Andrew Wise

Biological Considerations of Optical Interfaces for Neuromodulation

William L Hart, Tatiana Kameneva, Andrew K Wise, Paul R Stoddart

Journal article  |  2019  |  Advanced Optical Materials

The success of devices such as cochlear implants and pacemakers has led to increasing interest in new applications of artificial n..

Engineering Biocoatings To Prolong Drug Release from Supraparticles

Yutian Ma, Christina Cortez-Jugo, Jianhua Li, Zhixing Lin, Rachael T Richardson, Yiyuan Han, Jiajing Zhou, Mattias Bjornmalm, Orlagh M Feeney, Qi-Zhi Zhong, Christopher JH Porter, Andrew K Wise, Frank Caruso

Journal article  |  2019  |  Biomacromolecules

Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of intere..

Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes

Jeremy L Pinyon, Georg von Jonquieres, Edward N Crawford, Mayryl Duxbury, Amr Al Abed, Nigel H Lovell, Matthias Klugmann, Andrew K Wise, James B Fallon, Robert K Shepherd, Catherine S Birman, Waikong Lai, David McAlpine, Catherine McMahon, Paul M Carter, Ya Lang Enke, James F Patrick, Anne GM Schilder, Corinne Marie, Daniel Scherman, et al.

Journal article  |  2019  |  Hearing Research

This Review outlines the development of DNA-based therapeutics for treatment of hearing loss, and in particular, considers the pot..

New molecular therapies for the treatment of hearing loss.

Yutian Ma, Andrew K Wise, Robert K Shepherd, Rachael T Richardson

Journal article  |  2019  |  Pharmacology & Therapeutics

An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing loss is characterized by degeneration of..

Pharmacokinetics and tissue distribution of neurotrophin 3 after intracochlear delivery

Rachael T Richardson, Qi-Ying Hu, Fuxin Shi, Nguyen Trung, James B Fallon, Brianna O Flynn, Andrew K Wise

Journal article  |  2019  |  Journal of Controlled Release

Chronic intracochlear electrical stimulation at high charge densities results in platinum dissolution but not neural loss or functional changes in vivo

Robert K Shepherd, Paul M Carter, Ya Lang Enke, Andrew K Wise, James B Fallon

Journal article  |  2019  |  Journal of Neural Engineering

Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery

Yutian Ma, Mattias Bjoernmalm, Andrew K Wise, Christina Cortez-Jugo, Eve Revalor, Yi Ju, Orlagh M Feeney, Rachael T Richardson, Eric Hanssen, Robert K Shepherd, Christopher JH Porter, Frank Caruso

Journal article  |  2018  |  ACS Applied Materials & Interfaces

Comparing perilymph proteomes across species.

Jonathan C Palmer, Megan S Lord, Jeremy L Pinyon, Andrew K Wise, Nigel H Lovell, Paul M Carter, Ya Lang Enke, Gary D Housley, Rylie A Green

Journal article  |  2018  |  The Laryngoscope

OBJECTIVES/HYPOTHESIS: Biological components of perilymph affect the electrical performance of cochlear implants. Understanding th..

Structural and Ultrastructural Changes to Type I Spiral Ganglion Neurons and Schwann Cells in the Deafened Guinea Pig Cochlea

Andrew K Wise, Remy Pujol, Thomas G Landry, James B Fallon, Robert K Shepherd

Journal article  |  2017  |  Journal of the Association for Research in Otolaryngology

Heterogeneity of Purkinje cell simple spike-complex spike interactions: zebrin- and non-zebrin-related variations

Tianyu Tang, Jianqiang Xiao, Colleen Y Suh, Amelia Burroughs, Nadia L Cerminara, Linjia Jia, Sarah P Marshall, Andrew K Wise, Richard Apps, Izumi Sugihara, Eric J Lang

Journal article  |  2017  |  The Journal of Physiology

Evaluation of focused multipolar stimulation for cochlear implants: a preclinical safety study

Robert K Shepherd, Andrew K Wise, Ya Lang Enke, Paul M Carter, James B Fallon

Journal article  |  2017  |  Journal of Neural Engineering

The auditory system

BA Nayagam, AK Wise, RK Shepherd

Book Chapter  |  2017

Challenges for the application of optical stimulation in the cochlea for the study and treatment of hearing loss

Rachael T Richardson, Alexander C Thompson, Andrew K Wise, Karina Needham

Journal article  |  2017  |  Expert Opinion on Biological Therapy

The dynamic relationship between cerebellar Purkinje cell simple spikes and the spikelet number of complex spikes

Amelia Burroughs, Andrew K Wise, Jianqiang Xiao, Conor Houghton, Tianyu Tang, Colleen Y Suh, Eric J Lang, Richard Apps, Nadia L Cerminara

Journal article  |  2017  |  The Journal of Physiology

Improved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened Cochlea

Andrew K Wise, Justin Tan, Yajun Wang, Frank Caruso, Robert K Shepherd

Journal article  |  2016  |  PLOS ONE

Understanding the cochlear implant environment by mapping perilymph proteomes from different species.

Jonathan C Palmer, Megan S Lord, Jeremy L Pinyon, Andrew K Wise, Nigel H Lovell, Paul M Carter, Ya Lang Enke, Gary D Housley, Rylie A Green

Conference Proceedings  |  2016  |  2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Cochlear implants operate within a bony channel of the cochlea, bathed in a fluid known as the perilymph. The perilymph is a compl..

