Professor John Bateman is the Director of the Cell Biology Theme at the Murdoch Childrens Research Institute, and Head of the Skeletal Biology and Disease Research Group and is a Professorial Fellow of the University of Melbourne. His research interests include the molecular mechanisms of extracellular matrix protein assembly in health and disease and molecular genetics of musculoskeletal disease.
A major focus of current research involves using mouse models of bone and cartilage disease to explore the fundamental disease mechanisms. Recently his laboratory has developed proteomic and RNA expression profiling approaches to study cartilage development and disease including osteoarthritis.
He has over 160 peer-reviewed publication and is an NHMRC Senior Principal Research Fellow.
He has served on the Editorial Boards of several journals including The Journal of Biological Chemistry; The Biochemical Journal, Matrix Biology. He is a Past-President of International Society of Matrix Biology and Matrix Biology of Australia and New Zealand. He is a member of the NHMRC Academy (Cell Biology and Biochemistry).
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John Bateman's selected work
Generation of a heterozygous COL2A1 (p.R989C) spondyloepiphyseal dysplasia congenita mutat..
Generation of a SOX9-tdTomato reporter human iPSC line, MCRIi001-A-2, using CRISPR/Cas9 ed..
Displaying the 7 most recent projects by John Bateman.
Displaying the 197 most recent scholarly works by John Bateman.
Generation of a heterozygous COL2A1 (p.R989C) spondyloepiphyseal dysplasia congenita mutation iPSC line, MCRIi001-B, using CRISPR/Cas9 gene editing
Jinia Lilianty, Yudha Nur Patria, Edouard G Stanley, Andrew G Elefanty, John F Bateman, Shireen R Lamande
Journal article | 2020 | Stem Cell Research
To produce an in vitro model of the human chondrodysplasia, spondyloepiphyseal dysplasia congenita, we used CRISPR/Cas9 gene editi..
Generation of a SOX9-tdTomato reporter human iPSC line, MCRIi001-A-2, using CRISPR/Cas9 editing
Yudha Nur Patria, Jinia Lilianty, Andrew G Elefanty, Edouard G Stanley, Tanya Labonne, John F Bateman, Shireen R Lamande
Journal article | 2020 | Stem Cell Research
To develop an iPSC SOX9 reporter line for monitoring differentiation into SOX9 expressing cells such as chondrocytes, cranial neur..
Identification of Two Independent COL5A1 Variants in Dogs with Ehlers-Danlos Syndrome
Anina Bauer, John F Bateman, Shireen R Lamande, Eric Hanssen, Shannon GM Kirejczyk, Mark Yee, Ali Ramiche, Vidyha Jagannathan, Monika Welle, Tosso Leeb, Fiona L Bateman
Journal article | 2019 | Genes
The Ehlers-Danlos syndromes (EDS) are a heterogeneous group of heritable disorders affecting connective tissues. The mutations cau..
Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis.
Louise HW Kung, Lorna Mullan, Jamie Soul, Ping Wang, Kazutoshi Mori, John F Bateman, Michael D Briggs, Raymond P Boot-Handford
Journal article | 2019 | Arthritis Research & Therapy
BACKGROUND: Osteoarthritis has been associated with a plethora of pathological factors and one which has recently emerged is chond..
XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease
Katarzyna A Pirog, Ella P Dennis, Claire L Hartley, Robert M Jackson, Jamie Soul, Jean-Marc Schwartz, John F Bateman, Raymond P Boot-Handford, Michael D Briggs
Journal article | 2019 | PLOS Genetics
The unfolded protein response (UPR) is a conserved cellular response to the accumulation of proteinaceous material in endoplasmic ..
The use of simultaneous reprogramming and gene correction to generate an osteogenesis imperfecta patient COL1A1 c. 3936 G > T iPSC line and an isogenic control iPSC line
Sara Howden, Hani Hosseini Far, Ali Motazedian, Andrew G Elefanty, Edouard G Stanley, Shireen R Lamande, John F Bateman
Journal article | 2019 | Stem Cell Research
To develop a disease model for the human 'brittle bone' disease, osteogenesis imperfecta, we used a simultaneous reprogramming and..
