Joseph Trapani

Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus

Vivien R Sutton, Christopher Andoniou, Michael G Leeming, Colin M House, Sally Watt, Sandra Verschoor, Annette Ciccone, Ilia Voskoboinik, Mariapia Degli-Esposti, Joseph A Trapani

Journal article  |  2020  |  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

We investigated the molecular basis for the remarkably different survival outcomes of mice expressing different alloforms of the p..

Immune profiling of pediatric solid tumors.

Rachael L Terry, Deborah Meyran, David S Ziegler, Michelle Haber, Paul G Ekert, Joseph A Trapani, Paul J Neeson

Journal article  |  2020  |  Journal of Clinical Investigation

Pediatric cancers, particularly high-risk solid tumors, urgently need effective and specific therapies. Their outlook has not appr..

ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome.

Melody Cheong, Kate H Gartlan, Jason S Lee, Siok-Keen Tey, Ping Zhang, Rachel D Kuns, Christopher E Andoniou, Jose Paulo Martins, Karshing Chang, Vivien R Sutton, Greg Kelly, Antiopi Varelias, Slavica Vuckovic, Kate A Markey, Glen M Boyle, Mark J Smyth, Christian R Engwerda, Kelli PA MacDonald, Joseph A Trapani, Mariapia A Degli-Esposti, et al.

Journal article  |  2020  |  Cancer Immunology Research

The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, w..

Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity

Junyun Lai, Sherly Mardiana, Imran G House, Kevin Sek, Melissa A Henderson, Lauren Giuffrida, Amanda XY Chen, Kirsten L Todd, Emma Petley, Jack D Chan, Emma M Carrington, Andrew M Lew, Benjamin J Solomon, Joseph A Trapani, Katherine Kedzierska, Maximilien Evrard, Stephin J Vervoort, Jason Waithman, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  Nature Immunology

Adoptive cell therapies using genetically engineered T cell receptor or chimeric antigen receptor T cells are emerging forms of im..

Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis

Helena S Jang, Thijs WH Flinsenberg, Paul Lacaze, Kevin YT Thia, Tahereh Noori, Suran L Fernando, Ian Kerridge, Moeen Riaz, John J McNeil, Piers A Blombery, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2020  |  British Journal of Haematology

Cross-talk between tumors at anatomically distinct sites

Amanda J Oliver, Phillip K Darcy, Joseph A Trapani, Michael H Kershaw, Clare Y Slaney

Journal article  |  2020  |  The FEBS Journal

Cancer tissue is not homogenous, and individual metastases at different anatomical locations can differ from the primary tumor and..

Efficient CRISPR/Cas9 Gene Editing in Uncultured Naive Mouse T Cells for In Vivo Studies

Simone Nussing, Imran G House, Conor J Kearney, Amanda XY Chen, Stephin J Vervoort, Paul A Beavis, Jane Oliaro, Ricky W Johnstone, Joseph A Trapani, Ian A Parish

Journal article  |  2020  |  The Journal of Immunology

CRISPR/Cas9 technologies have revolutionized our understanding of gene function in complex biological settings, including T cell i..

Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo

Julie A Spicer, Christian K Miller, Patrick D O'Connor, Jiney Jose, Anna C Giddens, Jagdish K Jaiswal, Stephen MF Jamieson, Matthew R Bull, William A Denny, Hedieh Akhlaghi, Joseph A Trapani, Geoff R Hill, Karshing Chang, Kate H Gartlan

Journal article  |  2020  |  Journal of Medicinal Chemistry

Perforin is a key effector protein in the vertebrate immune system and is secreted by cytotoxic T lymphocytes and natural killer c..

Prevalence and disease predisposition of p.A91V perforin in an aged population of European ancestry

Ilia Voskoboinik, Paul Lacaze, Helena Sung-In Jang, Thijs Flinsenberg, Suran L Fernando, Ian Kerridge, Moeen Riaz, Robert Sebra, Kevin Thia, Taherah Noori, Eric E Schadt, John J McNeil, Joseph A Trapani

Journal article  |  2020  |  Blood

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma

Thijs WH Flinsenberg, Charnelle C Tromedjo, Nan Hu, Ye Liu, Yin Guo, Kevin YT Thia, Tahereh Noori, Xiaomin Song, Han X Aw Yeang, Daniela G Tantalo, Sasanka Handunnetti, John F Seymour, Andrew W Roberts, David Ritchie, Rachel Koldej, Paul J Neeson, Lai Wang, Joseph A Trapani, Constantine S Tam, Ilia Voskoboinik

Journal article  |  2020  |  Haematologica

Enhancing chimeric antigen receptor T-cell immunotherapy against cancer using a nanoemulsion-based vaccine targeting cross-presenting dendritic cells.

Jack D Chan, Bianca von Scheidt, Bijun Zeng, Amanda J Oliver, Ashleigh S Davey, Aesha I Ali, Ranjeny Thomas, Joseph A Trapani, Phillip K Darcy, Michael H Kershaw, Riccardo Dolcetti, Clare Y Slaney

Journal article  |  2020  |  Clinical & Translational Immunology

Objectives: Adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is a form of cancer immunotherapy that has achie..

Lipid order and charge protect killer T cells from accidental death

Jesse A Rudd-Schmidt, Adrian W Hodel, Tahereh Noori, Jamie A Lopez, Hyun-Jung Cho, Sandra Verschoor, Annette Ciccone, Joseph A Trapani, Bart W Hoogenboom, Ilia Voskoboinik

Journal article  |  2019  |  NATURE COMMUNICATIONS

Killer T cells (cytotoxic T lymphocytes, CTLs) maintain immune homoeostasis by eliminating virus-infected and cancerous cells. CTL..

THE MANY FACES OF FAMILIAL HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS

Ilia Voskoboinik, Paul Gray, Stephen Opat, Andrew Grigg, Anthony Jaworowski, Joseph Trapani

Conference Proceedings  |  2019  |  INTERNAL MEDICINE JOURNAL

Antigen-specific CD4( )CD25( ) T cells induced by locally expressed ICOS-Ig: the role of Foxp3, Perforin, Granzyme B and IL-10-an experimental study

Dale Christiansen, Effie Mouhtouris, Russell Hodgson, Vivien R Sutto, Joseph A Trapani, Francesco L Ierino, Mauro S Sandrin

Journal article  |  2019  |  Transplant International

We have previously reported that ICOS-Ig expressed locally by a PIEC xenograft induces a perigraft cellular accumulation of CD4+ C..

DEVELOPMENT OF NEXT GENERATION CAR'S TARGETING THE LEWIS Y ANTIGEN FOR THE TREATMENT OF CANCER

D Meyran, J Zhu, J Buttler, D Tantalo, M Neeson, P Ekert, M Kershaw, J Trapani, P Darcy, P Neeson

Conference Proceedings  |  2019  |  Cytotherapy

Development of inhibitors of the pore forming protein perforin for the treatment of leukaemia

Jiney Jose, Julie Spicer, Christian Miller, Patrick O'Connor, Anna Giddens, Hediah Akhlaghi, Joseph Trapani, William Denny

Conference Proceedings  |  2019  |  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

Distinguishing perforin-mediated lysis and granzyme-dependent apoptosis

Jesse A Rudd-Schmidt, Joseph A Trapani, Ilia Voskoboinik

Book Chapter  |  2019  |  Methods in Enzymology

Perforin is an indispensable effector protein of primary cytotoxic lymphocytes (CTL or NK cells) that typically defend the host ag..

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

M Welz, S Eickhoff, Z Abdullah, J Trebicka, KH Gartlan, JA Spicer, AJ Demetris, H Akhlaghi, M Anton, K Manske, D Zehn, B Nieswandt, C Kurts, JA Trapani, P Knolle, D Wohlleber, W Kastenmueller

Journal article  |  2018  |  Nature Communications

CD8 T Cell-Mediated Endothelial Damage Drives Liver Failure during Viral Hepatitis

Percy Knolle, Dirk Wohlleber, Wolfgang Kastenmueller, Joseph Trapani

Conference Proceedings  |  2018  |  HEPATOLOGY

Dual PD-1 and CTLA-4 Checkpoint Blockade Promotes Antitumor Immune Responses through CD4( )Foxp3(-) Cell-Mediated Modulation of CD103( ) Dendritic Cells

Paul A Beavis, Melissa A Henderson, Lauren Giuffrida, Alexander J Davenport, Emma V Petley, Imran G House, Junyun Lai, Kevin Sek, Nicole Milenkovski, Liza B John, Sherly Mardiana, Clare Y Slaney, Joseph A Trapani, Sherene Loi, Michael H Kershaw, Nicole M Haynes, Phillip K Darcy

Journal article  |  2018  |  Cancer Immunology Research

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin

Amelia J Brennan, Ruby HP Law, Paul J Conroy, Tahereh Noori, Natalya Lukoyanova, Helen Saibil, Hideo Yagita, Annette Ciccone, Sandra Verschoor, James C Whisstock, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2018  |  Cell Death & Differentiation

