Ian Trounce

Improvement in inner retinal function in glaucoma with nicotinamide (vitaminB3) supplementation: A crossover randomized clinical trial

Flora Hui, Jessica Tang, Pete A Williams, Myra B McGuinness, Xavier Hadoux, Robert J Casson, Michael Coote, Ian A Trounce, Keith R Martin, Peter van Wijngaarden, Jonathan G Crowston

Journal article  |  2020  |  Clinical & Experimental Ophthalmology

IMPORTANCE: Retinal ganglion cells endure significant metabolic stress in glaucoma but maintain capacity to recover function. Nico..

OXPHOS bioenergetic compensation does not explain disease penetrance in Leber hereditary optic neuropathy.

M Isabel G Lopez Sanchez, Nicole J Van Bergen, Lisa S Kearns, Mark Ziemann, Helena Liang, Alex W Hewitt, David A Mackey, Ian A Trounce

Journal article  |  2020  |  Mitochondrion

Leber hereditary optic neuropathy (LHON) is one of the most common primary mitochondrial diseases. It is caused by point mutations..

Pioglitazone and Deoxyribonucleoside Combination Treatment Increases Mitochondrial Respiratory Capacity in m.3243A > G MELAS Cybrid Cells

Harrison J Burgin, M Isabel G Lopez Sanchez, Craig M Smith, Ian A Trounce, Matthew McKenzie

Journal article  |  2020  |  International Journal of Molecular Sciences

The lack of effective treatments for mitochondrial disease has seen the development of new approaches, including those that aim to..

Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity (vol 56, pg 5471, 2019)

Kathryn Cimdins, Hayley S Waugh, Vicki Chrysostomou, M Isabel G Lopez Sanchez, Vanessa A Johanssen, Mark J Cook, Jonathan G Crowston, Andrew F Hill, James A Duce, Ashley I Bush, Ian A Trounce

Journal article  |  2019  |  Molecular Neurobiology

Amyloid precursor protein-mediated mitochondrial regulation and Alzheimer's disease

M Isabel G Lopez Sanchez, Peter van Wijngaarden, Ian A Trounce

Journal article  |  2019  |  British Journal of Pharmacology

Despite clear evidence of a neuroprotective physiological role of amyloid precursor protein (APP) and its non-amyloidogenic proces..

Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity

Kathryn Cimdins, Hayley S Waugh, Vicki Chrysostomou, M Isabel G Lopez Sanchez, Vanessa A Johannsen, Mark J Cook, Jonathan G Crowston, Andrew F Hill, James A Duce, Ashley I Bush, Ian A Trounce

Journal article  |  2019  |  MOLECULAR NEUROBIOLOGY

Visual recovery as the target for glaucoma

V Chrysostomou, RJ Hatch, T Colgan, JP Paul, P van Wijngaarden, I Trounce, MIG Lopez Sanchez, K Bell, F Grus, JG Crowston

Journal article  |  2019  |  Der Ophthalmologe

Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma

Larry N Singh, Jonathan G Crowston, M Isabel G Lopez Sanchez, Nicole J Van Bergen, Lisa S Kearns, Alex W Hewitt, Seyhan Yazar, David A Mackey, Douglas C Wallace, Ian A Trounce

Journal article  |  2018  |  Investigative Opthalmology & Visual Science

Mitochondria, exercise, diet and the aging retina

Ian A Trounce

Conference Proceedings  |  2018  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Protection of the injured optic nerve with forced and voluntary exercise in aged mice: can there be too much of a good thing?

Vicki Chrysostomou, Peter van Wijngaarden, Joseph Paul, Timothy Colgan, Ian A Trounce, Jonathan G Crowston

Conference Proceedings  |  2018  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

M Isabel G Lopez Sanchez, Hayley S Waugh, Andrew Tsatsanis, Bruce X Wong, Jonathan G Crowston, James A Duce, Ian A Trounce

Journal article  |  2017  |  SCIENTIFIC REPORTS

Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency

Duncan E Crombie, Claire L Curl, Antonia JA Raaijmakers, Priyadharshini Sivakumaran, Tejal Kulkarni, Raymond CB Wong, Itsunari Minami, Marguerite V Evans-Galea, Shiang Y Lim, Lea Delbridge, Louise A Corben, Mirella Dottori, Norio Nakatsuji, Ian A Trounce, Alex W Hewitt, Martin B Delatycki, Martin F Pera, Alice Pebay

Journal article  |  2017  |  AGING-US

Mitochondrial replacement in an iPSC model of Leber's hereditary optic neuropathy

Raymond CB Wong, Shiang Y Lim, Sandy SC Hung, Stacey Jackson, Shahnaz Khan, Nicole J Van Bergen, Elisabeth De Smit, Helena H Liang, Lisa S Kearns, Linda Clarke, David A Mackey, Alex W Hewitt, Ian A Trounce, Alice Pebay

Journal article  |  2017  |  AGING-US

Neuroinflammation in glaucoma: A new opportunity.

