David Bowtell

Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival.

Katharine K Brieger, Siri Peterson, Alice W Lee, Bhramar Mukherjee, Kelly M Bakulski, Aliya Alimujiang, Hoda Anton-Culver, Michael S Anglesio, Elisa V Bandera, Andrew Berchuck, David DL Bowtell, Georgia Chenevix-Trench, Kathleen R Cho, Daniel W Cramer, Anna DeFazio, Jennifer A Doherty, Renée T Fortner, Dale W Garsed, Simon A Gayther, Aleksandra Gentry-Maharaj, et al.

Journal article  |  2020  |  Gynecologic Oncology

PURPOSE: Prior studies of menopausal hormone therapy (MHT) and ovarian cancer survival have been limited by lack of hormone regime..

Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium

Filipe Correia Martins, Dominique-Laurent Couturier, Anna Paterson, Anthony N Karnezis, Chow Christine, Tayyebeh M Nazeran, Adekunle Odunsi, Aleksandra Gentry-Maharaj, Aleksandra Vrvilo, Alexander Hein, Aline Talhouk, Ana Osorio, Andreas D Hartkopf, Angela Brooks-Wilson, Anna DeFazio, Anna Fischer, Arndt Hartmann, Brenda Y Hernandez, Bryan M McCauley, Chloe Karpinskyj, et al.

Journal article  |  2020  |  British Journal of Cancer

Development and validation of the gene-expression Predictor of high-grade-serous Ovarian carcinoma molecular subTYPE (PrOTYPE).

Aline Talhouk, Joshy George, Chen Wang, Timothy Budden, Tuan Zea Tan, Derek S Chiu, Stefan Kommoss, Huei San Leong, Stephanie Chen, Maria P Intermaggio, Blake Gilks, Tayyebeh Mehrane Nazeran, Mila Volchek, Wafaa Elatre, Rex C Bentley, Janine Senz, Amy Lum, Veronica Chow, Hanwei Sudderuddin, Robertson Mackenzie, et al.

Journal article  |  2020  |  Clinical Cancer Research

PURPOSE: Gene-expression-based molecular subtypes of high-grade serous tubo-ovarian cancer (HGSOC), demonstrated across multiple s..

Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer.

Honglin Song, Ed M Dicks, Jonathan Tyrer, Maria Intermaggio, Georgia Chenevix-Trench, David D Bowtell, Nadia Traficante, Aocs Group, James Brenton, Teodora Goranova, Karen Hosking, Anna Piskorz, Elke van Oudenhove, Jen Doherty, Holly R Harris, Mary Anne Rossing, Matthias Duerst, Thilo Dork, Natalia V Bogdanova, Francesmary Modugno, et al.

Journal article  |  2020  |  Journal of Medical Genetics

PURPOSE: The known epithelial ovarian cancer (EOC) susceptibility genes account for less than 50% of the heritable risk of ovarian..

Prognostic gene expression signature for high-grade serous ovarian cancer.

J Millstein, T Budden, EL Goode, MS Anglesio, A Talhouk, MP Intermaggio, HS Leong, S Chen, W Elatre, B Gilks, T Nazeran, M Volchek, RC Bentley, C Wang, DS Chiu, S Kommoss, SCY Leung, J Senz, A Lum, V Chow, et al.

Journal article  |  2020  |  Annals of Oncology

BACKGROUND: Median overall survival (OS) for women with high-grade serous ovarian cancer (HGSOC) is ∼4 years, yet survival varies ..

ABCC4/MRP4 contributes to the aggressiveness of Myc-associated epithelial ovarian cancer

Moonsun Jung, Jixuan Gao, Leanna Cheung, Angelika Bongers, Klaartje Somers, Molly Clifton, Emma E Ramsay, Amanda J Russell, Emanuele Valli, Andrew J Gifford, Joshy George, Catherine J Kennedy, Matthew J Wakefield, Monique Topp, Gwo-Yaw Ho, Clare L Scott, David D Bowtell, Anna deFazio, Murray D Norris, Michelle Haber, et al.

Journal article  |  2020  |  International Journal of Cancer

Germline whole exome sequencing of a family with appendiceal mucinous tumours presenting with pseudomyxoma peritonei

Mei Sim Lung, Catherine A Mitchell, Maria A Doyle, Andrew C Lynch, Kylie L Gorringe, David DL Bowtell, Ian G Campbell, Alison H Trainer

Journal article  |  2020  |  BMC Cancer

BACKGROUND: Familial cases of appendiceal mucinous tumours (AMTs) are extremely rare and the underlying genetic aetiology uncertai..

Therapeutic options for mucinous ovarian carcinoma

Kylie L Gorringe, Dane Cheasley, Matthew J Wakefield, Georgina L Ryland, Prue E Allan, Kathryn Alsop, Kaushalya C Amarasinghe, Sumitra Ananda, David DL Bowtell, Michael Christie, Yoke-Eng Chiew, Michael Churchman, Anna DeFazio, Sian Fereday, C Blake Gilks, Charlie Gourley, Alison M Hadley, Joy Hendley, Sally M Hunter, Scott H Kaufmann, et al.

Journal article  |  2020  |  Gynecologic Oncology

OBJECTIVE: Mucinous ovarian carcinoma (MOC) is an uncommon ovarian cancer histotype that responds poorly to conventional chemother..

Ovarian and breast cancer risks associated with pathogenic variants in RAD51C and RAD51D.

Xin Yang, Honglin Song, Goska Leslie, Christoph Engel, Eric Hahnen, Bernd Auber, Judit Horváth, Karin Kast, Dieter Niederacher, Clare Turnbull, Richard Houlston, Helen Hanson, Chey Loveday, Jill S Dolinsky, Holly LaDuca, Susan J Ramus, Usha Menon, Adam N Rosenthal, Ian Jacobs, Simon A Gayther, et al.

Journal article  |  2020  |  JNCI: Journal of the National Cancer Institute

BACKGROUND: The purpose of this study was to estimate precise age-specific tubo-ovarian carcinoma (TOC) and breast cancer (BC) ris..

The evolutionary history of 2,658 cancers

Moritz Gerstung, Clemency Jolly, Ignaty Leshchiner, Stefan C Dentro, Santiago Gonzalez, Daniel Rosebrock, Thomas J Mitchell, Yulia Rubanova, Pavana Anur, Kaixian Yu, Maxime Tarabichi, Amit Deshwar, Jeff Wintersinger, Kortine Kleinheinz, Ignacio Vazquez-Garcia, Kerstin Haase, Lara Jerman, Subhajit Sengupta, Geoff Macintyre, Salem Malikic, et al.

Journal article  |  2020  |  Nature

Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this proce..

Pan-cancer analysis of whole genomes

Peter J Campbell, Gad Getz, Jan O Korbel, Joshua M Stuart, Jennifer L Jennings, Lincoln D Stein, Marc D Perry, Hardeep K Nahal-Bose, BF Francis Ouellette, Constance H Li, Esther Rheinbay, G Petur Nielsen, Dennis C Sgroi, Chin-Lee Wu, William C Faquin, Vikram Deshpande, Paul C Boutros, Alexander J Lazar, Katherine A Hoadley, David N Louis, et al.

Journal article  |  2020  |  Nature

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this v..

Patterns of somatic structural variation in human cancer genomes

Yilong Li, Nicola D Roberts, Jeremiah A Wala, Ofer Shapira, Steven E Schumacher, Kiran Kumar, Ekta Khurana, Sebastian Waszak, Jan O Korbel, James E Haber, Marcin Imielinski, Joachim Weischenfeldt, Rameen Beroukhim, Peter J Campbell, Kadir C Akdemir, Eva G Alvarez, Adrian Baez-Ortega, Paul C Boutros, David DL Bowtell, Benedikt Brors, et al.

Journal article  |  2020  |  Nature

A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments th..

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Jeremiah A Wala, Ofer Shapira, Grace Tiao, Henrik Hornshoj, Julian M Hess, Randi Istrup Juul, Ziao Lin, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andres Lanzos, Carl Herrmann, Yosef E Maruvka, Ciyue Shen, et al.

Journal article  |  2020  |  Nature

The discovery of drivers of cancer has traditionally focused on protein-coding genes1-4. Here we present analyses of driver point ..

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Kadir C Akdemir, Victoria T Le, Sahaana Chandran, Yilong Li, Roel G Verhaak, Rameen Beroukhim, Peter J Campbell, Lynda Chin, Jesse R Dixon, P Andrew Futreal, Eva G Alvarez, Adrian Baez-Ortega, Rameen Beroukhim, Paul C Boutros, David DL Bowtell, Benedikt Brors, Kathleen H Burns, Kin Chan, Ken Chen, Isidro Cortes-Ciriano, et al.

Journal article  |  2020  |  Nature Genetics

High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.

Yiqun Zhang, Fengju Chen, Nuno A Fonseca, Yao He, Masashi Fujita, Hidewaki Nakagawa, Zemin Zhang, Alvis Brazma, undefined PCAWG Transcriptome Working Group, undefined PCAWG Structural Variation Working Group, Chad J Creighton, undefined PCAWG Consortium

Journal article  |  2020  |  Nature Communications

The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Here, as part of the ICGC/TCGA Pa..

Genomic footprints of activated telomere maintenance mechanisms in cancer.

Lina Sieverling, Chen Hong, Sandra D Koser, Philip Ginsbach, Kortine Kleinheinz, Barbara Hutter, Delia M Braun, Isidro Cortés-Ciriano, Ruibin Xi, Rolf Kabbe, Peter J Park, Roland Eils, Matthias Schlesner, undefined PCAWG-Structural Variation Working Group, Benedikt Brors, Karsten Rippe, David TW Jones, Lars Feuerbach, undefined PCAWG Consortium

Journal article  |  2020  |  Nature Communications

Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or ..

Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig.

Yulia Rubanova, Ruian Shi, Caitlin F Harrigan, Roujia Li, Jeff Wintersinger, Nil Sahin, Amit Deshwar, undefined PCAWG Evolution and Heterogeneity Working Group, Quaid Morris, undefined PCAWG Consortium

Journal article  |  2020  |  Nature Communications

The type and genomic context of cancer mutations depend on their causes. These causes have been characterized using signatures tha..

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Bernardo Rodriguez-Martin, Eva G Alvarez, Adrian Baez-Ortega, Jorge Zamora, Fran Supek, Jonas Demeulemeester, Martin Santamarina, Young Seok Ju, Javier Temes, Daniel Garcia-Souto, Harald Detering, Yilong Li, Jorge Rodriguez-Castro, Ana Dueso-Barroso, Alicia L Bruzos, Stefan C Dentro, Miguel G Blanco, Gianmarco Contino, Daniel Ardeljan, Marta Tojo, et al.

Journal article  |  2020  |  Nature Genetics

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Isidro Cortes-Ciriano, Jake June-Koo Lee, Ruibin Xi, Dhawal Jain, Youngsook L Jung, Lixing Yang, Dmitry Gordenin, Leszek J Klimczak, Cheng-Zhong Zhang, David S Pellman, Peter J Park, Kadir C Akdemir, Eva G Alvarez, Adrian Baez-Ortega, Rameen Beroukhim, Paul C Boutros, David DL Bowtell, Benedikt Brors, Kathleen H Burns, Peter J Campbell, et al.

