John Karas

Structure of micelle bound cationic peptides by NMR spectroscopy using a lanthanide shift reagent

James D Swarbrick, John A Karas, Jian Li, Tony Velkov

Journal article  |  2020  |  Chemical Communications

[Tm(DPA)3]3- was used to generate multiple, paramagnetic nuclear Overhauser effect NMR spectra of cationic peptides when weakly bo..

1,3-Dichloroacetone: A Robust Reagent for Preparing Bicyclic Peptides

Qingqing Lin, Denham Hopper, Haoyue Zhang, Jordan Sfyris Qoon, Zihan Shen, John A Karas, Richard A Hughes, Susan E Northfield

Journal article  |  2020  |  ACS Omega

The chemical synthesis of cyclic peptides is a well-established area of research. This has been further expanded by development of..

Total Chemical Synthesis of a Nonfibrillating Human Glycoinsulin

Mohammed Akhter Hossain, Rio Okamoto, John A Karas, Praveen Praveen, Mengjie Liu, Briony E Forbes, John D Wade, Yasuhiro Kajihara

Journal article  |  2020  |  Journal of the American Chemical Society

Glycosylation is an accepted strategy to improve the therapeutic value of peptide and protein drugs. Insulin and its analogues are..

Synthesis and structure-activity relationships of teixobactin

John A Karas, Fan Chen, Elena K Schneider-Futschik, Zhisen Kang, Maytham Hussein, James Swarbrick, Daniel Hoyer, Andrew M Giltrap, Richard J Payne, Jian Li, Tony Velkov

Journal article  |  2019  |  Annals of the New York Academy of Sciences

The impact of backbone N-methylation on the structure-activity relationship of Leu(10)-teixobactin

Tony Velkov, James D Swarbrick, Maytham H Hussein, Elena K Schneider-Futschik, Daniel Hoyer, Jian Li, John A Karas

Journal article  |  2019  |  Journal of Peptide Science

Rapid Photolysis-Mediated Folding of Disulfide-Rich Peptides

Nitin A Patil, John A Karas, John D Wade, Mohammed Akhter Hossain, Julien Tailhades

Journal article  |  2019  |  Chemistry – A European Journal

Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide-PNA Conjugates

Nitin A Patil, John A Karas, Bradley J Turner, Fazel Shabanpoor

Journal article  |  2019  |  Bioconjugate Chemistry

Nuclear Magnetic Resonance Study of the Peptide FRANCESSEPAROVIC

JA Karas, DW Keizer, MA Sani

Journal article  |  2019  |  Australian Journal of Chemistry

As an eminent ambassador of STEM and renowned NMR spectroscopist, Frances Separovic is an internationally famous name, but could i..

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules

Elena K Schneider-Futschik, Olivia KA Paulin, Daniel Hoyer, Kade D Roberts, James Ziogas, Mark A Baker, John Karas, Jian Li, Tony Velkov

Journal article  |  2018  |  ACS Infectious Diseases

The Assembly of Fluorescently Labeled Peptide-Oligonucleotide Conjugates via Orthogonal Ligation Strategies

John Karas, Bradley J Turner, Fazel Shabanpoor

Book Chapter  |  2018  |  Methods in Molecular Biology

Rhenium and Technetium-oxo Complexes with Thioamide Derivatives of Pyridylhydrazine Bifunctional Chelators Conjugated to the Tumour Targeting Peptides Octreotate and Cyclic-RGDfK

Andrea J North, John A Karas, Michelle T Ma, Philip J Blower, Uwe Ackermann, Jonathan M White, Paul S Donnelly

Journal article  |  2017  |  Inorganic Chemistry

The efficient synthesis and purification of amyloid-beta(1-42) using an oligoethylene glycol-containing photocleavable lysine tag

John A Karas, Asif Noor, Christine Schieber, Timothy U Connell, Frances Separovic, Paul S Donnelly

Journal article  |  2017  |  Chemical Communications

Chemical Synthesis and Characterization of an Equinatoxin II(1-85) Analogue

John A Karas, Marc-Antoine Sani, Frances Separovic

Journal article  |  2017  |  Molecules

A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides

Nitin A Patil, Julien Tailhades, John A Karas, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  Angewandte Chemie International Edition

Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability

John A Karas, Nitin A Patil, Julien Tailhades, Marc-Antoine Sani, Denis B Scanlon, Briony E Forbes, James Gardiner, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  Angewandte Chemie International Edition

An enzyme-responsive controlled release system based on a dual-functional peptide

X Li, S Burger, AJ O'Connor, L Ong, JA Karas, SL Gras

Journal article  |  2016  |  Chemical Communications

2-Nitroveratryl as a Photocleavable Thiol-Protecting Group for Directed Disulfide Bond Formation in the Chemical Synthesis of Insulin

John A Karas, Denis B Scanlon, Briony E Forbes, Irina Vetter, Richard J Lewis, James Gardiner, Frances Separovic, John D Wade, Mohammed A Hossain

