Prof. Karin Thursky is the director (CIA) of the NHMRC-CRE National Centre for Antimicrobial Stewardship (NCAS) (based at the University of Melbourne), which is taking a ‘one health’ approach to improving antimicrobial use across all human and animal health sectors; clinical director of the Guidance Group at the Royal Melbourne Hospital (RMH) at the Doherty; deputy head of Infectious Diseases at Peter MacCallum Cancer Hospital; and principal fellow in the Department of Medicine at the University of Melbourne and the Sir Peter MacCallum Department of Oncology. She was awarded an MD in 2007, with a thesis titled: "Development of an antibiotic computerised decision-support system for the ICU at RMH".
Prof. Thursky is nationally and internationally recognised as an expert in health services research, especially in antimicrobial stewardship (AMS). As the clinical leader and original developer of the Guidance software (developed at the RMH), she has assisted in the implementation of AMS in over 70 hospitals nationally and has directly contributed to increased workforce capacity for both clinical practice and research in AMS. She is a member of the AMS working party for Australian Commission on Quality and Safety in Healthcare (ACQSHC); and an expert advisor for the national program (AURA) responsible for developing national antimicrobial use and pathogen surveillance, and the Antimicrobial Resistance Strategic Technical Advisory Group for the Commonwealth Department of Health. She leads the development and implementation of the National Antimicrobial Prescribing Survey (NAPS), a program that is a key partner in the AURA system. She has considerable expertise in the development of national consensus guidelines. Her expertise in knowledge translation has led to several successful projects, including the development and implementation of a whole-of-hospital sepsis clinical program. She was the clinical lead for the Victorian ‘Think sepsis. Act fast.’ program. She is leading the implementation stream of the CRE the National Centre for Infections in Cancer (NCIC) (based at the Peter MacCallum Cancer Centre), and will focus on sepsis, neutropenic fever and stewardship models in the immunocompromised patient.
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Kas Thursky's selected work
There'S No Place Like Home: National Scale Up Of The Paediatric Low Risk Febrile Neutropen..
Epidemiology and risks for infection following cytoreductive surgery and hyperthermic intr..
Meeting The Challenges Of Invasive Fungal Infection: Antifungal Stewardship And Effective ..
Displaying the 12 most recent projects by Kas Thursky.
Displaying the 184 most recent scholarly works by Kas Thursky.
Evaluating the implementability of Antibiotic Surgical Prophylaxis guidelines.
Courtney Ierano, Darshini Ayton, Trisha Peel, Caroline Marshall, Karin Thursky
Journal article | 2020 | Infection, Disease & Health
BACKGROUND: Current Australian data highlight guideline noncompliant prescribing of antimicrobials for surgical prophylaxis. The s..
Epidemiology and risks for infection following cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy
OC Smibert, MA Slavin, B Teh, AG Heriot, J Penno, H Ismail, KA Thursky, LJ Worth
Journal article | 2019 | Supportive Care in Cancer
BACKGROUND: CRS-HIPEC is associated with improved cancer survival but an increased risk of infection. METHODS: Consecutive patient..
Antibiotic appropriateness and guideline adherence in hospitalized children: results of a nationwide study.
Brendan J McMullan, Lisa Hall, Rodney James, Mona Mostaghim, Cheryl A Jones, Pamela Konecny, Christopher C Blyth, Karin A Thursky
Journal article | 2019 | Journal of Antimicrobial Chemotherapy
BACKGROUND: Information on the nature and appropriateness of antibiotic prescribing for children in hospitals is important, but sc..
Appropriateness of Surgical Antimicrobial Prophylaxis Practices in Australia.
Courtney Ierano, Karin Thursky, Caroline Marshall, Sonia Koning, Rod James, Sandra Johnson, Nabeel Imam, Leon J Worth, Trisha Peel
Journal article | 2019 | JAMA Network Open
Importance: Surgical antimicrobial prophylaxis (SAP) is a common indication for antibiotic use in hospitals and is associated with..
Beta-Lactam and Sulfonamide Allergy Testing Should Be a Standard of Care in Immunocompromised Hosts
Jason A Trubiano, Monica A Slavin, Karin A Thursky, M Lindsay Grayson, Elizabeth J Phillips
Journal article | 2019 | The Journal of Allergy and Clinical Immunology: In Practice
Antibiotic allergies are reported in up to 1 in 4 immunocompromised hosts with significant impacts on antibiotic utilization and p..