Journal article  |  2020  |  Nature Genetics

Inferring structural variant cancer cell fraction.

Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schröder, undefined PCAWG Evolution and Heterogeneity Working Group, Niall M Corcoran, Tony Papenfuss, Christopher M Hovens, Florian Markowetz, Geoff Macintyre, undefined PCAWG Consortium

Journal article  |  2020  |  Nature Communications

We present SVclone, a computational method for inferring the cancer cell fraction of structural variant (SV) breakpoints from whol..

MOLECULAR AND PHENOTYPIC CHARACTERISATION OF INTRA-TUMOURAL HETEROGENEITY IN HIGH GRADE SEROUS OVARIAN CANCER

P Cunnea, E Curry, K Nixon, K Thol, R Wulandari, D Bowtell, I McNeish, C Fotopoulou

Conference Proceedings  |  2019  |  ePoster Talks: Ovarian + Endometria

LONG-TERM SURVIVAL IN WOMEN WITH HIGH-GRADE SEROUS OVARIAN CANCER: INTERPLAY BETWEEN RB1 AND BRCA1/2

FAM Saner, DW Garsed, JA Beach, A Pandey, S Fereday, K Alsop, MCA Wouters, N Traficante, CL Pearce, MC Pike, A de Fazio, SJ Ramus, M Kobel, EL Goode, BH Nelson, DDL Bowtell

Conference Proceedings  |  2019  |  Poster exhibition Day 2

Cyclin E1 is a shared biomarker of subsets of high grade serous ovarian cancer (HGSOC) and basal like breast cancer (BLBC)

D Aziz, C Lee, V Chin, K Fernandez, D Etemadmoghadam, D Bowtell, PM Waring, CE Caldon

Conference Proceedings  |  2019  |  ANNALS OF ONCOLOGY

Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer

Elizabeth H Stover, Maria B Baco, Ofir Cohen, Yvonne Y Li, Elizabeth L Christie, Mukta Bagul, Amy Goodale, Yenarae Lee, Sasha Pantel, Matthew G Rees, Guo Wei, Adam G Presser, Maya K Gelbard, Weiqun Zhang, Ioannis K Zervantonakis, Patrick D Bhola, Jeremy Ryan, Jennifer L Guerriero, Joan Montero, Felice J Liang, et al.

Journal article  |  2019  |  Molecular Cancer Research

High-grade serous ovarian cancer (HGSOC) is often sensitive to initial treatment with platinum and taxane combination chemotherapy..

POOLED GENOMIC SCREENS IDENTIFY ANTI-APOPTOTIC GENES AS MEDIATORS OF CHEMOTHERAPY RESISTANCE IN OVARIAN CANCER

Elizabeth H Stover, Maria B Baco, Ofir Cohen, Yvonne Li, Elizabeth Christie, Mukta Bagul, Amy Goodale, Yenarae Lee, Sasha Pantel, Matthew Rees, Guo Wei, Adam Presser, Ioannis Zervantonakis, Patrick Bhola, Jeremy Ryan, Jennifer Guerriero, Felice Liang, Andrew Cherniack, Federica Piccioni, Ursula A Matulonis, et al.

Conference Proceedings  |  2019  |  CLINICAL CANCER RESEARCH

Molecular Classification of Epithelial Ovarian Cancer Based on Methylation Profiling: Evidence for Survival Heterogeneity

Clara Bodelon, J Keith Killian, Joshua N Sampson, William F Anderson, Rayna Matsuno, Louise A Brinton, Jolanta Lissowska, Michael S Anglesio, David DL Bowtell, Jennifer A Doherty, Susan J Ramus, Aline Talhouk, Mark E Sherman, Nicolas Wentzensen

Journal article  |  2019  |  Clinical Cancer Research

The molecular origin and taxonomy of mucinous ovarian carcinoma

Dane Cheasley, Matthew J Wakefield, Georgina L Ryland, Prue E Allan, Kathryn Alsop, Kaushalya C Amarasinghe, Sumitra Ananda, Michael S Anglesio, George Au-Yeung, Maret Bohm, David Dl Bowtell, Alison Brand, Georgia Chenevix-Trench, Michael Christie, Yoke-Eng Chiew, Michael Churchman, Anna DeFazio, Renee Demeo, Rhiannon Dudley, Nicole Fairweather, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

Subclone-specific evolution of tumor phenotypes - A framework to study subclone-specific gene expression from a combination of bulk DNA and single cell RNA sequencing data

Yi Qiao, Xiaomeng Huang, Samuel Brady, Andrea Bild, David Bowtell, William Johnson, Gabor Marth

Conference Proceedings  |  2019  |  Tumor Biology

The genomic landscape of high-grade serous ovarian cancer in long-term survivors

Dale W Garsed, Ahwan Pandey, Sian Fereday, Kathryn Alsop, Maartje C Wouters, Flurina Saner, Jessica A Beach, Katy Milne, Catherine J Kennedy, Joy Hendley, Nadia Traficante, Celeste L Pearce, Malcolm C Pike, Susan J Ramus, Martin Kobel, Brad H Nelson, Ellen L Goode, Anna deFazio, David D Bowtell

Conference Proceedings  |  2019  |  Molecular and Cellular Biology / Genetics

Survival Following Chemotherapy in Ovarian Clear Cell Carcinoma Is Not Associated with Pathological Misclassification of Tumor Histotype

Masataka Takenaka, Martin Kobel, Dale W Garsed, Sian Fereday, Ahwan Pandey, Dariush Etemadmoghadam, Joy Hendley, Ayako Kawabata, Daito Noguchi, Nozomu Yanaihara, Hiroyuki Takahashi, Takako Kiyokawa, Masahiro Ikegami, Hirokuni Takano, Seiji Isonishi, Kazuhiko Ochiai, Nadia Traficante, Sreeja Gadipally, Timothy Semple, Dane Vassiliadis, et al.

Journal article  |  2019  |  Clinical Cancer Research

Clinical Utility of Real-Time Targeted Molecular Profiling in the Clinical Management of Ovarian Cancer: The ALLOCATE Study

Olga Kondrashova, Gwo-Yaw Ho, George Au-Yeung, Leakhena Leas, Tiffany Boughtwood, Kathryn Alsop, Giada Zapparoli, Alexander Dobrovic, Yi-An Ko, Arthur L Hsu, Clare J Love, Sebastian Lunke, Matthew J Wakefield, Orla McNally, Michael Quinn, Sumitra Ananda, Deborah Neesham, Anne Hamilton, Marisa Grossi, Alison Freimund, et al.

Journal article  |  2019  |  JCO Precision Oncology

Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference

Robert C Bast, Ursula A Matulonis, Anil K Sood, Ahmed A Ahmed, Adaobi E Amobi, Frances R Balkwill, Monicka Wielgos-Bonvallet, David DL Bowtell, James D Brenton, Joan S Brugge, Robert L Coleman, Giulio F Draetta, Kai Doberstein, Ronny I Drapkin, Mark A Eckert, Robert P Edwards, Kevin M Elias, Darren Ennis, Andrew Futreal, David M Gershenson, et al.

Journal article  |  2019  |  Cancer

A mathematical descriptor of tumour mesoscopic structure from computed tomography images annotates prognostic and molecular phenotypes of epithelial ovarian cancer

H Lu, M Arshad, A Thornton, G Avesani, P Cunnea, E Curry, F Kanavati, J Liang, K Nixon, S Williams, M Hassan, D Bowtell, H Gabra, C Fotopoulou, A Rockall, E Aboagye

Conference Proceedings  |  2019  |  BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Going to extremes: determinants of extraordinary response and survival in patients with cancer

Flurina AM Saner, Alan Herschtal, Brad H Nelson, Anna deFazio, Ellen L Goode, Susan J Ramus, Ahwan Pandey, Jessica A Beach, Sian Fereday, Andrew Berchuck, Stephanie Lheureux, Celeste Leigh Pearce, Paul D Pharoah, Malcolm C Pike, Dale W Garsed, David DL Bowtell

Journal article  |  2019  |  Nature Reviews Cancer

Describing intratumoural heterogeneity in high-grade serous ovarian cancer

K Nixon, R Wulandari, E Curry, N Rama, D Bowtell, P Cunnea, C Fotopoulou

Conference Proceedings  |  2019  |  BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Clinical impact of tissue of origin testing and mutation profiling in the Solving Unknown Primary Cancer (SUPER) national prospective study: Experience of the first two years.

Linda R Mileshkin, Tharani Sivakumaran, Dariush Etemadmoghadam, Richard Tothill, Andrew Fellowes, Stephen B Fox, Lisa Guccione, Alison E Freimund, Anna Defazio, Nicholas Wilcken, Bo Gao, Madhu Sudan Singh, Ian M Collins, Gary Edward Richardson, Christopher B Steer, Mark Andrew Warren, Christos Stelios Karapetis, Cindy Bryant, Penelope Schofield, David Bowtell

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Profound MEK inhibitor response in a cutaneous melanoma harboring a GOLGA4-RAF1 fusion

Christopher R McEvoy, Huiling Xu, Kortnye Smith, Dariush Etemadmoghadam, Huei San Leong, David Y Choong, David J Byrne, Amir Iravani, Sophie Beck, Linda Mileshkin, Richard W Tothill, David D Bowtell, Bindi M Bates, Violeta Nastevski, Judy Browning, Anthony H Bell, Chloe Khoo, Jayesh Desai, Andrew P Fellowes, Stephen B Fox, et al.

Journal article  |  2019  |  Journal of Clinical Investigation

Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer

Elizabeth L Christie, Swetansu Pattnaik, Jessica Beach, Anthony Copeland, Nineveh Rashoo, Sian Fereday, Joy Hendley, Kathryn Alsop, Samuel L Brady, Greg Lamb, Ahwan Pandey, Anna deFazio, Heather Thorne, Andrea Bild, David DL Bowtell

Journal article  |  2019  |  Nature Communications

A mathematical-descriptor of tumor-mesoscopic-structure from computed-tomography images annotates prognostic- and molecular-phenotypes of epithelial ovarian cancer

Haonan Lu, Mubarik Arshad, Andrew Thornton, Giacomo Avesani, Paula Cunnea, Ed Curry, Fahdi Kanavati, Jack Liang, Katherine Nixon, Sophie T Williams, Mona Ali Hassan, David DL Bowtell, Hani Gabra, Christina Fotopoulou, Andrea Rockall, Eric O Aboagye

Journal article  |  2019  |  Nature Communications

Ovarian Carcinoma-Associated Mesenchymal Stem Cells Arise from Tissue-Specific Normal Stroma

Lan G Coffman, Alexander T Pearson, Leonard G Frisbie, Zachary Freeman, Elizabeth Christie, David D Bowtell, Ronald J Buckanovich

Journal article  |  2019  |  STEM CELLS

Mechanisms of Drug Resistance in High-Grade Serous Ovarian Cancer

Alison E Freimund, Jessica A Beach, Elizabeth L Christie, David DL Bowtell

Journal article  |  2018  |  Hematology/Oncology Clinics of North America

Development of the optimal care pathway for cancer of unknown primary

Linda Mileshkin, Laura Holliday, Amey Aurangabadkar, David Ball, David Bowtell, Cindy Bryant, Jonathan Clark, Katherine Clark, Anthony Gill, Julie Gottlieb, Laura Kirsten, Sally Lord, Siobhan O'Neill, Richard Osborne, Penelope Schofield, Martin Tattersall, Robert Thomas, Richard Tothill, Claire Vajdic, Desmond Yip, et al.