Second spatial derivative analysis of cortical surface potentials recorded in cat primary auditory cortex using thin film surface arrays: Comparisons with multi-unit data

James B Fallon, Sam Irving, Satinderpall S Pannu, Angela C Tooker, Andrew K Wise, Robert K Shepherd, Dexter RF Irvine

Journal article  |  2016  |  Journal of Neuroscience Methods

Electrophysiological channel interactions using focused multipolar stimulation for cochlear implants

Shefin S George, Mohit N Shivdasani, Andrew K Wise, Robert K Shepherd, James B Fallon

Journal article  |  2015  |  Journal of Neural Engineering

Infrared neural stimulation fails to evoke neural activity in the deaf guinea pig cochlea

Alexander C Thompson, James B Fallon, Andrew K Wise, Scott A Wade, Robert K Shepherd, Paul R Stoddart

Journal article  |  2015  |  Hearing Research

Evaluation of focused multipolar stimulation for cochlear implants in long-term deafened cats

Shefin S George, Andrew K Wise, James B Fallon, Robert K Shepherd

Journal article  |  2015  |  Journal of Neural Engineering

Cell and gene therapies for the treatment of hearing disorders

LN Gillespie, RT Richardson, AK Wise, BA Nayagam

Book Chapter  |  2015

Ultrastructural Changes in Type I Spiral Ganglion Neurons and their Glial Cells in the Deafened Guinea Pig Cochlea

AK Wise, R Pujol, TG Landry, JB Fallon, RK Shepherd

Conference Proceedings  |  2015

Treating hearing disorders with cell and gene therapy

Lisa N Gillespie, Rachael T Richardson, Bryony A Nayagam, Andrew K Wise

Journal article  |  2014  |  Journal of Neural Engineering

Evaluation of focused multipolar stimulation for cochlear implants in acutely deafened cats

Shefin S George, Andrew K Wise, Mohit N Shivdasani, Robert K Shepherd, James B Fallon

Journal article  |  2014  |  Journal of Neural Engineering

Drug delivery: mesoporous silica supraparticles for sustained inner-ear drug delivery (small 21/2014).

Y Wang, AK Wise, J Tan, JW Maina, RK Shepherd, F Caruso

Journal article  |  2014  |  Small

Mesoporous silica supraparticles (MS-SPs) self-assembled from mesoporous silica nanoparticles are reported on page 4244 by F. Caru..

Mold-Templated Inorganic-Organic Hybrid Supraparticles for Code livery of Drugs

James W Maina, Jiwei Cui, Mattias Bjoernmalm, Andrew K Wise, Robert K Shepherd, Frank Caruso

Journal article  |  2014  |  Biomacromolecules

Effects of deafness and cochlear implant use on temporal response characteristics in cat primary auditory cortex

James B Fallon, Robert K Shepherd, David AX Nayagam, Andrew K Wise, Leon F Heifer, Thomas G Landry, Dexter RF Irvine

Journal article  |  2014  |  Hearing Research

Systematic Regional Variations in Purkinje Cell Spiking Patterns

Jianqiang Xiao, Nadia L Cerminara, Yuriy Kotsurovskyy, Hanako Aoki, Amelia Burroughs, Andrew K Wise, Yuanjun Luo, Sarah P Marshall, Izumi Sugihara, Richard Apps, Eric J Lang

Journal article  |  2014  |  PLoS One

A partial hearing animal model for chronic electro-acoustic stimulation

S Irving, AK Wise, RE Millard, RK Shepherd, JB Fallon

Journal article  |  2014  |  Journal of Neural Engineering

Hair Cell Regeneration after ATOH1 Gene Therapy in the Cochlea of Profoundly Deaf Adult Guinea Pigs

Patrick J Atkinson, Andrew K Wise, Brianna O Flynn, Bryony A Nayagam, Rachael T Richardson

Journal article  |  2014  |  PLoS One

Chronic Electrical Stimulation with a Suprachoroidal Retinal Prosthesis: A Preclinical Safety and Efficacy Study

David AX Nayagam, Richard A Williams, Penelope J Allen, Mohit N Shivdasani, Chi D Luu, Cesar M Salinas-LaRosa, Sue Finch, Lauren N Ayton, Alexia L Saunders, Michelle McPhedran, Ceara McGowan, Joel Villalobos, James B Fallon, Andrew K Wise, Jonathan Yeoh, Jin Xu, Helen Feng, Rodney Millard, Melanie McWade, Patrick C Thien, et al.

Journal article  |  2014  |  PLoS One

Gene Therapy Boosts the Bionic Ear

Robert K Shepherd, Andrew K Wise

Journal article  |  2014  |  Science Translational Medicine

Viability of Long-Term Gene Therapy in the Cochlea

Patrick J Atkinson, Andrew K Wise, Brianna O Flynn, Bryony A Nayagam, Rachael T Richardson

Journal article  |  2014  |  Scientific Reports

Measurement of Forces at the Tip of a Cochlear Implant During Insertion

Scott A Wade, James B Fallon, Andrew K Wise, Robert K Shepherd, Natalie L James, Paul R Stoddart

Journal article  |  2014  |  IEEE Transactions on Biomedical Engineering

The Association of HMGB1 Gene with the Prognosis of HCC

Jianbiao Xiao, Yi Ding, Jing Huang, Qisheng Li, Ying Liu, Wen Ni, Yuqin Zhang, Yanfei Zhu, Longhua Chen, Bin Chen

Journal article  |  2014  |  PLoS ONE

Mesoporous Silica Supraparticles for Sustained Inner-Ear Drug Delivery

Y Wang, JW Maina, F Caruso, AK Wise, RK Shepherd, J Tan

Journal article  |  2014  |  Small

Electroacoustic Stimulation: Now and into the Future

S Irving, L Gillespie, R Richardson, D Rowe, JB Fallon, AK Wise

Journal article  |  2014  |  BioMed Research International

Neurotrophin delivery using nanoengineered mesoporous silica particles for spiral ganglion neuron survival in the deaf cochlea