Extra-skeletal manifestations in mice affected by Clcn7-dependent autosomal dominant osteopetrosis type 2 clinical and therapeutic implications
Antonio Maurizi, Mattia Capulli, Annabel Curle, Rajvi Patel, Argia Ucci, Juliana Alves Cortes, Harriet Oxford, Shireen R Lamande, John F Bateman, Nadia Rucci, Anna Teti
Journal article | 2019 | Bone Research
Generation of a heterozygous COL1A1 (c.3969_3970insT) osteogenesis imperfecta mutation human iPSC line, MCRIi001-A-1, using CRISPR/Cas9 editing
Hani Hosseini Far, Yudha Nur Patria, Ali Motazedian, Andrew G Elefanty, Edouard G Stanley, Shireen R Lamande, John F Bateman
Journal article | 2019 | Stem Cell Research
Effect of rapamycin on bone mass and strength in the alpha 2(I)-G610C mouse model of osteogenesis imperfecta
John F Bateman, Lisa Sampurno, Antonio Maurizi, Shireen R Lamande, Natalie A Sims, Tegan L Cheng, Aaron Schindeler, David G Little
Journal article | 2019 | Journal of Cellular and Molecular Medicine
Identification of TGFβ-related genes regulated in murine osteoarthritis and chondrocyte hypertrophy by comparison of multiple microarray datasets.
Laurie MG de Kroon, Guus GH van den Akker, Bent Brachvogel, Roberto Narcisi, Daniele Belluoccio, Florien Jenner, John F Bateman, Christopher B Little, Pieter AJ Brama, Esmeralda N Blaney Davidson, Peter M van der Kraan, Gerjo JVM van Osch
Journal article | 2018 | Bone
OBJECTIVE: Osteoarthritis (OA) is a joint disease characterized by progressive degeneration of articular cartilage. Some features ..
Cartilage MicroRNA Dysregulation During the Onset and Progression of Mouse Osteoarthritis Is Independent of Aggrecanolysis and Overlaps With Candidates From End-Stage Human Disease
Louise HW Kung, Varshini Ravi, Lynn Rowley, Constanza Angelucci, Amanda J Fosang, Katrina M Bell, Christopher B Little, John F Bateman
Journal article | 2018 | ARTHRITIS & RHEUMATOLOGY
Increased intracellular proteolysis reduces disease severity in an ER stress-associated dwarfism.
Lorna A Mullan, Ewa J Mularczyk, Louise H Kung, Mitra Forouhan, Jordan Ma Wragg, Royston Goodacre, John F Bateman, Eileithyia Swanton, Michael D Briggs, Raymond P Boot-Handford
Journal article | 2017 | J Clin Invest
The short-limbed dwarfism metaphyseal chondrodysplasia type Schmid (MCDS) is linked to mutations in type X collagen, which increas..
The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration
Michal Dudek, Nan Yang, Jayalath Pd Ruckshanthi, Jack Williams, Elzbieta Borysiewicz, Ping Wang, Antony Adamson, Jian Li, John F Bateman, Michael R White, Raymond P Boot-Handford, Judith A Hoyland, Qing-Jun Meng
Journal article | 2017 | Annals of the Rheumatic Diseases
Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NF kappa B-dependent pathway
B Guo, N Yang, E Borysiewicz, M Dudek, JL Williams, J Li, ES Maywood, A Adamson, MH Hastings, JF Bateman, MRH White, RP Boot-Handford, QJ Meng
Journal article | 2015 | Osteoarthritis and Cartilage
XBP1-Independent UPR Pathways Suppress C/EBP-beta Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease
Trevor L Cameron, Katrina M Bell, Irma L Gresshoff, Lisa Sampurno, Lorna Mullan, Joerg Ermann, Laurie H Glimcher, Raymond P Boot-Handford, John F Bateman
Journal article | 2015 | PLOS Genetics
Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization
TL Cameron, IL Gresshoff, KM Bell, KA Pirog, L Sampurno, CL Hartley, EM Sanford, R Wilson, J Ermann, RP Boot-Handford, LH Glimcher, MD Briggs, JF Bateman
Journal article | 2015 | Osteoarthritis and Cartilage
A mouse splice-site mutant and individuals with atypical chromosome 22q11.2 deletions demonstrate the crucial role for crkl in craniofacial and pharyngeal development.
