Prof Stephen Harrap

Since 1995 Stephen Harrap has been Professor of Physiology in the Department of Physiology at the University of Melbourne. He was Head of Physiology from 1996-2009 and Chairman of the Biomedical Sciences Academic Centre (now School of Biomedical Sciences) from 2013-4.

He is also a visiting specialist physician at the Royal Melbourne Hospital. He has long-standing research interests in the genetics of hypertension and related cardiovascular conditions. His early experimental work demonstrated the genetic linkage of abnormal renin-dependent kidney phenotypes in prehypertensive spontaneously hypertensive rats (SHR) and he discovered that short-term ACE inhibition resulted in life-long blood pressure reduction in SHR. His early breeding studies identified genetic loci influencing cardiac size independent of blood pressure and he created a novel polygenic model of human cardiac hypertrophy and heart failure; the Hypertrophic Heart Rat, which is providing new cellular and genetic paradigms for this common human problem. His human studies in the Ladywell Study and the Victorian Family Heart Study have provided unique insights into the genetics and systems biology of genetic predisposition to high blood pressure. Among his discoveries was the first association of the human Y chromosome and blood pressure. He has also plays a major role in to multinational clinical trials of stroke prevention (PROGRESS) and cardiovascular protection in diabetes (ADVANCE) respectively. He is on a range of professional committees, editorial boards and advisory groups. He was President of the High Blood Pressure Research Council of Australia between 2005 and 2010 and the President of the International Society of Hypertension from 2010 to 2012. In this role he places special emphasis on encouraging younger clinical scientists and researchers.

Find out more about Stephen Harrap's experience

Stephen Harrap's highlights

FEATURED Journal article

Does glyceryl trinitrate cause central sympatholytic effects? Insights from a case of baroreflex failure

Stephen Harrap's selected work

New Camkii Therapeutic Targets In Heart Failure With Preserved Ejection Fraction

Research Grant

The Risks of Cardiovascular Disease and Mortality Following Weight Change in Adults with D..

Journal article

Y Chromosome Mechanisms In Coronary Artery Disease

Research Grant

Change in Blood Pressure Variability Among Treated Elderly Hypertensive Patients and Its A..

Journal article

New Strategies For Preventing Hypertension

Research Grant

The relationship between eGFR slope and subsequent risk of vascular outcomes and all-cause..

Journal article

Projects

Displaying the 22 most recent projects by Stephen Harrap.

New Camkii Therapeutic Targets In Heart Failure With Preserved Ejection Fraction

Deaths associated with impaired heart muscle relaxation and unstable cardiac cycle rhythm are increasing. The mechanisms by which these path..

2017 - 2020

Active

Y Chromosome Mechanisms In Coronary Artery Disease

The Y chromosome determines sex in men and until recently was not thought to contribute to heart disease. We previously found a specific typ..

2017 - 2019

Completed

New Strategies For Preventing Hypertension

Treatment for high blood pressure was once thought to be life-long. However, there is irrefutable experimental evidence that the right treat..

2016 - 2019

Completed

New Strategies For Preventing Hypertension

Treatment for high blood pressure was once thought to be life-long. However, there is irrefutable experimental evidence that the right treat..

2016 - 2018

Completed

Local Cardiac Sex Steroids - New Therapeutic Targets

The sex hormones, estrogen and testosterone, are implicated in susceptibility to heart diseases - the timing and type of disease development..

2016 - 2019

Completed

Local Cardiac Sex Steroids - New Therapeutic Targets

The sex hormones, estrogen and testosterone, are implicated in susceptibility to heart diseases - the timing and type of disease development..

2016 - 2019

Completed

Excellence In Noncommunicable Disease Research (Encore) Between Australia And India

2015 - 2019

Completed

Animal Services Provided By Deakin University - Supply Of Services Agreement.

2012 - 2013

Completed

Novel Genetic Strategies For Heart Disease

A big heart is bad news, no matter what the cause. Sometimes this happens when the heart is under stress. At other times no cause can be fou..

2012 - 2015

Completed

New Genetic Approaches For Heart Disease

2011 - 2012

Completed

Linking Early Heart Growth Abnormality With Later Cardiac Disease Development.

An enlarged heart at maturity is a major risk factor. The goal of this project is to understand how cardiac growth abnormality in the neonat..

2010 - 2013

Completed

Genes Of The Renin-Angiotensin System And Their Association With Blood Pressure And Cardiovascular Disease

The core of our program is the training of graduate students to be productive team members, not just research subordinates. Current postgrad..

2010 - 2011

Completed

Explaining Elevated Risk For Early Heart Disease In Psychosis

The overarching goal of my research is to provide a better understanding of the processes that determine atmospheric composition and drive a..

2010 - 2011

Completed

Understanding Enlargement Of The Heart

As many as one in ten healthy individuals have hearts that are bigger than normal. Careful scientific investigation has revealed that the bi..

2007 - 2008

Completed

Genes Determining Postural Blood Pressure Responses

2007 - 2008

Completed

Identificatin Of Dna Variation On Chromosome 16p12 Responsible For The Control Of Blood Pressure

Melbourne Research Grant Support Scheme 2014 - Molecular Programming Of The Development And Prevention Of Hypertension

Finding The Genes Driving Alcohol Consumption - An Experimental Approach

Multiphoton Microscope - Neuroscience Core Facility

A Paradigm Of Genomic Discovery - An Investigation Of The Allelic Architecture Of Height

Understanding the complexities of the human body from its DNA sequence has proven difficult. Genomic discovery is best developed using stabl..

Linkage And Association Analyses Of A Locus On Chromosome 4 That Contributes To Population Variation In Hdl Cholesterol

High-density lipoprotein (HDL) cholesterol is also known as good cholesterol becuase it helps remove cholesterol from the body. Many studies..

Angiotensin Receptor Gene Polymorphism And Human Heart Size

22

Projects

Project Types

Research Grant

Internal Research Grant

Research Contracts

Scholarly Works

Displaying the 340 most recent scholarly works by Stephen Harrap.

Does glyceryl trinitrate cause central sympatholytic effects? Insights from a case of baroreflex failure

Sarah Tan, Lin Xie, Robert Anderson, Andrew Hammond, Angelina Y Fong, Seok Lim, Andrew M Allen, Stephen B Harrap

Journal article | 2020 | Internal Medicine Journal

Whether part of the blood pressure lowering effects of glyceryl trinitrate (GTN) is the result of centrally mediated reduction in ..

The Risks of Cardiovascular Disease and Mortality Following Weight Change in Adults with Diabetes: Results from ADVANCE.

Alexandra K Lee, Mark Woodward, Dan Wang, Toshiaki Ohkuma, Bethany Warren, A Richey Sharrett, Bryan Williams, Michel Marre, Pavel Hamet, Stephen Harrap, John W Mcevoy, John Chalmers, Elizabeth Selvin

Journal article | 2020 | The Journal of Clinical Endocrinology & Metabolism

CONTEXT: Weight loss is strongly recommended for overweight and obese adults with type 2 diabetes. Unintentional weight loss is as..

Change in Blood Pressure Variability Among Treated Elderly Hypertensive Patients and Its Association With Mortality.

Enayet K Chowdhury, Mark R Nelson, Lindon MH Wing, Garry LR Jennings, Lawrence J Beilin, Christopher M Reid, undefined Second Australian National Blood Pressure Study Group †, undefined Second Australian National Blood Pressure Study Group <xref ref-type="author-note" rid="jah34572-note-1001"><sup>†</sup></xref>

Journal article | 2019 | Journal of the American Heart Association

Background Information is scarce regarding effects of antihypertensive medication on blood pressure variability (BPV) and associat..

The relationship between eGFR slope and subsequent risk of vascular outcomes and all-cause mortality in type 2 diabetes: the ADVANCE-ON study

Megumi Oshima, Min Jun, Toshiaki Ohkuma, Tadashi Toyama, Takashi Wada, Mark E Cooper, Samy Hadjadj, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Michel Marre, Bryan Williams, John Chalmers, Mark Woodward, Vlado Perkovic

Journal article | 2019 | Diabetologia

AIMS/HYPOTHESIS: Some studies have reported that annual change in eGFR (eGFR slope) is associated with the future risk of end-stag..

Response of 1,5-anhydroglucitol level to intensive glucose- and blood-pressure lowering interventions, and its associations with clinical outcomes in the ADVANCE trial

Elizabeth Selvin, Dan Wang, John William McEvoy, Stephen P Juraschek, Mariana Lazo, Pavel Hamet, Mark E Cooper, Michel Marre, Bryan Williams, Stephen Harrap, John Chalmers, Mark Woodward

Journal article | 2019 | Diabetes, Obesity and Metabolism

Combination of Changes in Estimated GFR and Albuminuria and the Risk of Major Clinical Outcomes

Toshiaki Ohkuma, Min Jun, John Chalmers, Mark E Cooper, Pavel Hamet, Stephen Harrap, Sophia Zoungas, Vlado Perkovic, Mark Woodward

Journal article | 2019 | Clinical Journal of the American Society of Nephrology

BACKGROUND AND OBJECTIVES: Whether combining changes in eGFR and urine albumin-to-creatinine ratio (UACR) is more strongly associa..

Effects of Blood Pressure Lowering on Clinical Outcomes According to Baseline Blood Pressure and Cardiovascular Risk in Patients With Type 2 Diabetes Mellitus: The ADVANCE Trial

Faisal Rahman, John W McEvoy, Yoshiaki Ohkuma, Michel Marre, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Anthony Rodgers, Elizabeth Selvin, Bryan Williams, Paul Muntner, John Chalmers, Mark Woodward

Journal article | 2019 | Hypertension

EPHA4 regulates vascular smoothmuscle cell contractility and is a sex-specific hypertension risk gene in individuals with type 2 diabetes

Zeqin Zhang, Johanne Tremblay, John Raelson, Tamar Sofer, Lizhong Du, Qiang Fang, Maria Argos, Francois-Christophe Marois-Blanchet, Yu Wang, Lingling Yan, John Chalmers, Mark Woodward, Stephen Harrap, Pavel Hamet, Hongyu Luo, Jiangping Wu

Journal article | 2019 | Journal of Hypertension

New Blood Pressure Guidelines Pose Difficult Choices for Australian Physicians

Stephen B Harrap, Thomas Lung, John Chalmers

Journal article | 2019 | Circulation Research

Genetics of obesity in consanguineous populations - A road map to provide novel insights in the molecular basis and management of obesity

Nitin Kapoor, Aaron Chapla, John Furler, Thomas V Paul, Stephen Harrap, Brian Oldenburg, Nihal Thomas

Journal article | 2019 | EBioMedicine

Acute Increases in Serum Creatinine After Starting Angiotensin-Converting Enzyme Inhibitor-Based Therapy and Effects of its Continuation on Major Clinical Outcomes in Type 2 Diabetes Mellitus: The ADVANCE Trial

Toshiaki Ohkuma, Min Jun, Anthony Rodgers, Mark E Cooper, Paul Glasziou, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Michel Marre, Bruce Neal, Vlado Perkovic, Neil Poulter, Bryan Williams, Sophia Zoungas, John Chalmers, Mark Woodward

Journal article | 2019 | Hypertension

CIRCULAR RNAS HRCR AND CTTN ARE UPREGULATED IN THE HYPERTROPHIC HEART INDEPENDENT OF BLOOD PRESSURE

Priscilla Prestes, Stephen Harrap, Fadi Charchar

Conference Proceedings | 2018 | JOURNAL OF HYPERTENSION

CIRCULAR RNA EXPRESSION IS RESET BY BRIEF ANTIHYPERTENSIVE TREATMENT IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR)

Priscilla Prestes, Nathan De Vries, Sean Byars, Andrew Allen, Stephen Harrap, Fadi Charchar

Conference Proceedings | 2018 | JOURNAL OF HYPERTENSION

ANGIOTENSIN CONVERTING ENZYME INHIBITORS EPIGENETICALLY ATENUATE TELOMERE SHORTENING

Nathan De Vries, Priscilla Prestes, Mukesh Raipuria, Sean Byars, Andrew Allen, Stephen Harrap, Fadi Charchar

Conference Proceedings | 2018 | Journal of Hypertension

Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy

PR Prestes, FZ Marques, G Lopez-Campos, P Lewandowski, LMD Delbridge, FJ Charchar, SB Harrap

Journal article | 2018 | Physiological Genomics

Cardiac function in pregnancy

Dominica Zentner, Stephen Brian Harrap

Journal article | 2018 | Journal of Hypertension

Use of the waist-to-height ratio to predict cardiovascular risk in patients with diabetes: Results from the ADVANCE-ON study

Karin Radholm, John Chalmers, Toshiaki Ohkuma, Sanne Peters, Neil Poulter, Pavel Hamet, Stephen Harrap, Mark Woodward

Journal article | 2018 | Diabetes, Obesity and Metabolism

Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive-A New Preclinical Model

Claire L Curl, Vennetia R Danes, James R Bell, Antonia JA Raaijmakers, Wendy TK Ip, Chanchal Chandramouli, Tristan W Harding, Enzo R Porrello, Jeffrey R Erickson, Fadi J Charchar, Andrew R Kompa, Amanda J Edgley, David J Crossman, Christian Soeller, Kimberley M Mellor, Jonathan M Kalman, StephenB Harrap, Lea MD Delbridge

Journal article | 2018 | Journal of the American Heart Association

Pericardial adipose and aromatase: A new translational target for aging, obesity and arrhythmogenesis?

Gabriel B Bernasochi, Wah Chin Boon, Claire L Curl, Upasna Varma, Salvatore Pepe, Marianne Tare, Laura J Parry, Evdokia Dimitriadis, Stephen B Harrap, Chrishan J Nalliah, Jonathan M Kalman, Lea MD Delbridge, James R Bell

Journal article | 2017 | Journal of Molecular and Cellular Cardiology

Cardiac Stress and Inflammatory Markers as Predictors of Heart Failure in Patients With Type 2 Diabetes: The ADVANCE Trial.

Toshiaki Ohkuma, Min Jun, Mark Woodward, Sophia Zoungas, Mark E Cooper, Diederick E Grobbee, Pavel Hamet, Giuseppe Mancia, Bryan Williams, Paul Welsh, Naveed Sattar, Jonathan E Shaw, Kazem Rahimi, John Chalmers, undefined ADVANCE Collaborative Group

Journal article | 2017 | Diabetes Care

OBJECTIVE: This study examined the individual and combined effect of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-s..