AK Wise, J Tan, Y Wang, F Caruso, RK Shepherd

Conference Proceedings  |  2014

Cochlear implantation for chronic electrical stimulation in the mouse

S Irving, MI Trotter, JB Fallon, RE Millard, RK Shepherd, AK Wise

Journal article  |  2013  |  Hearing Research

Impact of Morphometry, Myelinization and Synaptic Current Strength on Spike Conduction in Human and Cat Spiral Ganglion Neurons

Frank Rattay, Thomas Potrusil, Cornelia Wenger, Andrew K Wise, Rudolf Glueckert, Anneliese Schrott-Fischer

Journal article  |  2013  |  PLoS ONE

Cochlear implants

R Shepherd, A Wise, J Fallon

Scholarly edition  |  2013  |  Handbook of Clinical Neurophysiology

Gene Therapy after Hearing Loss

PJ Atkinson, AK Wise, BO Flynn, BA Nayagam, CR Hume, SJ O’Leary, RK Shepherd, RT Richardson

Conference Proceedings  |  2013

Purpose: The most common cause of deafness is due to the loss of cochlear hair cells and a degeneration of the sensory epithelia. ..

Effects of chronic electro-acoustic stimulation on auditory cortical responses

JB Fallon, S Irving, AK Wise, RK Shepherd, H McDermott, DRF Irvine

Conference Proceedings  |  2013

Evaluation of Phased Array Current-Focussing Strategy in Cochlear Implants using Animal Models

S George, JB Fallon, AK Wise, MN Shivdasani, RK Shepherd

Conference Proceedings  |  2013

Purpose: Cochlear implants restore high levels of speech perception in people with profound deafness by electrically stimulating t..

Ultrastructural changes in the deafened guinea pig cochlea following treatment with neurotrophins and electrical stimulation

AK Wise, R Pujol, JB Fallon, TG Landry, RK Shepherd

Conference Proceedings  |  2013

Purpose: Spiral ganglion neurons (SGNs) in the deafened cochlea undergo continual degeneration ultimately leading to cell death. T..

Chronic neurotrophin delivery promotes ectopic neurite growth from the spiral ganglion of deafened cochleae without compromising the spatial selectivity of cochlear implants

TG Landry, JB Fallon, AK Wise, RK Shepherd

Journal article  |  2013  |  Journal of Comparative Neurology

Evaluation of Phased Array Current-Focussing Strategy in Cochlear Implants using Animal Models

S George, JB Fallon, AK Wise, RK Shepherd

Conference Proceedings  |  2013

Drug delivery to the cochlea for neural survival

AK Wise

Conference Proceedings  |  2013

Auditory neurons, the target cells of the cochlear implant, undergo progressive degeneration following deafness, ultimately leadin..

Drug delivery to the cochlea for neural survival

AK Wise

Conference Proceedings  |  2013

Auditory neurons, the target cells of the cochlear implant, undergo progressive degeneration following deafness, ultimately leadin..

Regeneration of the Cochlea After Deafness

PJ Atkinson, AK Wise, BO Flynn, B Nayagam, CR Hume, SJ O’Leary, RK Shepherd, RT Richardson

Conference Proceedings  |  2013

Purpose: The most common cause of deafness is due to the loss of cochlear hair cells and a degeneration of the sensory epithelia. ..

Histological Methods for Evaluating the Safety of Retinal Prostheses

C McGowan, R Williams, I Durmo, C Salinas-La Rosa, P McKelvie, M Basa, I Lo, J Tan, AK Wise, C Williams, RK Shepherd, DAX Nayagam

Conference Proceedings  |  2013

Cochlear Implants

RK Shepherd, A Wise, JB Fallon

Book Chapter  |  2013

Evaluation of Phased Array Current-Focussing Strategy in Cochlear Implants using Animal Models

S George, JB Fallon, AK Wise, RK Shepherd

Conference Proceedings  |  2013

Evaluation of Phased Array Current-Focussing Strategy in Cochlear Implants using Animal Models

S George, JB Fallon, AK Wise, RK Shepherd

Conference Proceedings  |  2013

Effects of Age on the Preservation of Residual Hearing with Cochlear Implants

AK Wise, S Irving, RK Shepherd, JB Fallon

Conference Proceedings  |  2013

Background Cochlear implant (CI) recipients with residual hearing in their implanted ear receive both electric and acoustic stimul..

The Effects of Neurotrophins and Chronic Electrical Stimulation

AK Wise, R Pujol, TG Landry, JB Fallon, RK Shepherd

Conference Proceedings  |  2013

Background Spiral ganglion neurons (SGNs) in the deafened cochlea undergo continual degeneration ultimately resulting in cell deat..

Neurotrophin Gene Therapy for Sustained Neural Preservation after Deafness

Patrick J Atkinson, Andrew K Wise, Brianna O Flynn, Bryony A Nayagam, Clifford R Hume, Stephen J O'Leary, Robert K Shepherd, Rachael T Richardson

Journal article  |  2012  |  PLoS One

Drug delivery to the inner ear

Andrew K Wise, Lisa N Gillespie

Journal article  |  2012  |  Journal of Neural Engineering

Anti-apoptotic gene Bcl2 is required for stapes development and hearing

MR Carpinelli, AK Wise, BD Arhatari, P Bouillet, SSM Manji, MG Manning, AA Cooray, RA Burt

Journal article  |  2012  |  Cell Death & Disease

Residual hearing loss in Hybrid cochlear implant users: a strategic approach to investigation

K Verhoeven, AK Wise, L Nolan, R Taylor, JB Fallon, A Forge, RK Shepherd, J Patrick

Conference Proceedings  |  2012

Gene Therapy After Hearing Loss for Long-Term Neural Protection

PJ Atkinson, AK Wise, BO Flynn, B Nayagam, CR Hume, RK Shepherd, SJ O’Leary, RT Richardson

Conference Proceedings  |  2012

Investigation of potential determinants of the complex spike waveform: zebrin reactivity and simple spike activity.