Kerry A Miller, Tiong Y Tan, Megan F Welfare, Susan M White, Zornitza Stark, Ravi Savarirayan, Trent Burgess, Andrew A Heggie, Georgina Caruana, John F Bertram, John F Bateman, Peter G Farlie
Journal article | 2014 | Molecular Syndromology
The 22q11.2 deletion syndrome (22q11DS) is thought to be a contiguous gene syndrome caused by haploinsufficiency for a variable nu..
The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis
Nicole Gossan, Leo Zeef, James Hensman, Alun Hughes, John F Bateman, Lynn Rowley, Christopher B Little, Hugh D Piggins, Magnus Rattray, Raymond P Boot-Handford, Qing-Jun Meng
Journal article | 2013 | Arthritis & Rheumatism
Cauli: A Mouse Strain with an Ift140 Mutation That Results in a Skeletal Ciliopathy Modelling Jeune Syndrome
Kerry A Miller, Casey J Ah-Cann, Megan F Welfare, Tiong Y Tan, Kate Pope, Georgina Caruana, Mary-Louise Freckmann, Ravi Savarirayan, John F Bertram, Michael S Dobbie, John F Bateman, Peter G Farlie
Journal article | 2013 | PLoS Genetics
Transcriptomics of Wild-Type Mice and Mice Lacking ADAMTS-5 Activity Identifies Genes Involved in Osteoarthritis Initiation and Cartilage Destruction
John F Bateman, Lynn Rowley, Daniele Belluoccio, Ben Chan, Katrina Bell, Amanda J Fosang, Christopher B Little
Journal article | 2013 | ARTHRITIS AND RHEUMATISM
Comparative Proteomic Analysis of Normal and Collagen IX Null Mouse Cartilage Reveals Altered Extracellular Matrix Composition and Novel Components of the Collagen IX Interactome
Bent Brachvogel, Frank Zaucke, Keyur Dave, Emma L Norris, Jacek Stermann, Muenire Dayakli, Manuel Koch, Jeffrey J Gorman, John F Bateman, Richard Wilson
Journal article | 2013 | Journal of Biological Chemistry
Depletion of Annexin A5, Annexin A6, and Collagen X Causes No Gross Changes in Matrix Vesicle-Mediated Mineralization, but Lack of Collagen X Affects Hematopoiesis and the Th1/Th2 Response
Ivan Grskovic, Anna Kutsch, Christian Frie, Gergely Groma, Jacek Stermann, Ursula Schloetzer-Schrehardt, Anja Niehoff, Stephen E Moss, Sabrina Rosenbaum, Ernst Poeschl, Markus Chmielewski, Gunter Rappl, Hinrich Abken, John F Bateman, Kathryn SE Cheah, Mats Paulsson, Bent Brachvogel
Journal article | 2012 | Journal of Bone and Mineral Research
H-1 NMR Spectroscopy of Serum Reveals Unique Metabolic Fingerprints Associated with Subtypes of Surgically Induced Osteoarthritis in Sheep
Anthony D Maher, Chantal Coles, Jason White, John F Bateman, Emily S Fuller, Dan Burkhardt, Christopher B Little, Martin Cake, Richard Read, Matthew B McDonagh, Simone Jane Rochfort
Journal article | 2012 | Journal of Proteome Research
Recurrent Dominant Mutations Affecting Two Adjacent Residues in the Motor Domain of the Monomeric Kinesin KIF22 Result in Skeletal Dysplasia and Joint Laxity (vol 89, pg 769, 2011)
Eric D Boyden, A Belinda Campos-Xavier, Sebastian Kalamajski, Trevor L Cameron, Philippe Suarez, Goranka Tanackovic, Generoso Andria, Diana Ballhausen, Michael D Briggs, Claire Hartley, Daniel H Cohn, H Rosemarie Davidson, Christine Hall, Shiro Ikegawa, Pierre-Simon Jouk, Rainer Koenig, Andre Megarbane, Gen Nishimura, Ralph S Lachman, Geert Mortier, et al.
