Simon Royce

Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy.

Nadia Mazarakis, Jitraporn Vongsvivut, Keith R Bambery, Katherine Ververis, Mark J Tobin, Simon G Royce, Chrishan S Samuel, Kenneth J Snibson, Paul V Licciardi, Tom C Karagiannis

Journal article  |  2020  |  Scientific Reports

The ovalbumin-induced (OVA) chronic allergic airways murine model is a well-established model for investigating pre-clinical thera..

Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Duygu Batu, Elena Velkoska, Louise M Burrell, Sheila K Patel, Lauren Beswick, Anvesh Jackson, Kaushali Britto, Matthew Lukies, Pavel Sluka, Hady Wardan, Yumiko Hirokawa, Chin Wee Tan, Maree Faux, Antony W Burgess, Patrick Hosking, Shaun Monagle, et al.

Journal article  |  2020  |  Gut

OBJECTIVE: We evaluated the influence of the renin-angiotensin system (RAS) on intestinal inflammation and fibrosis. DESIGN: Cultu..

Serelaxin enhances the therapeutic effects of human amnion epithelial cell-derived exosomes in experimental models of lung disease

Simon G Royce, Krupesh P Patel, WeiYi Mao, Dandan Zhu, Rebecca Lim, Chrishan S Samuel

Journal article  |  2019  |  British Journal of Pharmacology

iPSC- and mesenchymoangioblast-derived mesenchymal stem cells provide greater protection against experimental chronic allergic airways disease compared with a clinically used corticosteroid

Simon G Royce, WeiYi Mao, Rebecca Lim, Kilian Kelly, Chrishan S Samuel

Journal article  |  2019  |  The FASEB Journal

The intestinal vitamin D receptor in inflammatory bowel disease: inverse correlation with inflammation but no relationship with circulating vitamin D status

M Garg, SG Royce, C Tikellis, C Shallue, P Sluka, H Wardan, P Hosking, S Monagle, M Thomas, JS Lubel, PR Gibson

Journal article  |  2019  |  Therapeutic Advances in Gastroenterology

Intranasal administration of mesenchymoangioblast-derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease

Simon G Royce, Siddharth Rele, Brad RS Broughton, Kilian Kelly, Chrishan S Samuel

Journal article  |  2017  |  The FASEB Journal

Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease

Chantal Donovan, Simon R Bailey, Jenny Tran, Gertruud Haitsma, Zaridatul A Ibrahim, Simon R Foster, Mimi LK Tang, Simon G Royce, Jane E Bourke

Journal article  |  2015  |  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Alteration of Airway Reactivity and Reduction of Ryanodine Receptor Expression by Cigarette Smoke in Mice

Chantal Donovan, Huei Jiunn Seow, Simon G Royce, Jane E Bourke, Ross Vlahos

Journal article  |  2015  |  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Electrophysiological, Electroanatomical, and Structural Remodeling of the Atria as Consequences of Sustained Obesity

Rajiv Mahajan, Dennis H Lau, Anthony G Brooks, Nicholas J Shipp, Jim Manavis, John PM Wood, John W Finnie, Chrishan S Samuel, Simon G Royce, Darragh J Twomey, Shivshanker Thanigaimani, Jonathan M Kalman, Prashanthan Sanders

Journal article  |  2015  |  Journal of the American College of Cardiology

Novel therapeutic strategies for lung disorders associated with airway remodelling and fibrosis

Simon G Royce, Yuben Moodley, Chrishan S Samuel

Journal article  |  2014  |  Pharmacology and Therapeutics

Histone deacetylases and their inhibitors: new implications for asthma and chronic respiratory conditions

Simon G Royce, Tom C Karagiannis

Journal article  |  2014  |  Current Opinion in Allergy and Clinical Immunology

Mechanistic Insights into the Contribution of Epithelial Damage to Airway Remodeling Novel Therapeutic Targets for Asthma

Simon G Royce, Xuelei Li, Stephanie Tortorella, Liana Goodings, Bryna SM Chow, Andrew S Giraud, Mimi LK Tang, Chrishan S Samuel

Journal article  |  2014  |  American Journal of Respiratory Cell and Molecular Biology

Plasminogen-stimulated airway smooth muscle cell proliferation is mediated by urokinase and annexin A2, involving plasmin-activated cell signalling

AG Stewart, YC Xia, T Harris, S Royce, JA Hamilton, M Schuliga

Journal article  |  2013  |  BRITISH JOURNAL OF PHARMACOLOGY

Combination therapy with relaxin and methylprednisolone augments the effects of either treatment alone in inhibiting subepithelial fibrosis in an experimental model of allergic airways disease

Simon G Royce, Amelia Sedjahtera, Chrishan S Samuel, Mimi LK Tang

Journal article  |  2013  |  Clinical Science

Effects of the Histone Deacetylase Inhibitor, Trichostatin A, in a Chronic Allergic Airways Disease Model in Mice

Simon G Royce, William Dang, Gao Yuan, Jenny Tran, Assam El-Osta, Tom C Karagiannis, Mimi LK Tang

Journal article  |  2012  |  Archivum Immunologiae et Therapiae Experimntalis

Histone Deacetylase Inhibitors: Can We Consider Potent Anti-Neoplastic Agents for the Treatment of Asthma?

