David Bowtell

CCNE1 Amplification as a Therapeutic Target.

George Au-Yeung, Linda Mileshkin, David DL Bowtell

Journal article  |  2023  |  J Clin Oncol

Multiomic analysis of homologous recombination-deficient end-stage high-grade serous ovarian cancer.

Nikki L Burdett, Madelynne O Willis, Kathryn Alsop, Allison L Hunt, Ahwan Pandey, Phineas T Hamilton, Tamara Abulez, Xuan Liu, Therese Hoang, Stuart Craig, Sian Fereday, Joy Hendley, Dale W Garsed, Katy Milne, Shreena Kalaria, Ashley Marshall, Brian L Hood, Katlin N Wilson, Kelly A Conrads, Kathleen I Pishas, et al.

Journal article  |  2023  |  Nat Genet

High-grade serous ovarian cancer (HGSC) is frequently characterized by homologous recombination (HR) DNA repair deficiency and, wh..

Older age should not be a barrier to testing for somatic variants in homologous recombination DNA repair-related genes in patients with high-grade serous ovarian carcinoma.

Omali Pitiyarachchi, Yeh Chen Lee, Hao-Wen Sim, Sivatharsny Srirangan, Cristina Mapagu, Judy Kirk, Paul R Harnett, Rosemary L Balleine, David DL Bowtell, Goli Samimi, Alison H Brand, Deborah J Marsh, Philip Beale, Lyndal Anderson, Natalie Bouantoun, Pamela Provan, undefined INOVATe Investigators, Susan J Ramus, Anna DeFazio, Michael Friedlander

Journal article  |  2023  |  Transl Oncol

BACKGROUND: Somatic pathogenic variants (PVs) in homologous recombination DNA repair (HR)-related genes found in high-grade serous..

Methylation Signature Implicated in Immuno-Suppressive Activities in Tubo-Ovarian High-Grade Serous Carcinoma.

Chen Wang, Matthew S Block, Julie M Cunningham, Mark E Sherman, Bryan M McCauley, Sebastian M Armasu, Robert A Vierkant, Nadia Traficante, undefined Australian Ovarian Cancer Study Group, Aline Talhouk, Susan J Ramus, Nadja Pejovic, Martin Köbel, Brooke D Jorgensen, Dale W Garsed, Sian Fereday, Jennifer A Doherty, Dinuka Ariyaratne, Michael S Anglesio, Martin Widschwendter, et al.

Journal article  |  2023  |  Cancer Epidemiol Biomarkers Prev

BACKGROUND: Better understanding of prognostic factors in tubo-ovarian high-grade serous carcinoma (HGSC) is critical, as diagnosi..

A qualitative study of patients with Cancer of Unknown Primary: Perceptions of communication, understanding of diagnosis and genomic testing, and information needs

Kamil Wolyniec, Clare O'Callaghan, Krista Fisher, Sharp Jessica, Richard WW Tothill, David Bowtell, Mileshkin Linda, Penelope Schofield

Journal article  |  2023  |  PSYCHO-ONCOLOGY

OBJECTIVE: Patients with Cancer of Unknown Primary (CUP) commonly report poor understanding of their illness and high levels of ps..

Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.

Ashley Weir, Eun-Young Kang, Nicola S Meagher, Gregg S Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J Riggan, Aleksandra Gentry-Maharaj, Andy Ryan, Naveena Singh, Martin Widschwendter, Jennifer Alsop, Michael S Anglesio, Matthias W Beckmann, Jessica Berger, Christiani Bisinotto, Jessica Boros, Alison H Brand, James D Brenton, Angela Brooks-Wilson, et al.

Journal article  |  2023  |  Br J Cancer

BACKGROUND: Recently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (H..

The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

Moritz Gerstung, Clemency Jolly, Ignaty Leshchiner, Stefan C Dentro, Santiago Gonzalez, Daniel Rosebrock, Thomas J Mitchell, Yulia Rubanova, Pavana Anur, Kaixian Yu, Maxime Tarabichi, Amit Deshwar, Jeff Wintersinger, Kortine Kleinheinz, Ignacio Vazquez-Garcia, Kerstin Haase, Lara Jerman, Subhajit Sengupta, Geoff Macintyre, Salem Malikic, et al.

Journal article  |  2023  |  NATURE

Profiling the immune landscape in mucinous ovarian carcinoma.

Nicola S Meagher, Phineas Hamilton, Katy Milne, Shelby Thornton, Bronwyn Harris, Ashley Weir, Jennifer Alsop, Christiani Bisinoto, James D Brenton, Angela Brooks-Wilson, Derek S Chiu, Kara L Cushing-Haugen, Sian Fereday, Dale W Garsed, Simon A Gayther, Aleksandra Gentry-Maharaj, Blake Gilks, Mercedes Jimenez-Linan, Catherine J Kennedy, Nhu D Le, et al.

Journal article  |  2023  |  Gynecol Oncol

OBJECTIVE: Mucinous ovarian carcinoma (MOC) is a rare histotype of ovarian cancer, with low response rates to standard chemotherap..

Contrasting clinical characteristics and treatment patterns in women with newly diagnosed advanced-stage epithelial ovarian cancer in Australia, South Korea and Taiwan

Hung-Hsueh Chou, Sian Fereday, Anna DeFazio, Chih-Long Chang, David Bowtell, Heng-Cheng Hsu, Nadia Traficante, Soo Young Jeong, Wen-Fang Cheng, Dinuka Ariyarantne, Teresa Tung, Viraj Rajadhyaksha, Won-Hee Lee, David Brown, Byoung-Gie Kim

Journal article  |  2023  |  JOURNAL OF GYNECOLOGIC ONCOLOGY

OBJECTIVE: The real-world INFORM study analyzed sociodemographics, treatment patterns and clinical outcomes for patients with newl..

Immune and genomic biomarkers of immunotherapy response in cancer of unknown primary

Atara Posner, Tharani Sivakumaran, Andrew Pattison, Dariush Etemadmoghadam, Niko Thio, Colin Wood, Krista Fisher, Samantha Webb, Anna DeFazio, Nicholas Wilcken, Bo Gao, Christos S Karapetis, Madhu Singh, Ian M Collins, Gary Richardson, Christopher Steer, Mark Warren, Narayan Karanth, Andrew Fellowes, Stephen B Fox, et al.

Journal article  |  2023  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

BACKGROUND: Cancer of unknown primary (CUP) is a heterogeneous group of metastatic cancers where a primary tissue of origin (TOO) ..