J Xiao, NL Cerminara, H Aoki, I Sugihara, AK Wise, J Sanderson, P Fryzlewicz, R Apps, EL Lang

Conference Proceedings  |  2012

Zebrin staining subdivides the cerebellar cortex into longitudinal zones that align with the topography of both the olivocerebella..

The effects of neurotrophins and chronic electrical stimulation delivered to the deafened guinea pig cochlea

AK Wise, R Pujol, JB Fallon, TG Landry, RK Shepherd

Conference Proceedings  |  2012

Purpose: Spiral ganglion neurons (SGNs) in the deafened cochlea undergo continual degeneration ultimately resulting in cell death...

Clinically relevant drug delivery to the cochlea

AK Wise

Conference Proceedings  |  2012

Auditory neurons, the target cells of the cochlear implant, undergo progressive degeneration following deafness, ultimately leadin..

Gene Therapy After Hearing Loss for Long-Term Neural Protection

PJ Atkinson, AK Wise, BO Flynn, BA Nayagam, CR Hume, SJ O’Leary, RK Shepherd, RT Richardson

Conference Proceedings  |  2012

Background: The administration of exogenous neurotrophins to the deafened cochlea via mini-osmotic pumps can promote spiral gangli..

Gene Therapy After Hearing Loss for Long-Term Neural Protection

PJ Atkinson, AK Wise, BO Flynn, BA Nayagam, CR Hume, SJ O’Leary, RK Shepherd, RT Richardson

Conference Proceedings  |  2012

The administration of exogenous neurotrophins (NTs) to the deafened cochlea via mini-osmotic pumps can promote spiral ganglion neu..

Combining cell-based therapies and cochlear implants to promote nerve survival

AK Wise, JB Fallon, AJ Neil, LN Pettingill, MC Geaney, RK Shepherd

Conference Proceedings  |  2012

Spiral ganglion neurons (SGNs) in the deafened cochlea undergo continual degeneration ultimately resulting in cell death. The exog..

Survival of Spiral Ganglion Neurons in Mice after Chronic Intracochlear Stimulation

S Irving, AK Wise, R Millard, M Trotter, JB Fallon, RK Shepherd

Conference Proceedings  |  2012

Spiral ganglion neurons (SGNs) are well known to degenerate after the onset of hearing loss. There remains some debate in the lite..

Preservation of Residual Hearing in an Animal Model

AL Morley, JB Fallon, AK Wise, S Irving, A Neil, N Critch, RK Shepherd

Conference Proceedings  |  2012

Cochlear implant recipients with residual (acoustic) hearing in their implanted ear can receive both electrical and acoustic stimu..

Development of an improved cochlear electrode array for use in experimental studies

AK Wise, K Verhoeven, J Xu, F Risi, JB Fallon, RK Shepherd

Conference Proceedings  |  2012

Animal studies play an important role in establishing the safety and efficacy of cochlear implants and the development of new elec..

Gene Therapy After Hearing Loss for Long-Term Neural Protection

PJ Atkinson, AK Wise, BO Flynn, B Nayagam, CR Hume, RK Shepherd, SJ O’Leary, RT Richardson

Conference Proceedings  |  2012

A surgical technique for chronic active stimulation with a suprachoroidal electrode array in a feline model

PJ Allen, J Yeoh, MF McCombe, AK Wise, W Heriot, MN Shivdasani, CE Williams, DAX Nayagam, RK Shepherd, RH Guymer

Conference Proceedings  |  2012

Simple spike activity of cerebellar Purkinje cells associated with complex spike waveform variations.

NL Cerminara, J Sanderson, AK Wise, J Xiao, P Fryzlewicz, EL Lang, R Apps

Conference Proceedings  |  2012

Cerebellar Purkinje cells (PCs) produce two different types of action potentials: simple spikes (SSs) which can be generated intri..

An implantable chronic stimulator for use in mice

S Irving, AK Wise, R Millard, M Trotter, JB Fallon, RK Shepherd

Conference Proceedings  |  2012

Purpose Spiral ganglion neurons (SGNs) are well known to degenerate after the onset of hearing loss. There remains some debate in ..

Influenza Virus Induces Bacterial and Nonbacterial Otitis Media

Kirsty R Short, Dimitri A Diavatopoulos, Ruth Thornton, John Pedersen, Richard A Strugnell, Andrew K Wise, Patrick C Reading, Odilia L Wijburg

Journal article  |  2011  |  Journal of Infectious Diseases

Spiral ganglion neuron survival and function in the deafened cochlea following chronic neurotrophic treatment

Thomas G Landry, Andrew K Wise, James B Fallon, Robert K Shepherd

Journal article  |  2011  |  Hearing Research

Combining Cell-Based Therapies and Neural Prostheses to Promote Neural Survival

Andrew K Wise, James B Fallon, Alison J Neil, Lisa N Pettingill, Marilyn S Geaney, Stephen J Skinner, Robert K Shepherd

Journal article  |  2011  |  Neurotherapeutics

The effect of deafness duration on neurotrophin gene therapy for spiral ganglion neuron protection

Andrew K Wise, Tian Tu, Patrick J Atkinson, Brianna O Flynn, Beatrice E Sgro, Cliff Hume, Stephen J O'Leary, Robert K Shepherd, Rachael T Richardson

Journal article  |  2011  |  Hearing Research

An improved cochlear implant electrode array for use in experimental studies

Robert Shepherd, Kristien Verhoeven, Jin Xu, Frank Risi, James Fallon, Andrew Wise

Journal article  |  2011  |  Hearing Research

NEUROTROPHIN GENE THERAPY FOR AUDITORY NERVE SURVIVAL AND DIRECTED FIBRE REGROWTH AFTER HEARING LOSS

Rachael T Richardson, Patrick Atkinson, Tian Tu, Andrew Wise, Brianna Flynn, Cliff Hume, Stephen O'Leary, Rob Shepherd