Tumor immune evasion arises through loss of TNF sensitivity

Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien Sutton, Paul A Beavis, Ilia Voskoboinik, Phil K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro

Journal article  |  2018  |  Science Immunology

Down-regulation of a pro-apoptotic pathway regulated by PCAF/ADA3 in early stage gastric cancer

Daniella Brasacchio, Rita A Busuttil, Tahereh Noori, Ricky W Johnstone, Alex Boussioutas, Joseph A Trapani

Journal article  |  2018  |  Cell Death & Disease

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing

Jamie A Lopez, Tahereh Noori, Adrian Minson, Lu Li Jovanoska, Kevin Thia, Michael S Hildebrand, Hedieh Akhlaghi, Phillip K Darcy, Michael H Kershaw, Natasha J Brown, Andrew Grigg, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2018  |  FRONTIERS IN IMMUNOLOGY

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

AJ Davenport, RS Cross, KA Watson, Y Liao, W Shi, HM Prince, PA Beavis, JA Trapani, MH Kershaw, DS Ritchie, PK Darcy, PJ Neeson, MR Jenkins

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Adaptive reprogramming of NK cells in X-linked lymphoproliferative syndrome

Stephen Opat, Anna C Hearps, Kevin Thia, Agnes Yuen, Ben Rogers, Mkunde Chachage, Gregory Moore, Jake Shortt, Georgina Ryland, Piers Blombery, Anthony P Schwarer, Tahereh Noori, Joseph A Trapani, Anthony Jaworowski, Ilia Voskoboinik

Journal article  |  2018  |  Blood

Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation

Imran G House, Colin M House, Amelia J Brennan, Omer Gilan, Mark A Dawson, James C Whisstock, Ruby HP Law, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2017  |  EMBO reports

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

Sathana Dushyanthen, Zhi Ling Teo, Franco Caramia, Peter Savas, Christopher P Mintoff, Balaji Virassamy, Melissa A Henderson, Stephen J Luen, Mariam Mansour, Michael H Kershaw, Joseph A Trapani, Paul J Neeson, Roberto Salgado, Grant A McArthur, Justin M Balko, Paul A Beavis, Phillip K Darcy, Sherene Loi

Journal article  |  2017  |  Nature Communications

Substituted arylsulphonamides as inhibitors of perforin-mediated lysis

Julie A Spicer, Christian K Miller, Patrick D O'Connor, Jiney Jose, Kristiina M Huttunen, Jagdish K Jaiswal, William A Denny, Hedieh Akhlaghi, Kylie A Browne, Joseph A Trapani

Journal article  |  2017  |  European Journal of Medicinal Chemistry

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Marian L Burr, Christina E Sparbier, Yih-Chih Chan, James C Williamson, Katherine Woods, Paul A Beavis, Enid YN Lam, Melissa A Henderson, Charles C Bell, Sabine Stolzenburg, Omer Gilan, Stuart Bloor, Tahereh Noori, David W Morgens, Michael C Bassik, Paul J Neeson, Andreas Behren, Phillip K Darcy, Sarah-Jane Dawson, Ilia Voskoboinik, et al.

Journal article  |  2017  |  Nature

Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D

Paul Edgar Gray, Bella Shadur, Susan Russell, Richard Mitchell, Michael Buckley, Kerri Gallagher, Ian Andrews, Kevin Thia, Joseph A Trapani, Edwin Philip Kirk, Ilia Voskoboinik

Journal article  |  2017  |  Frontiers in Immunology

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

Daniella Brasacchio, Amber E Alsop, Tahereh Noori, Mariam Lufti, Sweta Iyer, Kaylene J Simpson, Phillip I Bird, Ruth M Kluck, Ricky W Johnstone, Joseph A Trapani

Journal article  |  2017  |  Cell Death & Differentiation

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2( ) Tumors

Mikolaj Medon, Eva Vidacs, Stephin J Vervoort, Jason Li, Misty R Jenkins, Kelly M Ramsbottom, Joseph A Trapani, Mark J Smyth, Phillip K Darcy, Peter W Atadja, Michael A Henderson, Ricky W Johnstone, Nicole M Haynes

Journal article  |  2017  |  Cancer Research

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Clare Y Slaney, Bianca von Scheidt, Alexander J Davenport, Paul A Beavis, Jennifer A Westwood, Sherly Mardiana, David C Tscharke, Sarah Ellis, H Miles Prince, Joseph A Trapani, Ricky W Johnstone, Mark J Smyth, Michele W Teng, Aesha Ali, Zhiya Yu, Steven A Rosenberg, Nicholas P Restifo, Paul Neeson, Phillip K Darcy, Michael H Kershaw

Journal article  |  2017  |  Clinical Cancer Research

Real-time visualization of perforin nanopore assembly

Carl Leung, Adrian W Hodel, Amelia J Brennan, Natalya Lukoyanova, Sharon Tran, Colin M House, Stephanie C Kondos, James C Whisstock, Michelle A Dunstone, Joseph A Trapani, Ilia Voskoboinik, Helen R Saibil, Bart W Hoogenboom

Journal article  |  2017  |  Nature Nanotechnology

Immunotherapy of cancer

Joseph A Trapani, Phillip K Darcy

Journal article  |  2017  |  AUSTRALIAN FAMILY PHYSICIAN

A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells

Sherly Mardiana, Liza B John, Melissa A Henderson, Clare Y Slaney, Bianca von Scheidt, Lauren Giuffrida, Alexander J Davenport, Joseph A Trapani, Paul J Neeson, Sherene Loi, Nicole M Haynes, Michael H Kershaw, Paul A Beavis, Phillip K Darcy

Journal article  |  2017  |  Cancer Research

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

Paul A Beavis, Melissa A Henderson, Lauren Giuffrida, Jane K Mills, Kevin Sek, Ryan S Cross, Alexander J Davenport, Liza B John, Sherly Mardiana, Clare Y Slaney, Ricky W Johnstone, Joseph A Trapani, John Stagg, Sherene Loi, Lev Kats, David Gyorki, Michael H Kershaw, Phillip K Darcy

Journal article  |  2017  |  Journal of Clinical Investigation

Benzenesulphonamide inhibitors of the cytolytic protein perforin

Julie A Spicer, Christian K Miller, Patrick D O'Connor, Jiney Jose, Kristiina M Huttunen, Jagdish K Jaiswal, William A Denny, Hedieh Akhlaghi, Kylie A Browne, Joseph A Trapani

Journal article  |  2017  |  Bioorganic & Medicinal Chemistry Letters

Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C

Lucy C Sullivan, Richard Berry, Natasha Sosnin, Jacqueline ML Widjaja, Felix A Deuss, Gautham R Balaji, Nicole L LaGruta, Michiko Mirams, Joseph A Trapani, Jamie Rossjohn, Andrew G Brooks, Daniel M Andrews

Journal article  |  2016  |  Journal of Biological Chemistry

A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity

KJ Falkenberg, A Newbold, CM Gould, J Luu, JA Trapani, GM Matthews, KJ Simpson, RW Johnstone

Journal article  |  2016  |  Cell Death & Differentiation

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer

Carmen SM Yong, Liza B John, Christel Devaud, Miles H Prince, Ricky W Johnstone, Joseph A Trapani, Phillip K Darcy, Michael H Kershaw

Journal article  |  2016  |  ONCOTARGET

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity

Vivien R Sutton, Amelia J Brennan, Sarah Ellis, Jill Danne, Kevin Thia, Misty R Jenkins, Ilia Voskoboinik, Gunnar Pejler, Ricky W Johnstone, Daniel M Andrews, Joseph A Trapani

Journal article  |  2016  |  FEBS Journal

Diarylthiophenes as inhibitors of the pore-forming protein perforin

Christian K Miller, Kristiina M Huttunen, William A Denny, Jagdish K Jaiswal, Annette Ciccone, Kylie A Browne, Joseph A Trapani, Julie A Spicer

Journal article  |  2016  |  Bioorganic & Medicinal Chemistry Letters

Missense mutations in the perforin (PRF1) gene as a cause of hereditary cancer predisposition

Mohammed S Chaudhry, Kimberly C Gilmour, Imran G House, Mark Layton, Nicki Panoskaltsis, Mamta Sohal, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2016  |  OncoImmunology

In memoriam: Prof Christopher J Froelich (1951-2015)

SS Metkar, J Pardo, G Anderluh, G Salvesen, JA Trapani, MM Simon

Journal article  |  2016  |  Cell Death & Differentiation

Analysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding

Sarah E Stewart, Catherina H Bird, Rico F Tabor, Michael E D'Angelo, Stefania Piantavigna, James C Whisstock, Joseph A Trapani, Lisandra L Martin, Phillip I Bird

Journal article  |  2015  |  Journal of Biological Chemistry

The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents

MR Bull, JA Spicer, KM Huttunen, WA Denny, A Ciccone, KA Browne, JA Trapani, NA Helsby

Journal article  |  2015  |  European Journal of Drug Metabolism and Pharmacokinetics