Journal article  |  2014  |  Chemistry - A European Journal

One-step radiosynthesis of 4-nitrophenyl 2-[F-18]fluoropropionate ([F-18]NFP); improved preparation of radiolabeled peptides for PET imaging

Mohammad B Haskali, Peter D Roselt, John A Karas, Wayne Noonan, Christian W Wichmann, Andrew Katsifis, Rodney J Hicks, Craig A Hutton

Journal article  |  2013  |  Journal of Labelled Compounds & Radiopharmaceuticals

Chemical Synthesis of a Fluorescent IGF-II Analogue

Jade M Cottam, Denis B Scanlon, John A Karas, Antonio N Calabrese, Tara L Pukala, Briony E Forbes, John C Wallace, Andrew D Abell

Journal article  |  2013  |  International Journal of Peptide Research and Therapeutics

Total chemical synthesis of a heterodimeric interchain bis-lactam-linked Peptide: application to an analogue of human insulin-like Peptide 3.

John Karas, Fazel Shabanpoor, Mohammed Akhter Hossain, James Gardiner, Frances Separovic, John D Wade, Denis B Scanlon

Journal article  |  2013  |  International Journal of Peptides

Nonreducible cystine isosteres represent important peptide design elements in that they can maintain a near-native tertiary confor..

Synthetic dityrosine-linked beta-amyloid dimers form stable, soluble, neurotoxic oligomers

W Mei Kok, Jade M Cottam, Giuseppe D Ciccotosto, Luke A Miles, John A Karas, Denis B Scanlon, Blaine R Roberts, Michael W Parker, Roberto Cappai, Kevin J Barnham, Craig A Hutton

Journal article  |  2013  |  Chemical Science

Modulation of Conotoxin Structure and Function Is Achieved through a Multienzyme Complex in the Venom Glands of Cone Snails

Helena Safavi-Hemami, Dhana G Gorasia, Andrew M Steiner, Nicholas A Williamson, John A Karas, Joanna Gajewiak, Baldomero M Olivera, Grzegorz Bulaj, Anthony W Purcell

Journal article  |  2012  |  Journal of Biological Chemistry

A Cyclic Peptide Inhibitor of ApoC-II Peptide Fibril Formation: Mechanistic Insight from NMR and Molecular Dynamics Analysis

Michael DW Griffin, Levi Yeung, Andrew Hung, Nevena Todorova, Yee-Foong Mok, John A Karas, Paul R Gooley, Irene Yarovsky, Geoffrey J Howlett

Journal article  |  2012  |  Journal of Molecular Biology

Microwave Synthesis of Prion Protein Fragments up to 111 Amino Acids in Length Generates Biologically Active Peptides

John A Karas, Martin Boland, Cathryn Haigh, Vanessa Johanssen, Andrew Hill, Kevin Barnham, Steven Collins, Denis Scanlon

Journal article  |  2012  |  International Journal of Peptide Research and Therapeutics

Misfolded conformers of the prion protein are aetiologically implicated in neurodegenerative conditions termed prion diseases (als..

Gallium-68 Complex of a Macrobicyclic Cage Amine Chelator Tethered to Two Integrin-Targeting Peptides for Diagnostic Tumor Imaging

Michelle T Ma, Oliver C Neels, Delphine Denoyer, Peter Roselt, John A Karas, Denis B Scanlon, Jonathan M White, Rodney J Hicks, Paul S Donnelly

Journal article  |  2011  |  Bioconjugate Chemistry

Total Synthesis of the Antifungal Depsipeptide Petriellin A

Marianne M Sleebs, Denis Scanlon, John Karas, Rani Maharani, Andrew B Hughes

Journal article  |  2011  |  The Journal of Organic Chemistry

We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confir..

Macrobicyclic Cage Amine Ligands for Copper Radiopharmaceuticals: A Single Bivalent Cage Amine Containing Two Lys(3)-bombesin Targeting Peptides

Michelle T Ma, Margaret S Cooper, Rowena L Paul, Karen P Shaw, John A Karas, Denis Scanlon, Jonathan M White, Philip J Blower, Paul S Donnelly

Journal article  |  2011  |  Inorganic Chemistry

Synthesis of Peptide Sequences Derived from Fibril-Forming Proteins

Denis B Scanlon, John A Karas

Book Chapter  |  2011  |  Methods in Molecular Biology

Embryonic Toxin Expression in the Cone Snail Conus victoriae PRIMED TO KILL OR DIVERGENT FUNCTION?

Helena Safavi-Hemami, William A Siero, Zhihe Kuang, Nicholas A Williamson, John A Karas, Louise R Page, David MacMillan, Brid Callaghan, Shiva Nag Kompella, David J Adams, Raymond S Norton, Anthony W Purcell

Journal article  |  2011  |  Journal of Biological Chemistry

Predatory marine cone snails (genus Conus) utilize complex venoms mainly composed of small peptide toxins that target voltage- and..

