENAL-FAILURE IN IGA NEPHROPATHY

DK PACKHAM, TD HEWITSON, HD YAN, CE ELLIOTT, K NICHOLLS, GJ BECKER

Journal article  |  1994  |  Clinical Nephrology

INTERSTITIAL MYOFIBROBLASTS (MF) ACCUMULATE TRANSIENTLY DURING EXPERIMENTAL RENAL INFECTION AND SCARRING

TD HEWITSON, HL WU, GJ BECKER

Journal article  |  1994  |  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

GLOMERULAR CYST FORMATION BY EXPANSION OF THE SUBENDOTHELIAL SPACE IN EXPERIMENTAL MESANGIOLYSIS

P FARACO, T HEWITSON, P KINCAIDSMITH

Journal article  |  1994  |  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

CLUSTERIN EXPRESSION IN EXPERIMENTAL CYCLOSPORINE-A (CYA) NEPHROTOXICITY

T HEWITSON, IA DARBY, C JONES, M FRAENKEL, G BECKER

Journal article  |  1994  |  KIDNEY INTERNATIONAL

INTERSTITIAL MYOFIBROBLASTS IN IGA GLOMERULONEPHRITIS

TD HEWITSON, GJ BECKER

Journal article  |  1994  |  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

CLINICAL AND HISTOLOGICAL CORRELATIONS OF DECLINE IN RENAL-FUNCTION IN DIABETIC-PATIENTS WITH PROTEINURIA

JL TAFT, CJ NOLAN, SP YEUNG, TD HEWITSON, FIR MARTIN

Journal article  |  1994  |  Diabetes

IGA NEPHROPATHY - CLINICAL-PREDICTION OF OUTCOME

DK PACKHAM, HD YAN, T HEWITSON, PS KINCAIDSMITH, GJ BECKER

Journal article  |  1994  |  KIDNEY INTERNATIONAL

EFFECT OF DIETARY CALCIUM ON THE DEVELOPMENT OF HYPERTENSION AND HYPERTENSIVE VASCULAR-LESIONS IN DOCA-SALT AND 2-KIDNEY, ONE-CLIP HYPERTENSIVE RATS

DT LIU, I BIRCHALL, T HEWITSON, P KINCAIDSMITH, JA WHITWORTH

Journal article  |  1994  |  Journal of hypertension

SUB-THROMBOTIC DOSE OF THROMBIN PRODUCES THROMBI IN THE GLOMERULI OF CYCLOSPORINE (CSA)-TREATED RABBITS

P FARACO, T HEWITSON, P KINCAIDSMITH

Journal article  |  1992  |  KIDNEY INTERNATIONAL

URINARY PLATELET FACTOR-IV (PF4) AND MESANGIAL IGA GLOMERULONEPHRITIS (IGAGN)

K TAIRA, T HEWITSON, P KINCAIDSMITH

Journal article  |  1992  |  KIDNEY INTERNATIONAL

GLOMERULOSCLEROSIS AND HYALINOSIS IN RABBITS

DK PACKHAM, TD HEWITSON, JA WHITWORTH, PS KINCAIDSMITH

Journal article  |  1992  |  Pathology

CORTICOTROPIN EFFECTS ON BLOOD-PRESSURE AND FLUID AND ELECTROLYTE HOMEOSTASIS IN 5 STRAINS OF RATS

JA WHITWORTH, TD HEWITSON, C CORNWALLIS

Journal article  |  1992  |  American Journal of Hypertension

The hemodynamic and metabolic effects of 11 days of sham (saline) and corticotropin injection were examined in five different stra..

REPEATED PREGNANCY DOES NOT ACCELERATE GLOMERULOSCLEROSIS IN RATS WITH SUBTOTAL RENAL ABLATION

B LEAKER, GJ BECKER, M ELKHATIB, TD HEWITSON, PS KINCAIDSMITH

Journal article  |  1992  |  Clinical and Experimental Hypertension. Part B: Hypertension in Pregnancy

URINARY PLATELET FACTOR-IV (PF4) LEVELS IN MESANGIAL IGA GLOMERULONEPHRITIS AND THIN BASEMENT-MEMBRANE DISEASE

K TAIRA, TD HEWITSON, P KINCAIDSMITH

Journal article  |  1992  |  Clinical Nephrology

CAFFEINE POTENTIATION OF MEFENAMIC ACID-INDUCED LESIONS IN THE RAT RENAL MEDULLA

TD HEWITSON, PJC DECRESPIGNY, P KINCAIDSMITH

Journal article  |  1991  |  The Journal of Pathology

ACTH HYPERTENSION IN THE RAT - ROLE OF KIDNEY AND GONADS

JA WHITWORTH, TD HEWITSON

Journal article  |  1991  |  Clinical and Experimental Pharmacology and Physiology

EXPERIMENTAL-MODEL OF THE MICROANGIOPATHIC FORM OF CYCLOSPORINE-A TOXICITY

P FARACO, T HEWITSON, P KINCAIDSMITH

Journal article  |  1991  |  KIDNEY INTERNATIONAL

URINARY PLATELET FACTOR-IV (PF4) LEVELS ARE RAISED IN MESANGIAL IGA GLOMERULONEPHRITIS (IGAGN), BUT NOT IN THIN BASEMENT-MEMBRANE DISEASE (TBMD)