Prognostic Value of Variability in Systolic Blood Pressure Related to Vascular Events and Premature Death in Type 2 Diabetes Mellitus The ADVANCE-ON Study

Toshiaki Ohkuma, Mark Woodward, Min Jun, Paul Muntner, Jun Hata, Stephen Colagiuri, Stephen Harrap, Giuseppe Mancia, Neil Poulter, Bryan Williams, Peter Rothwell, John Chalmers

Journal article | 2017 | Hypertension

Comparative effects of microvascular and macrovascular disease on the risk of major outcomes in patients with type 2 diabetes

Kamel Mohammedi, Mark Woodward, Michel Marre, Stephen Colagiuri, Mark Cooper, Stephen Harrap, Giuseppe Mancia, Neil Poulter, Bryan Williams, Sophia Zoungas, John Chalmers

Journal article | 2017 | Cardiovascular Diabetology

Genetics of blood pressure: time to curate the collection

Stephen B Harrap, Fadi J Charchar

Journal article | 2017 | Journal of Hypertension

Side effects and tolerability of combination blood pressure lowering according to blood pressure levels: an analysis of the PROGRESS and ADVANCE trials

Emily R Atkins, Yoichiro Hirakawa, Abdul Salam, Mark Woodward, Mark Cooper, Pavel Hamet, Stephen Harrap, Kennedy Lees, Lisheng Liu, Giuseppe Mancia, Michel Marre, Vlado Perkovic, Neil Poulter, Bryan Williams, John Chalmers, Anthony Rodgers

Journal article | 2017 | Journal of Hypertension

Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

Francine Z Marques, Priscilla R Prestes, Sean G Byars, Scott C Ritchie, Peter Wurtz, Sheila K Patel, Scott A Booth, Indrajeetsinh Rana, Yosuke Minoda, Stuart P Berzins, Claire L Curl, James R Bell, Bryan Wai, Piyush M Srivastava, Antti J Kangas, Pasi Soininen, Saku Ruohonen, Mika Kahonen, Terho Lehtimaki, Emma Raitoharju, et al.

Journal article | 2017 | Journal of the American Heart Association

Familial Analysis of Epistatic and Sex-Dependent Association of Genes of the Renin-Angiotensin-Aldosterone System and Blood Pressure

Katrina J Scurrah, Angela Lamantia, Justine A Ellis, Stephen B Harrap

Journal article | 2017 | Circulation: Cardiovascular Genetics

The impact of level of education on vascular events and mortality in patients with type 2 diabetes mellitus: Results from the ADVANCE study

JI Blomster, S Zoungas, M Woodward, B Neal, S Harrap, N Poulter, M Marre, B Williams, J Chalmers, GS Hillis

Journal article | 2017 | Diabetes Research and Clinical Practice

PROX1 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study

Pavel Hamet, Mounsif Haloui, Francois Harvey, Francois-Christophe Marois-Blanchet, Marie-Pierre Sylvestre, Muhammad-Ramzan Tahir, Paul HG Simon, Beatriz Sonja Kanzki, John Raelson, Carole Long, John Chalmers, Mark Woodward, Michel Marre, Stephen Harrap, Johanne Tremblay

Journal article | 2017 | Journal of Hypertension

Genetic Variation in Kruppel like Factor 15 Is Associated with Left Ventricular Hypertrophy in Patients with Type 2 Diabetes: Discovery and Replication Cohorts

Sheila K Patel, Bryan Wai, Chim C Lang, Daniel Levin, Colin NA Palmer, Helen M Parry, Elena Velkoska, Stephen B Harrap, Piyush M Srivastava, Louise M Burrell

Journal article | 2017 | EBioMedicine

Evidence from single nucleotide polymorphism analyses of ADVANCE study demonstrates EFNB3 as a hypertension risk gene

Johanne Tremblay, Yujia Wang, John Raelson, Francois-Christophe Marois-Blanchet, Zenghui Wu, Hongyu Luo, Edward Bradley, John Chalmers, Mark Woodward, Stephen Harrap, Pavel Hamet, Jiangping Wu

Journal article | 2017 | Scientific Reports

Reduced blood pressure after smooth muscle EFNB2 deletion and the potential association of EFNB2 mutation with human hypertension risk

Yujia Wang, Pavel Hamet, Eric Thorin, Johanne Tremblay, John Raelson, Zenghui Wu, Hongyu Luo, Wei Jin, Julie L Lavoie, Junzheng Peng, Francois-Christophe Marois-Blanchet, Muhammad Ramzan Tahir, John Chalmers, Mark Woodward, Stephen Harrap, Shijie Qi, Charles Yibin Li, Jiangping Wu

Journal article | 2016 | European Journal of Human Genetics

Estimation of individual beneficial and adverse effects of intensive glucose control for patients with type 2 diabetes

Joep van der Leeuw, Frank LJ Visseren, Mark Woodward, Yolanda van der Graaf, Diederick E Grobbee, Stephen Harrap, Simon Heller, Giuseppe Mancia, Michel Marre, Neil Poulter, Sophia Zoungas, John Chalmers

Journal article | 2016 | Diabetologia

Absence of Peripheral Pulses and Risk of Major Vascular Outcomes in Patients With Type 2 Diabetes

Kamel Mohammedi, Mark Woodward, Sophia Zoungas, Qiang Li, Stephen Harrap, Anushka Patel, Michel Marre, John Chalmers

Journal article | 2016 | Diabetes Care

Microvascular and Macrovascular Disease and Risk for Major Peripheral Arterial Disease in Patients With Type 2 Diabetes

Kamel Mohammedi, Mark Woodward, Yoichiro Hirakawa, Sophia Zoungas, Bryan Williams, Lisheng Liu, Anthony Rodgers, Giuseppe Mancia, Bruce Neal, Stephen Harrap, Michel Marre, John Chalmers

Journal article | 2016 | Diabetes Care

Presentations of major peripheral arterial disease and risk of major outcomes in patients with type 2 diabetes: results from the ADVANCE-ON study

Kamel Mohammedi, Mark Woodward, Yoichiro Hirakawa, Sophia Zoungas, Stephen Colagiuri, Pavel Hamet, Stephen Harrap, Neil Poulter, David R Matthews, Michel Marre, John Chalmers

Journal article | 2016 | Cardiovascular Diabetology

OS 05-01 PROX1 GENE CC GENOTYPE AS A MAJOR DETERMINANT OF EARLY ONSET OF T2D AND CARDIOVASCULAR COMPLICATIONS IN SLAVIC SUBJECTS FROM ADVANCE STUDY.

P Hamet, M Haloui, F Harvey, FC Marois-Blanchet, P Simon, J Raelson, M Phillips, J Chalmers, M Woodward, M Marre, S Harrap, J Tremblay

Journal article | 2016 | Journal of Hypertension

OBJECTIVE: We have previously reported distinct genetic architectures of renal impairment in T2D patients of Slavic and Celtic ori..

PATHOPHYSIOLOGIC SIGNIFICANCE OF NON-CODING RNA IN HYPERTENSION

Stephen Harrap

Conference Proceedings | 2016 | JOURNAL OF HYPERTENSION

EPISTATIC AND SEX-DEPENDENT ASSOCIATION ANALYSES OF GENES OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM AND BLOOD PRESSURE IN FAMILIES

Stephen Harrap, Katrina Scurrah, Angela Lamantia, Justine Ellis

Conference Proceedings | 2016 | JOURNAL OF HYPERTENSION

BLOOD PRESSURE, INITIAL ORTHOSTATIC HYPOTENSION, GLYCERYL TRINITRATE AND THE GLU504LYS POLYMORPHISM OF ALDEHYDE DEHYROGENASE-2

Stephen Harrap, Angela Lamantia, James Ziogas, Jane Bourke

Conference Proceedings | 2016 | JOURNAL OF HYPERTENSION

OS 31-01 BLOOD PRESSURE, INITIAL ORTHOSTATIC HYPOTENSION, GLYCERYL TRINITRATE AND THE GLU504LYS POLYMORPHISM OF ALDEHYDE DEHYROGENASE-2.

S Harrap, A Lamantia, J Ziogas, J Bourke

Journal article | 2016 | Journal of Hypertension

OBJECTIVE: Glyceryl trinitrate (GTN) is used to treat angina and lower blood pressure. The enzyme mitochondrial aldehyde dehydroge..

OS 31-01 BLOOD PRESSURE, INITIAL ORTHOSTATIC HYPOTENSION, GLYCERYL TRINITRATE AND THE GLU504LYS POLYMORPHISM OF ALDEHYDE DEHYROGENASE-2.

Stephen Harrap, Angela Lamantia, James Ziogas, Jane Bourke

Journal article | 2016 | J Hypertens

OBJECTIVE: Glyceryl trinitrate (GTN) is used to treat angina and lower blood pressure. The enzyme mitochondrial aldehyde dehydroge..

YIA 03-04 EPIGENETIC CHANGES AFTER ACUTE TREATMENT WITH ACUTE ANGIOTENSIN CONVERTING ENZYME INHIBITORS (ACEi).

N De Vries, P Prestes, I Rana, SB Harrap, FJ Charchar

Journal article | 2016 | Journal of Hypertension

OBJECTIVE: The 'legacy effect' of hypertension treatment is where short term treatment with blood pressure (BP) lowering drugs suc..

YIA 03-04 EPIGENETIC CHANGES AFTER ACUTE TREATMENT WITH ACUTE ANGIOTENSIN CONVERTING ENZYME INHIBITORS (ACEi).

Nathan De Vries, Priscilla Prestes, Indrajeet Rana, Stephen B Harrap, Fadi J Charchar

Journal article | 2016 | J Hypertens

OBJECTIVE: The 'legacy effect' of hypertension treatment is where short term treatment with blood pressure (BP) lowering drugs suc..

THE EFFECT OF GENES INVOLVED IN MONOGENIC HUMAN CARDIOMYOPATHIES IN A POLYGENIC MODEL OF CARDIAC HYPERTROPHY

Priscilla Prestes, Francine Marques, Claire Curl, Paul Lewandowski, Lea Delbridge, Stephen Harrap, Fadi Charchar

Conference Proceedings | 2016 | Journal of Hypertension

OS 05-01 PROX1 GENE CC GENOTYPE AS A MAJOR DETERMINANT OF EARLY ONSET OF T2D AND CARDIOVASCULAR COMPLICATIONS IN SLAVIC SUBJECTS FROM ADVANCE STUDY.

Pavel Hamet, Mounsif Haloui, François Harvey, François-Christophe Marois-Blanchet, Paul Simon, John Raelson, Michael Phillips, John Chalmers, Mark Woodward, Michel Marre, Stephen Harrap, Johanne Tremblay

Journal article | 2016 | J Hypertens

OBJECTIVE: We have previously reported distinct genetic architectures of renal impairment in T2D patients of Slavic and Celtic ori..

EPIGENETIC CHANGES AFTER ACUTE TREATMENT WITH ACUTE ANGIOTENSIN CONVERTING ENZYME INHIBITORS (ACEI)

Nathan De Vries, Priscilla Prestes, Indrajeet Rana, Stephen B Harrap, Fadi J Charchar

Conference Proceedings | 2016 | JOURNAL OF HYPERTENSION

PROX1 GENE CC GENOTYPE AS A MAJOR DETERMINANT OF EARLY ONSET OF T2D AND CARDIOVASCULAR COMPLICATIONS IN SLAVIC SUBJECTS FROM ADVANCE STUDY

Pavel Hamet, Mounsif Haloui, Francois Harvey, Francois-Christophe Marois-Blanchet, Paul Simon, John Raelson, Michael Phillips, John Chalmers, Mark Woodward, Michel Marre, Stephen Harrap, Johanne Tremblay

Conference Proceedings | 2016 | JOURNAL OF HYPERTENSION

Male and female hypertrophic rat cardiac myocyte functional responses to ischemic stress and beta-adrenergic challenge are different

James R Bell, Claire L Curl, Tristan W Harding, Martin Vila Petroff, Stephen B Harrap, Lea MD Delbridge

Journal article | 2016 | Biology of Sex Differences

Socioeconomic position in young adulthood is associated with BMI in Australian families

Katrina J Scurrah, Anne M Kavanagh, Rebecca J Bentley, Lukar E Thornton, Stephen B Harrap

Journal article | 2016 | Journal of Public Health

Long-term Benefits of Intensive Glucose Control for Preventing End-Stage Kidney Disease: ADVANCE-ON

Muh Geot Wong, Vlado Perkovic, John Chalmers, Mark Woodward, Qiang Li, Mark E Cooper, Pavel Hamet, Stephen Harrap, Simon Heller, Stephen MacMahon, Giuseppe Mancia, Michel Marre, David Matthews, Bruce Neal, Neil Poulter, Anthony Rodgers, Bryan Williams, Sophia Zoungas

Journal article | 2016 | Diabetes Care

The Role of miR-378*, miR-218 & miR-351 in Cardiac Hypertrophy

Shahzad Sadiq, Fadij Charchar, Tamsyn Crowley, Lea Delbridge, Stephen Harrap, Paul Lewandowski

Conference Proceedings | 2016 | FASEB JOURNAL

Risks associated with permanent discontinuation of blood pressure-lowering medications in patients with type 2 diabetes

Yoichiro Hirakawa, Hisatomi Arima, Ruth Webster, Sophia Zoungas, Qiang Li, Stephen Harrap, Lisheng Liu, Pavel Hamet, Giuseppe Mancia, Neil Poulter, Bruce Neal, Bryan Williams, Anthony Rogers, Mark Woodward, John Chalmers

Journal article | 2016 | Journal of Hypertension

Blood pressure guidelines: beyond simple targets

Stephen B Harrap

Journal article | 2016 | Cardiovascular Endocrinology

Tripartite motif-containing 55 identified as functional candidate for spontaneous cardiac hypertrophy in the rat locus cardiac mass 22.

G LOPEZ CAMPOS, PR Prestes, FZ Marques, SA Booth, M McGlynn, P Lewandowski, LM Dellbridge, SB Harrap, FJ Charchar

Journal article | 2016 | Journal of Hypertension

Changes in Quality of Life Associated with Complications of Diabetes: Results from the ADVANCE Study

Alison Hayes, Hisatomi Arima, Mark Woodward, John Chalmers, Neil Poulter, Pavel Hamet, Philip Clarke

Journal article | 2016 | Value in Health

Telomere dynamics during aging in polygenic left ventricular hypertrophy

Francine Z Marques, Scott A Booth, Priscilla R Prestes, Claire L Curl, Lea MD Delbridge, Paul Lewandowski, Stephen B Harrap, Fadi J Charchar

Journal article | 2016 | Physiological Genomics

The harms of smoking and benefits of smoking cessation in women compared with men with type 2 diabetes: an observational analysis of the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial

Juuso I Blomster, Mark Woodward, Sophia Zoungas, Graham S Hillis, Stephen Harrap, Bruce Neal, Neil Poulter, Giuseppe Mancia, John Chalmers, Rachel Huxley

Journal article | 2016 | BMJ Open

Renal Mechanisms of Association between Fibroblast Growth Factor 1 and Blood Pressure

Maciej Tomaszewski, James Eales, Matthew Denniff, Stephen Myers, Guat Siew Chew, Christopher P Nelson, Paraskevi Christofidou, Aishwarya Desai, Cara Buesst, Lukasz Wojnar, Katarzyna Musialik, Jacek Jozwiak, Radoslaw Debiec, Anna F Dominiczak, Gerjan Navis, Wiek H van Gilst, Pim van der Harst, Nilesh J Samani, Stephen Harrap, Pawel Bogdanski, et al.

