Timothy Hewitson

TGF-beta 1 is a regulator of the pyruvate dehydrogenase complex in fibroblasts

Edward R Smith, Timothy D Hewitson

Journal article  |  2020  |  Scientific Reports

TGF-β1 reprograms metabolism in renal fibroblasts, inducing a switch from oxidative phosphorylation to aerobic glycolysis. However..

Effect of Sevelamer on Calciprotein Particles in Hemodialysis Patients: The Sevelamer Versus Calcium to Reduce Fetuin-A-Containing Calciprotein Particles in Dialysis (SCaRF) Randomized Controlled Trial

Edward R Smith, Fei Fei M Pan, Tim D Hewitson, Nigel D Toussaint, Stephen G Holt

Journal article  |  2020  |  Kidney International Reports

Vascular calcification in skin and subcutaneous tissue in patients with chronic and end-stage kidney disease

Irene Ruderman, Tim D Hewitson, Edward R Smith, Stephen G Holt, Belinda Wigg, Nigel D Toussaint

Journal article  |  2020  |  BMC Nephrology

BACKGROUND: Vascular calcification (VC) is well described in large- and medium-sized vessels in patients with chronic kidney disea..

Calciprotein particles: mineral behaving badly?

Edward R Smith, Tim D Hewitson, Willi Jahnen-Dechent

Journal article  |  2020  |  Current Opinion in Nephrology & Hypertension

PURPOSE OF REVIEW: Calciprotein particles (CPP) are formed in supersaturated solutions of calcium, phosphate and the mineral-bindi..

Monitoring skin temperature at the wrist in hospitalised patients may assist in the detection of infection

Stephen G Holt, Jennifer H Yo, Connie Karschimkus, Frank Volpato, Steve Christov, Edward R Smith, Tim D Hewitson, Leon J Worth, Paul Champion De Crespigny

Journal article  |  2020  |  Internal Medicine Journal

BACKGROUND: Measuring temperature has always been a key observation in the diagnosis of infection. No studies have examined the us..

SUN-094 A RANDOMISED CROSS-OVER TRIAL OF THE EFFECTS OF CALCIUM CARBONATE AND SEVELAMER PHOSPHATE BINDERS ON CALCIPROTEIN PARTICLES IN PREVALENT HAEMODIALYSIS PATIENTS

FF Pan, ER Smith, TD Hewitson, B Wigg, PJ Champion de Crespigny, ND Toussaint, SG Holt

Report  |  2020  |  Kidney International Reports

SUN-097 APOA1-MIMETIC PEPTIDES ENHANCE CELLULAR CLEARANCE OF CALCIPROTEIN PARTICLES AND ATTENUATE INFLAMMATORY PRIMING

E Smith, T Hewitson, S Holt

Report  |  2020  |  Kidney International Reports

alpha Klotho-FGF23 interactions and their role in kidney disease: a molecular insight

Edward R Smith, Stephen G Holt, Tim D Hewitson

Journal article  |  2019  |  Cellular and Molecular Life Sciences

Following the serendipitous discovery of the ageing suppressor, αKlotho (αKl), several decades ago, a growing body of evidence has..

Diagnostic Tests for Vascular Calcification

Edward R Smith, Tim D Hewitson, Stephen G Holt

Journal article  |  2019  |  Advances in Chronic Kidney Disease

Vascular calcification (VC) is the heterogeneous endpoint of multiple vascular insults, which varies by arterial bed, the layer of..

AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis

Bryna SM Chow, Martina Kocan, Matthew Shen, Yan Wang, Lei Han, Jacqueline Y Chew, Chao Wang, Sanja Bosnyak, Katrina M Mirabito-Colafella, Giannie Barsha, Belinda Wigg, Elizabeth KM Johnstone, Mohammed A Hossain, Kevin DG Pfleger, Kate M Denton, Robert E Widdop, Roger J Summers, Ross AD Bathgate, Tim D Hewitson, Chrishan S Samuel

Journal article  |  2019  |  Journal of the American Society of Nephrology

BACKGROUND: Recombinant human relaxin-2 (serelaxin), which has organ-protective actions mediated via its cognate G protein-coupled..