Stephen Harrap

Sex differences in risk factors for cognitive decline and dementia, including death as a competing risk, in individuals with diabetes: Results from the ADVANCE trial

Jessica Gong, Katie Harris, Maree Hackett, Sanne AE Peters, Henry Brodaty, Mark Cooper, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Stephen MacMahon, John Chalmers, Mark Woodward

Journal article  |  2021  |  Diabetes Obesity and Metabolism

AIM: To estimate the associations between risk factors and cognitive decline (CD)/dementia, and the sex differences in these risk ..

Combination blood pressure lowering in the presence or absence of background statin and aspirin therapy: a combined analysis of PROGRESS and ADVANCE Trials.

Nelson Wang, Katie Harris, John Chalmers, Stephen Harrap, Giuseppe Mancia, Michel Marre, Neil Poulter, Christophe Tzourio, Bryan Williams, Sophia Zoungas, Mark Woodward, Anthony Rodgers

Journal article  |  2021  |  Journal of Hypertension

OBJECTIVES: To assess the effects of combination BP lowering on cardiovascular events and mortality in the presence of aspirin and..

Variability in estimated glomerular filtration rate and the risk of major clinical outcomes in diabetes: Post hoc analysis from the ADVANCE trial

Min Jun, Katie Harris, Hiddo JL Heerspink, Sunil V Badve, Meg J Jardine, Stephen Harrap, Pavel Hamet, Michel Marre, Neil Poulter, Sradha Kotwal, Martin Gallagher, Vlado Perkovic, John Chalmers, Mark Woodward

Journal article  |  2021  |  Diabetes Obesity and Metabolism

There are limited data on whether estimated glomerular filtration rate (eGFR) variability modifies the risk of future clinical out..

The comparative effects of intensive glucose lowering in diabetes patients aged below or above 65 years: Results from the ADVANCE trial

Toshiaki Ohkuma, John Chalmers, Mark Cooper, Pavel Hamet, Stephen Harrap, Michel Marre, Giuseppe Mancia, Neil Poulter, Mark Woodward

Journal article  |  2021  |  Diabetes Obesity and Metabolism

AIMS: For relatively old patients with diabetes, current guidelines recommend adjustment of glycaemic goals based on patients' cog..

Comparison of Circulating Biomarkers in Predicting Diabetic Kidney Disease Progression With Autoantibodies to Erythropoietin Receptor

Megumi Oshima, Akinori Hara, Tadashi Toyama, Min Jun, Carol Pollock, Meg Jardine, Stephen Harrap, Neil Poulter, Mark E Cooper, Mark Woodward, John Chalmers, Vlado Perkovic, Muh Geot Wong, Takashi Wada

Journal article  |  2021  |  Kidney International Reports

Introduction: Several circulating markers, including autoantibodies to erythropoietin receptor (anti-EPOR antibodies), have been i..

History of lower-limb complications and risk of cancer death in people with type 2 diabetes

Kamel Mohammedi, Stephen Harrap, Giuseppe Mancia, Michel Marre, Neil Poulter, John Chalmers, Mark Woodward

Journal article  |  2021  |  Cardiovascular Diabetology

BACKGROUND: Individuals with diabetes and lower-limb complications are at high risk for cardiovascular and all-cause mortality, bu..

Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney

Xiao Jiang, James M Eales, David Scannali, Alicja Nazgiewicz, Priscilla Prestes, Michelle Maier, Matthew Denniff, Xiaoguang Xu, Sushant Saluja, Eddie Cano-Gamez, Wojciech Wystrychowski, Monika Szulinska, Andrzej Antczak, Sean Byars, Damian Skrypnik, Maciej Glyda, Robert Krol, Joanna Zywiec, Ewa Zukowska-Szczechowska, Louise M Burrell, et al.

Journal article  |  2020  |  European Heart Journal

AIMS: Angiotensin-converting enzyme 2 (ACE2) is the cellular entry point for severe acute respiratory syndrome coronavirus (SARS-C..

The assertive cardiac care trial: A randomised controlled trial of a coproduced assertive cardiac care intervention to reduce absolute cardiovascular disease risk in people with severe mental illness in the primary care setting

Matthew Lewis, Patty Chondros, Cathrine Mihalopoulos, Yong Yi Lee, Jane M Gunn, Carol Harvey, John Furler, David Osborn, David Castle, Sandra Davidson, Mahesh Jayaram, Amanda Kenny, Mark R Nelson, Vera A Morgan, Stephen Harrap, Kylie McKenzie, Maria Potiriadis, Konstancja Densley, Victoria J Palmer

Journal article  |  2020  |  Contemporary Clinical Trials

BACKGROUND: Cardiovascular disease (CVD) accounts for 40% of the excess mortality identified in people with severe mental illness ..

Alternative kidney filtration markers and the risk of major macrovascular and microvascular events, andall-causemortality in individuals with type 2 diabetes in theADVANCEtrial

Hyunju Kim, Dan Wang, John Chalmers, Min Jun, Sophia Zoungas, Michel Marre, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Neil R Poulter, Mark E Cooper, Mark Woodward, Elizabeth Selvin, Casey M Rebholz

Journal article  |  2020  |  Journal of Diabetes

BACKGROUND: Creatinine-based estimated glomerular filtration rate (eGFR) is biased in the setting of obesity and other conditions...

Sex-specific associations between cardiovascular risk factors and myocardial infarction in patients with type 2 diabetes: TheADVANCE-ONstudy

Toshiaki Ohkuma, Sanne AE Peters, Min Jun, Stephen Harrap, Mark Cooper, Pavel Hamet, Neil Poulter, John Chalmers, Mark Woodward

Journal article  |  2020  |  Diabetes Obesity and Metabolism

AIM: To examine possible sex differences in the excess risk of myocardial infarction (MI) consequent to a range of conventional ri..