FDG-PET/CT in managing infection in patients with hematological malignancy: clinician knowledge and experience in Australia
Abby P Douglas, Karin A Thursky, Leon J Worth, Simon James Harrison, Rod John Hicks, Monica A Slavin
Journal article | 2019 | Leukemia & Lymphoma
PET/CT is useful for investigation of neutropenic fever (NF) and potential invasive fungal infection (IFI) in those with hematolog..
How to start an antimicrobial stewardship programme in a hospital.
M Mendelson, AM Morris, K Thursky, C Pulcini
Journal article | 2019 | Clinical Microbiology and Infection
BACKGROUND: Antimicrobial stewardship (AMS) describes a coherent set of actions that ensure optimal use of antimicrobials to impro..
How do general practitioners access guidelines and utilise electronic medical records to make clinical decisions on antibiotic use? Results from an Australian qualitative study
Ruby Biezen, Cassandra Roberts, Kirsty Buising, Karin Thursky, Douglas Boyle, Phyllis Lau, Malcolm Clark, Jo-Anne Manski-Nankervis
Journal article | 2019 | BMJ Open
OBJECTIVE: This study aimed to explore how general practitioners (GPs) access and use both guidelines and electronic medical recor..
A simple score can identify kidney transplant recipients at high risk of severe infection over the following 2 years
Claire Dendle, Kevan R Polkinghorne, William R Mulley, Poh-Yi Gan, John Kanellis, Rhonda L Stuart, Karin Thursky, Stephen R Holdsworth
Journal article | 2019 | Transplant Infectious Disease
Access, knowledge and experience with fluorodeoxyglucose positron emission tomography/computed tomography in infection management: a survey of Australia and New Zealand infectious diseases physicians and microbiologists
Abby P Douglas, Karin A Thursky, Leon J Worth, Simon J Harrison, Rodney J Hicks, Monica A Slavin
Journal article | 2019 | Internal Medicine Journal
Impact of a hospital-wide sepsis pathway on improved quality of care and clinical outcomes in surgical patients at a comprehensive cancer centre
Alison Hiong, Karin A Thursky, Georgina Venn, Benjamin W Teh, Gabrielle M Haeusler, Megan Crane, Monica A Slavin, Leon J Worth
Journal article | 2019 | European Journal of Cancer Care
'It gave me information immediately on what I needed': co-design and simulation of a new clinical decision support tool for antibiotic prescribing in general practice.
Jo-Anne Manski-Nankervis, Ruby Biezen, Douglas Boyle, Sean Lo, Malcolm Clark, Karin Thursky, Kirsty Buising
Conference Proceedings | 2019 | AUSTRALIAN JOURNAL OF PRIMARY HEALTH
Developing core elements and checklist items for global hospital antimicrobial stewardship programmes: a consensus approach
C Pulcini, F Binda, AS Lamkang, A Trett, E Charani, DA Goff, S Harbarth, SL Hinrichsen, G Levy-Hara, M Mendelson, D Nathwani, R Gunturu, S Singh, A Srinivasan, V Thamlikitkul, K Thursky, E Vlieghe, H Wertheim, M Zeng, S Gandra, et al.
Journal article | 2019 | Clinical Microbiology and Infection
Influences on surgical antimicrobial prophylaxis decision making by surgical craft groups, anaesthetists, pharmacists and nurses in public and private hospitals.
Courtney Ierano, Karin Thursky, Trisha Peel, Arjun Rajkhowa, Caroline Marshall, Darshini Ayton
Journal article | 2019 | PLOS ONE
BACKGROUND: Surgical antimicrobial prophylaxis (SAP) is a leading indication for antibiotic use in the hospital setting, with demo..
Skin and soft tissue infections and current antimicrobial prescribing practices in Australian aged care residents
NJ Bennett, N Imam, RJ Ingram, RS James, KL Buising, AL Bull, CS Chen, KA Thursky, LJ Worth
Journal article | 2019 | Epidemiology and Infection
To determine the burden of skin and soft tissue infections (SSTI), the nature of antimicrobial prescribing and factors contributin..
