Robert Shepherd

Platinum dissolution and tissue response following long-term electrical stimulation at high charge densities

Robert K Shepherd, Paul M Carter, Ashley N Dalrymple, Ya Lang Enke, Andrew K Wise, Trung Nguyen, James Firth, Alex Thompson, James B Fallon

Journal article  |  2021  |  JOURNAL OF NEURAL ENGINEERING

OBJECTIVE: Established guidelines for safe levels of electrical stimulation for neural prostheses are based on a limited range of ..

A Tissue Engineering Chamber for Continuous Pulsatile Electrical Stimulation of Vascularized Cardiac Tissues In Vivo.

Damián Hernández, Rodney Millard, Anne M Kong, Owen Burns, Priyadharshini Sivakumaran, Robert K Shepherd, Gregory J Dusting, Shiang Y Lim

Journal article  |  2020  |  Bioelectricity

Background: Cardiomyocytes derived from pluripotent stem cells are immature. Maturation of cardiomyocytes is a multifactorial dyna..

Chronic intracochlear electrical stimulation at high charge densities: reducing platinum dissolution

Robert K Shepherd, Paul M Carter, Ya Lang Enke, Alex Thompson, Brianna Flynn, Ella P Trang, Ashley N Dalrymple, James B Fallon

Journal article  |  2020  |  JOURNAL OF NEURAL ENGINEERING

OBJECTIVE: Cochleae of long-term cochlear implant users have shown evidence of particulate platinum (Pt) corroded from the surface..

In vivofeasibility of epiretinal stimulation using ultrananocrystalline diamond electrodes

Mohit N Shivdasani, Mihailo Evans, Owen Burns, Jonathan Yeoh, Penelope J Allen, David AX Nayagam, Joel Villalobos, Carla J Abbott, Chi D Luu, Nicholas L Opie, Anu Sabu, Alexia L Saunders, Michelle McPhedran, Lisa Cardamone, Ceara McGowan, Vanessa Maxim, Richard A Williams, Kate E Fox, Rosemary Cicione, David J Garrett, et al.

Journal article  |  2020  |  JOURNAL OF NEURAL ENGINEERING

OBJECTIVE: Due to their increased proximity to retinal ganglion cells (RGCs), epiretinal visual prostheses present the opportunity..

Guest editorial: Medical bionics: from emerging technologies to clinical practice

Robert K Shepherd

Journal article  |  2020  |  HEALTHCARE TECHNOLOGY LETTERS

Electrochemical and biological characterization of thin-film platinum-iridium alloy electrode coatings: a chronic in vivo study

Ashley N Dalrymple, Mario Huynh, Bryony A Nayagam, Curtis D Lee, Greg R Weiland, Artin Petrossians, J John, III Whalen, James B Fallon, Robert K Shepherd

Journal article  |  2020  |  JOURNAL OF NEURAL ENGINEERING

OBJECTIVE: To evaluate the electrochemical properties, biological response, and surface characterization of an electrodeposited Pl..

Electrochemical and biological performance of chronically stimulated conductive hydrogel electrodes

Ashley N Dalrymple, Ulises A Robles, Mario Huynh, Bryony A Nayagam, Rylie A Green, Laura A Poole-Warren, James B Fallon, Robert K Shepherd

Journal article  |  2020  |  JOURNAL OF NEURAL ENGINEERING

OBJECTIVE: Evaluate electrochemical properties, biological response, and surface characterization of a conductive hydrogel (CH) co..

Transmural impedance detects graded changes of inflammation in experimental colitis

Sophie C Payne, Jack Alexandrovics, Ross Thomas, Robert K Shepherd, John B Furness, James B Fallon

Journal article  |  2020  |  ROYAL SOCIETY OPEN SCIENCE

Ulcerative colitis is a chronic disease in which the mucosa of the colon or rectum becomes inflamed. An objective biomarker of inf..

Electrochemical and mechanical performance of reduced graphene oxide, conductive hydrogel, and electrodeposited Pt-Ir coated electrodes: an active in vitro study

Ashley N Dalrymple, Mario Huynh, Ulises Aregueta Robles, Jason B Marroquin, Curtis D Lee, Artin Petrossians, John J Whalen, Dan Li, Helena C Parkington, John S Forsythe, Rylie A Green, Laura A Poole-Warren, Robert K Shepherd, James B Fallon

Journal article  |  2020  |  JOURNAL OF NEURAL ENGINEERING

OBJECTIVE: To systematically compare the in vitro electrochemical and mechanical properties of several electrode coatings that hav..

Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes

Jeremy L Pinyon, Georg von Jonquieres, Edward N Crawford, Mayryl Duxbury, Amr Al Abed, Nigel H Lovell, Matthias Klugmann, Andrew K Wise, James B Fallon, Robert K Shepherd, Catherine S Birman, Waikong Lai, David McAlpine, Catherine McMahon, Paul M Carter, Ya Lang Enke, James F Patrick, Anne GM Schilder, Corinne Marie, Daniel Scherman, et al.

Journal article  |  2019  |  HEARING RESEARCH

This Review outlines the development of DNA-based therapeutics for treatment of hearing loss, and in particular, considers the pot..