Mehrdad Nikfarjam

DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

Vanessa Lakis, Rita T Lawlor, Felicity Newell, Ann-Marie Patch, Andrea Mafficini, Anguraj Sadanandam, Lambros T Koufariotis, Rebecca L Johnston, Conrad Leonard, Scott Wood, Borislav Rusev, Vincenzo Corbo, Claudio Luchini, Sara Cingarlini, Luca Landoni, Roberto Salvia, Michele Milella, David Chang, Peter Bailey, Nigel B Jamieson, et al.

Journal article  |  2021  |  COMMUNICATIONS BIOLOGY

Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and ..

Investigating real-world treatment sequencing outcomes in advanced pancreatic cancer: A purple translational registry analysis.

Jordan Santucci, Belinda Lee, Shehara Ramyalini Mendis, Benjamin N Thomson, Michael Michael, Julia Shapiro, Rachel Wong, Kate Clarke, Sharon Tracy Pattison, Matthew E Burge, Robert Richard Zielinski, Mehrdad Nikfarjam, Sumitra Ananda, Lara Rachel Lipton, Peter Gibbs

Conference Proceedings  |  2021  |  JOURNAL OF CLINICAL ONCOLOGY

386 Background: Current standard combination first line palliative chemotherapy regimens in advanced pancreatic ductal adenocarci..

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Stephan B Dreyer, Rosie Upstill-Goddard, Viola Paulus-Hock, Clara Paris, Eirini-Maria Lampraki, Eloise Dray, Bryan Serrels, Giuseppina Caligiuri, Selma Rebus, Dennis Plenker, Zachary Galluzzo, Holly Brunton, Richard Cunningham, Mathias Tesson, Craig Nourse, Ulla-Maja Bailey, Marc Jones, Kim Moran-Jones, Derek W Wright, Fraser Duthie, et al.

Journal article  |  2021  |  GASTROENTEROLOGY

BACKGROUND & AIMS: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set ..

Outcomes of endoscopic ultrasound as a one-off pancreatic cancer screening tool for 122 high- and moderate-risk patients

Marios Efthymiou, Sujievvan Chandran, Leonardo Zorron Cheng Tao Pu, Allison Collins, Anton Rajadurai, Mehrdad Nikfarjam, Rhys Vaughan

Journal article  |  2020  |  JGH OPEN

Background and Aim Pancreatic cancer (PC) carries a poor prognosis and is often detected at later stages. Screening programs for m..

PanCO: Updated Results of an Open-Label, Single-Arm Pilot Study of OncoSil P-32 Microparticles in Combination with Standard-of-Care (SoC) Gemcitabine Nab-Paclitaxel or FOLFIRINOX Chemotherapy in Unresectable Locally Advanced Pancreatic Cancer (uLAPC)

Paul Ross, Alain Hendlisz, Thankamma Ajithkumar, Chinenye Iwuji, Marion Harris, Daniel Croagh, Morteza Aghmesheh, Adnan Nagrial, Nam Nguyen, Mehrdad Nikfarjam, Nicole Wilson, Daniel Kenny, David Turner, Harpreet S Wasan

Journal article  |  2020  |  Pancreatology

Advanced Endoscopic Techniques

M Efthymiou, S Chandran, L Zorron Cheng Tao Pu, A Collins, A Rajadurai, M Nikfarjam, R Vaughan

Conference Proceedings  |  2020  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Cannabinoids Inhibited Pancreatic Cancer via P-21 Activated Kinase 1 Mediated Pathway

Yang Yang, Huynh Nhi, Chelsea Dumesny, Kai Wang, Hong He, Mehrdad Nikfarjam

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The anti-cancer effects of cannabinoids including CBD (Cannabidiol) and THC ((-)-trans-∆9-tetrahydrocannabinol) have been reported..

Postoperative complications and hospital costs following small bowel resection surgery

Dong-Kyu Lee, Ashlee Frye, Maleck Louis, Anoop Ninan Koshy, Shervin Tosif, Matthew Yii, Ronald Ma, Mehrdad Nikfarjam, Marcos Vinicius Perini, Rinaldo Bellomo, Laurence Weinberg

Journal article  |  2020  |  PLOS ONE

BACKGROUND: Postoperative complications after major gastrointestinal surgery are a major contributor to hospital costs. Thus, redu..

PanCO: Updated results of an open-label, single-arm pilot study of OncoSil P-32 microparticles in unresectable locally advanced pancreatic adenocarcinoma (LAPC) with gemcitabine plus nab-paclitaxel or FOLFIRINOX chemotherapy

P Ross, A Hendlisz, T Ajithkumar, C Iwuji, M Harris, D Croagh, M Aghmesheh, A Nagrial, N Nguyen, M Nikfarjam, N Wilson, D Kenny, D Turner, H Wasan

Conference Proceedings  |  2020  |  ANNALS OF ONCOLOGY

HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

Holly Brunton, Giuseppina Caligiuri, Richard Cunningham, Rosie Upstill-Goddard, Ulla-Maja Bailey, Ian M Garner, Craig Nourse, Stephan Dreyer, Marc Jones, Kim Moran-Jones, Derek W Wright, Viola Paulus-Hock, Colin Nixon, Gemma Thomson, Nigel B Jamieson, Grant A McGregor, Lisa Evers, Colin J McKay, Aditi Gulati, Rachel Brough, et al.

Journal article  |  2020  |  CELL REPORTS

Pancreatic ductal adenocarcinoma (PDAC) can be divided into transcriptomic subtypes with two broad lineages referred to as classic..