Ian Trounce

Role of extracellular vesicles in mitochondrial eye diseases

Sushma Anand, Ian A Trounce, Lahiru Gangoda

Journal article  |  2022  |  IUBMB LIFE

Extracellular vesicles (EVs) are small packages that are released by almost all types of cells. While the role of EVs in pathogene..

MitoScape: A big-data, machine-learning platform for obtaining mitochondrial DNA from next-generation sequencing data

Larry N Singh, Brian Ennis, Bryn Loneragan, Noah L Tsao, M Isabel G Lopez Sanchez, Jianping Li, Patrick Acheampong, Oanh Tran, Ian A Trounce, Yuankun Zhu, Prasanth Potluri, Beverly S Emanuel, Daniel J Rader, Zoltan Arany, Scott M Damrauer, Adam C Resnick, Stewart A Anderson, Douglas C Wallace

Journal article  |  2021  |  PLOS COMPUTATIONAL BIOLOGY

The growing number of next-generation sequencing (NGS) data presents a unique opportunity to study the combined impact of mitochon..

Nuclear response to divergent mitochondrial DNA genotypes modulates the interferon immune response

M Isabel G Lopez Sanchez, Mark Ziemann, Annabell Bachem, Rahul Makam, Jonathan G Crowston, Carl A Pinkert, Matthew McKenzie, Sammy Bedoui, Ian A Trounce

Journal article  |  2020  |  PLOS ONE

Mitochondrial OXPHOS generates most of the energy required for cellular function. OXPHOS biogenesis requires the coordinated expre..

OXPHOS bioenergetic compensation does not explain disease penetrance in Leber hereditary optic neuropathy

M Isabel G Lopez Sanchez, Nicole J Van Bergen, Lisa S Kearns, Mark Ziemann, Helena Liang, Alex W Hewitt, David A Mackey, Ian A Trounce

Journal article  |  2020  |  MITOCHONDRION

Leber hereditary optic neuropathy (LHON) is one of the most common primary mitochondrial diseases. It is caused by point mutations..

Improvement in inner retinal function in glaucoma with nicotinamide (vitaminB3) supplementation: A crossover randomized clinical trial

Flora Hui, Jessica Tang, Pete A Williams, Myra B McGuinness, Xavier Hadoux, Robert J Casson, Michael Coote, Ian A Trounce, Keith R Martin, Peter van Wijngaarden, Jonathan G Crowston

Journal article  |  2020  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

IMPORTANCE: Retinal ganglion cells endure significant metabolic stress in glaucoma but maintain capacity to recover function. Nico..

Pioglitazone and Deoxyribonucleoside Combination Treatment Increases Mitochondrial Respiratory Capacity in m.3243A > G MELAS Cybrid Cells

Harrison J Burgin, M Isabel G Lopez Sanchez, Craig M Smith, Ian A Trounce, Matthew McKenzie

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The lack of effective treatments for mitochondrial disease has seen the development of new approaches, including those that aim to..

Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity (vol 56, pg 5471, 2019)

Kathryn Cimdins, Hayley S Waugh, Vicki Chrysostomou, M Isabel G Lopez Sanchez, Vanessa A Johanssen, Mark J Cook, Jonathan G Crowston, Andrew F Hill, James A Duce, Ashley I Bush, Ian A Trounce

Journal article  |  2019  |  MOLECULAR NEUROBIOLOGY

The original version of this article unfortunately contained a mistake in the author name. The family name of Dr. Vanessa A. Johan..

Amyloid precursor protein-mediated mitochondrial regulation and Alzheimer's disease

M Isabel G Lopez Sanchez, Peter van Wijngaarden, Ian A Trounce

Journal article  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

Despite clear evidence of a neuroprotective physiological role of amyloid precursor protein (APP) and its non-amyloidogenic proces..

Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity

Kathryn Cimdins, Hayley S Waugh, Vicki Chrysostomou, M Isabel G Lopez Sanchez, Vanessa A Johannsen, Mark J Cook, Jonathan G Crowston, Andrew F Hill, James A Duce, Ashley I Bush, Ian A Trounce

Journal article  |  2019  |  MOLECULAR NEUROBIOLOGY

Mitochondrial complex I dysfunction is the most common respiratory chain defect in human disorders and a hotspot for neurodegenera..

Visual recovery as the target for glaucoma

V Chrysostomou, RJ Hatch, T Colgan, JP Paul, P van Wijngaarden, I Trounce, MIG Lopez Sanchez, K Bell, F Grus, JG Crowston

Journal article  |  2019  |  OPHTHALMOLOGE

BACKGROUND: Visual recovery is an established but poorly studied phenomenon in glaucoma. OBJECTIVE: To provide insights into funct..