Journal article | 2015 | Journal of the American Society of Nephrology

Blood Pressure Genetics Just Don't Add Up

Stephen B Harrap, Brian J Morris

Journal article | 2015 | Circulation: Cardiovascular Genetics

Non-proportional odds multivariate logistic regression of ordinal family data

Sophie G Zaloumis, Katrina J Scurrah, Stephen B Harrap, Justine A Ellis, Lyle C Gurrin

Journal article | 2015 | Biometrical Journal

Cardiac CaMKII delta splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart

James R Bell, Antonia JA Raaijmakers, Claire L Curl, Melissa E Reichelt, TristanW Harding, Aier Bei, Dominic CH Ng, Jeffrey R Erickson, Martin Vila Petroff, Stephen B Harrap, Lea MD Delbridge

Journal article | 2015 | International Journal of Cardiology

Characterizing the continuously acquired cardiovascular time series during hemodialysis, using median hybrid filter preprocessing noise reduction

Scott Wilson, Andrea Bowyer, Stephen B Harrap

Journal article | 2015 | Medical Devices: Evidence and Research

Impact of age, age at diagnosis and duration of diabetes on the risk of macrovascular and microvascular complications and death in type 2 diabetes

Sophia Zoungas, Mark Woodward, Qiang Li, Mark E Cooper, Pavel Hamet, Stephen Harrap, Simon Heller, Michel Marre, Anushka Patel, Neil Poulter, Bryan Williams, John Chalmers

Journal article | 2014 | Diabetologia

Degree of blood pressure reduction and recurrent stroke: the PROGRESS trial

Hisatomi Arima, Craig Anderson, Teruo Omae, Mark Woodward, Stephen MacMahon, Giuseppe Mancia, Marie-Germaine Bousser, Christophe Tzourio, Stephen Harrap, Lisheng Liu, Bruce Neal, John Chalmers

Journal article | 2014 | Journal of Neurology, Neurosurgery & Psychiatry

Follow-up of Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes

S Zoungas, J Chalmers, B Neal, L Billot, Q Li, Y Hirakawa, H Arima, H Monaghan, R Joshi, S Colagiuri, ME Cooper, P Glasziou, D Grobbee, P Hamet, S Harrap, S Heller, L Lisheng, G Mancia, M Marre, DR Matthews, et al.

Journal article | 2014 | New England Journal of Medicine

Do Cardiac Biomarkers NT-proBNP and hsTnT Predict Microvascular Events in Patients With Type 2 Diabetes? Results From the ADVANCE Trial

Paul Welsh, Mark Woodward, Graham S Hillis, Qiang Li, Michel Marre, Bryan Williams, Neil Poulter, Louise Ryan, Stephen Harrap, Ansuhka Patel, John Chalmers, Naveed Sattar

Journal article | 2014 | Diabetes Care

Impact of Visit-to-Visit Glycemic Variability on the Risks of Macrovascular and Microvascular Events and All-Cause Mortality in Type 2 Diabetes: The ADVANCE Trial

Yoichiro Hirakawa, Hisatomi Arima, Sophia Zoungas, Toshiharu Ninomiya, Mark Cooper, Pavel Hamet, Giuseppe Mancia, Neil Poulter, Stephen Harrap, Mark Woodward, John Chalmers

Journal article | 2014 | Diabetes Care

Whole genome and transcriptome approach in a polygenic model for cardiac hypertrophy identifies Trim55 as a new candidate gene in quantitative trait locus cardiac mass 22

PR Prestes, FZ Marques, G Lopez-Campos, SB Harrap, FJ Charchar

Conference Proceedings | 2014 | Cardiovascular Research

The involvement of genes for human hypertrophic dilated cardiomyopathy to experimental polygenic cardiac hypertrophy

P Prestes, FZ Marques, G Lopez-Campos, FJ Charchar, SB Harrap

Conference Proceedings | 2014 | Cardiovascular Research

Measurement of absolute copy number variation reveals association with essential hypertension

Francine Z Marques, Priscilla R Prestes, Leonardo B Pinheiro, Katrina Scurrah, Kerry R Emslie, Maciej Tomaszewski, Stephen B Harrap, Fadi J Charchar

Journal article | 2014 | BMC Medical Genomics

DROPLET DIGITAL PCR MEASUREMENT OF COPY NUMBER VARIATION IN GENOME-WIDE ASSOCIATION REGIONS FOR BLOOD PRESSURE REVEAL ASSOCIATION WITH ESSENTIAL HYPERTENSION

FZ Marques, PR Prestes, LB Pinheiro, K Scurrah, KR Emslie, M Tomaszewski, SB Harrap, FJ Charchar

Conference Proceedings | 2014 | HYPERTENSION

SINGLE NUCLEOTIDE POLYMORPHISM, EPISTATIC AND SEX-DEPENDENT ASSOCIATION ANALYSES OF GENES OF THE RENIN-ANGIOTENSIN SYSTEM AND BLOOD PRESSURE IN FAMILIES

KJ Scurrah, A Lamantia, JA Ellis, SB Harrap

Conference Proceedings | 2014 | HYPERTENSION

DOWN-REGULATED Ca2 /CALMODULIN-DEPENDENT KINASE II ACTIONS IN THE HYPERTROPHIC FEMALE HEART - A LIABILITY FOR ISCHEMIA/REPERFUSION ARRHYTHMIAS?

JR Bell, CL Curl, AHA Raaijmakers, TW Harding, SB Harrap, LMD Delbridge

Conference Proceedings | 2014 | HYPERTENSION

AN UNEXPECTED DICHOTOMY IN WHOLE HEART AND CARDIOMYOCYTE FUNCTION IN THE HYPERTROPHIC HEART RAT - A MODEL OF HYPERTROPHY IN THE ABSENCE OF HYPERTENSION

CL Curl, AJA Raaijmakers, CC Chandramouli, TW Harding, SB Harrap, LMD Delbridge

Conference Proceedings | 2014 | HYPERTENSION

WHOLE GENOME DNA SEQUENCING OF A GENETIC MODEL OF CARDIAC HYPERTROPHY IDENTIFIES TWO CANDIDATE GENES IN CARDIAC MASS QTL 22

PR Prestes, FZ Marques, G Lopez-Campos, SB Harrap, FJ Charchar

Conference Proceedings | 2014 | HYPERTENSION

Intensification of medication and glycaemic control among patients with type 2 diabetes - the ADVANCE trial.

S van Dieren, AP Kengne, J Chalmers, JWJ Beulens, TME Davis, G Fulcher, SR Heller, A Patel, S Colagiuri, P Hamet, G Mancia, M Marre, B Neal, B Williams, LM Peelen, YT van der Schouw, M Woodward, S Zoungas

Journal article | 2014 | Diabetes, Obesity and Metabolism

AIMS: The aim of this study was to assess associations between patient characteristics, intensification of blood glucose-lowering ..

The Relationship Between Alcohol Consumption and Vascular Complications and Mortality in Individuals With Type 2 Diabetes

Juuso I Blomster, Sophia Zoungas, John Chalmers, Qiang Li, Clara K Chow, Mark Woodward, Giuseppe Mancia, Neil Poulter, Bryan Williams, Stephen Harrap, Bruce Neal, Anushka Patel, Graham S Hillis

Journal article | 2014 | Diabetes Care

Latin American Consensus hypertension in patients with type 2 diabetes and metabolic syndrome

Patricio Lopez-Jaramillo, Ramiro A Sachez, Margarita Diaz, Leonardo Cobos, Alfonso Bryce, Jose Z Parra-Carrillo, Fernando Lizcano, Fernando Lanas, Isaac Sinay, Ivn D Sierra, Ernesto Peaherrera, Mario Bendersky, Helena Schmid, Rodrigo Botero, Manuel Urina, Joffre Lara, Milton C Foss, Gustavo Mrquez, Stephen Harrap, Agustn J Ramrez, et al.

Journal article | 2014 | Arquivos Brasileiros de Endocrinologia & Metabologia

[Latin American consensus on hypertension in patients with diabetes type 2 and metabolic syndrome].

Patricio López-Jaramillo, Ramiro A Sánchez, Margarita Díaz, Leonardo Cobos, Alfonso Bryce, José Z Parra-Carrillo, Fernando Lizcano, Fernando Lanas, Isaac Sinay, Iván D Sierra, Ernesto Peñaherrera, Mario Benderky, Helena Schmid, Rodrigo Botero, Manuel Urina, Joffre Lara, Milton C Foos, Gustavo Márquez, Stephen Harrap, Agustín J Ramírez, et al.

Journal article | 2014 | Clínica e Investigación en Arteriosclerosis

The present document has been prepared by a group of experts, members of Cardiology, Endocrinology, Internal Medicine, Nephrology ..

Circulating Inflammatory Markers and the Risk of Vascular Complications and Mortality in People With Type 2 Diabetes and Cardiovascular Disease or Risk Factors: The ADVANCE Study

Gordon Lowe, Mark Woodward, Graham Hillis, Ann Rumley, Qiang Li, Stephen Harrap, Michel Marre, Pavel Hamet, Anushka Patel, Neil Poulter, John Chalmers

Journal article | 2014 | Diabetes

The World Hypertension League and International Society of Hypertension Call on Governments, Nongovernmental Organizations, and the Food Industry to Work to Reduce Dietary Sodium

Norm Campbell, Daniel Lackland, Arun Chockalingam, Lisheng Liu, Ernesto L Schiffrin, Stephen Harrap, Rhian M Touyz, Louise Burrell, Augustin Ramirez, Roland Schmieder, Schutte Aletta, Dorairaj Prabhakaran

Journal article | 2014 | The Journal of Clinical Hypertension

Effects of Combination of Perindopril, Indapamide, and Calcium Channel Blockers in Patients With Type 2 Diabetes Mellitus Results From the Action in Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) Trial

John Chalmers, Hisatomi Arima, Mark Woodward, Giuseppe Mancia, Neil Poulter, Yoichiro Hirakawa, Sophia Zoungas, Anushka Patel, Bryan Williams, Stephen Harrap

Journal article | 2014 | Hypertension

Clinical Practice Guidelines for the Management of Hypertension in the Community A Statement by the American Society of Hypertension and the International Society of Hypertension

Michael A Weber, Ernesto L Schiffrin, William B White, Samuel Mann, Lars H Lindholm, John G Kenerson, John M Flack, Barry L Carter, Barry J Materson, C Venkata S Ram, Debbie L Cohen, Jean-Claude Cadet, Roger R Jean-Charles, Sandra Taler, David Kountz, Raymond Townsend, John Chalmers, Agustin J Ramirez, George L Bakris, Jiguang Wang, et al.

Journal article | 2014 | Journal of Hypertension

Clinical Practice Guidelines for the Management of Hypertension in the Community A Statement by the American Society of Hypertension and the International Society of Hypertension

Michael A Weber, Ernesto L Schiffrin, William B White, Samuel Mann, Lars H Lindholm, John G Kenerson, John M Flack, Barry L Carter, Barry J Materson, C Venkata S Ram, Debbie L Cohen, Jean-Claude Cadet, Roger R Jean-Charles, Sandra Taler, David Kountz, Raymond R Townsend, John Chalmers, Agustin J Ramirez, George L Bakris, Jiguang Wang, et al.

Journal article | 2014 | The Journal of Clinical Hypertension

Early Treatment to Prevent Hypertension: A Laudable Goal

Stephen B Harrap, Fadi J Charchar

Journal article | 2013 | American Journal of Hypertension

The influence of physical activity on vascular complications and mortality in patients with type 2 diabetes mellitus

JI Blomster, CK Chow, S Zoungas, M Woodward, A Patel, NR Poulter, M Marre, S Harrap, J Chalmers, GS Hillis

Journal article | 2013 | Diabetes Obesity & Metabolism

Effects of visit-to-visit variability in systolic blood pressure on macrovascular and microvascular complications in patients with type 2 diabetes mellitus: the ADVANCE trial.

Jun Hata, Hisatomi Arima, Peter M Rothwell, Mark Woodward, Sophia Zoungas, Craig Anderson, Anushka Patel, Bruce Neal, Paul Glasziou, Pavel Hamet, Giuseppe Mancia, Neil Poulter, Bryan Williams, Stephen Macmahon, John Chalmers, undefined ADVANCE Collaborative Group

Journal article | 2013 | Circulation

BACKGROUND: Recent evidence suggests that visit-to-visit variability in systolic blood pressure (SBP) and maximum SBP are predicto..

Latin American consensus on hypertension in patients with diabetes type 2 and metabolic syndrome

P López-Jaramillo, RA Sánchez, M Díaz, L Cobos, A Bryce, JZ Parra-Carrillo, F Lizcano, F Lanas, I Sinay, ID Sierra, E Peñaherrera, M Benderky, H Schmid, R Botero, M Urina, J Lara, MC Foos, G Márquez, S Harrap, AJ Ramírez, et al.

Journal article | 2013 | Anales Venezolanos de Nutricion

WHAT IS HAEMODYNAMIC STABILITY? THE IMPORTANCE OF 'TIME' IN 'CHANGE OVER TIME'

S Wilson, G Becker, S Harrap

Conference Proceedings | 2013 | NEPHROLOGY

A NOVEL METHOD TO PROFILE THE CARDIOVASCULAR STABILITY OF DIALYSIS PATIENTS BY CONTINUOUS MEASUREMENT USING A MEDIAN HYBRID PREPROCESSING FILTER ALGORITHM

S Wilson, S Harrap, G Becker

Conference Proceedings | 2013 | NEPHROLOGY

EVERY DAY IS A NEW DAY: THE CARDIOVASCULAR RESPONSE TO STANDARD IN-CENTRE HAEMODIALYSIS (HD) IS NOT CONSISTENT ACROSS SERIAL TREATMENTS

S Wilson, G Becker, S Harrap

Conference Proceedings | 2013 | NEPHROLOGY

Inflammatory markers and the risk of vascular complications and mortality in type 2 diabetes mellitus

GS Hillis, G Lowe, M Woodward, A Rumley, S Harrap, M Marre, P Hamet, A Patel, N Poulter, J Chalmers

Conference Proceedings | 2013 | EUROPEAN HEART JOURNAL

Genetic Loci for Retinal Arteriolar Microcirculation

Xueling Sim, Richard A Jensen, M Kamran Ikram, Mary Frances Cotch, Xiaohui Li, Stuart MacGregor, Jing Xie, Albert Vernon Smith, Eric Boerwinkle, Paul Mitchell, Ronald Klein, Barbara EK Klein, Nicole L Glazer, Thomas Lumley, Barbara McKnight, Bruce M Psaty, Paulus TVM de Jong, Albert Hofman, Fernando Rivadeneira, Andre G Uitterlinden, et al.