Conference Proceedings  |  2018  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

New horizons in translational research of cancer of unknown primary

Dariush Etemadamoghadam, Atara Posner, Alexandra Murray, Sean Grimmond, Oliver Hofmann, Penelope Schofield, David Bowtell, Linda Mileshkin, Richard W Tothill

Conference Proceedings  |  2018  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

SRA737, a novel Chk1 inhibitor, shows efficacy in CCNE1-amplified and MYCN-overexpressing high-grade serous ovarian cancer patient-derived xenograft models

GY Ho, H Barker, C Vanderberg, O Kondrashova, E Kyran, E Lieschke, O McNally, A Hamilton, V Heong, R Hansen, S Milutinovic, B Strouse, M Hedrick, C Hassig, D Bowtell, W Matthew, C Scott

Conference Proceedings  |  2018  |  EUROPEAN JOURNAL OF CANCER

19q12 amplified and non-amplified subsets of high grade serous ovarian cancer with overexpression of cyclin E1 differ in their molecular drivers and clinical outcomes

Diar Aziz, Dariush Etemadmoghadam, C Elizabeth Caldon, George Au-Yeung, Niantao Deng, Ryan Hutchinson, David Bowtell, Paul Waring

Journal article  |  2018  |  Gynecologic Oncology

Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study

Peter F Rambau, Robert A Vierkant, Maria P Intermaggio, Linda E Kelemen, Marc T Goodman, Esther Herpel, Paul D Pharoah, Stefan Kommoss, Mercedes Jimenez-Linan, Beth Y Karlan, Aleksandra Gentry-Maharaj, Usha Menon, Susanna Hernando Polo, Francisco J Candido dos Reis, Jennifer Anne Doherty, Simon A Gayther, Raghwa Sharma, Melissa C Larson, Paul R Harnett, Emma Hatfield, et al.

Journal article  |  2018  |  The Journal of Pathology: Clinical Research

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria Harrell, Giada Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B Pearson, John J Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J Hutt, Scott H Kaufmann, et al.

Journal article  |  2018  |  Nature Communications

PHASE 2 STUDY OF IV VINORELBINE IN RELAPSED PLATINUM RESISTANT/ REFRACTORY C5 HIGH GRADE SEROUS, ENDOMETRIOID OR UNDIFFERENTIATED PRIMARY PERITONEUM, FALLOPIAN TUBE OR OVARIAN CANCER

V Heong, J Ye, G Au Yeung, TZ Tan, D Bowtell, R Huang, M Linda, D Tan

Conference Proceedings  |  2018  |  INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

TARGETING MYCN OVER-EXPRESSION WITH BRD4 INHIBITION IN THE PROLIFERATIVE C5 SUBTYPE OF HIGH GRADE SEROUS OVARIAN CANCER (HGSOC)

GY Ho, O Kondrashova, C Vandenberg, E Kyran, E Lieschke, V Heong, M Milevskiy, T Papenfuss, J Schroeder, J Weroha, M Dawson, D Bowtell, H Barker, M Wakefield, C Scott

Conference Proceedings  |  2018  |  INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

TP53 missense mutations associate with different metabolic pathways.

Linda E Kelemen, James D Brenton, David D Bowtell, Brooke L Fridley

Conference Proceedings  |  2018  |  CLINICAL CANCER RESEARCH

Response rates to second-line platinum-based therapy in ovarian cancer patients challenge the clinical definition of platinum resistance

Kristina Lindemann, Bo Gao, Cristina Mapagu, Sian Fereday, Catherine Emmanuel, Kathryn Alsop, Nadia Traficante, Paul R Harnett, David DL Bowtell, Anna deFazio

Journal article  |  2018  |  Gynecologic Oncology

Acquired chemotherapy resistance in high-grade serous ovarian cancer patients.

Elizabeth L Christie, Jessica Beach, Dariush Etemadmoghadam, Dale Garsed, Ann-Marie Patch, Sian Fereday, Swetansu Pattnaik, Samuel Brady, Andrea Bild, David DL Bowtell

Conference Proceedings  |  2018  |  CLINICAL CANCER RESEARCH

Australian Ovarian Cancer Assortment Trial-Allocating ovarian cancer patients into clinical trials based on molecular profiling.

Olga Kondrashova, George Au-Yeung, Leakhena Leas, Gwo-Yaw Ho, Sebastian Lunke, Kathryn Alsop, Clare Scott, Anne Hamilton, Sumitra Ananda, Alison Freimund, Michael Quinn, Orla McNally, Nadia Traficante, Tiffany Cowie, Matthew Wakefield, Arthur Hsu, Alex Dobrovic, Michael Christie, Graham Taylor, David Bowtell, et al.

Conference Proceedings  |  2018  |  CLINICAL CANCER RESEARCH

Tumor-infiltrating CD8-positive T-lymphocytes in tubo-ovarian high-grade serous cancer are associated with multiple germline variants in 22q12.1 in a genome-wide association analysis

Yanina Natanzon, Martin Kobel, Stacey J Winham, Sebastian M Armasu, Bryan M McCauley, Robert A Vierkant, Julie M Cunningham, David Bowtell, Ian G Campbell, Jenny Chang-Claude, Anna deFazio, Peter A Fasching, Mark T Goodman, Beth Y Karlan, Francesmary Modugno, Kirsten B Moysich, Roberta B Ness, Weiva Sieh, Paul D Pharoah, Susan J Ramus, et al.

Conference Proceedings  |  2018  |  Epidemiology

Clinical Importance of Myc Family Oncogene Aberrations in Epithelial Ovarian Cancer

MoonSun Jung, Amanda J Russell, Catherine Kennedy, Andrew J Gifford, Kylie-Ann Mallitt, Siva Sivarajasingam, David D Bowtell, Anna DeFazio, Michelle Haber, Murray D Norris, Michelle J Henderson

Journal article  |  2018  |  JNCI Cancer Spectrum

The evolutionary history of 2,658 cancers

Clemency Jolly, Moritz Gerstung, Ignaty Leshchiner, Stefan C Dentro, Santiago Gonzalez, Thomas J Mitchell, Yulia Rubanova, Pavana Anur, Daniel Rosebrock, Kaixian Yu, Maxime Tarabichi, Amit Deshwar, Jeff Wintersinger, Kortine Kleinheinz, Ignacio Vasquez-Garcia, Kerstin Haase, Subhajit Sengupta, Geoff Macintyre, Salem Malikic, Nilgun Donmez, et al.

Conference Proceedings  |  2018  |  Tumor Biology

Mutations in low-grade serous ovarian cancer and response to BRAF and MEK inhibitors

Tania Moujaber, Dariush Etemadmoghadam, Cristina Mapagu, Catherine Kennedy, Yoke-Eng Chiew, Casina Kan, Nikilyn Nevins, Sivatharsny Srirangan, Sian Fereday, Nadia Traficante, David Bowtell, Rosemary Balleine, Paul Harnett, Anna deFazio

Conference Proceedings  |  2018  |  Clinical Research (Excluding Clinical Trials)

Characterizing recurrent high-grade serous ovarian cancer through wholegenome sequencing

Elizabeth L Christie, Swetansu Pattnaik, Sian Fereday, Heather Thorne, Andrea Bild, David D Bowtell

Conference Proceedings  |  2018  |  Molecular and Cellular Biology / Genetics

Transducin-Like Enhancer of Split 3 (TLE3) Expression Is Associated with Taxane Sensitivity in Nonserous Ovarian Carcinoma in a Three-Cohort Study

Brian Z Ring, Rajmohan Murali, Robert A Soslow, David DL Bowtell, Sian Fereday, Anna Defazio, Nadia Traficante, Catherine J Kennedy, Alison Brand, Raghwa Sharma, Paul Harnett, Goli Samimi

Journal article  |  2018  |  Cancer Epidemiology Biomarkers & Prevention

A gene expression prognostic signature for overall survival in patients with high-grade serous ovarian cancer.

Joshua Millstein, Timothy Budden, Michael Anglesio, Aline Talhouk, Alicia Beeghly-Fadiel, Andrew Berchuck, Georgia Chenevix-Trench, Anna deFazio, Peter A Fasching, Simon Gayther, Maria Garcia, Ellen L Goode, Michelle Henderson, Gottfried E Konecny, Sandra Orsulic, David Huntsman, David Bowtell, Jennifer Doherty, Paul Pharoah, Susan J Ramus

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

REZOLVE (ANZGOG-1101): A phase 2 trial of intraperitoneal (IP) bevacizumab (bev) for recurrent ascites in advanced, chemotherapy-resistant, epithelial ovarian cancer (CR-EOC).

Katrin Marie Sjoquist, Linda R Mileshkin, Sumitra Ananda, Catherine M Shannon, David Bowtell, Sonia Yip, David Espinoza, Jeffrey C Goh, Michelle L Harrison, Magdalena Plebanski, Val Gebski, Martin R Stockler, Karen Livingstone, Monica Tang, Michael Friedlander

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

BRAF Mutations in Low-Grade Serous Ovarian Cancer and Response to BRAF Inhibition

Tania Moujaber, Dariush Etemadmoghadam, Catherine J Kennedy, Yoke-Eng Chiew, Rosemary L Balleine, Catherine Saunders, Gerard Wain, Bo Gao, Russell Hogg, Sivatharsny Srirangan, Casina Kan, Sian Fereday, Nadia Traficante, Ann-Marie Patch, John Pearson, Nicola Waddell, Sean M Grimmond, Alexander Dobrovic, David DL Bowtell, Paul R Harnett, et al.

Journal article  |  2018  |  JCO Precision Oncology

Genes Predisposed to DNA Hypermethylation during Acquired Resistance to Chemotherapy Are Identified in Ovarian Tumors by Bivalent Chromatin Domains at Initial Diagnosis

Edward Curry, Constanze Zeller, Nahal Masrour, Darren K Patten, John Gallon, Charlotte S Wilhelm-Benartzi, Sadaf Ghaem-Maghami, David D Bowtell, Robert Brown

Journal article  |  2018  |  Cancer Research

MyD88 and TLR4 Expression in Epithelial Ovarian Cancer

Matthew S Block, Robert A Vierkant, Peter F Rambau, Stacey J Winham, Philipp Wagner, Nadia Traficante, Aleksandra Toloczko, Daniel G Tiezzi, Florin Andrei Taran, Peter Sinn, Weiva Sieh, Raghwa Sharma, Joseph H Rothstein, Teresa Ramon y Cajal, Luis Paz-Ares, Oleg Oszurek, Sandra Orsulic, Roberta B Ness, Gregg Nelson, Francesmary Modugno, et al.

