Lisa Devereux

Multiomic analysis of homologous recombination-deficient end-stage high-grade serous ovarian cancer.

Nikki L Burdett, Madelynne O Willis, Kathryn Alsop, Allison L Hunt, Ahwan Pandey, Phineas T Hamilton, Tamara Abulez, Xuan Liu, Therese Hoang, Stuart Craig, Sian Fereday, Joy Hendley, Dale W Garsed, Katy Milne, Shreena Kalaria, Ashley Marshall, Brian L Hood, Katlin N Wilson, Kelly A Conrads, Kathleen I Pishas, et al.

Journal article  |  2023  |  Nat Genet

High-grade serous ovarian cancer (HGSC) is frequently characterized by homologous recombination (HR) DNA repair deficiency and, wh..

ImmunoPET: IMaging of cancer imMUNOtherapy targets with positron Emission Tomography: a phase 0/1 study characterising PD-L1 with 89Zr-durvalumab (MEDI4736) PET/CT in stage III NSCLC patients receiving chemoradiation study protocol.

Fiona Hegi-Johnson, Stacey E Rudd, Christian Wichmann, Tim Akhurst, Peter Roselt, Jenny Trinh, Thomas John, Lisa Devereux, Paul S Donnelly, Rod Hicks, Andrew M Scott, Daniel Steinfort, Stephen Fox, Benjamin Blyth, Sagun Parakh, Gerard G Hanna, Jason Callahan, Kate Burbury, Michael MacManus

Journal article  |  2022  |  BMJ Open

BACKGROUND: ImmunoPET is a multicentre, single arm, phase 0-1 study that aims to establish if 89Zr-durvalumab PET/CT can be used t..

Somatic inactivation of breast cancer predisposition genes in tumors associated with pathogenic germline variants

Belle WX Lim, Na Li, Sakshi Mahale, Simone M McInerny, Magnus Zethoven, Simone M Rowley, Joanne Huynh, Theresa Wang, Jue Er Amanda Lee, Mia Friedman, Lisa Devereux, Rodney J Scott, Erica K Sloan, Paul A James, Ian G Campbell

Journal article  |  2022  |  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

BACKGROUND: Breast cancers (BCs) that arise in individuals heterozygous for a germline pathogenic variant in a susceptibility gene..

The Clinical and Psychosocial Outcomes for Women Who Received Unexpected Clinically Actionable Germline Information Identified through Research: An Exploratory Sequential Mixed-Methods Comparative Study

Laura E Forrest, Rowan Forbes Shepherd, Erin Tutty, Angela Pearce, Ian Campbell, Lisa Devereux, Alison H Trainer, Paul A James, Mary-Anne Young

Journal article  |  2022  |  JOURNAL OF PERSONALIZED MEDICINE

Background Research identifying and returning clinically actionable germline variants offer a new avenue of access to genetic info..

Abstract 43: Predictive biomarkers of recurrence may not be useful for deescalating treatment of breast ductal carcinoma in situ due to de novo ipsilateral breast carcinoma development

Tanjina Kader, Sakshi Mahale, Magnus Zethoven, Hugo Saunders, Dorothea Lesche, David Byrne, Siqi Lai, Lauren Tjoeka, Claire Candido, Maree Pechlevanis, Olivia Craig, Jia-Min Pang, Lisa Devereux, Shona Hendry, Eloise House, Sureshni Jayasinghe, Michael Toss, Islam M Miligy, Emad Rakha, Stephen Fox, et al.

Journal article  |  2022  |  Cancer Research

Abstract Introduction: Up to 25% of cases of ductal carcinoma in situ (DCIS) recur, and half of these recur as inva..

Contribution of large genomic rearrangements in PALB2 to familial breast cancer: implications for genetic testing

Na Li, Magnus Zethoven, Simone McInerny, Eliza Healey, Dilanka DeSilva, Lisa Devereux, Rodney J Scott, Paul A James, Ian G Campbell

Journal article  |  2022  |  JOURNAL OF MEDICAL GENETICS

BACKGROUND: PALB2 is the most important contributor to familial breast cancer after BRCA1 and BRCA2. Large genomic rearrangements ..

Abstract P3-09-02: Mutational assessment of newly diagnosed breast cancer using Germline and tumor genomICs

Dilanka L De Silva, Anita R Skandarajah, Michelle Sinclair, Maira Kentwell, Lisa Devereux, Magnus Zeethoven, Kirsten Hogg, Luxi Lal, Lesley Stafford, Paul A James, Geoffrey J Lindeman, Gregory B Mann, Ian G Campbell

Journal article  |  2022  |  Cancer Research

Abstract Background :For patients with newly diagnosed breast cancer, real-time identification of pathogenic germli..

Integration of tumour sequencing and case-control data to assess pathogenicity of RAD51C missense variants in familial breast cancer

Belle WX Lim, Na Li, Simone M Rowley, Ella R Thompson, Simone McInerny, Magnus Zethoven, Rodney J Scott, Lisa Devereux, Erica K Sloan, Paul A James, Ian G Campbell

Journal article  |  2022  |  NPJ BREAST CANCER

While protein-truncating variants in RAD51C have been shown to predispose to triple-negative (TN) breast cancer (BC) and ovarian c..

Heterogeneity in how women value risk-stratified breast screening

Jack CW Wheeler, Louise Keogh, Maria A Sierra, Lisa Devereux, Katherine Jones, Maarten J IJzerman, Alison H Trainer

Journal article  |  2022  |  GENETICS IN MEDICINE

PURPOSE: Risk-stratified screening has potential to improve the cost effectiveness of national breast cancer screening programs. T..

Unselected Women's Experiences of Receiving Genetic Research Results for Hereditary Breast and Ovarian Cancer: A Qualitative Study

Rowan Forbes Shepherd, Laura E Forrest, Erin Tutty, Angela Pearce, Lisa Devereux, Paul A James, Ian G Campbell, Alison Trainer, Mary-Anne Young

Journal article  |  2021  |  GENETIC TESTING AND MOLECULAR BIOMARKERS

Background: Although there is growing consensus that clinically actionable genetic research results should be returned to particip..