Journal article | 2013 | PLoS One

Global survey of current practice in management of hypertension as reported by societies affiliated with the international society of hypertension

John Chalmers, Hisatomi Arima, Stephen Harrap, Rhian M Touyz, Jeong Bae Park

Journal article | 2013 | Journal of Hypertension

Intensive glucose control improves kidney outcomes in patients with type 2 diabetes.

Vlado Perkovic, Hiddo Lambers Heerspink, John Chalmers, Mark Woodward, Min Jun, Qiang Li, Stephen MacMahon, Mark E Cooper, Pavel Hamet, Michel Marre, Carl Erik Mogensen, Neil Poulter, Giuseppe Mancia, Alan Cass, Anushka Patel, Sophia Zoungas, undefined ADVANCE Collaborative Group

Journal article | 2013 | Kidney International

The effect of intensive glucose control on major kidney outcomes in type 2 diabetes remains unclear. To study this, the ADVANCE tr..

Latin American consensus on hypertension in patients with diabetes type 2 and metabolic syndrome

Patricio Lopez-Jaramillo, Ramiro A Sanchez, Margarita Diaz, Leonardo Cobos, Alfonso Bryce, Jose Z Parra Carrillo, Fernando Lizcano, Fernando Lanas, Isaac Sinay, Ivan D Sierra, Ernesto Penaherrera, Mario Bendersky, Helena Schmid, Rodrigo Botero, Manuel Urina, Joffre Lara, Milton C Foss, Gustavo Marquez, Stephen Harrap, Agustin J Ramirez, et al.

Journal article | 2013 | Journal of Hypertension

Blood Pressure Reduction And Stroke Recurrence: The Progress Trial

Hisatomi Arima, Craig Anderson, Teruo Omae, Mark Woodward, Stephen MacMahon, Giuseppe Mancia, Marie-Germaine Bousser, Christophe Tzourio, Stephen Harrap, Bruce Neal, John Chalmers

Conference Proceedings | 2013 | STROKE

The ACE2 gene: its potential as a functional candidate for cardiovascular disease

Louise M Burrell, Stephen B Harrap, Elena Velkoska, Sheila K Patel

Journal article | 2013 | Clinical Science

Blood pressure reduction and stroke recurrence: the PROGRESS trial

H Arima, C Anderson, T Omae, M Woodward, S MacMahon, G Mancia, M-G Bousser, C Tzourio, S Harrap, B Neal, J Chalmers

Conference Proceedings | 2013 | CEREBROVASCULAR DISEASES

Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

G-D Batty, Q Li, R Huxley, S Zoungas, B-A Taylor, B Neal, B de Galan, M Woodward, S-B Harrap, S Colagiuri, A Patel, J Chalmers

Journal article | 2013 | European Psychiatry

The Influence of Exercise on Vascular Complications and Mortality Ii Patients with Type 2 Diabetes Mellitus

Juuso I Maekinen, Clara Chow, Sophia Zoungas, Stephen Harrap, Michel Marre, Bruce Neal, Neil Poulter, Anushka Patel, Mark Woodward, John Chalmers, Graham Hillis

Conference Proceedings | 2012 | CIRCULATION

The 2012 John Swales lecture: Questions unanswered-30 years in the world of blood pressure

Stephen B Harrap

Journal article | 2012 | Journal of Hypertension

Up-regulation of autophagic pathways early in life might contribute to cardiac hypertrophy in a heritable polygenic model

F Marques, S Quarrell, V Jayaswal, C Curl, S Nankervis, JYH Yang, L Delbridge, S Harrap, FJ Charchar

Journal article | 2012 | JOURNAL OF HUMAN HYPERTENSION

Effects of blood pressure lowering on cardiovascular outcomes in different cardiovascular risk groups among participants with type 2 diabetes

Susan van Dieren, Andre P Kengne, John Chalmers, Joline WJ Beulens, Mark E Cooper, Diederick E Grobbee, Stephen Harrap, Giuseppe Mancia, Bruce Neal, Anushka Patel, Neil Poulter, Yvonne T van der Schouw, Mark Woodward, Sophia Zoungas

Journal article | 2012 | Diabetes Research and Clinical Practice

POST-ISCHEMIC CONTRACTILE RECOVERY OF HYPERTROPHIED FEMALE CARDIOMYOCYTES IS DETERMINED BY MECHANISMS INDEPENDENT OF CA(2 )-TRANSIENT RESTORATION

JR Bell, TW Harding, CL Curl, SB Harrap, LMD Delbridge

Conference Proceedings | 2012 | HYPERTENSION

RELATIONSHIP BETWEEN ABERRANT CARDIAC MICRORNA EXPRESSION IN HERITABLE POLYGENIC CARDIAC HYPERTROPHY

F Charchar, S Quarrell, C Curl, S Nankervis, E Molina, L Delbridge, S Harrap

Conference Proceedings | 2012 | HYPERTENSION

INITIAL ORTHOSTATIC HYPOTENSION-THE IMPORTANCE OF A RISE OR FALL IN CARDIAC OUTPUT?

S Harrap, J Bourke, J Ziogas, M Hargreaves

Conference Proceedings | 2012 | HYPERTENSION

REAL-TIME BLOOD PRESSURE MONITORING DURING HAEMODIALYSIS IDENTIFIES UNRECOGNISED HAEMODYNAMIC INSTABILITY, ESPECIALLY IN DIABETIC SUBJECTS

S Wilson, G Becker, S Harrap

Conference Proceedings | 2012 | HYPERTENSION

Association analysis of oestrogen receptor beta gene (ESR2) polymorphisms with female pattern hair loss

L Yip, S Zaloumis, D Irwin, G Severi, J Hopper, G Giles, S Harrap, R Sinclair, J Ellis

Journal article | 2012 | British Journal of Dermatology

The requirement for bioscience knowledge in medical education

Geoffrey J McColl, Justin Bilszta, Stephen Harrap

Journal article | 2012 | Medical Journal of Australia

Cardiac function at term in human pregnancy

Dominica Zentner, Moira du Plessis, Shaun Brennecke, James Wong, Leeanne Grigg, Stephen Harrap

Journal article | 2012 | Pregnancy Hypertension: an international journal of women's cardiovascular health

Common genes with more Type 2 Diabetes complications

J Tremblay, M Haloui, C Long, O Seda, J Chalmers, S Harrap, S MacMahon, M Marre, M Woodward, P Hamet

Journal article | 2012 | Diabetes & Metabolism

Report of the first International Society of Hypertension (ISH) Trainee/New Investigator Symposium: A Global Hypertension Initiative

Dylan Burger, Praveen Veerabhadrappa, Fadi Charchar, Maciej Tomaszewski, Stephen Harrap, Bo Carlberg, Rhian M Touyz

Journal article | 2012 | Journal of Hypertension

Association of HbA(1c) levels with vascular complications and death in patients with type 2 diabetes: evidence of glycaemic thresholds

S Zoungas, J Chalmers, T Ninomiya, Q Li, ME Cooper, S Colagiuri, G Fulcher, BE de Galan, S Harrap, P Hamet, S Heller, S MacMahon, M Marre, N Poulter, F Travert, A Patel, B Neal, M Woodward

Journal article | 2012 | Diabetologia

Council for High Blood Pressure Research/InterAmerican Society of Hypertension/International Society of Hypertension: First New Investigators Symposium at the High Blood Pressure Research 2011 Scientific Sessions

Praveen Veerabhadrappa, Dylan Burger, Fadi Charchar, Maciej Tomaszewski, Bo Carlberg, Stephen Harrap, Rhian M Touyz

Journal article | 2012 | Hypertension

Genomewide Association Study Using a High-Density Single Nucleotide Polymorphism Array and Case-Control Design Identifies a Novel Essential Hypertension Susceptibility Locus in the Promoter Region of Endothelial NO Synthase

Erika Salvi, Zoltan Kutalik, Nicola Glorioso, Paola Benaglio, Francesca Frau, Tatiana Kuznetsova, Hisatomi Arima, Clive Hoggart, Jean Tichet, Yury P Nikitin, Costanza Conti, Jitka Seidlerova, Valerie Tikhonoff, Katarzyna Stolarz-Skrzypek, Toby Johnson, Nabila Devos, Laura Zagato, Simonetta Guarrera, Roberta Zaninello, Andrea Calabria, et al.

Journal article | 2012 | Hypertension

Landscape of combination therapy-which way forward? Proceedings of the satellite symposium held at the ESH European meeting on hypertension and cardiovascular protection, 27 April 2012, London

P Fonseca, AF Dominiczak, S Harrap

Journal article | 2012 | European Cardiology

Early combination therapy is more effective for hypertension control in high-risk patients than monotherapy, and current guideline..

The requirement for bioscience knowledge in medical education

GJ Mccoll, JL Bilszta, SB Harrap

Journal article | 2012 | Medical Journal of Australia

The Epithelial Sodium Channel gamma-Subunit Gene and Blood Pressure Family Based Association, Renal Gene Expression, and Physiological Analyses

Cara J Buesst, Lisa DS Bloomer, Katrina J Scurrah, Justine A Ellis, Timothy A Barnes, Fadi J Charchar, Peter Braund, Paul N Hopkins, Nilesh J Samani, Steven C Hunt, Maciej Tomaszewski, Stephen B Harrap

Journal article | 2011 | Hypertension

A Loss-of-Function Polymorphism in the Human P2X4 Receptor Is Associated With Increased Pulse Pressure

Leanne Stokes, Katrina Scurrah, Justine A Ellis, Brett A Cromer, Kristen K Skarratt, Ben J Gu, Stephen B Harrap, James S Wiley

Journal article | 2011 | Hypertension

Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness

FF Brockschmidt, S Heilmann, JA Ellis, S Eigelshoven, S Hanneken, C Herold, S Moebus, MA Alblas, B Lippke, N Kluck, L Priebe, FA Degenhardt, RA Jamra, C Meesters, K-H Joeckel, R Erbel, S Harrap, J Schumacher, H Froehlich, R Kruse, et al.

Journal article | 2011 | British Journal of Dermatology

Accuracy of national mortality codes in identifying adjudicated cardiovascular deaths

Linton R Harriss, Andrew E Ajani, David Hunt, James Shaw, Brian Chambers, Helen Dewey, Judith Frayne, Alison Beauchamp, Karen Duve, Graham G Giles, Stephen Harrap, Dianna J Magliano, Danny Liew, John McNeil, Anna Peeters, Margaret Stebbing, Rory Wolfe, Andrew Tonkin

Journal article | 2011 | Australian and New Zealand Journal of Public Health

CHARACTERIZATION AND CONSISTENCY OF THE INTRADIALYTIC BLOOD PRESSURE RESPONSE TO MAINTENANCE HAEMODIALYSIS (HD) BY CONTINUOUS RECORDING

S Wilson, G Becker, S Harrap

Journal article | 2011 | NEPHROLOGY

UNMEASURED AND UNKNOWN; DO ROUTINE CLINICAL OBSERVATIONS MISS THE TRUE NATURE OF INTRADIALYTIC BLOOD PRESSURE EVENTS?

S Wilson, G Becker, S Harrap

Journal article | 2011 | NEPHROLOGY

ISH Hypertension Future Leaders Group: a network for new investigators run by new investigators

Praveen Veerabhadrappa, Dylan Burger, Bo Carlberg, Fadi Charchar, Maciej Tomaszewski, Stephen Harrap

Journal article | 2011 | Journal of Hypertension

Effects of perindopril-indapamide on left ventricular diastolic function and mass in patients with type 2 diabetes: the ADVANCE Echocardiography Substudy

Robert N Doughty, GA Whalley, GD Gamble, J Baker, J Chalmers, M Cooper, K Cruickshank, P Dixon, P Dunne, D Eccleston, G Jerums, R Luke, B McGrath, C Nolan, A Patel, N Poulter, P Phillips, R Scott, J Singh, R Smith, et al.

Journal article | 2011 | Journal of Hypertension

Evidence of increased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia

JE Cobb, NC Wong, LW Yip, J Martinick, R Bosnich, RD Sinclair, JM Craig, R Saffery, SB Harrap, JA Ellis

Journal article | 2011 | British Journal of Dermatology

INCREASED SYSTEMIC VASCULAR RESISTANCE IS ASSOCIATED WITH THE DECLINE IN CARDIAC FUNCTION IN NORMAL PREGNANCY NEAR TERM

D Zentner, M du Plessis, S Brennecke, J Wong, L Grigg, S Harrap

Conference Proceedings | 2011 | HYPERTENSION

GENOME-WIDE ASSOCIATION STUDY OF RETINAL ARTERIOLAR DIMENSIONS AND INTERACTION WITH CORONARY RISK FACTORS

JJ Wang, J Xie, M Inouye, G Liew, P Mitchell, PN Baird, T Wong, S Harrap

Conference Proceedings | 2011 | HYPERTENSION

Differential response to resistance training in CHF according to ACE genotype

Andrew D Williams, Mitchell J Anderson, Steve Selig, Michael F Carey, Mark A Febbraio, Alan Hayes, Deidre Toia, Stephen B Harrap, David L Hare

Journal article | 2011 | International Journal of Cardiology

Contemporary model for cardiovascular risk prediction in people with type 2 diabetes.

Andre Pascal Kengne, Anushka Patel, Michel Marre, Florence Travert, Michel Lievre, Sophia Zoungas, John Chalmers, Stephen Colagiuri, Diederick E Grobbee, Pavel Hamet, Simon Heller, Bruce Neal, Mark Woodward, undefined ADVANCE Collaborative Group

Journal article | 2011 | European Journal of Cardiovascular Prevention & Rehabilitation

BACKGROUND: Existing cardiovascular risk prediction equations perform non-optimally in different populations with diabetes. Thus, ..

A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals

Jasper J Brugts, Aaron Isaacs, Moniek PM de Maat, Eric Boersma, Cock M van Duijn, K Martijn Akkerhuis, Andre G Uitterlinden, Jacqueline CM Witteman, Francois Cambien, Claudio Ceconi, Willem Remme, Michel Bertrand, Toshiharu Ninomiya, Stephen Harrap, John Chalmers, Stephen MacMahon, Kim Fox, Roberto Ferrari, Maarten L Simoons, AH Jan Danser

Journal article | 2011 | Journal of Hypertension

Genetics of hypertension and cardiovascular disease.

