Normand Pouliot

Integrin alpha v beta 3 Is a Master Regulator of Resistance to TKI-Induced Ferroptosis in HER2-Positive Breast Cancer

Aadya Nagpal, Kristen Needham, Darius JR Lane, Scott Ayton, Richard P Redvers, Melissa John, Heloisa S Selistre-de-Araujo, Delphine Denoyer, Normand Pouliot

Journal article  |  2023  |  CANCERS

Human epidermal growth factor receptor-2 (HER2)-targeting therapies provide clinical benefits for patients with HER2-positive brea..

Bifunctional Aptamer-Doxorubicin Conjugate Crosses the Blood-Brain Barrier and Selectively Delivers Its Payload to EpCAM-Positive Tumor Cells

Joanna Macdonald, Delphine Denoyer, Justin Henri, Adelaide Jamieson, Ingrid JG Burvenich, Normand Pouliot, Sarah Shigdar

Journal article  |  2020  |  NUCLEIC ACID THERAPEUTICS

The prognosis for breast cancer patients diagnosed with brain metastases is poor, with survival time measured merely in months. Th..

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition

Prahlad Raninga, Andy Lee, Debottam Sinha, Lan-feng Dong, Keshava Datta, Xue Lu, Priyakshi Kalita-de Croft, Mriga Dutt, Michelle M Hill, Normand M Pouliot, Harsha Gowda, Murugan Kalimutho, Jiri Neuzil, Kum Kum Khanna

Journal article  |  2020  |  THERANOSTICS

Purpose: Lacking effective targeted therapies, triple-negative breast cancer (TNBCs) is highly aggressive and metastatic disease, ..

Efficacy of neratinib neoadjuvant therapy in a pre-clinical model of HER2( ve) breast cancer brain metastasis

Aadya Nagpal, Rick P Redvers, Scott Ayton, Robin Anderson, Sherene Loi, Normand Pouliot

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2( ve) breast cancer metastasis

Aadya Nagpal, Richard P Redvers, Xiawei Ling, Scott Ayton, Miriam Fuentes, Elnaz Tavancheh, Irmina Diala, Alshad Lalani, Sherene Loi, Steven David, Robin L Anderson, Yvonne Smith, Delphine Merino, Delphine Denoyer, Normand Pouliot

Journal article  |  2019  |  BREAST CANCER RESEARCH

BACKGROUND: Human epidermal growth factor receptor-2 (HER2)-targeted therapies prolong survival in HER2-positive breast cancer pat..

Limitrin (DICAM): a new prognostic biomarker and therapeutic target for breast cancer brain metastasis

D Denoyer, SH Kim, RP Redvers, A Nagpal, M Fuentes, R Anderson, N Pouliot

Conference Proceedings  |  2019  |  CLINICAL & EXPERIMENTAL METASTASIS

Evaluation of Neratinib efficacy and mechanisms of resistance in a new syngeneic model of spontaneous breast cancer brain metastasis

A Nagpal, RP Redvers, D Denoyer, SJ Ayton, H de Araujo, M Fuentes, E Mouhtouris, R Anderson, S Loi, S David, N Pouliot

Conference Proceedings  |  2019  |  CLINICAL & EXPERIMENTAL METASTASIS

A novel approach to overcome resistance to HER2 targeted therapy in a new syngeneic model of breast cancer brain metastasis

Normand Pouliot, Aadya Nagpal, Miriam Fuentes, Effie Mouhtouris, Francesca Avogadri-Connors, Alshad S Lalani, Heloisa Sobreiro Selistre de Araujo

Conference Proceedings  |  2018  |  CANCER RESEARCH

Abstract The human epidermal growth factor receptor-2 (HER2) subtype of breast cancer is aggressive and associated ..

Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis

Soo-Hyun Kim, Richard Redvers, Lap Hing Chi, Xiawei Ling, Andrew Lucke, Robert Reid, David Fairlie, Ana Carolina Baptista Moreno Martin, Robin Anderson, Delphine Denoyer, Normand Pouliot

Journal article  |  2018  |  Disease Models & Mechanisms

Breast cancer brain metastasis remains largely incurable. While several mouse models have been developed to investigate the genes ..

EpCAM Immunotherapy versus Specific Targeted Delivery of Drugs

Joanna Macdonald, Justin Henri, Kislay Roy, Emma Hays, Michelle Bauer, Rakesh Naduvile Veedu, Normand Pouliot, Sarah Shigdar

Journal article  |  2018  |  CANCERS

The epithelial cell adhesion molecule (EpCAM), or CD326, was one of the first cancer associated biomarkers to be discovered. In th..