Pete A Williams, Nick Marsh-Armstrong, Gareth R Howell, undefined Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants

Journal article  |  2017  |  Experimental Eye Research

Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the precise roles are not known. Understanding thes..

Relief for retinal neurons under pressure

Jonathan Crowston, Ian Trounce

Journal article  |  2017  |  Science

Targeting retinal ganglion cell recovery

JG Crowston, ET Fahy, L Fry, IA Trounce, P van Wijngaarden, S Petrou, V Chrysostomou

Journal article  |  2017  |  Eye

Mitochondrial DNA haplotypes induce differential patterns of DNA methylation that result in differential chromosomal gene expression patterns

William T Lee, Xin Sun, Te-Sha Tsai, Jacqueline L Johnson, Jodee A Gould, Daniel J Garama, Daniel J Gough, Matthew McKenzie, Ian A Trounce, Justin C St John

Journal article  |  2017  |  Cell Death Discovery

Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway

Vicki Chrysostomou, Sandra Galic, Peter van Wijngaarden, Ian A Trounce, Gregory R Steinberg, Jonathan G Crowston

Journal article  |  2016  |  Aging Cell

Emerging Mitochondrial Therapeutic Targets in Optic Neuropathies

MIG Lopez Sanchez, JG Crowston, DA Mackey, IA Trounce

Journal article  |  2016  |  Pharmacology & Therapeutics

Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly

Sze Chern Lim, Jana Hroudova, Nicole J Van Bergen, M Isabel G Lopez Sanchez, Ian A Trounce, Matthew McKenzie

Journal article  |  2016  |  The FASEB Journal

Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes

Melinda T Coughlan, Nguyen Tuong-Vi, Sally A Penfold, Gavin C Higgins, Vicki Thallas-Bonke, Sih Min Tan, Nicole J Van Bergen, Karly C Sourris, Brooke E Harcourt, David R Thorburn, Ian A Trounce, Mark E Cooper, Josephine M Forbes

Journal article  |  2016  |  Clinical Science

Study of mitochondrial respiratory defects on reprogramming to human induced pluripotent stem cells

Sandy SC Hung, Nicole J Van Bergen, Stacey Jackson, Helena Liang, David A Mackey, Damian Hernandez, Shiang Y Lim, Alex W Hewitt, Ian Trounce, Alice Pebay, Raymond CB Wong

Journal article  |  2016  |  AGING-US

Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis

Melinda T Coughlan, Gavin C Higgins, Nguyen Tuong-Vi, Sally A Penfold, Vicki Thallas-Bonke, Sih Mm Tan, Georg Ramm, Nicole J Van Bergen, Darren C Henstridge, Karly C Sourris, Brooke E Harcourt, Ian A Trounce, Portia M Robb, Adrienne Laskowski, Sean L McGee, Amanda J Genders, Ken Walder, Brian G Drew, Paul Gregorevic, Hongwei Qian, et al.

Journal article  |  2016  |  Diabetes

Segregation of Naturally Occurring Mitochondrial DNA Variants in a Mini-Pig Model

Gael Cagnone, Te-Sha Tsai, Kanokwan Srirattana, Fernando Rossello, David R Powell, Gary Rohrer, Lynsey Cree, Ian A Trounce, Justin C St John

Journal article  |  2016  |  Genetics

Generation of Xenomitochondrial Embryonic Stem Cells for the Production of Live Xenomitochondrial Mice

Ian A Trounce, Jessica Ackerley, Matthew McKenzie

Journal article  |  2016  |  Methods in molecular biology (Clifton, N.J.)

Characterization of the retinal pigment epithelium in Friedreich ataxia.

Duncan E Crombie, Nicole Van Bergen, Kathryn C Davidson, Sara Anjomani Virmouni, Penny A Mckelvie, Vicki Chrysostomou, Alison Conquest, Louise A Corben, Mark A Pook, Tejal Kulkarni, Ian A Trounce, Martin F Pera, Martin B Delatycki, Alice Pébay

Journal article  |  2015  |  Biochemistry and Biophysics Reports

We assessed structural elements of the retina in individuals with Friedreich ataxia (FRDA) and in mouse models of FRDA, as well as..

An acute intraocular pressure challenge to assess retinal ganglion cell injury and recovery in the mouse

Jonathan G Crowston, Yu Xiang G Kong, Ian A Trounce, Trung M Dang, Eamonn T Fahy, Bang V Bui, John C Morrison, Vicki Chrysostomou

Journal article  |  2015  |  Experimental Eye Research

Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy

Nicole J Van Bergen, Jonathan G Crowston, Jamie E Craig, Kathryn P Burdon, Lisa S Kearns, Shiwani Sharma, Alex W Hewitt, David A Mackey, Ian A Trounce

Journal article  |  2015  |  PLOS ONE

Deficiency in Apoptosis Inducing Factor Recapitulates Diabetic Nephropathy via Aberrant Mitochondrial Homeostasis

Melinda T Coughlan, Gavin C Higgins, Tuong-Vi Nguyen, Sally A Penfold, Vicki Thallas-Bonke, Sih Min Tan, Georg Ramm, Nicole J Van Bergen, Darren C Henstridge, Ian A Trounce, Karly C Sourris, Brooke E Harcourt, Portia M Robb, Adrienne Laskowski, Sean L Mcgee, Ken Walder, Paul Gregorevic, Hongwei Qian, Merlin C Thomas, Brian G Drew, et al.

