Patrick Sexton

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M-1 mAChR: The Determinants of Allosteric Activity

Manuela Jorg, Emma T van der Westhuizen, Elham Khajehali, Wessel AC Burger, Jonathan M White, Kwok HC Choy, Andrew B Tobin, Patrick M Sexton, Celine Valant, Ben Capuano, Arthur Christopoulos, Peter J Scammells

Journal article  |  2019  |  ACS Chemical Neuroscience

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Anna Ostrovskaya, Caroline Hick, Dana S Hutchinson, Brett W Stringer, Peter J Wookey, Denise Wootten, Patrick M Sexton, Sebastian GB Furness

Journal article  |  2019  |  BMC Cancer

Muscarinic M-5 receptors modulate ethanol seeking in rats

Alice E Berizzi, Christina J Perry, David M Shackleford, Craig W Lindsley, Carrie K Jones, Nicola A Chen, Patrick M Sexton, Arthur Christopoulos, Christopher J Langmead, Andrew J Lawrence

Journal article  |  2018  |  Neuropsychopharmacology

Interaction studies of multiple binding sites on M-4 muscarinic acetylcholine receptors

Alfred A Lanzafame, Patrick M Sexton, Arthur Christopoulos

Journal article  |  2006  |  Molecular Pharmacology

Effects of urea pretreatment on the binding properties of adenosine A(1) receptors

LT May, PM Sexton, A Christopoulos

Journal article  |  2005  |  British Journal of Pharmacology

G-Protein-coupled receptor-protein interactions: Basis for new concepts on receptor structure and function

Nanda Tilakaratne, Patrick M Sexton

Journal article  |  2005  |  Clinical and Experimental Pharmacology and Physiology

Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling

V Pham, MQ Dong, JD Wade, LJ Miller, CJ Morton, H Ng, MW Parker, PM Sexton

Journal article  |  2005  |  Journal of Biological Chemistry

Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2

TD Werry, KJ Gregory, PM Sexton, A Christopoulos

Journal article  |  2005  |  Journal of Neurochemistry

Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes

DL Hay, G Christopoulos, A Christopoulos, DR Poyner, PM Sexton

Journal article  |  2005  |  Molecular Pharmacology

(G)-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor

E Kostenis, G Milligan, A Christopoulos, CF Sanchez-Ferrer, S Heringer-Walther, PM Sexton, F Gembardt, E Kellett, L Martini, P Vanderheyden, HP Schultheiss, T Walther

Journal article  |  2005  |  Circulation

Peptide-oligonucleotide hybrids in antisense therapy

TL Pierce, AR White, GW Tregear, PM Sexton

Journal article  |  2005  |  Mini-Reviews in Medicinal Chemistry

Regulation of M-2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators

LT May, Y Lin, PM Sexton, A Christopoulos

Journal article  |  2005  |  Journal of Pharmacology and Experimental Therapeutics

Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-KI cells determined by microphysiometry

ET Van Der Westhuizen, PM Sexton, RAD Bathgate, RJ Summers

Conference Proceedings  |  2005  |  Annals of The New York Academy of Sciences

'Ins and outs' of seven-transmembrane receptor signalling to ERK

TD Werry, PM Sexton, A Christopoulos

Journal article  |  2005  |  Trends in Endocrinology and Metabolism

Mini ReviewCalcitonin

David M Findlay, Patrick M Sexton

Journal article  |  2004  |  Growth Factors

Amylin receptors: molecular composition and pharmacology

DL Hay, G Christopoulos, A Christopoulos, PM Sexton

Journal article  |  2004  |  Biochemical Society Transactions

G-protein-coupled receptor allosterism: the promise and the problem(s)

A Christopoulos, LT May, VA Avlani, PM Sexton

Conference Proceedings  |  2004  |  Biochemical Society Transactions

Regulation of serotonin 5-HT2C receptors by chronic ligand exposure

MG Devlin, NJ Smith, OM Ryan, E Guida, PM Sexton, A Christopoulos

Journal article  |  2004  |  European Journal of Pharmacology

Hematological defects in the oc/oc mouse, a model of infantile malignant osteopetrosis

C Blin-Wakkach, A Wakkach, PM Sexton, N Rochet, GF Carle

Journal article  |  2004  |  Leukemia

In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain

G Paxinos, SY Chai, G Christopoulos, XF Huang, AW Toga, HQ Wang, PM Sexton

Journal article  |  2004  |  Journal of Chemical Neuroanatomy

The receptor activity modifying protein family of G protein coupled receptor accessory proteins

M Udawela, DL Hay, PM Sexton

Journal article  |  2004  |  Seminars in Cell & Developmental Biology

Photoaffinity scanning in the mapping of the peptide receptor interface of class II G protein-coupled receptors.

VI Pham, Patrick M Sexton

Journal article  |  2004  |  Journal of Peptide Science

The family of G protein-coupled receptors constitutes about 50% of the therapeutic drug targets used in clinical medicine today, a..

Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors

V Avlani, LT May, PM Sexton, A Christopoulos

Journal article  |  2004  |  Journal of Pharmacology and Experimental Therapeutics

Spatial proximity between a photolabile residue in position 19 of salmon calcitonin and the amino terminus of the human calcitonin receptor

V Pham, JD Wade, BW Purdue, PM Sexton

Journal article  |  2004  |  Journal of Biological Chemistry

Allosteric modulation of G protein-coupled receptors

LT May, VA Avlani, PM Sexton, A Christopoulos

Journal article  |  2004  |  Current Pharmaceutical Design

RAMPs: 5 years on, where to now?

M Morfis, A Christopoulos, PM Sexton

Journal article  |  2003  |  Trends in Pharmacological Sciences

Novel receptor partners and function of receptor activity-modifying proteins

A Christopoulos, G Christopoulos, M Morfis, M Udawela, M Laburthe, A Couvineau, K Kuwasako, N Tilakaratne, PM Sexton

Journal article  |  2003  |  Journal of Biological Chemistry

Application of photoaffinity crosslinking in determining the interaction between calcitonin and its receptor

V Pham, JD Wade, PM Sexton

Journal article  |  2003  |  Letters in Peptide Science

Encyclopedia of Hormones

DM FINDLAY, PM SEXTON

Scholarly edition  |  2003

International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors

DR Poyner, PM Sexton, I Marshall, DM Smith, R Quirion, W Born, R Muff, JA Fischer, SM Foord

Journal article  |  2002  |  Pharmacological Reviews

Molecular Pharmacology of the Calcitonin Receptor

BW Purdue, N Tilakaratne, PM Sexton

Journal article  |  2002  |  Receptors and Channels

Receptor activity modifying proteins.

PM Sexton, A Albiston, M Morfis, N Tilakaratne

Journal article  |  2001  |  Cellular Signaling

Our understanding of G protein-coupled receptor (GPCR) function has recently expanded to encompass novel protein interactions that..