Simon G Royce, Katherine Ververis, Tom C Karagiannis

Journal article  |  2012  |  Annals of Clinical and Laboratory Science

The regulation of fibrosis in airway remodeling in asthma

Simon G Royce, Victor Cheng, Chrishan S Samuel, Mimi LK Tang

Journal article  |  2012  |  Molecular and Cellular Endocrinology

Histone Deacetylases and Their Role in Asthma

Simon G Royce, Tom C Karagiannis

Journal article  |  2012  |  Journal of Asthma (New York)

Molecular model of naphthalene-induced DNA damage in the murine lung

Tom C Karagiannis, Xuelei Li, Michelle M Tang, Christian Orlowski, Assam El-Osta, Mimi LK Tang, Simon G Royce

Journal article  |  2012  |  Human & Experimental Toxicology: an international journal

Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease

Simon G Royce, William Dang, Katherine Ververis, Nishika De Sampayo, Assam El Osta, Mimi LK Tang, Tom C Karagiannis

Journal article  |  2011  |  Epigenetics

Trefoil Factor 2 Regulates Airway Remodeling in Animal Models of Asthma

Simon G Royce, Clarice Lim, Ruth C Muljadi, Mimi LK Tang

Journal article  |  2011  |  Journal of Asthma (New York)

The role of SMAD4 in early-onset colorectal cancer

SG Royce, K Alsop, A Haydon, L Mead, LD Smith, AA Tesoriero, GG Giles, MA Jenkins, JL Hopper, MC Southey

Journal article  |  2010  |  Colorectal Disease

A novel foregut mucin characterized by a murine monoclonal autoantibody source.

S BINOS, S ROYCE, D OXLEY, A BACIC, P BHATHAL, J UNDERWOOD

Journal article  |  2010  |  Hybridoma

Relaxin Family Peptide Receptor-1 Protects against Airway Fibrosis during Homeostasis But Not against Fibrosis Associated with Chronic Allergic Airways Disease

C SAMUEL, S ROYCE, B Chen, H Cao, JA Gossen, G TREGEAR, M TANG

Journal article  |  2009  |  Endocrinology

Role of Relaxin in Regulation of Fibrosis in the Lung Implications for Airway Remodeling in Asthma

Mimi LK Tang, Chrishan S Samuel, Simon G Royce

Journal article  |  2009  |  Annals of The New York Academy of Sciences

Relaxin plays an important role in the regulation of airway structure and function

Chrishan S Samuel, Simon G Royce, Matthew D Burton, Chongxin Zhao, Geoffrey W Tregear, Mimi LK Tang

Journal article  |  2007  |  Endocrinology

Microsatellite instability markers for identifying early-onset colorectal cancers caused by germ-line mutations in DNA mismatch repair genes

Leeanne J Mead, Mark A Jenkins, Joanne Young, Simon G Royce, Letitia Smith, D James B St John, Finlay Macrae, Graham G Giles, John L Hopper, Melissa C Southey

Journal article  |  2007  |  CLINICAL CANCER RESEARCH

Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease

Natasha R Locke, Simon G Royce, Jacquetta S Wainewright, Chrishan S Samuel, Mimi L Tang

Journal article  |  2007  |  American Journal of Respiratory Cell and Molecular Biology

BRCA1 promoter deletions in young women with breast cancer and a strong family history: A population-based study

LD Smith, AA Tesoriero, SJ Ramus, G Dite, SG Royce, GG Giles, MRE McCredie, JL Hopper, MC Southey

Journal article  |  2007  |  European Journal of Cancer

Liver fluke-associated and sporadic cholangiocarcinoma: an immunohistochemical study of bile duct, peribiliary gland and tumour cell phenotypes

NR Hughes, C Pairojkul, SG Royce, A Clouston, PS Bhathal

Journal article  |  2006  |  Journal of Clinical Pathology

Large genomic alterations in hMSH2 and hMLH1 in early-onset colorectal cancer: identification of a large complex de novo hMLH1 alteration

L Smith, A Tesoriero, L Mead, S Royce, G Grubb, J Young, G Giles, M Jenkins, F Macrae, JL Hopper, MC Southey

Journal article  |  2006  |  Clinical Genetics

Low somatic K-ras mutation frequency in colorectal cancer diagnosed under the age of 45 years

Kathryn Alsop, Leeanne Mead, Letitia D Smith, Simon G Royce, Andrea A Tesoriero, Joanne P Young, Andrew Haydon, Garry Grubb, Graham G Giles, Mark A Jenkins, John L Hopper, Melissa C Southey

Journal article  |  2006  |  European Journal of Cancer

Endogenous Relaxin Regulates Collagen Deposition in an Animal Model of Allergic Airway Disease

Ishanee Mookerjee, Natasha R Solly, Simon G Royce, Geoffrey W Tregear, Chrishan S Samuel, Mimi LK Tang

Journal article  |  2006  |  Endocrinology

Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer

MC Southey, MA Jenkins, L Mead, J Whitty, M Trivett, AA Tesoriero, LD Smith, K Jennings, G Grubb, SG Royce, MD Walsh, MA Barker, JP Young, JR Jass, DJB St John, FA Macrae, GG Giles, JL Hopper

Journal article  |  2005  |  Journal of Clinical Oncology

Selective colonization by Helicobacter pylori of the deep gastric glands and intracellular canaliculi of parietal cells in the setting of chronic proton pump inhibitor use

PP Tagkalidis, SG Royce, FA Macrae, PS Bhathal

Journal article  |  2002  |  European Journal of Gastroenterology and Hepatology