Conference Proceedings  |  2015  |  DIABETES

Capture of Somatic mtDNA Point Mutations with Severe Effects on Oxidative Phosphorylation in Synaptosome Cybrid Clones from Human Brain

Matthew McKenzie, Maria Chiotis, Jana Hroudova, Maria IG Lopez Sanchez, Sze Chern Lim, Mark J Cook, Penny McKelvie, Richard GH Cotton, Michael Murphy, Justin C St John, Ian A Trounce

Journal article  |  2014  |  Human Mutation

Progressive increase in mtDNA 3243A > G heteroplasmy causes abrupt transcriptional reprogramming

Martin Picard, Jiangwen Zhang, Saege Hancock, Olga Derbeneva, Ryan Golhar, Pawel Golik, Sean O'Hearn, Shawn Levy, Prasanth Potluri, Maria Lvova, Antonio Davila, Chun Shi Lin, Juan Carlos Perin, Eric F Rappaport, Hakon Hakonarson, Ian A Trounce, Vincent Procaccio, Douglas C Wallace

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

Forced exercise protects the aged optic nerve against intraocular pressure injury

Vicki Chrysostomou, Jelena M Kezic, Ian A Trounce, Jonathan G Crowston

Journal article  |  2014  |  Neurobiology of Aging

Modifying Mitochondrial Genetics

CA Pinkert, MH Irwin, K Takeda, IA Trounce

Book Chapter  |  2014

Mitochondrial dysfunction and complications associated with diabetes

Rachel Blake, Ian A Trounce

Journal article  |  2014  |  Biochimica et Biophysica Acta - General Subjects

Amyloid precursor protein protects against a rodent model of optic neuropathy and is abundant in the human vitreous

Hayley Waugh, Vicki Chrysostomou, Jonathan G Crowston, Ian Trounce

Conference Proceedings  |  2014  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Mitochondrial Impairments in Primary Open Angle Glaucoma Patient Lymphoblasts

Nicole J Van Bergen, Jamie E Craig, Alex W Hewitt, Kathryn P Burdon, Shiwani Sharma, Jonathan G Crowston, Ian V Trounce

Conference Proceedings  |  2014  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Oxidative phosphorylation measurement in cell lines and tissues

Nicole J Van Bergen, Rachel E Blake, Jonathan G Crowston, Ian A Trounce

Journal article  |  2014  |  Mitochondrion

Mitochondria in Retinal Neurodegeneration and Stem Cell Models

Ian A Trounce

Book Chapter  |  2014

EXERCISE PROTECTS THE AGED RETINA AGAINST INJURY

Vicki Chrysostomou, Jelena M Kezic, Ian A Trounce, Jonathan G Crowston

Conference Proceedings  |  2013  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

MITOCHONDRIAL IMPARIMENTS IN PRIMARY OPEN ANGLE GLAUCOMA PATIENT LYMPHOBLASTS

Nicole Van Bergen, Shanjean Lee, Leo Sheck, Evelyn C O'Neill, Fleur O'Hare, Andrea L Vincent, Jonathan G Crowston, Ian A Trounce

Conference Proceedings  |  2013  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

MITOCHONDRIAL IMPAIRMENT AND VULNERABILITY OF THE OPTIC NERVE TO INJURY

Ian A Trounce, Nicole Van Bergen, Vicki Chrysostomou, Rachel Blake, Jonathan Crowston

Conference Proceedings  |  2013  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

AGEING AND OPTIC NERVE VULNERABILITY TO INJURY

Jonathan Crowston, Vicki Chrysostomou, Nicole Van Bergen, Eamonn Fahy, Ian Trounce

Conference Proceedings  |  2013  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Modulation of ceramide-induced cell death and superoxide production by mitochondrial DNA-encoded respiratory chain defects in Rattus xenocybrid mouse cells

Ian A Trounce, Peter J Crouch, Kirstyn T Carey, Matthew McKenzie

Journal article  |  2013  |  Biochimica et Biophysica Acta. Bioenergetics

Effect of Anterior Chamber Cannulation and Acute IOP Elevation on Retinal Macrophages in the Adult Mouse

Jelena M Kezic, Vicki Chrysostomou, Ian A Trounce, Paul G McMenamin, Jonathan G Crowston

Journal article  |  2013  |  Investigative Ophthalmology and Visual Science

Mitochondrial DNA Haplotypes Define Gene Expression Patterns in Pluripotent and Differentiating Embryonic Stem Cells