K TAIRA, TD HEWITSON, P KINCAIDSMITH

Journal article  |  1991  |  KIDNEY INTERNATIONAL

AN ANIMAL-MODEL FOR THE STUDY OF THE MICROANGIOPATHIC FORM OF CYCLOSPORINE NEPHROTOXICITY

PR FARACO, TD HEWITSON, P KINCAIDSMITH

Journal article  |  1991  |  Transplantation

ATYPICAL STRUCTURED GLOMERULAR DEPOSITS - AN IMMUNOHISTOCHEMICAL STUDY

M NAKAJIMA, TD HEWITSON, DC MATHEWS, I FORBES, P KINCAIDSMITH

Journal article  |  1991  |  American Journal of Nephrology

UNEXPLAINED HEMATURIA

P KINCAIDSMITH, J OWEN, T HEWITSON

Journal article  |  1991  |  British Medical Journal

LOCALIZATION OF COMPLEMENT COMPONENTS IN ASSOCIATION WITH GLOMERULAR EXTRACELLULAR PARTICLES IN VARIOUS RENAL DISEASES

M NAKAJIMA, TD HEWITSON, DC MATHEWS, P KINCAIDSMITH

Journal article  |  1991  |  Virchows Archiv A Pathological Anatomy and Histopathology

PLATELET-DERIVED GROWTH-FACTOR MESANGIAL DEPOSITS IN MESANGIAL IGA GLOMERULONEPHRITIS

M NAKAJIMA, TD HEWITSON, DC MATHEWS, P KINCAIDSMITH

Journal article  |  1991  |  Nephrology Dialysis Transplantation

PHYSIOLOGICAL AND BIOCHEMICAL EFFECTS OF PREGNANCY IN UNINEPHRECTOMIZED RABBITS

DK PACKHAM, TD HEWITSON, JA WHITWORTH, PS KINCAIDSMITH

Journal article  |  1991  |  Clinical and Experimental Hypertension. Part B: Hypertension in Pregnancy

A COMPARISON OF CAPTOPRIL AND ENALAPRIL IN THE MANAGEMENT OF HYPERTENSION SECONDARY TO RENAL-DISEASE

I MACDONALD, PC DECRESPIGNY, T HEWITSON, P KINCAIDSMITH

Journal article  |  1990  |  KIDNEY INTERNATIONAL

CAFFEINE POTENTIATES THE NEPHROTOXICITY OF MEFENAMIC-ACID ON THE RAT RENAL PAPILLA

PC DECRESPIGNY, T HEWITSON, I BIRCHALL, P KINCAIDSMITH

Journal article  |  1990  |  American Journal of Nephrology

ADRENOCORTICOTROPIN-INDUCED HYPERTENSION IN THE RAT - HEMODYNAMIC, METABOLIC AND MORPHOLOGICAL-CHARACTERISTICS

JA WHITWORTH, TD HEWITSON, L MING, RS WILSON, BA SCOGGINS, RD WRIGHT, P KINCAIDSMITH

Journal article  |  1990  |  Journal of Hypertension

PLATELET FACTOR-4 LABELING OF MESANGIAL DEPOSITS IN MESANGIAL IGA GLOMERULONEPHRITIS

M NAKAJIMA, T HEWITSON, D MATHEWS, P KINCAIDSMITH

Journal article  |  1989  |  KIDNEY INTERNATIONAL

A COMPARISON OF THE VASCULAR AND GLOMERULAR CHANGES IN AORTIC-LIGATURE AND DOCA-SALT HYPERTENSION

TD HEWITSON, H KAMITSUJI, JA WHITWORTH, P KINCAIDSMITH

Journal article  |  1989  |  KIDNEY INTERNATIONAL

PLATELET FACTOR-4 LABELING OF HYALINE DEPOSITS IN ARTERIOLES AND GLOMERULAR CAPILLARIES IN DIABETES

M NAKAJIMA, T HEWITSON, D MATHEWS, P KINCAIDSMITH

Journal article  |  1989  |  KIDNEY INTERNATIONAL

FOCAL AND SEGMENTAL SCLEROSIS IN A RABBIT UNINEPHRECTOMY MODEL - AGGRAVATION BY REPEATED PREGNANCY

D PACKHAM, T HEWITSON, JA WHITWORTH, P KINCAIDSMITH

Journal article  |  1989  |  KIDNEY INTERNATIONAL

MODIFIED IMMUNOGOLD LABELING APPLIED TO THE STUDY OF PROTEIN DROPLETS IN GLOMERULAR-DISEASE

M NAKAJIMA, DC MATHEWS, T HEWITSON, P KINCAIDSMITH

Journal article  |  1989  |  Virchows Archiv A Pathological Anatomy and Histopathology

COMPARISON OF THE VASCULAR AND GLOMERULAR CHANGES IN AORTIC-LIGATURE AND DOCA-SALT HYPERTENSION

T HEWITSON, H KAMITSUJI, JA WHITWORTH, P KINCAIDSMITH

Journal article  |  1989  |  Clinical and Experimental Pharmacology and Physiology

FOCAL AND SEGMENTAL SCLEROSIS IN A RABBIT UNINEPHRECTOMY MODEL - AGGRAVATION BY REPEATED PREGNANCY

D PACKHAM, T HEWITSON, JA WHITWORTH, P KINCAIDSMITH

Journal article  |  1989  |  KIDNEY INTERNATIONAL

GLOMERULAR AND VASCULAR-LESIONS IN DOCA-SALT HYPERTENSION - THE ROLE OF ANTICOAGULATION

T HEWITSON, H KAMITSUJI, JA WHITWORTH, P KINCAIDSMITH

Journal article  |  1988  |  Clinical and Experimental Hypertension. Part A: Theory and Practice