Functional and Structural Diversification of the Anguimorpha Lizard Venom System

Bryan G Fry, Kelly Winter, Janette A Norman, Kim Roelants, Rob JA Nabuurs, Matthias JP van Osch, Wouter M Teeuwisse, Louise van der Weerd, Judith E Mcnaughtan, Hang Fai Kwok, Holger Scheib, Laura Greisman, Elazar Kochva, Laurence J Miller, Fan Gao, John Karas, Denis Scanlon, Feng Lin, Sanjaya Kuruppu, Chris Shaw, et al.

Journal article  |  2010  |  Molecular and Cellular Proteomics

Versatile New Bis(thiosemicarbazone) Bifunctional Chelators: Synthesis, Conjugation to Bombesin(7-14)-NH2, and Copper-64 Radiolabeling

Brett M Paterson, John A Karas, Denis B Scanlon, Jonathan M White, Paul S Donnelly

Journal article  |  2010  |  Inorganic Chemistry

Novel Venom Proteins Produced by Differential Domain-Expression Strategies in Beaded Lizards and Gila Monsters (genus Heloderma)

Bryan G Fry, Kim Roelants, Kelly Winter, Wayne C Hodgson, Laura Griesman, Hang Fai Kwok, Denis Scanlon, John Karas, Chris Shaw, Lily Wong, Janette A Norman

Journal article  |  2010  |  Molecular Biology and Evolution

Effects of mutation on the amyloidogenic propensity of apolipoprotein C-II60-70 peptide

Nevena Todorova, Andrew Hung, Simon M Maaser, Michael DW Griffin, John Karas, Geoffrey J Howlett, Irene Yarovsky

Journal article  |  2010  |  Physical Chemistry Chemical Physics

Mass Spectral Identification of Vc1.1 and Differential Distribution of Conopeptides in the Venom Duct of Conus victoriae. Effect of Post-Translational Modifications and Disulfide Isomerisation on Bioactivity

A Townsend, BG Livett, J-P Bingham, H-T Truong, JA Karas, P O'Donnell, NA Williamson, AW Purcell, D Scanlon

Journal article  |  2009  |  International Journal of Peptide Research and Therapeutics

Aromatic residues in the C-terminal helix of human apoC-I mediate phospholipid interactions and particle morphology

Patrick F James, Con Dogovski, Renwick CJ Dobson, Michael F Bailey, Kenneth N Goldie, John A Karas, Denis B Scanlon, Richard AJ O'Hair, Matthew A Perugini

Journal article  |  2009  |  Journal of Lipid Research

A central role for venom in predation by Varanus komodoensis (Komodo Dragon) and the extinct giant Varanus (Megalania) priscus

Bryan G Fry, Stephen Wroe, Wouter Teeuwisse, Matthias JP van Osch, Karen Moreno, Janette Ingle, Colin McHenry, Toni Ferrara, Phillip Clausen, Holger Scheib, Kelly L Winter, Laura Greisman, Kim Roelants, Louise van der Weerd, Christofer J Clemente, Eleni Giannakis, Wayne C Hodgson, Sonja Luz, Paolo Martelli, Karthiyani Krishnasamy, et al.

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

Rapid Optimization of a Peptide Inhibitor of Malaria Parasite Invasion by Comprehensive N-Methyl Scanning

Karen S Harris, Joanne L Casey, Andrew M Coley, John A Karas, Jennifer K Sabo, Yen Yee Tan, Olan Dolezal, Raymond S Norton, Andrew B Hughes, Denis Scanlon, Michael Foley

Journal article  |  2009  |  Journal of Biological Chemistry

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide

W Mei Kok, Denis B Scanlon, John A Karas, Luke A Miles, Deborah J Tew, Michael W Parker, Kevin J Barnham, Craig A Hutton

Journal article  |  2009  |  Chemical Communications

A new bifunctional chelator for copper radiopharmaceuticals: a cage amine ligand with a carboxylate functional group for conjugation to peptides

Michelle T Ma, John A Karas, Jonathan M White, Denis Scanlon, Paul S Donnelly

Journal article  |  2009  |  Chemical Communications

Comprehensive N-Methyl Scanning of a Potent Peptide Inhibitor of Malaria Invasion into Erythrocytes Leads to Pharmacokinetic Optimization of the Molecule

Denis Scanlon, Karen S Harris, Andrew M Coley, John A Karas, Joanne L Casey, Andrew B Hughes, Michael Foley

Conference Proceedings  |  2008  |  International Journal of Peptide Research and Therapeutics

Siah up-regulates the Hif-1alpha hypoxic response pathway: Siah binding peptides coupled to CPPs inhibit Siah activity and demonstrate proof of concept that Siah is a viable anti-tumor drug target

Denis Scanlo, Colin House, John Karas, Andreas Moeller, Christina Wong, Mira Liu, Ze'ev Ronai, David Bowtell

Conference Proceedings  |  2008  |  JOURNAL OF PEPTIDE SCIENCE