Richard DW Kelly, Andrew E Rodda, Adam Dickinson, Arsalan Mahmud, Christian M Nefzger, William Lee, John S Forsythe, Jose M Polo, Ian A Trounce, Matthew McKenzie, David R Nisbet, Justin C St John

Journal article  |  2013  |  Stem Cells

The Effects of Nuclear Reprogramming on Mitochondrial DNA Replication

Richard DW Kelly, Huseyin Sumer, Matthew McKenzie, Joao Facucho-Oliveira, Ian A Trounce, Paul J Verma, Justin C St John

Journal article  |  2013  |  STEM CELL REVIEWS AND REPORTS

Oxidative stress and mitochondrial dysfunction in glaucoma

Vicki Chrysostomou, Fatemeh Rezania, Ian A Trounce, Jonathan G Crowston

Journal article  |  2013  |  Current Opinion in Pharmacology

Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity

Sebastian Beck Jorgensen, Hayley M O'Neill, Lykke Sylow, Jane Honeyman, Kimberly A Hewitt, Rengasamy Palanivel, Morgan D Fullerton, Lisa Oberg, Anudharan Balendran, Sandra Galic, Chris van der Poel, Ian A Trounce, Gordon S Lynch, Jonathan D Schertzer, Gregory R Steinberg

Journal article  |  2013  |  Diabetes

Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A

Richard DW Kelly, Arsalan Mahmud, Matthew McKenzie, Ian A Trounce, Justin C St John

Journal article  |  2012  |  Nucleic Acids Research

Impact of aging and diet restriction on retinal function during and after acute intraocular pressure injury

Yu Xiang George Kong, Nicole van Bergen, Bang V Bui, Vicki Chrysostomou, Algis J Vingrys, Ian A Trounce, Jonathan G Crowston

Journal article  |  2012  |  Neurobiology of Aging

Impaired Complex-I-Linked Respiration and ATP Synthesis in Primary Open-Angle Glaucoma Patient Lymphoblasts

Shanjean Lee, Leo Sheck, Jonathan G Crowston, Nicole J Van Bergen, Evelyn C O'Neill, Fleur O'Hare, Yu Xiang George Kong, Vicki Chrysostomou, Andrea L Vincent, Ian A Trounce

Journal article  |  2012  |  Investigative Ophthalmology and Visual Science

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copper(II)

Paul S Donnelly, Jeffrey R Liddell, SinChun Lim, Brett M Paterson, Michael A Cater, Maria S Savva, Alexandra I Mot, Janine L James, Ian A Trounce, Anthony R White, Peter J Crouch

Journal article  |  2012  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Auditory processing deficits in individuals with primary open-angle glaucoma

Gary Rance, Fleur O'Hare, Stephen O'Leary, Arnold Starr, Anna Ly, Belinda Cheng, Dani Tomlin, Kelley Graydon, Donella Chisari, Ian Trounce, Jonathan Crowston

Journal article  |  2012  |  International Journal of Audiology

Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury

Yu XG Kong, Nicole Van Bergen, Ian A Trounce, Bang V Bui, Vicki Chrysostomou, Hayley Waugh, Algis Vingrys, Jonathan G Crowston

Journal article  |  2011  |  AGING CELL

Mitochondrial dysfunction in glaucoma and emerging bioenergetic therapies

Shanjean Lee, Nicole J Van Bergen, George Y Kong, Vicki Chrysostomou, Hayley S Waugh, Evelyn C O'Neill, Jonathan G Crowston, Ian A Trounce

Journal article  |  2011  |  Experimental Eye Research

Mitochondrial Oxidative Phosphorylation Compensation May Preserve Vision in Patients with OPA1-Linked Autosomal Dominant Optic Atrophy

Nicole J Van Bergen, Jonathan G Crowston, Lisa S Kearns, Sandra E Staffieri, Alex W Hewitt, Amy C Cohn, David A Mackey, Ian A Trounce

Journal article  |  2011  |  PLoS One

Xenomitochondrial mice: Investigation into mitochondrial compensatory mechanisms

MV Cannon, DA Dunn, MH Irwin, AI Brooks, FF Bartol, IA Trounce, CA Pinkert

Journal article  |  2011  |  Mitochondrion

Mitochondrial disorders and the eye.

Nicole J Van Bergen, Rahul Chakrabarti, Evelyn C O'Neill, Jonathan G Crowston, Ian A Trounce

Journal article  |  2011  |  Eye and Brain

The clinical significance of disturbed mitochondrial function in the eye has emerged since mitochondrial DNA (mtDNA) mutation was ..