Journal article  |  2018  |  Mayo Clinic Proceedings

Genomic Analysis Using Regularized Regression in High-Grade Serous Ovarian Cancer

Yanina Natanzon, Madalene Earp, Julie M Cunningham, Kimberly R Kalli, Chen Wang, Sebastian M Armasu, Melissa C Larson, David DL Bowtell, Dale W Garsed, Brooke L Fridley, Stacey J Winham, Ellen L Goode

Journal article  |  2018  |  Cancer Informatics

Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer

Dale W Garsed, Kathryn Alsop, Sian Fereday, Catherine Emmanuel, Catherine J Kennedy, Dariush Etemadmoghadam, Bo Gao, Val Gebski, Valerie Gares, Elizabeth L Christie, Maartje CA Wouters, Katy Milne, Joshy George, Ann-Marie Patch, Jason Li, Gisela Mir Arnau, Timothy Semple, Sreeja R Gadipally, Yoke-Eng Chiew, Joy Hendley, et al.

Journal article  |  2018  |  Clinical Cancer Research

Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer

Timothy O'Donnell, Elizabeth L Christie, Arun Ahuja, Jacqueline Buros, B Arman Aksoy, David DL Bowtell, Alexandra Snyder, Jeff Hammerbacher

Journal article  |  2018  |  BMC Cancer

Dose-Response Association of CD8( ) Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer

Ellen L Goode, Matthew S Block, Kimberly R Kalli, Robert A Vierkant, Wenqian Chen, Zachary C Fogarty, Aleksandra Gentry-Maharaj, Aleksandra Toloczko, Alexander Hein, Aliecia L Bouligny, Allan Jensen, Ana Osorio, Andreas D Hartkopf, Andy Ryan, Anita Chudecka-Glaz, Anthony M Magliocco, Arndt Hartmann, Audrey Y Jung, Bo Gao, Brenda Y Hernandez, et al.

Journal article  |  2017  |  JAMA Oncology

DESCRIBING INTRA-TUMOURAL HETEROGENEITY IN HIGH GRADE SEROUS OVARIAN CANCER

K Nixon, P Cunnea, R Wulandari, E Curry, C Albert-Morera, N Rama, D Bowtell, H Gabra, E Stronach, C Fotopoulou

Conference Proceedings  |  2017  |  INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

DESCRIBING INTRA-TUMOURAL HETEROGENEITY IN HIGH GRADE SEROUS OVARIAN CANCER

K Nixon, P Cunnea, R Wulandari, E Curry, C Albert-Morera, N Rama, D Bowtell, H Gabra, E Stronach, C Fotopoulou

Conference Proceedings  |  2017  |  INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Acquired chemotherapy resistance in ovarian cancer

EL Christie, DDL Bowtell

Journal article  |  2017  |  Annals of Oncology

Mechanisms and clinical implications of tumor heterogeneity and convergence on recurrent phenotypes

Jasmine A McQuerry, Jeffrey T Chang, David DL Bowtell, Adam Cohen, Andrea H Bild

Journal article  |  2017  |  Journal of Molecular Medicine

Elevation of TP53 Autoantibody Before CA125 in Preclinical Invasive Epithelial Ovarian Cancer

Wei-Lei Yang, Aleksandra Gentry-Maharaj, Archana Simmons, Andy Ryan, Evangelia Ourania Fourkala, Zhen Lu, Keith A Baggerly, Yang Zhao, Karen H Lu, David Bowtell, Ian Jacobs, Steven J Skates, Wei-Wu He, Usha Menon, Robert C Bast

Journal article  |  2017  |  Clinical Cancer Research

Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

Olga Kondrashova, Minh Nguyen, Kristy Shield-Artin, Anna V Tinker, Nelson NH Teng, Maria I Harrell, Michael J Kuiper, Gwo-Yaw Ho, Holly Barker, Maria Jasin, Rohit Prakash, Elizabeth M Kass, Meghan R Sullivan, Gregory J Brunette, Kara A Bernstein, Robert L Coleman, Anne Floquet, Michael Friedlander, Ganessan Kichenadasse, David M O'Malley, et al.

Journal article  |  2017  |  Cancer Discovery

EIF1AX and NRAS Mutations Co-occur and Cooperate in Low-Grade Serous Ovarian Carcinomas

Dariush Etemadmoghadam, Walid J Azar, Ying Lei, Tania Moujaber, Dale W Garsed, Catherine J Kennedy, Sian Fereday, Chris Mitchell, Yoke-Eng Chiew, Joy Hendley, Raghwa Sharma, Paul R Harnett, Jason Li, Elizabeth L Christie, Ann-Marie Patch, Joshy George, George Au-Yeung, Gisela Mir Arnau, Timothy P Holloway, Timothy Semple, et al.

Journal article  |  2017  |  Cancer Research

Long-Term Responders on Olaparib Maintenance in High-Grade Serous Ovarian Cancer: Clinical and Molecular Characterization

Stephanie Lheureux, Zhongwu Lai, Brian A Dougherty, Sarah Runswick, Darren R Hodgson, Kirsten M Timms, Jerry S Lanchbury, Stan Kaye, Charlie Gourley, David Bowtell, Elise C Kohn, Claire Scott, Ursula Matulonis, Tony Panzarella, Katherine Karakasis, Julia V Burnier, C Blake Gilks, Mark J O'Connor, Jane D Robertson, Jonathan Ledermann, et al.

Journal article  |  2017  |  Clinical Cancer Research

Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene

Ed Dicks, Honglin Song, Susan J Ramus, Elke Van Oudenhove, Jonathan P Tyrer, Maria P Intermaggio, Siddhartha Kar, Patricia Harrington, David D Bowtell, Mine S Cicek, Julie M Cunningham, Brooke L Fridley, Jennifer Alsop, Mercedes Jimenez-Linan, Anna Piskorz, Teodora Goranova, Emma Kent, Nadeem Siddiqui, James Paul, Robin Crawford, et al.

Journal article  |  2017  |  Oncotarget

Traceback: A Proposed Framework to Increase Identification and Genetic Counseling of BRCA1 and BRCA2 Mutation Carriers Through Family-Based Outreach

Goli Samimi, Marcus Q Bernardini, Lawrence C Brody, Charlisse F Caga-anan, Ian G Campbell, Georgia Chenevix-Trench, Fergus J Couch, Michael Dean, Joanne A de Hullu, Susan M Domchek, Ronny Drapkin, Heather Spencer Feigelson, Michael Friedlander, Mia M Gaudet, Marline G Harmsen, Karen Hurley, Paul A James, Janice S Kwon, Felicitas Lacbawan, Stephanie Lheureux, et al.

Journal article  |  2017  |  Journal of Clinical Oncology

Hedgehog inhibition impaired platinum response in high-grade serous ovarian cancer harboring high hedgehog ligand expression and mTOR pathway activation.

Gwo Yaw Ho, Elizabeth Lieschke, Elizabeth Kyran, Kristy Shield-Artin, Olga Kondrashova, Holly Barker, Robert Hollian, Aurelie Cazet, Phuong Thuan, Alex Swarbrick, Orla McNally, David Bowtell, Matthew Wakefield, Clare L Scott

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

Reversion of BRCA1/2 Germline Mutations Detected in Circulating Tumor DNA From Patients With High-Grade Serous Ovarian Cancer

Elizabeth L Christie, Sian Fereday, Ken Doig, Swetansu Pattnaik, Sarah-Jane Dawson, David DL Bowtell

Journal article  |  2017  |  Journal of Clinical Oncology

Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition

George Au-Yeung, Franziska Lang, Walid J Azar, Chris Mitchell, Kate E Jarman, Kurt Lackovic, Diar Aziz, Carleen Cullinane, Richard B Pearson, Linda Mileshkin, Danny Rischin, Alison M Karst, Ronny Drapkin, Dariush Etemadmoghadam, David DL Bowtell

Journal article  |  2017  |  Clinical Cancer Research

A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers

MoonSun Jung, Amanda J Russell, Bing Liu, Joshy George, Pei Yan Liu, Tao Liu, Anna DeFazio, David DL Bowtell, Andre Oberthuer, Wendy B London, Jamie I Fletcher, Michelle Haber, Murray D Norris, Michelle J Henderson

Journal article  |  2017  |  Cancer Research

Circulating Tumor DNA Analysis and Functional Imaging Provide Complementary Approaches for Comprehensive Disease Monitoring in Metastatic Melanoma

Stephen Q Wong, Jeanette M Raleigh, Jason Callahan, Ismael A Vergara, Sarah Ftouni, Athena Hatzimihalis, Andrew J Colebatch, Jason Li, Timothy Semple, Kenneth Doig, Christopher Mintoff, Devbarna Sinha, Paul Yeh, Maria Joao Silva, Kathryn Alsop, Heather Thorne, David D Bowtell, David E Gyorki, Gisela Mir Arnau, Carleen Cullinane, et al.

Journal article  |  2017  |  JCO Precision Oncology

Long-term survival of patients with mismatch repair protein-deficient, high-stage ovarian clear cell carcinoma

Colin JR Stewart, David DL Bowtell, Dorota A Doherty, Yee C Leung

Journal article  |  2017  |  Histopathology

Commentary on "Epithelial-to-Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer"

Jessica A Beach, David DL Bowtell

Journal article  |  2016  |  Cancer Research

The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.

Kristie-Ann Dickson, Alexander J Cole, Anthony J Gill, Adele Clarkson, Gregory B Gard, Angela Chou, Catherine J Kennedy, Beric R Henderson, undefined Australian Ovarian Cancer Study (AOCS), Sian Fereday, Nadia Traficante, Kathryn Alsop, David D Bowtell, Anna deFazio, Roderick Clifton-Bligh, Deborah J Marsh

Journal article  |  2016  |  Human Molecular Genetics

Enzymatic factors driving cancer-associated chromatin remodelling are of increasing interest as the role of the cancer epigenome i..

The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE"

Peter Savas, Zhi Ling Teo, Christophe Lefevre, Christoffer Flensburg, Franco Caramia, Kathryn Alsop, Mariam Mansour, Prudence A Francis, Heather A Thorne, Maria Joao Silva, Nnennaya Kanu, Michelle Dietzen, Andrew Rowan, Maik Kschischo, Stephen Fox, David D Bowtell, Sarah-Jane Dawson, Terence P Speed, Charles Swanton, Sherene Loi

Journal article  |  2016  |  PLOS Medicine

Blood Worth Bottling: Circulating Tumor DNA as a Cancer Biomarker

Elizabeth L Christie, Sarah-Jane Dawson, David DL Bowtell

Journal article  |  2016  |  Cancer Research

Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis

Sebastian Moran, Anna Martinez-Cardus, Sergi Sayols, Eva Musulen, Carme Balana, Anna Estival-Gonzalez, Catia Moutinho, Holger Heyn, Angel Diaz-Lagares, Manuel Castro de Moura, Giulia M Stella, Paolo M Comoglio, Maria Ruiz-Miro, Xavier Matias-Guiu, Roberto Pazo-Cid, Antonio Anton, Rafael Lopez-Lopez, Gemma Soler, Federico Longo, Isabel Guerra, et al.

