Simon Royce

Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy

Nadia Mazarakis, Jitraporn Vongsvivut, Keith R Bambery, Katherine Ververis, Mark J Tobin, Simon G Royce, Chrishan S Samuel, Kenneth J Snibson, Paul V Licciardi, Tom C Karagiannis

Journal article  |  2020  |  Scientific Reports

The ovalbumin-induced (OVA) chronic allergic airways murine model is a well-established model for investigating pre-clinical thera..

Letter: intestinal inflammation, COVID-19 and gastrointestinal ACE2-exploring RAS inhibitors

Mayur Garg, Simon G Royce, John S Lubel

Journal article  |  2020  |  Alimentary Pharmacology and Therapeutics

We read with interest the article by Taxonera et al outlining a high incidence of diarrhoea in patients with inflammatory bowel di..

Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Duygu Batu, Elena Velkoska, Louise M Burrell, Sheila K Patel, Lauren Beswick, Anvesh Jackson, Kaushali Britto, Matthew Lukies, Pavel Sluka, Hady Wardan, Yumiko Hirokawa, Chin Wee Tan, Maree Faux, Antony W Burgess, Patrick Hosking, Shaun Monagle, et al.

Journal article  |  2020  |  Gut

OBJECTIVE: We evaluated the influence of the renin-angiotensin system (RAS) on intestinal inflammation and fibrosis. DESIGN: Cultu..

Serelaxin enhances the therapeutic effects of human amnion epithelial cell-derived exosomes in experimental models of lung disease

Simon G Royce, Krupesh P Patel, WeiYi Mao, Dandan Zhu, Rebecca Lim, Chrishan S Samuel

Journal article  |  2019  |  British Journal of Pharmacology

iPSC- and mesenchymoangioblast-derived mesenchymal stem cells provide greater protection against experimental chronic allergic airways disease compared with a clinically used corticosteroid

Simon G Royce, WeiYi Mao, Rebecca Lim, Kilian Kelly, Chrishan S Samuel

Journal article  |  2019  |  The FASEB Journal

The intestinal vitamin D receptor in inflammatory bowel disease: inverse correlation with inflammation but no relationship with circulating vitamin D status.

Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Pavel Sluka, Hady Wardan, Patrick Hosking, Shaun Monagle, Merlin Thomas, John S Lubel, Peter R Gibson

Journal article  |  2019  |  Therapeutic Advances in Gastroenterology

Background: The intestinal vitamin D receptor (VDR) remains poorly characterized in patients with inflammatory bowel disease (IBD)..

Intranasal administration of mesenchymoangioblast-derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease

Simon G Royce, Siddharth Rele, Brad RS Broughton, Kilian Kelly, Chrishan S Samuel

Journal article  |  2017  |  The FASEB Journal

Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease

Chantal Donovan, Simon R Bailey, Jenny Tran, Gertruud Haitsma, Zaridatul A Ibrahim, Simon R Foster, Mimi LK Tang, Simon G Royce, Jane E Bourke

Journal article  |  2015  |  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Alteration of Airway Reactivity and Reduction of Ryanodine Receptor Expression by Cigarette Smoke in Mice

Chantal Donovan, Huei Jiunn Seow, Simon G Royce, Jane E Bourke, Ross Vlahos

Journal article  |  2015  |  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Electrophysiological, Electroanatomical, and Structural Remodeling of the Atria as Consequences of Sustained Obesity

Rajiv Mahajan, Dennis H Lau, Anthony G Brooks, Nicholas J Shipp, Jim Manavis, John PM Wood, John W Finnie, Chrishan S Samuel, Simon G Royce, Darragh J Twomey, Shivshanker Thanigaimani, Jonathan M Kalman, Prashanthan Sanders

Journal article  |  2015  |  Journal of the American College of Cardiology