Antifibrotic Activity of Bevacizumab on Human Tenon's Fibroblasts In Vitro

Evelyn C O'Neill, Queena Qin, Nicole J Van Bergen, Paul P Connell, Sushil Vasudevan, Michael A Coote, Ian A Trounce, Tina TL Wong, Jonathan G Crowston

Journal article  |  2010  |  Investigative Ophthalmology and Visual Science

MITOCHONDRIAL IMPAIRMENT RESULTS IN INCREASED SUSCEPTIBILITY TO INJURY IN RETINAL NEURONS

George Yu Xiang Kong, Ian Trounce, Bang Bui, Nicole Van Bergen, Vicki Chrysostomou, Hayley Waugh, Algis Vingrys, Jonathan Crowston

Conference Proceedings  |  2010  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Early hippocampal oxidative stress is a direct consequence of seizures in the rapid electrical amygdala kindling model

Maithili Sashindranath, Karen J McLean, Ian A Trounce, Richard GH Cotton, Mark J Cook

Journal article  |  2010  |  Epilepsy Research

GENETICS Optic nerve genetics-more than meets the eye

David A Mackey, Ian Trounce

Journal article  |  2010  |  Nature Reviews Neurology

The optic nerve head in acquired optic neuropathies

Evelyn C O'Neill, Helen V Danesh-Meyer, Paul P Connell, Ian A Trounce, Michael A Coote, David A Mackey, Jonathan G Crowston

Journal article  |  2010  |  Nature Reviews Neurology

Enzymatic and Chemical Cleavage Methods to Identify Genetic Variation

Chinh T Bui, Emmanuelle Nicolas, Georgina Sallmann, Maria Chiotis, Andreana Lambrinakos, Kylee Rees, Ian Trounce, Richard GH Cotton, Lauryn Blakesley, Andrew K Godwin, Anthony T Yeung

Book Chapter  |  2010

Mechanisms of Retinal Ganglion Cell Injury in Aging and Glaucoma

Vicki Chrysostomou, Ian A Trounce, Jonathan G Crowston

Journal article  |  2010  |  Ophthalmic Research: journal for research in experimental and clinical ophthalmology

Functional Changes in the Retina during and after Acute Intraocular Pressure Elevation in Mice

Yu X Kong, Jonathan G Crowston, Algis J Vingrys, Ian A Trounce, Bang V Bui

Journal article  |  2009  |  Investigative Ophthalmology and Visual Science

Recharacterization of the RGC-5 Retinal Ganglion Cell Line

Nicole J Van Bergen, John PM Wood, Glyn Chidlow, Ian A Trounce, Robert J Casson, Won-Kyu Ju, Robert N Weinreb, Jonathan G Crowston

Journal article  |  2009  |  Investigative Ophthalmology and Visual Science

The Role of Glia, Mitochondria, and the Immune System in Glaucoma

Guelguen Tezel

Journal article  |  2009  |  Investigative Ophthalmology and Visual Science

Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation

Peter J Crouch, Deborah J Tew, Tai Du, Diem Ngoc Nguyen, Aphrodite Caragounis, Gulay Filiz, Rachel E Blake, Ian A Trounce, Cynthia PW Soon, Katrina Laughton, Keyla A Perez, Qiao-Xin Li, Robert A Cherny, Colin L Masters, Kevin J Barnham, Anthony R White

Journal article  |  2009  |  Journal of Neurochemistry

Mitochondrial Dysfunction and Glaucoma

George YX Kong, Nicole J Van Bergen, Ian A Trounce, Jonathan G Crowston

Journal article  |  2009  |  Journal of Glaucoma

The mitochondrial genome sequence of Mus terricolor: Comparison with Mus musculus domesticus and implications for xenomitochondrial mouse modeling

Wendy K Pogozelski, Leah D Fletcher, Carolyn A Cassar, David A Dunn, Ian A Trounce, Carl A Pinkert

Journal article  |  2008  |  Gene

Generation of rho(0) cells utilizing a mitochondrially targeted restriction endonuclease and comparative analyses

Alexandra Kukat, Christian Kukat, Jan Brocher, Ingo Schaefer, Georg Krohne, Ian A Trounce, Gaetano Villani, Peter Seibel

Journal article  |  2008  |  Nucleic Acids Research

The Role of PI3/Akt Pathway in the Protective Effect of Insulin against Corticosterone Cell Death Induction in Hippocampal Cell Culture

Maryam Moosavi, Nader Maghsoudi, Saleh Zahedi-Asl, Nasser Naghdi, Mitra Yousefpour, Ian Andrew Trounce

Journal article  |  2008  |  Neuroendocrinology

Mitochondria in aging and Alzheimer's disease

PJ Crouch, K Cimdins, JA Duce, AI Bush, IA Trounce

Journal article  |  2007  |  Rejuvenation Research

Generation of transmitochondrial mice: Development of xenomitochondrial mice to model neurodegenerative diseases

Carl A Pinkert, Ian A Trounce

Book Chapter  |  2007  |  Methods in Cell Biology

Cybrid models of mtDNA disease and transmission, from cells to mice

Ian A Trounce, Carl A Pinkert

Book  |  2007  |  Current Topics in Developmental Biology

Copper-dependent inhibition of cytochrome c oxidase by A beta(1-42) requires reduced methionine at residue 35 of the A beta peptide

Peter J Crouch, Kevin J Barnham, James A Duce, Rachel E Blake, Colin L Masters, Ian A Trounce

Journal article  |  2006  |  Journal of Neurochemistry

Linker histone H1 binds to disease associated amyloid-like fibrils

James A Duce, David P Smith, Rachel E Blake, Peter J Crouch, Qiao-Xin Li, Colin L Masters, Ian A Trounce

Journal article  |  2006  |  Journal of Molecular Biology

Is the mitochondrion the target of seizure induced oxidative damage?

