Joseph Trapani

Myeloma natural killer cells are exhausted and have impaired regulation of activation

Criselle D'Souza, Simon P Keam, Han Xian Aw Yeang, Michael Neeson, Kelden Richardson, Andy K Hsu, Rachael Canfield, Natalie Bezman, Michael Robbins, Hang Quach, David S Ritchie, Simon J Harrison, Joseph A Trapani, H Miles Prince, Paul A Beavis, Phillip K Darcy, Paul J Neeson

Journal article  |  2021  |  HAEMATOLOGICA

Not available.

Single-Fraction vs Multifraction Stereotactic Ablative Body Radiotherapy for Pulmonary Oligometastases (SAFRON II) The Trans Tasman Radiation Oncology Group 13.01 Phase 2 Randomized Clinical Trial

Shankar Siva, Mathias Bressel, Tao Mai, Hien Le, Shalini Vinod, Harini de Silva, Sean Macdonald, Marketa Skala, Nicholas Hardcastle, Angela Rezo, David Pryor, Suki Gill, Braden Higgs, Kassandra Wagenfuehr, Rebecca Montgomery, Raef Awad, Brent Chesson, Thomas Eade, Wenchang Wong, Giuseppe Sasso, et al.

Journal article  |  2021  |  JAMA ONCOLOGY

Importance: Evidence is lacking from randomized clinical trials to guide the optimal approach for stereotactic ablative body radio..

Early-phenotype CAR-T cells for the treatment of pediatric cancers.

D Meyran, R Terry, JJ Zhu, M Haber, DS Ziegler, P Ekert, JA Trapani, PK Darcy, PJ Neeson

Journal article  |  2021  |  Ann Oncol

Chimeric antigen receptor (CAR) T cell therapy is a promising approach for the treatment of childhood cancers, particularly high-r..

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

Mohamed Fareh, Wei Zhao, Wenxin Hu, Joshua ML Casan, Amit Kumar, Jori Symons, Jennifer M Zerbato, Danielle Fong, Ilia Voskoboinik, Paul G Ekert, Rajeev Rudraraju, Damian FJ Purcell, Sharon R Lewin, Joseph A Trapani

Journal article  |  2021  |  NATURE COMMUNICATIONS

The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approa..

Abstract 3044: The unexplored immune landscape of high-risk pediatric cancers

Chelsea Mayoh, Rachael L Terry, Marie Wong, Loretta M Lau, Dong Anh Khuong-Quang, Marion K Mateos, Vanessa Tyrrell, Michelle Haber, David S Ziegler, Mark J Cowley, Joseph A Trapani, Paul J Neeson, Paul G Ekert

Conference Proceedings  |  2021  |  Tumor Biology

The unexplored immune landscape of high-risk pediatric cancers.

Chelsea Mayoh, Rachael L Terry, Marie Wong, Loretta M Lau, Dong Anh Khuong-Quang, Marion K Mateos, Vanessa Tyrrell, Michelle Haber, David S Ziegler, Mark J Cowley, Joseph A Trapani, Paul J Neeson, Paul G Ekert

Conference Proceedings  |  2021  |  CANCER RESEARCH

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Nicolas Jacquelot, Cyril Seillet, Minyu Wang, Angela Pizzolla, Yang Liao, Soroor Hediyeh-zadeh, Sharon Grisaru-Tal, Cynthia Louis, Qiutong Huang, Jaring Schreuder, Fernando Souza-Fonseca-Guimaraes, Carolyn A de Graaf, Kevin Thia, Sean Macdonald, Mary Camilleri, Kylie Luong, Shengbo Zhang, Michael Chopin, Tristan Molden-Hauer, Stephen L Nutt, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigen..

Antigen-driven EGR2 expression is required for exhausted CD8( ) T cell stability and maintenance

Mayura Wagle, Stephin J Vervoort, Madison J Kelly, Willem Van der Byl, Timothy J Peters, Ben P Martin, Luciano G Martelotto, Simone Nuessing, Kelly M Ramsbottom, James R Torpy, Deborah Knight, Sinead Reading, Kevin Thia, Lisa A Miosge, Debbie R Howard, Renee Gloury, Sarah S Gabriel, Daniel T Utzschneider, Jane Oliaro, Jonathan D Powell, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Chronic stimulation of CD8+ T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhau..

Preclinical Evidence of the Efficacy of Lewis Y Car T Cells in Patient-Derived Models of Prostate Cancer

Gail Petuna Risbridger, Laura Helen Porter, Joe Zhu, David Byrne, Natalie Lister, Arun Azad, Michael Hofman, Ian Vela, Renea A Taylor, Paul Neeson, Phil Darcy, Joseph Trapani

Conference Proceedings  |  2021  |  Journal of the Endocrine Society

Abstract Chimeric antigen receptor T (CAR T) cell therapy is an adoptive immunotherapy that has led to new treatmen..

Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer

Amelie Cachot, Mariia Bilous, Yen-Cheng Liu, Xiaokang Li, Margaux Saillard, Mara Cenerenti, Georg Alexander Rockinger, Tania Wyss, Philippe Guillaume, Julien Schmidt, Raphael Genolet, Giuseppe Ercolano, Maria Pia Protti, Walter Reith, Kalliopi Ioannidou, Laurence de Leval, Joseph A Trapani, George Coukos, Alexandre Harari, Daniel E Speiser, et al.

Journal article  |  2021  |  SCIENCE ADVANCES

CD4 T cells have been implicated in cancer immunity for their helper functions. Moreover, their direct cytotoxic potential has bee..