Journal article | 2012 | The American Journal of Human Genetics
Changes in the Chondrocyte and Extracellular Matrix Proteome during Post-natal Mouse Cartilage Development
Richard Wilson, Emma L Norris, Bent Brachvogel, Constanza Angelucci, Snezana Zivkovic, Lavinia Gordon, Bianca C Bernardo, Jacek Stermann, Kiyotoshi Sekiguchi, Jeffrey J Gorman, John F Bateman
Journal article | 2012 | Molecular and Cellular Proteomics
Recurrent Dominant Mutations Affecting Two Adjacent Residues in the Motor Domain of the Monomeric Kinesin KIF22 Result in Skeletal Dysplasia and Joint Laxity
Eric D Boyden, A Belinda Campos-Xavier, Sebastian Kalamajski, Trevor L Cameron, Philippe Suarez, Goranka Tanackovich, Generoso Andria, Diana Ballhausen, Michael D Briggs, Claire Hartley, Daniel H Cohn, H Rosemarie Davidson, Christine Hal, Shiro Ikegawa, Pierre-Simon Jouk, Rainer Koenig, Andre Megarbane, Gen Nishimura, Ralph S Lachman, Geert Mortier, et al.
Journal article | 2011 | American Journal of Human Genetics
Mutations in TRPV4 cause an inherited arthropathy of hands and feet
Shireen R Lamande, Yuan Yuan, Irma L Gresshoff, Lynn Rowley, Daniele Belluoccio, Kumara Kaluarachchi, Christopher B Little, Elke Botzenhart, Klaus Zerres, David J Amor, William G Cole, Ravi Savarirayan, Peter McIntyre, John F Bateman
Journal article | 2011 | Nature Genetics
Cartilage Intermediate Layer Protein 2 (CILP-2) Is Expressed in Articular and Meniscal Cartilage and Down-regulated in Experimental Osteoarthritis
Bianca C Bernardo, Daniele Belluoccio, Lynn Rowley, Christopher B Little, Uwe Hansen, John F Bateman
Journal article | 2011 | Journal of Biological Chemistry
Transcriptional Profiling of Chondrodysplasia Growth Plate Cartilage Reveals Adaptive ER-Stress Networks That Allow Survival but Disrupt Hypertrophy
Trevor L Cameron, Katrina M Bell, Liliana Tatarczuch, Eleanor J Mackie, M Helen Rajpar, Ben T McDermott, Raymond P Boot-Handford, John F Bateman
Journal article | 2011 | PLoS One
Collagen VI Microfibril Formation Is Abolished by an alpha 2(VI) von Willebrand Factor Type A Domain Mutation in a Patient with Ullrich Congenital Muscular Dystrophy
Leona D Tooley, Laura K Zamurs, Nicola Beecher, Naomi L Baker, Rachel A Peat, Naomi E Adams, John F Bateman, Kathryn N North, Clair Baldock, Shireen R Lamande
Journal article | 2010 | Journal of Biological Chemistry
Sorting of Growth Plate Chondrocytes Allows the Isolation and Characterization of Cells of a Defined Differentiation Status
Daniele Belluoccio, Julia Etich, Sabrina Rosenbaum, Christian Frie, Ivan Grskovic, Jacek Stermann, Harald Ehlen, Simon Vogel, Frank Zaucke, Klaus von der Mark, John F Bateman, Bent Brachvogel
Journal article | 2010 | Journal of Bone and Mineral Research
Deficiency of Annexins A5 and A6 Induces Complex Changes in the Transcriptome of Growth Plate Cartilage but Does Not Inhibit the Induction of Mineralization
Daniele Belluoccio, Ivan Grskovic, Anja Niehoff, Ursula Schloetzer-Schrehardt, Sabrina Rosenbaum, Julia Etich, Christian Frie, Friedericke Pausch, Stephen E Moss, Ernst Poeschl, John F Bateman, Bent Brachvogel
Journal article | 2010 | Journal of Bone and Mineral Research
Targeted Induction of Endoplasmic Reticulum Stress Induces Cartilage Pathology
M Helen Rajpar, Ben McDermott, Louise Kung, Rachel Eardley, Lynette Knowles, Mel Heeran, David J Thornton, Richard Wilson, John F Bateman, Richard Poulsom, Peter Arvan, Karl E Kadler, Michael D Briggs, Raymond P Boot-Handford