1121. Epidemiology and Risks for Infection Following Cytoreductive Surgery and Hyperthermic Intra-Peritoneal Chemotherapy at an Australian Centre.
Olivia Smibert, Monica Slavin, Karin Thursky, Ben Teh, Janelle Penno, Hilmy Ismail, Leon Worth
Journal article | 2018 | Open Forum Infectious Diseases
AbstractBackgroundCytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is associated with improved can..
Description of the rationale and core domains of an antimicrobial stewardship in cancer specialist nursing role
Belinda Lambros, Karin Thursky, Monica Slavin, Jason Trubiano, Benjamin Teh, Gabrielle Haeusler, Leon Worth, Mei Krishnasamy
Conference Proceedings | 2018 | ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
Population wide assessment of antimicrobial use in dogs and cats using a novel data source - A cohort study using pet insurance data
Laura Yvonne Hardefeldt, Joshua Selinger, Mark Anthony Stevenson, James Rudkin Gilkerson, Helen Crabb, Helen Billman-Jacobe, Karin Thursky, Kirsten Erin Bailey, Magdoline Awad, Glenn Francis Browning
Journal article | 2018 | Veterinary Microbiology
Prevalence of infections and antimicrobial prescribing in Australian aged care facilities: Evaluation of modifiable and nonmodifiable determinants
Noleen Bennett, Nabeel Imam, Rodney James, Caroline Chen, Ann Bull, Karin Thursky, Kirsty Buising, Leon Worth
Journal article | 2018 | American Journal of Infection Control
The Combined Utility of Ex Vivo IFN-gamma Release Enzyme-Linked ImmunoSpot Assay and In Vivo Skin Testing in Patients with Antibiotic-Associated Severe Cutaneous Adverse Reactions
Jason A Trubiano, Kaija Strautins, Alec J Redwood, Rebecca Pavlos, Katherine C Konvinse, Ar Kar Aung, Monica A Slavin, Karin A Thursky, M Lindsay Grayson, Elizabeth J Phillips
Journal article | 2018 | The Journal of Allergy and Clinical Immunology: In Practice
Seroresponses and safety of 13-valent pneumococcal conjugate vaccination in kidney transplant recipients
Claire Dendle, Rhonda L Stuart, Kevan R Polkinghorne, Anne Balloch, John Kanellis, Johnathan Ling, Megan Kummrow, Chelsea Moore, Karin Thursky, Jim Buttery, Kim Mulholland, Poh-Yi Gan, Stephen Holdsworth, William R Mulley
Journal article | 2018 | Transplant Infectious Disease
Implementation of a whole of hospital sepsis clinical pathway in a cancer hospital: impact on sepsis management, outcomes and costs.
Karin Thursky, Senthil Lingaratnam, Jasveer Jayarajan, Gabrielle M Haeusler, Benjamin Teh, Michelle Tew, Georgina Venn, Alison Hiong, Christine Brown, Vivian Leung, Leon J Worth, Kim Dalziel, Monica A Slavin
Journal article | 2018 | BMJ Open Quality
Infection and sepsis are common problems in cancer management affecting up to 45% of patients and are associated with significant ..