Journal article  |  2016  |  The Lancet Oncology

A community-based model of rapid autopsy in end-stage cancer patients

Kathryn Alsop, Heather Thorne, Shahneen Sandhu, Anne Hamilton, Christopher Mintoff, Elizabeth Christie, Odette Spruyt, Scott Williams, Orla McNally, Linda Mileshkin, Sumitra Ananda, Julene Hallo, Sherene Loi, Clare Scott, Peter Savas, Lisa Devereux, Patricia O'Brien, Sameera Gunawardena, Clare Hampson, Kate Strachan, et al.

Journal article  |  2016  |  Nature Biotechnology

Serous ovarian and primary peritoneal cancers: A comparative analysis of clinico-pathological features, molecular subtypes and treatment outcome

Bo Gao, Kristina Lindemann, Lyndal Anderson, Sian Fereday, Jillian Hung, Kathryn Alsop, Richard W Tothill, Val Gebski, Catherine Kennedy, Rosemary L Balleine, Paul R Harnett, David DL Bowtell, Anna DeFazio

Journal article  |  2016  |  Gynecologic Oncology

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

Kate Lawrenson, Siddhartha Kar, Karen McCue, Karoline Kuchenbaeker, Kyriaki Michailidou, Jonathan Tyrer, Jonathan Beesley, Susan J Ramus, Qiyuan Li, Melissa K Delgado, Janet M Lee, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Banu K Arun, Brita Arver, Elisa V Bandera, Monica Barile, Rosa B Barkardottir, et al.

Journal article  |  2016  |  NATURE COMMUNICATIONS

Pericytes Promote Malignant Ovarian Cancer Progression in Mice and Predict Poor Prognosis in Serous Ovarian Cancer Patients

Devbarna Sinha, Lynn Chong, Joshy George, Holger Schlueter, Susann Moenchgesang, Stuart Mills, Jason Li, Christopher Parish, David Bowtell, Pritinder Kaur

Journal article  |  2016  |  CLINICAL CANCER RESEARCH

Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer

Stacey J Winham, Ailith Pirie, Yian Ann Chen, Melissa C Larson, Zachary C Fogarty, Madalene A Earp, Hoda Anton-Culver, Elisa V Bandera, Daniel Cramer, Jennifer A Doherty, Marc T Goodman, Jacek Gronwald, Beth Y Karlan, Susanne K Kjaer, Douglas A Levine, Usha Menon, Roberta B Ness, Celeste L Pearce, Tanja Pejovic, Mary Anne Rossing, et al.

Journal article  |  2016  |  Cancer Epidemiology Biomarkers & Prevention

PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations

Paul DP Pharoah, Honglin Song, Ed Dicks, Maria P Intermaggio, Patricia Harrington, Caroline Baynes, Kathryn Alsop, Natalia Bogdanova, Mine S Cicek, Julie M Cunningham, Brooke L Fridley, Aleksandra Gentry-Maharaj, Peter Hillemanns, Shashi Lele, Jenny Lester, Valerie McGuire, Kirsten B Moysich, Samantha Poblete, Weiva Sieh, Lara Sucheston-Campbell, et al.

Journal article  |  2016  |  Journal of the National Cancer Institute

Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type

Anthony N Karnezis, Yemin Wang, Pilar Ramos, William PD Hendricks, Esther Oliva, Emanuela D'Angelo, Jaime Prat, Marisa R Nucci, Torsten O Nielsen, Christine Chow, Samuel Leung, Friedrich Kommoss, Stefan Kommoss, Annacarolina Silva, Brigitte M Ronnett, Joseph T Rabban, David D Bowtell, Bernard E Weissman, Jeffrey M Trent, C Blake Gilks, et al.

Journal article  |  2016  |  The Journal of Pathology

UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas

Stephen Q Wong, Kelly Waldeck, Ismael A Vergara, Jan Schroeder, Jason Madore, James S Wilmott, Andrew J Colebatch, Ricardo De Paoli-Iseppi, Jason Li, Richard Lupat, Timothy Semple, Gisela Mir Arnau, Andrew Fellowes, J Helen Leonard, George Hruby, Graham J Mann, John F Thompson, Carleen Cullinane, Meredith Johnston, Mark Shackleton, et al.

Journal article  |  2015  |  Cancer Res

Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium

Sharon E Johnatty, Jonathan P Tyrer, Siddhartha Kar, Jonathan Beesley, Yi Lu, Bo Gao, Peter A Fasching, Alexander Hein, Arif B Ekici, Matthias W Beckmann, Diether Lambrechts, Els Van Nieuwenhuysen, Ignace Vergote, Sandrina Lambrechts, Mary Anne Rossing, Jennifer A Doherty, Jenny Chang-Claude, Francesmary Modugno, Roberta B Ness, Kirsten B Moysich, et al.

Journal article  |  2015  |  Clinical Cancer Research

High-Throughput Amplicon-Based Copy Number Detection of 11 Genes in Formalin-Fixed Paraffin-Embedded Ovarian Tumour Samples by MLPA-Seq

Olga Kondrashova, Clare J Love, Sebastian Lunke, Arthur L Hsu, Paul M Waring, Graham R Taylor

Journal article  |  2015  |  PLOS ONE

Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes

SM Hunter, MS Anglesio, GL Ryland, R Sharma, YE Chiew, SM Rowley, MA Doyle, J Li, CB Gilks, P Moss, PE Allan, AN Stephens, DG Huntsman, A deFazio, DD Bowtell, G Australian Ovarian Cancer Study, KL Gorringe, IG Campbell

Journal article  |  2015  |  Oncotarget

Low grade serous ovarian tumours are a rare and under-characterised histological subtype of epithelial ovarian tumours, with littl..

Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer

Susan J Ramus, Honglin Song, Ed Dicks, Jonathan P Tyrer, Adam N Rosenthal, Maria P Intermaggio, Lindsay Fraser, Aleksandra Gentry-Maharaj, Jane Hayward, Susan Philpott, Christopher Anderson, Christopher K Edlund, David Conti, Patricia Harrington, Daniel Barrowdale, David D Bowtell, Kathryn Alsop, Gillian Mitchell, Mine S Cicek, Julie M Cunningham, et al.

Journal article  |  2015  |  JNCI: Journal of the National Cancer Institute

The ubiquitin ligase Siah2 regulates obesity-induced adipose tissue inflammation

Gail Kilroy, Lauren E Carter, Susan Newman, David H Burk, Justin Manuel, Andreas Moeller, David D Bowtell, Randall L Mynatt, Sujoy Ghosh, Z Elizabeth Floyd

Journal article  |  2015  |  Obesity

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

David D Bowtell, Steffen Boehm, Ahmed A Ahmed, Paul-Joseph Aspuria, Robert C Bast, Valerie Beral, Jonathan S Berek, Michael J Birrer, Sarah Blagden, Michael A Bookman, James D Brenton, Katherine B Chiappinelli, Filipe Correia Martins, George Coukos, Ronny Drapkin, Richard Edmondson, Christina Fotopoulou, Hani Gabra, Jerome Galon, Charlie Gourley, et al.

Journal article  |  2015  |  Nature Reviews Cancer

Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population

Honglin Song, Ed Dicks, Susan J Ramus, Jonathan P Tyrer, Maria P Intermaggio, Jane Hayward, Christopher K Edlund, David Conti, Patricia Harrington, Lindsay Fraser, Susan Philpott, Christopher Anderson, Adam Rosenthal, Aleksandra Gentry-Maharaj, David D Bowtell, Kathryn Alsop, Mine S Cicek, Julie M Cunningham, Brooke L Fridley, Jennifer Alsop, et al.

Journal article  |  2015  |  Journal of Clinical Oncology

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Kate Lawrenson, Qiyan Li, Siddhartha Kar, Ji-Heui Seo, Jonathan Tyrer, Tassja J Spindler, Janet Lee, Yibu Chen, Alison Karst, Ronny Drapkin, Katja KH Aben, Hoda Anton-Culver, Natalia Antonenkova, Helen Baker, Elisa V Bandera, Yukie Bean, Matthias W Beckmann, Andrew Berchuck, Maria Bisogna, Line Bjorge, et al.

Journal article  |  2015  |  Nature Communications

Mutational landscape of mucinous ovarian carcinoma and its neoplastic precursors

Georgina L Ryland, Sally M Hunter, Maria A Doyle, Franco Caramia, Jason Li, Simone M Rowley, Michael Christie, Prue E Allan, Andrew N Stephens, David DL Bowtell, Ian G Campbell, Kylie L Gorringe

Journal article  |  2015  |  GENOME MEDICINE

Loss of heterozygosity: what is it good for?

Georgina L Ryland, Maria A Doyle, David Goode, Samantha E Boyle, David YH Choong, Simone M Rowley, Jason Li, David DL Bowtell, Richard W Tothill, Ian G Campbell, Kylie L Gorringe

Journal article  |  2015  |  BMC Med Genomics

Efficient molecular subtype classification of high-grade serous ovarian cancer

Huei San Leong, Laura Galletta, Dariush Etemadmoghadam, Joshy George, Martin Koebel, Susan J Ramus, David Bowtell

Journal article  |  2015  |  The Journal of Pathology

Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition

Sally J Davis, Karen E Sheppard, Michael S Anglesio, Joshy George, Nadia Traficante, Sian Fereday, Maria P Intermaggio, Usha Menon, Aleksandra Gentry-Maharaj, Jan Lubinski, Jacek Gronwald, Celeste Leigh Pearce, Malcolm C Pike, Anna Wu, Stefan Kommoss, Jacobus Pfisterer, Andreas du Bois, Felix Hilpert, Susan J Ramus, David DL Bowtell, et al.

Journal article  |  2015  |  MOLECULAR CANCER THERAPEUTICS

Whole-genome characterization of chemoresistant ovarian cancer

Ann-Marie Patch, Elizabeth L Christie, Dariush Etemadmoghadam, Dale W Garsed, Joshy George, Sian Fereday, Katia Nones, Prue Cowin, Kathryn Alsop, Peter J Bailey, Karin S Kassahn, Felicity Newell, Michael CJ Quinn, Stephen Kazakoff, Kelly Quek, Charlotte Wilhelm-Benartzi, Ed Curry, Huei San Leong, Anne Hamilton, Linda Mileshkin, et al.

Journal article  |  2015  |  Nature

Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer

Carla S Milagrel, Ganga Gopinathanl, Gemma Everitt, Richard G Thompson, Hagen Kulbel, Haihong Zhong, Robert E Hollingsworth, Richard Grose, David DL Bowte, Daniel Hochhauserzl, Frances R Balkwilll

Journal article  |  2015  |  Cancer Research

CARCINOMA OF UNKNOWN PRIMARY - RARE BUT RIPE FOR HELP FROM GENOMICS?