Journal article | 2009 | PLoS Genetics
Mutations in the Heparan-Sulfate Proteoglycan Glypican 6 (GPC6) Impair Endochondral Ossification and Cause Recessive Omodysplasia
Ana Belinda Campos-Xavier, Danielle Martinet, John Bateman, Dan Belluoccio, Lynn Rowley, Tiong Yang Tan, Alica Baxova, Karl-Henrik Gustavson, Zvi U Borochowitz, A Micheil Innes, Sheila Unger, Jacques S Beckmann, Laureane Mittaz, Diana Ballhausen, Andrea Superti-Furga, Ravi Savarirayan, Luisa Bonafe
Journal article | 2009 | American Journal of Human Genetics
Autophagic Elimination of Misfolded Procollagen Aggregates in the Endoplasmic Reticulum as a Means of Cell Protection
Yoshihito Ishida, Akitsugu Yamamoto, Akira Kitamura, Shireen R Lamande, Tamotsu Yoshimori, John F Bateman, Hiroshi Kubota, Kazuhiro Nagata
Journal article | 2009 | Molecular Biology of the Cell
Mice Lacking the Extracellular Matrix Protein WARP Develop Normally but Have Compromised Peripheral Nerve Structure and Function
Justin M Allen, Laura Zamurs, Bent Brachvogel, Ursula Schloetzer-Schrehardt, Uwe Hansen, Shireen R Lamande, Lynn Rowley, Jamie Fitzgerald, John F Bateman
Journal article | 2009 | Journal of Biological Chemistry
Collagen VI glycine mutations: Perturbed assembly and a spectrum of clinical severity
Rishika A Pace, Rachel A Peat, Naomi L Baker, Laura Zamurs, Matthias Moergelin, Melita Irving, Naomi E Adams, John F Bateman, David Mowat, Nicholas JC Smith, Phillipa J Lamont, Steven A Moore, Katherine D Mathews, Kathryn N North, Shireen R Lamande
Journal article | 2008 | Annals of Neurology
Competency for nonsense-mediated reduction in collagen X mRNA is specified by the 3 ' UTR and corresponds to the position of mutations in schmid metaphyseal chondrodysplasia
Jacqueline T Tan, Friederike Kremer, Susanna Freddi, Katrina M Bell, Shireen R Lamande, John E Bateman
Journal article | 2008 | American Journal of Human Genetics
Molecular consequences of dominant Bethlem myopathy collagen VI mutations
Naomi L Baker, Matthias Morgelin, Rishika A Pace, Rachel A Peat, Naomi E Adams, RJ McKinlay Gardner, Lewis P Rowland, Geoffrey Miller, Peter De Jonghe, Berten Ceulemans, Mark C Hannibal, Matthew Edwards, Elizabeth M Thompson, Richard Jacobson, Ros CM Quinlivan, Salim Aftimos, Andrew J Kornberg, Kathryn N North, John F Bateman, Shireen R Lamande
Journal article | 2007 | Annals of Neurology
Isolated Anxa5( )/Sca-1( ) perivascular cells from mouse meningeal vasculature retain their perivascular phenotype in vitro and in vivo
Bent Brachvogel, Friederike Pausch, Peter Farlie, Udo Gaipl, Julia Etich, Zhigang Zhou, Trevor Camerone, Klaus von der Mark, John F Bateman, Ernst Poeschl
Journal article | 2007 | Experimental Cell Research
Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function
Kwok Yeung Tsang, Danny Chan, Deborah Cheslett, Wilson CW Chan, Chi Leong So, Ian G Melhado, Tori WY Chan, Kin Ming Kwan, Ernst B Hunziker, Yoshihiko Yamada, John F Bateman, Kenneth MC Cheung, Kathryn SE Cheah
Journal article | 2007 | PLoS Biology
Misfolding of collagen X chains harboring Schmid metaphyseal chondrodysplasia mutations results in aberrant disulfide bond formation, intracellular retention, and activation of the unfolded protein response
R Wilson, S Freddi, D Chan, KSE Cheah, JF Bateman
Journal article | 2005 | Journal of Biological Chemistry