Tomohiro Katsuya, Stephen B Harrap, Toshio Ogihara

Journal article | 2011 | International Journal of Hypertension

Issues in the development of new combinations of blood pressure lowering drugs

John Chalmers, Stephen Harrap, Krzysztof Narkiewicz, Neil Poulter, Josep Redon, Alberto Zanchetti, Giuseppe Mancia

Journal article | 2010 | Journal of Hypertension

Erectile Dysfunction and Later Cardiovascular Disease in Men With Type 2 Diabetes

G David Batty, Qiang Li, Sebastien Czernichow, Bruce Neal, Sophia Zoungas, Rachel Huxley, Anushka Patel, Bastiaan E de Galan, Mark Woodward, Pavel Hamet, Stephen B Harrap, Neil Poulter, John Chalmers

Journal article | 2010 | Journal of the American College of Cardiology

Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene

Joanna E Cobb, Sophie G Zaloumis, Katrina J Scurrah, Stephen B Harrap, Justine A Ellis

Journal article | 2010 | Experimental Dermatology

Association between alcohol consumption and diabetic retinopathy and visual acuity-the AdRem Study

CC Lee, RP Stolk, AI Adler, A Patel, J Chalmers, B Neal, N Poulter, S Harrap, M Woodward, M Marre, DE Grobbee, JW Beulens

Journal article | 2010 | Diabetic Medicine

The efficacy of lowering glycated haemoglobin with a gliclazide modified release-based intensive glucose lowering regimen in the ADVANCE trial

S Zoungas, J Chalmers, AP Kengne, A Pillai, L Billot, B de Galan, M Marre, B Neal, S Harrap, N Poulter, A Patel

Journal article | 2010 | Diabetes Research and Clinical Practice

Association between estrogen receptor beta gene (ESR2) polymorphisms and female pattern hair loss - more evidence for a detrimental role for estrogens in hair growth

L Yip, S Zaloumis, D Irwin, G Severi, R Sinclair, S Harrap, J Ellis

Conference Proceedings | 2010 | EXPERIMENTAL DERMATOLOGY

Inequalities in cardiovascular disease mortality: the role of behavioural, physiological and social risk factors

Alison Beauchamp, Anna Peeters, Rory Wolfe, Gavin Turrell, Linton R Harriss, Graham G Giles, Dallas R English, John McNeil, Dianna Magliano, Stephen Harrap, Danny Liew, David Hunt, Andrew Tonkin

Journal article | 2010 | Journal of Epidemiology & Community Health

Efficacy and safety of routine blood pressure lowering in older patients with diabetes: results from the ADVANCE trial

Toshiharu Ninomiya, Sophia Zoungas, Bruce Neal, Mark Woodward, Anushka Patel, Vlado Perkovic, Alan Cass, Mark Cooper, Diederick Grobbee, Pavel Hamet, Stephen Harrap, Lisheng Liu, Giuseppe Mancia, Carl-Erik Mogensen, Neil Poulter, Anthony Rodgers, Bryan Williams, Stephen MacMahon, John Chalmers

Journal article | 2010 | Journal of Hypertension

The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) Study.

AP Kengne, A Patel, S Colagiuri, S Heller, P Hamet, M Marre, CY Pan, S Zoungas, DE Grobbee, B Neal, J Chalmers, M Woodward, undefined ADVANCE Collaborative Group

Journal article | 2010 | Diabetologia

AIMS/HYPOTHESIS: Available multivariable equations for cardiovascular risk assessment in people with diabetes have been derived ei..

International Society of Hypertension Low and Middle Income Countries Committee Review of the Goals of the Committee and of 5 years of ISH activities in Low and Middle Income Countries

RH Fagard, G Grassi, J Hall, S Harrap, LH Lindholm, EL Schiffrin, AM Heagerty

Conference Proceedings | 2010 | Journal of Hypertension

Genes controlling postural changes in blood pressure: comprehensive association analysis of ATP-sensitive potassium channel genes KCNJ8 and ABCC9

Justine A Ellis, Angela Lamantia, Raul Chavez, Katrina J Scurrah, Colin G Nichols, Stephen B Harrap

Journal article | 2010 | Physiological Genomics

Event Rates, Hospital Utilization, and Costs Associated with Major Complications of Diabetes: A Multicountry Comparative Analysis

Philip M Clarke, Paul Glasziou, Anushka Patel, John Chalmers, Mark Woodward, Stephen B Harrap, Joshua A Salomon

Journal article | 2010 | PLoS Medicine

Baldness and the androgen receptor - where are we and where are we going?

J Ellis, J Cobb, L Yip, S Harrap

Conference Proceedings | 2009 | JOURNAL OF INVESTIGATIVE DERMATOLOGY

Analysis of aromatase gene (CYP19A1) polymorphisms in female pattern hair loss

L Yip, D Irwin, R Sinclair, S Harrap, J Ellis

Conference Proceedings | 2009 | JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hair follicle methylation of the androgen receptor gene in male pattern baldness

J Cobb, L Yip, N Wong, S Harrap, J Ellis

Conference Proceedings | 2009 | JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial

BE de Galan, S Zoungas, J Chalmers, C Anderson, C Dufouil, A Pillai, M Cooper, DE Grobbee, M Hackett, P Hamet, SR Heller, L Lisheng, S MacMahon, G Mancia, B Neal, CY Pan, A Patel, N Poulter, F Travert, M Woodward

Journal article | 2009 | Diabetologia

Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial.

Sophia Zoungas, Bastiaan E de Galan, Toshiharu Ninomiya, Diederick Grobbee, Pavel Hamet, Simon Heller, Stephen MacMahon, Michel Marre, Bruce Neal, Anushka Patel, Mark Woodward, John Chalmers, undefined ADVANCE Collaborative Group, Alan Cass, Paul Glasziou, Stephen Harrap, Liu Lisheng, Guiseppe Mancia, Avinesh Pillai, Neil Poulter, et al.

Journal article | 2009 | Diabetes Care

OBJECTIVE: To assess the magnitude and independence of the effects of routine blood pressure lowering and intensive glucose contro..

Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss

L Yip, S Zaloumis, D Irwin, G Severi, J Hopper, G Giles, S Harrap, R Sinclair, J Ellis

Journal article | 2009 | British Journal of Dermatology

Blood Pressure Variables and Cardiovascular Risk New Findings From ADVANCE

Andre-Pascal Kengne, Sebastien Czernichow, Rachel Huxley, Diederick Grobbee, Mark Woodward, Bruce Neal, Sophia Zoungas, Mark Cooper, Paul Glasziou, Pavel Hamet, Stephen B Harrap, Giuseppe Mancia, Neil Poulter, Bryan Williams, John Chalmers

Journal article | 2009 | Hypertension

Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes.

Toshiharu Ninomiya, Vlado Perkovic, Bastiaan E de Galan, Sophia Zoungas, Avinesh Pillai, Meg Jardine, Anushka Patel, Alan Cass, Bruce Neal, Neil Poulter, Carl-Erik Mogensen, Mark Cooper, Michel Marre, Bryan Williams, Pavel Hamet, Giuseppe Mancia, Mark Woodward, Stephen Macmahon, John Chalmers, undefined ADVANCE Collaborative Group

Journal article | 2009 | Journal of the American Society of Nephrology

There are limited data regarding whether albuminuria and reduced estimated GFR (eGFR) are separate and independent risk factors fo..

Blood pressure genetics: time to focus

Stephen B Harrap

Journal article | 2009 | Journal of the American Society of Hypertension

THE FIXED COMBINATION OF PERINDOPRIL AND INDAPAMIDE HAS A GREATER EFFECT ON CARDIOVASCULAR OUTCOMES IN PATIENTS WITH TYPE 2 DIABETES AND ALBUMINURIA

T Ninomiya, S Zoungas, B de Galan, A Patel, V Perkovic, D Grobbee, S Harrap, S Heller, M Cooper, S Macmahon, G Mancia, M Marre, B Neal, M Woodward, J Chalmers

Conference Proceedings | 2009 | JOURNAL OF HYPERTENSION

THE EFFECTS OF A FIXED COMBINATION OF PERINDOPRIL AND INDAPAMIDE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ACCORDING TO BASELINE CARDIOVASCULAR RISK IN THE ADVANCE TRIAL

S Zoungas, T Ninomiya, A Patel, V Perkovic, M Woodward, D Grobbee, S Harrap, S Macmahon, G Mancia, M Marre, C Mogensen, B Neal, N Poulter, B Williams, J Chalmers

Conference Proceedings | 2009 | JOURNAL OF HYPERTENSION

COMPREHENSIVE ANALYSIS OF THE ROLE OF ATP-SENSITIVE POTASSIUM CHANNEL GENES, ABCC9 AND KCNJ8, IN DETERMINING POSTURAL CHANGES IN BLOOD PRESSURE

JA Ellis, A Lamantia, KJ Scurrah, C Nichols, SB Harrap

Conference Proceedings | 2009 | HYPERTENSION

AUGMENTED MYOCARDIAL PI3-K MEDIATED SIGNALLING IN THE NEONATE PRECEEDS ADULT PATHOLOGICAL HYPERTROPHY IN THE HYPERTROPHIC HEART RAT (HHR)

JR Bell, ER Porrello, SB Harrap, LMD Delbridge

Conference Proceedings | 2009 | HYPERTENSION

BLOOD PRESSURE AND THE beta-SUBUNIT OF THE EPITHELIAL SODIUM CHANNEL

C Buesst, K Scurrah, A Lamantia, J Ellis, S Harrap

Conference Proceedings | 2009 | HYPERTENSION

Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor-Mediated Cardiomyocyte Autophagy

Enzo R Porrello, Angelo D'Amore, Claire L Curl, Andrew M Allen, Stephen B Harrap, Walter G Thomas, Lea MD Delbridge

Journal article | 2009 | Hypertension

Risks of cardiovascular events and effects of routine blood pressure lowering among patients with type 2 diabetes and atrial fibrillation: results of the ADVANCE study

Xin Du, Toshiharu Ninomiya, Bastiaan de Galan, Edward Abadir, John Chalmers, Avinesh Pillai, Mark Woodward, Mark Cooper, Stephen Harrap, Pavel Hamet, Neil Poulter, Gregory YH Lip, Anushka Patel

Journal article | 2009 | European Heart Journal

Androgen Receptor Copy Number Variation and Androgenetic Alopecia: A Case-Control Study

Joanna E Cobb, Stefan J White, Stephen B Harrap, Justine A Ellis

Journal article | 2009 | PLoS ONE

Deterioration in cardiac systolic and diastolic function late in normal human pregnancy

Dominica Zentner, Moira du Plessis, Shaun Brennecke, James Wong, Leeanne Grigg, Stephen B Harrap

Journal article | 2009 | Clinical Science

New perspectives in the treatment of the diabetic patient. ADVANCE Study

S Harrap, A Patel, J Chalmers

Journal article | 2009 | Hipertensión y Riesgo Vascular

Lowering Blood Pressure Reduces Renal Events in Type 2 Diabetes

Bastiaan E de Galan, Vlado Perkovic, Toshiharu Ninomiya, Avinesh Pillai, Anushka Patel, Alan Cass, Bruce Neal, Neil Poulter, Stephen Harrap, Carl-Erik Mogensen, Mark Cooper, Michel Marre, Bryan Williams, Pavel Hamet, Giuseppe Mancia, Mark Woodward, Paul Glasziou, Diederick E Grobbee, Stephen MacMahon, John Chalmers

Journal article | 2009 | Journal of the American Society of Nephrology

Heritable pathologic cardiac hypertrophy in adulthood is preceded by neonatal cardiac growth restriction

Enzo R Porrello, James R Bell, Jonathan D Schertzer, Claire L Curl, Julie R McMullen, Kimberley M Mellor, Rebecca H Ritchie, Gordon S Lynch, Stephen B Harrap, Walter G Thomas, Lea MD Delbridge

Journal article | 2009 | American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Contribution of genes and environment to variation in postural changes in mean arterial and pulse pressure

Katrina J Scurrah, Sophie G Zaloumis, John L Hopper, Stephen B Harrap

Journal article | 2008 | Journal of Hypertension

SUPPRESSION OF MYOCARDIAL APOPTOSIS IN NEONATAL RATS IS A PRELUDE TO PRIMARY CARDIAC HYPERTROPHY IN ADULTHOOD

ER Porrello, JD Schertzer, CL Curl, WF Meeker, GS Lynch, SB Harrap, WG Thomas, LMD Delbridge

Conference Proceedings | 2008 | HYPERTENSION

BLOOD PRESSURE LOWERING WITH FIXED COMBINATION OF PERINDOPRIL AND INDAPAMIDE PREVENTS DEATH AND VASCULAR EVENTS IN TYPE 2 DIABETES: THE ADVANCE TRIAL

J Chalmers, A Patel, S MacMahon, B Neal, SB Harrap, M Cooper

Conference Proceedings | 2008 | HYPERTENSION

CONTRIBUTION OF GENES AND ENVIRONMENT TO POSTURAL CHANGES IN BLOOD PRESSURE

SG Zaloumis, KJ Scurrah, SB Harrap

Conference Proceedings | 2008 | HYPERTENSION

Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes

Anushka Patel, Stephen MacMahon, John Chalmers, Bruce Neal, Laurent Billot, Mark Woodward, Michel Marre, Mark Cooper, Paul Glasziou, Diederick Grobbee, Pavel Hamet, Stephen Harrap, Simon Heller, Lisheng Liu, Giuseppe Mancia, Carl Erik Mogensen, Changyu Pan, Neil Poulter, Anthony Rodgers, Bryan Williams, et al.