Lisa Guccione, Linda Mileshkin, Penelope Schofield, David Bowtell

Journal article  |  2015  |  Cancer Forum

Connecting patients, researchers and clinical genetics services: the experiences of participants in the Australian Ovarian Cancer Study (AOCS)

Ashley Crook, Loren Plunkett, Laura E Forrest, Nina Hallowell, Samantha Wake, Kathryn Alsop, Margaret Gleeson, David Bowtell, Gillian Mitchell, Mary-Anne Young

Journal article  |  2015  |  European Journal of Human Genetics

Germline Mutation in BRCA1 or BRCA2 and Ten-Year Survival for Women Diagnosed with Epithelial Ovarian Cancer

Francisco J Candido-dos-Reis, Honglin Song, Ellen L Goode, Julie M Cunningham, Brooke L Fridley, Melissa C Larson, Kathryn Alsop, Ed Dicks, Patricia Harrington, Susan J Ramus, Anna de Fazio, Gillian Mitchell, Sian Fereday, Kelly L Bolton, Charlie Gourley, Caroline Michie, Beth Karlan, Jenny Lester, Christine Walsh, Ilana Cass, et al.

Journal article  |  2015  |  CLINICAL CANCER RESEARCH

The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer

Anna Chen, Christina SF Wong, Mira CP Liu, Colin M House, Jaclyn Sceneay, David D Bowtell, Erik W Thompson, Andreas Moeller

Journal article  |  2015  |  Oncotarget

Development and validation of a gene expression tumour classifier for cancer of unknown primary

Richard W Tothill, Fan Shi, Lisa Paiman, Justin Bedo, Adam Kowalczyk, Linda Mileshkin, Evangeline Buela, Robert Klupacs, David Bowtell, Keith Byron

Journal article  |  2015  |  Pathology

A dual role for Caspase8 and NF-kappa B interactions in regulating apoptosis and necroptosis of ovarian cancer, with correlation to patient survival

L Hernandez, MK Kim, AM Noonan, E Sagher, H Kohlhammer, G Wright, LT Lyle, PS Steeg, M Anver, DD Bowtell, CM Annunziata

Journal article  |  2015  |  Cell Death Discovery

Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver

Catherine Emmanuel, Yoke-Eng Chiew, Joshy George, Dariush Etemadmoghadam, Michael S Anglesio, Raghwa Sharma, Peter Russell, Catherine Kennedy, Sian Fereday, Jillian Hung, Laura Galletta, Russell Hogg, Gerard V Wain, Alison Brand, Rosemary Balleine, Laura MacConaill, Emanuele Palescandolo, Sally M Hunter, Ian Campbell, Alexander Dobrovic, et al.

Journal article  |  2014  |  Clinical Cancer Research

Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study

M Koebel, J Madore, SJ Ramus, BA Clarke, PDP Pharoah, S Deen, DD Bowtell, K Odunsi, U Menon, C Morrison, S Lele, W Bshara, L Sucheston, MW Beckmann, A Hein, FC Thiel, A Hartmann, DL Wachter, MS Anglesio, E Hogdall, et al.

Journal article  |  2014  |  British Journal of Cancer

AKT1 gene amplification as a biomarker of treatment response in ovarian cancer: Mounting evidence of a therapeutic target

Dariush Etemadmoghadam, David Bowtell

Journal article  |  2014  |  Gynecologic Oncology

Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion

Hilary A Kenny, Chun-Yi Chiang, Erin A White, Elizabeth M Schryver, Mohammed Habis, Iris L Romero, Andras Ladanyi, Carla V Penicka, Joshy George, Karl Matlin, Anthony Montag, Kristen Wroblewski, S Diane Yamada, Andrew P Mazar, David Bowtell, Ernst Lengyel

Journal article  |  2014  |  Journal of Clinical Investigation

Highlights from the 2014 American Association for Cancer Research Annual Meeting.

David D Bowtell, Ronny Drapkin

Journal article  |  2014  |  Gynecologic Oncology

ABCA Transporter Gene Expression and Poor Outcome in Epithelial Ovarian Cancer

Ellen L Hedditch, Bo Gao, Amanda J Russell, Yi Lu, Catherine Emmanuel, Jonathan Beesley, Sharon E Johnatty, Xiaoqing Chen, Paul Harnett, Joshy George, Rebekka T Williams, Claudia Flemming, Diether Lambrechts, Evelyn Despierre, Sandrina Lambrechts, Ignace Vergote, Beth Karlan, Jenny Lester, Sandra Orsulic, Christine Walsh, et al.

Journal article  |  2014  |  JNCI: Journal of the National Cancer Institute

Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Bo Gao, Amanda Russell, Jonathan Beesley, Xiao Qing Chen, Sue Healey, Michelle Henderson, Mark Wong, Catherine Emmanuel, Laura Galletta, Sharon E Johnatty, David Bowtell, Michelle Haber, Murray Norris, Paul Harnett, Georgia Chenevix-Trench, Rosemary L Balleine, Anna deFazio

Journal article  |  2014  |  SCIENTIFIC REPORTS

Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts

Monique D Topp, Lynne Hartley, Michele Cook, Valerie Heong, Emma Boehm, Lauren McShane, Jan Pyman, Orla McNally, Sumitra Ananda, Marisol Harrell, Dariush Etemadmoghadam, Laura Galletta, Kathryn Alsop, Gillian Mitchell, Stephen B Fox, Jeffrey B Kerr, Karla J Hutt, Scott H Kaufmann, Elizabeth M Swisher, David D Bowtell, et al.

Journal article  |  2014  |  Molecular Oncology

Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2

Marzia Scortegagna, Hyungsoo Kim, Jian-Liang Li, Hang Yao, Laurence M Brill, Jaeseok Han, Eric Lau, David Bowtell, Gabriel Haddad, Randal J Kaufman, Ze'ev A Ronai

Journal article  |  2014  |  PLoS Genetics

Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability

H Kim, G Claps, A Moeller, D Bowtell, X Lu, ZA Ronai

Journal article  |  2014  |  Oncogene

Processed pseudogenes acquired somatically during cancer development

Susanna L Cooke, Adam Shlien, John Marshall, Christodoulos P Pipinikas, Inigo Martincorena, Jose MC Tubio, Yilong Li, Andrew Menzies, Laura Mudie, Manasa Ramakrishna, Lucy Yates, Helen Davies, Niccolo Bolli, Graham R Bignell, Patrick S Tarpey, Sam Behjati, Serena Nik-Zainal, Elli Papaemmanuil, Vitor H Teixeira, Keiran Raine, et al.

Journal article  |  2014  |  Nature Communications

Cyclin E1 Deregulation Occurs Early in Secretory Cell Transformation to Promote Formation of Fallopian Tube-Derived High-Grade Serous Ovarian Cancers

Alison M Karst, Paul M Jones, Natalie Vena, Azra H Ligon, Joyce F Liu, Michelle S Hirsch, Dariush Etemadmoghadam, David DL Bowtell, Ronny Drapkin

Journal article  |  2014  |  CANCER RESEARCH

Activation of YAP1 Is Associated with Poor Prognosis and Response to Taxanes in Ovarian Cancer

Woojin Jeong, Sang-Bae Kim, Bo Hwa Sohn, Yun-Yong Park, Eun Sung Park, Sang Cheol Kim, Sung Soo Kim, Randy L Johnson, Michael Birrer, David SL Bowtell, Gordon B Mills, Anil Sood, Ju-Seog Lee

Journal article  |  2014  |  Anticancer Research

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

Karen E Sheppard, Carleen Cullinane, Katherine M Hannan, Meaghan Wall, Joanna Chan, Frances Barber, Jung Foo, Donald Cameron, Amelia Neilsen, Pui Ng, Jason Ellul, Margarete Kleinschmidt, Kathryn M Kinross, David D Bowtell, James G Christensen, Rodney J Hicks, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Wayne A Phillips, et al.

Journal article  |  2013  |  EUROPEAN JOURNAL OF CANCER

Massively-parallel sequencing assists the diagnosis and guided treatment of cancers of unknown primary

Richard W Tothill, Jason Li, Linda Mileshkin, Ken Doig, Terence Siganakis, Prue Cowin, Andrew Fellowes, Timothy Semple, Stephen Fox, Keith Byron, Adam Kowalczyk, David Thomas, Penelope Schofield, David D Bowtell

Journal article  |  2013  |  JOURNAL OF PATHOLOGY

Synthetic lethality between CCNE1 amplification and loss of BRCA1

Dariush Etemadmoghadam, Barbara A Weir, George Au-Yeung, Kathryn Alsop, Gillian Mitchell, Joshy George, Sally Davis, Alan D D'Andrea, Kaylene Simpson, William C Hahn, David DL Bowtell

Journal article  |  2013  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resistance to CDK2 Inhibitors Is Associated with Selection of Polyploid Cells in CCNE1-Amplified Ovarian Cancer

Dariush Etemadmoghadam, George Au-Yeung, Meaghan Wall, Chris Mitchell, Maya Kansara, Elizabeth Loehrer, Crisoula Batzios, Joshy George, Sarah Ftouni, Barbara A Weir, Scott Carter, Irma Gresshoff, Linda Mileshkin, Danny Rischin, William C Hahn, Paul M Waring, Gad Getz, Carleen Cullinane, Lynda J Campbell, David D Bowtell

Journal article  |  2013  |  CLINICAL CANCER RESEARCH

Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study

Weiva Sieh, Martin Koebel, Teri A Longacre, David D Bowtell, Anna defazio, Marc T Goodman, Estrid Hogdall, Suha Deen, Nicolas Wentzensen, Kirsten B Moysich, James D Brenton, Blaise A Clarke, Usha Menon, C Blake Gilks, Andre Kim, Jason Madore, Sian Fereday, Joshy George, Laura Galletta, Galina Lurie, et al.

