Dr. Trounce gained his PhD degree from the University of Melbourne in 1991. He held postdoctoral and junior faculty positions at Emory University, Atlanta, in the laboratory of Douglas Wallace before establishing his own laboratory in Australia in 1997.
He is currently Associate Professor in the Center for Eye Research Australia. His expertise is in oxidative phosphorylation, mitochondrial genetics, cell biology and neurobiology. He has made contributions toward understanding mitochondrial disease genetics and oxidative phosphorylation dysfunction, age-related mitochondrial decline, mouse modeling of mitochondrial disease and cybrid modeling of mtDNA diseases. His focus has turned in the past 10 years to mitochondrial contributions to age-related neurodegenerative retinal disease, especially glaucoma.
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Ian Trounce's selected work
OXPHOS bioenergetic compensation does not explain disease penetrance in Leber hereditary o..
Pioglitazone and Deoxyribonucleoside Combination Treatment Increases Mitochondrial Respira..
The Effect Of Sod1 On Mitochondrial Function In Familial Amyotrophic Lateral Sclerosis
Displaying the 4 most recent projects by Ian Trounce.
Displaying the 128 most recent scholarly works by Ian Trounce.
Improvement in inner retinal function in glaucoma with nicotinamide (vitaminB3) supplementation: A crossover randomized clinical trial
Flora Hui, Jessica Tang, Pete A Williams, Myra B McGuinness, Xavier Hadoux, Robert J Casson, Michael Coote, Ian A Trounce, Keith R Martin, Peter van Wijngaarden, Jonathan G Crowston
Journal article | 2020 | Clinical & Experimental Ophthalmology
IMPORTANCE: Retinal ganglion cells endure significant metabolic stress in glaucoma but maintain capacity to recover function. Nico..
OXPHOS bioenergetic compensation does not explain disease penetrance in Leber hereditary optic neuropathy.
M Isabel G Lopez Sanchez, Nicole J Van Bergen, Lisa S Kearns, Mark Ziemann, Helena Liang, Alex W Hewitt, David A Mackey, Ian A Trounce
Journal article | 2020 | Mitochondrion
Leber hereditary optic neuropathy (LHON) is one of the most common primary mitochondrial diseases. It is caused by point mutations..
Pioglitazone and Deoxyribonucleoside Combination Treatment Increases Mitochondrial Respiratory Capacity in m.3243A > G MELAS Cybrid Cells
Harrison J Burgin, M Isabel G Lopez Sanchez, Craig M Smith, Ian A Trounce, Matthew McKenzie
Journal article | 2020 | International Journal of Molecular Sciences
The lack of effective treatments for mitochondrial disease has seen the development of new approaches, including those that aim to..
Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity (vol 56, pg 5471, 2019)
Kathryn Cimdins, Hayley S Waugh, Vicki Chrysostomou, M Isabel G Lopez Sanchez, Vanessa A Johanssen, Mark J Cook, Jonathan G Crowston, Andrew F Hill, James A Duce, Ashley I Bush, Ian A Trounce
Journal article | 2019 | Molecular Neurobiology
Amyloid precursor protein-mediated mitochondrial regulation and Alzheimer's disease
M Isabel G Lopez Sanchez, Peter van Wijngaarden, Ian A Trounce
Journal article | 2019 | British Journal of Pharmacology
Despite clear evidence of a neuroprotective physiological role of amyloid precursor protein (APP) and its non-amyloidogenic proces..
Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity
Kathryn Cimdins, Hayley S Waugh, Vicki Chrysostomou, M Isabel G Lopez Sanchez, Vanessa A Johannsen, Mark J Cook, Jonathan G Crowston, Andrew F Hill, James A Duce, Ashley I Bush, Ian A Trounce
Journal article | 2019 | MOLECULAR NEUROBIOLOGY
Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma
Larry N Singh, Jonathan G Crowston, M Isabel G Lopez Sanchez, Nicole J Van Bergen, Lisa S Kearns, Alex W Hewitt, Seyhan Yazar, David A Mackey, Douglas C Wallace, Ian A Trounce
Journal article | 2018 | Investigative Opthalmology & Visual Science
Protection of the injured optic nerve with forced and voluntary exercise in aged mice: can there be too much of a good thing?