M Sashindranath, KJ McLean, IA Trounce, RGH Cotton, MJ Cook

Conference Proceedings  |  2005  |  JOURNAL OF THE NEUROLOGICAL SCIENCES

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta(1-42)

PJ Crouch, R Blake, JA Duce, GD Ciccotosto, QX Li, KJ Barnham, CC Curtain, RA Cherny, R Cappai, T Dyrks, CL Masters, IA Trounce

Journal article  |  2005  |  Journal of Neuroscience

Animal modeling: From transgenesis to transmitochondrial models

CA Pinkert, IA Trounce

Book Chapter  |  2005

Enzymatic and chemical cleavage methods to dientify genetic variation

CT BUI, E NICOLAS, M CHIOTIS, IA TROUNCE, R COTTON, G SALLMANN, A LAMBRINAKOS, K REES, L BLAKESLEY, A GODWIN, AT YEUNG

Book Chapter  |  2005

Cybrids in the study of animal mitochondrial genetics and pathology

IA Trounce, CA Pinkert

Book Chapter  |  2005

Seizure induced oxidative damage in the amygdala kindling model of epilepsy

M Sashindranath, KJ McLean, IA Trounce, RGH Cotton, MJ Cook

Conference Proceedings  |  2005  |  EPILEPSIA

Xenomitochondrial embryonic stem cells and mice: Modeling human mitochondrial biology and disease

MV Cannon, CA Pinkert, IA Trounce

Journal article  |  2004  |  Gene Therapy and Regulation

Development and initial characterization of xenomitochondrial mice

IA Trounce, M McKenzie, CA Cassar, CA Ingraham, CA Lerner, DA Dunn, CL Donegan, K Takeda, WK Pogozelski, RL Howell, CA Pinkert

Journal article  |  2004  |  Journal of Bioenergetics and Biomembranes

Production of homoplasmic xenomitochondrial mice

M McKenzie, IA Trounce, CA Cassar, CA Pinkert

Journal article  |  2004  |  Proceedings of the National Academy of Sciences of the United States of America

Transgenic animals: modifying the mitochondrial genome.

CA PINKERT, LC SMITH, IA TROUNCE

Book Chapter  |  2004

Functional respiratory chain analyses in murid xenomitochondrial cybrids expose coevolutionary constraints of cytochrome b and nuclear subunits of complex III

M McKenzie, M Chiotis, CA Pinkert, IA Trounce

Journal article  |  2003  |  Molecular Biology and Evolution

Pathoetiology of motor neuron disease: new insights from genetics and animal models

I Trounce, S Feeney, E Byrne

Journal article  |  2003  |  Journal of Clinical Neuroscience

Flow cytometry in the study of mitochondrial respiratory chain disorders

K Setterfield, AJ Williams, J Donald, DR Thorburn, DM Kirby, I Trounce, J Christodoulou

Journal article  |  2002  |  Mitochondrion

Production of transmitochondrial mice

CA Pinkert, IA Trounce

Journal article  |  2002  |  Methods

Functional analysis of lymphoblast and cybrid mitochondria containing the 3460, 11778, or 14484 Leber's hereditary optic neuropathy mitochondrial DNA mutation

MD Brown, IA Trounce, AS Jun, JC Allen, DC Wallace

Journal article  |  2000  |  Journal of Biological Chemistry

Expression of Rattus norvegicus mtDNA in Mus musculus cells results in multiple respiratory chain defects

M McKenzie, I Trounce

Journal article  |  2000  |  Journal of Biological Chemistry

Genetic control of oxidative phosphorylation and experimental models of defects.

I Trounce

Conference Proceedings  |  2000  |  Human Reproduction

Energy in the form of ATP is continually produced by all cells for normal growth and function. Anaerobic glycolysis can provide en..

Cloning of neuronal mtDNA variants in cultured cells by synaptosome fusion with mtDNA-less cells

I Trounce, J Schmiedel, HC Yen, S Hosseini, MD Brown, JJ Olson, DC Wallace

Journal article  |  2000  |  Nucleic Acids Research

A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator

BH Graham, KG Waymire, B Cottrell, IA Trounce, GR MacGregor, DC Wallace

Journal article  |  1997  |  Nature Genetics

Use of transmitochondrial cybrids to assign a complex I defect to the mitochondrial DNA-encoded NADH dehydrogenase subunit 6 gene mutation at nucleotide pair 14459 that causes Leber hereditary optic neuropathy and dystonia

AS Jun, IA Trounce, MD Brown, JM Shoffner, DC Wallace

Journal article  |  1996  |  Molecular and Cellular Biology

Production of transmitochondrial mouse cell lines by cybrid rescue of rhodamine-6G pre-treated L-cells

I Trounce, DC Wallace

Journal article  |  1996  |  Somatic Cell and Molecular Genetics

Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines.

