Michael Hynes

Carbon Catabolite Repression Governs Diverse Physiological Processes and Development in Aspergillus nidulans.

Yingying Chen, Liguo Dong, Md Ashiqul Alam, Lakhansing Pardeshi, Zhengqiang Miao, Fang Wang, Kaeling Tan, Michael J Hynes, Joan M Kelly, Koon Ho Wong

Journal article  |  2021  |  mBio

Carbon catabolite repression (CCR) is a common phenomenon of microorganisms that enable efficient utilization of carbon nutrients,..

'Rapid transit' constipation in children: a possible genesis for irritable bowel syndrome

JM Hutson, MC Hynes, I Kearsey, YI Yik, DM Veysey, CF Tudball, TM Cain, SK King, BR Southwell

Journal article  |  2020  |  Pediatric Surgery International

Children with chronic idiopathic constipation (CIC) often end up at the surgeon when medical treatments have failed. This opinion ..

Dual DNA binding and coactivator functions of Aspergillus nidulansTamA, a Zn(II)2Cys6 transcription factor

Damien J Downes, Meryl A Davis, Koon Ho Wong, Sara D Kreutzberger, Michael J Hynes, Richard B Todd

Journal article  |  2014  |  MOLECULAR MICROBIOLOGY

Transcription factors containing DNA binding domains generally regulate transcription by direct interaction with DNA. For most tra..

Multiple Nuclear Localization Signals Mediate Nuclear Localization of the GATA Transcription Factor AreA

Cameron C Hunter, Kendra S Siebert, Damien J Downes, Koon Ho Wong, Sara D Kreutzberger, James A Fraser, David F Clarke, Michael J Hynes, Meryl A Davis, Richard B Todd

Journal article  |  2014  |  EUKARYOTIC CELL

The Aspergillus nidulans GATA transcription factor AreA activates transcription of nitrogen metabolic genes in response to nitroge..

Fungal siderophore biosynthesis is partially localized in peroxisomes

Mario Gruendlinger, Sabiha Yasmin, Beatrix Elisabeth Lechner, Stephan Geley, Markus Schrettl, Michael Hynes, Hubertus Haas

Journal article  |  2013  |  MOLECULAR MICROBIOLOGY

Siderophores play a central role in iron metabolism and virulence of most fungi. Both Aspergillus fumigatus and Aspergillus nidula..

HgrA is necessary and sufficient to drive hyphal growth in the dimorphic pathogen Penicillium marneffei

Hayley E Bugeja, Michael J Hynes, Alex Andrianopoulos

Journal article  |  2013  |  MOLECULAR MICROBIOLOGY

Fungi produce multiple morphological forms as part of developmental programs or in response to changing, often stressful, environm..

Reprogramming of carbon metabolism by the transcriptional activators AcuK and AcuM in Aspergillus nidulans

Yumi Suzuki, Sandra L Murray, Koon Ho Wong, Meryl A Davis, Michael J Hynes

Journal article  |  2012  |  MOLECULAR MICROBIOLOGY

The ability of fungi to use carbon sources metabolized via the TCA cycle requires gluconeogenesis. In Aspergillus nidulans the Acu..

AreA controls nitrogen source utilisation during both growth programs of the dimorphic fungus Penicillium marneffei

Hayley E Bugeja, Michael J Hynes, Alex Andrianopoulos

Journal article  |  2012  |  FUNGAL BIOLOGY

The opportunistic pathogen Penicillium marneffei displays a temperature-dependent dimorphic switching program with saprophytic hyp..

Role of Carnitine Acetyltransferases in Acetyl Coenzyme A Metabolism in Aspergillus nidulans

Michael J Hynes, Sandra L Murray, Alex Andrianopoulos, Meryl A Davis

Journal article  |  2011  |  EUKARYOTIC CELL

The flow of carbon metabolites between cellular compartments is an essential feature of fungal metabolism. During growth on ethano..

ATP-Citrate Lyase Is Required for Production of Cytosolic Acetyl Coenzyme A and Development in Aspergillus nidulans

Michael J Hynes, Sandra L Murray

Journal article  |  2010  |  EUKARYOTIC CELL

Acetyl coenzyme A (CoA) is a central metabolite in carbon and energy metabolism and in the biosynthesis of cellular molecules. A s..