Identification of Four Novel COL10A1 Missense Mutations in Schmid Metaphyseal Chondrodysplasia: Further Evidence That Collagen X NC1 Mutations Impair Trimer Assembly
John F Bateman, Susanna Freddi, Robyn McNeil, Elizabeth Thompson, Pia Hermanns, Ravi Savarirayan, Shireen R Lamande
Journal article | 2004 | Human Mutation
MT1-MMP-dependent and -independent regulation of gelatinase a activation in long-term, ascorbate-treated fibroblast cultures: Regulation by fibrillar collagen
N Ruangpanit, JT Price, K Holmbeck, H Birkedal-Hansen, V Guenzler, XF Huang, D Chan, JF Bateman, EW Thompson
Journal article | 2002 | Experimental Cell Research
Reliable and sensitive detection of premature termination mutations using a protein truncation test designed to overcome problems of nonsense-mediated mRNA instability
JF Bateman, S Freddi, SR Lamande, P Byers, S Nasioulas, J Douglas, R Otway, M Kohonen-Corish, E Edkins, S Forrest
Journal article | 1999 | Human Mutation
Erratum: Reliable and sensitive detection of premature termination mutations using a protein truncation test designed to overcome problems of nonsense-mediated mRNA instability (Human Mutation (1999) 13 (311-317))
JF Bateman, S Freddi, SR Lamande, P Byers, S Nasioulas, J Douglas, R Otway, M Kohonen-Corish, E Edkins, S Forrest, E Solomon
Journal article | 1999 | Human Mutation
The role of the alpha 3(VI) chain in collagen VI assembly - Expression of an alpha 3(VI) chain lacking N-terminal modules N10-N7 restores collagen VI assembly, secretion, and matrix deposition in an alpha 3(VI)-deficient cell line
SR Lamande, E Sigalas, TC Pan, ML Chu, M Dziadek, R Timpl, JR Bateman
Journal article | 1998 | Journal of Biological Chemistry
The phenotypic features of osteogenesis imperfecta resulting from a mutation of the carboxyl-terminal pro alpha 1(I) propeptide that impairs the assembly of type I procollagen and formation of the extracellular matrix
WG Cole, CW Chow, JF Bateman, DO Sillence
Journal article | 1996 | Journal of Medical Genetics
Multiexon deletions in the type I collagen COL1A2 gene in osteogenesis imperfecta type IB - Molecules containing the shortened alpha 2(I) chains show differential incorporation into the bone and skin extracellular matrix
S Mundlos, D Chan, YM Weng, DO Sillence, WG Cole, JF Bateman
Journal article | 1996 | Journal of Biological Chemistry
An alpha 1(II) Gly(913) to Cys substitution prevents the matrix incorporation of type II collagen which is replaced with type I and III collagens in cartilage from a patient with hypochondrogenesis
S Mundlos, D Chan, J McGill, JF Bateman
Journal article | 1996 | American Journal of Medical Genetics - Seminars in Medical Genetics
ENDOPLASMIC RETICULUM-MEDIATED QUALITY-CONTROL OF TYPE-I COLLAGEN PRODUCTION BY CELLS FROM OSTEOGENESIS IMPERFECTA PATIENTS WITH MUTATIONS IN THE PRO-ALPHA-1(I) CHAIN CARBOXYL-TERMINAL PROPEPTIDE WHICH IMPAIR SUBUNIT ASSEMBLY
SR LAMANDE, SD CHESSLER, SB GOLUB, PH BYERS, D CHAN, WG COLE, DO SILLENCE, JF BATEMAN
Journal article | 1995 | Journal of Biological Chemistry
A 5' SPLICE-SITE MUTATION AFFECTING THE PRE-MESSENGER-RNA SPLICING OF 2 UPSTREAM EXONS IN THE COLLAGEN COL1A1 GENE - EXON-8 SKIPPING AND ALTERED DEFINITION OF EXON-7 GENERATES TRUNCATED PRO-ALPHA-1(I) CHAINS WITH A NONCOLLAGENOUS INSERTION DESTABILIZING THE TRIPLE-HELIX
JF BATEMAN, D CHAN, I MOELLER, M HANNAGAN, WG COLE
Journal article | 1994 | Biochemical Journal
Osteogenic capacity of collagen in repair of established periodontal defects.