IA Trounce, YL Kim, AS Jun, DC Wallace

Journal article  |  1996  |  Methods in Enzymology

MITOCHONDRIAL-DNA MUTATIONS IN HUMAN DEGENERATIVE DISEASES AND AGING

DC WALLACE, JM SHOFFNER, I TROUNCE, MD BROWN, SW BALLINGER, M CORRALDEBRINSKI, T HORTON, AS JUN, MT LOTT

Journal article  |  1995  |  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Mitochondrial diseases and aging

DC Wallace, MT Lott, I Trounce, MD Brown, K Huoponen, N Krawiecki, JM Shoffner

Conference Proceedings  |  1995  |  THIRTY YEARS OF PROGRESS IN MITOCHONDRIAL BIOENERGETICS AND MOLECULAR BIOLOGY

CYTOPLASMIC TRANSFER OF THE MTDNA NT-8993-T-]G (ATP6) POINT MUTATION ASSOCIATED WITH LEIGH-SYNDROME INTO MTDNA-LESS CELLS DEMONSTRATES COSEGREGATION WITH A DECREASE IN STATE-III RESPIRATION AND ADP/O RATIO

I TROUNCE, S NEILL, DC WALLACE

Journal article  |  1994  |  Proceedings of the National Academy of Sciences

A MITOCHONDRIAL-DNA VARIANT, IDENTIFIED IN LEBER HEREDITARY OPTIC NEUROPATHY PATIENTS, WHICH EXTENDS THE AMINO-ACID-SEQUENCE OF CYTOCHROME-C-OXIDASE SUBUNIT-I

MD BROWN, CC YANG, I TROUNCE, A TORRONI, MT LOTT, DC WALLACE

Journal article  |  1992  |  American Journal of Human Genetics

MATERNALLY TRANSMITTED DIABETES AND DEAFNESS ASSOCIATED WITH A 10.4 KB MITOCHONDRIAL-DNA DELETION

SW BALLINGER, JM SHOFFNER, EV HEDAYA, I TROUNCE, MA POLAK, DA KOONTZ, DC WALLACE

Journal article  |  1992  |  Nature Genetics

MITOCHONDRIAL THEORY OF SENESCENCE - RESPIRATORY-CHAIN PROTEIN STUDIES IN HUMAN SKELETAL-MUSCLE

E BYRNE, I TROUNCE, X DENNETT

Journal article  |  1991  |  Mechanisms of Ageing and Development

AFFINITY-CHROMATOGRAPHY ISOLATION OF HUMAN CYTOCHROME-OXIDASE AND SMALL-SCALE WESTERN IMMUNOBLOT PROBING OF THE ENZYME COMPLEX IN MITOCHONDRIAL CYTOPATHY PATIENTS

I TROUNCE, E BYRNE, X DENNETT, WW CHEN, S MARZUKI

Journal article  |  1991  |  Biochemical Medicine and Metabolic Biology

FUNCTIONAL RESPIRATORY-CHAIN STUDIES IN SUBJECTS WITH CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA AND LARGE HETEROPLASMIC MITOCHONDRIAL-DNA DELETIONS

I TROUNCE, E BYRNE, S MARZUKI, X DENNETT, H SUDOYO, F MASTAGLIA, SF BERKOVIC

Journal article  |  1991  |  Journal of the Neurological Sciences

FUNCTIONAL RESPIRATORY-CHAIN STUDIES IN MITOCHONDRIAL CYTOPATHIES - SUPPORT FOR MITOCHONDRIAL-DNA HETEROPLASMY IN MYOCLONUS EPILEPSY AND RAGGED RED FIBERS (MERRF) SYNDROME

E BYRNE, I TROUNCE, S MARZUKI, X DENNETT, SF BERKOVIC, S DAVIS, M TANAKA, T OZAWA

Journal article  |  1991  |  Acta Neuropathologica

OXIDATIVE ENERGY FAILURE IN POSTMITOTIC CELLS - A MAJOR FACTOR IN SENESCENCE

E BYRNE, X DENNETT, I TROUNCE

Conference Proceedings  |  1991  |  Revue Neurologique

BIOCHEMICAL AND MORPHOLOGICAL-STUDIES OF SKELETAL-MUSCLE IN EXPERIMENTAL CHRONIC-ALCOHOLIC MYOPATHY

I TROUNCE, E BYRNE, X DENNETT

Journal article  |  1990  |  Acta Neurologica Scandinavica

ANTIMITOCHONDRIAL AUTOANTIBODIES OF PRIMARY BILIARY-CIRRHOSIS AS A NOVEL PROBE IN THE STUDY OF 2-OXO ACID DEHYDROGENASES IN PATIENTS WITH MITOCHONDRIAL MYOPATHIES

H SUDOYO, S MARZUKI, I TROUNCE, E BYRNE

Journal article  |  1990  |  Journal of the Neurological Sciences

DECLINE IN SKELETAL-MUSCLE MITOCHONDRIAL RESPIRATORY-CHAIN FUNCTION - POSSIBLE FACTOR IN AGING

I TROUNCE, E BYRNE, S MARZUKI

Journal article  |  1989  |  LANCET

Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing.

