Normand Pouliot

Efficacy of neratinib neoadjuvant therapy in a pre-clinical model of HER2( ve) breast cancer brain metastasis

Aadya Nagpal, Rick P Redvers, Scott Ayton, Robin Anderson, Sherene Loi, Normand Pouliot

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2( ve) breast cancer metastasis

Aadya Nagpal, Richard P Redvers, Xiawei Ling, Scott Ayton, Miriam Fuentes, Elnaz Tavancheh, Irmina Diala, Alshad Lalani, Sherene Loi, Steven David, Robin L Anderson, Yvonne Smith, Delphine Merino, Delphine Denoyer, Normand Pouliot

Journal article  |  2019  |  BREAST CANCER RESEARCH

BACKGROUND: Human epidermal growth factor receptor-2 (HER2)-targeted therapies prolong survival in HER2-positive breast cancer pat..

Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis

Soo-Hyun Kim, Richard P Redvers, Lap Hing Chi, Xiawei Ling, Andrew J Lucke, Robert C Reid, David P Fairlie, Ana Carolina Baptista Moreno Martin, Robin L Anderson, Delphine Denoyer, Normand Pouliot

Journal article  |  2018  |  DISEASE MODELS & MECHANISMS

Breast cancer brain metastases remain largely incurable. Although several mouse models have been developed to investigate the gene..

EpCAM Immunotherapy versus Specific Targeted Delivery of Drugs

Joanna Macdonald, Justin Henri, Kislay Roy, Emma Hays, Michelle Bauer, Rakesh Naduvile Veedu, Normand Pouliot, Sarah Shigdar

Journal article  |  2018  |  CANCERS

The epithelial cell adhesion molecule (EpCAM), or CD326, was one of the first cancer associated biomarkers to be discovered. In th..

[10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo

Ana Carolina BM Martin, Angelina M Fuzer, Amanda B Becceneri, James Almada da Silva, Rebeka Tomasin, Delphine Denoyer, Soo-Hyun Kim, Katherine A McIntyre, Helen B Pearson, Belinda Yeo, Aadya Nagpal, Xiawei Ling, Heloisa S Selistre-de-Araujo, Paulo Cezar Vieira, Marcia R Cominetti, Normand Pouliot

Journal article  |  2017  |  ONCOTARGET

There is increasing interest in the use of non-toxic natural products for the treatment of various pathologies, including cancer. ..

Sulfonation of Tyrosine as a Method To Improve Biodistribution of Peptide-Based Radiotracers: Novel F-18-Labeled Cyclic RGD Analogues

Mohammad B Haskali, Delphine Denoyer, Wayne Noonan, Carleen Culinane, Christine Rangger, Normand Pouliot, Roland Haubner, Peter D Roselt, Rodney J Hicks, Craig A Hutton

Journal article  |  2017  |  MOLECULAR PHARMACEUTICS

Control of the biodistribution of radiolabeled peptides has proven to be a major challenge in their application as imaging agents ..

Cancer cell CCL5 mediates bone marrow independent angiogenesis in breast cancer

Michael John Sax, Christin Gasch, Vineel Rag Athota, Ruth Freeman, Parisa Rasighaemi, David Elton Westcott, Christopher John Day, Iva Nikolic, Benjamin Elsworth, Ming Wei, Kelly Rogers, Alexander Swarbrick, Vivek Mittal, Normand Pouliot, Albert Sleiman Mellick

Journal article  |  2016  |  ONCOTARGET

It has recently been suggested that the chemokine receptor (CCR5) is required for bone marrow (BM) derived endothelial progenitor ..

Tumour but not stromal expression of beta 3 integrin is essential, and is required early, for spontaneous dissemination of bone-metastatic breast cancer

Rachel Zoe Carter, Kelli Cristina Micocci, Anthony Natoli, Richard Paul Redvers, Sophie Paquet-Fifield, Ana Carolina Baptista Moreno Martin, Delphine Denoyer, Xiawei Ling, Soo-Hyun Kim, Rebeka Tomasin, Heloisa Selistre-de-Araujo, Robin Lesley Anderson, Normand Pouliot

Journal article  |  2015  |  JOURNAL OF PATHOLOGY

Although many preclinical studies have implicated β3 integrin receptors (αvβ3 and αIIbβ3) in cancer progression, β3 inhibitors hav..

Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer

Cameron N Johnstone, Yvonne E Smith, Yuan Cao, Allan D Burrows, Ryan SN Cross, Xiawei Ling, Richard P Redvers, Judy P Doherty, Bedrich L Eckhardt, Anthony L Natoli, Christina M Restall, Erin Lucas, Helen B Pearson, Siddhartha Deb, Kara L Britt, Alexandra Rizzitelli, Jason Li, Judith H Harmey, Normand Pouliot, Robin L Anderson

Journal article  |  2015  |  DISEASE MODELS & MECHANISMS

The translation of basic research into improved therapies for breast cancer patients requires relevant preclinical models that inc..

Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity

Itsuhiro Takizawa, Mitchell G Lawrence, Preetika Balanathan, Richard Rebello, Helen B Pearson, Elika Garg, John Pedersen, Normand Pouliot, Robert Nadon, Matthew J Watt, Renea A Taylor, Patrick Humbert, Ivan Topisirovic, Ola Larsson, Gail P Risbridger, Luc Furic

Journal article  |  2015  |  ONCOTARGET

While high doses of estrogen, in combination with androgens, can initiate prostate cancer (PCa) via activation of the estrogen rec..