Conference Proceedings  |  2011  |  JOURNAL OF GENE MEDICINE

Vitamin D-deficient diet rescues hearing loss in Klotho mice

Marina R Carpinelli, Andrew K Wise, Rachel A Burt

Journal article  |  2011  |  Hearing Research

Enhanced Auditory Neuron Survival Following Cell-Based BDNF Treatment in the Deaf Guinea Pig

Lisa N Pettingill, Andrew K Wise, Marilyn S Geaney, Robert K Shepherd

Journal article  |  2011  |  PLoS One

A pre-clinical model for chronic electrical stimulation of the retina via suprachoroidal electrodes

DAX Nayagam, PJ Allen, MN Shivdasani, JB Fallon, M Gault, J Yeoh, AK Wise, CD Luu, A Freemantle, M McPhedran, RA Williams, M Basa, L Ayton, E Bowman, RK Shepherd, CE Williams

Conference Proceedings  |  2011

An improved cochlear electrode array for use in experimental studies

AK Wise, K Verhoeven, J Xu, F Risi, JB Fallon, RK Shepherd

Conference Proceedings  |  2011

We evaluated the safety and efficacy of a new electrode array designed to more accurately simulate the electrode insertion depths ..

Combining cell-based therapies and neuroprostheses to promote nerve survival

AK Wise, JB Fallon, AJ Neil, LN Pettingill, M Geaney, RK Shepherd

Conference Proceedings  |  2011

Spiral ganglion neurons (SGNs) in the deafened cochlea undergo continual degeneration ultimately resulting in cell death. The exog..

Development of an improved cochlear electrode array for use in experimental studies

AK Wise, K Verhoeven, J Xu, F Risi, JB Fallon, RK Shepherd

Conference Proceedings  |  2011

Animal studies play an important role in establishing the safety and efficacy of cochlear implants and the development of new elec..

Combining cell-based therapies and neuroprostheses to promote nerve survival

AK Wise, JB Fallon, AJ Neil, LN Pettingill, M Geaney, RK Shepherd

Conference Proceedings  |  2011

Purpose: Spiral ganglion neurons (SGNs) in the deafened cochlea undergo continual degeneration ultimately resulting in cell death...

Drug delivery systems for inner ear protection and regeneration

AK Wise

Conference Proceedings  |  2011

Auditory neurons, the target cells of the cochlear implant, undergo progressive degeneration following deafness, ultimately leadin..

Development of an improved cochlear electrode array for use in experimental studies

AK Wise, K Verhoeven, J Xu, F Risi, JB Fallon, RK Shepherd

Conference Proceedings  |  2011

Animal studies play an important role in establishing the safety and efficacy of cochlear implants and the development of new elec..

Gene Therapy for the Preservation of Spiral Ganglion Neurons After Deafness

PJ Atkinson, AK Wise, T Tu, BO Flynn, B Nayagam, SJ O’Leary, RT Richardson

Conference Proceedings  |  2011

Physiological Insights Into The Problem Of Temporal Coding In Cochlear Implants

IC Bruce, AK Wise, MH Negm, JB Fallon, RK Shepherd

Conference Proceedings  |  2011

A long-standing view in cochlear implant (CI) research has been that auditory nerve (AN) fibers can encode the temporal properties..

Gene Therapy for the Preservation of Spiral Ganglion Neurons After Deafness

PJ Atkinson, AK Wise, T Tu, BO Flynn, B Nayagam, SJ O’Leary, RT Richardson

Conference Proceedings  |  2011

Neurotrophin Induced Ectopic Growth Of Peripheral Processes Does Not Compromise The Cochleotopic Organization Of The Implanted Cochlea

TG Landry, AK Wise, JB Fallon, RK Shepherd

Conference Proceedings  |  2011

Spiral ganglion neurons (SGNs), undergo progressive degeneration in deafness. In animal models, exogenous delivery of neurotrophic..

Reconnecting the cochlea after hearing loss

PJ Atkinson, AK Wise, T Tu, BO Flynn, B Nayagam, SJ O’Leary, RT Richardson

Conference Proceedings  |  2011

Development of an improved cochlear electrode array for use in experimental studies

AK Wise, K Verhoeven, J Xu, F Risi, JB Fallon, RK Shepherd

Conference Proceedings  |  2011

Purpose: Animal studies play an important role in establishing the safety and efficacy of cochlear implants and the development of..

An implantable chronic stimulator for use in mice.

S Irving, AK Wise, R Millard, M Trotter, JB Fallon, RK Shepherd

Conference Proceedings  |  2011

Introduction The use of mice in biomedical research has increased over the past decades due to the availability of a wide range of..

Reconnecting the cochlea after hearing loss

PJ Atkinson, AK Wise, T Tu, BO Flynn, B Nayagam, SJ O’Leary, RT Richardson

Conference Proceedings  |  2011

Gene Therapy for the Preservation of Spiral Ganglion Neurons After Deafness

PJ Atkinson, AK Wise, T Tu, BO Flynn, B Nayagam, SJ O’Leary, RT Richardson

Conference Proceedings  |  2011

Drug delivery to the inner ear

AK Wise, LN Pettingill

Conference Proceedings  |  2011

Introduction Auditory neurons, the target cells of the cochlear implant, undergo progressive degeneration following deafness, ulti..