I Trounce, E Byrne, S Marzuki

Journal article  |  1989  |  The Lancet

State III (activated) mitochondrial respiration rates with pyruvate/malate, glutamate/malate, and succinate as substrates were ass..

PROGRESSION FROM MERRF TO MELAS PHENOTYPE IN A PATIENT WITH COMBINED RESPIRATORY COMPLEX-I AND COMPLEX-IV DEFICIENCIES

E BYRNE, I TROUNCE, X DENNETT, B GILLIGAN, JB MORLEY, S MARZUKI

Journal article  |  1988  |  Journal of the Neurological Sciences

Mitochondrial DNA deletion in encephalomyopathy.

AS Noer, S Marzuki, I Trounce, E Byrne

Journal article  |  1988  |  The Lancet

MITOCHONDRIAL-DNA DELETION IN ENCEPHALOMYOPATHY

AS NOER, S MARZUKI, I TROUNCE, E BYRNE

Journal article  |  1988  |  LANCET

PROTEIN-SYNTHESIS IN MITOCHONDRIA ISOLATED FROM HUMAN SKELETAL-MUSCLE - DETECTION OF POLYMORPHISM IN MITOCHONDRIAL TRANSLATION PRODUCTS

S MARZUKI, N SATTAYASAI, I TROUNCE, E BYRNE

Journal article  |  1988  |  Journal of the Neurological Sciences

MITOCHONDRIAL-FUNCTION IN KEARNS-SAYRE SYNDROME - REPLY

E BYRNE, S MARZUKI, N SATTAYASAI, X DENNETT, I TROUNCE

Journal article  |  1988  |  Neurology

MITOCHONDRIAL ENCEPHALOPATHIES, MELAS, MERRF, OR A SPECTRUM

E BYRNE, I TROUNCE, X DENNETT, JB MORLEY, B GILLIGAN

Conference Proceedings  |  1988  |  AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE

MITOCHONDRIAL STUDIES IN KEARNS-SAYRE SYNDROME - NORMAL RESPIRATORY-CHAIN FUNCTION WITH ABSENCE OF A MITOCHONDRIAL TRANSLATION PRODUCT

E BYRNE, S MARZUKI, N SATTAYASAI, X DENNETT, I TROUNCE

Journal article  |  1987  |  Neurology

CHRONIC-ALCOHOLIC PROXIMAL WASTING - PHYSIOLOGICAL, MORPHOLOGICAL AND BIOCHEMICAL-STUDIES IN SKELETAL-MUSCLE

I TROUNCE, E BYRNE, X DENNETT, J SANTAMARIA, J DOERY, R PEPPARD

Journal article  |  1987  |  Australian and New Zealand Journal of Medicine

CHRONIC FATIGUE AND MYALGIA SYNDROME - MITOCHONDRIAL AND GLYCOLYTIC STUDIES IN SKELETAL-MUSCLE

E BYRNE, I TROUNCE

Journal article  |  1987  |  Journal of Neurology, Neurosurgery & Psychiatry

DOMINANTLY INHERITED CARDIOSKELETAL MYOPATHY WITH LYSOSOMAL GLYCOGEN-STORAGE AND NORMAL ACID MALTASE LEVELS

E BYRNE, X DENNETT, B CROTTY, I TROUNCE, JM SANDS, R HAWKINS, J HAMMOND, S ANDERSON, EA HAAN, A POLLARD

Journal article  |  1986  |  Brain

PARTIAL CYTOCHROME-OXIDASE (AA3) DEFICIENCY IN CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA - HISTOCHEMICAL AND BIOCHEMICAL-STUDIES

E BYRNE, X DENNETT, I TROUNCE, R HENDERSON

Journal article  |  1985  |  Journal of the Neurological Sciences

MITOCHONDRIAL MYONEUROPATHY WITH RESPIRATORY-FAILURE AND MYOCLONIC EPILEPSY - A CASE-REPORT WITH BIOCHEMICAL-STUDIES

E BYRNE, X DENNETT, I TROUNCE, J BURDON

Journal article  |  1985  |  Journal of the Neurological Sciences

CHRONIC RELAPSING MYALGIA (QUESTIONABLE POST VIRAL) - CLINICAL, HISTOLOGICAL, AND BIOCHEMICAL-STUDIES

E BYRNE, I TROUNCE, X DENNETT

Journal article  |  1985  |  Australian and New Zealand Journal of Medicine

OXYGEN-ELECTRODE STUDIES WITH HUMAN SKELETAL-MUSCLE MITOCHONDRIA INVITRO - A RE-APPRAISAL

E BYRNE, I TROUNCE

Journal article  |  1985  |  Journal of the Neurological Sciences