Journal article | 2008 | New England Journal of Medicine

Lack of association between a common coronary heart disease allele and blood pressure

SB Harrap, K Scurrah, A Lamantia, J Ellis

Conference Proceedings | 2008 | JOURNAL OF HYPERTENSION

Renoprotection with perindopril-indapamide below current recommended blood pressure targets in patients with type 2 diabetes mellitus: Results of the ADVANCE trial

BE de Galan, J Chalmers, V Perkovic, T Ninomiya, A Pillai, A Patel, A Cass, S Macmahon, B Neal, C-E Mogensen, M Marre, SB Harrap, NR Poulter, ME Cooper, G Mancia

Conference Proceedings | 2008 | JOURNAL OF HYPERTENSION

Confirmation of association of the epithelial sodium channel with blood pressure in the victorian family heart study

CJ Busst, K Scurrah, J Ellis, S Harrap

Conference Proceedings | 2008 | JOURNAL OF HYPERTENSION

Myocardial gene expression associated with genetic cardiac hypertrophy in the absence of hypertension

Jeremy P Dwyer, Matthew E Ritchie, Gordon K Smyth, Stephen B Harrap, Lea MD Delbridge, Andrea A Domenighetti, Robert Di Nicolantonio

Journal article | 2008 | Hypertension Research

APOE genotype, ethnicity, and the risk of cerebral hemorrhage

C Tzourio, H Arima, S Harrap, C Anderson, O Godin, M Woodward, B Neal, M-G Bousser, J Chalmers, F Cambien, S MacMahon

Journal article | 2008 | Neurology

The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy

James R Bell, Enzo R Porrello, Catherine E Huggins, Stephen B Harrap, Lea MD Delbridge

Journal article | 2008 | American Journal of Physiology - Heart and Circulatory Physiology

Searching for functional genetic variants in non-coding DNA

Joanna Cobb, Cara Busst, Steven Petrou, Stephen Harrap, Justine Ellis

Journal article | 2008 | Clinical and Experimental Pharmacology and Physiology

Analysis of the estrogen receptor beta gene, ESR2, in female pattern hair loss

L Yip, S Harrap, R Sinclair, J Ellis

Conference Proceedings | 2007 | JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epithelial sodium channel gamma-subunit polymorphisms are associated with 25-year follow-up blood pressures in Utah pedigrees

Cara J Busst, Katrina J Scurrah, Justine A Ellis, Yuanpei Xin, Eliot A Brinton, Paul N Hopkins, Stephen B Harrap, Steven C Hunt

Conference Proceedings | 2007 | HYPERTENSION

Selective genotyping reveals association between the epithelial sodium channel gamma-subunit and systolic blood pressure

Cara J Busst, Katrina J Scurrah, Justine A Ellis, Stephen B Harrap

Journal article | 2007 | Hypertension

Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial

A Patel, S MacMahon, J Chalmers, B Neal, M Woodward, L Billot, S Harrap, N Poulter, M Marre, M Cooper, P Glasziou, DE Grobbee, P Hamet, S Heller, LS Liu, G Mancia, CE Mogensen, CY Pan, A Rodgers, B Williams

Journal article | 2007 | The Lancet

Sex-dependence of environmental influences on blood pressure

SG Zaloumis, KJ Scurrah, SB Harrap

Conference Proceedings | 2007 | HYPERTENSION

Cardiovascular genetics - Two steps forward, one step back

Stephen B Harrap

Journal article | 2007 | Annals of the Academy of Medicine Singapore

Longitudinal analysis of left ventricular function in overweight pregnancy

D Zentner, M du Plessis, S Brennecke, J Wong, L Grigg, S Harrap

Conference Proceedings | 2007 | HYPERTENSION

Association of the PIK3CA gene with cardiac structure and function in human hypertension

A Muthusamy, R Di Nicolantonio, J Ellis, K Scurrah, SG Zaloumis, S Harrap, G Jennings, C Reid, Lindon Wing

Conference Proceedings | 2007 | HYPERTENSION

Longitudinal analysis of cardiovascular characteristics in pregnancy

D Zentner, M du Plessis, S Brennecke, J Wong, L Grigg, S Harrap

Conference Proceedings | 2007 | HYPERTENSION

SCNN1G variants are associated with systolic blood pressure in the Victorian Family Heart Study

CJ Busst, KJ Scurrah, JA Ellis, SB Harrap

Conference Proceedings | 2007 | HYPERTENSION

Allelic variants of the angiotensin type 1 receptor gene and human heart size

I Chiu, R Di Nicolantonio, JA Ellis, JE Cobb, KJ Scurrah, SG Zaloumis, SB Harrap, GLR Jennings, CM Reid, L Wing

Conference Proceedings | 2007 | HYPERTENSION

Elevated levels of phosphorylated Akt in hypertrophy pre-destined neonatal hearts

Enzo R Porrello, Jonathan D Schertzer, Claire L Curl, Gordon S Lynch, Stephen B Harrap, Walter G Thomas, Lea MD Delbridge

Conference Proceedings | 2007 | Journal of Molecular and Cellular Cardiology

Baldness and the androgen receptor: the AR polyglycine repeat polymorphism does not confer susceptibility to androgenetic alopecia

Justine A Ellis, Katrina J Scurrah, Joanna E Cobb, Sophie G Zaloumis, Anna E Duncan, Stephen B Harrap

Journal article | 2007 | Human Genetics

Which health-related quality of life score ? A comparison of alternative utility measures in patients with Type 2 diabetes in the ADVANCE trial

Paul Glasziou, Jan Alexander, Elaine Beller, Philip Clarke

Journal article | 2007 | Health and Quality of Life Outcomes

Comprehensive multi-stage linkage analyses identify a locus for adult height on chromosome 3p in a healthy Caucasian population

Justine A Ellis, Katrina J Scurrah, Anna E Duncan, Angela Lamantia, Graham B Byrnes, Stephen B Harrap

Journal article | 2007 | Human Genetics

The genetics of blood pressure in humans a difficult business

SB Harrap, KJ Scurrah, JA Ellis

Conference Proceedings | 2006 | JOURNAL OF HYPERTENSION

Association of SCNN1G variants with systolic blood pressure in the victorian family heart study

Cara J Busst, Katrina J Scurrah, Justine A Ellis, Stephen B Harrap

Conference Proceedings | 2006 | JOURNAL OF HYPERTENSION

Post-natal cardiac development in an experimental model of normotensive cardiac hypertrophy

ER Porrello, CL Curl, SB Harrap, WG Thomas, LMD Delbridge

Conference Proceedings | 2006 | Journal of Molecular and Cellular Cardiology

Angiotensin II receptor imbalance associated with neonatal cardiac growth restriction is a prelude to adult cardiac hypertrophy

Enzo R Porrello, Angelo D'Amore, Claire L Curl, Catherine E Huggins, Stephen B Harrap, Walter G Thomas, Lea M Delbridge

Conference Proceedings | 2006 | CIRCULATION RESEARCH

Sex differences in genetic and environmental determinants of pulse pressure

KJ Scurrah, GB Byrnes, JL Hopper, SB Harrap

Journal article | 2006 | Genetic Epidemiology

Genome-wide linkage analysis of population variation in high-density lipoprotein cholesterol

SB Harrap, ZYH Wong, KJ Scurrah, A Lamantia

Journal article | 2006 | Human Genetics

Fine mapping of Lvm1: a quantitative trait locus controlling heart size independently of blood pressure

R Di Nicolantonio, V Kostka, A Kwitek, H Jacob, WG Thomas, SB Harrap

Journal article | 2006 | Pulmonary Pharmacology and Therapeutics

Blood Pressure Genetics

SB Harrap

Book Chapter | 2005

Variance components models for ordinal family data: Baldness and the androgen receptor gene

KJ Scurrah, JA Ellis, JE Cobb, JL Hopper, SB Harrap

Conference Proceedings | 2005 | GENETIC EPIDEMIOLOGY

Androgenic correlates of genetic variation in the gene encoding 5 alpha-reductase type 1

JA Ellis, S Panagiotopoulos, A Akdeniz, G Jerums, SB Harrap

Journal article | 2005 | Journal of Human Genetics

Enhanced inotropic responses of cardiomyocytes from the hypertrophic heart rat: A model of normotensive cardiac hypertrophy

CL Curl, AM Caldwell, SB Harrap, LMD Delbridge

Conference Proceedings | 2005 | JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Evidence suggestive of an angiotensin II-dependent cardiomyocyte cull in neonatal hypertrophic heart rat

ER Porrello, A D'Amore, CE Huggins, CL Curll, SB Harrap, WG Thomas, LMD Delbridge

Conference Proceedings | 2005 | JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Differentially expressed genes in cardiac tissue from the hypertrophic heart rat

JP Dwyer, ME Ritchie, GK Smyth, LM Delbridge, AA Domenighetti, SB Harrap, R Di Nicolantonio

Conference Proceedings | 2005 | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Androgen receptor CAG repeat polymorphism and bone density: A family and case-control association study in men with primary osteoporosis.

PR Ebeling, Z Hussein, J Ellis, A Lamantia, K Greenland, S Yeung, ZYH Wong, JD Zajac, S Harrap

Conference Proceedings | 2004 | JOURNAL OF BONE AND MINERAL RESEARCH

Genetic analysis of the androgen receptor gene in female pattern hair loss

S Harrison, JA Ellis, R Sinclair, SB Harrap

Conference Proceedings | 2004 | BRITISH JOURNAL OF DERMATOLOGY

Sex-dependent association of blood pressure with oestrogen receptor genes ER alpha and ER beta

JA Ellis, T Infantino, SB Harrap

Journal article | 2004 | Journal of Hypertension

Does the angiotensin II type 1(B) receptor gene explain the lvm-1 cardiac hypertrophy locus?

V Kostka, MZ Chow, P Jansa, SB Harrap, R Di Nicolantonio

Conference Proceedings | 2004 | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Genome-wide linkage analysis of pulse pressure: The Victorian Family Heart Study

ZYW Wong, JS Cui, JL Hopper, SB Harrap

Conference Proceedings | 2004 | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Renal function in the genetically inbred hypertrophic heart rat (HHR)

S Hiranyachattada, PJ Harris, SB Harrap, LMD Delbridge

Conference Proceedings | 2004 | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

No association between the 3 beta-hydroxysteroid dehydrogenase type 1 gene and blood pressure in men and women: The Victorian Family Heart Study

JA Ellis, R Infantino, N Harun, SB Harrap

Conference Proceedings | 2004 | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Sequence analysis of the fibroblast growth factor 2 gene from the spontaneously hypertensive and hypertrophic heart rats

JP Dwyer, V Kostka, SB Harrap, R Di Nicolantonio

Journal article | 2004 | Clinical and Experimental Hypertension

Treatment with the beta(2)-agonist fenoterol attenuates age-related alterations in skeletal muscle sarcoplasmic reticulum Ca2 -ATPase function

JD Schertzer, JG Ryall, DR Plant, SB Harrap, GS Lynch

Conference Proceedings | 2004 | FASEB JOURNAL

Familial and genomic analyses of postural changes in systolic and diastolic blood pressure

SB Harrap, JSS Cui, ZYH Wong, JL Hopper

Journal article | 2004 | Hypertension

Reductions in the risks of recurrent stroke in patients with and without diabetes: The PROGRESS trial

K Berthet, BC Neal, JP Chalmers, SW Macmahon, M Bousser, SA Colman, M Woodward

Journal article | 2004 | Blood Pressure

A genomewide scan for loci contributing to population variation in adult height

JA Ellis, ZYH Wong, SB Harrap

Conference Proceedings | 2003 | AMERICAN JOURNAL OF HUMAN GENETICS

Tall stories: the devilish detail of genetic association studies

JA Ellis, SB Harrap

Journal article | 2003 | Clinical Endocrinology

The ACE gene I/D polymorphism is not associated with the blood pressure and cardiovascular benefits of ACE inhibition

SB Harrap, C Tzourio, F Cambien, O Poirier, S Raoux, J Chalmers, N Chapman, S Colman, S Leguennec, S MacMahon, B Neal, T Ohkubo, M Woodward

Journal article | 2003 | Hypertension

Recent advances in the genetics of human blood pressure

S Harrap

Conference Proceedings | 2003 | Atherosclerosis Supplements

Deletion of the CD36 gene does not necessarily lead to hypertension or cardiac hypertrophy

V Kostka, J Dwyer, R Di Nicolantonio, SB Harrap

Conference Proceedings | 2003 | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

ACE-inhibition selectively reverses genetic cardiomyocyte hypertrophy in HHR

G Davis, A Caldwell, SB Harrap, LM Delbridge

Conference Proceedings | 2003 | CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Where are all the blood-pressure genes?

SB Harrap

Journal article | 2003 | The Lancet

Deletion of the Cd36 gene does not necessarily lead to hypertension and cardiac hypertrophy

V Kostka, J Dwyer, AM Caldwelll, LM Delbridge, R Di Nicolantonio, SB Harrap

Conference Proceedings | 2003 | JOURNAL OF HYPERTENSION

Androgen receptor CAG repeat polymorphism and bone density in men

Z Hussein, J Ellis, A Lamantia, K Greenland, S Yeung, Z Wong, ZD Zajac, SB Harrap, PR Ebeling

Conference Proceedings | 2003 | BONE

Genetic association studies

SB Harrap, JA Ellis

Conference Proceedings | 2003 | EXPERIMENTAL DERMATOLOGY

The androgen receptor: a search for functional androgenetic alopecia variants

A Ellis, SB Harrap

Conference Proceedings | 2003 | EXPERIMENTAL DERMATOLOGY

Female androgenetic alopecia and the androgen receptor gene

S Harrison, R Sinclair, J Ellis, S Harrap

Conference Proceedings | 2003 | EXPERIMENTAL DERMATOLOGY

Antihypertensive treatments obscure familial contributions to blood pressure variation

JSS Cui, JL Hopper, SB Harrap

Journal article | 2003 | Hypertension

Androgenetic alopecia: pathogenesis and potential for therapy.

Justine A Ellis, Rodney Sinclair, Stephen B Harrap

Journal article | 2002 | Expert Reviews in Molecular Medicine

Androgenetic alopecia occurs in men and women, and is characterised by the loss of hair from the scalp in a defined pattern. Deter..

Genetic associations with cardiovascular risk and their dependence on sex.

JA Ellis, SB Harrap

Conference Proceedings | 2002 | AMERICAN JOURNAL OF HUMAN GENETICS

Altered excitation-contraction coupling in the HHR - A new model of normotensive cardiac hypertrophy

VR Danes, AM Caldwell, SB Harrap, LMD Delbridge

Journal article | 2002 | Journal of Molecular and Cellular Cardiology

Genes and family environment explain correlations between blood pressure and body mass index.

Jisheng Cui, John L Hopper, Stephen B Harrap

Journal article | 2002 | Hypertension

The correlations between systolic blood pressure (SBP) and diastolic blood pressure (DBP), and between SBP and body mass index (BM..

Genes and family environment explain correlations between blood pressure and body mass index

JS Cui, JL Hopper, SB Harrap

Journal article | 2002 | Hypertension

Genome-wide linkage analysis of the acute coronary syndrome suggests a locus on chromosome 2

SB Harrap, KS Zammit, ZYH Wong, FM Williams, M Bahlo, AM Tonkin, ST Anderson

Journal article | 2002 | Arteriosclerosis Thrombosis and Vascular Biology

The hypertrophic heart rat: a new normotensive model of genetic cardiac and cardiomyocyte hypertrophy

SB Harrap, VR Danes, JA Ellis, CD Griffiths, EF Jones, LMD Delbridge

Journal article | 2002 | Physiological Genomics

Blood pressure QTLs identified by genome-wide linkage analysis and dependence on associated phenotypes

SB Harrap, ZYH Wong, M Stebbing, A Lamantia, M Bahlo

Journal article | 2002 | Physiological Genomics

Blood pressure QTLs identified by genome-wide linkage analysis and dependence on associated phenotypes.

SB Harrap, ZYH Wong, M Stebbing, A Lamantia, M Bahlo

Journal article | 2002 | Physiological genomics

Sex, genes and blood pressure

JA Ellis, ZY Wong, M Stebbing, SB Harrap

Journal article | 2001 | Clinical and Experimental Pharmacology and Physiology

ACE gene polymorphism is not a predictor of chronic heart failure or aerobic fitness

DL Hare, MJ Anderson, MA Febbraio, SB Harrap, A Williams, MF Carey, S Selig

Journal article | 2001 | CIRCULATION

Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack

S MacMahon, B Neal, C Tzourio, A Rodgers, M Woodward, J Curler, C Anderson, J Chalmers, T Ohkubo, MG Bousser, S Davis, G Donnan, L Hansson, S Harrap, KR Lees, L Liu, G Mancia, T Omae, J Reid, R Sega, et al.