Structural Basis for Ca2 -mediated Interaction of the Perforin C2 Domain with Lipid Membranes

Hiromasa Yagi, Paul J Conroy, Eleanor WW Leung, Ruby HP Law, Joseph A Trapani, Ilia Voskoboinik, James C Whisstock, Raymond S Norton

Journal article  |  2015  |  Journal of Biological Chemistry

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals

Imran G House, Kevin Thia, Amelia J Brennan, Richard Tothill, Alexander Dobrovic, Wei Z Yeh, Richard Saffery, Zac Chatterton, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2015  |  Immunology & Cell Biology

B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis

Magdalena Hagn, Archana Panikkar, Corey Smith, Henry H Balfour, Rajiv Khanna, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2015  |  Clinical & Translational Immunology

Perforin and granzymes: function, dysfunction and human pathology

Ilia Voskoboinik, James C Whisstock, Joseph A Trapani

Journal article  |  2015  |  Nature Reviews Immunology

CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells

Alexander J Davenport, Misty R Jenkins, Ryan S Cross, Carmen S Yong, H Miles Prince, David S Ritchie, Joseph A Trapani, Michael H Kershaw, Phillip K Darcy, Paul J Neeson

Journal article  |  2015  |  CANCER IMMUNOLOGY RESEARCH

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

Misty R Jenkins, Jesse A Rudd-Schmidt, Jamie A Lopez, Kelly M Ramsbottom, Stuart I Mannering, Daniel M Andrews, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2015  |  JOURNAL OF EXPERIMENTAL MEDICINE

Why Australia needs a Medical Research Future Fund

Anthony L Cunningham, Teresa Anderson, Christine C Bennett, Brendan S Crabb, Gareth Goodier, Douglas Hilton, Elizabeth Koff, Joe Trapani

Journal article  |  2015  |  Medical Journal of Australia

A Radio-Resistant Perforin-Expressing Lymphoid Population Controls Allogeneic T Cell Engraftment, Activation, and Onset of Graft-versus-Host Disease in Mice

Joanne E Davis, Michael Harvey, Nicholas A Gherardin, Rachel Koldej, Nicholas Huntington, Paul Neeson, Joseph A Trapani, David S Ritchie

Journal article  |  2015  |  Biology of Blood and Marrow Transplantation

Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin

Natalya Lukoyanova, Stephanie C Kondos, Irene Farabella, Ruby HP Law, Cyril F Reboul, Tom T Caradoc-Davies, Bradley A Spicer, Oded Kleifeld, Daouda AK Traore, Susan M Ekkel, Ilia Voskoboinik, Joseph A Trapani, Tamas Hatfaludi, Katherine Oliver, Eileen M Hotze, Rodney K Tweten, James C Whisstock, Maya Topf, Helen R Saibil, Michelle A Dunstone

Journal article  |  2015  |  PLOS Biology

Induction of potent NK cell-dependent anti-myeloma cytotoxic T cells in response to combined mapatumumab and bortezomib

Paul J Neeson, Andy K Hsu, Yin R Chen, Heloise M Halse, Joanna Loh, Reece Cordy, Kate Fielding, Joanne Davis, Josh Noske, Alex J Davenport, Camilla A Lindqvist-Gigg, Robin Humphreys, Tsin Tai, H Miles Prince, Joseph A Trapani, Mark J Smyth, David S Ritchie

Journal article  |  2015  |  OncoImmunology

Perforin-dependent cytotoxicity: 'Kiss of death' or prolonged embrace with darker consequences?

Joseph A Trapani, Ilia Voskoboinik, Misty R Jenkins

Journal article  |  2015  |  OncoImmunology

CAR-T cells are serial killers

Alexander J Davenport, Misty R Jenkins, David S Ritchie, H Miles Prince, Joseph A Trapani, Michael H Kershaw, Phillip K Darcy, Paul J Neeson

Journal article  |  2015  |  OncoImmunology

A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection

Christopher E Andoniou, Vivien R Sutton, Matthew E Wikstrom, Peter Fleming, Kevin YT Thia, Antony Y Matthews, Dion Kaiserman, Iona S Schuster, Jerome D Coudert, Preethi Eldi, Geeta Chaudhri, Gunasegaran Karupiah, Phillip I Bird, Joseph A Trapani, Mariapia A Degli-Esposti

Journal article  |  2014  |  PLoS Pathogens

A Method for Detecting Intracellular Perforin in Mouse Lymphocytes

Amelia J Brennan, Imran G House, Jane Oliaro, Kelly M Ramsbottom, Magdalena Hagn, Hideo Yagita, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2014  |  The Journal of Immunology

A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl

Magdalena Hagn, Vivien R Sutton, Joseph A Trapani

Journal article  |  2014  |  Journal of Visualized Experiments

TRAIL( ) NK Cells Control CD4( ) T Cell Responses during Chronic Viral Infection to Limit Autoimmunity

Iona S Schuster, Matthew E Wikstrom, Geraldine Brizard, Jerome D Coudert, Marie J Estcourt, Mitali Manzur, Lorraine A O'Reilly, Mark J Smyth, Joseph A Trapani, Geoffrey R Hill, Christopher E Andoniou, Mariapia A Degli-Esposti

Journal article  |  2014  |  Immunity

Familial haemophagocytic lymphohistiocytosis: Australian experience and perspectives

I Voskoboinik, K Thia, JA Trapani

Journal article  |  2014  |  Internal Medicine Journal

B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21

Magdalena Hagn, Sue E Blackwell, Thamara Beyer, Verena Ebel, Dorit Fabricius, Stefanie Lindner, Stefan Stilgenbauer, Thomas Simmet, Constantine Tam, Paul Neeson, Joseph A Trapani, Hubert Schrezenmeier, George J Weiner, Bernd Jahrsdoerfer

Journal article  |  2014  |  International Immunology

A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage

D Brasacchio, T Noori, C House, AJ Brennan, KJ Simpson, O Susanto, PI Bird, RW Johnstone, JA Trapani

Journal article  |  2014  |  Cell Death & Differentiation

The Perforin Pore Facilitates the Delivery of Cationic Cargos

Sarah E Stewart, Stephanie C Kondos, Antony Y Matthews, Michael E D'Angelo, Michelle A Dunstone, James C Whisstock, Joseph A Trapani, Phillip I Bird

Journal article  |  2014  |  Journal of Biological Chemistry

NK cell intrinsic regulation of MIP-1 alpha by granzyme M

N Baschuk, N Wang, SV Watt, H Halse, C House, PI Bird, R Strugnell, JA Trapani, MJ Smyth, DM Andrews

Journal article  |  2014  |  CELL DEATH & DISEASE

Granzyme H Is a Novel Protease Expressed by Human Mast Cells

Elin Ronnberg, Gabriela Calounova, Vivien R Sutton, Joseph A Trapani, Ola Rollman, Eva Hagforsen, Gunnar Pejler

Journal article  |  2014  |  International Archives of Allergy and Immunology

Defining the interaction of perforin with calcium and the phospholipid membrane

Daouda AK Traore, Amelia J Brennan, Ruby HP Law, Con Dogovski, Matthew A Perugini, Natalya Lukoyanova, Eleanor WW Leung, Raymond S Norton, Jamie A Lopez, Kylie A Browne, Hideo Yagita, Gordon J Lloyd, Annette Ciccone, Sandra Verschoor, Joseph A Trapani, James C Whisstock, Ilia Voskoboinik

Journal article  |  2013  |  BIOCHEMICAL JOURNAL

Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

Julie A Spicer, Gersande Lena, Dani M Lyons, Kristiina M Huttunen, Christian K Miller, Patrick D O'Connor, Matthew Bull, Nuala Helsby, Stephen MF Jamieson, William A Denny, Annette Ciccone, Kylie A Browne, Jamie A Lopez, Jesse Rudd-Schmidt, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2013  |  Journal of Medicinal Chemistry

Persistence and Efficacy of Second Generation CAR T Cell Against the LeY Antigen in Acute Myeloid Leukemia

David S Ritchie, Paul J Neeson, Amit Khot, Stefan Peinert, Tsin Tai, Kellie Tainton, Karen Chen, Mandy Shin, Dominic M Wall, Dirk Hoenemann, Peter Gambell, David A Westerman, Javier Haurat, Jennifer A Westwood, Andrew M Scott, Lucy Kravets, Michael Dickinson, Joseph A Trapani, Mark J Smyth, Phillip K Darcy, et al.

