Fay Khong

Transcriptomic analysis of choroidal neovascularization reveals dysregulation of immune and fibrosis pathways that are attenuated by a novel anti-fibrotic treatment

Alice Brandli, Fay L Khong, Roy CK Kong, Darren J Kelly, Erica L Fletcher

Journal article  |  2022  |  SCIENTIFIC REPORTS

Neovascular AMD (nAMD) leads to vision loss and is a leading cause of visual impairment in the industrialised world. Current treat..

NP202 treatment improves left ventricular systolic function and attenuates pathological remodelling following chronic myocardial infarction

Andrew R Kompa, Fay L Khong, Yuan Zhang, Cindy Nguyen, Amanda J Edgley, Owen L Woodman, Grant McLachlan, Darren J Kelly

Journal article  |  2021  |  LIFE SCIENCES

AIMS: Myocardial injury is a major contributor to left ventricular (LV) remodelling activating neurohormonal and inflammatory proc..

Oral delivery of the anti-fibrotic, FT011, achieves safe and robust intraocular levels of exposure in subjects undergoing glaucoma filtration surgery

Jennifer Fan Gaskin, Nathan Kerr, Michelle Pauline Papadimitriou, Roy Chze Khai Kong, Fay Lin Khong, Darren Kelly

Conference Proceedings  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Oral delivery of a novel small molecule drug, OCX063, protects against vascular leakage and fibrosis in a rodent model of neovascular age-related macular degeneration

Michelle Pauline Papadimitriou, Zsolt Ablonczy, Andy Whitlock, Erica Fletcher, Fay Lin Khong, Darren Kelly

Conference Proceedings  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

OCX063, a novel small molecule drug, is protective against inflammatory, fibrotic and angiogenic phenotypes in retinal cultures

Roy Chze Khai Kong, Elsa Chan, Alison J Cox, Sylwia Glowacka, Fay Lin Khong, Michelle Pauline Papadimitriou, Darren Kelly

Conference Proceedings  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Oral administration of the novel small molecule drug OCX063 protects against inflammation and vascular pathology in a rat diabetic retinopathy (DR) model

Roy Chze Khai Kong, Amanda Edgley, Elsa Chan, Alison J Cox, Sylwia Glowacka, Michelle Papadimitriou, Fay Lin Khong, Darren Kelly

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

NP202 Attenuates Left Ventricular Systolic Dysfunction and Pathological Remodelling Following Myocardial Infarction

A Kompa, F Khong, C Nguyen, Y Zhang, A Edgley, G McLachlan, D Kelly

Journal article  |  2018  |  Heart, Lung and Circulation

OCX063, A Novel Small Molecule Drug, Exhibits Anti-Inflammatory and Anti-Fibrotic Properties in Retinal Cultures

Roy Chze Khai Chze Khai Kong, Alison J Cox, Sylwia Glowacka, Darren J Kelly, Fay Khong

Conference Proceedings  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

The protective effect of OCX063 on reducing neovascularization and lesion size in a mouse model of choroidal neovascularization.

Erica L Fletcher, Alice A Brandli, Roy Kong, Fay Khong, Darren J Kelly

Conference Proceedings  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

FT011, a Novel Cardiorenal Protective Drug, Reduces Inflammation, Gliosis and Vascular Injury in Rats with Diabetic Retinopathy

Devy Deliyanti, Yuan Zhang, Fay Khong, David R Berka, David I Stapleton, Darren J Kelly, Jennifer L Wilkinson-Berka

Journal article  |  2015  |  PLOS ONE

Diabetic retinopathy features inflammation as well as injury to glial cells and the microvasculature, which are influenced by hype..