Damian Myers

1,25(OH)(2)D-3 ameliorates palmitate-induced lipotoxicity in human primary osteoblasts leading to improved viability and function

Ahmed Al Saedi, Damian E Myers, Nicole Stupka, Gustavo Duque

Journal article  |  2020  |  BONE

Contributing to bone loss with aging is a progressive reduction in osteoblast number and function leading to decreased bone format..

Assessment of bone microarchitecture and mineralization changes in an animal model of inflammatory bowel disease using high-resolution synchrotron-based microCT

Damian Myers, Christopher Hall, Ahmed Al Saidi, Ali Ghasem Zadeh, Shilpa Sharma, Sara Vogrin, Rhiannon Filippone, Anton Maksimenko, Daniel Hausermann, Kulmira Nurgali, Gustavo Duque

Conference Proceedings  |  2020  |  JOURNAL OF BONE AND MINERAL RESEARCH

Picolinic Acid, a Catabolite of Tryptophan, Has an Anabolic Effect on Bone In Vivo

Gustavo Duque, Christopher Vidal, Wei Li, Ahmed Al Saedi, Mamdouh Khalil, Chai K Lim, Damian E Myers, Gilles J Guillemin

Journal article  |  2020  |  JOURNAL OF BONE AND MINERAL RESEARCH

Fractures attributable to osteoporosis have a severe impact on our older population. Reports of side effects with commonly prescri..

Rapamycin Affects Palmitate-Induced Lipotoxicity in Osteoblasts by Modulating Apoptosis and Autophagy

Ahmed Al Saedi, Craig A Goodman, Damian E Myers, Alan Hayes, Gustavo Duque

Journal article  |  2020  |  JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Bone marrow fat infiltration is one of the hallmarks of aging and osteoporotic bones. Marrow adipocytes produce substantial amount..

Mechanisms of palmitate-induced lipotoxicity in osteocytes

Ahmed Al Saedi, Sandra Bermeo, Lilian Plotkin, Damian E Myers, Gustavo Duque

Journal article  |  2019  |  BONE

BACKGROUND: Lipotoxicity is defined as cellular toxicity observed in the presence of an abnormal accumulation of fat and adipocyte..

Treatment with an inhibitor of fatty acid synthase attenuates bone loss in ovariectomized mice

Sandra Bermeo, Ahmed Al Saedi, Christopher Vidal, Mamdouh Khalil, Manhui Pang, Bruce R Troen, Damian Myers, Gustavo Duque

Journal article  |  2019  |  BONE

Bone and fat cells have an antagonistic relationship. Adipocytes exert a toxic effect on bone cells in vitro through the secretion..

PICOLINIC ACID (PIC) AS A NOVEL OSTEOANABOLIC: POSSIBLE MECHANISMS OF ACTION

L Singh, A Al-Saedi, E Hassan, D Myers, G Duque

Conference Proceedings  |  2019  |  OSTEOPOROSIS INTERNATIONAL

1,25(OH)D3 ABROGATES PALMITIC ACID-INDUCED LIPOTOXICITY IN NORMAL HUMAN OSTEOBLASTS IN VITRO

AA Al Saedi, DM Myers, SP Phu, GD Duque

Conference Proceedings  |  2019  |  OSTEOPOROSIS INTERNATIONAL

Osteosarcopenia as a Lipotoxic Disease

Ahmed Al Saedi, Craig A Goodman, Damian E Myers, Alan Hayes, Gustavo Duque

Book Chapter  |  2019

Osteosarcopenia, a combination of osteoporosis and sarcopenia is characterized by a synchronic loss of bone mineral density and mu..

Assessment of a new anabolic drug, picolinic acid, in MSC cultures using in vitro live-cell confocal imaging

Damian Myers, Ahmed Al Saedi, Gustavo Duque

Conference Proceedings  |  2018  |  JOURNAL OF BONE AND MINERAL RESEARCH