Journal article  |  2013  |  Molecular Therapy

Cloning and characterising an unusual perforin from chicken (Gallus gallus)

Michael E D'Angelo, Arash Arjomand, Joseph A Trapani, Phillip I Bird

Journal article  |  2013  |  Developmental and Comparative Immunology

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis

O Susanto, SE Stewart, I Voskoboinik, D Brasacchio, M Hagn, S Ellis, S Asquith, KA Sedelies, PI Bird, NJ Waterhouse, JA Trapani

Journal article  |  2013  |  Cell Death & Differentiation

Rapid and Unidirectional Perforin Pore Delivery at the Cytotoxic Immune Synapse

Jamie A Lopez, Misty R Jenkins, Jesse A Rudd-Schmidt, Amelia J Brennan, Jillian C Danne, Stuart I Mannering, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2013  |  JOURNAL OF IMMUNOLOGY

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

Jamie A Lopez, Olivia Susanto, Misty R Jenkins, Natalya Lukoyanova, Vivien R Sutton, Ruby HP Law, Angus Johnston, Catherina H Bird, Phillip I Bird, James C Whisstock, Joseph A Trapani, Helen R Saibil, Ilia Voskoboinik

Journal article  |  2013  |  BLOOD

Human perforin mutations and susceptibility to multiple primary cancers

Joseph A Trapani, Kevin YT Thia, Miles Andrews, Ian D Davis, Craig Gedye, Philip Parente, Suzanne Svobodova, Jenny Chia, Kylie Browne, Ian G Campbell, Wayne A Phillips, Ilia Voskoboinik, Jonathan S Cebon

Journal article  |  2013  |  ONCOIMMUNOLOGY

Surprisingly variable "dangers, toils, and snares" faced by humans and mice

Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2013  |  BLOOD

Perforinopatly: a spectrum of human immune disease caused by defective perforin delivery or function

Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2013  |  FRONTIERS IN IMMUNOLOGY

Controversies in granzyme biology

O Susanto, JA Trapani, D Brasacchio

Journal article  |  2012  |  Tissue Antigens

Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death

Jamie A Lopez, Amelia J Brennan, James C Whisstock, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2012  |  Trends in Immunology (formerly Immunology Today)

Granzyme B Is Dispensable in the Development of Diabetes in Non-Obese Diabetic Mice

Zia U Mollah, Kate L Graham, Balasubramanian Krishnamurthy, Prerak Trivedi, Thomas C Brodnicki, Joseph A Trapani, Thomas W Kay, Helen E Thomas

Journal article  |  2012  |  PLoS One

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737

VR Sutton, K Sedelies, G Dewson, ME Christensen, PI Bird, RW Johnstone, RM Kluck, JA Trapani, NJ Waterhouse

Journal article  |  2012  |  Cell Death & Disease

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi

Michael E D'Angelo, Michelle A Dunstone, James C Whisstock, Joseph A Trapani, Phillip I Bird

Journal article  |  2012  |  BMC Evolutionary Biology

Activated Mouse B Cells Lack Expression of Granzyme B

Magdalena Hagn, Gabrielle T Belz, Axel Kallies, Vivien R Sutton, Kevin Y Thia, David M Tarlinton, Edwin D Hawkins, Joseph A Trapani

Journal article  |  2012  |  Journal of Immunology

A novel role for granzymes in anti-tumor immunity

Sabine Hoves, Vivien R Sutton, Joseph A Trapani

Journal article  |  2012  |  OncoImmunology

Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin

Jenny Chia, Kevin Thia, Amelia J Brennan, Margaret Little, Bronwyn Williams, Jamie A Lopez, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2012  |  BLOOD

Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones

Julie A Spicer, Kristiina M Huttunen, Christian K Miller, William A Denny, Annette Ciccone, Kylie A Browne, Joseph A Trapani

Journal article  |  2012  |  Bioorganic & Medicinal Chemistry

Granzymes, cytotoxic granules and cell death: the early work of Dr. Jurg Tschopp

JA Trapani

Journal article  |  2012  |  Cell Death & Differentiation

Response Dexamethasone dose alters expression of NK activating receptors in vivo

Andy Hsu, Hang Quach, Tsin Tai, H Miles Prince, Simon J Harrison, Joseph A Trapani, Mark J Smyth, Paul J Neeson, David S Ritchie

Journal article  |  2011  |  Blood

Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin

Daniel M Andrews, Melvyn T Chow, Yuting Ma, Claire L Cotterell, Sally V Watt, Desiree A Anthony, Shizuo Akira, Yoichiro Iwakura, Joseph A Trapani, Laurence Zitvogel, Mark J Smyth

Journal article  |  2011  |  Immunology and Cell Biology

A Critical Role for Granzymes in Antigen Cross-Presentation through Regulating Phagocytosis of Killed Tumor Cells

Sabine Hoves, Vivien R Sutton, Nicole M Haynes, Edwin D Hawkins, Daniel Fernandez Ruiz, Nikola Baschuk, Karin A Sedelies, Maximilian Schnurr, John Stagg, Daniel M Andrews, Jose A Villadangos, Joseph A Trapani

Journal article  |  2011  |  Journal of Immunology

Inhibition of the cellular function of perforin by 1-amino-2, 4-dicyanopyrido[1,2-a]benzimidazoles

Dani M Lyons, Kristiina M Huttunen, Kylie A Browne, Annette Ciccone, Joseph A Trapani, William A Denny, Julie A Spicer

Journal article  |  2011  |  Bioorganic & Medicinal Chemistry

Protection from Endogenous Perforin: Glycans and the C Terminus Regulate Exocytic Trafficking in Cytotoxic Lymphocytes

Amelia J Brennan, Jenny Chia, Kylie A Browne, Annette Ciccone, Sarah Ellis, Jamie A Lopez, Olivia Susanto, Sandra Verschoor, Hideo Yagita, James C Whisstock, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2011  |  Immunity

Cathepsin C limits acute viral infection independently of NK cell and CD8( ) T-cell cytolytic function

Christopher E Andoniou, Peter Fleming, Vivien R Sutton, Joseph A Trapani, Mariapia A Degli-Esposti

Journal article  |  2011  |  Immunology and Cell Biology

The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy

Andy K Hsu, Hang Quach, Tsin Tai, H Miles Prince, Simon J Harrison, Joseph A Trapani, Mark J Smyth, Paul Neeson, David S Ritchie

Journal article  |  2011  |  Blood

Cytotoxic granules house potent proapoptotic toxins critical for antiviral responses and immune homeostasis

K Baran, I Voskoboinik, NJ Waterhouse, VR Sutton, JA Trapani

Book Chapter  |  2011

Tumor Ablation by Gene-Modified T Cells in the Absence of Autoimmunity

Leanne XJ Wang, Jennifer A Westwood, Maria Moeller, Connie PM Duong, Wei-Zen Wei, Jordane Malaterre, Joseph A Trapani, Paul Neeson, Mark J Smyth, Michael H Kershaw, Phillip K Darcy

Journal article  |  2010  |  Cancer Research

The structural basis for membrane binding and pore formation by lymphocyte perforin

Ruby HP Law, Natalya Lukoyanova, Ilia Voskoboinik, Tom T Caradoc-Davies, Katherine Baran, Michelle A Dunstone, Michael E D'Angelo, Elena V Orlova, Fasseli Coulibaly, Sandra Verschoor, Kylie A Browne, Annette Ciccone, Michael J Kuiper, Phillip I Bird, Joseph A Trapani, Helen R Saibil, James C Whisstock

Journal article  |  2010  |  Nature

The structure and function of mammalian membrane-attack complex/perforin-like proteins

SC Kondos, T Hatfaludi, I Voskoboinik, JA Trapani, RHP Law, JC Whisstock, MA Dunstone

Journal article  |  2010  |  Tissue Antigens

Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L

Spela Konjar, Vivien R Sutton, Sabine Hoves, Urska Repnik, Hideo Yagita, Thomas Reinheckel, Christoph Peters, Vito Turk, Boris Turk, Joseph A Trapani, Natasa Kopitar-Jerala

Journal article  |  2010  |  Immunology

Ex vivo culture of chimeric antigen receptor T cells generates functional CD8( ) T cells with effector and central memory-like phenotype

P Neeson, A Shin, KM Tainton, P Guru, HM Prince, SJ Harrison, S Peinert, MJ Smyth, JA Trapani, MH Kershaw, PK Darcy, DS Ritchie

Journal article  |  2010  |  Gene Therapy

Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining

Vivien R Sutton, Joseph A Trapani

Conference Proceedings  |  2010  |  Biological Chemistry

A Role for Granzyme M in TLR4-Driven Inflammation and Endotoxicosis

Desiree A Anthony, Daniel M Andrews, Melvyn Chow, Sally V Watt, Colin House, Shizuo Akira, Phillip I Bird, Joseph A Trapani, Mark J Smyth

Journal article  |  2010  |  The Journal of Immunology

Cathepsin H Is an Additional Convertase of Pro-granzyme B

Michael E D'Angelo, Phillip I Bird, Christoph Peters, Thomas Reinheckel, Joseph A Trapani, Vivien R Sutton

Journal article  |  2010  |  Journal of Biological Chemistry

Perforin: structure, function, and role in human immunopathology

Ilia Voskoboinik, Michelle A Dunstone, Katherine Baran, James C Whisstock, Joseph A Trapani

Journal article  |  2010  |  Immunological Reviews

Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen

S Peinert, HM Prince, PM Guru, MH Kershaw, MJ Smyth, JA Trapani, P Gambell, S Harrison, AM Scott, FE Smyth, PK Darcy, K Tainton, P Neeson, DS Ritchie, D Hoenemann