A pre-clinical model for chronic electrical stimulation of the retina via suprachoroidal electrodes

DAX Nayagam, PJ Allen, MN Shivdasani, JB Fallon, M Gault, J Yeoh, AK Wise, CD Luu, A Freemantle, M McPhedran, RA Williams, M Basa, L Ayton, E Bowman, RK Shepherd, CE Williams

Conference Proceedings  |  2011

Reconnecting the cochlea after hearing loss

PJ Atkinson, AK Wise, T Tu, BO Flynn, B Nayagam, SJ O’Leary, RT Richardson

Conference Proceedings  |  2011

The effects of encapsulated BDNF-Schwann cells on auditory neuron survival In deafness

L Pettingill, AK Wise, MS Geaney, RK Shepherd

Conference Proceedings  |  2011

The Use Of A Cochlear Implant And Cell-Based Therapies To Promote Nerve Survival

AK Wise, JB Fallon, AJ Neil, L Pettingill, MS Geaney, RK Shepherd

Conference Proceedings  |  2011

Spiral ganglion neurons (SGNs) in the deafened cochlea undergo continual degeneration ultimately resulting in cell death. The exog..

Enhanced Auditory Neuron Survival Following Cell-Based BDNF Treatment In The Deaf Guinea Pig

L Pettingill, AK Wise, MS Geaney, RK Shepherd

Conference Proceedings  |  2011

Gene Therapy for the Prevention of Degeneration and Restoration of Cochlear Sensory Cells after Hearing Loss

RT Richardson, PJ Atkinson, AK Wise, BO Flynn, T Tu, BE Sgro, SJ O’Leary, CR Hume, RK Shepherd

Conference Proceedings  |  2011

A pre-clinical model for chronic electrical stimulation of the retina via suprachoroidal electrodes

DAX Nayagam, PJ Allen, MN Shivdasani, JB Fallon, M Gault, J Yeoh, AK Wise, CD Luu, A Freemantle, M McPhedran, RA Williams, M Basa, L Ayton, E Bowman, RK Shepherd, CE Williams

Conference Proceedings  |  2011

Gene therapy for the inner ear – achievements and challenges for clinical translation

RT Richardson, AK Wise, T Tu, PJ Atkinson, CR Hume, BO Flynn, BE Sgro, SJ O’Leary, RK Shepherd

Conference Proceedings  |  2011

Mechanisms of synchronous activity in cerebellar Purkinje cells

Andrew K Wise, Nadia L Cerminara, Dilwyn E Marple-Horvat, Richard Apps

Journal article  |  2010  |  Journal of Physiology

Effects of Localized Neurotrophin Gene Expression on Spiral Ganglion Neuron Resprouting in the Deafened Cochlea

Andrew K Wise, Clifford R Hume, Brianna O Flynn, Yogesh S Jeelall, Courtney L Suhr, Beatrice E Sgro, Stephen J O'Leary, Robert K Shepherd, Rachael T Richardson

Journal article  |  2010  |  Molecular Therapy

Auditory deprivation and cochlear implants: Pathological, atrophic and plastic changes in the auditory system

R Shepherd, D Irvine, R Pujol, R Richardson, L Pettingill, AK Wise, J Fallon

Conference Proceedings  |  2010

Protection of spiral ganglion neurons with neurotrophins and chronic electrical stimulation

AK Wise, JB Fallon, AJ Neil, J Andrew, LN Pettingill, M Geaney, RK Shepherd

Conference Proceedings  |  2010

Auditory neuron survival following implantation of encapsulated BDNF expressing Schwann cells into the deaf guinea pig cochlea

LN Pettingill, AK Wise, M Geaney, RK Shepherd

Conference Proceedings  |  2010

Gene transfer for directing the growth of auditory neurons after deafness

RT Richardson, AK Wise, T Tu, PJ Atkinson, CR Hume, BO Flynn, BE Sgro, SJ O’Leary, RK Shepherd

Conference Proceedings  |  2010

The effects of encapsulated BDNF-Schwann cells on auditory neuron survival In deafness.

LN Pettingill, AK Wise, M Geaney, RK Shepherd

Conference Proceedings  |  2010

Gene Therapy for the Preservation and Regeneration of Auditory Neurons After Deafness

PJ Atkinson, AK Wise, T Tu, BO Flynn, B Nayagam, RT Richardson

Conference Proceedings  |  2010

Gene therapy for the preservation and regeneration of auditory neurons after deafness

PJ Atkinson, AK Wise, BO Flynn, B Nayagam, RT Richardson

Conference Proceedings  |  2010  |  Proceedings of The Art, Science and future of Otorhinolaryngology: Frontiers 2010

The role of influenza virus in pneumococal otitis media: new insights from a novel infant mouse model

KR Short, DA Diavatopoulos, PC Reading, AK Wise, OL Wijburg

Conference Proceedings  |  2010

Chronic neurotrophin infusion and electrical stimulation in the deaf cochlea: Implications for cochlear implant spatial selectivity

TG Landry, AK Wise, JB Fallon, RK Shepherd

Conference Proceedings  |  2010

Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons

Rachael T Richardson, Andrew K Wise, Brianna C Thompson, Brianna O Flynn, Patrick J Atkinson, Nicole J Fretwell, James B Fallon, Gordon G Wallace, Rob K Shepherd, Graeme M Clark, Stephen J O'Leary

Journal article  |  2009  |  Biomaterials

Protection of spiral ganglion neurons with neurotrophins and chronic electrical stimulation

AK Wise, JB Fallon, AJ Evans, J Andrew, LN Pettingill, M Geaney, RK Shepherd

Conference Proceedings  |  2009

The response of auditory neurons to multichannel electrical stimulation in the deaf and chronically stimulated cochlea

AK Wise, JB Fallon, SJ O'Leary, DJ Sly, RK Shepherd

Conference Proceedings  |  2009

Protection of spiral ganglion neurons with neurotrophins and chronic electrical stimulation

AK Wise, JB Fallon, AJ Evans, J Andrew, LN Pettingill, M Geaney, RK Shepherd

Conference Proceedings  |  2009

Effects of localized neurotrophin gene therapy on auditory neurons after hearing loss

RT Richardson, AK Wise, CR Hume, BO Flynn, YS Jeelall, CL Suhr, BE Sgro, SJ O'Leary, RK Shepherd