G Ellender, R Hammond, R Papli, K Mitrangas, JF Bateman, V Glattauer, JM Thyer, JA Werkmeister, JA Ramshaw
Journal article | 1992 | Clinical Materials
Periodontal bone defects were established in four dogs, with one proximal lesion and one furcation lesion in each quadrant. These..
Lethal perinatal osteogenesis imperfecta due to a type I collagen alpha 2(I) Gly to Arg substitution detected by chemical cleavage of an mRNA:cDNA sequence mismatch.
JF Bateman, I Moeller, M Hannagan, D Chan, WG Cole
Journal article | 1992 | Human Mutation
A single base mismatch was detected by a chemical cleavage method in heteroduplexes formed between patient mRNA and a control coll..
A BASE SUBSTITUTION AT A SPLICE SITE IN THE COL3A1 GENE CAUSES EXON SKIPPING AND GENERATES ABNORMAL TYPE-III PROCOLLAGEN IN A PATIENT WITH EHLERS-DANLOS SYNDROME TYPE-IV
WG COLE, AA CHIODO, SR LAMANDE, R JANECZKO, F RAMIREZ, HHM DAHL, D CHAN, JF BATEMAN
Journal article | 1990 | Journal of Biological Chemistry
THE CLINICAL-FEATURES OF OSTEOGENESIS IMPERFECTA RESULTING FROM A NONFUNCTIONAL CARBOXY TERMINAL PRO-ALPHA-1(I) PROPEPTIDE OF TYPE-I PROCOLLAGEN AND A SEVERE DEFICIENCY OF NORMAL TYPE-I COLLAGEN IN TISSUES
WG COLE, PE CAMPBELL, JG ROGERS, JF BATEMAN
Journal article | 1990 | Journal of Medical Genetics
Correlation of clinical and molecular biological abnormalities in osteogenesis imperfecta.
W Cole, D Chan, S Lamande, T Mascara, J Rogers, J Bateman
Journal article | 1989 | Connective Tissue Research
Substitution of a glycine residue in the triple helix of the alpha 1(I) chain by either arginine, valine or alanine was associated..
SUBSTITUTION OF ARGININE FOR GLYCINE-664 IN THE COLLAGEN ALPHA-1(I) CHAIN IN LETHAL PERINATAL OSTEOGENESIS IMPERFECTA - DEMONSTRATION OF THE PEPTIDE DEFECT BY INVITRO EXPRESSION OF THE MUTANT CDNA
JF BATEMAN, SR LAMANDE, HHM DAHL, D CHAN, WG COLE
Journal article | 1988 | Journal of Biological Chemistry
INTRODUCTION OF THE HUMAN PRO-ALPHA1(I) COLLAGEN GENE INTO PRO-ALPHA1(I)-DEFICIENT MOV-13 MOUSE CELLS LEADS TO FORMATION OF FUNCTIONAL-MOUSE HUMAN HYBRID TYPE-I COLLAGEN
A SCHNIEKE, M DZIADEK, J BATEMAN, T MASCARA, K HARBERS, R GELINAS, R JAENISCH
Journal article | 1987 | Proceedings of the National Academy of Sciences
Inhibition by tumor-promoting phorbol esters of procollagen synthesis in promotable JB6 mouse epidermal cells.
LD Dion, J Bear, J Bateman, LM De Luca, NH Colburn
Journal article | 1982 | Journal of the National Cancer Institute
The JB6 mouse epidermal cell line has been developed to study promotion of neoplastic transformation in vitro. Treatment of JB6 ce..
Characterization of the collagen synthesized by cultured cartilage cells.
CJ Handley, JF Bateman, BW Oakes, DA Lowther
Journal article | 1975 | Biochimica et Biophysica Acta (BBA) - Protein Structure
Cartilage cells from embryonic chick cartilage were grown in primary cultures. The cell layer was sequentially extracted with neut..
Biochemistry And Molecular Biology
Paediatrics Royal Children'S Hospital
Doctor of Philosophy
Bachelor of Science