Vicki Chrysostomou, Peter van Wijngaarden, Joseph Paul, Timothy Colgan, Ian A Trounce, Jonathan G Crowston
Conference Proceedings | 2018 | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency
Duncan E Crombie, Claire L Curl, Antonia JA Raaijmakers, Priyadharshini Sivakumaran, Tejal Kulkarni, Raymond CB Wong, Itsunari Minami, Marguerite V Evans-Galea, Shiang Y Lim, Lea Delbridge, Louise A Corben, Mirella Dottori, Norio Nakatsuji, Ian A Trounce, Alex W Hewitt, Martin B Delatycki, Martin F Pera, Alice Pebay
Journal article | 2017 | AGING-US
Mitochondrial replacement in an iPSC model of Leber's hereditary optic neuropathy
Raymond CB Wong, Shiang Y Lim, Sandy SC Hung, Stacey Jackson, Shahnaz Khan, Nicole J Van Bergen, Elisabeth De Smit, Helena H Liang, Lisa S Kearns, Linda Clarke, David A Mackey, Alex W Hewitt, Ian A Trounce, Alice Pebay
Journal article | 2017 | AGING-US
Neuroinflammation in glaucoma: A new opportunity.
Pete A Williams, Nick Marsh-Armstrong, Gareth R Howell, undefined Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants
Journal article | 2017 | Experimental Eye Research
Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the precise roles are not known. Understanding thes..
Mitochondrial DNA haplotypes induce differential patterns of DNA methylation that result in differential chromosomal gene expression patterns
William T Lee, Xin Sun, Te-Sha Tsai, Jacqueline L Johnson, Jodee A Gould, Daniel J Garama, Daniel J Gough, Matthew McKenzie, Ian A Trounce, Justin C St John
Journal article | 2017 | Cell Death Discovery
Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes
Melinda T Coughlan, Nguyen Tuong-Vi, Sally A Penfold, Gavin C Higgins, Vicki Thallas-Bonke, Sih Min Tan, Nicole J Van Bergen, Karly C Sourris, Brooke E Harcourt, David R Thorburn, Ian A Trounce, Mark E Cooper, Josephine M Forbes
Journal article | 2016 | Clinical Science
Study of mitochondrial respiratory defects on reprogramming to human induced pluripotent stem cells
Sandy SC Hung, Nicole J Van Bergen, Stacey Jackson, Helena Liang, David A Mackey, Damian Hernandez, Shiang Y Lim, Alex W Hewitt, Ian Trounce, Alice Pebay, Raymond CB Wong
Journal article | 2016 | AGING-US
Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis
Melinda T Coughlan, Gavin C Higgins, Nguyen Tuong-Vi, Sally A Penfold, Vicki Thallas-Bonke, Sih Mm Tan, Georg Ramm, Nicole J Van Bergen, Darren C Henstridge, Karly C Sourris, Brooke E Harcourt, Ian A Trounce, Portia M Robb, Adrienne Laskowski, Sean L McGee, Amanda J Genders, Ken Walder, Brian G Drew, Paul Gregorevic, Hongwei Qian, et al.
Journal article | 2016 | Diabetes
Characterization of the retinal pigment epithelium in Friedreich ataxia.
Duncan E Crombie, Nicole Van Bergen, Kathryn C Davidson, Sara Anjomani Virmouni, Penny A Mckelvie, Vicki Chrysostomou, Alison Conquest, Louise A Corben, Mark A Pook, Tejal Kulkarni, Ian A Trounce, Martin F Pera, Martin B Delatycki, Alice Pébay
Journal article | 2015 | Biochemistry and Biophysics Reports
We assessed structural elements of the retina in individuals with Friedreich ataxia (FRDA) and in mouse models of FRDA, as well as..
Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy
Nicole J Van Bergen, Jonathan G Crowston, Jamie E Craig, Kathryn P Burdon, Lisa S Kearns, Shiwani Sharma, Alex W Hewitt, David A Mackey, Ian A Trounce
Journal article | 2015 | PLOS ONE
Deficiency in Apoptosis Inducing Factor Recapitulates Diabetic Nephropathy via Aberrant Mitochondrial Homeostasis
Melinda T Coughlan, Gavin C Higgins, Tuong-Vi Nguyen, Sally A Penfold, Vicki Thallas-Bonke, Sih Min Tan, Georg Ramm, Nicole J Van Bergen, Darren C Henstridge, Ian A Trounce, Karly C Sourris, Brooke E Harcourt, Portia M Robb, Adrienne Laskowski, Sean L Mcgee, Ken Walder, Paul Gregorevic, Hongwei Qian, Merlin C Thomas, Brian G Drew, et al.
