Stephen Harrap

Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control (vol 64, pg 2012, 2021)

Johanne Tremblay, Mounsif Haloui, Redha Attaoua, Ramzan Tahir, Camil Hishmih, Francois Harvey, Francois-Christophe Marois-Blanchet, Carole Long, Paul Simon, Lara Santucci, Candan Hizel, John Chalmers, Michel Marre, Stephen Harrap, Renata Cifkova, Alena Krajcoviechova, David R Matthews, Bryan Williams, Neil Poulter, Sophia Zoungas, et al.

Journal article  |  2021  |  DIABETOLOGIA

The authors regret that they omitted to acknowledge the clinical and organisational assistance of M.-R. Guertin and P. Dumas (CRCH..

Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function.

June-Chiew Han, Kenneth Tran, David J Crossman, Claire L Curl, Parisa Koutsifeli, Joshua PH Neale, Xun Li, Stephen B Harrap, Andrew J Taberner, Lea MD Delbridge, Denis S Loiselle, Kimberley M Mellor

Journal article  |  2021  |  J Gen Physiol

Increased heart size is a major risk factor for heart failure and premature mortality. Although abnormal heart growth subsequent t..

Combination blood pressure lowering in the presence or absence of background statin and aspirin therapy: a combined analysis of PROGRESS and ADVANCE Trials

Nelson Wang, Katie Harris, John Chalmers, Stephen Harrap, Giuseppe Mancia, Michel Marre, Neil Poulter, Christophe Tzourio, Bryan Williams, Sophia Zoungas, Mark Woodward, Anthony Rodgers

Journal article  |  2021  |  JOURNAL OF HYPERTENSION

OBJECTIVES: To assess the effects of combination BP lowering on cardiovascular events and mortality in the presence of aspirin and..

Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control

Johanne Tremblay, Mounsif Haloui, Redha Attaoua, Ramzan Tahir, Camil Hishmih, Francois Harvey, Francois-Christophe Marois-Blanchet, Carole Long, Paul Simon, Lara Santucci, Candan Hizel, John Chalmers, Michel Marre, Stephen Harrap, Renata Cifkova, Alena Krajcoviechova, David R Matthews, Bryan Williams, Neil Poulter, Sophia Zoungas, et al.

Journal article  |  2021  |  DIABETOLOGIA

AIMS/HYPOTHESIS: Type 2 diabetes increases the risk of cardiovascular and renal complications, but early risk prediction could lea..

The Impact of Frailty on the Effectiveness and Safety of Intensive Glucose Control and Blood Pressure-Lowering Therapy for People With Type 2 Diabetes: Results From the ADVANCE Trial

Tu N Nguyen, Katie Harris, Mark Woodward, John Chalmers, Mark Cooper, Pavel Hamet, Stephen Harrap, Simon Heller, Stephen MacMahon, Giuseppe Mancia, Michel Marre, Neil Poulter, Anthony Rogers, Bryan Williams, Sophia Zoungas, Clara K Chow, Richard I Lindley

Journal article  |  2021  |  DIABETES CARE

OBJECTIVE: To develop a frailty index (FI) and explore the relationship of frailty to subsequent adverse outcomes on the effective..

Sex differences in risk factors for cognitive decline and dementia, including death as a competing risk, in individuals with diabetes: Results from the ADVANCE trial

Jessica Gong, Katie Harris, Maree Hackett, Sanne AE Peters, Henry Brodaty, Mark Cooper, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Stephen MacMahon, John Chalmers, Mark Woodward

Journal article  |  2021  |  DIABETES OBESITY & METABOLISM

AIM: To estimate the associations between risk factors and cognitive decline (CD)/dementia, and the sex differences in these risk ..

Variability in estimated glomerular filtration rate and the risk of major clinical outcomes in diabetes: Post hoc analysis from the ADVANCE trial

Min Jun, Katie Harris, Hiddo JL Heerspink, Sunil V Badve, Meg J Jardine, Stephen Harrap, Pavel Hamet, Michel Marre, Neil Poulter, Sradha Kotwal, Martin Gallagher, Vlado Perkovic, John Chalmers, Mark Woodward

Journal article  |  2021  |  DIABETES OBESITY & METABOLISM

There are limited data on whether estimated glomerular filtration rate (eGFR) variability modifies the risk of future clinical out..

The comparative effects of intensive glucose lowering in diabetes patients aged below or above 65 years: Results from the ADVANCE trial

Toshiaki Ohkuma, John Chalmers, Mark Cooper, Pavel Hamet, Stephen Harrap, Michel Marre, Giuseppe Mancia, Neil Poulter, Mark Woodward

Journal article  |  2021  |  DIABETES OBESITY & METABOLISM

AIMS: For relatively old patients with diabetes, current guidelines recommend adjustment of glycaemic goals based on patients' cog..

Comparison of Circulating Biomarkers in Predicting Diabetic Kidney Disease Progression With Autoantibodies to Erythropoietin Receptor

Megumi Oshima, Akinori Hara, Tadashi Toyama, Min Jun, Carol Pollock, Meg Jardine, Stephen Harrap, Neil Poulter, Mark E Cooper, Mark Woodward, John Chalmers, Vlado Perkovic, Muh Geot Wong, Takashi Wada

Journal article  |  2021  |  KIDNEY INTERNATIONAL REPORTS

Introduction: Several circulating markers, including autoantibodies to erythropoietin receptor (anti-EPOR antibodies), have been i..

History of lower-limb complications and risk of cancer death in people with type 2 diabetes

Kamel Mohammedi, Stephen Harrap, Giuseppe Mancia, Michel Marre, Neil Poulter, John Chalmers, Mark Woodward

Journal article  |  2021  |  CARDIOVASCULAR DIABETOLOGY

BACKGROUND: Individuals with diabetes and lower-limb complications are at high risk for cardiovascular and all-cause mortality, bu..