Human resources estimates and funding for antibiotic stewardship teams are urgently needed
C Pulcini, CM Morel, E Tacconelli, B Beovic, K de With, H Goossens, S Harbarth, A Holmes, P Howard, AM Morris, D Nathwani, M Sharland, J Schouten, K Thursky, R Laxminarayan, M Mendelson
Journal article | 2017 | Clinical Microbiology and Infection
Predicting Risk of Infection in Patients with Newly Diagnosed Multiple Myeloma: Utility of Immune Profiling
Benjamin W Teh, Simon J Harrison, Cody Charles Allison, Monica A Slavin, Tim Spelman, Leon J Worth, Karin A Thursky, David Ritchie, Marc Pellegrini
Journal article | 2017 | Frontiers in Immunology
Impact of an Integrated Antibiotic Allergy Testing Program on Antimicrobial Stewardship: A Multicenter Evaluation
Jason A Trubiano, Karin A Thursky, Andrew J Stewardson, Karen Urbancic, Leon J Worth, Cheryl Jackson, Wendy Stevenson, Michael Sutherland, Monica A Slavin, M Lindsay Grayson, Elizabeth J Phillips
Journal article | 2017 | CLINICAL INFECTIOUS DISEASES
Risks factors and outcomes of Clostridium difficile infection in patients with cancer: a matched case-control study
Andrew IT Hebbard, Monica A Slavin, Caroline Reed, Jason A Trubiano, Benjamin W Teh, Gabrielle M Haeusler, Karin A Thursky, Leon J Worth
Journal article | 2017 | Supportive Care in Cancer
Toward Electronic Surveillance of Invasive Mold Diseases in Hematology-Oncology Patients: An Expert System Combining Natural Language Processing of Chest Computed Tomography Reports, Microbiology, and Antifungal Drug Data
Michelle R Ananda-Rajah, Christoph Bergmeir, Frangois Petitjean, Monica A Slavin, Karin A Thursky, Geoffrey Webb
Journal article | 2017 | JCO Clinical Cancer Informatics
Improving Antimicrobial Stewardship by Antibiotic Allergy Delabeling: Evaluation of Knowledge, Attitude, and Practices Throughout the Emerging Infections Network
Jason A Trubiano, Susan E Beekmann, Leon J Worth, Philip M Polgreen, Karin A Thursky, Monica A Slavin, M Lindsay Grayson, Elizabeth J Phillips
Journal article | 2016 | Open Forum Infectious Diseases
Risks and burden of viral respiratory tract infections in patients with multiple myeloma in the era of immunomodulatory drugs and bortezomib: experience at an Australian Cancer Hospital
Benjamin W Teh, Leon J Worth, Simon J Harrison, Karin A Thursky, Monica A Slavin
Journal article | 2015 | Supportive Care in Cancer
Measuring antimicrobial prescribing quality in Australian hospitals: development and evaluation of a national antimicrobial prescribing survey tool
Rodney James, Lydia Upjohn, Menino Cotta, Susan Luu, Caroline Marshall, Kirsty Buising, Karin Thursky
Journal article | 2015 | Journal of Antimicrobial Chemotherapy
Invasive infections due to filamentous fungi other than Aspergillus: epidemiology and determinants of mortality
M Slavin, S van Hal, TC Sorrell, A Lee, DJ Marriott, K Daveson, K Kennedy, K Hajkowicz, C Halliday, E Athan, N Bak, E Cheong, CH Heath, C Orla Morrissey, S Kidd, R Beresford, C Blyth, TM Korman, J Owen Robinson, W Meyer, et al.
Journal article | 2015 | Clinical Microbiology and Infection
Utility of bronchoalveolar lavage fluid galactomannan alone or in combination with PCR for the diagnosis of invasive aspergillosis in adult hematology patients: A systematic review and meta-analysis
Siow Chin Heng, Orla Morrissey, Sharon C-A Chen, Karin Thursky, Renee L Manser, Roger L Nation, David C-M Kong, Monica Slavin
Journal article | 2015 | Critical Reviews in Microbiology
Pneumocystis jirovecii pneumonia associated with gemcitabine chemotherapy: experience at an Australian center and recommendations for targeted prophylaxis
Senthil M Lingaratnam, Monica A Slavin, Karin A Thursky, Benjamin W Teh, Gabrielle M Haeusler, John F Seymour, Danny Rischin, Leon J Worth
Journal article | 2015 | Leukemia & Lymphoma
Survey of antifungal prophylaxis and fungal diagnostic tests employed in malignant haematology and haemopoietic stem cell transplantation (HSCT) in Australia and New Zealand
SJ van Hal, NM Gilroy, CO Morrissey, LJ Worth, J Szer, CS Tam, SC Chen, KA Thursky, MA Slavin
