Patrick Sexton

Structure and dynamics of the active Gs-coupled human secretin receptor.

Maoqing Dong, Giuseppe Deganutti, Sarah J Piper, Yi-Lynn Liang, Maryam Khoshouei, Matthew J Belousoff, Kaleeckal G Harikumar, Christopher A Reynolds, Alisa Glukhova, Sebastian GB Furness, Arthur Christopoulos, Radostin Danev, Denise Wootten, Patrick M Sexton, Laurence J Miller

Journal article  |  2020  |  Nature Communications

The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascu..

In the Loop: Extrastriatal Regulation of Spiny Projection Neurons by GPR52

Daisy L Spark, Miaomiao Mao, Sherie Ma, Mohsin Sarwar, Cameron J Nowell, David M Shackleford, Patrick M Sexton, Jess Nithianantharajah, Gregory D Stewart, Christopher J Langmead

Journal article  |  2020  |  ACS Chemical Neuroscience

GPR52 is a Gαs-coupled orphan receptor identified as a putative target for the treatment of schizophrenia. The unique expression a..

Automatic local resolution-based sharpening of cryo-EM maps

Erney Ramirez-Aportela, Jose Luis Vilas, Alisa Glukhova, Roberto Melero, Pablo Conesa, Marta Martinez, David Maluenda, Javier Mota, Amaya Jimenez, Javier Vargas, Roberto Marabini, Patrick M Sexton, Jose Maria Carazo, Carlos Oscar S Sorzano

Journal article  |  2020  |  Bioinformatics

MOTIVATION: Recent technological advances and computational developments have allowed the reconstruction of Cryo-Electron Microsco..

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M-1 mAChR: The Determinants of Allosteric Activity

Manuela Jorg, Emma T van der Westhuizen, Elham Khajehali, Wessel AC Burger, Jonathan M White, Kwok HC Choy, Andrew B Tobin, Patrick M Sexton, Celine Valant, Ben Capuano, Arthur Christopoulos, Peter J Scammells

Journal article  |  2019  |  ACS Chemical Neuroscience

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Anna Ostrovskaya, Caroline Hick, Dana S Hutchinson, Brett W Stringer, Peter J Wookey, Denise Wootten, Patrick M Sexton, Sebastian GB Furness

Journal article  |  2019  |  BMC Cancer

Structural insights into G-protein-coupled receptor allostery

David M Thal, Alisa Glukhova, Patrick M Sexton, Arthur Christopoulos

Journal article  |  2018  |  Nature

Muscarinic M-5 receptors modulate ethanol seeking in rats

Alice E Berizzi, Christina J Perry, David M Shackleford, Craig W Lindsley, Carrie K Jones, Nicola A Chen, Patrick M Sexton, Arthur Christopoulos, Christopher J Langmead, Andrew J Lawrence

Journal article  |  2018  |  Neuropsychopharmacology

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex

Yi-Lynn Liang, Maryam Khoshouei, Alisa Glukhova, Sebastian GB Furness, Peishen Zhao, Lachlan Clydesdale, Cassandra Koole, Tin T Truong, David M Thal, Saifei Lei, Mazdak Radjainia, Radostin Danev, Wolfgang Baumeister, Ming-Wei Wang, Laurence J Miller, Arthur Christopoulos, Patrick M Sexton, Denise Wootten

Journal article  |  2018  |  Nature

Interaction studies of multiple binding sites on M-4 muscarinic acetylcholine receptors

Alfred A Lanzafame, Patrick M Sexton, Arthur Christopoulos

Journal article  |  2006  |  Molecular Pharmacology

Effects of urea pretreatment on the binding properties of adenosine A(1) receptors

LT May, PM Sexton, A Christopoulos

Journal article  |  2005  |  British Journal of Pharmacology