Conference Proceedings  |  2009

Temporal and spatial characteristics of auditory neurons following deafness and chronic electrical stimulation

AK Wise, JB Fallon, SJ O'Leary, DJ Sly, RK Shepherd

Conference Proceedings  |  2009

Localized neurotrophin gene therapy for controlling auditory nerve regeneration after hearing loss

RT Richardson, AK Wise, CR Hume, BO Flynn, YS Jeelall, CL Suhr, BE Sgro, SJ O'Leary, RK Shepherd

Conference Proceedings  |  2009

Protection of spiral ganglion neurons with neurotrophins and chronic electrical stimulation

AK Wise, JB Fallon, AJ Evans, J Andrew, LN Pettingill, M Geaney, RK Shepherd

Conference Proceedings  |  2009

The effects of deafness and chronic electrical stimulation on the spatial and temporal characteristics of auditory neurons

AK Wise, JB Fallon, SJ O'Leary, DJ Sly, RK Shepherd

Conference Proceedings  |  2009

Novel drug delivery systems for inner ear protection and regeneration after hearing loss

Rachael T Richardson, Andrew K Wise, Jacqueline K Andrew, Stephen J O'Leary

Journal article  |  2008  |  Expert Opinion on Drug Delivery

Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons

RT Richardson, AK Wise, B Thompson, BO Flynn, JB Fallon, G Wallace, RK Shepherd, G Clark, SJ O'Leary

Conference Proceedings  |  2008

Factors affecting neural response telemetry recordings in the chronically stimulated cat

JB Fallon, AK Wise, RK Shepherd

Conference Proceedings  |  2008

Delivery strategies for neurotrophin delivery into the inner ear for Sgn protection following deafness.

RK Shepherd, A Coco, J Andrew, AK Wise, L Pettingill

Conference Proceedings  |  2008

Gene therapy for targeted regeneration of auditory neurons after hearing loss.

BO Flynn, AK Wise, P Atkinson, YS Jeelall, RK Shepherd, SJ O'Leary, RT Richardson

Conference Proceedings  |  2008

Factors affecting neural response telemetry recordings in the chronically stimulated cat

AK Wise, JB Fallon, JM Heasman, RK Shepherd

Conference Proceedings  |  2008

Polymer-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons

RT Richardson, AK Wise, B Thompson, BO Flynn, R Millard, JB Fallon, RK Shepherd, G Clark, G Wallace, SJ O'Leary

Conference Proceedings  |  2008

Spatial and temporal characteristic of auditory neurons in response to deafness and chronic electrical stimulation

AK Wise, JB Fallon, SJ O'Leary, DJ Sly, RK Shepherd

Conference Proceedings  |  2008

Gene transfer for directing growth of regenerating neurons after deafness

BO Flynn, AK Wise, P Atkinson, YS Jeelall, RK Shepherd, SJ O'Leary, RT Richardson

Conference Proceedings  |  2008

Drug delivery via intelligent polymers: Auditory nerve rescue for bionic ears

RT Richardson, AK Wise, B Thompson, BO Flynn, JB Fallon, G Wallace, G Clark, SJ O'Leary

Conference Proceedings  |  2008

Medical bionics and neurotrophin delivery: Staring at an intersection of two emerging disciplines.

RK Shepherd, A Coco, J Andrew, AK Wise, J Xu, L Pettingill

Conference Proceedings  |  2008

Effects of exogenous neurotrophins in the deaf stimulated cochlea

TG Landry, JB Fallon, AK Wise, RK Shepherd

Conference Proceedings  |  2008

Deafness alters auditory nerve fibre responses to cochlear implant stimulation

David J Sly, Leon F Heffer, Mark W White, Robert K Shepherd, Michael GJ Birch, Ricki L Minter, Niles E Nelson, Andrew K Wise, Stephen J O'Leary

Journal article  |  2007  |  European Journal of Neuroscience

Neurotrophic factors and neural prostheses: Potential clinical applications based upon findings in the auditory system

Lisa N Pettingill, Rachael T Richardson, Andrew K Wise, Stephen J O'Leary, Robert K Shepherd

Journal article  |  2007  |  IEEE Transactions on Biomedical Engineering

Joining the cochlear implant and the auditory nerve - dendritic growth on polymers

RT Richardson, AK Wise, B Thompson, BO Flynn, N Fretwell, JB Fallon, G Wallace, RK Shepherd, G Clark, SJ O'Leary

Conference Proceedings  |  2007

Polypyrrole/NT3-coated cochlear implant electrodes promote nerve survival and growth

RT Richardson, B Thompson, S Moulton, C Newbold, AK Wise, BO Flynn, R Kapsa, G Wallace, G Clark, SJ O'Leary

Conference Proceedings  |  2007

Neurotrophins and electrical stimulation for protection and repair following sensorineural hearing loss

RK Shepherd, A Coco, J Andrew, AK Wise, L Pettingill

Conference Proceedings  |  2007

Intracochlear stimulation in the mouse

AK Wise, J Xu, JB Fallon, RK Shepherd

Conference Proceedings  |  2007

Neurofilament proteins in the cochlea: Changes in response to deafening and neurotrophin administration

AK Wise, LN Pettingill, RT Richardson

Book Chapter  |  2007

Drug delivery to the cochlea: drug distribution and experimental delivery methods

RT Richardson, AK Wise, J Hardman, B Thompson, S Moulton, R Kapsa, G Wallace, G Clark, SJ O'Leary

Conference Proceedings  |  2006

Connecting the auditory nerve to its target in vivo: regeneration of the peripheral dendrite

AK Wise, RT Richardson, J Hardman, G Clark, SJ O'Leary

Conference Proceedings  |  2006

Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3

AK Wise, R Richardson, J Hardman, G Clark, S O'Leary

Journal article  |  2005  |  Journal of Comparative Neurology

A single dose of neurotrophin-3 to the cochlea surrounds spiral ganglion neurons and provides trophic support

