Joseph Trapani

Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion

Florida Voli, Emanuele Valli, Luigi Lerra, Kathleen Kimpton, Federica Saletta, Federico M Giorgi, Daniele Mercatelli, Jourdin RC Rouaen, Sylvie Shen, Jayne E Murray, Aria Ahmed-Cox, Giuseppe Cirillo, Chelsea Mayoh, Paul A Beavis, Michelle Haber, Joseph A Trapani, Maria Kavallaris, Orazio Vittorio

Journal article  |  2020  |  Cancer Research

Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically ..

Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus

Vivien R Sutton, Christopher Andoniou, Michael G Leeming, Colin M House, Sally Watt, Sandra Verschoor, Annette Ciccone, Ilia Voskoboinik, Mariapia Degli-Esposti, Joseph A Trapani

Journal article  |  2020  |  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

We investigated the molecular basis for the remarkably different survival outcomes of mice expressing different alloforms of the p..

Challenges of PD-L1 testing in non-small cell lung cancer and beyond & nbsp;

Minyu Wang, Sen Wang, Joseph A Trapani, Paul J Neeson

Journal article  |  2020  |  Journal of Thoracic Disease

ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome

Melody Cheong, Kate H Gartlan, Jason S Lee, Siok-Keen Tey, Ping Zhang, Rachel D Kuns, Christopher E Andoniou, Jose Paulo Martins, Karshing Chang, Vivien R Sutton, Greg Kelly, Antiopi Varelias, Slavica Vuckovic, Kate A Markey, Glen M Boyle, Mark J Smyth, Christian R Engwerda, Kelli PA MacDonald, Joseph A Trapani, Mariapia A Degli-Esposti, et al.

Journal article  |  2020  |  Cancer Immunology Research

The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, w..

Immune profiling of pediatric solid tumors

Rachael L Terry, Deborah Meyran, David S Ziegler, Michelle Haber, Paul G Ekert, Joseph A Trapani, Paul J Neeson

Journal article  |  2020  |  Journal of Clinical Investigation

Pediatric cancers, particularly high-risk solid tumors, urgently need effective and specific therapies. Their outlook has not appr..

Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity

Junyun Lai, Sherly Mardiana, Imran G House, Kevin Sek, Melissa A Henderson, Lauren Giuffrida, Amanda XY Chen, Kirsten L Todd, Emma Petley, Jack D Chan, Emma M Carrington, Andrew M Lew, Benjamin J Solomon, Joseph A Trapani, Katherine Kedzierska, Maximilien Evrard, Stephin J Vervoort, Jason Waithman, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  Nature Immunology

Adoptive cell therapies using genetically engineered T cell receptor or chimeric antigen receptor T cells are emerging forms of im..

Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis

Helena S Jang, Thijs WH Flinsenberg, Paul Lacaze, Kevin YT Thia, Tahereh Noori, Suran L Fernando, Ian Kerridge, Moeen Riaz, John J McNeil, Piers A Blombery, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2020  |  British Journal of Haematology

Cross-talk between tumors at anatomically distinct sites

Amanda J Oliver, Phillip K Darcy, Joseph A Trapani, Michael H Kershaw, Clare Y Slaney

Journal article  |  2020  |  The FEBS Journal

Cancer tissue is not homogenous, and individual metastases at different anatomical locations can differ from the primary tumor and..

Efficient CRISPR/Cas9 Gene Editing in Uncultured Naive Mouse T Cells for In Vivo Studies

Simone Nussing, Imran G House, Conor J Kearney, Amanda XY Chen, Stephin J Vervoort, Paul A Beavis, Jane Oliaro, Ricky W Johnstone, Joseph A Trapani, Ian A Parish

Journal article  |  2020  |  The Journal of Immunology

CRISPR/Cas9 technologies have revolutionized our understanding of gene function in complex biological settings, including T cell i..

Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo

Julie A Spicer, Christian K Miller, Patrick D O'Connor, Jiney Jose, Anna C Giddens, Jagdish K Jaiswal, Stephen MF Jamieson, Matthew R Bull, William A Denny, Hedieh Akhlaghi, Joseph A Trapani, Geoff R Hill, Karshing Chang, Kate H Gartlan

Journal article  |  2020  |  Journal of Medicinal Chemistry

Perforin is a key effector protein in the vertebrate immune system and is secreted by cytotoxic T lymphocytes and natural killer c..