Journal article | 2001 | The Lancet

Study Rationale and Design of ADVANCE: Action in and vascular disease - preterax and diamicron MR evaluation

J Chalmers, M Cooper, E Ferrannini, P Glasziou, D Grobbee, P Hamet, S Harrap, L Liu, S MacMahon, G Mancia, M Marre, D Matthews, C Mogensen, B Neal, CY Pan, N Poulter, A Rodgers, B Williams, M Woodward

Journal article | 2001 | Diabetologia

Mislabelling of Donryu rats

SB Harrap, Y Ohno

Journal article | 2001 | Hypertension

Significant population variation in adult male height associated with the Y chromosome and the aromatase gene

JA Ellis, M Stebbing, SB Harrap

Journal article | 2001 | Journal of Clinical Endocrinology & Metabolism

Utility of genetic approaches to common cardiovascular diseases

SB Harrap, S Petrou

Journal article | 2001 | American Journal of Physiology - Heart and Circulatory Physiology

Physiological relationships between central vascular haemodynamics and left ventricular structure

JA Deague, CM Wilson, LE Grigg, SB Harrap

Journal article | 2001 | Clinical Science

Male pattern baldness is not associated with established cardiovascular risk factors in the general population

JA Ellis, M Stebbing, SB Harrap

Journal article | 2001 | Clinical Science

The genetics of androgenetic alopecia

JA Ellis, SB Harrap

Journal article | 2001 | Clinics in Dermatology

Polymorphism of the androgen receptor gene is associated with male pattern baldness

JA Ellis, M Stebbing, SB Harrap

Journal article | 2001 | Journal of Investigative Dermatology

Genetics of haemostasis

SB Harrap, JL Hopper

Journal article | 2001 | The Lancet

Association of the human Y chromosome with high blood pressure in the general population

JA Ellis, M Stebbing, SB Harrap

Journal article | 2000 | Hypertension

Familial patterns of covariation for cardiovascular risk factors in adults - The Victorian Family Heart Study

SB Harrap, M Stebbing, JL Hopper, HN Hoang, GG Giles

Journal article | 2000 | American Journal of Epidemiology

Honoring Colin Johnston.

SB Harrap

Journal article | 2000 | Hypertension

Increased left ventricular mass is not associated with impaired left ventricular diastolic filling in normal individuals

JA Deague, CM Wilson, LE Grigg, SB Harrap

Journal article | 2000 | Journal of Hypertension

Cardiovascular disease: genes and public health.

SB Harrap

Journal article | 2000 | Annals of the Academy of Medicine Singapore

INTRODUCTION: The advances in molecular biology hold great promise for complex conditions such as cardiovascular disease. Early ac..

New target regions for human hypertension via comparative genomics

M Stoll, AE Kwitek-Black, AW Cowley, EL Harris, SB Harrap, JE Krieger, MP Printz, AP Provoost, J Sassard, HJ Jacob

Journal article | 2000 | Genome Research

Glomerular hyperfiltration, high renin, and low-extracellular volume in high blood pressure

SB Harrap, AD Cumming, DL Davies, CJW Foy, R Fraser, A Kamitani, JM Connor, AF Lever, GCM Watt

Journal article | 2000 | Hypertension

Editorial honoring colin johnston

SB Harrap

Journal article | 2000 | Hypertension

PROGRESS - Perindopril Protection Against Recurrent Stroke Study: characteristics of the study population at baseline

J Chalmers, S MacMahon, MG Bousser, C Tzourio, J Cutler, G Donnan, L Hansson, A Terent, S Harrap, S Davis, L Liu, G Mancia, R Sega, T Omae, J Reid, K Lees, A Rodgers, C Warlow

Journal article | 1999 | Journal of Hypertension

Linkage analysis of endothelial nitric oxide synthase gene with human blood pressure

S Takami, ZYH Wong, M Stebbing, SB Harrap

Journal article | 1999 | Journal of Hypertension

Discrepancies between echocardiographic measurements of left ventricular mass in a healthy adult population

JA Deague, CM Wilson, LE Grigg, SB Harrap

Journal article | 1999 | Clinical Science

Blood pressure measurements in genetic linkage studies

WYS Wang

Journal article | 1999 | The Lancet

Insulin gene polymorphism and premature male pattern baldness in the general population

JA Ellis, M Stebbing, SB Harrap

Journal article | 1999 | Clinical Science

Prevention of genetic hypertension by ace inhibition: Investigation of mechanisms

JB O'Sullivan, SB Harrap, NJ Samani

Journal article | 1999 | Heart

Long-term effects of angiotensin-converting enzyme inhibition on renal medullary neutral lipid in spontaneously hypertensive rats

JB O'Sullivan, SB Harrap

Journal article | 1999 | Hypertension

Mutational analysis of the high affinity immunoglobulin E receptor beta subunit gene in asthma

PW Dickson, ZYH Wong, SB Harrap, MJ Abramson, EH Walters

Journal article | 1999 | Thorax

Genetic linkage of beta and gamma subunits of epithelial sodium channel to systolic blood pressure

ZYH Wong, M Stebbing, JA Ellis, A Lamantia, SB Harrap

Journal article | 1999 | The Lancet

Linkage analysis of glucocorticoid and beta2-adrenergic receptor genes with blood pressure and body mass index.

S Takami, ZY Wong, M Stebbing, SB Harrap

Journal article | 1999 | American Journal of Physiology-Heart and Circulatory Physiology

Glucocorticoids and catecholamines exert important effects on cardiovascular physiology and metabolism. Variants of the glucocorti..

Nerve growth factor gene locus explains elevated renal nerve growth factor mRNA in young spontaneously hypertensive rats

FJ Charchar, MK Kapuscinski, SB Harrap

Journal article | 1998 | Hypertension

Cosegregation of spontaneously hypertensive rat renin gene with elevated blood pressure in an F-2 generation

H Yu, SB Harrap, R Di Nicolantonio

Journal article | 1998 | Journal of Hypertension

Human alpha-adducin gene, blood pressure, and sodium metabolism

A Kamitani, ZYH Wong, R Fraser, DL Davies, JM Connor, CJW Foy, GCM Watt, SB Harrap

Journal article | 1998 | Hypertension

Genetic analysis of male pattern baldness and the 5 alpha-reductase genes

JA Ellis, M Stebbing, SB Harrap

Journal article | 1998 | Journal of Investigative Dermatology

Preventing adult disease: windows of opportunity

SB Harrap

Journal article | 1998 | Clinical Science

Independent genetic susceptibility to cardiac hypertrophy in inherited hypertension

BA Innes, MG McLaughlin, MK Kapuscinski, HJ Jacob, SB Harrap

Journal article | 1998 | Hypertension

Persistent reduction in renal nerve growth factor mRNA after perindopril treatment of young spontaneously hypertensive rats

FJ Charchar, M Kapuscinski, SB Harrap

Journal article | 1998 | Hypertension

The new asthma genetics and its implications for public health.

MJ Abramson, SB Harrap

Journal article | 1998 | Public Health Reviews

OBJECTIVE: To review the genetics of asthma from a public health perspective. DATA SOURCES: Studies of asthma genetics published b..

The comprehensive total genome scan to map genes responsible for high blood pressure in the rat

G Koike, HJ Jacob, AW Cowley, VJ Dzau, D Fanestil, MR Grigor, SB Harrap, EL Harris, EM Krieger, JE Krieger, ES Lander, MP Printz, A Provoost, RJ Roman, NJ Samani, J Sassard, NJ Schork, M Vincent

Journal article | 1997 | FASEB Journal

Strain-specific deletions in exon 10 of rat K-kininogen and T1-kininogen genes allow mapping of both genes to rat Chromosome 11

EL Harris, MR Grigor, BA Innes, SB Harrap, G Koike, HJ Jacob

Journal article | 1997 | Mammalian Genome

Behavioural and cardiovascular responses of rats to euthanasia using carbon dioxide gas

W Smith, SB Harrap

Journal article | 1997 | Laboratory Animals

Absence of genetic linkage of chromosome 5q31 with asthma and atopy in the general population

A Kamitani, ZYH Wong, P Dickson, L vanHerwerden, J Raven, AB Forbes, MJ Abramson, EH Walters, SB Harrap

Journal article | 1997 | Thorax

Linkage analysis of bronchial hyperreactivity and atopy with chromosome 11q13

ZYH Wong, D Tsonis, L vanHerwerden, J Raven, A Forbes, MJ Abramson, EH Walters, SB Harrap

Journal article | 1997 | Electrophoresis

Abnormal epinephrine release in young adults with high personal and high parental blood pressures

SB Harrap, R Fraser, GC Inglis, AF Lever, GH Beastall, MH Dominiczak, CJW Foy, GCM Watt

Journal article | 1997 | Circulation

Cardiovascular hypertrophy does not predispose to genetic hypertension

SB Harrap, EF Jones

Conference Proceedings | 1997 | Clinical and Experimental Hypertension

Private genes, public health

SB Harrap

Journal article | 1997 | The Lancet

PROGRESS - Perindopril protection against recurrent stroke study: Status in July 1996

J Chalmers, S Macmahon, MG Bousser, J Cutler, G Donnan, L Hansson, S Harrap, LS Liu, G Mancia, J Menard, T Omae, J Reid, A Rodgers, C Warlow, A Culpan, R Currie, S Flett, B Neal, A Milne, S Davis, et al.

Conference Proceedings | 1996 | Journal of Hypertension, Supplement

Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy. (Kopplung zwischen dem high-affinity IgE-Rezeptor-Gen und bronchialer Hyperreaktivität, auch in Abwesenheit von Atopie.)

L Van Herwerden, SB Harrap, ZYH Wong, MJ Abramson, JJ Kutin, AB Forbes, J Raven, A Lanigan, EH Walters, M Schürmann

Journal article | 1996 | Pneumologie

An appraisal of the genetic approaches to high blood pressure.

SB Harrap

Conference Proceedings | 1996 | Journal of Hypertension, Supplement

BACKGROUND: The genetics of high blood pressure is a growing field. Remarkable discoveries have been made in the rare genetic caus..

ACE inhibitors and arrhythmias

RWF Campbell

Journal article | 1996 | Heart

Cardiovascular disease and genetics of the renin-angiotensin system

SB Harrap

Journal article | 1996 | Heart

Cardiac transplantation, perindopril, and left ventricular hypertrophy in spontaneously hypertensive rats

SB Harrap, JB OSullivan

Journal article | 1996 | Hypertension

Low affinity nerve growth factor receptor gene co-segregates with decreased bodyweight and increased left ventricular weight in spontaneously hypertensive rats

MK Kapuscinski, K Nemoto, T Ueyama, F Charchar, H Kageyama, K Fukumachi, M Sekimoto, E Senba, T Tomita, I Tomita, SB Harrap

Conference Proceedings | 1996 | Clinical and Experimental Pharmacology and Physiology

Plasma angiotensin II, predisposition to hypertension, and left ventricular size in healthy young adults

SB Harrap, AF Dominiczak, R Fraser, AF Lever, JJ Morton, CJ Foy, GCM Watt

Journal article | 1996 | Circulation

Nerve growth factor gene and hypertension in spontaneously hypertensive rats

M Kapuscinski, F Charchar, B Innes, GA Mitchell, TL Norman, SB Harrap

Journal article | 1996 | Journal of Hypertension

The PROGRESS study: Rationale and design

B Neal, S MacMahon, MG Bousser, J Chalmers, J Cutler, G Donnan, L Hansson, S Harrap, L Lisheng, G Mancia, J Menard, T Omae, J Reid, A Rodgers, C Warlow

Journal article | 1995 | Journal of Hypertension

LINKAGE OF HIGH-AFFINITY IGE RECEPTOR GENE WITH BRONCHIAL HYPERREACTIVITY, EVEN IN ABSENCE OF ATOPY

L VANHERWERDEN, SB HARRAP, ZYH WONG, MJ ABRAMSON, JJ KUTIN, AB FORBES, J RAVEN, A LANIGAN, EH WALTERS

Journal article | 1995 | The Lancet

MEASUREMENTS OF ANGIOTENSIN PEPTIDES

CM FERRARIO, KB BROSNIHAN, M CHAPPELL

Journal article | 1995 | Hypertension

CONVERTING-ENZYME INHIBITION AND ITS WITHDRAWAL IN SPONTANEOUSLY HYPERTENSIVE RATS

DJ CAMPBELL, AM DUNCAN, A KLADIS, SB HARRAP

Journal article | 1995 | Journal of Cardiovascular Pharmacology

INCREASED LEVELS OF BRADYKININ AND ITS METABOLITES IN TISSUES OF YOUNG SPONTANEOUSLY HYPERTENSIVE RATS

DJ CAMPBELL, AM DUNCAN, A KLADIS, SB HARRAP

Journal article | 1995 | Journal of Hypertension

THE S-A GENE - PREDISPOSITION TO HYPERTENSION AND RENAL-FUNCTION IN MAN

SB HARRAP, NJ SAMANI, D LODWICK, JM CONNOR, R FRASER, DL DAVIES, AF LEVER, CJW FOY, GCM WATT

Journal article | 1995 | Clinical Science

RENAL MEDULLA AND BRADYKININ DURING THE DEVELOPMENT OF HYPERTENSION IN SHR

JB OSULLIVAN, JF BERTRAM, SB HARRAP

Conference Proceedings | 1995 | Clinical and Experimental Pharmacology and Physiology

ANGIOTENSIN PEPTIDES IN SPONTANEOUSLY HYPERTENSIVE AND NORMOTENSIVE DONRYU RATS

DJ CAMPBELL, AM DUNCAN, A KLADIS, SB HARRAP

Journal article | 1995 | Hypertension

Repetitive gene mapping.

SB Harrap

Journal article | 1995 | Journal of Hypertension

RESETTING BLOOD-PRESSURE IN SPONTANEOUSLY HYPERTENSIVE RATS - THE ROLE OF BRADYKININ

JB OSULLIVAN, SB HARRAP

Journal article | 1995 | Hypertension

PUBLIC-HEALTH, CARDIOVASCULAR-DISEASE AND MOLECULAR-BIOLOGY

SB HARRAP

Conference Proceedings | 1994 | Kidney International

Genetics of coronary disease: beginning the long journey.