Journal article  |  2010  |  Gene Therapy

Functional dissection of the granzyme family: cell death and inflammation

Desiree A Anthony, Daniel M Andrews, Sally V Watt, Joseph A Trapani, Mark J Smyth

Journal article  |  2010  |  Immunological Reviews

The role of perforin and granzymes in diabetes

HE Thomas, JA Trapani, TWH Kay

Journal article  |  2010  |  Cell Death & Differentiation

Functional Crosstalk between Type I and II Interferon through the Regulated Expression of STAT1

Daniel J Gough, Nicole L Messina, Linda Hii, Jodee A Gould, Kanaga Sabapathy, Ashley PS Robertson, Joseph A Trapani, David E Levy, Paul J Hertzog, Christopher JP Clarke, Ricky W Johnstone

Journal article  |  2010  |  PLoS Biology

Perforin deficiency and susceptibility to cancer

AJ Brennan, J Chia, JA Trapani, I Voskoboinik

Journal article  |  2010  |  Cell Death & Differentiation

The battlefield of perforin/granzyme cell death pathways

Sabine Hoves, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2010  |  Journal of Leukocyte Biology

Incentives: Encouraging Adventurous Ideas

Joseph A Trapani, Antony W Burgess, David J Hill

Journal article  |  2010  |  Science

Endolysosomal proteases and their inhibitors in immunity

Phillip I Bird, Joseph A Trapani, Jose A Villadangos

Journal article  |  2009  |  Nature Reviews Immunology

Proteolytic Activation of the Cytotoxic Phenotype during Human NK Cell Development

Josephine L Meade, Erica B Wilson, Tim D Holmes, Erika A de Wynter, Peter Brett, Liz Straszynski, Paul AS Ballard, Joseph A Trapani, Michael F McDermott, Graham P Cook

Journal article  |  2009  |  The Journal of Immunology

Cutting Edge: Rapid and Efficient In Vivo Cytotoxicity Cytotoxic T Cells Is Independent of Granzymes A and B

Matthias Regner, Lisa Pavlinovic, Aulikki Koskinen, Nicolie Young, Joseph A Trapani, Arno Muellbacher

Journal article  |  2009  |  The Journal of Immunology

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

Jenny Chia, Kim Pin Yeo, James C Whisstock, Michelle A Dunstone, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

The Molecular Basis for Perforin Oligomerization and Transmembrane Pore Assembly

Katherine Baran, Michelle Dunstone, Jenny Chia, Annette Ciccone, Kylie A Browne, Christopher JP Clarke, Natalya Lukoyanova, Helen Saibil, James C Whisstock, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2009  |  Immunity

EMBO workshop on cytotoxicity, cell death and the immune system

A Anel, C Bleackley, C Borner, P Golstein, PH Krammer, A Muellbacher, J Pardo, MM Simon, JA Trapani

Journal article  |  2009  |  Cell Death & Differentiation

The Lewis-Y Carbohydrate Antigen is Expressed by Many Human Tumors and Can Serve as a Target for Genetically Redirected T cells Despite the Presence of Soluble Antigen in Serum

Jennifer A Westwood, William K Murray, Melanie Trivett, Nicole M Haynes, Benjamin Solomon, Linda Mileshkin, David Ball, Michael Michael, Angela Burman, Preethi Mayura-Guru, Joseph A Trapani, Stefan Peinert, Dirk Honemann, H Miles Prince, Andrew M Scott, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2009  |  Journal of Immunotherapy

Visualizing CTL activity for different CD8( ) effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing

MR Jenkins, NL La Gruta, PC Doherty, JA Trapani, SJ Turner, NJ Waterhouse

Journal article  |  2009  |  Cell Death & Differentiation

Perforin-mediated suppression of B-cell lymphoma

Paul Bolitho, Shayna EA Street, Jennifer A Westwood, Winfried Edelmann, Duncan MacGregor, Paul Waring, William K Murray, Dale I Godfrey, Joseph A Trapani, Ricky W Johnstone, Mark J Smyth

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

Granule-mediated death by cytotoxic lymphocytes does not require mitochondrial polarization toward the immunologic synapse in target cells

Olivia Susanto, Karin Sedelies, Joe Trapani, Nigel Waterhouse

Journal article  |  2009  |  Blood

Dihydrofuro[3,4-c]pyridinones as Inhibitors of the Cytolytic Effects of the Pore-Forming Glycoprotein Perforin

Gersande Lena, Joseph A Trapani, Vivien R Sutton, Annette Ciccone, Kylie A Browne, Mark J Smyth, William A Denny, Julie A Spicer

Journal article  |  2008  |  Journal of Medicinal Chemistry

A Renaissance in Understanding the Multiple and Diverse Functions of Granzymes?

Joseph A Trapani, Phillip I Bird

Journal article  |  2008  |  Immunity

Investigation of the role of gene-modified CD4( ) T cell subsets for cancer immunotherapy

Phillip Darcy, Maria Moeller, Joseph Trapani, Mark Smyth, Michael Kershaw

Conference Proceedings  |  2008  |  HUMAN GENE THERAPY

The MACPF/CDC family of pore-forming toxins

Carlos J Rosado, Stephanie Kondos, Tara E Bull, Michael J Kuiper, Ruby HP Law, Ashley M Buckle, Ilia Voskoboinik, Phillip I Bird, Joseph A Trapani, James C Whisstock, Michelle A Dunstone

Journal article  |  2008  |  Cellular Immunology

Granzyme K Expressing Cytotoxic T Lymphocytes Protects Against Influenza Virus in Granzyme AB(-/-) Mice

Misty R Jenkins, Joseph A Trapani, Peter C Doherty, Stephen J Turner

Journal article  |  2008  |  Viral Immunology

Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice

JA Westwood, WK Murray, M Trivett, A Shin, P Neeson, DP MacGregor, NM Haynes, JA Trapani, P Mayura-Guru, S Fox, S Peinert, D Honemann, HM Prince, D Ritchie, AM Scott, FE Smyth, MJ Smyth, PK Darcy, MH Kershaw

Journal article  |  2008  |  Gene Therapy

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity

KA Sedelies, A Ciccone, CJP Clarke, J Oliaro, VR Sutton, FL Scott, J Silke, O Susanto, DR Green, RW Johnstone, PI Bird, JA Trapani, NJ Waterhouse

Journal article  |  2008  |  Cell Death & Differentiation

Cloning and characterisation of IFi206: A new murine HIN-200 family member

Louise E Ludlow, Linda L Hii, Janine Thorpe, Andrea Newbold, Kellie M Tainton, Joseph A Trapani, Christopher JP Clarke, Ricky W Johnstone

Journal article  |  2008  |  Journal of Cellular Biochemistry

Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules

Vivien R Sutton, Nigel J Waterhouse, Katherine Baran, Kylie Browne, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2008  |  Methods

The role of p202 in regulating hematopoietic cell proliferation and differentiation (Journal of Interferon and Cytokine Research 28, 1, (5-11))

LE Ludlow, LE Purton, K Klarmann, DJ Gough, LL Hii, JA Trapani, JR Keller, CJP Clarke, RW Johnstone

Journal article  |  2008  |  Journal of Interferon & Cytokine Research

The role of p202 in regulating hematopoietic cell proliferation and differentiation

Louise E Ludlow, Louise E Purton, Kim Klarmann, Daniel J Gough, Linda L Hii, Joseph A Trapani, Jonathan R Keller, Christopher JP Clarke, Ricky W Johnstone

Journal article  |  2008  |  Journal of Interferon and Cytokine Research

Sustained antigen-specific antitumor recall response mediated by gene-modified CD4( ) T helper-1 and CD8( ) T cells

Maria Moeller, Michael H Kershaw, Rachel Cameron, Jennifer A Westwood, Joseph A Trapani, Mark J Smyth, Phillip K Darcy

Journal article  |  2007  |  Cancer Research

A common fold mediates vertebrate defense and bacterial attack

Carlos J Rosado, Ashley M Buckle, Ruby HP Law, Rebecca E Butcher, Wan-Ting Kan, Catherina H Bird, Kheng Ung, Kylie A Browne, Katherine Baran, Tanya A Bashtannyk-Puhalovich, Noel G Faux, Wilson Wong, Corrine J Porter, Robert N Pike, Andrew M Ellisdon, Mary C Pearce, Stephen P Bottomley, Jonas Emsley, A Ian Smith, Jamie Rossjohn, et al.