Journal article | 2014 | Internal Medicine Journal
Facilitating Surveillance of Pulmonary Invasive Mold Diseases in Patients with Haematological Malignancies by Screening Computed Tomography Reports Using Natural Language Processing
Michelle R Ananda-Rajah, David Martinez, Monica A Slavin, Lawrence Cavedon, Michael Dooley, Allen Cheng, Karin A Thursky
Journal article | 2014 | PLoS ONE
Clinical utility of Aspergillus galactomannan and PCR in bronchoalveolar lavage fluid for the diagnosis of invasive pulmonary aspergillosis in patients with haematological malignancies
Siow-Chin Heng, Sharon C-A Chen, C Orla Morrissey, Karin Thursky, Renee L Manser, Harini D De Silva, Catriona L Halliday, John F Seymour, Roger L Nation, David CM Kong, Monica A Slavin
Journal article | 2014 | Diagnostic Microbiology and Infectious Disease
Late-onset Pneumocystis jirovecii pneumonia post-fludarabine, cyclophosphamide and rituximab: implications for prophylaxis
Gabrielle M Haeusler, Monica A Slavin, John F Seymour, Senthil Lingaratnam, Benjamin W Teh, Constantine S Tam, Karin A Thursky, Leon J Worth
Journal article | 2013 | European Journal of Haematology
Pharmacoeconomic evaluation of fluconazole, posaconazole and voriconazole for antifungal prophylaxis in patients with acute myeloid leukaemia undergoing first consolidation chemotherapy
Siow-Chin Heng, Monica A Slavin, Daoud Al-Badriyeh, Sue Kirsa, John F Seymour, Andrew Grigg, Karin Thursky, Ashish Bajel, Roger L Nation, David CM Kong
Journal article | 2013 | Journal of Antimicrobial Chemotherapy
Impact of fluorine-18 fluorodeoxyglucose positron emission tomography on diagnosis and antimicrobial utilization in patients with high-risk febrile neutropenia
Kwee Choy Koh, Monica A Slavin, Karin A Thursky, Eddie Lau, Rodney J Hicks, Elizabeth Drummond, Peng Shyan Wong, Leon J Worth
Journal article | 2012 | Leukemia and Lymphoma
Use of FDG PET/CT for investigation of febrile neutropenia: evaluation in high-risk cancer patients
Stephen D Guy, Adrian R Tramontana, Leon J Worth, Eddie Lau, Rodney J Hicks, John F Seymour, Karin A Thursky, Monica A Slavin
Journal article | 2012 | European Journal of Nuclear Medicine and Molecular Imaging
Comparative clinical effectiveness of prophylactic voriconazole/posaconazole to fluconazole/itraconazole in patients with acute myeloid leukemia/myelodysplastic syndrome undergoing cytotoxic chemotherapy over a 12-year period
Michelle R Ananda-Rajah, Andrew Grigg, Maria T Downey, Ashish Bajel, Tim Spelman, Allen Cheng, Karin T Thursky, Janette Vincent, Monica A Slavin
Journal article | 2012 | Haematologica
Current hepatitis B screening practices and clinical experience of reactivation in patients undergoing chemotherapy for solid tumors: a nationwide survey of medical oncologists.
Fiona L Day, Emma Link, Karin Thursky, Danny Rischin
Journal article | 2011 | Journal of Oncology Practice
PURPOSE: Universal screening for chronic hepatitis B virus (HBV) before chemotherapy has been recommended by the Centers for Disea..
An Australian survey of clinical practices in management of neutropenic fever in adult cancer patients 2009
S Lingaratnam, MA Slavin, L Mileshkin, B Solomon, K Burbury, JF Seymour, R Sharma, B Koczwara, SW Kirsa, ID Davis, M Prince, J Szer, C Underhill, O Morrissey, KA Thursky
Journal article | 2011 | Internal Medicine Journal
A cost analysis of febrile neutropenia management in Australia: ambulatory v. in-hospital treatment
Senthil Lingaratnam, Leon J Worth, Monica A Slavin, Craig A Bennett, Suzanne W Kirsa, John F Seymour, Andrew Dalton, Bogda Koczwara, H Miles Prince, Mary O'Reilly, Linda Mileshkin, Jeff Szer, Karin A Thursky
Journal article | 2011 | Australian Health Review
Introduction to the Australian consensus guidelines for the management of neutropenic fever in adult cancer patients, 2010/2011
S Lingaratnam, MA Slavin, B Koczwara, JF Seymour, J Szer, C Underhill, M Prince, L Mileshkin, M O'Reilly, SW Kirsa, CA Bennett, ID Davis, O Morrissey, KA Thursky