SB Harrap

Journal article | 1994 | The Lancet

DOES THE KIDNEY PLAY A ROLE IN THE SEXUAL DIMORPHISM OF BLOOD-PRESSURE IN SHR

GD GONG, WA PETTINGER

Journal article | 1994 | Hypertension

HYPERTENSION AND CARDIAC-HYPERTROPHY IN GROWTH HORMONE-DEFICIENT RATS

SB HARRAP, SR DATODI, EK CRAPPER, LA BACH

Journal article | 1994 | Clinical Science

HYPERTENSION - GENES VERSUS ENVIRONMENT

SB HARRAP

Journal article | 1994 | The Lancet

TRANSPLANTATION STUDIES OF THE ROLE OF THE KIDNEY IN LONG-TERM BLOOD-PRESSURE REDUCTION FOLLOWING BRIEF ACE-INHIBITOR TREATMENT IN YOUNG SPONTANEOUSLY HYPERTENSIVE RATS

SB HARRAP, BZ WANG, DG MACLELLAN

Conference Proceedings | 1994 | Clinical and Experimental Pharmacology and Physiology

BLOOD-PRESSURE AND LIFE-SPAN FOLLOWING BRIEF ACE-INHIBITOR TREATMENT IN YOUNG SPONTANEOUSLY HYPERTENSIVE RATS

SB HARRAP, C MIRAKIAN, SR DATODI, AF LEVER

Conference Proceedings | 1994 | Clinical and Experimental Pharmacology and Physiology

THE ANGIOTENSIN-I CONVERTING ENZYME GENE AND PREDISPOSITION TO HIGH BLOOD-PRESSURE

SB HARRAP, HR DAVIDSON, JM CONNOR, F SOUBRIER, P CORVOL, R FRASER, CJW FOY, GCM WATT

Journal article | 1993 | Hypertension

PULSE PRESSURE AND MICROVESSELS

SB HARRAP, AB FORBES

Journal article | 1993 | Hypertension

ANGIOTENSIN-II, SODIUM, AND CARDIOVASCULAR HYPERTROPHY IN SPONTANEOUSLY HYPERTENSIVE RATS

SB HARRAP, GA MITCHELL, DJ CASLEY, C MIRAKIAN, AE DOYLE

Journal article | 1993 | Hypertension

GENETICS AND THE RISK OF CORONARY HEART-DISEASE

SB HARRAP, GCM WATT

Journal article | 1992 | Medical Journal of Australia

DEVELOPMENT AND VALIDATION OF ECHOCARDIOGRAPHIC METHODS FOR ESTIMATING LEFT-VENTRICULAR MASS IN RATS

EF JONES, SB HARRAP, P CALAFIORE, AM TONKIN

Conference Proceedings | 1992 | Clinical and Experimental Pharmacology and Physiology

ABNORMALITIES OF GLUCOCORTICOID METABOLISM AND THE RENIN-ANGIOTENSIN SYSTEM - A 4-CORNERS APPROACH TO THE IDENTIFICATION OF GENETIC-DETERMINANTS OF BLOOD-PRESSURE

GCM WATT, SB HARRAP, CJW FOY, DW HOLTON, HV EDWARDS, HR DAVIDSON, JM CONNOR, AF LEVER, R FRASER

Journal article | 1992 | Journal of Hypertension

RENAL-TRANSPLANTATION BETWEEN MALE AND FEMALE SPONTANEOUSLY HYPERTENSIVE RATS

SB HARRAP, BZ WANG, DG MACLELLAN

Journal article | 1992 | Hypertension

ESSENTIAL-HYPERTENSION - A DISORDER OF GROWTH WITH ORIGINS IN CHILDHOOD

AF LEVER, SB HARRAP

Journal article | 1992 | Journal of Hypertension

A DEVELOPMENTAL GENETIC MECHANISM INVOLVING ANGIOTENSIN IN SPONTANEOUSLY HYPERTENSIVE RATS

SB HARRAP

Conference Proceedings | 1992 | Clinical and Experimental Pharmacology and Physiology

RENAL, CARDIOVASCULAR AND HORMONAL CHARACTERISTICS OF YOUNG-ADULTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY-DISEASE

SB HARRAP, DL DAVIES, AM MACNICOL, AF DOMINICZAK, R FRASER, AF WRIGHT, ML WATSON, JD BRIGGS

Journal article | 1991 | Kidney International

Angiotensin converting enzyme inhibitors, regional vascular hemodynamics, and the development and prevention of experimental genetic hypertension.

SB Harrap

Conference Proceedings | 1991 | American Journal of Hypertension

During the development of hypertension in young spontaneously hypertensive rats (SHR) vascular resistance is increased, particular..

Erratum: Assignment of the human angiotensin gene to chromosome 1q42-q43 by nonisotopic in situ hybridization, Volume 8, Number 3 (1990), pages 598-600

MN Isa, E Boyd, N Morrison, S Harrap, E Clauser, JM Connor

Journal article | 1991 | Genomics

BRIEF ANGIOTENSIN CONVERTING-ENZYME-INHIBITOR TREATMENT IN YOUNG SPONTANEOUSLY HYPERTENSIVE RATS REDUCES BLOOD-PRESSURE LONG-TERM

SB HARRAP, WM VANDERMERWE, SA GRIFFIN, F MACPHERSON, AF LEVER

Journal article | 1990 | Hypertension

ASSIGNMENT OF THE HUMAN ANGIOTENSIN GENE TO CHROMOSOME 1Q42-Q43 BY NONIOSOTOPIC INSITU HYBRIDIZATION

MN ISA, E BOYD, N MORRISON, S HARRAP, E CLAUSER, JM CONNOR

Journal article | 1990 | Genomics

REGIONAL CHROMOSOMAL ASSIGNMENT OF THE HUMAN MINERALOCORTICOID RECEPTOR GENE TO 4Q31.1

N MORRISON, SB HARRAP, JL ARRIZA, E BOYD, JM CONNOR

Journal article | 1990 | Human Genetics

REGIONAL CHROMOSOMAL ASSIGNMENT OF THE HUMAN GLUCOCORTICOID RECEPTOR GENE TO 5Q31

A THERIAULT, E BOYD, SB HARRAP, SM HOLLENBERG, JM CONNOR

Journal article | 1989 | Human Genetics

Failure of chronic administration of growth hormone to affect blood pressure, vascular reactivity and sodium metabolism in normal rats.

SB Harrap, F Macpherson, VG Wilson, DL Davies, OP Isaksson, B Folkow, AF Lever

Journal article | 1988 | Journal of Hypertension

To examine the effects of exogenous growth hormone on the cardiovascular system and sodium metabolism, ovine growth hormone was gi..

Effects of sodium intake and aldosterone on the renal pressure-natriuresis.

SB Harrap, SA Clark, R Fraser, A Towrie, AJ Brown, AF Lever

Journal article | 1988 | American Journal of Physiology-Renal Physiology

To study the effects of dietary sodium and plasma aldosterone on pressure-natriuresis (PN) we examined six groups of adult, male S..

GENETIC CO-SEGREGATION OF RENAL HEMODYNAMICS AND BLOOD-PRESSURE IN THE SPONTANEOUSLY HYPERTENSIVE RAT

SB HARRAP, AE DOYLE

Journal article | 1988 | Clinical Science

Causes and effects of high blood pressure: a longitudinal approach to genetic cosegregational analysis.

SB Harrap

Journal article | 1988 | Journal of Cardiovascular Pharmacology

Numerous biochemical and physiological phenotypic differences exist between genetically normotensive and hypertensive rats. Only s..

PERSISTENT EFFECTS ON BLOOD-PRESSURE AND RENAL HEMODYNAMICS FOLLOWING CHRONIC ANGIOTENSIN CONVERTING ENZYME-INHIBITION WITH PERINDOPRIL

SB HARRAP, JA NICOLACI, AE DOYLE

Journal article | 1986 | Clinical and Experimental Pharmacology and Physiology

Renal haemodynamics and total body sodium in immature spontaneously hypertensive and Wistar-Kyoto rats.

SB Harrap, AE Doyle

Journal article | 1986 | Journal of Hypertension

We have investigated the renal haemodynamics and sodium metabolism in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats..

GENETIC-ANALYSIS OF BLOOD-PRESSURE AND SODIUM-BALANCE IN SPONTANEOUSLY HYPERTENSIVE RATS

SB HARRAP

Journal article | 1986 | Hypertension

PRESSOR SENSITIVITY TO ANGIOTENSIN-I AND ANGIOTENSIN-II DURING THE DEVELOPMENT OF EXPERIMENTAL RENAL-HYPERTENSION IN THE RAT

AE DOYLE, SB HARRAP, J TORRESI

Journal article | 1986 | Clinical and Experimental Pharmacology and Physiology

TOTAL-BODY SODIUM IN IMMATURE SPONTANEOUSLY HYPERTENSIVE AND WISTAR KYOTO RATS

SB HARRAP, AE DOYLE

Journal article | 1985 | Clinical and Experimental Pharmacology and Physiology

Reply by authors

SB Harrap, WJ Louis, AE Doyle

Journal article | 1985 | Journal of Hypertension

Failure of psychosocial stress to induce chronic hypertension in the rat.

SB Harrap, WJ Louis, AE Doyle

Journal article | 1984 | Journal of Hypertension

The effect of psychosocial stress produced by aggregation in a special cage designed by Henry was investigated in three separate e..

Sodium intake and exchangeable sodium in hypertensive rats.

SJ Harrap, R DiNicolantonio, AE Doyle

Journal article | 1984 | Clinical and Experimental Hypertension. Part A: Theory and Practice

Exchangeable sodium, extracellular fluid volume and sodium intake were significantly higher in spontaneously hypertensive rats (SH..

ERYTHROCYTE CATION COTRANSPORT AND COUNTERTRANSPORT IN ESSENTIAL-HYPERTENSION

JS WILEY, DA CLARKE, LA BONACQUISTO, JD SCARLETT

Journal article | 1984 | Hypertension

340

Scholarly Works

Keyword Analysis

Clinical Health (organs, Diseases and Abnormal Conditions)

Cardiovascular Medicine and Haematology

Clinical Sciences

Clinical (organs, Diseases and Abnormal Conditions)

Genetics

Medical Physiology

Expanding Knowledge

Public Health and Health Services

Medical Biochemistry and Metabolomics

Other Medical and Health Sciences

Honours, Awards and Fellowships

1984

FRACP - Fellow of the Royal Australasian College of Physicians

1

Award

Credentials

Positions

Professor

Physiology

Chairman Of Board

Austin Hospital Medical Research Foundation

Member

Australian Physiological Society

President

High Blood Pressure Research Council of Australia

Trustee

High Blood Pressure Research Foundation

Fellow

American Heart Association

Secretary

International Society of Hypertension

Education

Doctor of Philosophy

University of Melbourne

Bachelor of Medicine & Bachelor of Surgery

University of Melbourne

Prof

Stephen Harrap

Professor

Prof

Stephen Harrap

Enquiries

Contact Stephen

Division

Medicine, Dentistry And Health Sciences

Primary Interest

Genetics of common conditions

Prof

Stephen Harrap

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Find out more about Stephen Harrap's experience

Stephen Harrap's highlights

FEATURED Journal article

Does glyceryl trinitrate cause central sympatholytic effects? Insights from a case of baroreflex failure

Stephen Harrap's selected work

Research Grant

Journal article

Research Grant

Journal article

Research Grant

Journal article

Projects

New Camkii Therapeutic Targets In Heart Failure With Preserved Ejection Fraction

Y Chromosome Mechanisms In Coronary Artery Disease

New Strategies For Preventing Hypertension

New Strategies For Preventing Hypertension

Local Cardiac Sex Steroids - New Therapeutic Targets

Local Cardiac Sex Steroids - New Therapeutic Targets

Excellence In Noncommunicable Disease Research (Encore) Between Australia And India

Animal Services Provided By Deakin University - Supply Of Services Agreement.

Novel Genetic Strategies For Heart Disease

New Genetic Approaches For Heart Disease

Linking Early Heart Growth Abnormality With Later Cardiac Disease Development.

Genes Of The Renin-Angiotensin System And Their Association With Blood Pressure And Cardiovascular Disease

Explaining Elevated Risk For Early Heart Disease In Psychosis

Understanding Enlargement Of The Heart

Genes Determining Postural Blood Pressure Responses

Identificatin Of Dna Variation On Chromosome 16p12 Responsible For The Control Of Blood Pressure

Melbourne Research Grant Support Scheme 2014 - Molecular Programming Of The Development And Prevention Of Hypertension

Finding The Genes Driving Alcohol Consumption - An Experimental Approach

Multiphoton Microscope - Neuroscience Core Facility

A Paradigm Of Genomic Discovery - An Investigation Of The Allelic Architecture Of Height

Linkage And Association Analyses Of A Locus On Chromosome 4 That Contributes To Population Variation In Hdl Cholesterol

Angiotensin Receptor Gene Polymorphism And Human Heart Size

22

Projects

Project Types

Scholarly Works

Does glyceryl trinitrate cause central sympatholytic effects? Insights from a case of baroreflex failure

The Risks of Cardiovascular Disease and Mortality Following Weight Change in Adults with Diabetes: Results from ADVANCE.

Change in Blood Pressure Variability Among Treated Elderly Hypertensive Patients and Its Association With Mortality.

The relationship between eGFR slope and subsequent risk of vascular outcomes and all-cause mortality in type 2 diabetes: the ADVANCE-ON study

Response of 1,5-anhydroglucitol level to intensive glucose- and blood-pressure lowering interventions, and its associations with clinical outcomes in the ADVANCE trial

Combination of Changes in Estimated GFR and Albuminuria and the Risk of Major Clinical Outcomes

Effects of Blood Pressure Lowering on Clinical Outcomes According to Baseline Blood Pressure and Cardiovascular Risk in Patients With Type 2 Diabetes Mellitus: The ADVANCE Trial

EPHA4 regulates vascular smoothmuscle cell contractility and is a sex-specific hypertension risk gene in individuals with type 2 diabetes

New Blood Pressure Guidelines Pose Difficult Choices for Australian Physicians

Genetics of obesity in consanguineous populations - A road map to provide novel insights in the molecular basis and management of obesity

Acute Increases in Serum Creatinine After Starting Angiotensin-Converting Enzyme Inhibitor-Based Therapy and Effects of its Continuation on Major Clinical Outcomes in Type 2 Diabetes Mellitus: The ADVANCE Trial

CIRCULAR RNAS HRCR AND CTTN ARE UPREGULATED IN THE HYPERTROPHIC HEART INDEPENDENT OF BLOOD PRESSURE

CIRCULAR RNA EXPRESSION IS RESET BY BRIEF ANTIHYPERTENSIVE TREATMENT IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR)

ANGIOTENSIN CONVERTING ENZYME INHIBITORS EPIGENETICALLY ATENUATE TELOMERE SHORTENING

Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy

Cardiac function in pregnancy

Use of the waist-to-height ratio to predict cardiovascular risk in patients with diabetes: Results from the ADVANCE-ON study

Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive-A New Preclinical Model

Pericardial adipose and aromatase: A new translational target for aging, obesity and arrhythmogenesis?

Cardiac Stress and Inflammatory Markers as Predictors of Heart Failure in Patients With Type 2 Diabetes: The ADVANCE Trial.

Prognostic Value of Variability in Systolic Blood Pressure Related to Vascular Events and Premature Death in Type 2 Diabetes Mellitus The ADVANCE-ON Study

Comparative effects of microvascular and macrovascular disease on the risk of major outcomes in patients with type 2 diabetes

Genetics of blood pressure: time to curate the collection

Side effects and tolerability of combination blood pressure lowering according to blood pressure levels: an analysis of the PROGRESS and ADVANCE trials

Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

Familial Analysis of Epistatic and Sex-Dependent Association of Genes of the Renin-Angiotensin-Aldosterone System and Blood Pressure

The impact of level of education on vascular events and mortality in patients with type 2 diabetes mellitus: Results from the ADVANCE study