Journal article  |  2007  |  Science

H is for helper: Granzyme H helps granzyme B kill adenovirus-infected cells

Nigel J Waterhouse, Joseph A Trapani

Journal article  |  2007  |  Trends in Immunology

The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains

Kevin YT Thia, Joseph A Trapani

Journal article  |  2007  |  Tissue Antigens

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

Ilia Voskoboinik, Vivien R Sutton, Annette Ciccone, Colin M House, Jenny Chia, Phillip K Darcy, Hideo Yagita, Joseph A Trapani

Journal article  |  2007  |  Immunobiology

The constitutive secretion of type I interferon is necessary for maintenance of STAT1 expression and cross-talk between type I and IIIFN

Daniel J Gough, Jodee A Gould, Paul J Hertzog, Nicole Messina, Kanaga Sabapathy, Joseph A Trapani, Christophe JP Clarke, Ricky W Johnstone

Conference Proceedings  |  2007  |  Cytokine

Apoptosis induced by the lymphocyte effector molecule perforin

Paul Bolitho, Ilia Voskoboinik, Joseph A Trapani, Mark J Smyth

Journal article  |  2007  |  Current Opinion in Immunology

The complex issue of regulating perforin expression

Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2007  |  Trends in Immunology (formerly Immunology Today)

Gene-modified T cells targeting lewis positive myeloma

D Honemann, P Guru, JA Westwood, MH Kershaw, MJ Smyth, JA Trapani, AM Scott, FE Smyth, GA Cartwright, BE Power, PK Darcy, S Peinert, D Westerman, P Gambell, HM Prince

Conference Proceedings  |  2007  |  HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis

Vivien R Sutton, Nigel J Waterhouse, Kylie A Browne, Karin Sedelies, Annette Ciccone, Desiree Anthony, Aulikki Koskinen, Arno Mullbacher, Joseph A Trapani

Journal article  |  2007  |  Journal of Cell Biology

A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes

Daniel J Gough, Kanaga Sabapathy, Enoch Yi-No Ko, Helen A Arthur, Robert D Schreiber, Joseph A Trapani, Christopher JP Clarke, Ricky W Johnstone

Journal article  |  2007  |  Journal of Biological Chemistry

Infective, neoplastic, and homeostatic sequelae of the loss of perforin function in humans

Joseph A Trapani, Ilia Voskoboinik

Conference Proceedings  |  2007  |  Advances in Experimental Medicine and Biology

Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation

Jane Oliaro, Anupama Pasam, Nigel J Waterhouse, Kylie A Browne, Mandy J Ludford-Menting, Joseph A Trapani, Sarah M Russell

Journal article  |  2006  |  Proceedings of the National Academy of Sciences of the United States of America

Perforin-mediated target-cell death and immune homeostasis

Ilia Voskoboinik, Mark J Smyth, Joseph A Trapani

Journal article  |  2006  |  Nature Reviews Immunology

The major human and mouse granzymes are structurally and functionally divergent

Dion Kaiserman, Catherina H Bird, Jiuru Sun, Antony Matthews, Kheng Ung, James C Whisstock, Philip E Thompson, Joseph A Trapani, Phillip I Bird

Journal article  |  2006  |  Journal of Cell Biology

Adoptive transfer of carbohydrate-specific T cells for cancer therapy

Jennifer A Westwood, Mark J Smyth, Michele W Teng, Joseph A Trapani, Andrew M Scott, Fiona E Smyth, Glenn Cartwright, Barbara E Power, Dirk Honemann, Miles Prince, Phillip K Darcy, Michael H Kershaw

Conference Proceedings  |  2006  |  JOURNAL OF IMMUNOTHERAPY

Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells

Katherine Baran, Annette Ciccone, Christoph Peters, Hideo Yagita, Phillip I Bird, Jose A Villadangos, Joseph A Trapani

Journal article  |  2006  |  Journal of Biological Chemistry

Cytotoxic T-Cells from T-Cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and fas pathways

Nadine L Dudek, Helen E Thomas, Lina Mariana, Robyn M Sutherland, Janette Allison, Eugene Estella, Eveline Angstetra, Joseph A Trapani, Pere Santamaria, Andrew M Lew, Thomas WH Kay

Journal article  |  2006  |  Diabetes

Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid

Eugene Estella, Mark D McKenzie, Tara Catterall, Vivien R Sutton, Phillip I Bird, Joseph A Trapani, Thomas W Kay, Helen E Thomas

Journal article  |  2006  |  Diabetes

Perforin and Fas induced by IFN gamma and TNF alpha mediate beta cell death by OT-I CTL

Mark D McKenzie, Nadine L Dudek, Lina Mariana, Mark MW Chong, Joseph A Trapani, Thomas WH Kay, Helen E Thomas

Journal article  |  2006  |  International Immunology

Unravelling the mysteries of Perforin

I Voskoboinik, JA Trapani

Journal article  |  2006  |  KLINISCHE PADIATRIE

Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

NJ Waterhouse, VR Sutton, KA Sedelies, A Ciccone, M Jenkins, SJ Turner, PI Bird, JA Trapani

Journal article  |  2006  |  Journal of Cell Biology

Functional dissociation of Delta Psi m and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis

NJ Waterhouse, KA Sedelies, VR Sutton, MJ Pinkoski, KY Thia, R Johnstone, PI Bird, DR Green, JA Trapani

Journal article  |  2006  |  Cell Death & Differentiation

Addressing the mysteries of perforin function

I Voskoboinik, JA Trapani

Journal article  |  2006  |  Immunology & Cell Biology

Report on apoptosis and immunity, 31 May-3 June 2005, Palm Cove, Queensland, Australia

JA Trapani, MJ Smyth

Journal article  |  2006  |  Immunology & Cell Biology

Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis

NJ Waterhouse, KA Sedelies, JA Trapani

Journal article  |  2006  |  Immunology & Cell Biology

A critical role for granzyme B, in addition to perforin and TNF alpha, in alloreactive CTL-induced mouse pancreatic beta cell death

VR Sutton, E Estella, C Li, M Chen, HE Thomas, TW Kay, JA Trapani

Journal article  |  2006  |  Transplantation

Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice

JA Westwood, MJ Smyth, MWL Teng, M Moeller, JA Trapani, AM Scott, FE Smyth, GA Cartwright, BE Power, D Honemann, HM Prince, PK Darcy, MH Kershaw

Journal article  |  2005  |  Proceedings of the National Academy of Sciences

Functional characterization of a humanized chimeric gene for the redirection of lymphocytes against the Lewis-Y tumor-associated carbohydrate antigen

JA Westwood, MJ Smyth, MW Tang, JA Trapani, AM Scott, FE Smyth, GA Cartwright, BE Power, D Honemann, PK Darcy, MH Kershaw

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

Anti-tumor function of gene-modified T cells in a self-antigen mouse model

M Moeller, MH Kershaw, R Cameron, MWL Teng, JA Trapani, MJ Smyth, PK Darcy

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

Adoptive transfer of gene-engineered CD4( ) helper T cells induces potent primary and secondary tumor rejection

M Moeller, NM Haynes, MH Kershaw, JT Jackson, MWL Teng, SE Street, L Cerutti, SM Jane, JA Trapani, MJ Smyth, PK Darcy

Journal article  |  2005  |  Blood

A structure/function analysis of lymphocyte perform: Valuable lessons from perforin mutations identified in FHL

I Voskoboinik, JA Trapani

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

Perforin and fas induced by interferon-gamma and tumour necrosis factor mediate beta-cell death by OT-1 cytotoxic T lymphocytes

MD McKenzie, NL Dudek, L Mariana, MMW Chong, JA Trapani, TWH Kay, HE Thomas

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

The dual adverse effects of TGF-beta secretion on tumor progression

JA Trapani

Journal article  |  2005  |  Cancer Cell

Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells

CH Bird, J Sun, K Ung, D Karambalis, JC Whisstock, JA Trapani, PI Bird

Journal article  |  2005  |  Molecular and Cellular Biology

Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin

MS Buzza, L Zamurs, JR Sun, CH Bird, AI Smith, JA Trapani, CJ Froelich, EC Nice, PI Bird

Journal article  |  2005  |  Journal of Biological Chemistry

A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis

I Voskoboinik, MC Thia, JA Trapani

Journal article  |  2005  |  Blood

Lack of apoptosis of Sezary cells in the circulation following oral bexarotene therapy

S Brennand, VR Sutton, J Biagi, JA Trapani, D Westerman, CJ McCormack, JF Seymour, G Kennedy, HM Prince

Journal article  |  2005  |  British Journal of Dermatology

Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: Modulation by the serpin inhibitor PI-9

EJ Blink, JS Zhou, W Hu, ST Calanni, JA Trapani, PI Bird, DA Jans

Journal article  |  2005  |  Journal of Cellular Biochemistry

Immune surveillance of lymphoma in humans?