RT Richardson, S O'Leary, A Wise, J Hardman, G Clark

Journal article  |  2005  |  Hearing Research

Simple spike synchrony in Purkinje cell pairs located within and between cerebellar cortical zones

AK Wise, DE Marple-Horvat, R Apps

Conference Proceedings  |  2005

Local effects of neurotrophins on peripheral processes of auditory neurons

RT Richardson, AK Wise, J Hardman, SJ O'Leary, G Clark

Conference Proceedings  |  2005

Local effects of neurotrophins on the peripheral processes of auditory neurons

RT Richardson, AK Wise, J Hardman, G Clark, SJ O'Leary

Conference Proceedings  |  2005

Tracing neurotrophin-3 diffusion and uptake in the guinea pig cochlea

RT Richardson, A Wise, S O'Leary, J Hardman, D Casley, G Clark

Journal article  |  2004  |  Hearing Research

Effects of hearing status upon probabilistic firing of the electrically excited auditory nerve

D Sly, L Heffer, M White, M Birch, RK Shepherd, AK Wise, SJ O'Leary

Conference Proceedings  |  2004

Simultaneous recordings of single Purkinje cells within and between cerebellar zones

AK Wise, DE Marple-Horvat, R Apps

Conference Proceedings  |  2004

Improving the nerve excitation capabilities of the cochlear implant

RT Richardson, SJ O'Leary, AK Wise, F Noushi, J Hardman, G Clark

Conference Proceedings  |  2004

Cochlear immunochemistry - a new technique based on gelatin embedding

PA Hurley, M Clarke, JM Crook, AK Wise, RK Shepherd

Journal article  |  2003  |  Journal of Neuroscience Methods

A New Technique for Optimal Cochlear Immunochemistry

PA Hurley, MM Clarke, JM Crook, AK Wise, RK Shepherd

Conference Proceedings  |  2003

Cellular targets and effects of neurotrophin delivered to the cochlea

AK Wise, RT Richardson, J Hardman, G Clark, SJ O'Leary

Conference Proceedings  |  2003

Effects of deafness upon probabilistic firing of the electrically excited auditory nerve.

D Sly, L Heffer, M White, M Birch, RK Shepherd, AK Wise, SJ O'Leary

Conference Proceedings  |  2003

Determining the fate of neurotrophins delivered to the scala tympani of normal and deafened guinea pigs

RT Richardson, AK Wise, H J., D Casley, G Clark, SJ O'Leary

Conference Proceedings  |  2003

Independence of auditory neuronal spiking at low discharge rate probabilities

SJ O'Leary, D Sly, L Heffer, M White, AK Wise, RK Shepherd, M Birch

Conference Proceedings  |  2003

The effect of muscle contraction on kinaesthesia

AK Wise, JB Fallon

Book Chapter  |  2002  |  Advances in Experimental Medicine and Biology

Fatigue in mammalian skeletal muscle stimulated under computer control

AK Wise, DL Morgan, JE Gregory, U Proske

Journal article  |  2001  |  Journal of Applied Physiology

Tension changes in the cat soleus muscle following slow stretch or shortening of the contracting muscle

DL Morgan, NP Whitehead, AK Wise, JE Gregory, U Proske

Journal article  |  2000  |  The Journal of Physiology

The role of muscle receptors in the detection of movements

U Proske, AK Wise, JE Gregory

Journal article  |  2000  |  Progress in Neurobiology

Minimising muscle fatigue using computer-controlled stimulation

AK Wise, JE Gregory, DL Morgan, U Proske

Conference Proceedings  |  2000

Reducing muscle fatigue using computer-controlled stimulation

AK Wise, CJ Scott, JE Gregory, DL Morgan, U Proske

Conference Proceedings  |  2000

A new strategy for controlling the level of activation in artificially stimulated muscle.

TI Brown, Y Huang, DL Morgan, U Proske, A Wise

Journal article  |  1999  |  IEEE Transactions on Rehabilitation Engineering

Distributed stimulation of slow skeletal muscle has previously been used to produce smooth tetanic contractions at low stimulus ra..

The responses of muscle spindles to small, slow movements in passive muscle and during fusimotor activity

AK Wise, JE Gregory, U Proske

Journal article  |  1999  |  Brain Research

Movement detection thresholds at the human elbow joint

U Proske, AK Wise, JE Gregory

Book Chapter  |  1999  |  Progress in Brain Research

Distributed stimulation of skeletal muscle

DL Morgan, Y Huang, AK Wise, U Proske, TI Brown

Conference Proceedings  |  1999

Muscle history fusimotor activity and the human stretch reflex

JE Gregory, AK Wise, SA Wood, A Prochazka, U Proske

Journal article  |  1998  |  The Journal of Physiology

Detection of movements of the human forearm during and after co-contractions of muscles acting at the elbow joint

AK Wise, JE Gregory, U Proske

Journal article  |  1998  |  The Journal of Physiology

The effective electrical activation of skeletal muscle

Y Huang, TIH Brown, DL Morgan, U Proske, A Wise

Conference Proceedings  |  1998  |  Proceedings of the 2nd International Conference on Bioelectromagnetism (Cat. No.98TH8269)

Muscle spindles: responses to fusimotor stimulation and the implications for proprioception

U Proske, AK Wise, JE Gregory

Conference Proceedings  |  1998

Fusimotor activity, muscle history and the human stretch reflex

JE Gregory, AK Wise, SA Wood, A Prochazka, U Proske

Conference Proceedings  |  1998

The effects of muscle conditioning on movement detection thresholds at the human forearm

AK Wise, JE Gregory, U Proske

Journal article  |  1996  |  Brain Research