Andrew Gibbons

An investigation into nicotinic receptor involvement in mood disorders uncovers novel depression candidate genes

Andrew Gibbons, Kate McPherson, Andrea Gogos, Brian Dean

Journal article  |  2021  |  JOURNAL OF AFFECTIVE DISORDERS

BACKGROUND: We have previously reported reduced expression of the cholinergic autoreceptor CHRM2 in Brodmann's Area (BA) 24 of the..

Cortical expression of the RAPGEF1 gene in schizophrenia: investigating regional differences and suicide

Andrea Gogos, Jeehae Sun, Madhara Udawela, Andrew Gibbons, Maarten van den Buuse, Elizabeth Scarr, Brian Dean

Journal article  |  2021  |  PSYCHIATRY RESEARCH

Rap guanine nucleotide exchange factor 1 (RAPGEF1) is involved in cell adhesion and neuronal migration. Previously we found lower ..

Bazedoxifene - a promising brain active SERM that crosses the blood brain barrier and enhances spatial memory

RA Hill, K Kouremenos, D Tull, A Maggi, A Schroeder, A Gibbons, J Kulkarni, S Sundram, X Du

Journal article  |  2020  |  PSYCHONEUROENDOCRINOLOGY

Over 20 years of accumulated evidence has shown that the major female sex hormone 17β-estradiol can enhance cognitive functioning...

Changes in Non-Coding RNA in Depression and Bipolar Disorder: Can They Be Used as Diagnostic or Theranostic Biomarkers?

Andrew Gibbons, Suresh Sundram, Brian Dean

Journal article  |  2020  |  NON-CODING RNA

The similarities between the depressive symptoms of Major Depressive Disorders (MDD) and Bipolar Disorders (BD) suggest these diso..

SMAD4 protein is decreased in the dorsolateral prefrontal and anterior cingulate cortices in schizophrenia

Andrew S Gibbons, Daniel Hoyer, Brian Dean

Journal article  |  2020  |  WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

OBJECTIVES: Signal transduction through the mothers against decapentaplegic (SMAD) is a family of signal transduction factors that..

The Impact of Removal of Ovarian Hormones on Cholinergic Muscarinic Receptors: Examining Prepulse Inhibition and Receptor Binding

Sarah S Ch'ng, Adam J Walker, Madeleine McCarthy, Thien-Kim Le, Natalie Thomas, Andrew Gibbons, Madhara Udawela, Snezana Kusljic, Brian Dean, Andrea Gogos

Journal article  |  2020  |  BRAIN SCIENCES

Ovarian hormones, such as estrogens and progesterone, are known to exert beneficial effects on cognition and some psychiatric diso..

Children's literature in China: Revisiting ideologies of childhood and agency

Marek Tesar, Zhen Phoebe Tong, Andrew Gibbons, Sonja Arndt, Adrienne Sansom

Journal article  |  2019  |  CONTEMPORARY ISSUES IN EARLY CHILDHOOD

In this article we consider historical and contemporary ideologies of childhood in China and critically examine notions of ‘child’..

Tumor necrosis factor receptor 2: A potential target for antidepressant drug development

N Seymour, A Gibbons, B Dean

Journal article  |  2019  |  Clinical and Experimental Neuroimmunology

A large body of work implicates cytokines and their related pathways in the pathophysiologies of mood disorders. Much of the data ..

Changes in levels of cortical metabotropic glutamate 2 receptors with gender and suicide but not psychiatric diagnoses

Brian Dean, Clare Duncan, Andrew Gibbons

Journal article  |  2019  |  JOURNAL OF AFFECTIVE DISORDERS

BACKGROUND: We previously reported that, compared to controls, there are lower levels of [3H]LY341495 binding to metabotropic 2/3 ..

Beta-actin does not show the characteristics of a reference protein in human cortex

Georgia M Parkin, Madhara Udawela, Andrew Gibbons, Brian Dean

Journal article  |  2019  |  ELECTROPHORESIS

Levels of a reference protein must be the same as a proportion of total protein in all tissues and, in the study of human diseases..