MJ Smyth, I Voskoboinik, JA Trapani

Journal article  |  2005  |  Blood

Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain

I Voskoboinik, MC Thia, J Fletcher, A Ciccone, K Browne, MJ Smyth, JA Trapani

Journal article  |  2005  |  Journal of Biological Chemistry

A central role for bid in granzyme B-induced apoptosis

NJ Waterhouse, KA Sedelies, KA Browne, ME Wowk, A Newbold, VR Sutton, CJP Clarke, J Oliaro, RK Lindemann, PI Bird, RW Johnstone, JA Trapani

Journal article  |  2005  |  Journal of Biological Chemistry

Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2

KS Cresswell, CJP Clarke, JT Jackson, PK Darcy, JA Trapani, RW Johnstone

Journal article  |  2005  |  Biochemical and Biophysical Research Communications

The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene

I Voskoboinik, MC Thia, A De Bono, K Browne, E Cretney, JT Jackson, PK Darcy, SM Jane, MJ Smyth, JA Trapani

Journal article  |  2004  |  Journal of Experimental Medicine

Cytotoxic lymphocytes; instigators of dramatic target cell death

NJ Waterhouse, CJP Clarke, KA Sedelies, MW Teng, JA Trapani

Journal article  |  2004  |  Biochemical Pharmacology

Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer

MH Kershaw, JT Jackson, NM Haynes, MWL Teng, M Moeller, Y Hayakawa, SE Street, R Cameron, JE Tanner, JA Trapani, MJ Smyth, PK Darcy

Journal article  |  2004  |  Journal of Immunology

Cytotoxic activity of the lymphocyte toxin granzyme B

ME Wowk, JA Trapani

Journal article  |  2004  |  Microbes and Infection

Discordant regulation of granzyme H and granzyme B expression in human lymphocytes

KA Sedelies, TJ Sayers, KM Edwards, WS Chen, DG Pellicci, DI Godfrey, JA Trapani

Journal article  |  2004  |  Journal of Biological Chemistry

Granzyme M mediates a novel form of perforin-dependent cell death

JM Kelly, NJ Waterhouse, E Cretney, KA Browne, S Ellis, JA Trapani, MJ Smyth

Journal article  |  2004  |  Journal of Biological Chemistry

A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells

M Moeller, NM Haynes, JA Trapani, MWL Teng, JT Jackson, JE Tanner, L Cerutti, SM Jane, MH Kershaw, MJ Smyth, PK Darcy

Journal article  |  2004  |  Cancer Gene Therapy

Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity

JR Sun, CH Bird, KY Thia, AY Matthews, JA Trapani, PI Bird

Journal article  |  2004  |  Journal of Biological Chemistry

Assaying cytochrome C translocation during apoptosis.

Nigel J Waterhouse, Rohan Steel, Ruth Kluck, Joseph A Trapani

Book Chapter  |  2004  |  Methods in Molecular Biology

Translocation of proteins from the mitochondrial intermembrane space to the cytoplasm is a critical event during apoptosis. There ..

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble

LE Dow, AM Brumby, R Muratore, ML Coombe, KA Sedelies, JA Trapani, SM Russell, HE Richardson, PO Humbert

Journal article  |  2003  |  Oncogene

Granzyme B: pro-apoptotic, antiviral and antitumor functions

JA Trapani, VR Sutton

Journal article  |  2003  |  Current Opinion in Immunology

Novel mechanisms of apoptosis induced by histone deacetylase inhibitors

MJ Peart, KM Tainton, AA Ruefli, AE Dear, KA Sedelies, LA O'Reilly, NJ Waterhouse, JA Trapani, RW Johnstone

Journal article  |  2003  |  Cancer Research

Cutting edge: Granzymes A and B are not essential for perforin-mediated tumor rejection

MJ Smyth, SEA Street, AA Trapani

Journal article  |  2003  |  Journal of Immunology

A new quantitative assay for cytochrome c release in apoptotic cells

NJ Waterhouse, JA Trapani

Journal article  |  2003  |  Cell Death & Differentiation

Purification of natural killer cell cytotoxic granules for assaying target cell apoptosis

JE Davis, VR Sutton, KA Browne, JA Trapani

Journal article  |  2003  |  Journal of Immunological Methods

Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16

CJP Clarke, V Apostolidis, LLP Hii, DJ Gough, JA Trapani, RW Johnstone

Journal article  |  2003  |  Journal of Cellular Biochemistry

Erratum: Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation (Journal of Immunology (2002) 169 (5780-5786))

NM Haynes, JA Trapani, MWL Teng, JT Jackson, L Cerruti, SM Jane, MH Kershaw, MJ Smyth, PK Darcy

Journal article  |  2003  |  Journal of Immunology

Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors

VR Sutton, ME Wowk, M Cancilla, JA Trapani

Journal article  |  2003  |  Immunity

A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death

JA Trapani, VR Sutton, KYT Thia, YQ Li, CJ Froelich, DA Jans, MS Sandrin, KA Browne

Journal article  |  2003  |  JOURNAL OF CELL BIOLOGY

Expression of IFI 16 in epithelial cells and lymphoid tissues

W Wei, CJP Clarke, GR Somers, KS Cresswell, KA Loveland, JA Trapani, RW Johnstone

Journal article  |  2003  |  Histochemistry and Cell Biology

Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation

NM Haynes, JA Trapani, MWL Teng, JT Jackson, L Cerruti, SM Jane, MH Kershaw, MJ Smyth, PK Darcy

Journal article  |  2002  |  Journal of Immunology

Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

NM Haynes, JA Trapani, MWL Teng, JT Jackson, L Cerruti, SM Jane, MH Kershaw, MJ Smyth, PK Darcy

Journal article  |  2002  |  Gene Therapy

Functional significance of the perforin/granzyme cell death pathway

JA Trapani, MJ Smyth

Journal article  |  2002  |  Nature Reviews Immunology

Tumor-mediated apoptosis of cancer-specific T lymphocytes - Reversing the "kiss of death"?

JA Trapani

Journal article  |  2002  |  Cancer Cell

Suppression of lymphoma and epithelial malignancies effected by interferon gamma

SEA Street, JA Trapani, D MacGregor, MJ Smyth

Journal article  |  2002  |  Journal of Experimental Medicine

Editorial

J Trapani

Journal article  |  2002  |  Tissue Antigens

Cytotoxic cell granule-mediated apoptosis: Perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

SS Metkar, BK Wang, M Aguilar-Santelises, SM Raja, L Uhlin-Hansen, E Podack, JA Trapani, CJ Froelich

Journal article  |  2002  |  Immunity

CTL: Caspases Terminate Life, but that's not the whole story

NJ Waterhouse, JA Trapani

Journal article  |  2002  |  Tissue Antigens

Functional role of phosphatidylinositol 3-kinase in direct tumor lysis by human natural killer cells

B Zhong, JH Liu, DL Gilvary, K Jiang, M Kasuga, CA Ritchey, JA Trapani, S Wei

Journal article  |  2002  |  Immunobiology

Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction

CE Hirst, MS Buzza, VR Sutton, JA Trapani, KL Loveland, PI Bird

Journal article  |  2001  |  Molecular Human Reproduction

Lymphocyte-mediated immunosurveillance of epithelial cancers?

MJ Smyth, JA Trapani

Journal article  |  2001  |  Trends in Immunology (formerly Immunology Today)

Mechanisms of interferon mediated anti-viral resistance.

CJ Clarke, JA Trapani, RW Johnstone

Journal article  |  2001  |  Current Drug Target - Immune, Endocrine & Metabolic Disorders

Interferons (IFNs) are an important part of immune responses and are believed to protect the host from viral and bacterial pathoge..

Unlocking the secrets of cytotoxic granule proteins

MJ Smyth, JM Kelly, VR Sutton, JE Davis, KA Browne, TJ Sayers, JA Trapani

Journal article  |  2001  |  Journal of Leukocyte Biology

A fresh look at tumor immunosurveillance and immunotherapy

MJ Smyth, DI Godfrey, JA Trapani

Journal article  |  2001  |  Nature Immunology

Dissecting the apoptotic mechanisms of chemotherapeutic drugs and lymphocytes to design effective anticancer therapies

AA Ruefli, JE Davis, VR Sutton, JA Trapani, MJ Smyth, RW Johnstone

Journal article  |  2001  |  Drug Development Research

Novel properties of the protein kinase CK2-site-regulated nuclear-localization sequence of the interferon-induced nuclear factor IFI 16

LJ Briggs, RW Johnstone, RM Elliot, CY Xiao, M Dawson, JA Trapani, DA Jans

Journal article  |  2001  |  Biochemical Journal

Optimizing therapeutic strategies to inhibit circulating soluble target molecules with monoclonal antibodies: example of the soluble IL-6 receptors.

J Brochier, J Liautard, C Jacquet, JP Gaillard, B Klein

Journal article  |  2001  |  European Journal of Immunology

Therapeutic targeting of soluble molecules such as cytokines can be achieved with monoclonal antibodies (mAb). Anti-IL-6 mAb have ..

