Timothy Hewitson

MO722PHOSPHATE-BINDER THERAPY WITH SUCROFERRIC OXYHYDROXIDE REDUCES ENDOGENOUS CALCIPROTEIN PARTICLE FORMATION AND CRYSTALLIZATION IN A POST-HOC ANALYSIS OF A RANDOMIZED CONTROLLED TRIAL IN DIALYSIS PATIENTS

Ursula Thiem, Tim D Hewitson, Nigel D Toussaint, Maria C Haller, Andreas Pasch, Daniel Cejka, Edward Smith

Journal article  |  2021  |  Nephrology Dialysis Transplantation

Abstract Background and Aims Calcification propensity of serum can be measured..

Effect of a medium cut-off dialyzer on protein-bound uremic toxins and mineral metabolism markers in patients on hemodialysis

Mark K Tiong, Rathika Krishnasamy, Edward R Smith, Colin A Hutchison, Elizabeth G Ryan, Elaine M Pascoe, Carmel M Hawley, Tim D Hewitson, Meg J Jardine, Matthew A Roberts, Yeoungjee Cho, Muh Geot Wong, Anne Heath, Craig L Nelson, Shaundeep Sen, Peter F Mount, Liza A Vergara, Peta-Anne Paul-Brent, David W Johnson, Nigel D Toussaint

Journal article  |  2021  |  HEMODIALYSIS INTERNATIONAL

INTRODUCTION: Hemodialysis (HD) with medium cut-off (MCO) dialyzers may expand molecular clearance, predominantly larger middle mo..

HBEGF: an EGF-like growth factor with FGF23-like activity?

Edward R Smith, Timothy D Hewitson

Journal article  |  2021  |  KIDNEY INTERNATIONAL

Renal signaling networks downstream of FGF23 are not well delineated, but elucidating them may offer an opportunity to control tar..

TGF-beta 1 is a regulator of the pyruvate dehydrogenase complex in fibroblasts

Edward R Smith, Timothy D Hewitson

Journal article  |  2020  |  SCIENTIFIC REPORTS

TGF-β1 reprograms metabolism in renal fibroblasts, inducing a switch from oxidative phosphorylation to aerobic glycolysis. However..

Effect of Sevelamer on Calciprotein Particles in Hemodialysis Patients: The Sevelamer Versus Calcium to Reduce Fetuin-A-Containing Calciprotein Particles in Dialysis (SCaRF) Randomized Controlled Trial

Edward R Smith, Fei Fei M Pan, Tim D Hewitson, Nigel D Toussaint, Stephen G Holt

Journal article  |  2020  |  KIDNEY INTERNATIONAL REPORTS

Introduction: Calciprotein particles (CPPs) are potentially modifiable mediators of phosphate toxicity in patients with kidney dis..

Vascular calcification in skin and subcutaneous tissue in patients with chronic and end-stage kidney disease

Irene Ruderman, Tim D Hewitson, Edward R Smith, Stephen G Holt, Belinda Wigg, Nigel D Toussaint

Journal article  |  2020  |  BMC NEPHROLOGY

BACKGROUND: Vascular calcification (VC) is well described in large- and medium-sized vessels in patients with chronic kidney disea..

Calciprotein particles: mineral behaving badly?

Edward R Smith, Tim D Hewitson, Willi Jahnen-Dechent

Journal article  |  2020  |  CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

PURPOSE OF REVIEW: Calciprotein particles (CPP) are formed in supersaturated solutions of calcium, phosphate and the mineral-bindi..

Monitoring skin temperature at the wrist in hospitalised patients may assist in the detection of infection

Stephen G Holt, Jennifer H Yo, Connie Karschimkus, Frank Volpato, Steve Christov, Edward R Smith, Tim D Hewitson, Leon J Worth, Paul Champion De Crespigny

Journal article  |  2020  |  INTERNAL MEDICINE JOURNAL

BACKGROUND: Measuring temperature has always been a key observation in the diagnosis of infection. No studies have examined the us..

SUN-094 A RANDOMISED CROSS-OVER TRIAL OF THE EFFECTS OF CALCIUM CARBONATE AND SEVELAMER PHOSPHATE BINDERS ON CALCIPROTEIN PARTICLES IN PREVALENT HAEMODIALYSIS PATIENTS

FF Pan, ER Smith, TD Hewitson, B Wigg, PJ Champion de Crespigny, ND Toussaint, SG Holt

Report  |  2020  |  Kidney International Reports

SUN-097 APOA1-MIMETIC PEPTIDES ENHANCE CELLULAR CLEARANCE OF CALCIPROTEIN PARTICLES AND ATTENUATE INFLAMMATORY PRIMING

E Smith, T Hewitson, S Holt

Report  |  2020  |  Kidney International Reports