Journal article  |  2013  |  LANCET ONCOLOGY

Nonequivalent Gene Expression and Copy Number Alterations in High-Grade Serous Ovarian Cancers with BRCA1 and BRCA2 Mutations

Joshy George, Kathryn Alsop, Dariush Etemadmoghadam, Heather Hondow, Thomas Mikeska, Alexander Dobrovic, Anna DeFazio, Gordon K Smyth, Douglas A Levine, Gillian Mitchell, David D Bowtell

Journal article  |  2013  |  CLINICAL CANCER RESEARCH

The Antioxidant N-Acetylcysteine Prevents HIF-1 Stabilization under Hypoxia In Vitro but Does Not Affect Tumorigenesis in Multiple Breast Cancer Models In Vivo

Jaclyn Sceneay, Mira CP Liu, Anna Chen, Christina SF Wong, David DL Bowtell, Andreas Moeller

Journal article  |  2013  |  PLoS One

The responses of research participants and their next of kin to receiving feedback of genetic test results following participation in the Australian Ovarian Cancer Study

Nina Hallowell, Kathryn Alsop, Margaret Gleeson, Ashley Crook, Loren Plunkett, David Bowtell, Gillian Mitchell, Mary-Anne Young

Journal article  |  2013  |  GENETICS IN MEDICINE

Differentiating stage 1 epithelial ovarian cancer from benign ovarian tumours using a combination of tumour markers HE4, CA125, and CEA and patient's age

Srinivas Kondalsamy-Chennakesavan, Andreas Hackethal, David Bowtell, Andreas Obermair

Journal article  |  2013  |  Gynecologic Oncology

Siah2-deficient mice show impaired skin wound repair

James N Musyoka, Mira CP Liu, Dodie S Pouniotis, Christina SF Wong, David D Bowtell, Peter J Little, Robel Getachew, Andreas Moeller, Ian A Darby

Journal article  |  2013  |  Wound Repair and Regeneration

No evidence for PALB2 methylation in high-grade serous ovarian cancer

Thomas Mikeska, Kathryn Alsop, Gillian Mitchell, David DL Bowtell, Alexander Dobrovic

Journal article  |  2013  |  JOURNAL OF OVARIAN RESEARCH

The E3 Ubiquitin Ligase Siah2 Contributes to Castration-Resistant Prostate Cancer by Regulation of Androgen Receptor Transcriptional Activity

Jianfei Qi, Manisha Tripathi, Rajeev Mishra, Natasha Sahgal, Ladan Fazil, Susan Ettinger, William J Placzek, Giuseppina Claps, Leland WK Chung, David Bowtell, Martin Gleave, Neil Bhowmick, Ze'ev A Ronai

Journal article  |  2013  |  Cancer Cell

Interaction Domains of Sos1/Grb2 Are Finely Tuned for Cooperative Control of Embryonic Stem Cell Fate

Greg M Findlay, Matthew J Smith, Fredrik Lanner, Marilyn S Hsiung, Gerald D Gish, Evangelia Petsalaki, Katie Cockburn, Tomonori Kaneko, Haiming Huang, Richard D Bagshaw, Troy Ketela, Monika Tucholska, Lorne Taylor, David D Bowtell, Jason Moffat, Mitsuhiko Ikura, Shawn SC Li, Sachdev S Sidhu, Janet Rossant, Tony Pawson

Journal article  |  2013  |  Cell

RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary

Georgina L Ryland, Sally M Hunter, Maria A Doyle, Simone M Rowley, Michael Christie, Prue E Allan, David DL Bowtell, Kylie L Gorringe, Ian G Campbell

Journal article  |  2013  |  Journal of Pathology

High Levels of Genomic Aberrations in Serous Ovarian Cancers Are Associated with Better Survival

Lars O Baumbusch, Aslaug Helland, Yun Wang, Knut Liestol, Marci E Schaner, Ruth Holm, Dariush Etemadmoghadam, Kathryn Alsop, Pat Brown, Gillian Mitchell, Sian Fereday, Anna DeFazio, David DL Bowtell, Gunnar B Kristensen, Ole Christian Lingjaerde, Anne-Lise Borresen-Dale

Journal article  |  2013  |  PLoS One

Identifying Associations Between Genomic Alterations in Tumors

Joshy George, Kylie L Gorringe, Gordon K Smyth, David DL Bowtell

Book Chapter  |  2013  |  Methods in Molecular Biology

Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomas

Michael S Anglesio, Stefan Kommoss, Mary C Tolcher, Blaise Clarke, Laura Galletta, Henry Porter, Sambasivarao Damaraju, Sian Fereday, Boris J Winterhoff, Steve E Kalloger, Janine Senz, Winnie Yang, Helen Steed, Ghassan Allo, Sarah Ferguson, Patricia Shaw, Attila Teoman, Joaquin J Garcia, John K Schoolmeester, Jamie Bakkum-Gamez, et al.

Journal article  |  2013  |  JOURNAL OF PATHOLOGY

Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

Roel GW Verhaak, Pablo Tamayo, Ji-Yeon Yang, Diana Hubbard, Hailei Zhang, Chad J Creighton, Sian Fereday, Michael Lawrence, Scott L Carter, Craig H Mermel, Aleksandar D Kostic, Dariush Etemadmoghadam, Gordon Saksena, Kristian Cibulskis, Sekhar Duraisamy, Keren Levanon, Carrie Sougnez, Aviad Tsherniak, Sebastian Gomez, Robert Onofrio, et al.

Journal article  |  2013  |  Journal of Clinical Investigation

A Role for Common Genomic Variants in the Assessment of Familial Breast Cancer

Sarah Sawyer, Gillian Mitchell, Joanne McKinley, Georgia Chenevix-Trench, Jonathan Beesley, Xiao Qing Chen, David Bowtell, Alison H Trainer, Marion Harris, Geoffrey J Lindeman, Paul A James

Journal article  |  2012  |  JOURNAL OF CLINICAL ONCOLOGY

Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome

Zhigang C Wang, Nicolai Juul Birkbak, Aedin C Culhane, Ronny Drapkin, Aquila Fatima, Ruiyang Tian, Matthew Schwede, Kathryn Alsop, Kathryn E Daniels, Huiying Piao, Joyce Liu, Dariush Etemadmoghadam, Alexander Miron, Helga B Salvesen, Gillian Mitchell, Anna DeFazio, John Quackenbush, Ross S Berkowitz, J Dirk Iglehart, David DL Bowtell, et al.

Journal article  |  2012  |  Clinical Cancer Research

Pre-Invasive Ovarian Mucinous Tumors Are Characterized by CDKN2A and RAS Pathway Aberrations

Sally M Hunter, Kylie L Gorringe, Michael Christie, Simone M Rowley, David D Bowtell, Ian G Campbell

Journal article  |  2012  |  CLINICAL CANCER RESEARCH

Primary Tumor Hypoxia Recruits CD11b( )/Ly6C(med)/Ly6G( ) Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche

Jaclyn Sceneay, Melvyn T Chow, Anna Chen, Heloise M Halse, Christina SF Wong, Daniel M Andrews, Erica K Sloan, Belinda S Parker, David D Bowtell, Mark J Smyth, Andreas Moeller

Journal article  |  2012  |  Cancer Research

LRP1B Deletion in High-Grade Serous Ovarian Cancers Is Associated with Acquired Chemotherapy Resistance to Liposomal Doxorubicin

Prue A Cowin, Joshy George, Sian Fereday, Elizabeth Loehrer, Peter Van Loo, Carleen Cullinane, Dariush Etemadmoghadam, Sarah Ftouni, Laura Galletta, Michael S Anglesio, Joy Hendley, Leanne Bowes, Karen E Sheppard, Elizabeth L Christie, Richard B Pearson, Paul R Harnett, Viola Heinzelmann-Schwarz, Michael Friedlander, Orla McNally, Michael Quinn, et al.

Journal article  |  2012  |  CANCER RESEARCH

Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes

David J McBride, Dariush Etemadmoghadam, Susanna L Cooke, Kathryn Alsop, Joshy George, Adam Butler, Juok Cho, Danushka Galappaththige, Chris Greenman, Karen D Howarth, King W Lau, Charlotte K Ng, Keiran Raine, Jon Teague, David C Wedge, Xavier Caubit, Michael R Stratton, James D Brenton, Peter J Campbell, P Andrew Futreal, et al.

Journal article  |  2012  |  Journal of Pathology

BRCA Mutation Frequency and Patterns of Treatment Response in BRCA Mutation-Positive Women With Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group

Kathryn Alsop, Sian Fereday, Cliff Meldrum, Anna deFazio, Catherine Emmanuel, Joshy George, Alexander Dobrovic, Michael J Birrer, Penelope M Webb, Colin Stewart, Michael Friedlander, Stephen Fox, David Bowtell, Gillian Mitchell

Journal article  |  2012  |  JOURNAL OF CLINICAL ONCOLOGY

The Changing View of High-Grade Serous Ovarian Cancer

Els MJJ Berns, David D Bowtell

Journal article  |  2012  |  Cancer Research

MicroRNA Genes and Their Target 3 '-Untranslated Regions Are Infrequently Somatically Mutated in Ovarian Cancers

Georgina L Ryland, Jennifer L Bearfoot, Maria A Doyle, Samantha E Boyle, David YH Choong, Simone M Rowley, Richard W Tothill, Kylie L Gorringe, Ian G Campbell

Journal article  |  2012  |  PLoS One

Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy

Christina SF Wong, Jaclyn Sceneay, Colin M House, Heloise M Halse, Mira CP Liu, Joshy George, Titaina CU Potdevin Hunnam, Belinda S Parker, Izhak Haviv, Ze'ev Ronai, Carleen Cullinane, David D Bowtell, Andreas Moeller

Journal article  |  2012  |  Cancer Research

A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment

Hagen Kulbe, Probir Chakravarty, D Andrew Leinster, Kellie A Charles, Joseph Kwong, Richard G Thompson, Jermaine I Coward, Tiziana Schioppa, Stephen C Robinson, William M Gallagher, Laura Galletta, Michael A Salako, John F Smyth, Thorsten Hagemann, Donal J Brennan, David D Bowtell, Frances R Balkwill

Journal article  |  2012  |  CANCER RESEARCH

Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium

Jonine D Figueroa, Montserrat Garcia-Closas, Manjeet Humphreys, Radka Platte, John L Hopper, Melissa C Southey, Carmel Apicella, Fleur Hammet, Marjanka K Schmidt, Annegien Broeks, Rob AEM Tollenaar, Laura J Van't Veer, Peter A Fasching, Matthias W Beckmann, Arif B Ekici, Reiner Strick, Julian Peto, Isabel dos Santos Silva, Olivia Fletcher, Nichola Johnson, et al.

Journal article  |  2011  |  Human Molecular Genetics

Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia

Hyungsoo Kim, Maria C Scimia, Deepti Wilkinson, Ramon D Trelles, Malcolm R Wood, David Bowtell, Andrew Dillin, Mark Mercola, Ze'ev A Ronai

Journal article  |  2011  |  Molecular Cell

Rethinking ovarian cancer: recommendations for improving outcomes

Sebastian Vaughan, Jermaine I Coward, Robert C Bast, Andy Berchuck, Jonathan S Berek, James D Brenton, George Coukos, Christopher C Crum, Ronny Drapkin, Dariush Etemadmoghadam, Michael Friedlander, Hani Gabra, Stan B Kaye, Chris J Lord, Ernst Lengyel, Douglas A Levine, Iain A McNeish, Usha Menon, Gordon B Mills, Kenneth P Nephew, et al.

Journal article  |  2011  |  Nature Reviews Cancer

Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress

Yoshito Nagano, Toru Fukushima, Kazuo Okemoto, Keiichiro Tanaka, David DL Bowtell, Ze'ev A Ronai, John C Reed, Shu-ichi Matsuzawa

Journal article  |  2011  |  Cell Cycle

Identification of Novel Therapeutic Targets in Microdissected Clear Cell Ovarian Cancers

Michael P Stany, Vinod Vathipadiekal, Laurent Ozbun, Rebecca L Stone, Samuel C Mok, Hui Xue, Takashi Kagami, Yuwei Wang, Jessica N McAlpine, David Bowtell, Peter W Gout, Dianne M Miller, C Blake Gilks, David G Huntsman, Susan L Ellard, Yu-Zhuo Wang, Pablo Vivas-Mejia, Gabriel Lopez-Berestein, Anil K Sood, Michael J Birrer

Journal article  |  2011  |  PLoS ONE

Integrated genomic analyses of ovarian carcinoma

D Bell, A Berchuck, M Birrer, J Chien, DW Cramer, F Dao, R Dhir, P DiSaia, H Gabra, P Glenn, AK Godwin, J Gross, L Hartmann, M Huang, DG Huntsman, M Iacocca, M Imielinski, S Kalloger, BY Karlan, DA Levine, et al.

