Sally Beard

Nicotinamide and its effects on endothelial dysfunction and secretion of antiangiogenic factors by primary human placental cells and tissues

Fiona Brownfoot, Natalie Binder, Roxanne Hastie, Alesia Harper, Sally Beard, Laura Tuohey, Emerson Keenan, Stephen Tong, Natalie Hannan

Journal article  |  2021  |  PLACENTA

Preeclampsia is a serious pregnancy complication associated with elevated antiangiogenic markers and endothelial dysfunction. Rece..

Novel approaches to combat preeclampsia: from new drugs to innovative delivery

Natasha de Alwis, Natalie K Binder, Sally Beard, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Fiona Brownfoot, Natalie J Hannan

Journal article  |  2020  |  PLACENTA

Preeclampsia is a complex disease affecting 2-8% of pregnancies worldwide. It poses significant risk of maternal and perinatal mor..

Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia

Natalie K Binder, Fiona C Brownfoot, Sally Beard, Ping Cannon, Tuong V Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article  |  2020  |  PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH

Development and repurposing of therapies that show promise in the prevention or treatment of preeclampsia would be a major advance..

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction

Sally Beard, Natasha Pritchard, Natalie Binder, Karen Schindler, Natasha De Alwis, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Natalie J Hannan

Journal article  |  2020  |  PLACENTA

INTRODUCTION: Oxidative damage and biochemical ageing are implicated in placental dysfunction and potentially fetal death. Cellula..

Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth

Natalie J Hannan, Owen Stock, Rebecca Spencer, Clare Whitehead, Anna L David, Katie Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Lavinia Gordon, Sally Beard, Kantaraja Chindera, Smita Karegodar, Richard Hiscock, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Stephen Tong

Journal article  |  2020  |  BMC MEDICINE

Background Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricted..

Pravastatin as the statin of choice for reducing pre-eclampsia-associated endothelial dysfunction

Natasha de Alwis, Sally Beard, Yeukai T Mangwiro, Natalie K Binder, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Stephen Tong, Natalie J Hannan

Journal article  |  2020  |  PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH

OBJECTIVES: There is avid interest in pravastatin as a therapeutic intervention for pre-eclampsia, however little is known on stat..

The New Generation Antiplatelet Agent Prasugrel Represents an Exciting Novel Candidate Therapy for Preeclampsia.

Natasha De Alwis, Natalie Binder, Sally Beard, Nguyen Vi, Kaitu'u-Lino Tu'uhevaha, Stephen Tong, Natalie Hannan

Conference Proceedings  |  2020  |  REPRODUCTIVE SCIENCES

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women A Swedish Population Register-Based Cohort Study

Roxanne Hastie, Lina Bergman, Catherin A Cluver, Anna Wikman, Natalie J Hannan, Susan P Walker, Anna-Karin Wikstrom, Stephen Tong, Susanne Hesselman

Journal article  |  2019  |  HYPERTENSION

Preeclampsia is a hypertensive disorder of pregnancy characterized by maternal endothelial dysfunction and end-organ damage. The a..

Comparing the Ability of Pravastatin, Simvastatin and Rosuvastatin to Quench Markers of Endothelial Dysfunction in Pregnancy.

Natasha de Alwis, Sally Beard, Natalie Binder, Tu'uhevaha Kaitu'u-Lino, Fiona Brownfoot, Stephen Tong, Natalie Hannan

Conference Proceedings  |  2019  |  REPRODUCTIVE SCIENCES

New Generation Antiplatelet Agents Mitigate Pathophysiological Aspects of Preeclampsia in Both Human and Mouse Models of Preeclampsia, Representing Exciting Novel Candidate Therapeutics.

Natalie Hannan, Sally Beard, Natalie Binder, Natasha De Alwis, Natasha Pritchard, Tu'uhevaha Kaitu'u-Lino, Stephen Tong

Conference Proceedings  |  2019  |  REPRODUCTIVE SCIENCES