Granzymes: a family of lymphocyte granule serine proteases

Joseph A Trapani

Journal article  |  2001  |  Genome Biology

Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity

JE Davis, MJ Smyth, JA Trapani

Journal article  |  2001  |  European Journal of Immunology

Redirecting mouse CTL against colon carcinoma: Superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma

NM Haynes, MB Snook, JA Trapani, L Cerruti, SM Jane, MJ Smyth, PK Darcy

Journal article  |  2001  |  Journal of Immunology

Novel properties of the protein kinase CK2-site-regulated nuclear-localization sequence of the interferon-induced nuclear factor IFI 16

LJ Briggs, RW Johnstone, RM Elliot, CY Xiao, M Dawson, JA Trapani, DA Jans

Journal article  |  2001  |  Biochemical Journal

Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis

KA Browne, RW Johnstone, DA Jans, JA Trapani

Journal article  |  2000  |  Journal of Biological Chemistry

Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16

RW Johnstone, W Wei, A Greenway, JA Trapani

Journal article  |  2000  |  Oncogene

Initiation of apoptosis by granzyme B requires direct cleavage of Bid, but not direct granzyme B-mediated caspase activation

VR Sutton, JE Davis, M Cancilla, RW Johnstone, AA Ruefli, K Sedelies, KA Browne, JA Trapani

Journal article  |  2000  |  Journal of Experimental Medicine

Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1

JE Davis, VR Sutton, MJ Smyth, JA Trapani

Journal article  |  2000  |  Cell Death & Differentiation

Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway

S Wei, DL Gilvary, BC Corliss, S Sebti, JZ Sun, DB Straus, PJ Leibson, JA Trapani, AD Hamilton, MJ Weber, JY Djeu

Journal article  |  2000  |  The Journal of Immunology

Destruction of tumor cells is a key function of lymphocytes, but the molecular processes driving it are unclear. Analysis of signa..

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

MJ Smyth, KYT Thia, SEA Street, D MacGregor, DI Godfrey, JA Trapani

Journal article  |  2000  |  The Journal of Experimental Medicine

Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo

JA Trapani, J Davis, VR Sutton, MJ Smyth

Journal article  |  2000  |  Current Opinion in Immunology

Redirected perforin-dependent lysis of colon carcinoma by ex vivo genetically engineered CTL

PK Darcy, NM Haynes, MB Snook, JA Trapani, L Cerruti, SM Jane, MJ Smyth

Journal article  |  2000  |  The Journal of Immunology

Differential tumor surveillance by natural killer (NK) and NKT cells

MJ Smyth, KYT Thia, SEA Street, E Cretney, JA Trapani, M Taniguchi, T Kawano, SB Pelikan, NY Crowe, DI Godfrey

Journal article  |  2000  |  The Journal of Experimental Medicine

A direct comparison of cytolytic T-lymphocyte responses to Melan-A peptides in vitro: differential immunogenicity of Melan-A(27-35) and Melan-A(26-35)

Q Chen, H Jackson, J Cebon, P Gibbs, ID Davis, JA Trapani

Journal article  |  2000  |  Melanoma Research

Erratum: A direct comparison of cytolytic T-lymphocyte responses to Melan-A peptides in vitro: Differential immunogenicity of Melan-A27-35 and Melan-A26-35 (Melanoma Research (2000) 10:1 (21))

Q Chen, H Jackson, J Cebon, P Gibbs, ID Davis, JA Trapani

Journal article  |  2000  |  Melanoma Research

Cytosolic delivery of granzyme B by bacterial toxins: Evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

KA Browne, E Blink, VR Sutton, CJ Froelich, DA Jans, JA Trapani

Journal article  |  1999  |  Molecular and Cellular Biology

Granule-mediated cell killing by cytotoxic lymphocytes requires the combined actions of a membranolytic protein, perforin, and gra..

The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes

HM Edwards, CM Kam, JC Powers, JA Trapani

Journal article  |  1999  |  Journal of Biological Chemistry

Serine proteases (granzymes) contained within the cytoplasmic granules of cytotoxic T cells and natural killer cells play a variet..

Transcription and growth regulatory functions of the HIN-200 family of proteins

RW Johnstone, JA Trapani

Journal article  |  1999  |  Molecular and Cellular Biology

CTL granules: evolution of vesicles essential for combating virus infections

JA Trapani, VR Sutton, MJ Smyth

Journal article  |  1999  |  Immunology Today

Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis?

EJ Blink, JA Trapani, DA Jans

Conference Proceedings  |  1999  |  Immunology and Cell Biology

Programmed cell death, apoptosis, involves very distinctive changes within the target cell nucleus, including margination of the c..

BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis

DA Jans, VR Sutton, P Jans, CJ Froelich, JA Trapani

Journal article  |  1999  |  Journal of Biological Chemistry

Cytolytic granule-mediated target cell killing is effected in part through the synergistic action of the membrane-acting protein p..

Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction

KM Edwards, JE Davis, KA Browne, VR Sutton, JA Trapani

Journal article  |  1999  |  Immunology and Cell Biology

Cytotoxic T cells and natural killer cells together constitute a major defence against virus infection, through their ability to i..

Fas-ligand-mediated lysis of erbB-2-expressing tumour cells by redirected cytotoxic T lymphocytes

NM Haynes, MJ Smyth, MH Kershaw, JA Trapani, PK Darcy

Journal article  |  1999  |  Cancer Immunology, Immunotherapy

Erratum: Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction (Immunology and Cell Biology (1999) 77 (76-89))

KM Edwards, JE Davis, KA Browne, VR Sutton, JA Trapani

Journal article  |  1999  |  Immunology and Cell Biology

Lymphocyte-Mediated Cytolysis: Dual Apoptotic Mechanisms with Overlapping Cytoplasmic and Nuclear Signalling Pathways

Joseph A Trapani, David A Jans

Book Chapter  |  1999  |  Results and problems in cell differentiation

Lymphocyte-mediated cytolysis: dual apoptotic mechanisms with overlapping cytoplasmic and nuclear signalling pathways.

JA Trapani, DA Jans

Journal article  |  1999  |  Results and problems in cell differentiation

A new intracellular serine protease inhibitor expressed in the rat pituitary gland complexes with granzyme B

RM Hill, KS Morresey, LC Coates, E Mezey, B Fell, T Bratt, JA Trapani, NP Birch

Journal article  |  1998  |  FEBS Letters

We have cloned a novel serpin (raPIT5a) from a rat pituitary cDNA library which is structurally related to members of the ovalbumi..

Spontaneous T cell responses to melanoma differentiation antigens from melanoma patients and healthy subjects

QY Chen, H Jackson, P Gibbs, ID Davis, J Trapani, J Cebon

Journal article  |  1998  |  Cancer Immunology, Immunotherapy

Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway

CH Bird, VR Sutton, JR Sun, CE Hirst, A Novak, S Kumar, JA Trapani, PI Bird

Journal article  |  1998  |  Molecular and Cellular Biology

Cytotoxic lymphocytes (CLs) induce caspase activation and apoptosis of target cells either through Fas activation or through relea..

Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent

JA Trapani, DA Jans, PJ Jans, MJ Smyth, KA Browne, VR Sutton

Journal article  |  1998  |  Journal of Biological Chemistry

The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations

MJ Dawson, NJ Elwood, RW Johnstone, JA Trapani

Journal article  |  1998  |  Journal of Leukocyte Biology

Nuclear targeting of the serine protease granzyme A (fragmentin-1)

DA Jans, LJ Briggs, P Jans, CJ Froelich, G Parasivam, S Kumar, VR Sutton, JA Trapani

Journal article  |  1998  |  Journal of Cell Science

Cytolytic granule-mediated target cell killing is effected in part through synergistic action of the membrane-acting protein perfo..

Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing

RW Johnstone, MH Kershaw, JA Trapani

Journal article  |  1998  |  Biochemistry

Type I IFNs enhance the terminal differentiation of dendritic cells

T Luft, KC Pang, E Thomas, P Hertzog, DNJ Hart, J Trapani, J Cebon

Journal article  |  1998  |  Journal of Immunology

The human interferon-inducible protein, IFI 16, is a repressor of transcription

RW Johnstone, JA Kerry, JA Trapani

Journal article  |  1998  |  Journal of Biological Chemistry

A serum-free culture model for studying the differentiation of human dendritic cells from adult CD34( ) progenitor cells

T Luft, KC Pang, E Thomas, CJ Bradley, H Savoia, J Trapani, J Cebon

Journal article  |  1998  |  Experimental Hematology

Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction

JA Trapani, P Jans, MJ Smyth, CJ Froelich, EA Williams, VR Sutton, DA Jans

Journal article  |  1998  |  Cell Death & Differentiation

Control of lytic function by mitogen-activated protein kinase extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: Identification of perforin and granzyme B mobilization by functional ERK2

S Wei, AM Gamero, JH Liu, AA Daulton, NI Valkov, JA Trapani, AC Larner, MJ Weber, JY Djeu

Journal article  |  1998  |  Journal of Experimental Medicine

The signal pathways that control effector function in human natural killer (NK) cells are little known. In this study, we have ide..

Expression in cytotoxic T lymphocytes of a single-chain anti-carcinoembryonic antigen antibody. Redirected Fas ligand-mediated lysis of colon carcinoma

PK Darcy, MH Kershaw, JA Trapani, MJ Smyth

Journal article  |  1998  |  European Journal of Immunology

Adoptive transfer: The role of perforin in mouse cytotoxic T lymphocyte rejection of human tumor xenografts in vivo

MJ Smyth, MH Kershaw, PK Darcy, JA Trapani