Belinda Parker

Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone

Katie L Owen, Linden J Gearing, Damien J Zanker, Natasha K Brockwell, Weng Hua Khoo, Daniel L Roden, Marek Cmero, Stefano Mangiola, Matthew K Hong, Alex J Spurling, Michelle McDonald, Chia-Ling Chan, Anupama Pasam, Ruth J Lyons, Hendrika M Duivenvoorden, Andrew Ryan, Lisa M Butler, John M Mariadason, Tri Giang Phan, Vanessa M Hayes, et al.

Journal article  |  2020  |  EMBO Reports

The latency associated with bone metastasis emergence in castrate-resistant prostate cancer is attributed to dormancy, a state in ..

Preliminary study highlights the potential of immune checkpoint inhibitors in sarcomatoid mesothelioma

Natasha K Brockwell, Muhammad Alamgeer, Beena Kumar, Gareth Rivalland, Thomas John, Belinda S Parker

Journal article  |  2020  |  Translational Lung Cancer Research

Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis

Bedrich L Eckhardt, Yuan Cao, Andrew D Redfern, Lap Hing Chi, Allan D Burrows, Suraya Roslan, Erica K Sloan, Belinda S Parker, Sherene Loi, Naoto T Ueno, Peter KH Lau, Bruce Latham, Robin L Anderson

Journal article  |  2020  |  Cancer Research

Metastasis is the major cause of death in patients with cancer; with no therapeutic cure, treatments remain largely palliative. As..

Intratumoral administration of the Toll-like receptor 7/8 agonist 3M-052 enhances interferon-driven tumor immunogenicity and suppresses metastatic spread in preclinical triple-negative breast cancer

Damien J Zanker, Alex J Spurling, Natasha K Brockwell, Katie L Owen, Jasmine M Zakhour, Tina Robinson, Hendrika M Duivenvoorden, Paul J Hertzog, Stefanie R Mullins, Robert W Wilkinson, Belinda S Parker

Journal article  |  2020  |  Clinical and Translational Immunology

Objectives: Loss of tumor-inherent type I interferon (IFN) signalling has been closely linked to accelerated metastatic progressio..

JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression

Katie L Owen, Natasha K Brockwell, Belinda S Parker

Journal article  |  2019  |  Cancers

Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates almost all immune regulatory processes..

Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice

Tanmay M Shekhar, Ingrid JG Burvenich, Michael A Harris, Angela Rigopoulos, Damien Zanker, Alex Spurling, Belinda S Parker, Carl R Walkley, Andrew M Scott, Christine J Hawkins

Journal article  |  2019  |  BMC Cancer

Tumor inherent interferon regulators as biomarkers of long-term chemotherapeutic response in TNBC

Natasha K Brockwell, Jai Rautela, Katie L Owen, Linden J Gearing, Siddhartha Deb, Kate Harvey, Alex Spurling, Damien Zanker, Chia-Ling Chan, Helen E Cumming, Niantao Deng, Jasmine M Zakhour, Hendrika M Duivenvoorden, Tina Robinson, Marion Harris, Michelle White, Jane Fox, Corinne Ooi, Beena Kumar, Jacqui Thomson, et al.

Journal article  |  2019  |  npj Precision Oncology

A niche-dependent myeloid transcriptome signature defines dormant myeloma cells

Weng Hua Khoo, Guy Ledergor, Assaf Weiner, Daniel L Roden, Rachael L Terry, Michelle M McDonald, Ryan C Chai, Kim De Veirman, Katie L Owen, Khatora S Opperman, Kate Vandyke, Justine R Clark, Anja Seckinger, Natasa Kovacic, Akira Nguyen, Sindhu T Mohanty, Jessica A Pettitt, Ya Xiao, Alexander P Corr, Christine Seeliger, et al.

Journal article  |  2019  |  Blood

The Emerging Role of Immunosurveillance in Dictating Metastatic Spread in Breast Cancer

Clare Y Slaney, Jai Rautela, Belinda S Parker

Journal article  |  2013  |  Cancer Research

Interferon-epsilon Protects the Female Reproductive Tract from Viral and Bacterial Infection

Ka Yee Fung, Niamh E Mangan, Helen Cumming, Jay C Horvat, Jemma R Mayall, Sebastian A Stifter, Nicole De Weerd, Laila C Roisman, Jamie Rossjohn, Sarah A Robertson, John E Schjenken, Belinda Parker, Caroline E Gargett, Hong PT Nguyen, Daniel J Carr, Philip M Hansbro, Paul J Hertzog

Journal article  |  2013  |  Science