Journal article | 2011 | Internal Medicine Journal
Oseltamivir Resistance in Adult Oncology and Hematology Patients Infected with Pandemic (H1N1) 2009 Virus, Australia
Adrian R Tramontana, Biju George, Aeron C Hurt, Joseph S Doyle, Katherine Langan, Alistair B Reid, Janet M Harper, Karin Thursky, Leon J Worth, Dominic E Dwyer, C Orla Morrissey, Paul DR Johnson, Kirsty L Buising, Simon James Harrison, John F Seymour, Patricia E Ferguson, Bin Wang, Justin T Denholm, Allen C Cheng, Monica Slavin
Journal article | 2010 | Emerging Infectious Diseases
Pharmacoeconomic evaluation of voriconazole versus posaconazole for antifungal prophylaxis in acute myeloid leukaemia
Daoud Al-Badriyeh, Monica Slavin, Danny Liew, Karin Thursky, Maria Downey, Andrew Grigg, Ashish Bajel, Kay Stewart, David CM Kong
Journal article | 2010 | Journal of Antimicrobial Chemotherapy
A global study of pathogens and host risk factors associated with infectious gastrointestinal disease in returned international travellers
Ashwin Swaminathan, Joseph Torresi, Patricia Schlagenhauf, Karin Thursky, Annelies Wilder-Smith, Bradley A Connor, Eli Schwartz, Frank vonSonnenberg, Jay Keystone, Daniel P O'Brien
Journal article | 2009 | Journal of Infection
Electronic antibiotic stewardship - reduced consumption of broad-spectrum antibiotics using a computerized antimicrobial approval system in a hospital setting
KL Buising, KA Thursky, MB Robertson, JF Black, AC Street, MJ Richards, GV Brown
Journal article | 2008 | Journal of Antimicrobial Chemotherapy
Improving antibiotic prescribing for adults with community acquired pneumonia: Does a computerised decision support system achieve more than academic detailing alone? a time series analysis
Kirsty L Buising, Karin A Thursky, James F Black, Lachlan MacGregor, Alan C Street, Marcus P Kennedy, Graham V Brown
Journal article | 2008 | BMC Medical Informatics and Decision Making
Virulence determinants in vancomycin-resistant Enterococcus faecium vanB: clonal distribution, prevalence and significance of esp and hyl in Australian patients with haematological disorders
LJ Worth, MA Slavin, V Vankerckhoven, H Goossens, EA Grabsch, KA Thursky
Journal article | 2008 | Journal of Hospital Infection
Reduction of broad-spectrum antibiotic use with computerized decision support in an intensive care unit
Karin A Thursky, Kirsty L Buising, Narin Bak, Lachlan MacGregor, Alan C Street, C Raina MacIntyre, Jeffrey J Presneill, John F Cade, Graham V Brown
Journal article | 2006 | International Journal for Quality in Health Care
Guidelines for the use of antifungal agents in the treatment of invasive Candida and mould infections (vol 34, pg 192, 2004)
MA Slavin, J Szer, AP Grigg, AW Roberts, JF Seymour, J Sasadeusz, K Thursky, SC Chen, CO Morrissey, CH Heath, HM Prince, T Sorrell
Journal article | 2004 | INTERNAL MEDICINE JOURNAL
Displaying the 4 most recent news articles by Kas Thursky.
Honours, Awards and Fellowships
Winner: Faculty of Medicine, Dentistry and Health Science Staff Excellence Award - Engagement
Fellow of the Australian Academy of Health and Medical Sciences
Dame Kate Campbell Fellowship
Winner: Australian Council on Health Care Standards Award
Highly commended: Australian Council on Health Care Standards Award
Highly commended: Melbourne Health Excellence Award
Highly commended: Victorian Premier's Health Care Award
Winner: Melbourne Health Excellence Award
Winner: Peter Mac Excellence Awards
Winner: Victorian Premier's Health Care Award
Winner: Quality and Safety Prize, Australian Scientific Meeting, RACP
FRACP - Fellow of the Royal Australasian College of Physicians
Director, Nat Centre For Antimicrobial Stewardship
Medicine - Royal Melbourne Hospital
The Sir Peter Maccallum Department Of Oncology
Fellow Of The Australian Academy Of Health And Medical Sciences
Australian Academy of Health and Medical Sciences
Fellow Of The Royal Australasian College Of Physicians
Royal Australasian College of Physicians
Doctor of Medicine
Bachelor of Medicine and Surgery
Bachelor of Science