Journal article  |  2011  |  Nature

Reducing Time to Diagnosis Does Not Improve Outcomes for Women With Symptomatic Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group

Christina M Nagle, Jane E Francis, Anne E Nelson, Helen Zorbas, Karen Luxford, Anna de Fazio, Sian Fereday, David D Bowtell, Adele C Green, Penelope M Webb

Journal article  |  2011  |  Journal of Clinical Oncology

The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene

X Zhang, J George, S Deb, JL Degoutin, EA Takano, SB Fox, DDL Bowtell, KF Harvey

Journal article  |  2011  |  Oncogene

Role of Molecular Agents and Targeted Therapy in Clinical Trials for Women With Ovarian Cancer

Jonathan A Ledermann, Christian Marth, Mark S Carey, Michael Birrer, David DL Bowtell, Stan Kaye, Iain McNeish, Amit Oza, Giovanni Scambia, Gordon Rustin, Frederick B Stehman, David Gershenson, Gillian Thomas, Els Berns, Antonio Casado, Nelleke Ottevanger, Felix Hilpert, Byoung-Gie Kim, Aikou Okamoto, Monica Bacon, et al.

Journal article  |  2011  |  International Journal of Gynecologic Cancer

IL6-STAT3-HIF Signaling and Therapeutic Response to the Angiogenesis Inhibitor Sunitinib in Ovarian Clear Cell Cancer

Michael S Anglesio, Joshy George, Hagen Kulbe, Michael Friedlander, Danny Rischin, Charlotte Lemech, Jeremy Power, Jermaine Coward, Prue A Cowin, Colin M House, Probir Chakravarty, Kylie L Gorringe, Ian G Campbell, Aikou Okamoto, Michael J Birrer, David G Huntsman, Anna de Fazio, Steve E Kalloger, Frances Balkwill, C Blake Gilks, et al.

Journal article  |  2011  |  Clinical Cancer Research

Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers

Aslaug Helland, Michael S Anglesio, Joshy George, Prue A Cowin, Cameron N Johnstone, Colin M House, Karen E Sheppard, Dariush Etemadmoghadam, Nataliya Melnyk, Anil K Rustgi, Wayne A Phillips, Hilde Johnsen, Ruth Holm, Gunnar B Kristensen, Michael J Birrer, Richard B Pearson, Anne-Lise Borresen-Dale, David G Huntsman, Anna deFazio, Chad J Creighton, et al.

Journal article  |  2011  |  PLoS One

Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis

Catherine Emmanuel, Natalie Gava, Catherine Kennedy, Rosemary L Balleine, Raghwa Sharma, Gerard Wain, Alison Brand, Russell Hogg, Dariush Etemadmoghadam, Joshy George, Michael J Birrer, Christine L Clarke, Georgia Chenevix-Trench, David DL Bowtell, Paul R Harnett, Anna deFazio

Journal article  |  2011  |  PLoS One

A response to the forgotten fallopian tube

David DL Bowtell, Michael Friedlander, Michael Quinn, Gillian Mitchell

Journal article  |  2011  |  Nature Reviews Cancer

Precision Medicine: Dawn of Supercomputing in ‘omics Research

M Reumann, KE Holt, M Inouye, T Stinear, B Goudey, G Abraham, Q WANG, F Shi, A Kowalczyk, A Pearce, A Isaac, BJ Pope, H Butzkueven, J Wagner, S Moore, M Downton, PC Church, SJ Turner, J Field, M Southey, et al.

Conference Proceedings  |  2011  |  Proceedings of the 5th eResearch Australasia Conference

The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression

Peter Chan, Andreas Moeller, Mira CP Liu, Jaclyn E Sceneay, Christina SF Wong, Nic Waddell, Katie T Huang, Alexander Dobrovic, Ewan KA Millar, Sandra A O'Toole, Catriona M McNeil, Robert L Sutherland, David D Bowtell, Stephen B Fox

Journal article  |  2011  |  Breast Cancer Research

Amplicon-Dependent CCNE1 Expression Is Critical for Clonogenic Survival after Cisplatin Treatment and Is Correlated with 20q11 Gain in Ovarian Cancer

Dariush Etemadmoghadam, Joshy George, Prue A Cowin, Carleen Cullinane, Maya Kansara, Kylie L Gorringe, Gordon K Smyth, David DL Bowtell

Journal article  |  2010  |  PLoS One

The genesis and evolution of high-grade serous ovarian cancer

David DL Bowtell

Journal article  |  2010  |  Nature Reviews Cancer

ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas

Kimberly C Wiegand, Sohrab P Shah, Osama M Al-Agha, Yongjun Zhao, Kane Tse, Thomas Zeng, Janine Senz, Melissa K McConechy, Michael S Anglesio, Steve E Kalloger, Winnie Yang, Alireza Heravi-Moussavi, Ryan Giuliany, Christine Chow, John Fee, Abdalnasser Zayed, Leah Prentice, Nataliya Melnyk, Gulisa Turashvili, Allen D Delaney, et al.

Journal article  |  2010  |  New England Journal of Medicine

Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary

Ashour Ahmed Ahmed, Dariush Etemadmoghadam, Jillian Temple, Andy G Lynch, Mohamed Riad, Raghwa Sharma, Colin Stewart, Sian Fereday, Carlos Caldas, Anna DeFazio, David Bowtell, James D Brenton

Journal article  |  2010  |  Journal of Pathology

Siah Proteins: Novel Drug Targets in the Ras and Hypoxia Pathways

Colin M House, Andreas Moeller, David DL Bowtell

Journal article  |  2009  |  Cancer Research

Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer

Chia Huey Ooi, Tatiana Ivanova, Jeanie Wu, Minghui Lee, Iain Beehuat Tan, Jiong Tao, Lindsay Ward, Jun Hao Koo, Veena Gopalakrishnan, Yansong Zhu, Lai Ling Cheng, Julian Lee, Sun Young Rha, Hyun Cheol Chung, Kumaresan Ganesan, Jimmy So, Khee Chee Soo, Dennis Lim, Weng Hoong Chan, Wai Keong Wong, et al.

Journal article  |  2009  |  PLoS Genetics

Integrated Genome-Wide DNA Copy Number and Expression Analysis Identifies Distinct Mechanisms of Primary Chemoresistance in Ovarian Carcinomas

Dariush Etemadmoghadam, Anna deFazio, Rameen Beroukhim, Craig Mermel, Joshy George, Gad Getz, Richard Tothill, Aikou Okamoto, Maria B Raeder, Paul Harnett, Stephen Lade, Lars A Akslen, Anna V Tinker, Bianca Locandro, Kathryn Alsop, Yoke-Eng Chiew, Nadia Traficante, Sian Fereday, Daryl Johnson, Stephen Fox, et al.

Journal article  |  2009  |  Clinical Cancer Research

An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response

Marco A Calzado, Laureano de la Vega, Andreas Moeller, David DL Bowtell, M Lienhard Schmitz

Journal article  |  2009  |  Nature Cell Biology

Inhibition of Siah ubiquitin ligase function

A Moller, CM House, CSF Wong, DB Scanlon, MCP Liu, Z Ronai, DDL Bowtell

Journal article  |  2009  |  Oncogene

Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome

Richard W Tothill, Anna V Tinker, Joshy George, Robert Brown, Stephen B Fox, Stephen Lade, Daryl S Johnson, Melanie K Trivett, Dariush Etemadmoghadam, Bianca Locandro, Nadia Traficante, Sian Fereday, Jillian A Hung, Yoke-Eng Chiew, Lzhak Haviv, Dorota Gertig, Anna deFazio, David DL Bowtel

Journal article  |  2008  |  Clinical Cancer Research

Siah proteins induce the epidermal growth factor-dependent degradation of phospholipase C epsilon

Sanguk Yun, Andreas Moeller, Suhn-Kee Chae, Won-Pyo Hong, Young Ju Bae, David DL Bowtell, Sung Ho Ryu, Pann-Ghill Suh

Journal article  |  2008  |  Journal of Biological Chemistry

High resolution melting for mutation scanning of TP53 exons 5-8

Michael Krypuy, Ahmed Ashour Ahmed, Dariush Etemadmoghadam, Sarah J Hyland, Anna deFazio, Stephen B Fox, James D Brenton, David D Bowtell, Alexander Dobrovic

Journal article  |  2007  |  BMC CANCER

Genome-wide association study identifies novel breast cancer susceptibility loci

Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul DP Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben, Nicholas Wareham, Shahana Ahmed, Catherine S Healey, Richard Bowman, Kerstin B Meyer, Christopher A Haiman, Laurence K Kolonel, Brian E Henderson, Loic Le Marchand, Paul Brennan, et al.

Journal article  |  2007  |  Nature

A molecular diagnostic test for distinguishing lung adenocarcinoma from malignant mesothelioma using cells collected from pleural effusions

Andrew J Holloway, Dileepa S Diyagama, Ken Opeskin, Jenette Creaney, Bruce WS Robinson, Richard A Lake, David DL Bowtell

Journal article  |  2006  |  Clinical Cancer Research

The challenges of gene expression microarrays for the study of human cancer

Anna V Tinker, Alex Boussioutas, David DL Bowtell

Journal article  |  2006  |  Cancer Cell

Topological and functional discovery in a gene coexpression meta-network of gastric cancer

A Aggarwal, DL Guo, Y Hoshida, ST Yuen, KM Chu, S So, A Boussioutas, X Chen, D Bowtell, H Aburatani, SY Leung, P Tan

Journal article  |  2006  |  Cancer Research

An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin

RW Tothill, A Kowalczyk, D Rischin, A Bousioutas, I Haviv, RK van Laar, PM Waring, J Zalcberg, R Ward, AV Biankin, RL Sutherland, SM Henshall, K Fong, JR Pollack, DDL Bowtell, AJ Holloway

Journal article  |  2005  |  Cancer Research

Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization

KL Gorringe, A Boussioutas, DDL Bowtell

Journal article  |  2005  |  Genes, Chromosomes & Cancer

Generation and analysis of Siah2 mutant mice.

Ian J Frew, Vicki E Hammond, Ross A Dickins, Julian MW Quinn, Carl R Walkley, Natalie A Sims, Ralf Schnall, Neil G Della, Andrew J Holloway, Matthew R Digby, Peter W Janes, David M Tarlinton, Louise E Purton, Matthew T Gillespie, David DL Bowtell

Journal article  |  2003  |  Molecular and Cellular Biology

Siah proteins function as E3 ubiquitin ligase enzymes to target the degradation of diverse protein substrates. To characterize the..

The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice

RA Dickins, IJ Frew, CM House, MK O'Bryan, AJ Holloway, I Haviv, N Traficante, DM de Kretser, DDL Bowtell

Journal article  |  2002  |  Molecular and Cellular Biology