Ian Trounce

Nuclear response to divergent mitochondrial DNA genotypes modulates the interferon immune response

M Isabel G Lopez Sanchez, Mark Ziemann, Annabell Bachem, Rahul Makam, Jonathan G Crowston, Carl A Pinkert, Matthew McKenzie, Sammy Bedoui, Ian A Trounce

Journal article  |  2020  |  PLoS One

Mitochondrial OXPHOS generates most of the energy required for cellular function. OXPHOS biogenesis requires the coordinated expre..

OXPHOS bioenergetic compensation does not explain disease penetrance in Leber hereditary optic neuropathy

M Isabel G Lopez Sanchez, Nicole J Van Bergen, Lisa S Kearns, Mark Ziemann, Helena Liang, Alex W Hewitt, David A Mackey, Ian A Trounce

Journal article  |  2020  |  Mitochondrion

Leber hereditary optic neuropathy (LHON) is one of the most common primary mitochondrial diseases. It is caused by point mutations..

Improvement in inner retinal function in glaucoma with nicotinamide (vitaminB3) supplementation: A crossover randomized clinical trial

Flora Hui, Jessica Tang, Pete A Williams, Myra B McGuinness, Xavier Hadoux, Robert J Casson, Michael Coote, Ian A Trounce, Keith R Martin, Peter van Wijngaarden, Jonathan G Crowston

Journal article  |  2020  |  Clinical and Experimental Ophthalmology

IMPORTANCE: Retinal ganglion cells endure significant metabolic stress in glaucoma but maintain capacity to recover function. Nico..

Improvement in inner retinal function in glaucoma in response to nicotinamide (Vitamin B3) supplementation: a crossover randomized clinical trial

Flora Hui, Jessica Tang, Pete Williams, Myra McGuinness, Xavier Hadoux, Robert James Casson, Michael Coote, Ian Trounce, Keith R Martin, Peter van Wijngaarden, Jonathan Guy Crowston

Conference Proceedings  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Importance: Retinal ganglion cells endure significant metabolic stress with ageing and glaucoma-related stressors. Injured cells r..

Pioglitazone and Deoxyribonucleoside Combination Treatment Increases Mitochondrial Respiratory Capacity in m.3243A > G MELAS Cybrid Cells

Harrison J Burgin, M Isabel G Lopez Sanchez, Craig M Smith, Ian A Trounce, Matthew McKenzie

Journal article  |  2020  |  International Journal of Molecular Sciences

The lack of effective treatments for mitochondrial disease has seen the development of new approaches, including those that aim to..

Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity (vol 56, pg 5471, 2019)

Kathryn Cimdins, Hayley S Waugh, Vicki Chrysostomou, M Isabel G Lopez Sanchez, Vanessa A Johanssen, Mark J Cook, Jonathan G Crowston, Andrew F Hill, James A Duce, Ashley I Bush, Ian A Trounce

Journal article  |  2019  |  Molecular Neurobiology

Amyloid precursor protein-mediated mitochondrial regulation and Alzheimer's disease

M Isabel G Lopez Sanchez, Peter van Wijngaarden, Ian A Trounce

Journal article  |  2019  |  British Journal of Pharmacology

Despite clear evidence of a neuroprotective physiological role of amyloid precursor protein (APP) and its non-amyloidogenic proces..

Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity

Kathryn Cimdins, Hayley S Waugh, Vicki Chrysostomou, M Isabel G Lopez Sanchez, Vanessa A Johannsen, Mark J Cook, Jonathan G Crowston, Andrew F Hill, James A Duce, Ashley I Bush, Ian A Trounce

Journal article  |  2019  |  MOLECULAR NEUROBIOLOGY

Visual recovery as the target for glaucoma

V Chrysostomou, RJ Hatch, T Colgan, JP Paul, P van Wijngaarden, I Trounce, MIG Lopez Sanchez, K Bell, F Grus, JG Crowston

Journal article  |  2019  |  Der Ophthalmologe

Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma

Larry N Singh, Jonathan G Crowston, M Isabel G Lopez Sanchez, Nicole J Van Bergen, Lisa S Kearns, Alex W Hewitt, Seyhan Yazar, David A Mackey, Douglas C Wallace, Ian A Trounce

Journal article  |  2018  |  Investigative Ophthalmology and Visual Science