Conference Proceedings | 2015 | DIABETES
Capture of Somatic mtDNA Point Mutations with Severe Effects on Oxidative Phosphorylation in Synaptosome Cybrid Clones from Human Brain
Matthew McKenzie, Maria Chiotis, Jana Hroudova, Maria IG Lopez Sanchez, Sze Chern Lim, Mark J Cook, Penny McKelvie, Richard GH Cotton, Michael Murphy, Justin C St John, Ian A Trounce
Journal article | 2014 | Human Mutation
Progressive increase in mtDNA 3243A > G heteroplasmy causes abrupt transcriptional reprogramming
Martin Picard, Jiangwen Zhang, Saege Hancock, Olga Derbeneva, Ryan Golhar, Pawel Golik, Sean O'Hearn, Shawn Levy, Prasanth Potluri, Maria Lvova, Antonio Davila, Chun Shi Lin, Juan Carlos Perin, Eric F Rappaport, Hakon Hakonarson, Ian A Trounce, Vincent Procaccio, Douglas C Wallace
Journal article | 2014 | Proceedings of the National Academy of Sciences
Mitochondrial DNA Haplotypes Define Gene Expression Patterns in Pluripotent and Differentiating Embryonic Stem Cells
Richard DW Kelly, Andrew E Rodda, Adam Dickinson, Arsalan Mahmud, Christian M Nefzger, William Lee, John S Forsythe, Jose M Polo, Ian A Trounce, Matthew McKenzie, David R Nisbet, Justin C St John
Journal article | 2013 | Stem Cells
Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
Sebastian Beck Jorgensen, Hayley M O'Neill, Lykke Sylow, Jane Honeyman, Kimberly A Hewitt, Rengasamy Palanivel, Morgan D Fullerton, Lisa Oberg, Anudharan Balendran, Sandra Galic, Chris van der Poel, Ian A Trounce, Gordon S Lynch, Jonathan D Schertzer, Gregory R Steinberg
Journal article | 2013 | Diabetes
Impaired Complex-I-Linked Respiration and ATP Synthesis in Primary Open-Angle Glaucoma Patient Lymphoblasts
Shanjean Lee, Leo Sheck, Jonathan G Crowston, Nicole J Van Bergen, Evelyn C O'Neill, Fleur O'Hare, Yu Xiang George Kong, Vicki Chrysostomou, Andrea L Vincent, Ian A Trounce
Journal article | 2012 | Investigative Ophthalmology and Visual Science
An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copper(II)
Paul S Donnelly, Jeffrey R Liddell, SinChun Lim, Brett M Paterson, Michael A Cater, Maria S Savva, Alexandra I Mot, Janine L James, Ian A Trounce, Anthony R White, Peter J Crouch
Journal article | 2012 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Mitochondrial Oxidative Phosphorylation Compensation May Preserve Vision in Patients with OPA1-Linked Autosomal Dominant Optic Atrophy
Nicole J Van Bergen, Jonathan G Crowston, Lisa S Kearns, Sandra E Staffieri, Alex W Hewitt, Amy C Cohn, David A Mackey, Ian A Trounce
Journal article | 2011 | PLoS One
Mitochondrial disorders and the eye.
Nicole J Van Bergen, Rahul Chakrabarti, Evelyn C O'Neill, Jonathan G Crowston, Ian A Trounce
Journal article | 2011 | Eye and Brain
The clinical significance of disturbed mitochondrial function in the eye has emerged since mitochondrial DNA (mtDNA) mutation was ..
Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation
Peter J Crouch, Deborah J Tew, Tai Du, Diem Ngoc Nguyen, Aphrodite Caragounis, Gulay Filiz, Rachel E Blake, Ian A Trounce, Cynthia PW Soon, Katrina Laughton, Keyla A Perez, Qiao-Xin Li, Robert A Cherny, Colin L Masters, Kevin J Barnham, Anthony R White
Journal article | 2009 | Journal of Neurochemistry
Use of transmitochondrial cybrids to assign a complex I defect to the mitochondrial DNA-encoded NADH dehydrogenase subunit 6 gene mutation at nucleotide pair 14459 that causes Leber hereditary optic neuropathy and dystonia
AS Jun, IA Trounce, MD Brown, JM Shoffner, DC Wallace
Journal article | 1996 | Molecular and Cellular Biology
CYTOPLASMIC TRANSFER OF THE MTDNA NT-8993-T-]G (ATP6) POINT MUTATION ASSOCIATED WITH LEIGH-SYNDROME INTO MTDNA-LESS CELLS DEMONSTRATES COSEGREGATION WITH A DECREASE IN STATE-III RESPIRATION AND ADP/O RATIO
I TROUNCE, S NEILL, DC WALLACE
Journal article | 1994 | Proceedings of the National Academy of Sciences
FUNCTIONAL RESPIRATORY-CHAIN STUDIES IN MITOCHONDRIAL CYTOPATHIES - SUPPORT FOR MITOCHONDRIAL-DNA HETEROPLASMY IN MYOCLONUS EPILEPSY AND RAGGED RED FIBERS (MERRF) SYNDROME
E BYRNE, I TROUNCE, S MARZUKI, X DENNETT, SF BERKOVIC, S DAVIS, M TANAKA, T OZAWA
Journal article | 1991 | Acta Neuropathologica
Melbourne Medical School
Medicine - St Vincent'S Hospital
Ophthalmology Eye And Ear Hospital
Bachelor of Science
University of Melbourne
Doctor of Philosophy
University of Melbourne